                         б
<110>  ϺƼɷ޹˾
<120>  LAG-3Ŀ弰;
<130>  
<150>  CN202110171586.8  
<151>  2021-02-08
<160>  90   
<170>  PatentIn汾3.3
<210>  1
<211>  124
<212>  PRT
<213>  ˹
<220>
<223>  7C5 VH
<400>  1
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Tyr Pro Arg Ser Asp Asn Thr Tyr Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys 
                85                  90                  95      
Ala Arg Arg Ala Phe Tyr Tyr Tyr Gly Ser Asn Tyr Tyr Ala Met Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 
<210>  2
<211>  112
<212>  PRT
<213>  ˹
<220>
<223>  7C5 VL
<400>  2
Asp Val Leu Met Thr Gln Thr Pro Leu Phe Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Arg Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Phe Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
<210>  3
<211>  118
<212>  PRT
<213>  ˹
<220>
<223>  4C8 VH
<400>  3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ile Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Thr Tyr Gly Thr Thr Tyr Thr Phe Tyr Ser Asp Asn Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Ser 
65                  70                  75                  80  
Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Glu Tyr Gly Ser Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala 
        115             
<210>  4
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  4C8 VL
<400>  4
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              
Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         
<210>  5
<211>  115
<212>  PRT
<213>  ˹
<220>
<223>  7F1 VH
<400>  5
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          
Ala Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Val Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  
Ser Arg Leu Ile Ile Thr Arg Asp Asn Ser Lys Arg Gln Val Phe Leu 
65                  70                  75                  80  
Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Lys Gly Gly Gly Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 
<210>  6
<211>  108
<212>  PRT
<213>  ˹
<220>
<223>  7F1 VL
<400>  6
Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Val Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln His Tyr Asn Thr Asn Pro Pro Thr 
                85                  90                  95      
Trp Thr Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys 
            100                 105             
<210>  7
<211>  121
<212>  PRT
<213>  ˹
<220>
<223>  7F10 VH
<400>  7
Glu Val Lys Leu Met Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Val Ser Gly Val Asn Ile Lys Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ser Asp Thr Ser Ser Asn Thr Gly Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Phe Tyr Ser Asn Tyr Val Asn Tyr Phe Asp Gln Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     
<210>  8
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  7F10 VL
<400>  8
Asp Ile Val Met Thr Gln Ala Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      
Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          
Val Ser Trp Phe Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         
<210>  9
<211>  112
<212>  PRT
<213>  ˹
<220>
<223>  3A10 VH
<400>  9
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          
Tyr Met His Trp Met Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Asp Pro Glu Asn Gly Glu Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Tyr Ser Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Phe Ser Ser Leu Thr Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Phe Asp Tyr Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 
            100                 105                 110         
<210>  10
<211>  112
<212>  PRT
<213>  ˹
<220>
<223>  3A10 VL
<400>  10
Asp Ile Val Met Thr Gln Ala Pro Val Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Phe Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
<210>  11
<211>  124
<212>  PRT
<213>  ˹
<220>
<223>  10B4 VH
<400>  11
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Gly Ile Ser Trp Met Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Tyr Pro Arg Gly Gly Asn Thr Tyr Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Gln Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Arg Ala Phe Tyr Tyr Phe Gly Ser Asn Tyr Tyr Ala Met Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 
<210>  12
<211>  112
<212>  PRT
<213>  ˹
<220>
<223>  10B4 VL
<400>  12
Asp Val Val Met Thr Gln Thr Pro Leu Phe Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Ala Ile Lys 
            100                 105                 110         
<210>  13
<211>  447
<212>  PRT
<213>  ˹
<220>
<223>  BMS-986016 
<400>  13
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Tyr 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Arg Gly Ser Thr Asn Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Phe Gly Tyr Ser Asp Tyr Glu Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         
<210>  14
<211>  214
<212>  PRT
<213>  ˹
<220>
<223>  BMS-986016 
<400>  14
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 
<210>  15
<211>  121
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VH1
<400>  15
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asp Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Phe Tyr Ser Asn Tyr Val Asn Tyr Phe Asp Gln Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     
<210>  16
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VL1
<400>  16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         
<210>  17
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VL2
<400>  17
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         
<210>  18
<211>  121
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VH2
<400>  18
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Phe Tyr Ser Asn Tyr Val Asn Tyr Phe Asp Gln Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     
<210>  19
<211>  121
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VH3
<400>  19
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asp Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Phe Tyr Ser Asn Tyr Val Asn Tyr Phe Asp Gln Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     
<210>  20
<211>  121
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VH4
<400>  20
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Phe Tyr Ser Asn Tyr Val Asn Tyr Phe Asp Gln Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     
<210>  21
<211>  121
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VH5
<400>  21
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Lys Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asp Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Phe Tyr Ser Asn Tyr Val Asn Tyr Phe Asp Gln Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     
<210>  22
<211>  121
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VH6
<400>  22
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Asn Phe Thr Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asp Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Phe Tyr Ser Asn Tyr Val Asn Tyr Phe Asp Gln Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     
<210>  23
<211>  121
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VH7
<400>  23
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Asn Ile Lys Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Phe Tyr Ser Asn Tyr Val Asn Tyr Phe Asp Gln Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     
<210>  24
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VL3
<400>  24
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          
Val Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         
<210>  25
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VL4
<400>  25
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         
<210>  26
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VL5
<400>  26
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         
<210>  27
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VL6
<400>  27
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         
<210>  28
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  hz7F10_VL7
<400>  28
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          
Val Ser Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         
<210>  29
<211>  327
<212>  PRT
<213>  ˹
<220>
<223>  㶨
<400>  29
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         
<210>  30
<211>  107
<212>  PRT
<213>  ˹
<220>
<223>  㶨
<400>  30
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         
<210>  31
<211>  5
<212>  PRT
<213>  ˹
<220>
<223>  7C5 HCDR1
<400>  31
Ser Tyr Gly Ile Ser 
1               5   
<210>  32
<211>  17
<212>  PRT
<213>  ˹
<220>
<223>  7C5 HCDR2
<400>  32
Glu Ile Tyr Pro Arg Ser Asp Asn Thr Tyr Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      
Gly 
    
