                         б

<110>  㽭念ԣҩ޹˾
       ҩҵɷ޹˾
 
<120>  һøӦϳ(1R,2R)-AMPPķ

<130>  6985-2213238IB

<150>  CN202110162637. 0
<151>  2021-02-05

<150>  CN202110567238.2
<151>  2021-05-24

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  663
<212>  PRT
<213>  ˹

<220>
<223>  󳦸˾תͪø

<400>  1

Met Ser Ser Arg Lys Glu Leu Ala Asn Ala Ile Arg Ala Leu Ser Met 
1               5                   10                  15      


Asp Ala Val Gln Lys Ala Lys Ser Gly His Pro Gly Ala Pro Met Gly 
            20                  25                  30          


Met Ala Asp Ile Ala Glu Val Leu Trp Arg Asp Phe Leu Lys His Asn 
        35                  40                  45              


Pro Gln Asn Pro Ser Trp Ala Asp Arg Asp Arg Phe Val Leu Ser Asn 
    50                  55                  60                  


Gly His Gly Ser Met Leu Ile Tyr Ser Leu Leu His Leu Thr Gly Tyr 
65                  70                  75                  80  


Asp Leu Pro Met Glu Glu Leu Lys Asn Phe Arg Gln Leu His Ser Lys 
                85                  90                  95      


Thr Pro Gly His Pro Glu Val Gly Tyr Thr Ala Gly Val Glu Thr Thr 
            100                 105                 110         


Thr Gly Pro Leu Gly Gln Gly Ile Ala Asn Ala Val Gly Met Ala Ile 
        115                 120                 125             


Ala Glu Lys Thr Leu Ala Ala Gln Phe Asn Arg Pro Gly His Asp Ile 
    130                 135                 140                 


Val Asp His Tyr Thr Tyr Ala Phe Met Gly Asp Gly Cys Met Met Glu 
145                 150                 155                 160 


Gly Ile Ser His Glu Val Cys Ser Leu Ala Gly Thr Leu Lys Leu Gly 
                165                 170                 175     


Lys Leu Ile Ala Phe Tyr Asp Asp Asn Gly Ile Ser Ile Asp Gly His 
            180                 185                 190         


Val Glu Gly Trp Phe Thr Asp Asp Thr Ala Met Arg Phe Glu Ala Tyr 
        195                 200                 205             


Gly Trp His Val Ile Arg Asp Ile Asp Gly His Asp Ala Ala Ser Ile 
    210                 215                 220                 


Lys Arg Ala Val Glu Glu Ala Arg Ala Val Thr Asp Lys Pro Ser Leu 
225                 230                 235                 240 


Leu Met Cys Lys Thr Ile Ile Gly Phe Gly Ser Pro Asn Lys Ala Gly 
                245                 250                 255     


Thr His Asp Ser His Gly Ala Pro Leu Gly Asp Ala Glu Ile Ala Leu 
            260                 265                 270         


Thr Arg Glu Gln Leu Gly Trp Lys Tyr Ala Pro Phe Glu Ile Pro Ser 
        275                 280                 285             


Glu Ile Tyr Ala Gln Trp Asp Ala Lys Glu Ala Gly Gln Ala Lys Glu 
    290                 295                 300                 


Ser Ala Trp Asn Glu Lys Phe Ala Ala Tyr Ala Lys Ala Tyr Pro Gln 
305                 310                 315                 320 


Glu Ala Ala Glu Phe Thr Arg Arg Met Lys Gly Glu Met Pro Ser Asp 
                325                 330                 335     


Phe Asp Ala Lys Ala Lys Glu Phe Ile Ala Lys Leu Gln Ala Asn Pro 
            340                 345                 350         


Ala Lys Ile Ala Ser Arg Lys Ala Ser Gln Asn Ala Ile Glu Ala Phe 
        355                 360                 365             


Gly Pro Leu Leu Pro Glu Phe Leu Gly Gly Ser Ala Asp Leu Ala Pro 
    370                 375                 380                 


Tyr Asn Leu Thr Leu Trp Ser Gly Ser Lys Ala Ile Asn Glu Asp Ala 
385                 390                 395                 400 


Ala Gly Asn Tyr Ile His Tyr Gly Val Arg Glu Phe Gly Met Thr Ala 
                405                 410                 415     


