                         SEQUENCE LISTING

<110>  Autolus Limited
 
<120>  MOLECULE

<130>  P121993PCT1

<150>  GB2101491.5
<151>  2021-02-03

<160>  163   

<170>  PatentIn version 3.5

<210>  1
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human Fas

<400>  1

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  2
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fas extracellular domain

<400>  2

Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys Thr Val 
1               5                   10                  15      


Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp Gly Gln 
            20                  25                  30          


Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg Asp Cys 
        35                  40                  45              


Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu Gly Lys 
    50                  55                  60                  


Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg Cys Arg 
65                  70                  75                  80  


Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg 
                85                  90                  95      


Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys Asn Ser 
            100                 105                 110         


Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His Gly Ile 
        115                 120                 125             


Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu Glu Gly 
    130                 135                 140                 


Ser Arg Ser Asn 
145             


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fas TM domain

<400>  3

Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp 
1               5                   10                  15      


Val 
    


<210>  4
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fas cytoplasmic domain

<400>  4

Lys Arg Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn 
1               5                   10                  15      


Gln Gly Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile 
            20                  25                  30          


Asn Leu Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly 
        35                  40                  45              


Val Met Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val 
    50                  55                  60                  


Asn Glu Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr 
65                  70                  75                  80  


Ala Glu Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly 
                85                  90                  95      


Lys Lys Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn 
            100                 105                 110         


Leu Cys Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile 
        115                 120                 125             


Thr Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
    130                 135                 140                 


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain from anti-Fas antibody

<400>  5

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ile Cys Ala Val Tyr Gly Gly Ser Phe Ser Thr Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Thr Thr Asn Tyr Ser Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Ile Ser Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Leu Trp Ile Gly Glu Gly Asp Tyr Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain from anti-Fas antibody

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  7
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human FasL

<400>  7

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  8
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FasL extracellular domain

<400>  8

Ala Leu Val Gly Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln 
1               5                   10                  15      


Lys Glu Leu Ala Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala 
            20                  25                  30          


Ser Ser Leu Glu Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys 
        35                  40                  45              


Lys Glu Leu Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg 
    50                  55                  60                  


Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser 
65                  70                  75                  80  


Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu 
                85                  90                  95      


Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn 
            100                 105                 110         


Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln 
        115                 120                 125             


Asp Leu Val Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly 
    130                 135                 140                 


Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr 
145                 150                 155                 160 


Ser Ala Asp His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn 
                165                 170                 175     


Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
            180                 185                 


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention signal

<400>  9

Lys Asp Glu Leu 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention signal


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Lys Lys Xaa Xaa 
1               


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention signal


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Lys Xaa Lys Xaa Xaa 
1               5   


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention signal


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Arg Xaa Arg Arg 
1               


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Golgi retention signal

<400>  13

Ser Glu Lys Asp Glu Leu 
1               5       


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tail of adenoviral E19 protein

<400>  14

Lys Tyr Lys Ser Arg Arg Ser Phe Ile Asp Glu Lys Lys Met Pro 
1               5                   10                  15  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of HLA invariant chain

<400>  15

Met His Arg Arg Arg Ser Arg Ser Cys Arg 
1               5                   10  


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Golgi retention signal


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D or E

<400>  16

Lys Xaa Xaa 
1           


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Golgi retention signal

<400>  17

Tyr Gln Arg Leu 
1               


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  18

Asp Pro Ala Glu Pro Ser Glu Lys Asp Glu Leu 
1               5                   10      


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tail of adenoviral E19 protein

<400>  19

Asp Glu Lys Lys Met Pro 
1               5       


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  di-leucine signal

<400>  20

Asn Gln Pro Leu Leu Thr Asp 
1               5           


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  21

Gly Gly Gly Gly Ser 
1               5   


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGSGGGGS

<400>  22

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SGGGSGGGSGGGS

<400>  23

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa leader sequence

<400>  24

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  25
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-Fas-KDEL

<400>  25

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Arg Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys 
    50                  55                  60                  


Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Ile Cys Ala Val Tyr Gly Gly Ser Phe Ser Thr Tyr Tyr 
                165                 170                 175     


Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asn His Arg Gly Thr Thr Asn Tyr Ser Pro Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Ile Ser Leu Asn 
    210                 215                 220                 


Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Leu Leu Trp Ile Gly Glu Gly Asp Tyr Gly Leu Asp Val Trp Gly 
                245                 250                 255     


Gln Gly Thr Thr Val Thr Val Ser Ser Asp Pro Ala Glu Pro Ser Glu 
            260                 265                 270         


Lys Asp Glu Leu 
        275     


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A cleavage site

<400>  26

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rentention domain


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Asn Pro Xaa Tyr 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  retention domain


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an amino acid with a bulky hydrophobic side chain

<400>  28

Tyr Xaa Xaa Xaa 
1               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  retention domain


<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Asp Glu Xaa Xaa Xaa Leu Leu Ile 
1               5               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DX'X'LL

<400>  30

Asp Pro Phe Trp 
1               


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  retention signal


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is an amino acid with a bulky hydrophobic side chain

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an amino acid with a bulky hydrophobic side chain

<400>  31

Leu Xaa Xaa Xaa Asp Glu 
1               5       


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LLDLL

<400>  32

Leu Leu Asp Leu Leu 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PWDLW

<400>  33

Pro Trp Asp Leu Trp 
1               5   


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  retention signal

<400>  34

His Asp Glu Leu 
1               


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  retention signal


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Asp Xaa Xaa Leu Leu 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  retention signal


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Phe Xaa Asp Xaa Phe 
1               5   


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  37

Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  38

Val Glu Ile Gly Asn Pro Thr Tyr Lys Met Tyr Glu 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  39

Thr Asn Phe Thr Asn Pro Val Tyr Ala Thr Leu Tyr 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  40

Gly Asn Phe Ala Asn Pro Val Tyr Glu Ser Met Tyr 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  41

Thr Thr Phe Thr Asn Pro Val Tyr Glu Leu Glu Asp 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  42

Leu Arg Val Asp Asn Pro Leu Tyr Asp Pro Asp Ser 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  43

Ile Ile Phe Glu Asn Pro Met Tyr Ser Ala Arg Asp 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  44

Thr Asn Phe Glu Asn Pro Ile Tyr Ala Gln Met Glu 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  45

Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val 
1               5                   10          


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  46

Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
1               5                   10      


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  47

Trp Asp Thr Glu Asn Pro Ile Tyr Lys Gln Ala Thr 
1               5                   10          


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  48

Ser Thr Phe Lys Asn Pro Met Tyr Ala Gly Lys 
1               5                   10      


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  49

His Gly Tyr Glu Asn Pro Thr Tyr Arg Phe Leu Glu 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  50

Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  51

Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Tyr Phe Glu 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  52

Tyr Ala Ser Ser Asn Pro Glu Tyr Leu Ser Ala Ser 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  53

Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  54

Thr Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of NPXY signal

<400>  55

Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe 
1               5                   10          


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  56

Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 
1               5                   10      


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  57

Lys His His His Ala Gly Tyr Glu Gln Phe 
1               5                   10  


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  58

Lys Lys His His Asn Thr Gly Tyr Glu Gln Phe 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  59

Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  60

Arg Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
1               5                   10      


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  61

Arg Arg Arg Ser Thr Ser Arg Gly Tyr Met Ser Phe 
1               5                   10          


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  62

Arg Lys Arg Ser Arg Arg Gly Tyr Glu Ser Val 
1               5                   10      


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  63

Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
1               5                   10  


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  64

His Cys Gly Gly Pro Arg Pro Gly Tyr Glu Thr Leu 
1               5                   10          


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  65

His Cys Arg Thr Arg Arg Ala Glu Tyr Glu Thr Leu 
1               5                   10          


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  66

Arg Arg Arg Pro Ser Ala Tyr Gln Ala Leu 
1               5                   10  


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  67

Arg Arg Arg Ser Tyr Gln Asn Ile Pro 
1               5                   


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  68

Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  69

Arg Arg Arg Ser Ala Tyr Gln Asp Ile Arg 
1               5                   10  


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  70

Arg Lys Arg Arg Arg Ser Tyr Gln Asp Ile Met 
1               5                   10      


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  71

Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr His Thr Leu 
1               5                   10              


<210>  72
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  72

Lys Phe Tyr Lys Ala Arg Asn Glu Arg Asn Tyr His Thr Leu 
1               5                   10                  


<210>  73
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  73

Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
1               5                   10                  