<210>  33
<211>  15
<212>  PRT
<213>  ˹
<220>
<223>  7C5 HCDR3
<400>  33
Arg Ala Phe Tyr Tyr Tyr Gly Ser Asn Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15  
<210>  34
<211>  16
<212>  PRT
<213>  ˹
<220>
<223>  7C5 LCDR110B4 LCDR1
<400>  34
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asp Thr Tyr Leu Glu 
1               5                   10                  15      
<210>  35
<211>  7
<212>  PRT
<213>  ˹
<220>
<223>  7C5 LCDR210B4 LCDR2
<400>  35
Lys Val Ser Asn Arg Phe Ser 
1               5           
<210>  36
<211>  9
<212>  PRT
<213>  ˹
<220>
<223>  7C5 LCDR310B4 LCDR3
<400>  36
Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   
<210>  37
<211>  5
<212>  PRT
<213>  ˹
<220>
<223>  4C8 HCDR1
<400>  37
Asn Tyr Ala Met Ser 
1               5   
<210>  38
<211>  17
<212>  PRT
<213>  ˹
<220>
<223>  4C8 HCDR2
<400>  38
Thr Ile Thr Tyr Gly Thr Thr Tyr Thr Phe Tyr Ser Asp Asn Val Lys 
1               5                   10                  15      
Gly 
    
<210>  39
<211>  9
<212>  PRT
<213>  ˹
<220>
<223>  4C8 HCDR3
<400>  39
Gly Glu Tyr Gly Ser Ser Phe Ala Tyr 
1               5                   
<210>  40
<211>  11
<212>  PRT
<213>  ˹
<220>
<223>  4C8 LCDR1
<400>  40
Lys Ala Ser Gln Asn Val Arg Thr Ala Val Ala 
1               5                   10      
<210>  41
<211>  7
<212>  PRT
<213>  ˹
<220>
<223>  4C8 LCDR2
<400>  41
Leu Ala Ser Asn Arg His Thr 
1               5           
<210>  42
<211>  9
<212>  PRT
<213>  ˹
<220>
<223>  4C8 LCDR3
<400>  42
Leu Gln His Trp Asn Tyr Pro Leu Thr 
1               5                   
<210>  43
<211>  5
<212>  PRT
<213>  ˹
<220>
<223>  7F1 HCDR1
<400>  43
Asp Tyr Ala Val Ser 
1               5   
<210>  44
<211>  16
<212>  PRT
<213>  ˹
<220>
<223>  7F1 HCDR2
<400>  44
Val Val Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser 
1               5                   10                  15      
<210>  45
<211>  7
<212>  PRT
<213>  ˹
<220>
<223>  7F1 HCDR3
<400>  45
Gly Gly Gly Gly Met Asp Tyr 
1               5           
<210>  46
<211>  10
<212>  PRT
<213>  ˹
<220>
<223>  7F1 LCDR1
<400>  46
Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  
<210>  47
<211>  7
<212>  PRT
<213>  ˹
<220>
<223>  7F1 LCDR2
<400>  47
Ala Thr Ser Asn Leu Ala Ser 
1               5           
<210>  48
<211>  11
<212>  PRT
<213>  ˹
<220>
<223>  7F1 LCDR3
<400>  48
Gln His Tyr Asn Thr Asn Pro Pro Thr Trp Thr 
1               5                   10      
<210>  49
<211>  5
<212>  PRT
<213>  ˹
<220>
<223>  7F10 HCDR13A10 HCDR1Դhz7F10 HCDR1
<400>  49
Asp Asp Tyr Met His 
1               5   
<210>  50
<211>  17
<212>  PRT
<213>  ˹
<220>
<223>  7F10 HCDR2Դhz7F10 HCDR2
<400>  50
Arg Ile Asp Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      
Gly 
    
