                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  COMPOSITIONS AND METHOD OF USE OF MUTANT ACE2 DECOY VARIANTS

<130>  UPN-22-9971.PCT

<150>   US 63/143,614
<151>  2021-01-29

<150>  US 63/160,511
<151>  2021-03-12

<150>  US 63/166,686
<151>  2021-03-26

<150>  US 63/215,159
<151>  2021-06-25

<150>  US 63/253,654
<151>  2021-10-08

<150>  US 63/300,154
<151>  2022-01-17

<160>  127   

<170>  PatentIn version 3.5

<210>  1
<211>  2535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-variant1-IgG4 nucleic acid sequence

<400>  1
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac atgtttaacc acaaagccga agacctgttc      120

tatcaaagtt cacttgctgc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata acgctgggga caaatggtct gcctttttaa aggaacagtc cacatttgcc      240

caaatgtatc cactacaaga aattcagaat cccacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccggataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcgagagcaa accattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc ccttcggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaatat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagacgagtc taagtacggc     1860

cctccttgtc cttcctgccc cgctcctgaa tttctcggcg gaccttccgt gttcctgttt     1920

cctccaaagc ctaaggacac cctgatgatc agcagaaccc ctgaagtgac ctgcgtggtg     1980

gtggacgtgt cccaagagga tcctgaggtg cagttcaatt ggtacgtcga cggcgtggaa     2040

gtgcacaacg ccaagaccaa gcctagagag gaacagttca acagcaccta cagagtggtg     2100

tccgtgctga ccgtgctgca ccaggattgg ctgaacggca aagagtacaa gtgcaaggtg     2160

tccaacaagg gcctgccaag cagcatcgag aaaaccatca gcaaggccaa gggccagcct     2220

agggaacccc aggtttacac actgcctcca agccaagagg aaatgaccaa gaaccaggtg     2280

tccctgacct gcctggtcaa gggcttctac ccttccgata tcgccgtgga atgggagagc     2340

aacggccagc ctgagaacaa ctacaagacc acacctcctg tgctggacag cgacggctca     2400

ttcttcctgt actcccggct gaccgtggac aagtccagat ggcaagaggg caacgtgttc     2460

agctgcagcg tgatgcacga ggccctgcac aatcactaca cccagaagtc cctgagtctg     2520

agcctgggca agtga                                                      2535


<210>  2
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2-variant1-IgG4amino acid sequence

<400>  2

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    610                 615                 620                 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            740                 745                 750         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        835                 840                 


<210>  3
<211>  2535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-variant2-IgG4 nucleic acid sequence

<400>  3
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac atgtttaacc acaaagccga agacctgttc      120

tatcaaagtt cacttgctgc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata acgctgggga caaatggtct gcctttttaa aggaacagtc cacatttgcc      240

caaatgtatc cactacaaga aattcagaat cccacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccggataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcgagagcaa accattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc ccttcggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaatat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccttcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagacgagtc taagtacggc     1860

cctccttgtc cttcctgccc cgctcctgaa tttctcggcg gaccttccgt gttcctgttt     1920

cctccaaagc ctaaggacac cctgatgatc agcagaaccc ctgaagtgac ctgcgtggtg     1980

gtggacgtgt cccaagagga tcctgaggtg cagttcaatt ggtacgtcga cggcgtggaa     2040

gtgcacaacg ccaagaccaa gcctagagag gaacagttca acagcaccta cagagtggtg     2100

tccgtgctga ccgtgctgca ccaggattgg ctgaacggca aagagtacaa gtgcaaggtg     2160

tccaacaagg gcctgccaag cagcatcgag aaaaccatca gcaaggccaa gggccagcct     2220

agggaacccc aggtttacac actgcctcca agccaagagg aaatgaccaa gaaccaggtg     2280

tccctgacct gcctggtcaa gggcttctac ccttccgata tcgccgtgga atgggagagc     2340

aacggccagc ctgagaacaa ctacaagacc acacctcctg tgctggacag cgacggctca     2400

ttcttcctgt actcccggct gaccgtggac aagtccagat ggcaagaggg caacgtgttc     2460

agctgcagcg tgatgcacga ggccctgcac aatcactaca cccagaagtc cctgagtctg     2520

agcctgggca agtga                                                      2535


<210>  4
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2-variant2-IgG4amino acid sequence

<400>  4

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    610                 615                 620                 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            740                 745                 750         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        835                 840                 


<210>  5
<211>  2535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-variant3-IgG4 nucleic acid sequence

<400>  5
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aggtttaacc acgtagccga agacccgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata tcactgaaga gaatgcccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacatttgcc      240

caaatgtatc cactacaaga aattcaggac ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccggataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcgagagcaa accattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc ccttcggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaatat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagacgagtc taagtacggc     1860

cctccttgtc cttcctgccc cgctcctgaa tttctcggcg gaccttccgt gttcctgttt     1920

cctccaaagc ctaaggacac cctgatgatc agcagaaccc ctgaagtgac ctgcgtggtg     1980

gtggacgtgt cccaagagga tcctgaggtg cagttcaatt ggtacgtcga cggcgtggaa     2040

gtgcacaacg ccaagaccaa gcctagagag gaacagttca acagcaccta cagagtggtg     2100

tccgtgctga ccgtgctgca ccaggattgg ctgaacggca aagagtacaa gtgcaaggtg     2160

tccaacaagg gcctgccaag cagcatcgag aaaaccatca gcaaggccaa gggccagcct     2220

agggaacccc aggtttacac actgcctcca agccaagagg aaatgaccaa gaaccaggtg     2280

tccctgacct gcctggtcaa gggcttctac ccttccgata tcgccgtgga atgggagagc     2340

aacggccagc ctgagaacaa ctacaagacc acacctcctg tgctggacag cgacggctca     2400

ttcttcctgt actcccggct gaccgtggac aagtccagat ggcaagaggg caacgtgttc     2460

agctgcagcg tgatgcacga ggccctgcac aatcactaca cccagaagtc cctgagtctg     2520

agcctgggca agtga                                                      2535


<210>  6
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2-variant3-IgG4amino acid sequence

<400>  6

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Arg Phe 
            20                  25                  30          


Asn His Val Ala Glu Asp Pro Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Ala Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    610                 615                 620                 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            740                 745                 750         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        835                 840                 


<210>  7
<211>  2535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-variant4-IgG4 nucleic acid sequence

<400>  7
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac atgtttaacc acaaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacaattgcc      240

caaatgtatc cactacaaga aattcagaat cccacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccggataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcgagagcaa accattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc ccttcggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaatat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagacgagtc taagtacggc     1860

cctccttgtc cttcctgccc cgctcctgaa tttctcggcg gaccttccgt gttcctgttt     1920

cctccaaagc ctaaggacac cctgatgatc agcagaaccc ctgaagtgac ctgcgtggtg     1980

gtggacgtgt cccaagagga tcctgaggtg cagttcaatt ggtacgtcga cggcgtggaa     2040

gtgcacaacg ccaagaccaa gcctagagag gaacagttca acagcaccta cagagtggtg     2100

tccgtgctga ccgtgctgca ccaggattgg ctgaacggca aagagtacaa gtgcaaggtg     2160

tccaacaagg gcctgccaag cagcatcgag aaaaccatca gcaaggccaa gggccagcct     2220

agggaacccc aggtttacac actgcctcca agccaagagg aaatgaccaa gaaccaggtg     2280

tccctgacct gcctggtcaa gggcttctac ccttccgata tcgccgtgga atgggagagc     2340

aacggccagc ctgagaacaa ctacaagacc acacctcctg tgctggacag cgacggctca     2400

ttcttcctgt actcccggct gaccgtggac aagtccagat ggcaagaggg caacgtgttc     2460

agctgcagcg tgatgcacga ggccctgcac aatcactaca cccagaagtc cctgagtctg     2520

agcctgggca agtga                                                      2535


<210>  8
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2-variant4-IgG4amino acid sequence

<400>  8

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Ile Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    610                 615                 620                 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            740                 745                 750         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        835                 840                 


<210>  9
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 1 nucleic acid sequence

<400>  9
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac atgtttaacc acaaagccga agacctgttc      120

tatcaaagtt cacttgctgc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata acgctgggga caaatggtct gcctttttaa aggaacagtc cacatttgcc      240

caaatgtatc cactacaaga aattcagaat cccacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccggataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcgagagcaa accattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc ccttcggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaatat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagac                     1845


<210>  10
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 1 amino acid sequence

<400>  10

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  11
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 2 nucleic acid sequence

<400>  11
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac atgtttaacc acaaagccga agacctgttc      120

tatcaaagtt cacttgctgc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata acgctgggga caaatggtct gcctttttaa aggaacagtc cacatttgcc      240

caaatgtatc cactacaaga aattcagaat cccacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccggataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcgagagcaa accattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc ccttcggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaatat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccttcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagac                     1845


<210>  12
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 2 amino acid sequence

<400>  12

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  13
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 3 nucleic acid sequence

<400>  13
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aggtttaacc acgtagccga agacccgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata tcactgaaga gaatgcccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacatttgcc      240

caaatgtatc cactacaaga aattcaggac ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccggataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcgagagcaa accattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc ccttcggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaatat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagac                     1845


<210>  14
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 3 amino acid sequence

<400>  14

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Arg Phe 
            20                  25                  30          


Asn His Val Ala Glu Asp Pro Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Ala Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  15
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 4 nucleic acid sequence

<400>  15
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac atgtttaacc acaaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacaattgcc      240

caaatgtatc cactacaaga aattcagaat cccacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccggataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcgagagcaa accattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc ccttcggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaatat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagac                     1845


<210>  16
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 4 amino acid sequence

<400>  16

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Ile Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  17
<211>  4884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid comprising vector genome encoding hAce2(variant 
       1)-IgG4-FC


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE enhancer

<220>
<221>  misc_feature
<222>  (198)..(579)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1942)..(3786)
<223>  hAce2 (variant 1) (GTP14)

<220>
<221>  misc_feature
<222>  (1942)..(1992)
<223>  ACE2 signal peptide

<220>
<221>  CDS
<222>  (1942)..(4473)
<223>  hAce2(Variant 1)(GTP14)-IgG4

<220>
<221>  misc_feature
<222>  (3787)..(4473)
<223>  human IgG4 Fc

<220>
<221>  polyA_signal
<222>  (4540)..(4666)
<223>  rabbit globin polyA

<220>
<221>  repeat_region
<222>  (4755)..(4884)
<223>  3'ITR

<400>  17
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcccgccac c atg tca agc tct tcc tgg ctc ctt ctc agc       1971
                        Met Ser Ser Ser Ser Trp Leu Leu Leu Ser           
                        1               5                   10            

ctt gtt gct gta act gct gct cag tcc acc att gag gaa cag gcc aag       2019
Leu Val Ala Val Thr Ala Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys           
                15                  20                  25                

aca ttt ttg gac atg ttt aac cac aaa gcc gaa gac ctg ttc tat caa       2067
Thr Phe Leu Asp Met Phe Asn His Lys Ala Glu Asp Leu Phe Tyr Gln           
            30                  35                  40                    

agt tca ctt gct gct tgg aat tat aac acc aat att act gaa gag aat       2115
Ser Ser Leu Ala Ala Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn           
        45                  50                  55                        

gtc caa aac atg aat aac gct ggg gac aaa tgg tct gcc ttt tta aag       2163
Val Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys           
    60                  65                  70                            

gaa cag tcc aca ttt gcc caa atg tat cca cta caa gaa att cag aat       2211
Glu Gln Ser Thr Phe Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn           
75                  80                  85                  90            

ccc aca gtc aag ctt cag ctg cag gct ctt cag caa aat ggg tct tca       2259
Pro Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser           
                95                  100                 105               

gtg ctc tca gaa gac aag agc aaa cgg ttg aac aca att cta aat aca       2307
Val Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr           
            110                 115                 120                   

atg agc acc atc tac agt act gga aaa gtt tgt aac ccg gat aat cca       2355
Met Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro           
        125                 130                 135                       

caa gaa tgc tta tta ctt gaa cca ggt ttg aat gaa ata atg gca aac       2403
Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn           
    140                 145                 150                           

agt tta gac tac aat gag agg ctc tgg gct tgg gaa agc tgg aga tct       2451
Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser           
155                 160                 165                 170           

gag gtc ggc aag cag ctg agg cca tta tat gaa gag tat gtg gtc ttg       2499
Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu           
                175                 180                 185               

aaa aat gag atg gcg aga gca aac cat tat gag gac tat ggg gat tat       2547
Lys Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr           
            190                 195                 200                   

tgg aga gga gac tat gaa gta aat ggg gta gat ggc tat gac tac agc       2595
Trp Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser           
        205                 210                 215                       

cgc ggc cag ttg att gaa gat gtg gaa cat acc ttt gaa gag att aaa       2643
Arg Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys           
    220                 225                 230                           

cca tta tat gaa cat ctt cat gcc tat gtg agg gca aag ttg atg aat       2691
Pro Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn           
235                 240                 245                 250           

gcc tat cct tcc tat atc agt cca att gga tgc ctc cct gct cat ttg       2739
Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu           
                255                 260                 265               

ctt ggt gat atg tgg ggt aga ttt tgg aca aat ctg tac tct ttg aca       2787
Leu Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr           
            270                 275                 280                   

gtt ccc ttc gga cag aaa cca aac ata gat gtt act gat gca atg gtg       2835
Val Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val           
        285                 290                 295                       

gac cag gcc tgg gat gca cag aga ata ttc aag gag gcc gag aag ttc       2883
Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe           
    300                 305                 310                           

ttt gta tct gtt ggt ctt cct aat atg act caa gga ttc tgg gaa tat       2931
Phe Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr           
315                 320                 325                 330           

tcc atg cta acg gac cca gga aat gtt cag aaa gca gtc tgc cat ccc       2979
Ser Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro           
                335                 340                 345               

aca gct tgg gac ctg ggg aag ggc gac ttc agg atc ctt atg tgc aca       3027
Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr           
            350                 355                 360                   

aag gtg aca atg gac gac ttc ctg aca gct cat cat gag atg ggg cat       3075
Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His           
        365                 370                 375                       

atc cag tat gat atg gca tat gct gca caa cct ttt ctg cta aga aat       3123
Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn           
    380                 385                 390                           

gga gct aat gaa gga ttc cat gaa gct gtt ggg gaa atc atg tca ctt       3171
Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu           
395                 400                 405                 410           

tct gca gcc aca cct aag cat tta aaa tcc att ggt ctt ctg tca ccc       3219
Ser Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro           
                415                 420                 425               

gat ttt caa gaa gac aat gaa aca gaa ata aac ttc ctg ctc aaa caa       3267
Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln           
            430                 435                 440                   

gca ctc acg att gtt ggg act ctg cca ttt act tac atg tta gag aag       3315
Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys           
        445                 450                 455                       

tgg agg tgg atg gtc ttt aaa ggg gaa att ccc aaa gac cag tgg atg       3363
Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met           
    460                 465                 470                           

aaa aag tgg tgg gag atg aag cga gag ata gtt ggg gtg gtg gaa cct       3411
Lys Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro           
475                 480                 485                 490           

gtg ccc cat gat gaa aca tac tgt gac ccc gca tct ctg ttc cat gtt       3459
Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val           
                495                 500                 505               

tct aat gat tac tca ttc att cga tat tac aca agg acc ctt tac caa       3507
Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln           
            510                 515                 520                   

ttc cag ttt caa gaa gca ctt tgt caa gca gct aaa cat gaa ggc cct       3555
Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro           
        525                 530                 535                       

ctg cac aaa tgt gac atc tca aac tct aca gaa gct gga cag aaa ctg       3603
Leu His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu           
    540                 545                 550                           

ttc aat atg ctg agg ctt gga aaa tca gaa ccc tgg acc cta gca ttg       3651
Phe Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu           
555                 560                 565                 570           

gaa aat gtt gta gga gca aag aac atg aat gta agg cca ctg ctc aac       3699
Glu Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn           
                575                 580                 585               

tac ttt gag ccc tta ttt acc tgg ctg aaa gac cag aac aag aat tct       3747
Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser           
            590                 595                 600                   

ttt gtg gga tgg agt acc gac tgg agt cca tat gca gac gag tct aag       3795
Phe Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys           
        605                 610                 615                       

tac ggc cct cct tgt cct tcc tgc ccc gct cct gaa ttt ctc ggc gga       3843
Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly           
    620                 625                 630                           

cct tcc gtg ttc ctg ttt cct cca aag cct aag gac acc ctg atg atc       3891
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
635                 640                 645                 650           

agc aga acc cct gaa gtg acc tgc gtg gtg gtg gac gtg tcc caa gag       3939
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu           
                655                 660                 665               

gat cct gag gtg cag ttc aat tgg tac gtc gac ggc gtg gaa gtg cac       3987
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
            670                 675                 680                   

aac gcc aag acc aag cct aga gag gaa cag ttc aac agc acc tac aga       4035
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg           
        685                 690                 695                       

gtg gtg tcc gtg ctg acc gtg ctg cac cag gat tgg ctg aac ggc aaa       4083
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys           
    700                 705                 710                           

gag tac aag tgc aag gtg tcc aac aag ggc ctg cca agc agc atc gag       4131
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu           
715                 720                 725                 730           

aaa acc atc agc aag gcc aag ggc cag cct agg gaa ccc cag gtt tac       4179
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
                735                 740                 745               

aca ctg cct cca agc caa gag gaa atg acc aag aac cag gtg tcc ctg       4227
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
            750                 755                 760                   

acc tgc ctg gtc aag ggc ttc tac cct tcc gat atc gcc gtg gaa tgg       4275
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
        765                 770                 775                       

gag agc aac ggc cag cct gag aac aac tac aag acc aca cct cct gtg       4323
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val           
    780                 785                 790                           

ctg gac agc gac ggc tca ttc ttc ctg tac tcc cgg ctg acc gtg gac       4371
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp           
795                 800                 805                 810           

aag tcc aga tgg caa gag ggc aac gtg ttc agc tgc agc gtg atg cac       4419
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His           
                815                 820                 825               

gag gcc ctg cac aat cac tac acc cag aag tcc ctg agt ctg agc ctg       4467
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu           
            830                 835                 840                   

ggc aag tgatgaggta cctctagagt cgacccgggc ggcctcgagg acggggtgaa        4523
Gly Lys                                                                   
                                                                          

ctacgcctga ggatccgatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc     4583

ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg     4643

gaattttttg tgtctctcac tcggaagcaa ttcgttgatc tgaatttcga ccacccataa     4703

tacccattac cctggtagat aagtagcatg gcgggttaat cattaactac aaggaacccc     4763

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     4823

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     4883

g                                                                     4884


<210>  18
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    610                 615                 620                 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            740                 745                 750         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        835                 840                 


<210>  19
<211>  4884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid comprising vector genome encoding hAce2(variant 
       2)-IgG4-FC


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE enhancer

<220>
<221>  misc_feature
<222>  (198)..(863)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  Chicken beta actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1942)..(3786)
<223>  hAce(variant 2)(GTP14HL)