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  74

Lys Ile Arg Gln Arg His Gln Ser Ser Ala Tyr Gln Arg Ile 
1               5                   10                  


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  75

His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Tyr Asp Gln Leu Asn 
1               5                   10                  15  


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  76

Ser Leu Ser Arg Gly Ser Gly Tyr Lys Glu Ile 
1               5                   10      


<210>  77
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  77

Arg Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr 
1               5                   10              


<210>  78
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  78

Arg Arg Ala Gly His Ser Ser Tyr Thr Pro Leu Pro Gly Ser 
1               5                   10                  


<210>  79
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  79

Lys Lys Leu Arg Gln Gln Lys Gln Gln Gly Tyr Gln Ala Ile Ile Asn 
1               5                   10                  15      


Asn Glu 
        


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  80

Arg Ser Lys Ser Asn Gln Asn Gln Ser Tyr Asn Leu Ile Gln Leu 
1               5                   10                  15  


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  81

Arg Lys Thr Phe Tyr Asn Asn Asn Gln Tyr Asn Gly Tyr Asn Ile Ile 
1               5                   10                  15      


Asn 
    


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  82

Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala 
1               5                   10  


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  83

Met Thr Lys Glu Tyr Gln Asp Leu Gln His Leu 
1               5                   10      


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  84

Ser Tyr Lys Tyr Ser Lys Val Asn Lys Glu 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  85

Pro Ala Ala Tyr Arg Gly Val Gly Asp Asp 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  86

Thr Gly Val Tyr Val Lys Met Pro Pro Thr 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  87

Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu 
1               5                   10  


<210>  88
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  88

Ala Ser Asp Tyr Gln Arg Leu Asn Leu Lys Leu 
1               5                   10      


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  89

Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
1               5                   10      


<210>  90
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of YXXZ-type signal

<400>  90

Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His Val Ala Asp Gly Glu 
1               5                   10                  15      


Asp His Ala 
            


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dileucine-based sorting signal


<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  91

Asp Glu Xaa Xaa Xaa Leu Leu Leu Ile 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  92

Ser Asp Lys Gln Thr Leu Leu Pro Asn 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  93

Asp Glu Arg Ala Pro Leu Ile Arg Thr 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  94

Gln Glu Lys Asp Pro Leu Leu Lys Asn 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  95

Thr Glu Arg Asn Pro Leu Leu Lys Ser 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  96

Gly Glu Asn Ser Pro Leu Leu Ser Gly 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  97

Glu Glu Lys Gln Pro Leu Leu Met Glu 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  98

Gly Glu Arg Gln Pro Leu Leu Gln Ser 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  99

Pro Glu Ile Gln Pro Leu Leu Thr Glu 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  100

Glu Gly Arg Gln Pro Leu Leu Gly Asp 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  101

Glu Ala Asn Gln Pro Leu Leu Thr Asp 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  102

Glu Leu His Gln Pro Leu Leu Thr Asp 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  103

Arg Glu Phe Glu Pro Leu Leu Asn Ala 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  104

Glu Glu Lys Met Ala Ile Leu Met Asp 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  105

Glu Glu Lys Leu Ala Ile Leu Ser Gln 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  106

Ser Glu Arg Asp Val Leu Leu Asp Glu 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  107

Ser Glu Arg Arg Asn Leu Leu Glu Asp 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  108

Asp Asp Ser Gly Asp Leu Leu Pro Gly 
1               5                   


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  109

Ser Gln Ile Lys Arg Leu Leu Ser Glu 
1               5                   


<210>  110
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  110

Ser His Ile Lys Arg Leu Leu Ser Glu 
1               5                   


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  111

Arg Arg Thr Pro Ser Leu Leu Glu Gln 
1               5                   


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  112

His Arg Thr Pro Ser Leu Leu Glu Gln 
1               5                   


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  113

Glu Pro Arg Gly Ser Arg Leu Leu Val Arg 
1               5                   10  


<210>  114
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  114

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Leu Gly Arg 
            


<210>  115
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  115

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                  15      


Leu Gly Asn 
            


<210>  116
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  116

Met Ala Glu Glu Gln Arg Asp Leu Ile Ser Ser Asp Gly Ser Ser Gly 
1               5                   10                  15      