Ile Ala Asn Gly Ile Ser Leu His Gly Gly Phe Leu Pro Tyr Thr Ser 
            420                 425                 430         


Thr Phe Leu Met Phe Val Glu Tyr Ala Arg Asn Ala Val Arg Met Ala 
        435                 440                 445             


Ala Leu Met Lys Gln Arg Gln Val Met Val Tyr Thr His Asp Ser Ile 
    450                 455                 460                 


Gly Leu Gly Glu Thr Gly Pro Thr His Gln Pro Val Glu Gln Val Ala 
465                 470                 475                 480 


Ser Leu Arg Val Thr Pro Asn Met Ser Thr Trp Arg Pro Cys Asp Gln 
                485                 490                 495     


Val Glu Ser Ala Val Ala Trp Lys Tyr Gly Val Glu Arg Gln Asp Gly 
            500                 505                 510         


Pro Thr Ala Leu Ile Leu Ser Gln Gln Asn Leu Ala Gln Gln Glu Arg 
        515                 520                 525             


Thr Glu Glu Gln Leu Ala Asn Ile Ala Arg Gly Gly Tyr Val Leu Lys 
    530                 535                 540                 


Asp Cys Ala Gly Gln Pro Glu Leu Ile Phe Ile Ala Thr Gly Ser Glu 
545                 550                 555                 560 


Val Glu Leu Ala Val Ala Ala Tyr Glu Lys Leu Thr Ala Glu Gly Val 
                565                 570                 575     


Lys Ala Arg Val Val Ser Met Pro Ser Thr Asp Ala Phe Asp Lys Gln 
            580                 585                 590         


Asp Ala Ala Tyr Arg Glu Ser Val Leu Pro Lys Ala Val Thr Ala Arg 
        595                 600                 605             


Val Ala Val Glu Ala Gly Ile Ala Asp Tyr Trp Tyr Lys Tyr Val Gly 
    610                 615                 620                 


Leu Asn Gly Ala Ile Val Gly Met Thr Thr Phe Gly Glu Ser Ala Pro 
625                 630                 635                 640 


Ala Glu Leu Leu Phe Glu Glu Phe Gly Phe Thr Val Asp Asn Val Val 
                645                 650                 655     


Ala Lys Ala Lys Glu Leu Leu 
            660             


<210>  2
<211>  1992
<212>  DNA
<213>  ˹

<220>
<223>  󳦸˾תͪøĺ

<400>  2
atgtcctcac gtaaagagct tgccaatgct attcgtgcgc tgagcatgga cgcagtacag       60