<220>
<221>  misc_feature
<222>  (1942)..(1992)
<223>  ACE2 signal peptide

<220>
<221>  CDS
<222>  (1942)..(4473)
<223>  hAce2(variant 2)(GTP14HL)-IgG4

<220>
<221>  misc_feature
<222>  (3787)..(4473)
<223>  human IgG4 FC

<220>
<221>  polyA_signal
<222>  (4540)..(4666)
<223>  Rabbit globin poly A

<220>
<221>  repeat_region
<222>  (4755)..(4884)
<223>  3'ITR

<400>  19
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcccgccac c atg tca agc tct tcc tgg ctc ctt ctc agc       1971
                        Met Ser Ser Ser Ser Trp Leu Leu Leu Ser           
                        1               5                   10            

ctt gtt gct gta act gct gct cag tcc acc att gag gaa cag gcc aag       2019
Leu Val Ala Val Thr Ala Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys           
                15                  20                  25                

aca ttt ttg gac atg ttt aac cac aaa gcc gaa gac ctg ttc tat caa       2067
Thr Phe Leu Asp Met Phe Asn His Lys Ala Glu Asp Leu Phe Tyr Gln           
            30                  35                  40                    

agt tca ctt gct gct tgg aat tat aac acc aat att act gaa gag aat       2115
Ser Ser Leu Ala Ala Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn           
        45                  50                  55                        

gtc caa aac atg aat aac gct ggg gac aaa tgg tct gcc ttt tta aag       2163
Val Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys           
    60                  65                  70                            

gaa cag tcc aca ttt gcc caa atg tat cca cta caa gaa att cag aat       2211
Glu Gln Ser Thr Phe Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn           
75                  80                  85                  90            

ccc aca gtc aag ctt cag ctg cag gct ctt cag caa aat ggg tct tca       2259
Pro Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser           
                95                  100                 105               

gtg ctc tca gaa gac aag agc aaa cgg ttg aac aca att cta aat aca       2307
Val Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr           
            110                 115                 120                   

atg agc acc atc tac agt act gga aaa gtt tgt aac ccg gat aat cca       2355
Met Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro           
        125                 130                 135                       

caa gaa tgc tta tta ctt gaa cca ggt ttg aat gaa ata atg gca aac       2403
Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn           
    140                 145                 150                           

agt tta gac tac aat gag agg ctc tgg gct tgg gaa agc tgg aga tct       2451
Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser           
155                 160                 165                 170           

gag gtc ggc aag cag ctg agg cca tta tat gaa gag tat gtg gtc ttg       2499
Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu           
                175                 180                 185               

aaa aat gag atg gcg aga gca aac cat tat gag gac tat ggg gat tat       2547
Lys Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr           
            190                 195                 200                   

tgg aga gga gac tat gaa gta aat ggg gta gat ggc tat gac tac agc       2595
Trp Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser           
        205                 210                 215                       

cgc ggc cag ttg att gaa gat gtg gaa cat acc ttt gaa gag att aaa       2643
Arg Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys           
    220                 225                 230                           

cca tta tat gaa cat ctt cat gcc tat gtg agg gca aag ttg atg aat       2691
Pro Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn           
235                 240                 245                 250           

gcc tat cct tcc tat atc agt cca att gga tgc ctc cct gct cat ttg       2739
Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu           
                255                 260                 265               

ctt ggt gat atg tgg ggt aga ttt tgg aca aat ctg tac tct ttg aca       2787
Leu Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr           
            270                 275                 280                   

gtt ccc ttc gga cag aaa cca aac ata gat gtt act gat gca atg gtg       2835
Val Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val           
        285                 290                 295                       

gac cag gcc tgg gat gca cag aga ata ttc aag gag gcc gag aag ttc       2883
Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe           
    300                 305                 310                           

ttt gta tct gtt ggt ctt cct aat atg act caa gga ttc tgg gaa tat       2931
Phe Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr           
315                 320                 325                 330           

tcc atg cta acg gac cca gga aat gtt cag aaa gca gtc tgc ctt ccc       2979
Ser Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys Leu Pro           
                335                 340                 345               

aca gct tgg gac ctg ggg aag ggc gac ttc agg atc ctt atg tgc aca       3027
Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr           
            350                 355                 360                   

aag gtg aca atg gac gac ttc ctg aca gct cat cat gag atg ggg cat       3075
Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His           
        365                 370                 375                       

atc cag tat gat atg gca tat gct gca caa cct ttt ctg cta aga aat       3123
Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn           
    380                 385                 390                           

gga gct aat gaa gga ttc cat gaa gct gtt ggg gaa atc atg tca ctt       3171
Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu           
395                 400                 405                 410           

tct gca gcc aca cct aag cat tta aaa tcc att ggt ctt ctg tca ccc       3219
Ser Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro           
                415                 420                 425               

gat ttt caa gaa gac aat gaa aca gaa ata aac ttc ctg ctc aaa caa       3267
Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln           
            430                 435                 440                   

gca ctc acg att gtt ggg act ctg cca ttt act tac atg tta gag aag       3315
Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys           
        445                 450                 455                       

tgg agg tgg atg gtc ttt aaa ggg gaa att ccc aaa gac cag tgg atg       3363
Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met           
    460                 465                 470                           

aaa aag tgg tgg gag atg aag cga gag ata gtt ggg gtg gtg gaa cct       3411
Lys Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro           
475                 480                 485                 490           

gtg ccc cat gat gaa aca tac tgt gac ccc gca tct ctg ttc cat gtt       3459
Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val           
                495                 500                 505               

tct aat gat tac tca ttc att cga tat tac aca agg acc ctt tac caa       3507
Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln           
            510                 515                 520                   

ttc cag ttt caa gaa gca ctt tgt caa gca gct aaa cat gaa ggc cct       3555
Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro           
        525                 530                 535                       

ctg cac aaa tgt gac atc tca aac tct aca gaa gct gga cag aaa ctg       3603
Leu His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu           
    540                 545                 550                           

ttc aat atg ctg agg ctt gga aaa tca gaa ccc tgg acc cta gca ttg       3651
Phe Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu           
555                 560                 565                 570           

gaa aat gtt gta gga gca aag aac atg aat gta agg cca ctg ctc aac       3699
Glu Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn           
                575                 580                 585               

tac ttt gag ccc tta ttt acc tgg ctg aaa gac cag aac aag aat tct       3747
Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser           
            590                 595                 600                   

ttt gtg gga tgg agt acc gac tgg agt cca tat gca gac gag tct aag       3795
Phe Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys           
        605                 610                 615                       

tac ggc cct cct tgt cct tcc tgc ccc gct cct gaa ttt ctc ggc gga       3843
Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly           
    620                 625                 630                           

cct tcc gtg ttc ctg ttt cct cca aag cct aag gac acc ctg atg atc       3891
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
635                 640                 645                 650           

agc aga acc cct gaa gtg acc tgc gtg gtg gtg gac gtg tcc caa gag       3939
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu           
                655                 660                 665               

gat cct gag gtg cag ttc aat tgg tac gtc gac ggc gtg gaa gtg cac       3987
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
            670                 675                 680                   

aac gcc aag acc aag cct aga gag gaa cag ttc aac agc acc tac aga       4035
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg           
        685                 690                 695                       

gtg gtg tcc gtg ctg acc gtg ctg cac cag gat tgg ctg aac ggc aaa       4083
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys           
    700                 705                 710                           

gag tac aag tgc aag gtg tcc aac aag ggc ctg cca agc agc atc gag       4131
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu           
715                 720                 725                 730           

aaa acc atc agc aag gcc aag ggc cag cct agg gaa ccc cag gtt tac       4179
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
                735                 740                 745               

aca ctg cct cca agc caa gag gaa atg acc aag aac cag gtg tcc ctg       4227
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
            750                 755                 760                   

acc tgc ctg gtc aag ggc ttc tac cct tcc gat atc gcc gtg gaa tgg       4275
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
        765                 770                 775                       

gag agc aac ggc cag cct gag aac aac tac aag acc aca cct cct gtg       4323
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val           
    780                 785                 790                           

ctg gac agc gac ggc tca ttc ttc ctg tac tcc cgg ctg acc gtg gac       4371
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp           
795                 800                 805                 810           

aag tcc aga tgg caa gag ggc aac gtg ttc agc tgc agc gtg atg cac       4419
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His           
                815                 820                 825               

gag gcc ctg cac aat cac tac acc cag aag tcc ctg agt ctg agc ctg       4467
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu           
            830                 835                 840                   

ggc aag tgatgaggta cctctagagt cgacccgggc ggcctcgagg acggggtgaa        4523
Gly Lys                                                                   
                                                                          

ctacgcctga ggatccgatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc     4583

ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg     4643

gaattttttg tgtctctcac tcggaagcaa ttcgttgatc tgaatttcga ccacccataa     4703

tacccattac cctggtagat aagtagcatg gcgggttaat cattaactac aaggaacccc     4763

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     4823

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     4883

g                                                                     4884


<210>  20
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    610                 615                 620                 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            740                 745                 750         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        835                 840                 


<210>  21
<211>  4884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid comprising vector genome encoding hAce2(variant 
       3)-IgG4-FC


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE Enhancer

<220>
<221>  misc_feature
<222>  (198)..(863)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  Chicken beta actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1942)..(3786)
<223>  hAce2 (Varinat 3) (Gen3-3)

<220>
<221>  misc_feature
<222>  (1942)..(1992)
<223>  ACE2 signal peptide

<220>
<221>  CDS
<222>  (1942)..(4473)
<223>  hAce2 (variant 3) (Gen3-3) IgG4

<220>
<221>  misc_feature
<222>  (3787)..(4473)
<223>  human IgG4 FC

<220>
<221>  polyA_signal
<222>  (4540)..(4666)
<223>  Rabbit Globin poly A

<220>
<221>  repeat_region
<222>  (4755)..(4884)
<223>  3'ITR

<400>  21
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcccgccac c atg tca agc tct tcc tgg ctc ctt ctc agc       1971
                        Met Ser Ser Ser Ser Trp Leu Leu Leu Ser           
                        1               5                   10            

ctt gtt gct gta act gct gct cag tcc acc att gag gaa cag gcc aag       2019
Leu Val Ala Val Thr Ala Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys           
                15                  20                  25                

aca ttt ttg gac agg ttt aac cac gta gcc gaa gac ccg ttc tat caa       2067
Thr Phe Leu Asp Arg Phe Asn His Val Ala Glu Asp Pro Phe Tyr Gln           
            30                  35                  40                    

agt tca ctt gct tct tgg aat tat aac acc aat atc act gaa gag aat       2115
Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn           
        45                  50                  55                        

gcc caa aac atg aat aat gct ggg gac aaa tgg tct gcc ttt tta aag       2163
Ala Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys           
    60                  65                  70                            

gaa cag tcc aca ttt gcc caa atg tat cca cta caa gaa att cag gac       2211
Glu Gln Ser Thr Phe Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asp           
75                  80                  85                  90            

ctc aca gtc aag ctt cag ctg cag gct ctt cag caa aat ggg tct tca       2259
Leu Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser           
                95                  100                 105               

gtg ctc tca gaa gac aag agc aaa cgg ttg aac aca att cta aat aca       2307
Val Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr           
            110                 115                 120                   

atg agc acc atc tac agt act gga aaa gtt tgt aac ccg gat aat cca       2355
Met Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro           
        125                 130                 135                       

caa gaa tgc tta tta ctt gaa cca ggt ttg aat gaa ata atg gca aac       2403
Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn           
    140                 145                 150                           

agt tta gac tac aat gag agg ctc tgg gct tgg gaa agc tgg aga tct       2451
Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser           
155                 160                 165                 170           

gag gtc ggc aag cag ctg agg cca tta tat gaa gag tat gtg gtc ttg       2499
Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu           
                175                 180                 185               

aaa aat gag atg gcg aga gca aac cat tat gag gac tat ggg gat tat       2547
Lys Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr           
            190                 195                 200                   

tgg aga gga gac tat gaa gta aat ggg gta gat ggc tat gac tac agc       2595
Trp Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser           
        205                 210                 215                       

cgc ggc cag ttg att gaa gat gtg gaa cat acc ttt gaa gag att aaa       2643
Arg Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys           
    220                 225                 230                           

cca tta tat gaa cat ctt cat gcc tat gtg agg gca aag ttg atg aat       2691
Pro Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn           
235                 240                 245                 250           

gcc tat cct tcc tat atc agt cca att gga tgc ctc cct gct cat ttg       2739
Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu           
                255                 260                 265               

ctt ggt gat atg tgg ggt aga ttt tgg aca aat ctg tac tct ttg aca       2787
Leu Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr           
            270                 275                 280                   

gtt ccc ttc gga cag aaa cca aac ata gat gtt act gat gca atg gtg       2835
Val Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val           
        285                 290                 295                       

gac cag gcc tgg gat gca cag aga ata ttc aag gag gcc gag aag ttc       2883
Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe           
    300                 305                 310                           

ttt gta tct gtt ggt ctt cct aat atg act caa gga ttc tgg gaa tat       2931
Phe Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr           
315                 320                 325                 330           

tcc atg cta acg gac cca gga aat gtt cag aaa gca gtc tgc cat ccc       2979
Ser Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro           
                335                 340                 345               

aca gct tgg gac ctg ggg aag ggc gac ttc agg atc ctt atg tgc aca       3027
Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr           
            350                 355                 360                   

aag gtg aca atg gac gac ttc ctg aca gct cat cat gag atg ggg cat       3075
Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His           
        365                 370                 375                       

atc cag tat gat atg gca tat gct gca caa cct ttt ctg cta aga aat       3123
Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn           
    380                 385                 390                           

gga gct aat gaa gga ttc cat gaa gct gtt ggg gaa atc atg tca ctt       3171
Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu           
395                 400                 405                 410           

tct gca gcc aca cct aag cat tta aaa tcc att ggt ctt ctg tca ccc       3219
Ser Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro           
                415                 420                 425               

gat ttt caa gaa gac aat gaa aca gaa ata aac ttc ctg ctc aaa caa       3267
Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln           
            430                 435                 440                   

gca ctc acg att gtt ggg act ctg cca ttt act tac atg tta gag aag       3315
Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys           
        445                 450                 455                       

tgg agg tgg atg gtc ttt aaa ggg gaa att ccc aaa gac cag tgg atg       3363
Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met           
    460                 465                 470                           

aaa aag tgg tgg gag atg aag cga gag ata gtt ggg gtg gtg gaa cct       3411
Lys Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro           
475                 480                 485                 490           

gtg ccc cat gat gaa aca tac tgt gac ccc gca tct ctg ttc cat gtt       3459
Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val           
                495                 500                 505               

tct aat gat tac tca ttc att cga tat tac aca agg acc ctt tac caa       3507
Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln           
            510                 515                 520                   

ttc cag ttt caa gaa gca ctt tgt caa gca gct aaa cat gaa ggc cct       3555
Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro           
        525                 530                 535                       

ctg cac aaa tgt gac atc tca aac tct aca gaa gct gga cag aaa ctg       3603
Leu His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu           
    540                 545                 550                           

ttc aat atg ctg agg ctt gga aaa tca gaa ccc tgg acc cta gca ttg       3651
Phe Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu           
555                 560                 565                 570           

gaa aat gtt gta gga gca aag aac atg aat gta agg cca ctg ctc aac       3699
Glu Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn           
                575                 580                 585               

tac ttt gag ccc tta ttt acc tgg ctg aaa gac cag aac aag aat tct       3747
Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser           
            590                 595                 600                   

ttt gtg gga tgg agt acc gac tgg agt cca tat gca gac gag tct aag       3795
Phe Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys           
        605                 610                 615                       

tac ggc cct cct tgt cct tcc tgc ccc gct cct gaa ttt ctc ggc gga       3843
Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly           
    620                 625                 630                           

cct tcc gtg ttc ctg ttt cct cca aag cct aag gac acc ctg atg atc       3891
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
635                 640                 645                 650           

agc aga acc cct gaa gtg acc tgc gtg gtg gtg gac gtg tcc caa gag       3939
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu           
                655                 660                 665               

gat cct gag gtg cag ttc aat tgg tac gtc gac ggc gtg gaa gtg cac       3987
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
            670                 675                 680                   

aac gcc aag acc aag cct aga gag gaa cag ttc aac agc acc tac aga       4035
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg           
        685                 690                 695                       

gtg gtg tcc gtg ctg acc gtg ctg cac cag gat tgg ctg aac ggc aaa       4083
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys           
    700                 705                 710                           

gag tac aag tgc aag gtg tcc aac aag ggc ctg cca agc agc atc gag       4131
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu           
715                 720                 725                 730           

aaa acc atc agc aag gcc aag ggc cag cct agg gaa ccc cag gtt tac       4179
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
                735                 740                 745               

aca ctg cct cca agc caa gag gaa atg acc aag aac cag gtg tcc ctg       4227
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
            750                 755                 760                   

acc tgc ctg gtc aag ggc ttc tac cct tcc gat atc gcc gtg gaa tgg       4275
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
        765                 770                 775                       

gag agc aac ggc cag cct gag aac aac tac aag acc aca cct cct gtg       4323
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val           
    780                 785                 790                           

ctg gac agc gac ggc tca ttc ttc ctg tac tcc cgg ctg acc gtg gac       4371
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp           
795                 800                 805                 810           

aag tcc aga tgg caa gag ggc aac gtg ttc agc tgc agc gtg atg cac       4419
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His           
                815                 820                 825               

gag gcc ctg cac aat cac tac acc cag aag tcc ctg agt ctg agc ctg       4467
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu           
            830                 835                 840                   

ggc aag tgatgaggta cctctagagt cgacccgggc ggcctcgagg acggggtgaa        4523
Gly Lys                                                                   
                                                                          

ctacgcctga ggatccgatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc     4583

ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg     4643

gaattttttg tgtctctcac tcggaagcaa ttcgttgatc tgaatttcga ccacccataa     4703

tacccattac cctggtagat aagtagcatg gcgggttaat cattaactac aaggaacccc     4763

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     4823

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     4883

g                                                                     4884


<210>  22
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Arg Phe 
            20                  25                  30          


Asn His Val Ala Glu Asp Pro Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Ala Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    610                 615                 620                 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            740                 745                 750         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        835                 840                 


<210>  23
<211>  4884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid comprising vector genome encoding hAce2(variant 
       4)-IgG4-FC


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE Enhancer

<220>
<221>  misc_feature
<222>  (198)..(863)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  Chicken beta actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1942)..(3786)
<223>  hAce2 (variant 4) (GTP14-Gen3-5)

<220>
<221>  misc_feature
<222>  (1942)..(1992)
<223>  ACE2 signal peptide

<220>
<221>  CDS
<222>  (1942)..(4473)
<223>  hAce2(varinat 4) (GTP14 Gen3-5) IgG4