Val Leu Pro Ile 
            20  


<210>  117
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  117

Met Glu Pro Asp His Gln Asn Glu Ser Leu Ile Gln Arg Val Pro Ser 
1               5                   10                  15      


Ala Glu Thr Ile Leu Gly Arg 
            20              


<210>  118
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  118

Met Ser Ser Glu Gly Asn Glu Thr Pro Leu Ile Ser Asp Gln Ser Ser 
1               5                   10                  15      


Val Asn Met Gly Pro Gln Pro 
            20              


<210>  119
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  119

Arg Pro Arg Arg Arg Thr Glu Glu Asp Glu Leu Leu Pro Glu Glu Ala 
1               5                   10                  15      


Glu Gly Leu Ile Asp Pro Gln Asn 
            20                  


<210>  120
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  120

Pro Asp Lys His Ser Leu Leu Val Gly Asp Phe Arg Glu Asp Asp Asp 
1               5                   10                  15      


Thr Ala Leu 
            


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  121

Thr Glu Arg Glu Arg Leu Leu Asn Phe 
1               5                   


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  122

Val Glu Thr Asp Asp Leu Ile Leu 
1               5               


<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  123

Phe Glu Asn Asp Ser Leu Leu 
1               5           


<210>  124
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  124

Asn Glu Gln Ser Pro Leu Leu His Asn 
1               5                   


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  125

Ser Glu Gln Thr Arg Leu Val Pro 
1               5               


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DEXXXLLLI sorting signal

<400>  126

Glu Val Asp Leu Asp Leu Leu Lys 
1               5               


<210>  127
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  127

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu His Ile 
1               5                   10              


<210>  128
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  128

Thr Phe His Asp Asp Ser Asp Glu Asp Leu Leu His Val 
1               5                   10              


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  129

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu Asn Ile 
1               5                   10              


<210>  130
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  130

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu Asn Val 
1               5                   10              


<210>  131
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  131

Glu Glu Ser Glu Glu Arg Asp Asp His Leu Leu Pro Met 
1               5                   10              


<210>  132
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  132

Asp Glu Ser Glu Glu Arg Asp Asp His Leu Leu Pro Met 
1               5                   10              


<210>  133
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  133

Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
1               5                   10          


<210>  134
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  134

Ile Thr Gly Phe Ser Asp Asp Val Pro Met Val Ile Ala 
1               5                   10              


<210>  135
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  135

Ile Asn Arg Phe Ser Asp Asp Glu Pro Leu Val Val Ala 
1               5                   10              


<210>  136
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  136

Met Leu Glu Ala Ser Asp Asp Glu Ala Leu Leu Val Cys 
1               5                   10              


<210>  137
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  137

Lys Asn Glu Thr Ser Asp Asp Glu Ala Leu Leu Leu Cys 
1               5                   10              


<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  138

Trp Val Val Glu Ala Glu Asp Glu Pro Leu Leu Ala 
1               5                   10          


<210>  139
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  139

Trp Val Ala Glu Ala Glu Asp Glu Pro Leu Leu Thr 
1               5                   10          


<210>  140
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  140

His Asp Asp Phe Ala Asp Asp Ile Ser Leu Leu Lys 
1               5                   10          


<210>  141
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  141

Gly Arg Asp Ser Pro Glu Asp His Ser Leu Leu Val Asn 
1               5                   10              


<210>  142
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  142

Val Arg Cys His Pro Glu Asp Asp Arg Leu Leu Gly 
1               5                   10          


<210>  143
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  143

His Arg Val Ser Gln Asp Asp Leu Asp Leu Leu Thr Ser 
1               5                   10              


<210>  144
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  144

Ala Ser Val Ser Leu Leu Asp Asp Glu Leu Met Ser Leu 
1               5                   10              


<210>  145
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  145

Ala Ser Ser Gly Leu Asp Asp Leu Asp Leu Leu Gly Lys 
1               5                   10              


<210>  146
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  146

Val Gln Asn Pro Ser Ala Asp Arg Asn Leu Leu Asp Leu 
1               5                   10              


<210>  147
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  147

Asn Ala Leu Ser Trp Leu Asp Glu Glu Leu Leu Cys Leu 
1               5                   10              


<210>  148
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of DXXLL sorting signal