aaagccaaat ccggtcaccc gggtgcccct atgggtatgg ctgacattgc cgaagtcctg      120

tggcgtgatt tcctgaaaca caacccgcag aatccgtcct gggctgaccg tgaccgcttc      180

gtgctgtcca acggccacgg ctccatgctg atctacagcc tgctgcacct caccggttac      240

gatctgccga tggaagaact gaaaaacttc cgtcagctgc actctaaaac tccgggtcac      300

ccggaagtgg gttacaccgc tggtgtggaa accaccaccg gtccgctggg tcagggtatt      360

gccaacgcag tcggtatggc gattgcagaa aaaacgctgg cggcgcagtt taaccgtccg      420

ggccacgaca ttgtcgacca ctacacctac gccttcatgg gcgacggctg catgatggaa      480

ggcatctccc acgaagtttg ctctctggcg ggtacgctga agctgggtaa actgattgca      540

ttctacgatg acaacggtat ttctatcgat ggtcacgttg aaggctggtt caccgacgac      600

accgcaatgc gtttcgaagc ttacggctgg cacgttattc gcgacatcga cggtcatgac      660

gcggcatcta tcaaacgcgc agtagaagaa gcgcgcgcag tgactgacaa accttccctg      720

ctgatgtgca aaaccatcat cggtttcggt tccccgaaca aagccggtac ccacgactcc      780

cacggtgcgc cgctgggcga cgctgaaatt gccctgaccc gcgaacaact gggctggaaa      840

tatgcgccgt tcgaaatccc gtctgaaatc tatgctcagt gggatgcgaa agaagcaggc      900

caggcgaaag aatccgcatg gaacgagaaa ttcgctgctt acgcgaaagc ttatccgcag      960

gaagccgctg aatttacccg ccgtatgaaa ggcgaaatgc cgtctgactt cgacgctaaa     1020

gcgaaagagt tcatcgctaa actgcaggct aatccggcga aaatcgccag ccgtaaagcg     1080

tctcagaatg ctatcgaagc gttcggtccg ctgttgccgg aattcctcgg cggttctgct     1140

gacctggcgc cgtataacct gaccctgtgg tctggttcta aagcaatcaa cgaagatgct     1200

gcgggtaact acatccacta cggtgttcgc gagttcggta tgaccgcgat tgctaacggt     1260

atctccctgc acggtggctt cctgccgtac acctccacct tcctgatgtt cgtggaatac     1320

gcacgtaacg ccgtacgtat ggctgcgctg atgaaacagc gtcaggtgat ggtttacacc     1380

cacgactcca tcggtctggg cgaaaccggc ccgactcacc agccggttga gcaggtcgct     1440

tctctgcgcg taaccccgaa catgtctaca tggcgtccgt gtgaccaggt tgaatccgcg     1500

gtcgcgtgga aatacggtgt tgagcgtcag gacggcccga ccgcactgat cctctcccaa     1560

cagaacctgg cgcagcagga acgaactgaa gagcaactgg caaacatcgc gcgcggtggt     1620

tatgtgctga aagactgcgc cggtcagccg gaactgattt tcatcgctac cggttcagaa     1680

gttgaactgg ctgttgctgc ctacgaaaaa ctgactgccg aaggcgtgaa agcgcgcgtg     1740

gtgtccatgc cgtctaccga cgcatttgac aagcaggatg ctgcttaccg tgaatccgta     1800

ctgccgaaag cggttactgc acgcgttgct gtagaagcgg gtattgctga ctactggtac     1860

aagtatgttg gcctgaacgg tgctatcgtc ggtatgacca ccttcggtga atctgctccg     1920

gcagagctgc tgtttgaaga gttcggcttc actgttgata acgttgttgc gaaagcaaaa     1980

gaactgctgt aa                                                         1992


<210>  3
<211>  330
<212>  PRT
<213>  ˹

<220>
<223>  תøATA117İ

<400>  3

Met Ala Phe Ser Ala Asp Thr Ser Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Tyr Leu His Ser Asp 
    50                  55                  60                  


Val Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Asp Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Met Arg Ile 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Gly Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Ala Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Ala Pro Leu Leu Leu Asp Gly Asp Gly Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Leu Ala Glu Leu 
            260                 265                 270         


Leu Asp Ala Asp Glu Val Leu Gly Cys Thr Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Pro Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Ser Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  4
<211>  990
<212>  DNA
<213>  ˹

<220>
<223>  תøATA117ĺ

<400>  4
atggcattta gcgcggatac cagcgaaatc gtctataccc acgataccgg tctggattac       60

atcacctaca gcgattacga actggatccg gcaaatccgt tagcaggcgg cgcagcttgg      120

attgaaggcg catttgttcc gccgtctgaa gcgcgtatta gcatcttcga tcagggctat      180

ctgcatagcg acgttaccta taccgtcttc cacgtttgga acggtaacgc atttcgtctg      240

gacgatcaca tcgaacgtct gttcagcaac gccgaaagta tgcgtattat tccgccgctg      300

acccaagacg aagtcaaaga aatcgcgctg gaactggttg caaaaaccga actgcgcgaa      360

gcgtttgtta gcgttagcat tacccgcggt tatagtagta ccccgggcga acgcgatatt      420

accaaacatc gtccgcaggt ctacatgtac gctgttccgt accagtggat cgttccgttt      480

gatcgtattc gcgacggcgt tcacgcaatg gttgcacaga gcgtgcgtcg taccccgcgt      540

agcagcatcg atccgcaggt caaaaacttc cagtggggcg atttaattcg cgcagttcag      600

gaaacccacg atcgcggttt tgaagcaccg ttactgttag acggcgacgg tttactggca      660

gaaggtagcg gctttaacgt cgtcgtcatt aaagatgggg ttgttcgttc tccgggtcgt      720

gcagcattac cgggtattac ccgcaaaacc gttctggaaa ttgcggaatc cctgggtcat      780

gaagcgattc tggcggatat taccttagcg gaactgctgg acgcagacga agttttaggt      840

tgtaccaccg ctggcggcgt ttggccgttt gttagcgttg acggcaatcc gattagcgat      900

ggtgttccgg gtccggttac ccaaagcatt attcgtcgct actgggagct gaacgttgaa      960

agtagcagcc tgttaacccc ggttcagtat                                       990


<210>  5
<211>  1992
<212>  DNA
<213>  ˹

<220>
<223>  תͪøEcTK1_YYHĺ

<400>  5
atgtcctcac gtaaagagct tgccaatgct attcgtgcgc tgagcatgga cgcagtacag       60