<220>
<221>  misc_feature
<222>  (3787)..(4473)
<223>  Human IgG4 Fc

<220>
<221>  polyA_signal
<222>  (4540)..(4666)
<223>  Rabbit globin polyA

<220>
<221>  repeat_region
<222>  (4755)..(4884)
<223>  3'ITR

<400>  23
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcccgccac c atg tca agc tct tcc tgg ctc ctt ctc agc       1971
                        Met Ser Ser Ser Ser Trp Leu Leu Leu Ser           
                        1               5                   10            

ctt gtt gct gta act gct gct cag tcc acc att gag gaa cag gcc aag       2019
Leu Val Ala Val Thr Ala Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys           
                15                  20                  25                

aca ttt ttg gac atg ttt aac cac aaa gcc gaa gac ctg ttc tat caa       2067
Thr Phe Leu Asp Met Phe Asn His Lys Ala Glu Asp Leu Phe Tyr Gln           
            30                  35                  40                    

agt tca ctt gct tct tgg aat tat aac acc aat att act gaa gag aat       2115
Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn           
        45                  50                  55                        

gtc caa aac atg aat aat gct ggg gac aaa tgg tct gcc ttt tta aag       2163
Val Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys           
    60                  65                  70                            

gaa cag tcc aca att gcc caa atg tat cca cta caa gaa att cag aat       2211
Glu Gln Ser Thr Ile Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn           
75                  80                  85                  90            

ccc aca gtc aag ctt cag ctg cag gct ctt cag caa aat ggg tct tca       2259
Pro Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser           
                95                  100                 105               

gtg ctc tca gaa gac aag agc aaa cgg ttg aac aca att cta aat aca       2307
Val Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr           
            110                 115                 120                   

atg agc acc atc tac agt act gga aaa gtt tgt aac ccg gat aat cca       2355
Met Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro           
        125                 130                 135                       

caa gaa tgc tta tta ctt gaa cca ggt ttg aat gaa ata atg gca aac       2403
Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn           
    140                 145                 150                           

agt tta gac tac aat gag agg ctc tgg gct tgg gaa agc tgg aga tct       2451
Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser           
155                 160                 165                 170           

gag gtc ggc aag cag ctg agg cca tta tat gaa gag tat gtg gtc ttg       2499
Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu           
                175                 180                 185               

aaa aat gag atg gcg aga gca aac cat tat gag gac tat ggg gat tat       2547
Lys Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr           
            190                 195                 200                   

tgg aga gga gac tat gaa gta aat ggg gta gat ggc tat gac tac agc       2595
Trp Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser           
        205                 210                 215                       

cgc ggc cag ttg att gaa gat gtg gaa cat acc ttt gaa gag att aaa       2643
Arg Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys           
    220                 225                 230                           

cca tta tat gaa cat ctt cat gcc tat gtg agg gca aag ttg atg aat       2691
Pro Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn           
235                 240                 245                 250           

gcc tat cct tcc tat atc agt cca att gga tgc ctc cct gct cat ttg       2739
Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu           
                255                 260                 265               

ctt ggt gat atg tgg ggt aga ttt tgg aca aat ctg tac tct ttg aca       2787
Leu Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr           
            270                 275                 280                   

gtt ccc ttc gga cag aaa cca aac ata gat gtt act gat gca atg gtg       2835
Val Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val           
        285                 290                 295                       

gac cag gcc tgg gat gca cag aga ata ttc aag gag gcc gag aag ttc       2883
Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe           
    300                 305                 310                           

ttt gta tct gtt ggt ctt cct aat atg act caa gga ttc tgg gaa tat       2931
Phe Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr           
315                 320                 325                 330           

tcc atg cta acg gac cca gga aat gtt cag aaa gca gtc tgc cat ccc       2979
Ser Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro           
                335                 340                 345               

aca gct tgg gac ctg ggg aag ggc gac ttc agg atc ctt atg tgc aca       3027
Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr           
            350                 355                 360                   

aag gtg aca atg gac gac ttc ctg aca gct cat cat gag atg ggg cat       3075
Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His           
        365                 370                 375                       

atc cag tat gat atg gca tat gct gca caa cct ttt ctg cta aga aat       3123
Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn           
    380                 385                 390                           

gga gct aat gaa gga ttc cat gaa gct gtt ggg gaa atc atg tca ctt       3171
Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu           
395                 400                 405                 410           

tct gca gcc aca cct aag cat tta aaa tcc att ggt ctt ctg tca ccc       3219
Ser Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro           
                415                 420                 425               

gat ttt caa gaa gac aat gaa aca gaa ata aac ttc ctg ctc aaa caa       3267
Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln           
            430                 435                 440                   

gca ctc acg att gtt ggg act ctg cca ttt act tac atg tta gag aag       3315
Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys           
        445                 450                 455                       

tgg agg tgg atg gtc ttt aaa ggg gaa att ccc aaa gac cag tgg atg       3363
Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met           
    460                 465                 470                           

aaa aag tgg tgg gag atg aag cga gag ata gtt ggg gtg gtg gaa cct       3411
Lys Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro           
475                 480                 485                 490           

gtg ccc cat gat gaa aca tac tgt gac ccc gca tct ctg ttc cat gtt       3459
Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val           
                495                 500                 505               

tct aat gat tac tca ttc att cga tat tac aca agg acc ctt tac caa       3507
Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln           
            510                 515                 520                   

ttc cag ttt caa gaa gca ctt tgt caa gca gct aaa cat gaa ggc cct       3555
Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro           
        525                 530                 535                       

ctg cac aaa tgt gac atc tca aac tct aca gaa gct gga cag aaa ctg       3603
Leu His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu           
    540                 545                 550                           

ttc aat atg ctg agg ctt gga aaa tca gaa ccc tgg acc cta gca ttg       3651
Phe Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu           
555                 560                 565                 570           

gaa aat gtt gta gga gca aag aac atg aat gta agg cca ctg ctc aac       3699
Glu Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn           
                575                 580                 585               

tac ttt gag ccc tta ttt acc tgg ctg aaa gac cag aac aag aat tct       3747
Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser           
            590                 595                 600                   

ttt gtg gga tgg agt acc gac tgg agt cca tat gca gac gag tct aag       3795
Phe Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys           
        605                 610                 615                       

tac ggc cct cct tgt cct tcc tgc ccc gct cct gaa ttt ctc ggc gga       3843
Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly           
    620                 625                 630                           

cct tcc gtg ttc ctg ttt cct cca aag cct aag gac acc ctg atg atc       3891
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
635                 640                 645                 650           

agc aga acc cct gaa gtg acc tgc gtg gtg gtg gac gtg tcc caa gag       3939
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu           
                655                 660                 665               

gat cct gag gtg cag ttc aat tgg tac gtc gac ggc gtg gaa gtg cac       3987
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
            670                 675                 680                   

aac gcc aag acc aag cct aga gag gaa cag ttc aac agc acc tac aga       4035
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg           
        685                 690                 695                       

gtg gtg tcc gtg ctg acc gtg ctg cac cag gat tgg ctg aac ggc aaa       4083
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys           
    700                 705                 710                           

gag tac aag tgc aag gtg tcc aac aag ggc ctg cca agc agc atc gag       4131
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu           
715                 720                 725                 730           

aaa acc atc agc aag gcc aag ggc cag cct agg gaa ccc cag gtt tac       4179
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
                735                 740                 745               

aca ctg cct cca agc caa gag gaa atg acc aag aac cag gtg tcc ctg       4227
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
            750                 755                 760                   

acc tgc ctg gtc aag ggc ttc tac cct tcc gat atc gcc gtg gaa tgg       4275
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
        765                 770                 775                       

gag agc aac ggc cag cct gag aac aac tac aag acc aca cct cct gtg       4323
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val           
    780                 785                 790                           

ctg gac agc gac ggc tca ttc ttc ctg tac tcc cgg ctg acc gtg gac       4371
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp           
795                 800                 805                 810           

aag tcc aga tgg caa gag ggc aac gtg ttc agc tgc agc gtg atg cac       4419
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His           
                815                 820                 825               

gag gcc ctg cac aat cac tac acc cag aag tcc ctg agt ctg agc ctg       4467
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu           
            830                 835                 840                   

ggc aag tgatgaggta cctctagagt cgacccgggc ggcctcgagg acggggtgaa        4523
Gly Lys                                                                   
                                                                          

ctacgcctga ggatccgatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc     4583

ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg     4643

gaattttttg tgtctctcac tcggaagcaa ttcgttgatc tgaatttcga ccacccataa     4703

tacccattac cctggtagat aagtagcatg gcgggttaat cattaactac aaggaacccc     4763

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     4823

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     4883

g                                                                     4884


<210>  24
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Ile Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    610                 615                 620                 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            740                 745                 750         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        835                 840                 


<210>  25
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 isoform 1 amino acid sequence NP_068576.1

<400>  25

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  26
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 1 nucleic acid sequence without signal/leader 
       peptide

<400>  26
cagtccacca ttgaggaaca ggccaagaca tttttggaca tgtttaacca caaagccgaa       60

gacctgttct atcaaagttc acttgctgct tggaattata acaccaatat tactgaagag      120

aatgtccaaa acatgaataa cgctggggac aaatggtctg cctttttaaa ggaacagtcc      180

acatttgccc aaatgtatcc actacaagaa attcagaatc ccacagtcaa gcttcagctg      240

caggctcttc agcaaaatgg gtcttcagtg ctctcagaag acaagagcaa acggttgaac      300

acaattctaa atacaatgag caccatctac agtactggaa aagtttgtaa cccggataat      360

ccacaagaat gcttattact tgaaccaggt ttgaatgaaa taatggcaaa cagtttagac      420

tacaatgaga ggctctgggc ttgggaaagc tggagatctg aggtcggcaa gcagctgagg      480

ccattatatg aagagtatgt ggtcttgaaa aatgagatgg cgagagcaaa ccattatgag      540

gactatgggg attattggag aggagactat gaagtaaatg gggtagatgg ctatgactac      600

agccgcggcc agttgattga agatgtggaa catacctttg aagagattaa accattatat      660

gaacatcttc atgcctatgt gagggcaaag ttgatgaatg cctatccttc ctatatcagt      720

ccaattggat gcctccctgc tcatttgctt ggtgatatgt ggggtagatt ttggacaaat      780

ctgtactctt tgacagttcc cttcggacag aaaccaaaca tagatgttac tgatgcaatg      840

gtggaccagg cctgggatgc acagagaata ttcaaggagg ccgagaagtt ctttgtatct      900

gttggtcttc ctaatatgac tcaaggattc tgggaatatt ccatgctaac ggacccagga      960

aatgttcaga aagcagtctg ccatcccaca gcttgggacc tggggaaggg cgacttcagg     1020

atccttatgt gcacaaaggt gacaatggac gacttcctga cagctcatca tgagatgggg     1080

catatccagt atgatatggc atatgctgca caaccttttc tgctaagaaa tggagctaat     1140

gaaggattcc atgaagctgt tggggaaatc atgtcacttt ctgcagccac acctaagcat     1200

ttaaaatcca ttggtcttct gtcacccgat tttcaagaag acaatgaaac agaaataaac     1260

ttcctgctca aacaagcact cacgattgtt gggactctgc catttactta catgttagag     1320

aagtggaggt ggatggtctt taaaggggaa attcccaaag accagtggat gaaaaagtgg     1380

tgggagatga agcgagagat agttggggtg gtggaacctg tgccccatga tgaaacatac     1440

tgtgaccccg catctctgtt ccatgtttct aatgattact cattcattcg atattacaca     1500

aggacccttt accaattcca gtttcaagaa gcactttgtc aagcagctaa acatgaaggc     1560

cctctgcaca aatgtgacat ctcaaactct acagaagctg gacagaaact gttcaatatg     1620

ctgaggcttg gaaaatcaga accctggacc ctagcattgg aaaatgttgt aggagcaaag     1680

aacatgaatg taaggccact gctcaactac tttgagccct tatttacctg gctgaaagac     1740

cagaacaaga attcttttgt gggatggagt accgactgga gtccatatgc agac           1794


<210>  27
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 1 amino acid sequence without signal/leader peptide

<400>  27

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  28
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 2 nucleic acid sequence without signal/leader 
       peptide

<400>  28
cagtccacca ttgaggaaca ggccaagaca tttttggaca tgtttaacca caaagccgaa       60

gacctgttct atcaaagttc acttgctgct tggaattata acaccaatat tactgaagag      120

aatgtccaaa acatgaataa cgctggggac aaatggtctg cctttttaaa ggaacagtcc      180

acatttgccc aaatgtatcc actacaagaa attcagaatc ccacagtcaa gcttcagctg      240

caggctcttc agcaaaatgg gtcttcagtg ctctcagaag acaagagcaa acggttgaac      300

acaattctaa atacaatgag caccatctac agtactggaa aagtttgtaa cccggataat      360

ccacaagaat gcttattact tgaaccaggt ttgaatgaaa taatggcaaa cagtttagac      420

tacaatgaga ggctctgggc ttgggaaagc tggagatctg aggtcggcaa gcagctgagg      480

ccattatatg aagagtatgt ggtcttgaaa aatgagatgg cgagagcaaa ccattatgag      540

gactatgggg attattggag aggagactat gaagtaaatg gggtagatgg ctatgactac      600

agccgcggcc agttgattga agatgtggaa catacctttg aagagattaa accattatat      660

gaacatcttc atgcctatgt gagggcaaag ttgatgaatg cctatccttc ctatatcagt      720

ccaattggat gcctccctgc tcatttgctt ggtgatatgt ggggtagatt ttggacaaat      780

ctgtactctt tgacagttcc cttcggacag aaaccaaaca tagatgttac tgatgcaatg      840

gtggaccagg cctgggatgc acagagaata ttcaaggagg ccgagaagtt ctttgtatct      900

gttggtcttc ctaatatgac tcaaggattc tgggaatatt ccatgctaac ggacccagga      960

aatgttcaga aagcagtctg ccttcccaca gcttgggacc tggggaaggg cgacttcagg     1020

atccttatgt gcacaaaggt gacaatggac gacttcctga cagctcatca tgagatgggg     1080

catatccagt atgatatggc atatgctgca caaccttttc tgctaagaaa tggagctaat     1140

gaaggattcc atgaagctgt tggggaaatc atgtcacttt ctgcagccac acctaagcat     1200

ttaaaatcca ttggtcttct gtcacccgat tttcaagaag acaatgaaac agaaataaac     1260

ttcctgctca aacaagcact cacgattgtt gggactctgc catttactta catgttagag     1320

aagtggaggt ggatggtctt taaaggggaa attcccaaag accagtggat gaaaaagtgg     1380

tgggagatga agcgagagat agttggggtg gtggaacctg tgccccatga tgaaacatac     1440

tgtgaccccg catctctgtt ccatgtttct aatgattact cattcattcg atattacaca     1500

aggacccttt accaattcca gtttcaagaa gcactttgtc aagcagctaa acatgaaggc     1560

cctctgcaca aatgtgacat ctcaaactct acagaagctg gacagaaact gttcaatatg     1620

ctgaggcttg gaaaatcaga accctggacc ctagcattgg aaaatgttgt aggagcaaag     1680

aacatgaatg taaggccact gctcaactac tttgagccct tatttacctg gctgaaagac     1740

cagaacaaga attcttttgt gggatggagt accgactgga gtccatatgc agac           1794


<210>  29
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 2 amino acid sequence without signal/leader peptide

<400>  29

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  30
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 3 nucleic acid sequence without signal/leader 
       sequence

<400>  30
cagtccacca ttgaggaaca ggccaagaca tttttggaca ggtttaacca cgtagccgaa       60

gacccgttct atcaaagttc acttgcttct tggaattata acaccaatat cactgaagag      120

aatgcccaaa acatgaataa tgctggggac aaatggtctg cctttttaaa ggaacagtcc      180

acatttgccc aaatgtatcc actacaagaa attcaggacc tcacagtcaa gcttcagctg      240

caggctcttc agcaaaatgg gtcttcagtg ctctcagaag acaagagcaa acggttgaac      300

acaattctaa atacaatgag caccatctac agtactggaa aagtttgtaa cccggataat      360

ccacaagaat gcttattact tgaaccaggt ttgaatgaaa taatggcaaa cagtttagac      420

tacaatgaga ggctctgggc ttgggaaagc tggagatctg aggtcggcaa gcagctgagg      480

ccattatatg aagagtatgt ggtcttgaaa aatgagatgg cgagagcaaa ccattatgag      540

gactatgggg attattggag aggagactat gaagtaaatg gggtagatgg ctatgactac      600

agccgcggcc agttgattga agatgtggaa catacctttg aagagattaa accattatat      660

gaacatcttc atgcctatgt gagggcaaag ttgatgaatg cctatccttc ctatatcagt      720

ccaattggat gcctccctgc tcatttgctt ggtgatatgt ggggtagatt ttggacaaat      780

ctgtactctt tgacagttcc cttcggacag aaaccaaaca tagatgttac tgatgcaatg      840

gtggaccagg cctgggatgc acagagaata ttcaaggagg ccgagaagtt ctttgtatct      900

gttggtcttc ctaatatgac tcaaggattc tgggaatatt ccatgctaac ggacccagga      960

aatgttcaga aagcagtctg ccatcccaca gcttgggacc tggggaaggg cgacttcagg     1020

atccttatgt gcacaaaggt gacaatggac gacttcctga cagctcatca tgagatgggg     1080

catatccagt atgatatggc atatgctgca caaccttttc tgctaagaaa tggagctaat     1140

gaaggattcc atgaagctgt tggggaaatc atgtcacttt ctgcagccac acctaagcat     1200

ttaaaatcca ttggtcttct gtcacccgat tttcaagaag acaatgaaac agaaataaac     1260

ttcctgctca aacaagcact cacgattgtt gggactctgc catttactta catgttagag     1320

aagtggaggt ggatggtctt taaaggggaa attcccaaag accagtggat gaaaaagtgg     1380

tgggagatga agcgagagat agttggggtg gtggaacctg tgccccatga tgaaacatac     1440

tgtgaccccg catctctgtt ccatgtttct aatgattact cattcattcg atattacaca     1500

aggacccttt accaattcca gtttcaagaa gcactttgtc aagcagctaa acatgaaggc     1560

cctctgcaca aatgtgacat ctcaaactct acagaagctg gacagaaact gttcaatatg     1620

ctgaggcttg gaaaatcaga accctggacc ctagcattgg aaaatgttgt aggagcaaag     1680

aacatgaatg taaggccact gctcaactac tttgagccct tatttacctg gctgaaagac     1740

cagaacaaga attcttttgt gggatggagt accgactgga gtccatatgc agac           1794


<210>  31
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 3 amino acid sequence without signal/leader 
       sequence

<400>  31

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Arg Phe Asn 
1               5                   10                  15      


His Val Ala Glu Asp Pro Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Ala Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  32
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 4 nucleic acid sequence without signal/leader 
       peptide

<400>  32
cagtccacca ttgaggaaca ggccaagaca tttttggaca tgtttaacca caaagccgaa       60

gacctgttct atcaaagttc acttgcttct tggaattata acaccaatat tactgaagag      120

aatgtccaaa acatgaataa tgctggggac aaatggtctg cctttttaaa ggaacagtcc      180

acaattgccc aaatgtatcc actacaagaa attcagaatc ccacagtcaa gcttcagctg      240

caggctcttc agcaaaatgg gtcttcagtg ctctcagaag acaagagcaa acggttgaac      300

acaattctaa atacaatgag caccatctac agtactggaa aagtttgtaa cccggataat      360

ccacaagaat gcttattact tgaaccaggt ttgaatgaaa taatggcaaa cagtttagac      420

tacaatgaga ggctctgggc ttgggaaagc tggagatctg aggtcggcaa gcagctgagg      480

ccattatatg aagagtatgt ggtcttgaaa aatgagatgg cgagagcaaa ccattatgag      540

gactatgggg attattggag aggagactat gaagtaaatg gggtagatgg ctatgactac      600

agccgcggcc agttgattga agatgtggaa catacctttg aagagattaa accattatat      660

gaacatcttc atgcctatgt gagggcaaag ttgatgaatg cctatccttc ctatatcagt      720

ccaattggat gcctccctgc tcatttgctt ggtgatatgt ggggtagatt ttggacaaat      780

ctgtactctt tgacagttcc cttcggacag aaaccaaaca tagatgttac tgatgcaatg      840

gtggaccagg cctgggatgc acagagaata ttcaaggagg ccgagaagtt ctttgtatct      900

gttggtcttc ctaatatgac tcaaggattc tgggaatatt ccatgctaac ggacccagga      960

aatgttcaga aagcagtctg ccatcccaca gcttgggacc tggggaaggg cgacttcagg     1020

atccttatgt gcacaaaggt gacaatggac gacttcctga cagctcatca tgagatgggg     1080

catatccagt atgatatggc atatgctgca caaccttttc tgctaagaaa tggagctaat     1140

gaaggattcc atgaagctgt tggggaaatc atgtcacttt ctgcagccac acctaagcat     1200

ttaaaatcca ttggtcttct gtcacccgat tttcaagaag acaatgaaac agaaataaac     1260

ttcctgctca aacaagcact cacgattgtt gggactctgc catttactta catgttagag     1320

aagtggaggt ggatggtctt taaaggggaa attcccaaag accagtggat gaaaaagtgg     1380

tgggagatga agcgagagat agttggggtg gtggaacctg tgccccatga tgaaacatac     1440

tgtgaccccg catctctgtt ccatgtttct aatgattact cattcattcg atattacaca     1500

aggacccttt accaattcca gtttcaagaa gcactttgtc aagcagctaa acatgaaggc     1560

cctctgcaca aatgtgacat ctcaaactct acagaagctg gacagaaact gttcaatatg     1620

ctgaggcttg gaaaatcaga accctggacc ctagcattgg aaaatgttgt aggagcaaag     1680

aacatgaatg taaggccact gctcaactac tttgagccct tatttacctg gctgaaagac     1740

cagaacaaga attcttttgt gggatggagt accgactgga gtccatatgc agac           1794


<210>  33
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 4 amino acid sequence without signal/leader peptide

<400>  33

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Ile Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  34
<211>  2484
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-variant1-IgG4 nucleic acid sequence without signal/leader 
       peptide