<210>  51
<211>  12
<212>  PRT
<213>  ˹
<220>
<223>  7F10 HCDR3Դhz7F10 HCDR3
<400>  51
Ser Phe Tyr Ser Asn Tyr Val Asn Tyr Phe Asp Gln 
1               5                   10          
<210>  52
<211>  11
<212>  PRT
<213>  ˹
<220>
<223>  7F10 LCDR1Դhz7F10 LCDR1
<400>  52
Lys Ala Ser Glu Asn Val Gly Thr Tyr Val Ser 
1               5                   10      
<210>  53
<211>  7
<212>  PRT
<213>  ˹
<220>
<223>  7F10 LCDR2Դhz7F10 LCDR2
<400>  53
Gly Ala Ser Asn Arg Tyr Thr 
1               5           
<210>  54
<211>  9
<212>  PRT
<213>  ˹
<220>
<223>  7F10 LCDR3Դhz7F10 LCDR3
<400>  54
Gly Gln Ser Tyr Ser Tyr Pro Tyr Thr 
1               5                   
<210>  55
<211>  17
<212>  PRT
<213>  ˹
<220>
<223>  3A10 HCDR2
<400>  55
Trp Ile Asp Pro Glu Asn Gly Glu Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      
Gly 
    
<210>  56
<211>  3
<212>  PRT
<213>  ˹
<220>
<223>  3A10 HCDR3
<400>  56
Phe Asp Tyr 
1           
<210>  57
<211>  16
<212>  PRT
<213>  ˹
<220>
<223>  3A10 LCDR1
<400>  57
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      
<210>  58
<211>  7
<212>  PRT
<213>  ˹
<220>
<223>  3A10 LCDR2
<400>  58
Leu Val Ser Lys Leu Asp Phe 
1               5           
<210>  59
<211>  9
<212>  PRT
<213>  ˹
<220>
<223>  3A10 LCDR3
<400>  59
Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   
<210>  60
<211>  5
<212>  PRT
<213>  ˹
<220>
<223>  10B4 HCDR1
<400>  60
Asn Tyr Gly Ile Ser 
1               5   
<210>  61
<211>  17
<212>  PRT
<213>  ˹
<220>
<223>  10B4 HCDR2
<400>  61
Glu Ile Tyr Pro Arg Gly Gly Asn Thr Tyr Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      
Gly 
    
<210>  62
<211>  15
<212>  PRT
<213>  ˹
<220>
<223>  10B4 HCDR3
<400>  62
Arg Ala Phe Tyr Tyr Phe Gly Ser Asn Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15  
<210>  63
<211>  17
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 HCDR2
<400>  63
Arg Ile Asn Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      
Gly 
    
<210>  64
<211>  17
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 HCDR2
<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  XaaAspAsn  
<400>  64
Arg Ile Xaa Pro Glu Asp Val Glu Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      
Gly 
    
<210>  65
<211>  11
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 LCDR1
<400>  65
Arg Ala Ser Glu Asn Val Gly Thr Tyr Val Ser 
1               5                   10      
<210>  66
<211>  7
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 LCDR2
<400>  66
Ala Ala Ser Asn Arg Tyr Thr 
1               5           
<210>  67
<211>  7
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 LCDR2
<400>  67
Gly Ala Ser Thr Arg Tyr Thr 
1               5           
<210>  68
<211>  11
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 LCDR1
<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  XaaLysArg
<400>  68
Xaa Ala Ser Glu Asn Val Gly Thr Tyr Val Ser 
1               5                   10      
<210>  69
<211>  7
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 LCDR2
<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  XaaGlyAla
<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  XaaAsnThr
<400>  69
Xaa Ala Ser Xaa Arg Tyr Thr 
1               5           
<210>  70
<211>  23
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR1
<400>  70
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              
<210>  71
<211>  23
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR1
<400>  71
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys 
            20              
<210>  72
<211>  15
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR2
<400>  72
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  
<210>  73
<211>  15
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR2
<400>  73
Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  
<210>  74
<211>  15
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR2
<400>  74
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  
<210>  75
<211>  15
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR2
<400>  75
Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  
<210>  76
<211>  32
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR3
<400>  76
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          
<210>  77
<211>  32
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR3
<400>  77
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          
<210>  78
<211>  32
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR3
<400>  78
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          
<210>  79
<211>  10
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR4
<400>  79
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  
<210>  80
<211>  30
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR1
<400>  80
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  
<210>  81
<211>  30
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR1
<400>  81
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  
<210>  82
<211>  30
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR1
<400>  82
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Lys 
            20                  25                  30 
<210>  83
<211>  30
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR1
<400>  83
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Asn Phe Thr 
            20                  25                  30  
<210>  84
<211>  30
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR1
<400>  84
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Asn Ile Lys 
            20                  25                  30  
<210>  85
<211>  14
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR2
<400>  85
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  
<210>  86
<211>  14
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR2
<400>  86
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  
<210>  87
<211>  32
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR3
<400>  87
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          
<210>  88
<211>  32
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR3
<400>  88
Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          
<210>  89
<211>  32
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR3
<400>  89
Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          
<210>  90
<211>  11
<212>  PRT
<213>  ˹
<220>
<223>  Դhz7F10 ɱFR4
<400>  90
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