aaagccaaat ccggttatcc gggtgcccct atgggtatgg ctgacattgc cgaagtcctg      120

tggcgtgatt tcctgaaaca caacccgcag aatccgtcct gggctgaccg tgaccgcttc      180

gtgctgtcca acggccacgg ctccatgctg atctacagcc tgctgcacct caccggttac      240

gatctgccga tggaagaact gaaaaacttc cgtcagctgc actctaaaac tccgggtcac      300

ccggaagtgg gttacaccgc tggtgtggaa accaccaccg gtccgctggg tcagggtatt      360

gccaacgcag tcggtatggc gattgcagaa aaaacgctgg cggcgcagtt taaccgtccg      420

ggccacgaca ttgtcgacca ctacacctac gccttcatgg gcgacggctg catgatggaa      480

ggcatctccc acgaagtttg ctctctggcg ggtacgctga agttgggtaa actgattgca      540

ttctacgatg acaacggtat ttctatcgat ggtcacgttg aaggctggtt caccgacgac      600

accgcaatgc gtttcgaagc ttacggctgg cacgttattc gcgacatcga cggtcatgac      660

gcggcatcta tcaaacgcgc agtagaagaa gcgcgcgcag tgactgacaa accttccctg      720

ctgatgtgca aaaccatcat cggtttcggt tccccgaaca aagccggtac ccacgactcc      780

cacggtgcgc cgctgggcga cgctgaaatt gccctgaccc gcgaacaact gggctggaaa      840

tatgcgccgt tcgaaatccc gtctgaaatc tatgctcagt gggatgcgaa agaagcaggc      900

caggcgaaag aatccgcatg gaacgagaaa ttcgctgctt acgcgaaagc ttatccgcag      960

gaagccgctg aatttacccg ccgtatgaaa ggcgaaatgc cgtctgactt cgacgctaaa     1020

gcgaaagagt tcatcgctaa actgcaggct aatccggcga aaatcgccag ccgtaaagcg     1080

tctcagaatg ctatcgaagc gttcggtccg ctgttgccgg aattcctcgg cggttctgct     1140

gacctggcgc cgtataacct gaccctgtgg tctggttcta aagcaatcaa cgaagatgct     1200

gcgggtaact acatccacta cggtgttcgc gagttcggta tgaccgcgat tgctaacggt     1260

atctccctgc acggtggctt cctgccgtac acctccacct atctgatgtt cgtggaatac     1320

gcacgtaacg ccgtacgtat ggctgcgctg atgaaacagc gtcaggtgat ggtttacacc     1380

cacgactcca tcggtcatgg cgaaaccggc ccgactcacc agccggttga gcaggtcgct     1440

tctctgcgcg taaccccgaa catgtctaca tggcgtccgt gtgaccaggt tgaatccgcg     1500

gtcgcgtgga aatacggtgt tgagcgtcag gacggcccga ccgcactgat cctctcccaa     1560

cagaacctgg cgcagcagga acgaactgaa gagcaactgg caaacatcgc gcgcggtggt     1620

tatgtgctga aagactgcgc cggtcagccg gaactgattt tcatcgctac cggttcagaa     1680

gttgaactgg ctgttgctgc ctacgaaaaa ctgactgccg aaggcgtgaa agcgcgcgtg     1740

gtgtccatgc cgtctaccga cgcatttgac aagcaggatg ctgcttaccg tgaatccgta     1800

ctgccgaaag cggttactgc acgcgttgct gtagaagcgg gtattgctga ctactggtac     1860

aagtatgttg gcctgaacgg tgctatcgtc ggtatgacca ccttcggtga atctgctccg     1920

gcagagctgc tgtttgaaga gttcggcttc actgttgata acgttgttgc gaaagcaaaa     1980

gaactgctgt aa                                                         1992


<210>  6
<211>  993
<212>  DNA
<213>  ˹

<220>
<223>  תøATA117_ACHHĺ

<400>  6
atggcattta gcgcggatac cagcgaaatc gtctataccc acgataccgg tctggattac       60