<400>  34
cagtccacca ttgaggaaca ggccaagaca tttttggaca tgtttaacca caaagccgaa       60

gacctgttct atcaaagttc acttgctgct tggaattata acaccaatat tactgaagag      120

aatgtccaaa acatgaataa cgctggggac aaatggtctg cctttttaaa ggaacagtcc      180

acatttgccc aaatgtatcc actacaagaa attcagaatc ccacagtcaa gcttcagctg      240

caggctcttc agcaaaatgg gtcttcagtg ctctcagaag acaagagcaa acggttgaac      300

acaattctaa atacaatgag caccatctac agtactggaa aagtttgtaa cccggataat      360

ccacaagaat gcttattact tgaaccaggt ttgaatgaaa taatggcaaa cagtttagac      420

tacaatgaga ggctctgggc ttgggaaagc tggagatctg aggtcggcaa gcagctgagg      480

ccattatatg aagagtatgt ggtcttgaaa aatgagatgg cgagagcaaa ccattatgag      540

gactatgggg attattggag aggagactat gaagtaaatg gggtagatgg ctatgactac      600

agccgcggcc agttgattga agatgtggaa catacctttg aagagattaa accattatat      660

gaacatcttc atgcctatgt gagggcaaag ttgatgaatg cctatccttc ctatatcagt      720

ccaattggat gcctccctgc tcatttgctt ggtgatatgt ggggtagatt ttggacaaat      780

ctgtactctt tgacagttcc cttcggacag aaaccaaaca tagatgttac tgatgcaatg      840

gtggaccagg cctgggatgc acagagaata ttcaaggagg ccgagaagtt ctttgtatct      900

gttggtcttc ctaatatgac tcaaggattc tgggaatatt ccatgctaac ggacccagga      960

aatgttcaga aagcagtctg ccatcccaca gcttgggacc tggggaaggg cgacttcagg     1020

atccttatgt gcacaaaggt gacaatggac gacttcctga cagctcatca tgagatgggg     1080

catatccagt atgatatggc atatgctgca caaccttttc tgctaagaaa tggagctaat     1140

gaaggattcc atgaagctgt tggggaaatc atgtcacttt ctgcagccac acctaagcat     1200

ttaaaatcca ttggtcttct gtcacccgat tttcaagaag acaatgaaac agaaataaac     1260

ttcctgctca aacaagcact cacgattgtt gggactctgc catttactta catgttagag     1320

aagtggaggt ggatggtctt taaaggggaa attcccaaag accagtggat gaaaaagtgg     1380

tgggagatga agcgagagat agttggggtg gtggaacctg tgccccatga tgaaacatac     1440

tgtgaccccg catctctgtt ccatgtttct aatgattact cattcattcg atattacaca     1500

aggacccttt accaattcca gtttcaagaa gcactttgtc aagcagctaa acatgaaggc     1560

cctctgcaca aatgtgacat ctcaaactct acagaagctg gacagaaact gttcaatatg     1620

ctgaggcttg gaaaatcaga accctggacc ctagcattgg aaaatgttgt aggagcaaag     1680

aacatgaatg taaggccact gctcaactac tttgagccct tatttacctg gctgaaagac     1740

cagaacaaga attcttttgt gggatggagt accgactgga gtccatatgc agacgagtct     1800

aagtacggcc ctccttgtcc ttcctgcccc gctcctgaat ttctcggcgg accttccgtg     1860

ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc     1920

tgcgtggtgg tggacgtgtc ccaagaggat cctgaggtgc agttcaattg gtacgtcgac     1980

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa cagcacctac     2040

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag     2100

tgcaaggtgt ccaacaaggg cctgccaagc agcatcgaga aaaccatcag caaggccaag     2160

ggccagccta gggaacccca ggtttacaca ctgcctccaa gccaagagga aatgaccaag     2220

aaccaggtgt ccctgacctg cctggtcaag ggcttctacc cttccgatat cgccgtggaa     2280

tgggagagca acggccagcc tgagaacaac tacaagacca cacctcctgt gctggacagc     2340

gacggctcat tcttcctgta ctcccggctg accgtggaca agtccagatg gcaagagggc     2400

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     2460

ctgagtctga gcctgggcaa gtga                                            2484


<210>  35
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2-variant1-IgG4amino acid sequence without signal/leader 
       peptide

<400>  35

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
        595                 600                 605             


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    610                 615                 620                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
625                 630                 635                 640 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                645                 650                 655     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            660                 665                 670         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        675                 680                 685             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    690                 695                 700                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
705                 710                 715                 720 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                725                 730                 735     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            740                 745                 750         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        755                 760                 765             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    770                 775                 780                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
785                 790                 795                 800 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                805                 810                 815     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            820                 825         


<210>  36
<211>  2484
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-variant2-IgG4 nucleic acid sequence without signal/leader 
       peptide

<400>  36
cagtccacca ttgaggaaca ggccaagaca tttttggaca tgtttaacca caaagccgaa       60

gacctgttct atcaaagttc acttgctgct tggaattata acaccaatat tactgaagag      120

aatgtccaaa acatgaataa cgctggggac aaatggtctg cctttttaaa ggaacagtcc      180

acatttgccc aaatgtatcc actacaagaa attcagaatc ccacagtcaa gcttcagctg      240

caggctcttc agcaaaatgg gtcttcagtg ctctcagaag acaagagcaa acggttgaac      300

acaattctaa atacaatgag caccatctac agtactggaa aagtttgtaa cccggataat      360

ccacaagaat gcttattact tgaaccaggt ttgaatgaaa taatggcaaa cagtttagac      420

tacaatgaga ggctctgggc ttgggaaagc tggagatctg aggtcggcaa gcagctgagg      480

ccattatatg aagagtatgt ggtcttgaaa aatgagatgg cgagagcaaa ccattatgag      540

gactatgggg attattggag aggagactat gaagtaaatg gggtagatgg ctatgactac      600

agccgcggcc agttgattga agatgtggaa catacctttg aagagattaa accattatat      660

gaacatcttc atgcctatgt gagggcaaag ttgatgaatg cctatccttc ctatatcagt      720

ccaattggat gcctccctgc tcatttgctt ggtgatatgt ggggtagatt ttggacaaat      780

ctgtactctt tgacagttcc cttcggacag aaaccaaaca tagatgttac tgatgcaatg      840

gtggaccagg cctgggatgc acagagaata ttcaaggagg ccgagaagtt ctttgtatct      900

gttggtcttc ctaatatgac tcaaggattc tgggaatatt ccatgctaac ggacccagga      960

aatgttcaga aagcagtctg ccttcccaca gcttgggacc tggggaaggg cgacttcagg     1020

atccttatgt gcacaaaggt gacaatggac gacttcctga cagctcatca tgagatgggg     1080

catatccagt atgatatggc atatgctgca caaccttttc tgctaagaaa tggagctaat     1140

gaaggattcc atgaagctgt tggggaaatc atgtcacttt ctgcagccac acctaagcat     1200

ttaaaatcca ttggtcttct gtcacccgat tttcaagaag acaatgaaac agaaataaac     1260

ttcctgctca aacaagcact cacgattgtt gggactctgc catttactta catgttagag     1320

aagtggaggt ggatggtctt taaaggggaa attcccaaag accagtggat gaaaaagtgg     1380

tgggagatga agcgagagat agttggggtg gtggaacctg tgccccatga tgaaacatac     1440

tgtgaccccg catctctgtt ccatgtttct aatgattact cattcattcg atattacaca     1500

aggacccttt accaattcca gtttcaagaa gcactttgtc aagcagctaa acatgaaggc     1560

cctctgcaca aatgtgacat ctcaaactct acagaagctg gacagaaact gttcaatatg     1620

ctgaggcttg gaaaatcaga accctggacc ctagcattgg aaaatgttgt aggagcaaag     1680

aacatgaatg taaggccact gctcaactac tttgagccct tatttacctg gctgaaagac     1740

cagaacaaga attcttttgt gggatggagt accgactgga gtccatatgc agacgagtct     1800

aagtacggcc ctccttgtcc ttcctgcccc gctcctgaat ttctcggcgg accttccgtg     1860

ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc     1920

tgcgtggtgg tggacgtgtc ccaagaggat cctgaggtgc agttcaattg gtacgtcgac     1980

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa cagcacctac     2040

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag     2100

tgcaaggtgt ccaacaaggg cctgccaagc agcatcgaga aaaccatcag caaggccaag     2160

ggccagccta gggaacccca ggtttacaca ctgcctccaa gccaagagga aatgaccaag     2220

aaccaggtgt ccctgacctg cctggtcaag ggcttctacc cttccgatat cgccgtggaa     2280

tgggagagca acggccagcc tgagaacaac tacaagacca cacctcctgt gctggacagc     2340

gacggctcat tcttcctgta ctcccggctg accgtggaca agtccagatg gcaagagggc     2400

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     2460

ctgagtctga gcctgggcaa gtga                                            2484


<210>  37
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2-variant2-IgG4amino acid sequence without signal/leader 
       peptide

<400>  37

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
        595                 600                 605             


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    610                 615                 620                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
625                 630                 635                 640 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                645                 650                 655     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            660                 665                 670         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        675                 680                 685             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    690                 695                 700                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
705                 710                 715                 720 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                725                 730                 735     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            740                 745                 750         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        755                 760                 765             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    770                 775                 780                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
785                 790                 795                 800 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                805                 810                 815     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            820                 825         


<210>  38
<211>  2484
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-variant3-IgG4 nucleic acid sequence without signal/leader 
       peptide

<400>  38
cagtccacca ttgaggaaca ggccaagaca tttttggaca ggtttaacca cgtagccgaa       60

gacccgttct atcaaagttc acttgcttct tggaattata acaccaatat cactgaagag      120

aatgcccaaa acatgaataa tgctggggac aaatggtctg cctttttaaa ggaacagtcc      180

acatttgccc aaatgtatcc actacaagaa attcaggacc tcacagtcaa gcttcagctg      240

caggctcttc agcaaaatgg gtcttcagtg ctctcagaag acaagagcaa acggttgaac      300

acaattctaa atacaatgag caccatctac agtactggaa aagtttgtaa cccggataat      360

ccacaagaat gcttattact tgaaccaggt ttgaatgaaa taatggcaaa cagtttagac      420

tacaatgaga ggctctgggc ttgggaaagc tggagatctg aggtcggcaa gcagctgagg      480

ccattatatg aagagtatgt ggtcttgaaa aatgagatgg cgagagcaaa ccattatgag      540

gactatgggg attattggag aggagactat gaagtaaatg gggtagatgg ctatgactac      600

agccgcggcc agttgattga agatgtggaa catacctttg aagagattaa accattatat      660

gaacatcttc atgcctatgt gagggcaaag ttgatgaatg cctatccttc ctatatcagt      720

ccaattggat gcctccctgc tcatttgctt ggtgatatgt ggggtagatt ttggacaaat      780

ctgtactctt tgacagttcc cttcggacag aaaccaaaca tagatgttac tgatgcaatg      840

gtggaccagg cctgggatgc acagagaata ttcaaggagg ccgagaagtt ctttgtatct      900

gttggtcttc ctaatatgac tcaaggattc tgggaatatt ccatgctaac ggacccagga      960

aatgttcaga aagcagtctg ccatcccaca gcttgggacc tggggaaggg cgacttcagg     1020

atccttatgt gcacaaaggt gacaatggac gacttcctga cagctcatca tgagatgggg     1080

catatccagt atgatatggc atatgctgca caaccttttc tgctaagaaa tggagctaat     1140

gaaggattcc atgaagctgt tggggaaatc atgtcacttt ctgcagccac acctaagcat     1200

ttaaaatcca ttggtcttct gtcacccgat tttcaagaag acaatgaaac agaaataaac     1260

ttcctgctca aacaagcact cacgattgtt gggactctgc catttactta catgttagag     1320

aagtggaggt ggatggtctt taaaggggaa attcccaaag accagtggat gaaaaagtgg     1380

tgggagatga agcgagagat agttggggtg gtggaacctg tgccccatga tgaaacatac     1440

tgtgaccccg catctctgtt ccatgtttct aatgattact cattcattcg atattacaca     1500

aggacccttt accaattcca gtttcaagaa gcactttgtc aagcagctaa acatgaaggc     1560

cctctgcaca aatgtgacat ctcaaactct acagaagctg gacagaaact gttcaatatg     1620

ctgaggcttg gaaaatcaga accctggacc ctagcattgg aaaatgttgt aggagcaaag     1680

aacatgaatg taaggccact gctcaactac tttgagccct tatttacctg gctgaaagac     1740

cagaacaaga attcttttgt gggatggagt accgactgga gtccatatgc agacgagtct     1800

aagtacggcc ctccttgtcc ttcctgcccc gctcctgaat ttctcggcgg accttccgtg     1860

ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc     1920

tgcgtggtgg tggacgtgtc ccaagaggat cctgaggtgc agttcaattg gtacgtcgac     1980

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa cagcacctac     2040

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag     2100

tgcaaggtgt ccaacaaggg cctgccaagc agcatcgaga aaaccatcag caaggccaag     2160

ggccagccta gggaacccca ggtttacaca ctgcctccaa gccaagagga aatgaccaag     2220

aaccaggtgt ccctgacctg cctggtcaag ggcttctacc cttccgatat cgccgtggaa     2280

tgggagagca acggccagcc tgagaacaac tacaagacca cacctcctgt gctggacagc     2340

gacggctcat tcttcctgta ctcccggctg accgtggaca agtccagatg gcaagagggc     2400

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     2460

ctgagtctga gcctgggcaa gtga                                            2484


<210>  39
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2-variant3-IgG4amino acid sequence without signal/leader 
       peptide

<400>  39

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Arg Phe Asn 
1               5                   10                  15      


His Val Ala Glu Asp Pro Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Ala Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
        595                 600                 605             


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    610                 615                 620                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
625                 630                 635                 640 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                645                 650                 655     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            660                 665                 670         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        675                 680                 685             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    690                 695                 700                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
705                 710                 715                 720 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                725                 730                 735     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            740                 745                 750         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        755                 760                 765             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    770                 775                 780                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
785                 790                 795                 800 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                805                 810                 815     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            820                 825         


<210>  40
<211>  2484
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-variant4-IgG4 nucleic acid sequence without signal/leader 
       peptide

<400>  40
cagtccacca ttgaggaaca ggccaagaca tttttggaca tgtttaacca caaagccgaa       60

gacctgttct atcaaagttc acttgcttct tggaattata acaccaatat tactgaagag      120

aatgtccaaa acatgaataa tgctggggac aaatggtctg cctttttaaa ggaacagtcc      180

acaattgccc aaatgtatcc actacaagaa attcagaatc ccacagtcaa gcttcagctg      240

caggctcttc agcaaaatgg gtcttcagtg ctctcagaag acaagagcaa acggttgaac      300

acaattctaa atacaatgag caccatctac agtactggaa aagtttgtaa cccggataat      360

ccacaagaat gcttattact tgaaccaggt ttgaatgaaa taatggcaaa cagtttagac      420

tacaatgaga ggctctgggc ttgggaaagc tggagatctg aggtcggcaa gcagctgagg      480

ccattatatg aagagtatgt ggtcttgaaa aatgagatgg cgagagcaaa ccattatgag      540

gactatgggg attattggag aggagactat gaagtaaatg gggtagatgg ctatgactac      600

agccgcggcc agttgattga agatgtggaa catacctttg aagagattaa accattatat      660

gaacatcttc atgcctatgt gagggcaaag ttgatgaatg cctatccttc ctatatcagt      720

ccaattggat gcctccctgc tcatttgctt ggtgatatgt ggggtagatt ttggacaaat      780

ctgtactctt tgacagttcc cttcggacag aaaccaaaca tagatgttac tgatgcaatg      840

gtggaccagg cctgggatgc acagagaata ttcaaggagg ccgagaagtt ctttgtatct      900

gttggtcttc ctaatatgac tcaaggattc tgggaatatt ccatgctaac ggacccagga      960

aatgttcaga aagcagtctg ccatcccaca gcttgggacc tggggaaggg cgacttcagg     1020

atccttatgt gcacaaaggt gacaatggac gacttcctga cagctcatca tgagatgggg     1080

catatccagt atgatatggc atatgctgca caaccttttc tgctaagaaa tggagctaat     1140

gaaggattcc atgaagctgt tggggaaatc atgtcacttt ctgcagccac acctaagcat     1200

ttaaaatcca ttggtcttct gtcacccgat tttcaagaag acaatgaaac agaaataaac     1260

ttcctgctca aacaagcact cacgattgtt gggactctgc catttactta catgttagag     1320

aagtggaggt ggatggtctt taaaggggaa attcccaaag accagtggat gaaaaagtgg     1380

tgggagatga agcgagagat agttggggtg gtggaacctg tgccccatga tgaaacatac     1440

tgtgaccccg catctctgtt ccatgtttct aatgattact cattcattcg atattacaca     1500

aggacccttt accaattcca gtttcaagaa gcactttgtc aagcagctaa acatgaaggc     1560

cctctgcaca aatgtgacat ctcaaactct acagaagctg gacagaaact gttcaatatg     1620

ctgaggcttg gaaaatcaga accctggacc ctagcattgg aaaatgttgt aggagcaaag     1680

aacatgaatg taaggccact gctcaactac tttgagccct tatttacctg gctgaaagac     1740

cagaacaaga attcttttgt gggatggagt accgactgga gtccatatgc agacgagtct     1800

aagtacggcc ctccttgtcc ttcctgcccc gctcctgaat ttctcggcgg accttccgtg     1860

ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc     1920

tgcgtggtgg tggacgtgtc ccaagaggat cctgaggtgc agttcaattg gtacgtcgac     1980

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagttcaa cagcacctac     2040

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag     2100

tgcaaggtgt ccaacaaggg cctgccaagc agcatcgaga aaaccatcag caaggccaag     2160

ggccagccta gggaacccca ggtttacaca ctgcctccaa gccaagagga aatgaccaag     2220

aaccaggtgt ccctgacctg cctggtcaag ggcttctacc cttccgatat cgccgtggaa     2280

tgggagagca acggccagcc tgagaacaac tacaagacca cacctcctgt gctggacagc     2340

gacggctcat tcttcctgta ctcccggctg accgtggaca agtccagatg gcaagagggc     2400

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     2460

ctgagtctga gcctgggcaa gtga                                            2484


<210>  41
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2-variant4-IgG4amino acid sequence without signal/leader 
       peptide

<400>  41

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Ile Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
        595                 600                 605             


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    610                 615                 620                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
625                 630                 635                 640 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                645                 650                 655     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            660                 665                 670         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        675                 680                 685             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    690                 695                 700                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
705                 710                 715                 720 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                725                 730                 735     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            740                 745                 750         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        755                 760                 765             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    770                 775                 780                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
785                 790                 795                 800 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                805                 810                 815     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            820                 825         


<210>  42
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild type hAce2 (based on isoform 1 amino acid sequence; 
       NP_068576.1) without signal/leader peptide

<400>  42

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val Ile 
                725                 730                 735     


Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg Lys 
            740                 745                 750         


Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile Asp 
        755                 760                 765             


Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp Val 
    770                 775                 780                 


Gln Thr Ser Phe 
785             


<210>  43
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV2 RBD (Wuhan) wild type

<400>  43

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
            20                  25                  30          


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
        35                  40                  45              


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
    50                  55                  60                  


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
65                  70                  75                  80  


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
                85                  90                  95      


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
            100                 105                 110         


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
        115                 120                 125             


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
    130                 135                 140                 


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
145                 150                 155                 160 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
                165                 170                 175     


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
            180                 185                 190         


Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
        195                 200                 205             


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser His 
    210                 215                 220                 


His His His His His 
225                 


<210>  44
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV2 RBDSouth Africa Variant

<400>  44

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
            20                  25                  30          


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
        35                  40                  45              


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
    50                  55                  60                  


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
65                  70                  75                  80  


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
                85                  90                  95      


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
            100                 105                 110         


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
        115                 120                 125             


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
    130                 135                 140                 


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
145                 150                 155                 160 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
                165                 170                 175     


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
            180                 185                 190         


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
        195                 200                 205             


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser His 
    210                 215                 220                 


His His His His His 
225                 


<210>  45
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV2 RBD439K 417V

<400>  45

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
            20                  25                  30          


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
        35                  40                  45              


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
    50                  55                  60                  


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
65                  70                  75                  80  


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
                85                  90                  95      


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala 
            100                 105                 110         


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
        115                 120                 125             


Trp Asn Ser Lys Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
    130                 135                 140                 


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
145                 150                 155                 160 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
                165                 170                 175     


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
            180                 185                 190         


Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
        195                 200                 205             


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser His 
    210                 215                 220                 


His His His His His 
225                 


<210>  46
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV2 RBD UK 501Y

<400>  46

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
            20                  25                  30          