<400>  148

Thr Val Asp Ser Ile Asp Asp Val Pro Leu Leu Ser Asp 
1               5                   10              


<210>  149
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  149

Gln Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly 
1               5                   10              


<210>  150
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  150

Arg Asp Arg Asp Tyr Asp Glu Asp Asp Glu Asp Asp Ile 
1               5                   10              


<210>  151
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  151

Leu Asp Glu Thr Glu Asp Asp Glu Leu Glu Tyr Asp Asp Glu Ser 
1               5                   10                  15  


<210>  152
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  152

Lys Asp Pro Asp Glu Val Glu Thr Glu Ser 
1               5                   10  


<210>  153
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  153

His Glu Phe Gln Asp Glu Thr Asp Thr Glu Glu Glu Thr 
1               5                   10              


<210>  154
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  154

Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr 
1               5                   10                  


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  155

Gly Glu Asp Glu Glu Ser Glu Ser Asp 
1               5                   


<210>  156
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  156

Gly Glu Asp Ser Asp Glu Glu Pro Asp His Glu Glu 
1               5                   10          


<210>  157
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  157

Phe Glu Asp Ser Glu Ser Thr Asp Thr Glu Glu Glu Phe 
1               5                   10              


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  158

Leu Glu Ala Gln Glu Glu Glu Glu Val 
1               5                   


<210>  159
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  159

Ala Asp Asp Leu Glu Ser Gly Leu Gly Ala Glu Asp Asp Leu Glu Gln 
1               5                   10                  15      


Asp Glu Gln Leu Glu Gly 
            20          


<210>  160
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  160

Thr Glu Ile Asp Glu Ser Phe Glu Met Thr Asp Phe 
1               5                   10          


<210>  161
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  161

Thr Glu Pro Glu Glu Val Glu Asp Phe Asp Phe Asp Leu Ser Asp Glu 
1               5                   10                  15      


Asp His 
        


<210>  162
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic cluster sorting signal

<400>  162

Phe Glu Ile Glu Glu Asp Asp Val Pro Thr Leu Glu Glu Glu His 
1               5                   10                  15  


<210>  163
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  163

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Arg Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys 
    50                  55                  60                  


Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Ile Cys Ala Val Tyr Gly Gly Ser Phe Ser Thr Tyr Tyr 
                165                 170                 175     


Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asn His Arg Gly Thr Thr Asn Tyr Ser Pro Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Ile Ser Leu Asn 
    210                 215                 220                 


Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Leu Leu Trp Ile Gly Glu Gly Asp Tyr Gly Leu Asp Val Trp Gly 
                245                 250                 255     


Gln Gly Thr Thr Val Thr Val Ser Ser Asp Pro Ala Glu Pro Ser Glu 
            260                 265                 270         


Lys Asp Glu Leu Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
        275                 280                 285             


Glu Glu Asn Pro Gly Pro Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro 
    290                 295                 300                 


Gln Ile Tyr Trp Val Asp Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro 
305                 310                 315                 320 


Gly Thr Val Leu Pro Cys Pro Thr Ser Val Pro Arg Arg Pro Gly Gln 
                325                 330                 335     


Arg Arg Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro 
            340                 345                 350         


Pro Pro Pro Pro Leu Pro Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg 
        355                 360                 365             


Gly Asn His Ser Thr Gly Leu Cys Leu Leu Val Met Phe Phe Met Val 
    370                 375                 380                 


Leu Val Ala Leu Val Gly Leu Gly Leu Gly Met Phe Gln Leu Phe His 
385                 390                 395                 400 


Leu Gln Lys Glu Leu Ala Glu Leu Arg Glu Ser Thr Ser Gln Met His 
                405                 410                 415     


Thr Ala Ser Ser Leu Glu Lys Gln Ile Gly His Pro Ser Pro Pro Pro 
            420                 425                 430         


Glu Lys Lys Glu Leu Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn 
        435                 440                 445             


Ser Arg Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu 
    450                 455                 460                 


Leu Ser Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr 
465                 470                 475                 480 


Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys 
                485                 490                 495     


Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr 
            500                 505                 510         


Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr 
        515                 520                 525             


Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn 
    530                 535                 540                 


Leu Thr Ser Ala Asp His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu 
545                 550                 555                 560 


Val Asn Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
                565                 570                 575 