atcacctaca gcgattacga actggatccg gcaaatccgt tagcaggcgg cgcagcttgg      120

attgaaggcg catttgttcc gccgtctgaa gcgcgtatta gcatcttcga tcagggctat      180

ctgcatagcg acgttaccta taccgcattc cacgtttgga acggtaacgc atttcgtctg      240

gacgatcaca tcgaacgtct gttcagcaac gccgaaagta tgcgtattat tccgccgctg      300

acccaagacg aagtcaaaga aatcgcgctg gaactggttg caaaaaccga actgcgcgaa      360

gcgtgtgtta gcgttagcat tacccgcggt tatagtagta ccccgggcga acgcgatatt      420

accaaacatc gtccgcaggt ctacatgtac gctgttccgt accagtggca tgttccgttt      480

gatcgtattc gcgacggcgt tcacgcaatg gttgcacaga gcgtgcgtcg taccccgcgt      540

agcagcatcg atccgcaggt caaaaacttc cagtggggcg atttaattcg cgcagttcag      600

gaaacccacg atcgcggttt tgaagcaccg ttactgttag acggcgacgg tttactggca      660

gaaggtagcg gccataacgt cgtcgtcatt aaagatgggg ttgttcgttc tccgggtcgt      720

gcagcattac cgggtattac ccgcaaaacc gttctggaaa ttgcggaatc cctgggtcat      780

gaagcgattc tggcggatat taccttagcg gaactgctgg acgcagacga agttttaggt      840

tgtaccaccg ctggcggcgt ttggccgttt gttagcgttg acggcaatcc gattagcgat      900

ggtgttccgg gtccggttac ccaaagcatt attcgtcgct actgggagct gaacgttgaa      960

agtagcagcc tgttaacccc ggttcagtat taa                                   993


<210>  7
<211>  663
<212>  PRT
<213>  ˹

<220>
<223>  תͪøEcTK1_YYHİ

<400>  7

Met Ser Ser Arg Lys Glu Leu Ala Asn Ala Ile Arg Ala Leu Ser Met 
1               5                   10                  15      


Asp Ala Val Gln Lys Ala Lys Ser Gly Tyr Pro Gly Ala Pro Met Gly 
            20                  25                  30          


Met Ala Asp Ile Ala Glu Val Leu Trp Arg Asp Phe Leu Lys His Asn 
        35                  40                  45              


Pro Gln Asn Pro Ser Trp Ala Asp Arg Asp Arg Phe Val Leu Ser Asn 
    50                  55                  60                  


Gly His Gly Ser Met Leu Ile Tyr Ser Leu Leu His Leu Thr Gly Tyr 
65                  70                  75                  80  


Asp Leu Pro Met Glu Glu Leu Lys Asn Phe Arg Gln Leu His Ser Lys 
                85                  90                  95      


Thr Pro Gly His Pro Glu Val Gly Tyr Thr Ala Gly Val Glu Thr Thr 
            100                 105                 110         


Thr Gly Pro Leu Gly Gln Gly Ile Ala Asn Ala Val Gly Met Ala Ile 
        115                 120                 125             


Ala Glu Lys Thr Leu Ala Ala Gln Phe Asn Arg Pro Gly His Asp Ile 
    130                 135                 140                 


Val Asp His Tyr Thr Tyr Ala Phe Met Gly Asp Gly Cys Met Met Glu 
145                 150                 155                 160 


Gly Ile Ser His Glu Val Cys Ser Leu Ala Gly Thr Leu Lys Leu Gly 
                165                 170                 175     


Lys Leu Ile Ala Phe Tyr Asp Asp Asn Gly Ile Ser Ile Asp Gly His 
            180                 185                 190         


Val Glu Gly Trp Phe Thr Asp Asp Thr Ala Met Arg Phe Glu Ala Tyr 
        195                 200                 205             


Gly Trp His Val Ile Arg Asp Ile Asp Gly His Asp Ala Ala Ser Ile 
    210                 215                 220                 


Lys Arg Ala Val Glu Glu Ala Arg Ala Val Thr Asp Lys Pro Ser Leu 
225                 230                 235                 240 


Leu Met Cys Lys Thr Ile Ile Gly Phe Gly Ser Pro Asn Lys Ala Gly 
                245                 250                 255     