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
        35                  40                  45              


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
    50                  55                  60                  


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
65                  70                  75                  80  


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
                85                  90                  95      


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
            100                 105                 110         


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
        115                 120                 125             


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
    130                 135                 140                 


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
145                 150                 155                 160 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
                165                 170                 175     


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
            180                 185                 190         


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
        195                 200                 205             


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser His 
    210                 215                 220                 


His His His His His 
225                 


<210>  47
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV2 RBD 439K

<400>  47

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
            20                  25                  30          


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
        35                  40                  45              


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
    50                  55                  60                  


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
65                  70                  75                  80  


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
                85                  90                  95      


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
            100                 105                 110         


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
        115                 120                 125             


Trp Asn Ser Lys Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
    130                 135                 140                 


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
145                 150                 155                 160 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
                165                 170                 175     


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
            180                 185                 190         


Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
        195                 200                 205             


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser His 
    210                 215                 220                 


His His His His His 
225                 


<210>  48
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  453F

<400>  48

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
            20                  25                  30          


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
        35                  40                  45              


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
    50                  55                  60                  


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
65                  70                  75                  80  


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
                85                  90                  95      


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
            100                 105                 110         


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
        115                 120                 125             


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
    130                 135                 140                 


Leu Phe Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
145                 150                 155                 160 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
                165                 170                 175     


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
            180                 185                 190         


Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
        195                 200                 205             


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser His 
    210                 215                 220                 


His His His His His 
225                 


<210>  49
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV2 RBD 486L

<400>  49

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
            20                  25                  30          


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
        35                  40                  45              


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
    50                  55                  60                  


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
65                  70                  75                  80  


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
                85                  90                  95      


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
            100                 105                 110         


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
        115                 120                 125             


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
    130                 135                 140                 


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
145                 150                 155                 160 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
                165                 170                 175     


Glu Gly Leu Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
            180                 185                 190         


Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
        195                 200                 205             


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser His 
    210                 215                 220                 


His His His His His 
225                 


<210>  50
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  501T

<400>  50

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
            20                  25                  30          


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
        35                  40                  45              


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
    50                  55                  60                  


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
65                  70                  75                  80  


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
                85                  90                  95      


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
            100                 105                 110         


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
        115                 120                 125             


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
    130                 135                 140                 


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
145                 150                 155                 160 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
                165                 170                 175     


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
            180                 185                 190         


Thr Thr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
        195                 200                 205             


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser His 
    210                 215                 220                 


His His His His His 
225                 


<210>  51
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS CoV1 RBD

<400>  51

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ser Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
            20                  25                  30          


Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg 
        35                  40                  45              


Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
    50                  55                  60                  


Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu 
65                  70                  75                  80  


Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys 
                85                  90                  95      


Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala 
            100                 105                 110         


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala 
        115                 120                 125             


Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr 
    130                 135                 140                 


Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp 
145                 150                 155                 160 


Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro 
                165                 170                 175     


Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr 
            180                 185                 190         


Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
        195                 200                 205             


Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser His His 
    210                 215                 220                 


His His His His 
225             


<210>  52
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No. 44; 
       27A/43G/49D/79F/90D/330Y

<400>  52

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp 
        35                  40                  45              


Asp Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  53
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.12; 
       27A/49D/61D/75K/91P/330Y

<400>  53

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asp Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Lys Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  54
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.16; 
       27A/43G/61D/81R/91P/330Y

<400>  54

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Arg Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  55
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.17; 
       27A/49D/61D/79F/90S/330Y

<400>  55

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asp Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Ser Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  56
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.33; 
       27A/43G/49D/79F/91P/330Y

<400>  56

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp 
        35                  40                  45              


Asp Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  57
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.24; 
       27A/43G/49D/61D/76R/330Y

<400>  57

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp 
        35                  40                  45              


Asp Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Arg Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  58
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.27; 
       43G/49D/79F/90D/330Y

<400>  58

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp 
        35                  40                  45              


Asp Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  59
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.43; 
       27A/43G/61D/75K/90D/330Y

<400>  59

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Lys Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  60
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.35; 
       27A/43G/61D/79F/90S/330Y

<400>  60

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Ser Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  61
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.39; 
       27A/49D/61D/81R/92A/330Y

<400>  61

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asp Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Arg Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Ala Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  62
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.44; 
       27A/43G/49D/79F/90D/330Y; without leader sequence

<400>  62

Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp Asp 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  63
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.12; 
       27A/49D/61D/75K/91P/330Y; without leader sequence

<400>  63

Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asp 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Lys Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  64
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.16; 
       27A/43G/61D/81R/91P/330Y; without leader sequence

<400>  64

Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Arg 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  65
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.17; 
       27A/49D/61D/79F/90S/330Y; without leader sequence

<400>  65

Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asp 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Ser Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  66
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.33; 
       27A/43G/49D/79F/91P/330Y; without leader sequence

<400>  66

Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp Asp 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  67
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.24; 
       27A/43G/49D/61D/76R/330Y; without leader sequence

<400>  67

Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp Asp 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Arg Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  68
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.27; 
       43G/49D/79F/90D/330Y; without leader sequence

<400>  68

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp Asp 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  69
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.43; 
       27A/43G/61D/75K/90D/330Y; without leader sequence

<400>  69

Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Lys Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asp Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  70
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.35; 
       27A/43G/61D/79F/90S/330Y; without leader sequence

<400>  70

Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Gly Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Ser Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  71
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hAce mutant clone No.39; 
       27A/49D/61D/81R/92A/330Y; without leader sequence

<400>  71

Gln Ser Thr Ile Glu Glu Gln Ala Lys Ala Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asp 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asp Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Arg 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Ala Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  72
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 5 amino acid sequence with signal/leader peptide

<400>  72

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Arg Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  73
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 6 amino acid sequence with signal/leader peptide

<400>  73

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  74
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 5 amino acid sequence without signal/leader peptide

<400>  74

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Arg Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  75
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAce2 variant 6 amino acid sequence without signal/leader peptide

<400>  75

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  76
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of native signal/leader peptide

<400>  76

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala 
    


<210>  77
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human IgG4 Fc domain

<400>  77

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  78
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgM Fc domain

<400>  78

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp 
            100                 105                 110         


Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala Ser 
        115                 120                 125             


Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp Leu 
    130                 135                 140                 


Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly Glu 
145                 150                 155                 160 


Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr 
                165                 170                 175     


Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser 
            180                 185                 190         


Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro 
        195                 200                 205             


Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly Val Ala Leu His Arg Pro 
    210                 215                 220                 


Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu 
225                 230                 235                 240 


Ser Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser Pro Ala Asp Val 
                245                 250                 255     


Phe Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr 
            260                 265                 270         


Val Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe 
        275                 280                 285             


Ala His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp Asn Thr Gly Glu 
    290                 295                 300                 


Thr Tyr Thr Cys Val Val Ala His Glu Ala Leu Pro Asn Arg Val Thr 
305                 310                 315                 320 


Glu Arg Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val 
                325                 330                 335     


Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            340                 345             


<210>  79
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgM (without N-terminal "I") Fc domain

<400>  79

Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp Gly 
1               5                   10                  15      


Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly 
            20                  25                  30          


Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys Gln 
        35                  40                  45              


Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys Glu 
    50                  55                  60                  


Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys Glu 
65                  70                  75                  80  


Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His Arg 
                85                  90                  95      


Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp Gln 
            100                 105                 110         


Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile 
        115                 120                 125             


Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp Leu Thr 
    130                 135                 140                 


Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala 
145                 150                 155                 160 


Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr Phe 
                165                 170                 175     


Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly 
            180                 185                 190         


Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro Leu 
        195                 200                 205             


Lys Gln Thr Ile Ser Arg Pro Lys Gly Val Ala Leu His Arg Pro Asp 
    210                 215                 220                 


Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser 
225                 230                 235                 240 


Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser Pro Ala Asp Val Phe 
                245                 250                 255     


Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val 
            260                 265                 270         


Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala 
        275                 280                 285             


His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr 
    290                 295                 300                 


Tyr Thr Cys Val Val Ala His Glu Ala Leu Pro Asn Arg Val Thr Glu 
305                 310                 315                 320 


Arg Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser 
                325                 330                 335     


Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            340                 345         


<210>  80
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild type hAce2 amino acids 1-615 (based on isoform 1 amino acid 
       sequence; NP_068576.1)

<400>  80

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  81
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild type hAce2 amino acids 18-615 (based on isoform 1 amino acid
       sequence; NP_068576.1) without signal/leader peptide

<400>  81

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  82
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild type hAce2 amino acids 1-740 (based on isoform 1 amino acid 
       sequence; NP_068576.1)

<400>  82

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser 
            740 


<210>  83
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild type hAce2 amino acids 18-740 (based on isoform 1 amino acid
       sequence; NP_068576.1) without signal/leader peptide

<400>  83

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser 
            


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide for detection using Mass Spectrometry

<400>  84

Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg 
1               5                   10          


<210>  85
<211>  4893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector genome encoding hAce2(variant 2)-IgG1-FC


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE promoter/enhancer

<220>
<221>  misc_feature
<222>  (198)..(863)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta-actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1942)..(3786)
<223>  hAce2HL

<220>
<221>  misc_feature
<222>  (1942)..(4482)
<223>  hAce2HL

<220>
<221>  misc_feature
<222>  (1942)..(4482)
<223>  hAce2(variant 2)(GTP14HL)-IgG1

<220>
<221>  misc_feature
<222>  (3787)..(4482)
<223>  IgG1Fc

<220>
<221>  polyA_signal
<222>  (4549)..(4675)
<223>  Rabbit globin polyA

<220>
<221>  repeat_region
<222>  (4764)..(4893)
<223>  3' ITR

<400>  85
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcccgccac catgtcaagc tcttcctggc tccttctcag ccttgttgct     1980

gtaactgctg ctcagtccac cattgaggaa caggccaaga catttttgga catgtttaac     2040

cacaaagccg aagacctgtt ctatcaaagt tcacttgctg cttggaatta taacaccaat     2100

attactgaag agaatgtcca aaacatgaat aacgctgggg acaaatggtc tgccttttta     2160

aaggaacagt ccacatttgc ccaaatgtat ccactacaag aaattcagaa tcccacagtc     2220

aagcttcagc tgcaggctct tcagcaaaat gggtcttcag tgctctcaga agacaagagc     2280

aaacggttga acacaattct aaatacaatg agcaccatct acagtactgg aaaagtttgt     2340

aacccggata atccacaaga atgcttatta cttgaaccag gtttgaatga aataatggca     2400

aacagtttag actacaatga gaggctctgg gcttgggaaa gctggagatc tgaggtcggc     2460

aagcagctga ggccattata tgaagagtat gtggtcttga aaaatgagat ggcgagagca     2520

aaccattatg aggactatgg ggattattgg agaggagact atgaagtaaa tggggtagat     2580

ggctatgact acagccgcgg ccagttgatt gaagatgtgg aacatacctt tgaagagatt     2640

aaaccattat atgaacatct tcatgcctat gtgagggcaa agttgatgaa tgcctatcct     2700

tcctatatca gtccaattgg atgcctccct gctcatttgc ttggtgatat gtggggtaga     2760

ttttggacaa atctgtactc tttgacagtt cccttcggac agaaaccaaa catagatgtt     2820

actgatgcaa tggtggacca ggcctgggat gcacagagaa tattcaagga ggccgagaag     2880

ttctttgtat ctgttggtct tcctaatatg actcaaggat tctgggaata ttccatgcta     2940

acggacccag gaaatgttca gaaagcagtc tgccttccca cagcttggga cctggggaag     3000

ggcgacttca ggatccttat gtgcacaaag gtgacaatgg acgacttcct gacagctcat     3060

catgagatgg ggcatatcca gtatgatatg gcatatgctg cacaaccttt tctgctaaga     3120

aatggagcta atgaaggatt ccatgaagct gttggggaaa tcatgtcact ttctgcagcc     3180

acacctaagc atttaaaatc cattggtctt ctgtcacccg attttcaaga agacaatgaa     3240

acagaaataa acttcctgct caaacaagca ctcacgattg ttgggactct gccatttact     3300

tacatgttag agaagtggag gtggatggtc tttaaagggg aaattcccaa agaccagtgg     3360

atgaaaaagt ggtgggagat gaagcgagag atagttgggg tggtggaacc tgtgccccat     3420

gatgaaacat actgtgaccc cgcatctctg ttccatgttt ctaatgatta ctcattcatt     3480

cgatattaca caaggaccct ttaccaattc cagtttcaag aagcactttg tcaagcagct     3540

aaacatgaag gccctctgca caaatgtgac atctcaaact ctacagaagc tggacagaaa     3600

ctgttcaata tgctgaggct tggaaaatca gaaccctgga ccctagcatt ggaaaatgtt     3660

gtaggagcaa agaacatgaa tgtaaggcca ctgctcaact actttgagcc cttatttacc     3720

tggctgaaag accagaacaa gaattctttt gtgggatgga gtaccgactg gagtccatat     3780

gcagacgaac ccaagagctg cgacaagacc cacacctgtc ctccatgtcc tgctccagaa     3840

ctgctcggcg gaccttccgt gttcctgttt cctccaaagc ctaaggacac cctgatgatc     3900

agcagaaccc ctgaagtgac ctgcgtggtg gtggatgtgt cccacgagga tcccgaagtg     3960

aagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag     4020

gaacagtaca acagcaccta cagagtggtg tccgtgctga ccgtgctgca ccaggattgg     4080

ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg ccctgcctgc tcctatcgag     4140

aaaaccatca gcaaggccaa gggccagcct agggaacccc aggtttacac actgcctcca     4200

agcagggacg agctgaccaa gaatcaggtg tccctgacct gcctcgtgaa gggcttctac     4260

ccttccgata tcgccgtgga atgggagagc aacggccagc ctgagaacaa ctacaagaca     4320

acccctcctg tgctggacag cgacggctca ttcttcctgt acagcaagct gacagtggac     4380

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     4440

aaccactaca cccagaagtc cctgagcctg tctcctggaa aatgatgagg tacctctaga     4500

gtcgacccgg gcggcctcga ggacggggtg aactacgcct gaggatccga tctttttccc     4560

tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa     4620

aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagc     4680

aattcgttga tctgaatttc gaccacccat aatacccatt accctggtag ataagtagca     4740

tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct     4800

gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc     4860

ccgggcggcc tcagtgagcg agcgagcgcg cag                                  4893


<210>  86
<211>  4478
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette encoding hAce2(variant 2)-IgG1-FC


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE promoter/enhancer

<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (385)..(666)
<223>  CB promoter

<220>
<221>  Intron
<222>  (759)..(1731)
<223>  chicken beta-actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1745)..(4285)
<223>  hAce2(variant 2)(GTP14HL)-IgG1

<220>
<221>  misc_feature
<222>  (1745)..(3589)
<223>  hAce2HL

<220>
<221>  misc_feature
<222>  (3590)..(4285)
<223>  IgG1Fc

<220>
<221>  polyA_signal
<222>  (4352)..(4478)
<223>  Rabbit globin polyA

<400>  86
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcccgc     1740

caccatgtca agctcttcct ggctccttct cagccttgtt gctgtaactg ctgctcagtc     1800

caccattgag gaacaggcca agacattttt ggacatgttt aaccacaaag ccgaagacct     1860

gttctatcaa agttcacttg ctgcttggaa ttataacacc aatattactg aagagaatgt     1920

ccaaaacatg aataacgctg gggacaaatg gtctgccttt ttaaaggaac agtccacatt     1980

tgcccaaatg tatccactac aagaaattca gaatcccaca gtcaagcttc agctgcaggc     2040

tcttcagcaa aatgggtctt cagtgctctc agaagacaag agcaaacggt tgaacacaat     2100

tctaaataca atgagcacca tctacagtac tggaaaagtt tgtaacccgg ataatccaca     2160

agaatgctta ttacttgaac caggtttgaa tgaaataatg gcaaacagtt tagactacaa     2220

tgagaggctc tgggcttggg aaagctggag atctgaggtc ggcaagcagc tgaggccatt     2280

atatgaagag tatgtggtct tgaaaaatga gatggcgaga gcaaaccatt atgaggacta     2340

tggggattat tggagaggag actatgaagt aaatggggta gatggctatg actacagccg     2400

cggccagttg attgaagatg tggaacatac ctttgaagag attaaaccat tatatgaaca     2460

tcttcatgcc tatgtgaggg caaagttgat gaatgcctat ccttcctata tcagtccaat     2520

tggatgcctc cctgctcatt tgcttggtga tatgtggggt agattttgga caaatctgta     2580

ctctttgaca gttcccttcg gacagaaacc aaacatagat gttactgatg caatggtgga     2640

ccaggcctgg gatgcacaga gaatattcaa ggaggccgag aagttctttg tatctgttgg     2700

tcttcctaat atgactcaag gattctggga atattccatg ctaacggacc caggaaatgt     2760

tcagaaagca gtctgccttc ccacagcttg ggacctgggg aagggcgact tcaggatcct     2820

tatgtgcaca aaggtgacaa tggacgactt cctgacagct catcatgaga tggggcatat     2880

ccagtatgat atggcatatg ctgcacaacc ttttctgcta agaaatggag ctaatgaagg     2940

attccatgaa gctgttgggg aaatcatgtc actttctgca gccacaccta agcatttaaa     3000

atccattggt cttctgtcac ccgattttca agaagacaat gaaacagaaa taaacttcct     3060

gctcaaacaa gcactcacga ttgttgggac tctgccattt acttacatgt tagagaagtg     3120

gaggtggatg gtctttaaag gggaaattcc caaagaccag tggatgaaaa agtggtggga     3180

gatgaagcga gagatagttg gggtggtgga acctgtgccc catgatgaaa catactgtga     3240

ccccgcatct ctgttccatg tttctaatga ttactcattc attcgatatt acacaaggac     3300

cctttaccaa ttccagtttc aagaagcact ttgtcaagca gctaaacatg aaggccctct     3360

gcacaaatgt gacatctcaa actctacaga agctggacag aaactgttca atatgctgag     3420

gcttggaaaa tcagaaccct ggaccctagc attggaaaat gttgtaggag caaagaacat     3480

gaatgtaagg ccactgctca actactttga gcccttattt acctggctga aagaccagaa     3540

caagaattct tttgtgggat ggagtaccga ctggagtcca tatgcagacg aacccaagag     3600

ctgcgacaag acccacacct gtcctccatg tcctgctcca gaactgctcg gcggaccttc     3660

cgtgttcctg tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt     3720

gacctgcgtg gtggtggatg tgtcccacga ggatcccgaa gtgaagttca attggtacgt     3780

ggacggcgtg gaagtgcaca acgccaagac caagcctaga gaggaacagt acaacagcac     3840

ctacagagtg gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaagagta     3900

caagtgcaag gtgtccaaca aggccctgcc tgctcctatc gagaaaacca tcagcaaggc     3960

caagggccag cctagggaac cccaggttta cacactgcct ccaagcaggg acgagctgac     4020

caagaatcag gtgtccctga cctgcctcgt gaagggcttc tacccttccg atatcgccgt     4080

ggaatgggag agcaacggcc agcctgagaa caactacaag acaacccctc ctgtgctgga     4140

cagcgacggc tcattcttcc tgtacagcaa gctgacagtg gacaagtcca ggtggcagca     4200

gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa     4260

gtccctgagc ctgtctcctg gaaaatgatg aggtacctct agagtcgacc cgggcggcct     4320

cgaggacggg gtgaactacg cctgaggatc cgatcttttt ccctctgcca aaaattatgg     4380

ggacatcatg aagccccttg agcatctgac ttctggctaa taaaggaaat ttattttcat     4440

tgcaatagtg tgttggaatt ttttgtgtct ctcactcg                             4478


<210>  87
<211>  4893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector genome comprising hAce2MR27HL-IgG1Fc decoy


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5"ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE promoter/enhancer

<220>
<221>  misc_feature
<222>  (198)..(863)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1942)..(4488)
<223>  MR27HLFc1 decoy

<220>
<221>  misc_feature
<222>  (1942)..(3786)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (3787)..(4482)
<223>  IgGFc1

<220>
<221>  polyA_signal
<222>  (4549)..(4675)
<223>  Rabbit globin polyA

<220>
<221>  repeat_region
<222>  (4764)..(4893)
<223>  3'ITR

<400>  87
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcccgccac catgtcaagc tcttcctggc tccttctcag ccttgttgct     1980

gtaactgctg ctcagtccac cattgaggaa caggccaaga catttttgga catgtttaac     2040

cacaaagccg aagacctgtt ctatcaaagt tcacttgctt cttggaatta caacaccaat     2100

attactgaag agaatgtcca aaacatgaat aatgctgggg acaaatggtc tgccttttta     2160

aaggaacagt ccacacttgc ccaaatgtat ccactacaag aaattcagaa tcccacagtc     2220

aagcttcagc tgcaggctct tcagcaaaat gggtcttcag tgctctcaga agacaagagc     2280

aaacggttga acacaattct aaatacaatg agcaccatct acagtactgg aaaagtttgt     2340

aacccggata atccacaaga atgcttatta cttgaaccag gtttgaatga aataatggca     2400

aacagtttag actacaatga gaggctctgg gcttgggaaa gctggagatc tgaggtcggc     2460

aagcagctga ggccattata tgaagagtat gtggtcttga aaaatgagat ggcgagagca     2520

aaccattatg aggactatgg ggattattgg agaggagact atgaagtaaa tggggtagat     2580

ggctatgact acagccgcgg ccagttgatt gaagatgtgg aacatacctt tgaagagatt     2640

aaaccattat atgaacatct tcatgcctat gtgagggcaa agttgatgaa tgcctatcct     2700

tcctatatca gtccaattgg atgcctccct gctcatttgc ttggtgatat gtggggtaga     2760

ttttggacaa atctgtactc tttgacagtt cccttcggac agaaaccaaa catagatgtt     2820

actgatgcaa tggtggacca ggcctgggat gcacagagaa tattcaagga ggccgagaag     2880

ttctttgtat ctgttggtct tcctaatatg actcaaggat tctgggaata ttccatgcta     2940

acggacccag gaaatgttca gaaagcagtc tgccttccca cagcttggga cctggggaag     3000

ggcgacttca ggatccttat gtgcacaaag gtgacaatgg acgacttcct gacagctcat     3060

catgagatgg ggcatatcca gtatgatatg gcatatgctg cacaaccttt tctgctaaga     3120

aatggagcta atgaaggatt ccatgaagct gttggggaaa tcatgtcact ttctgcagcc     3180

acacctaagc atttaaaatc cattggtctt ctgtcacccg attttcaaga agacaatgaa     3240

acagaaataa acttcctgct caaacaagca ctcacgattg ttgggactct gccatttact     3300

tacatgttag agaagtggag gtggatggtc tttaaagggg aaattcccaa agaccagtgg     3360

atgaaaaagt ggtgggagat gaagcgagag atagttgggg tggtggaacc tgtgccccat     3420

gatgaaacat actgtgaccc cgcatctctg ttccatgttt ctaatgatta ctcattcatt     3480

cgatattaca caaggaccct ttaccaattc cagtttcaag aagcactttg tcaagcagct     3540

aaacatgaag gccctctgca caaatgtgac atctcaaact ctacagaagc tggacagaaa     3600

ctgttcaata tgctgaggct tggaaaatca gaaccctgga ccctagcatt ggaaaatgtt     3660

gtaggagcaa agaacatgaa tgtaaggcca ctgctcaact actttgagcc cttatttacc     3720

tggctgaaag accagaacaa gaattctttt gtgggatgga gtaccgactg gagtccatat     3780

gcagacgaac ccaagagctg cgacaagacc cacacctgtc ctccatgtcc tgctccagaa     3840

ctgctcggcg gaccttccgt gttcctgttt cctccaaagc ctaaggacac cctgatgatc     3900

agcagaaccc ctgaagtgac ctgcgtggtg gtggatgtgt cccacgagga tcccgaagtg     3960

aagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag     4020

gaacagtaca acagcaccta cagagtggtg tccgtgctga ccgtgctgca ccaggattgg     4080

ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg ccctgcctgc tcctatcgag     4140

aaaaccatca gcaaggccaa gggccagcct agggaacccc aggtttacac actgcctcca     4200

agcagggacg agctgaccaa gaatcaggtg tccctgacct gcctcgtgaa gggcttctac     4260

ccttccgata tcgccgtgga atgggagagc aacggccagc ctgagaacaa ctacaagaca     4320

acccctcctg tgctggacag cgacggctca ttcttcctgt acagcaagct gacagtggac     4380

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     4440

aaccactaca cccagaagtc cctgagcctg tctcctggaa aatgatgagg tacctctaga     4500

gtcgacccgg gcggcctcga ggacggggtg aactacgcct gaggatccga tctttttccc     4560

tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa     4620

aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagc     4680

aattcgttga tctgaatttc gaccacccat aatacccatt accctggtag ataagtagca     4740

tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct     4800

gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc     4860

ccgggcggcc tcagtgagcg agcgagcgcg cag                                  4893


<210>  88
<211>  4478
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette comprising hAce2MR27HL-IgG1Fc decoy


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE promoter/enhancer

<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (385)..(666)
<223>  CB promoter

<220>
<221>  Intron
<222>  (759)..(1731)
<223>  chicken beta actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1745)..(4285)
<223>  ME27HLFc1 decoy

<220>
<221>  misc_feature
<222>  (1745)..(3589)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (3590)..(4285)
<223>  IgG1Fc

<220>
<221>  polyA_signal
<222>  (4352)..(4478)
<223>  rabbit globin polyA

<400>  88
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcccgc     1740

caccatgtca agctcttcct ggctccttct cagccttgtt gctgtaactg ctgctcagtc     1800

caccattgag gaacaggcca agacattttt ggacatgttt aaccacaaag ccgaagacct     1860

gttctatcaa agttcacttg cttcttggaa ttacaacacc aatattactg aagagaatgt     1920

ccaaaacatg aataatgctg gggacaaatg gtctgccttt ttaaaggaac agtccacact     1980

tgcccaaatg tatccactac aagaaattca gaatcccaca gtcaagcttc agctgcaggc     2040

tcttcagcaa aatgggtctt cagtgctctc agaagacaag agcaaacggt tgaacacaat     2100

tctaaataca atgagcacca tctacagtac tggaaaagtt tgtaacccgg ataatccaca     2160

agaatgctta ttacttgaac caggtttgaa tgaaataatg gcaaacagtt tagactacaa     2220

tgagaggctc tgggcttggg aaagctggag atctgaggtc ggcaagcagc tgaggccatt     2280

atatgaagag tatgtggtct tgaaaaatga gatggcgaga gcaaaccatt atgaggacta     2340

tggggattat tggagaggag actatgaagt aaatggggta gatggctatg actacagccg     2400

cggccagttg attgaagatg tggaacatac ctttgaagag attaaaccat tatatgaaca     2460

tcttcatgcc tatgtgaggg caaagttgat gaatgcctat ccttcctata tcagtccaat     2520

tggatgcctc cctgctcatt tgcttggtga tatgtggggt agattttgga caaatctgta     2580

ctctttgaca gttcccttcg gacagaaacc aaacatagat gttactgatg caatggtgga     2640

ccaggcctgg gatgcacaga gaatattcaa ggaggccgag aagttctttg tatctgttgg     2700

tcttcctaat atgactcaag gattctggga atattccatg ctaacggacc caggaaatgt     2760

tcagaaagca gtctgccttc ccacagcttg ggacctgggg aagggcgact tcaggatcct     2820

tatgtgcaca aaggtgacaa tggacgactt cctgacagct catcatgaga tggggcatat     2880

ccagtatgat atggcatatg ctgcacaacc ttttctgcta agaaatggag ctaatgaagg     2940

attccatgaa gctgttgggg aaatcatgtc actttctgca gccacaccta agcatttaaa     3000

atccattggt cttctgtcac ccgattttca agaagacaat gaaacagaaa taaacttcct     3060

gctcaaacaa gcactcacga ttgttgggac tctgccattt acttacatgt tagagaagtg     3120

gaggtggatg gtctttaaag gggaaattcc caaagaccag tggatgaaaa agtggtggga     3180

gatgaagcga gagatagttg gggtggtgga acctgtgccc catgatgaaa catactgtga     3240

ccccgcatct ctgttccatg tttctaatga ttactcattc attcgatatt acacaaggac     3300

cctttaccaa ttccagtttc aagaagcact ttgtcaagca gctaaacatg aaggccctct     3360

gcacaaatgt gacatctcaa actctacaga agctggacag aaactgttca atatgctgag     3420

gcttggaaaa tcagaaccct ggaccctagc attggaaaat gttgtaggag caaagaacat     3480

gaatgtaagg ccactgctca actactttga gcccttattt acctggctga aagaccagaa     3540

caagaattct tttgtgggat ggagtaccga ctggagtcca tatgcagacg aacccaagag     3600

ctgcgacaag acccacacct gtcctccatg tcctgctcca gaactgctcg gcggaccttc     3660

cgtgttcctg tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt     3720

gacctgcgtg gtggtggatg tgtcccacga ggatcccgaa gtgaagttca attggtacgt     3780

ggacggcgtg gaagtgcaca acgccaagac caagcctaga gaggaacagt acaacagcac     3840

ctacagagtg gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaagagta     3900

caagtgcaag gtgtccaaca aggccctgcc tgctcctatc gagaaaacca tcagcaaggc     3960

caagggccag cctagggaac cccaggttta cacactgcct ccaagcaggg acgagctgac     4020

caagaatcag gtgtccctga cctgcctcgt gaagggcttc tacccttccg atatcgccgt     4080

ggaatgggag agcaacggcc agcctgagaa caactacaag acaacccctc ctgtgctgga     4140

cagcgacggc tcattcttcc tgtacagcaa gctgacagtg gacaagtcca ggtggcagca     4200

gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa     4260

gtccctgagc ctgtctcctg gaaaatgatg aggtacctct agagtcgacc cgggcggcct     4320

cgaggacggg gtgaactacg cctgaggatc cgatcttttt ccctctgcca aaaattatgg     4380

ggacatcatg aagccccttg agcatctgac ttctggctaa taaaggaaat ttattttcat     4440

tgcaatagtg tgttggaatt ttttgtgtct ctcactcg                             4478


<210>  89
<211>  4884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector genome comprising hAce2(variant 2)(GTP14HL)-IgG1Fc decoy  
       revised linker


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE promoter/enhancer

<220>
<221>  misc_feature
<222>  (198)..(863)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1942)..(4473)
<223>  hAce2(variant 2)(GTP14HL)-IgG1-revised linker

<220>
<221>  misc_feature
<222>  (1942)..(3786)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (3793)..(4473)
<223>  IgG1Fc

<220>
<221>  polyA_signal
<222>  (4540)..(4666)
<223>  Rabbit globin polyA

<220>
<221>  repeat_region
<222>  (4755)..(4884)
<223>  3'ITR

<400>  89
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcccgccac catgtcaagc tcttcctggc tccttctcag ccttgttgct     1980

gtaactgctg ctcagtccac cattgaggaa caggccaaga catttttgga catgtttaac     2040

cacaaagccg aagacctgtt ctatcaaagt tcacttgctg cttggaatta taacaccaat     2100

attactgaag agaatgtcca aaacatgaat aacgctgggg acaaatggtc tgccttttta     2160

aaggaacagt ccacatttgc ccaaatgtat ccactacaag aaattcagaa tcccacagtc     2220

aagcttcagc tgcaggctct tcagcaaaat gggtcttcag tgctctcaga agacaagagc     2280

aaacggttga acacaattct aaatacaatg agcaccatct acagtactgg aaaagtttgt     2340

aacccggata atccacaaga atgcttatta cttgaaccag gtttgaatga aataatggca     2400

aacagtttag actacaatga gaggctctgg gcttgggaaa gctggagatc tgaggtcggc     2460

aagcagctga ggccattata tgaagagtat gtggtcttga aaaatgagat ggcgagagca     2520

aaccattatg aggactatgg ggattattgg agaggagact atgaagtaaa tggggtagat     2580

ggctatgact acagccgcgg ccagttgatt gaagatgtgg aacatacctt tgaagagatt     2640

aaaccattat atgaacatct tcatgcctat gtgagggcaa agttgatgaa tgcctatcct     2700

tcctatatca gtccaattgg atgcctccct gctcatttgc ttggtgatat gtggggtaga     2760

ttttggacaa atctgtactc tttgacagtt cccttcggac agaaaccaaa catagatgtt     2820

actgatgcaa tggtggacca ggcctgggat gcacagagaa tattcaagga ggccgagaag     2880

ttctttgtat ctgttggtct tcctaatatg actcaaggat tctgggaata ttccatgcta     2940

acggacccag gaaatgttca gaaagcagtc tgccttccca cagcttggga cctggggaag     3000

ggcgacttca ggatccttat gtgcacaaag gtgacaatgg acgacttcct gacagctcat     3060

catgagatgg ggcatatcca gtatgatatg gcatatgctg cacaaccttt tctgctaaga     3120

aatggagcta atgaaggatt ccatgaagct gttggggaaa tcatgtcact ttctgcagcc     3180

acacctaagc atttaaaatc cattggtctt ctgtcacccg attttcaaga agacaatgaa     3240

acagaaataa acttcctgct caaacaagca ctcacgattg ttgggactct gccatttact     3300

tacatgttag agaagtggag gtggatggtc tttaaagggg aaattcccaa agaccagtgg     3360

atgaaaaagt ggtgggagat gaagcgagag atagttgggg tggtggaacc tgtgccccat     3420

gatgaaacat actgtgaccc cgcatctctg ttccatgttt ctaatgatta ctcattcatt     3480

cgatattaca caaggaccct ttaccaattc cagtttcaag aagcactttg tcaagcagct     3540

aaacatgaag gccctctgca caaatgtgac atctcaaact ctacagaagc tggacagaaa     3600

ctgttcaata tgctgaggct tggaaaatca gaaccctgga ccctagcatt ggaaaatgtt     3660

gtaggagcaa agaacatgaa tgtaaggcca ctgctcaact actttgagcc cttatttacc     3720

tggctgaaag accagaacaa gaattctttt gtgggatgga gtaccgactg gagtccatat     3780

gcagacggaa gtgacaagac ccacacctgt cctccatgtc ctgctccaga actgctcggc     3840

ggaccttccg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc     3900

cctgaagtga cctgcgtggt ggtggatgtg tcccacgagg atcccgaagt gaagttcaat     3960

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac     4020

aacagcacct acagagtggt gtccgtgctg accgtgctgc accaggattg gctgaacggc     4080

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg ctcctatcga gaaaaccatc     4140

agcaaggcca agggccagcc tagggaaccc caggtttaca cactgcctcc aagcagggac     4200

gagctgacca agaatcaggt gtccctgacc tgcctcgtga agggcttcta cccttccgat     4260

atcgccgtgg aatgggagag caacggccag cctgagaaca actacaagac aacccctcct     4320

gtgctggaca gcgacggctc attcttcctg tacagcaagc tgacagtgga caagtccagg     4380

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     4440

acccagaagt ccctgagcct gtctcctgga aaatgatgag gtacctctag agtcgacccg     4500

ggcggcctcg aggacggggt gaactacgcc tgaggatccg atctttttcc ctctgccaaa     4560

aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata aaggaaattt     4620

attttcattg caatagtgtg ttggaatttt ttgtgtctct cactcggaag caattcgttg     4680

atctgaattt cgaccaccca taatacccat taccctggta gataagtagc atggcgggtt     4740

aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4800

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4860

ctcagtgagc gagcgagcgc gcag                                            4884


<210>  90
<211>  4469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette comprising hAce2(variant 2)(GTP14HL)-IgG1Fc 
       decoy  revised linker


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE promoter/enhancer

<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (385)..(666)
<223>  CB promoter

<220>
<221>  Intron
<222>  (759)..(1731)
<223>  chicken beta-actin promoter (chimeric intron)

<220>
<221>  misc_feature
<222>  (1745)..(4276)
<223>  hAce2(variant 2)(GTP14HL)-IgG1 revised linker

<220>
<221>  misc_feature
<222>  (1745)..(3589)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (3596)..(4276)
<223>  IgG1Fc

<220>
<221>  polyA_signal
<222>  (4343)..(4469)
<223>  Rabbit Globin polyA

<400>  90
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcccgc     1740

caccatgtca agctcttcct ggctccttct cagccttgtt gctgtaactg ctgctcagtc     1800

caccattgag gaacaggcca agacattttt ggacatgttt aaccacaaag ccgaagacct     1860

gttctatcaa agttcacttg ctgcttggaa ttataacacc aatattactg aagagaatgt     1920

ccaaaacatg aataacgctg gggacaaatg gtctgccttt ttaaaggaac agtccacatt     1980

tgcccaaatg tatccactac aagaaattca gaatcccaca gtcaagcttc agctgcaggc     2040

tcttcagcaa aatgggtctt cagtgctctc agaagacaag agcaaacggt tgaacacaat     2100

tctaaataca atgagcacca tctacagtac tggaaaagtt tgtaacccgg ataatccaca     2160

agaatgctta ttacttgaac caggtttgaa tgaaataatg gcaaacagtt tagactacaa     2220

tgagaggctc tgggcttggg aaagctggag atctgaggtc ggcaagcagc tgaggccatt     2280

atatgaagag tatgtggtct tgaaaaatga gatggcgaga gcaaaccatt atgaggacta     2340

tggggattat tggagaggag actatgaagt aaatggggta gatggctatg actacagccg     2400

cggccagttg attgaagatg tggaacatac ctttgaagag attaaaccat tatatgaaca     2460

tcttcatgcc tatgtgaggg caaagttgat gaatgcctat ccttcctata tcagtccaat     2520

tggatgcctc cctgctcatt tgcttggtga tatgtggggt agattttgga caaatctgta     2580

ctctttgaca gttcccttcg gacagaaacc aaacatagat gttactgatg caatggtgga     2640

ccaggcctgg gatgcacaga gaatattcaa ggaggccgag aagttctttg tatctgttgg     2700

tcttcctaat atgactcaag gattctggga atattccatg ctaacggacc caggaaatgt     2760

tcagaaagca gtctgccttc ccacagcttg ggacctgggg aagggcgact tcaggatcct     2820

tatgtgcaca aaggtgacaa tggacgactt cctgacagct catcatgaga tggggcatat     2880

ccagtatgat atggcatatg ctgcacaacc ttttctgcta agaaatggag ctaatgaagg     2940

attccatgaa gctgttgggg aaatcatgtc actttctgca gccacaccta agcatttaaa     3000

atccattggt cttctgtcac ccgattttca agaagacaat gaaacagaaa taaacttcct     3060

gctcaaacaa gcactcacga ttgttgggac tctgccattt acttacatgt tagagaagtg     3120

gaggtggatg gtctttaaag gggaaattcc caaagaccag tggatgaaaa agtggtggga     3180

gatgaagcga gagatagttg gggtggtgga acctgtgccc catgatgaaa catactgtga     3240

ccccgcatct ctgttccatg tttctaatga ttactcattc attcgatatt acacaaggac     3300

cctttaccaa ttccagtttc aagaagcact ttgtcaagca gctaaacatg aaggccctct     3360

gcacaaatgt gacatctcaa actctacaga agctggacag aaactgttca atatgctgag     3420

gcttggaaaa tcagaaccct ggaccctagc attggaaaat gttgtaggag caaagaacat     3480

gaatgtaagg ccactgctca actactttga gcccttattt acctggctga aagaccagaa     3540

caagaattct tttgtgggat ggagtaccga ctggagtcca tatgcagacg gaagtgacaa     3600

gacccacacc tgtcctccat gtcctgctcc agaactgctc ggcggacctt ccgtgttcct     3660

gtttcctcca aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgcgt     3720

ggtggtggat gtgtcccacg aggatcccga agtgaagttc aattggtacg tggacggcgt     3780

ggaagtgcac aacgccaaga ccaagcctag agaggaacag tacaacagca cctacagagt     3840

ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac ggcaaagagt acaagtgcaa     3900

ggtgtccaac aaggccctgc ctgctcctat cgagaaaacc atcagcaagg ccaagggcca     3960

gcctagggaa ccccaggttt acacactgcc tccaagcagg gacgagctga ccaagaatca     4020

ggtgtccctg acctgcctcg tgaagggctt ctacccttcc gatatcgccg tggaatggga     4080

gagcaacggc cagcctgaga acaactacaa gacaacccct cctgtgctgg acagcgacgg     4140

ctcattcttc ctgtacagca agctgacagt ggacaagtcc aggtggcagc agggcaacgt     4200

gttcagctgc agcgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgag     4260

cctgtctcct ggaaaatgat gaggtacctc tagagtcgac ccgggcggcc tcgaggacgg     4320

ggtgaactac gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat     4380

gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt     4440

gtgttggaat tttttgtgtc tctcactcg                                       4469


<210>  91
<211>  4884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector genome comprising hAce2MR27HL-IgG1Fc decoy revised linker