Thr His Asp Ser His Gly Ala Pro Leu Gly Asp Ala Glu Ile Ala Leu 
            260                 265                 270         


Thr Arg Glu Gln Leu Gly Trp Lys Tyr Ala Pro Phe Glu Ile Pro Ser 
        275                 280                 285             


Glu Ile Tyr Ala Gln Trp Asp Ala Lys Glu Ala Gly Gln Ala Lys Glu 
    290                 295                 300                 


Ser Ala Trp Asn Glu Lys Phe Ala Ala Tyr Ala Lys Ala Tyr Pro Gln 
305                 310                 315                 320 


Glu Ala Ala Glu Phe Thr Arg Arg Met Lys Gly Glu Met Pro Ser Asp 
                325                 330                 335     


Phe Asp Ala Lys Ala Lys Glu Phe Ile Ala Lys Leu Gln Ala Asn Pro 
            340                 345                 350         


Ala Lys Ile Ala Ser Arg Lys Ala Ser Gln Asn Ala Ile Glu Ala Phe 
        355                 360                 365             


Gly Pro Leu Leu Pro Glu Phe Leu Gly Gly Ser Ala Asp Leu Ala Pro 
    370                 375                 380                 


Tyr Asn Leu Thr Leu Trp Ser Gly Ser Lys Ala Ile Asn Glu Asp Ala 
385                 390                 395                 400 


Ala Gly Asn Tyr Ile His Tyr Gly Val Arg Glu Phe Gly Met Thr Ala 
                405                 410                 415     


Ile Ala Asn Gly Ile Ser Leu His Gly Gly Phe Leu Pro Tyr Thr Ser 
            420                 425                 430         


Thr Tyr Leu Met Phe Val Glu Tyr Ala Arg Asn Ala Val Arg Met Ala 
        435                 440                 445             


Ala Leu Met Lys Gln Arg Gln Val Met Val Tyr Thr His Asp Ser Ile 
    450                 455                 460                 


Gly His Gly Glu Thr Gly Pro Thr His Gln Pro Val Glu Gln Val Ala 
465                 470                 475                 480 


Ser Leu Arg Val Thr Pro Asn Met Ser Thr Trp Arg Pro Cys Asp Gln 
                485                 490                 495     


Val Glu Ser Ala Val Ala Trp Lys Tyr Gly Val Glu Arg Gln Asp Gly 
            500                 505                 510         


Pro Thr Ala Leu Ile Leu Ser Gln Gln Asn Leu Ala Gln Gln Glu Arg 
        515                 520                 525             


Thr Glu Glu Gln Leu Ala Asn Ile Ala Arg Gly Gly Tyr Val Leu Lys 
    530                 535                 540                 


Asp Cys Ala Gly Gln Pro Glu Leu Ile Phe Ile Ala Thr Gly Ser Glu 
545                 550                 555                 560 


Val Glu Leu Ala Val Ala Ala Tyr Glu Lys Leu Thr Ala Glu Gly Val 
                565                 570                 575     


Lys Ala Arg Val Val Ser Met Pro Ser Thr Asp Ala Phe Asp Lys Gln 
            580                 585                 590         


Asp Ala Ala Tyr Arg Glu Ser Val Leu Pro Lys Ala Val Thr Ala Arg 
        595                 600                 605             


Val Ala Val Glu Ala Gly Ile Ala Asp Tyr Trp Tyr Lys Tyr Val Gly 
    610                 615                 620                 


Leu Asn Gly Ala Ile Val Gly Met Thr Thr Phe Gly Glu Ser Ala Pro 
625                 630                 635                 640 


Ala Glu Leu Leu Phe Glu Glu Phe Gly Phe Thr Val Asp Asn Val Val 
                645                 650                 655     


Ala Lys Ala Lys Glu Leu Leu 
            660             


<210>  8
<211>  330
<212>  PRT
<213>  ˹

<220>
<223>  תøATA117_ACHHİ

<400>  8

Met Ala Phe Ser Ala Asp Thr Ser Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Tyr Leu His Ser Asp 
    50                  55                  60                  


Val Thr Tyr Thr Ala Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Asp Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Met Arg Ile 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Cys Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Gly Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp His Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Ala Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Ala Pro Leu Leu Leu Asp Gly Asp Gly Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 


His Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Leu Ala Glu Leu 
            260                 265                 270         


Leu Asp Ala Asp Glu Val Leu Gly Cys Thr Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Pro Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Ser Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