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE promoter/enhancer

<220>
<221>  misc_feature
<222>  (198)..(863)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta-actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1942)..(4479)
<223>  MR27HL-Fc1 decoy revised linker

<220>
<221>  misc_feature
<222>  (1942)..(3786)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (3793)..(4473)
<223>  IgG1Fc

<220>
<221>  polyA_signal
<222>  (4540)..(4666)
<223>  Rabbit globbin polyA

<220>
<221>  repeat_region
<222>  (4755)..(4884)
<223>  3'ITR

<400>  91
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcccgccac catgtcaagc tcttcctggc tccttctcag ccttgttgct     1980

gtaactgctg ctcagtccac cattgaggaa caggccaaga catttttgga catgtttaac     2040

cacaaagccg aagacctgtt ctatcaaagt tcacttgctt cttggaatta caacaccaat     2100

attactgaag agaatgtcca aaacatgaat aatgctgggg acaaatggtc tgccttttta     2160

aaggaacagt ccacacttgc ccaaatgtat ccactacaag aaattcagaa tcccacagtc     2220

aagcttcagc tgcaggctct tcagcaaaat gggtcttcag tgctctcaga agacaagagc     2280

aaacggttga acacaattct aaatacaatg agcaccatct acagtactgg aaaagtttgt     2340

aacccggata atccacaaga atgcttatta cttgaaccag gtttgaatga aataatggca     2400

aacagtttag actacaatga gaggctctgg gcttgggaaa gctggagatc tgaggtcggc     2460

aagcagctga ggccattata tgaagagtat gtggtcttga aaaatgagat ggcgagagca     2520

aaccattatg aggactatgg ggattattgg agaggagact atgaagtaaa tggggtagat     2580

ggctatgact acagccgcgg ccagttgatt gaagatgtgg aacatacctt tgaagagatt     2640

aaaccattat atgaacatct tcatgcctat gtgagggcaa agttgatgaa tgcctatcct     2700

tcctatatca gtccaattgg atgcctccct gctcatttgc ttggtgatat gtggggtaga     2760

ttttggacaa atctgtactc tttgacagtt cccttcggac agaaaccaaa catagatgtt     2820

actgatgcaa tggtggacca ggcctgggat gcacagagaa tattcaagga ggccgagaag     2880

ttctttgtat ctgttggtct tcctaatatg actcaaggat tctgggaata ttccatgcta     2940

acggacccag gaaatgttca gaaagcagtc tgccttccca cagcttggga cctggggaag     3000

ggcgacttca ggatccttat gtgcacaaag gtgacaatgg acgacttcct gacagctcat     3060

catgagatgg ggcatatcca gtatgatatg gcatatgctg cacaaccttt tctgctaaga     3120

aatggagcta atgaaggatt ccatgaagct gttggggaaa tcatgtcact ttctgcagcc     3180

acacctaagc atttaaaatc cattggtctt ctgtcacccg attttcaaga agacaatgaa     3240

acagaaataa acttcctgct caaacaagca ctcacgattg ttgggactct gccatttact     3300

tacatgttag agaagtggag gtggatggtc tttaaagggg aaattcccaa agaccagtgg     3360

atgaaaaagt ggtgggagat gaagcgagag atagttgggg tggtggaacc tgtgccccat     3420

gatgaaacat actgtgaccc cgcatctctg ttccatgttt ctaatgatta ctcattcatt     3480

cgatattaca caaggaccct ttaccaattc cagtttcaag aagcactttg tcaagcagct     3540

aaacatgaag gccctctgca caaatgtgac atctcaaact ctacagaagc tggacagaaa     3600

ctgttcaata tgctgaggct tggaaaatca gaaccctgga ccctagcatt ggaaaatgtt     3660

gtaggagcaa agaacatgaa tgtaaggcca ctgctcaact actttgagcc cttatttacc     3720

tggctgaaag accagaacaa gaattctttt gtgggatgga gtaccgactg gagtccatat     3780

gcagacggaa gtgacaagac ccacacctgt cctccatgtc ctgctccaga actgctcggc     3840

ggaccttccg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc     3900

cctgaagtga cctgcgtggt ggtggatgtg tcccacgagg atcccgaagt gaagttcaat     3960

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac     4020

aacagcacct acagagtggt gtccgtgctg accgtgctgc accaggattg gctgaacggc     4080

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg ctcctatcga gaaaaccatc     4140

agcaaggcca agggccagcc tagggaaccc caggtttaca cactgcctcc aagcagggac     4200

gagctgacca agaatcaggt gtccctgacc tgcctcgtga agggcttcta cccttccgat     4260

atcgccgtgg aatgggagag caacggccag cctgagaaca actacaagac aacccctcct     4320

gtgctggaca gcgacggctc attcttcctg tacagcaagc tgacagtgga caagtccagg     4380

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     4440

acccagaagt ccctgagcct gtctcctgga aaatgatgag gtacctctag agtcgacccg     4500

ggcggcctcg aggacggggt gaactacgcc tgaggatccg atctttttcc ctctgccaaa     4560

aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata aaggaaattt     4620

attttcattg caatagtgtg ttggaatttt ttgtgtctct cactcggaag caattcgttg     4680

atctgaattt cgaccaccca taatacccat taccctggta gataagtagc atggcgggtt     4740

aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4800

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4860

ctcagtgagc gagcgagcgc gcag                                            4884


<210>  92
<211>  4469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette comprising hAce2MR27HL-IgG1Fc decoy revised 
       linker


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE promoter/enhancer

<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (385)..(666)
<223>  CB promoter

<220>
<221>  Intron
<222>  (759)..(1731)
<223>  chicken beta actin intron (chimeric intron)

<220>
<221>  misc_feature
<222>  (1745)..(4282)
<223>  MR27HL-IgG1Fc decoy revised linker

<220>
<221>  misc_feature
<222>  (1745)..(3589)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (3596)..(4276)
<223>  IgG1Fc

<220>
<221>  polyA_signal
<222>  (4343)..(4469)
<223>  Rabbit globin polyA

<400>  92
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcccgc     1740

caccatgtca agctcttcct ggctccttct cagccttgtt gctgtaactg ctgctcagtc     1800

caccattgag gaacaggcca agacattttt ggacatgttt aaccacaaag ccgaagacct     1860

gttctatcaa agttcacttg cttcttggaa ttacaacacc aatattactg aagagaatgt     1920

ccaaaacatg aataatgctg gggacaaatg gtctgccttt ttaaaggaac agtccacact     1980

tgcccaaatg tatccactac aagaaattca gaatcccaca gtcaagcttc agctgcaggc     2040

tcttcagcaa aatgggtctt cagtgctctc agaagacaag agcaaacggt tgaacacaat     2100

tctaaataca atgagcacca tctacagtac tggaaaagtt tgtaacccgg ataatccaca     2160

agaatgctta ttacttgaac caggtttgaa tgaaataatg gcaaacagtt tagactacaa     2220

tgagaggctc tgggcttggg aaagctggag atctgaggtc ggcaagcagc tgaggccatt     2280

atatgaagag tatgtggtct tgaaaaatga gatggcgaga gcaaaccatt atgaggacta     2340

tggggattat tggagaggag actatgaagt aaatggggta gatggctatg actacagccg     2400

cggccagttg attgaagatg tggaacatac ctttgaagag attaaaccat tatatgaaca     2460

tcttcatgcc tatgtgaggg caaagttgat gaatgcctat ccttcctata tcagtccaat     2520

tggatgcctc cctgctcatt tgcttggtga tatgtggggt agattttgga caaatctgta     2580

ctctttgaca gttcccttcg gacagaaacc aaacatagat gttactgatg caatggtgga     2640

ccaggcctgg gatgcacaga gaatattcaa ggaggccgag aagttctttg tatctgttgg     2700

tcttcctaat atgactcaag gattctggga atattccatg ctaacggacc caggaaatgt     2760

tcagaaagca gtctgccttc ccacagcttg ggacctgggg aagggcgact tcaggatcct     2820

tatgtgcaca aaggtgacaa tggacgactt cctgacagct catcatgaga tggggcatat     2880

ccagtatgat atggcatatg ctgcacaacc ttttctgcta agaaatggag ctaatgaagg     2940

attccatgaa gctgttgggg aaatcatgtc actttctgca gccacaccta agcatttaaa     3000

atccattggt cttctgtcac ccgattttca agaagacaat gaaacagaaa taaacttcct     3060

gctcaaacaa gcactcacga ttgttgggac tctgccattt acttacatgt tagagaagtg     3120

gaggtggatg gtctttaaag gggaaattcc caaagaccag tggatgaaaa agtggtggga     3180

gatgaagcga gagatagttg gggtggtgga acctgtgccc catgatgaaa catactgtga     3240

ccccgcatct ctgttccatg tttctaatga ttactcattc attcgatatt acacaaggac     3300

cctttaccaa ttccagtttc aagaagcact ttgtcaagca gctaaacatg aaggccctct     3360

gcacaaatgt gacatctcaa actctacaga agctggacag aaactgttca atatgctgag     3420

gcttggaaaa tcagaaccct ggaccctagc attggaaaat gttgtaggag caaagaacat     3480

gaatgtaagg ccactgctca actactttga gcccttattt acctggctga aagaccagaa     3540

caagaattct tttgtgggat ggagtaccga ctggagtcca tatgcagacg gaagtgacaa     3600

gacccacacc tgtcctccat gtcctgctcc agaactgctc ggcggacctt ccgtgttcct     3660

gtttcctcca aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgcgt     3720

ggtggtggat gtgtcccacg aggatcccga agtgaagttc aattggtacg tggacggcgt     3780

ggaagtgcac aacgccaaga ccaagcctag agaggaacag tacaacagca cctacagagt     3840

ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac ggcaaagagt acaagtgcaa     3900

ggtgtccaac aaggccctgc ctgctcctat cgagaaaacc atcagcaagg ccaagggcca     3960

gcctagggaa ccccaggttt acacactgcc tccaagcagg gacgagctga ccaagaatca     4020

ggtgtccctg acctgcctcg tgaagggctt ctacccttcc gatatcgccg tggaatggga     4080

gagcaacggc cagcctgaga acaactacaa gacaacccct cctgtgctgg acagcgacgg     4140

ctcattcttc ctgtacagca agctgacagt ggacaagtcc aggtggcagc agggcaacgt     4200

gttcagctgc agcgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgag     4260

cctgtctcct ggaaaatgat gaggtacctc tagagtcgac ccgggcggcc tcgaggacgg     4320

ggtgaactac gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat     4380

gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt     4440

gtgttggaat tttttgtgtc tctcactcg                                       4469


<210>  93
<211>  2541
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2(variant 2)(GTP14HL)-IgG1Fc decoy


<220>
<221>  CDS
<222>  (1)..(2541)
<223>  hAce2(variant 2)(GTP14HL)-IgG1Fc

<220>
<221>  misc_feature
<222>  (1)..(1845)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  Ace2 signal peptide

<220>
<221>  misc_feature
<222>  (1846)..(2541)
<223>  IgG1Fc

<400>  93
atg tca agc tct tcc tgg ctc ctt ctc agc ctt gtt gct gta act gct         48
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala           
1               5                   10                  15                

gct cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt         96
Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe           
            20                  25                  30                    

aac cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct gct tgg        144
Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp           
        35                  40                  45                        

aat tat aac acc aat att act gaa gag aat gtc caa aac atg aat aac        192
Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn           
    50                  55                  60                            

gct ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ttt gcc        240
Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala           
65                  70                  75                  80            

caa atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag        288
Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln           
                85                  90                  95                

ctg cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag        336
Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys           
            100                 105                 110                   

agc aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt        384
Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser           
        115                 120                 125                       

act gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt        432
Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu           
    130                 135                 140                           

gaa cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag        480
Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu           
145                 150                 155                 160           

agg ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg        528
Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu           
                165                 170                 175               

agg cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga        576
Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg           
            180                 185                 190                   

gca aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa        624
Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu           
        195                 200                 205                       

gta aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa        672
Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu           
    210                 215                 220                           

gat gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt        720
Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu           
225                 230                 235                 240           

cat gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc        768
His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile           
                245                 250                 255               

agt cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt        816
Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly           
            260                 265                 270                   

aga ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa        864
Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys           
        275                 280                 285                       

cca aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca        912
Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala           
    290                 295                 300                           

cag aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt        960
Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu           
305                 310                 315                 320           

cct aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca       1008
Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro           
                325                 330                 335               

gga aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg       1056
Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly           
            340                 345                 350                   

aag ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac       1104
Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp           
        355                 360                 365                       

ttc ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca       1152
Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala           
    370                 375                 380                           

tat gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc       1200
Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe           
385                 390                 395                 400           

cat gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag       1248
His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys           
                405                 410                 415               

cat tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat       1296
His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn           
            420                 425                 430                   

gaa aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg       1344
Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly           
        435                 440                 445                       

act ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt       1392
Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe           
    450                 455                 460                           

aaa ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg       1440
Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met           
465                 470                 475                 480           

aag cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca       1488
Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr           
                485                 490                 495               

tac tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc       1536
Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe           
            500                 505                 510                   

att cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca       1584
Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala           
        515                 520                 525                       

ctt tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc       1632
Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile           
    530                 535                 540                           

tca aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt       1680
Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu           
545                 550                 555                 560           

gga aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca       1728
Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala           
                565                 570                 575               

aag aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt       1776
Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe           
            580                 585                 590                   

acc tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc       1824
Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr           
        595                 600                 605                       

gac tgg agt cca tat gca gac gaa ccc aag agc tgc gac aag acc cac       1872
Asp Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Cys Asp Lys Thr His           
    610                 615                 620                           

acc tgt cct cca tgt cct gct cca gaa ctg ctc ggc gga cct tcc gtg       1920
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val           
625                 630                 635                 640           

ttc ctg ttt cct cca aag cct aag gac acc ctg atg atc agc aga acc       1968
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr           
                645                 650                 655               

cct gaa gtg acc tgc gtg gtg gtg gat gtg tcc cac gag gat ccc gaa       2016
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu           
            660                 665                 670                   

gtg aag ttc aat tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag       2064
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys           
        675                 680                 685                       

acc aag cct aga gag gaa cag tac aac agc acc tac aga gtg gtg tcc       2112
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser           
    690                 695                 700                           

gtg ctg acc gtg ctg cac cag gat tgg ctg aac ggc aaa gag tac aag       2160
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys           
705                 710                 715                 720           

tgc aag gtg tcc aac aag gcc ctg cct gct cct atc gag aaa acc atc       2208
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile           
                725                 730                 735               

agc aag gcc aag ggc cag cct agg gaa ccc cag gtt tac aca ctg cct       2256
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro           
            740                 745                 750                   

cca agc agg gac gag ctg acc aag aat cag gtg tcc ctg acc tgc ctc       2304
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu           
        755                 760                 765                       

gtg aag ggc ttc tac cct tcc gat atc gcc gtg gaa tgg gag agc aac       2352
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn           
    770                 775                 780                           

ggc cag cct gag aac aac tac aag aca acc cct cct gtg ctg gac agc       2400
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser           
785                 790                 795                 800           

gac ggc tca ttc ttc ctg tac agc aag ctg aca gtg gac aag tcc agg       2448
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg           
                805                 810                 815               

tgg cag cag ggc aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg       2496
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu           
            820                 825                 830                   

cac aac cac tac acc cag aag tcc ctg agc ctg tct cct gga aaa           2541
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys               
        835                 840                 845                       


<210>  94
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  94

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Cys Asp Lys Thr His 
    610                 615                 620                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
625                 630                 635                 640 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                645                 650                 655     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            660                 665                 670         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        675                 680                 685             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    690                 695                 700                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
705                 710                 715                 720 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                725                 730                 735     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            740                 745                 750         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        755                 760                 765             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    770                 775                 780                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
785                 790                 795                 800 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                805                 810                 815     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            820                 825                 830         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840                 845         


<210>  95
<211>  2547
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   hAce2MR27HL-IgG1Fc decoy


<220>
<221>  CDS
<222>  (1)..(2547)
<223>  MR27HLFc1 decoy

<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  Ace2 signal peptide

<220>
<221>  misc_feature
<222>  (1)..(1845)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (1846)..(2541)
<223>  IgG1Fc

<400>  95
atg tca agc tct tcc tgg ctc ctt ctc agc ctt gtt gct gta act gct         48
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala           
1               5                   10                  15                

gct cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt         96
Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe           
            20                  25                  30                    

aac cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg        144
Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp           
        35                  40                  45                        

aat tac aac acc aat att act gaa gag aat gtc caa aac atg aat aat        192
Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn           
    50                  55                  60                            

gct ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc        240
Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala           
65                  70                  75                  80            

caa atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag        288
Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln           
                85                  90                  95                

ctg cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag        336
Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys           
            100                 105                 110                   

agc aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt        384
Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser           
        115                 120                 125                       

act gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt        432
Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu           
    130                 135                 140                           

gaa cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag        480
Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu           
145                 150                 155                 160           

agg ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg        528
Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu           
                165                 170                 175               

agg cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga        576
Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg           
            180                 185                 190                   

gca aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa        624
Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu           
        195                 200                 205                       

gta aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa        672
Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu           
    210                 215                 220                           

gat gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt        720
Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu           
225                 230                 235                 240           

cat gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc        768
His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile           
                245                 250                 255               

agt cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt        816
Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly           
            260                 265                 270                   

aga ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa        864
Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys           
        275                 280                 285                       

cca aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca        912
Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala           
    290                 295                 300                           

cag aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt        960
Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu           
305                 310                 315                 320           

cct aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca       1008
Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro           
                325                 330                 335               

gga aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg       1056
Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly           
            340                 345                 350                   

aag ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac       1104
Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp           
        355                 360                 365                       

ttc ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca       1152
Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala           
    370                 375                 380                           

tat gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc       1200
Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe           
385                 390                 395                 400           

cat gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag       1248
His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys           
                405                 410                 415               

cat tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat       1296
His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn           
            420                 425                 430                   

gaa aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg       1344
Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly           
        435                 440                 445                       

act ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt       1392
Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe           
    450                 455                 460                           

aaa ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg       1440
Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met           
465                 470                 475                 480           

aag cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca       1488
Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr           
                485                 490                 495               

tac tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc       1536
Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe           
            500                 505                 510                   

att cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca       1584
Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala           
        515                 520                 525                       

ctt tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc       1632
Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile           
    530                 535                 540                           

tca aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt       1680
Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu           
545                 550                 555                 560           

gga aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca       1728
Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala           
                565                 570                 575               

aag aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt       1776
Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe           
            580                 585                 590                   

acc tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc       1824
Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr           
        595                 600                 605                       

gac tgg agt cca tat gca gac gaa ccc aag agc tgc gac aag acc cac       1872
Asp Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Cys Asp Lys Thr His           
    610                 615                 620                           

acc tgt cct cca tgt cct gct cca gaa ctg ctc ggc gga cct tcc gtg       1920
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val           
625                 630                 635                 640           

ttc ctg ttt cct cca aag cct aag gac acc ctg atg atc agc aga acc       1968
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr           
                645                 650                 655               

cct gaa gtg acc tgc gtg gtg gtg gat gtg tcc cac gag gat ccc gaa       2016
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu           
            660                 665                 670                   

gtg aag ttc aat tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag       2064
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys           
        675                 680                 685                       

acc aag cct aga gag gaa cag tac aac agc acc tac aga gtg gtg tcc       2112
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser           
    690                 695                 700                           

gtg ctg acc gtg ctg cac cag gat tgg ctg aac ggc aaa gag tac aag       2160
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys           
705                 710                 715                 720           

tgc aag gtg tcc aac aag gcc ctg cct gct cct atc gag aaa acc atc       2208
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile           
                725                 730                 735               

agc aag gcc aag ggc cag cct agg gaa ccc cag gtt tac aca ctg cct       2256
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro           
            740                 745                 750                   

cca agc agg gac gag ctg acc aag aat cag gtg tcc ctg acc tgc ctc       2304
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu           
        755                 760                 765                       

gtg aag ggc ttc tac cct tcc gat atc gcc gtg gaa tgg gag agc aac       2352
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn           
    770                 775                 780                           

ggc cag cct gag aac aac tac aag aca acc cct cct gtg ctg gac agc       2400
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser           
785                 790                 795                 800           

gac ggc tca ttc ttc ctg tac agc aag ctg aca gtg gac aag tcc agg       2448
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg           
                805                 810                 815               

tgg cag cag ggc aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg       2496
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu           
            820                 825                 830                   

cac aac cac tac acc cag aag tcc ctg agc ctg tct cct gga aaa tga       2544
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys               
        835                 840                 845                       

tga                                                                   2547


<210>  96
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  96

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Cys Asp Lys Thr His 
    610                 615                 620                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
625                 630                 635                 640 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                645                 650                 655     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            660                 665                 670         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        675                 680                 685             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    690                 695                 700                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
705                 710                 715                 720 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                725                 730                 735     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            740                 745                 750         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        755                 760                 765             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    770                 775                 780                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
785                 790                 795                 800 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                805                 810                 815     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            820                 825                 830         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840                 845         


<210>  97
<211>  2538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2(variant 2)(GTP14HL)-IgG1Fc decoy  revised linker


<220>
<221>  CDS
<222>  (1)..(2538)
<223>  hAce2(variant 2)(GTP14HL)-IgG1 decoy revised linker

<220>
<221>  misc_feature
<222>  (1)..(1845)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (1852)..(2532)
<223>  IgGFc1

<400>  97
atg tca agc tct tcc tgg ctc ctt ctc agc ctt gtt gct gta act gct         48
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala           
1               5                   10                  15                

gct cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt         96
Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe           
            20                  25                  30                    

aac cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct gct tgg        144
Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp           
        35                  40                  45                        

aat tat aac acc aat att act gaa gag aat gtc caa aac atg aat aac        192
Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn           
    50                  55                  60                            

gct ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ttt gcc        240
Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala           
65                  70                  75                  80            

caa atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag        288
Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln           
                85                  90                  95                

ctg cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag        336
Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys           
            100                 105                 110                   

agc aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt        384
Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser           
        115                 120                 125                       

act gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt        432
Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu           
    130                 135                 140                           

gaa cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag        480
Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu           
145                 150                 155                 160           

agg ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg        528
Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu           
                165                 170                 175               

agg cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga        576
Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg           
            180                 185                 190                   

gca aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa        624
Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu           
        195                 200                 205                       

gta aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa        672
Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu           
    210                 215                 220                           

gat gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt        720
Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu           
225                 230                 235                 240           

cat gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc        768
His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile           
                245                 250                 255               

agt cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt        816
Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly           
            260                 265                 270                   

aga ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa        864
Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys           
        275                 280                 285                       

cca aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca        912
Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala           
    290                 295                 300                           

cag aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt        960
Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu           
305                 310                 315                 320           

cct aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca       1008
Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro           
                325                 330                 335               

gga aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg       1056
Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly           
            340                 345                 350                   

aag ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac       1104
Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp           
        355                 360                 365                       

ttc ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca       1152
Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala           
    370                 375                 380                           

tat gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc       1200
Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe           
385                 390                 395                 400           

cat gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag       1248
His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys           
                405                 410                 415               

cat tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat       1296
His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn           
            420                 425                 430                   

gaa aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg       1344
Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly           
        435                 440                 445                       

act ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt       1392
Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe           
    450                 455                 460                           

aaa ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg       1440
Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met           
465                 470                 475                 480           

aag cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca       1488
Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr           
                485                 490                 495               

tac tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc       1536
Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe           
            500                 505                 510                   

att cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca       1584
Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala           
        515                 520                 525                       

ctt tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc       1632
Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile           
    530                 535                 540                           

tca aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt       1680
Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu           
545                 550                 555                 560           

gga aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca       1728
Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala           
                565                 570                 575               

aag aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt       1776
Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe           
            580                 585                 590                   

acc tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc       1824
Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr           
        595                 600                 605                       

gac tgg agt cca tat gca gac gga agt gac aag acc cac acc tgt cct       1872
Asp Trp Ser Pro Tyr Ala Asp Gly Ser Asp Lys Thr His Thr Cys Pro           
    610                 615                 620                           

cca tgt cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt       1920
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe           
625                 630                 635                 640           

cct cca aag cct aag gac acc ctg atg atc agc aga acc cct gaa gtg       1968
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
                645                 650                 655               

acc tgc gtg gtg gtg gat gtg tcc cac gag gat ccc gaa gtg aag ttc       2016
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
            660                 665                 670                   

aat tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct       2064
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
        675                 680                 685                       

aga gag gaa cag tac aac agc acc tac aga gtg gtg tcc gtg ctg acc       2112
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
    690                 695                 700                           

gtg ctg cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg       2160
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
705                 710                 715                 720           

tcc aac aag gcc ctg cct gct cct atc gag aaa acc atc agc aag gcc       2208
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala           
                725                 730                 735               

aag ggc cag cct agg gaa ccc cag gtt tac aca ctg cct cca agc agg       2256
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
            740                 745                 750                   

gac gag ctg acc aag aat cag gtg tcc ctg acc tgc ctc gtg aag ggc       2304
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
        755                 760                 765                       

ttc tac cct tcc gat atc gcc gtg gaa tgg gag agc aac ggc cag cct       2352
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
    770                 775                 780                           

gag aac aac tac aag aca acc cct cct gtg ctg gac agc gac ggc tca       2400
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
785                 790                 795                 800           

ttc ttc ctg tac agc aag ctg aca gtg gac aag tcc agg tgg cag cag       2448
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
                805                 810                 815               

ggc aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg cac aac cac       2496
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
            820                 825                 830                   

tac acc cag aag tcc ctg agc ctg tct cct gga aaa tga tga               2538
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                           
        835                 840                                           


<210>  98
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  98

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gly Ser Asp Lys Thr His Thr Cys Pro 
    610                 615                 620                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            740                 745                 750         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840                 


<210>  99
<211>  2538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2MR27HL-IgG1Fc decoy revised linker


<220>
<221>  CDS
<222>  (1)..(2538)
<223>  MR27HL-IgG1Fc decoy revised linker

<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  Ace2 signal peptide

<220>
<221>  misc_feature
<222>  (1)..(1845)
<223>  Ace2

<220>
<221>  misc_feature
<222>  (1852)..(2532)
<223>  IgG1Fc

<400>  99
atg tca agc tct tcc tgg ctc ctt ctc agc ctt gtt gct gta act gct         48
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala           
1               5                   10                  15                

gct cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt         96
Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe           
            20                  25                  30                    

aac cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg        144
Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp           
        35                  40                  45                        

aat tac aac acc aat att act gaa gag aat gtc caa aac atg aat aat        192
Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn           
    50                  55                  60                            

gct ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc        240
Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala           
65                  70                  75                  80            

caa atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag        288
Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln           
                85                  90                  95                

ctg cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag        336
Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys           
            100                 105                 110                   

agc aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt        384
Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser           
        115                 120                 125                       

act gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt        432
Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu           
    130                 135                 140                           

gaa cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag        480
Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu           
145                 150                 155                 160           

agg ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg        528
Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu           
                165                 170                 175               

agg cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga        576
Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg           
            180                 185                 190                   

gca aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa        624
Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu           
        195                 200                 205                       

gta aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa        672
Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu           
    210                 215                 220                           

gat gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt        720
Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu           
225                 230                 235                 240           

cat gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc        768
His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile           
                245                 250                 255               

agt cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt        816
Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly           
            260                 265                 270                   

aga ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa        864
Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys           
        275                 280                 285                       

cca aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca        912
Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala           
    290                 295                 300                           

cag aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt        960
Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu           
305                 310                 315                 320           

cct aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca       1008
Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro           
                325                 330                 335               

gga aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg       1056
Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly           
            340                 345                 350                   

aag ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac       1104
Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp           
        355                 360                 365                       

ttc ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca       1152
Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala           
    370                 375                 380                           

tat gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc       1200
Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe           
385                 390                 395                 400           

cat gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag       1248
His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys           
                405                 410                 415               

cat tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat       1296
His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn           
            420                 425                 430                   

gaa aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg       1344
Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly           
        435                 440                 445                       

act ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt       1392
Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe           
    450                 455                 460                           

aaa ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg       1440
Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met           
465                 470                 475                 480           

aag cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca       1488
Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr           
                485                 490                 495               

tac tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc       1536
Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe           
            500                 505                 510                   

att cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca       1584
Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala           
        515                 520                 525                       

ctt tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc       1632
Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile           
    530                 535                 540                           

tca aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt       1680
Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu           
545                 550                 555                 560           

gga aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca       1728
Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala           
                565                 570                 575               

aag aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt       1776
Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe           
            580                 585                 590                   

acc tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc       1824
Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr           
        595                 600                 605                       

gac tgg agt cca tat gca gac gga agt gac aag acc cac acc tgt cct       1872
Asp Trp Ser Pro Tyr Ala Asp Gly Ser Asp Lys Thr His Thr Cys Pro           
    610                 615                 620                           

cca tgt cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt       1920
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe           
625                 630                 635                 640           

cct cca aag cct aag gac acc ctg atg atc agc aga acc cct gaa gtg       1968
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
                645                 650                 655               

acc tgc gtg gtg gtg gat gtg tcc cac gag gat ccc gaa gtg aag ttc       2016
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
            660                 665                 670                   

aat tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct       2064
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
        675                 680                 685                       

aga gag gaa cag tac aac agc acc tac aga gtg gtg tcc gtg ctg acc       2112
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
    690                 695                 700                           

gtg ctg cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg       2160
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
705                 710                 715                 720           

tcc aac aag gcc ctg cct gct cct atc gag aaa acc atc agc aag gcc       2208
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala           
                725                 730                 735               

aag ggc cag cct agg gaa ccc cag gtt tac aca ctg cct cca agc agg       2256
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
            740                 745                 750                   

gac gag ctg acc aag aat cag gtg tcc ctg acc tgc ctc gtg aag ggc       2304
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
        755                 760                 765                       

ttc tac cct tcc gat atc gcc gtg gaa tgg gag agc aac ggc cag cct       2352
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
    770                 775                 780                           

gag aac aac tac aag aca acc cct cct gtg ctg gac agc gac ggc tca       2400
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
785                 790                 795                 800           

ttc ttc ctg tac agc aag ctg aca gtg gac aag tcc agg tgg cag cag       2448
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
                805                 810                 815               

ggc aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg cac aac cac       2496
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
            820                 825                 830                   

tac acc cag aag tcc ctg agc ctg tct cct gga aaa tga tga               2538
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                           
        835                 840                                           


<210>  100
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gly Ser Asp Lys Thr His Thr Cys Pro 
    610                 615                 620                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            740                 745                 750         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840                 


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  101

Glu Pro Lys Ser Cys 
1               5   


<210>  102
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding IgG1 Fc


<220>
<221>  CDS
<222>  (1)..(696)
<223>  IgG1 Fc

<400>  102
gaa ccc aag agc tgc gac aag acc cac acc tgt cct cca tgt cct gct         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct cca aag cct         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctg atg atc agc aga acc cct gaa gtg acc tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gat gtg tcc cac gag gat ccc gaa gtg aag ttc aat tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga gag gaa cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acc tac aga gtg gtg tcc gtg ctg acc gtg ctg cac cag        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc aac aag gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctg cct gct cct atc gag aaa acc atc agc aag gcc aag ggc cag cct        384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

agg gaa ccc cag gtt tac aca ctg cct cca agc agg gac gag ctg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr           
    130                 135                 140                           

aag aat cag gtg tcc ctg acc tgc ctc gtg aag ggc ttc tac cct tcc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gat atc gcc gtg gaa tgg gag agc aac ggc cag cct gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

aag aca acc cct cct gtg ctg gac agc gac ggc tca ttc ttc ctg tac        576
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc aag ctg aca gtg gac aag tcc agg tgg cag cag ggc aac gtg ttc        624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

agc tgc agc gtg atg cac gag gcc ctg cac aac cac tac acc cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

tcc ctg agc ctg tct cct gga aaa                                        696
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  103
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  103

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  104
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucliec acid sequence encoding hAce2-MR27Variant


<220>
<221>  CDS
<222>  (1)..(1845)
<223>  hAce2-MR27Variant

<400>  104
atg tca agc tct tcc tgg ctc ctt ctc agc ctt gtt gct gta act gct         48
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala           
1               5                   10                  15                

gct cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt         96
Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe           
            20                  25                  30                    

aac cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg        144
Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp           
        35                  40                  45                        

aat tac aac acc aat att act gaa gag aat gtc caa aac atg aat aat        192
Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn           
    50                  55                  60                            

gct ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc        240
Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala           
65                  70                  75                  80            

caa atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag        288
Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln           
                85                  90                  95                

ctg cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag        336
Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys           
            100                 105                 110                   

agc aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt        384
Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser           
        115                 120                 125                       

act gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt        432
Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu           
    130                 135                 140                           

gaa cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag        480
Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu           
145                 150                 155                 160           

agg ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg        528
Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu           
                165                 170                 175               

agg cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga        576
Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg           
            180                 185                 190                   

gca aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa        624
Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu           
        195                 200                 205                       

gta aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa        672
Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu           
    210                 215                 220                           

gat gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt        720
Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu           
225                 230                 235                 240           

cat gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc        768
His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile           
                245                 250                 255               

agt cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt        816
Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly           
            260                 265                 270                   

aga ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa        864
Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys           
        275                 280                 285                       

cca aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca        912
Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala           
    290                 295                 300                           

cag aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt        960
Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu           
305                 310                 315                 320           

cct aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca       1008
Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro           
                325                 330                 335               

gga aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg       1056
Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly           
            340                 345                 350                   

aag ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac       1104
Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp           
        355                 360                 365                       

ttc ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca       1152
Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala           
    370                 375                 380                           

tat gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc       1200
Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe           
385                 390                 395                 400           

cat gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag       1248
His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys           
                405                 410                 415               

cat tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat       1296
His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn           
            420                 425                 430                   

gaa aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg       1344
Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly           
        435                 440                 445                       

act ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt       1392
Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe           
    450                 455                 460                           

aaa ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg       1440
Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met           
465                 470                 475                 480           

aag cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca       1488
Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr           
                485                 490                 495               

tac tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc       1536
Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe           
            500                 505                 510                   

att cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca       1584
Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala           
        515                 520                 525                       

ctt tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc       1632
Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile           
    530                 535                 540                           

tca aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt       1680
Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu           
545                 550                 555                 560           

gga aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca       1728
Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala           
                565                 570                 575               

aag aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt       1776
Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe           
            580                 585                 590                   

acc tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc       1824
Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr           
        595                 600                 605                       

gac tgg agt cca tat gca gac                                           1845
Asp Trp Ser Pro Tyr Ala Asp                                               
    610                 615                                               


<210>  105
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  105

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe 
            20                  25                  30          


Asn His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  106
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucliec acid sequence encoding hAce2-MR27Variant (without leader)


<220>
<221>  CDS
<222>  (1)..(1794)
<223>  hAce2-MR27Variant (without leader)

<400>  106
cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt aac         48
Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn           
1               5                   10                  15                

cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg aat         96
His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn           
            20                  25                  30                    

tac aac acc aat att act gaa gag aat gtc caa aac atg aat aat gct        144
Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala           
        35                  40                  45                        

ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc caa        192
Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln           
    50                  55                  60                            

atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag ctg        240
Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu           
65                  70                  75                  80            

cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag agc        288
Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser           
                85                  90                  95                

aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt act        336
Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr           
            100                 105                 110                   

gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt gaa        384
Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu           
        115                 120                 125                       

cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag agg        432
Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg           
    130                 135                 140                           

ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg agg        480
Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg           
145                 150                 155                 160           

cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga gca        528
Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala           
                165                 170                 175               

aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa gta        576
Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val           
            180                 185                 190                   

aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa gat        624
Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp           
        195                 200                 205                       

gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt cat        672
Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His           
    210                 215                 220                           

gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc agt        720
Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser           
225                 230                 235                 240           

cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt aga        768
Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg           
                245                 250                 255               

ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa cca        816
Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro           
            260                 265                 270                   

aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca cag        864
Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln           
        275                 280                 285                       

aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt cct        912
Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro           
    290                 295                 300                           

aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca gga        960
Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly           
305                 310                 315                 320           

aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg aag       1008
Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys           
                325                 330                 335               

ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac ttc       1056
Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe           
            340                 345                 350                   

ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca tat       1104
Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr           
        355                 360                 365                       

gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc cat       1152
Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His           
    370                 375                 380                           

gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag cat       1200
Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His           
385                 390                 395                 400           

tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat gaa       1248
Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu           
                405                 410                 415               

aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg act       1296
Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr           
            420                 425                 430                   

ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt aaa       1344
Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys           
        435                 440                 445                       

ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg aag       1392
Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys           
    450                 455                 460                           

cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca tac       1440
Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr           
465                 470                 475                 480           

tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc att       1488
Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile           
                485                 490                 495               

cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca ctt       1536
Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu           
            500                 505                 510                   

tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc tca       1584
Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser           
        515                 520                 525                       

aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt gga       1632
Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly           
    530                 535                 540                           

aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca aag       1680
Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys           
545                 550                 555                 560           

aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt acc       1728
Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr           
                565                 570                 575               

tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc gac       1776
Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp           
            580                 585                 590                   

tgg agt cca tat gca gac                                               1794
Trp Ser Pro Tyr Ala Asp                                                   
        595                                                               


<210>  107
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  107

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  108
<211>  2496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-Variant2-IgG1Fc decoy (without signal/leader peptide)


<220>
<221>  misc_feature
<222>  (1)..(1794)
<223>  hAce2 Variant 2  (without signal/leader peptide)

<220>
<221>  CDS
<222>  (1)..(2496)
<223>  hAce2-Variant 2-IgG1-Fc (without signal/leader peptide)

<220>
<221>  misc_feature
<222>  (1795)..(1809)
<223>  Linker

<220>
<221>  misc_feature
<222>  (1810)..(2490)
<223>  IgG1 Fc

<400>  108
cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt aac         48
Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn           
1               5                   10                  15                

cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct gct tgg aat         96
His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp Asn           
            20                  25                  30                    

tat aac acc aat att act gaa gag aat gtc caa aac atg aat aac gct        144
Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala           
        35                  40                  45                        

ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ttt gcc caa        192
Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln           
    50                  55                  60                            

atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag ctg        240
Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu           
65                  70                  75                  80            

cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag agc        288
Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser           
                85                  90                  95                

aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt act        336
Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr           
            100                 105                 110                   

gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt gaa        384
Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu           
        115                 120                 125                       

cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag agg        432
Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg           
    130                 135                 140                           

ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg agg        480
Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg           
145                 150                 155                 160           

cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga gca        528
Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala           
                165                 170                 175               

aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa gta        576
Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val           
            180                 185                 190                   

aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa gat        624
Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp           
        195                 200                 205                       

gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt cat        672
Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His           
    210                 215                 220                           

gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc agt        720
Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser           
225                 230                 235                 240           

cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt aga        768
Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg           
                245                 250                 255               

ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa cca        816
Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro           
            260                 265                 270                   

aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca cag        864
Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln           
        275                 280                 285                       

aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt cct        912
Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro           
    290                 295                 300                           

aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca gga        960
Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly           
305                 310                 315                 320           

aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg aag       1008
Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys           
                325                 330                 335               

ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac ttc       1056
Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe           
            340                 345                 350                   

ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca tat       1104
Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr           
        355                 360                 365                       

gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc cat       1152
Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His           
    370                 375                 380                           

gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag cat       1200
Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His           
385                 390                 395                 400           

tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat gaa       1248
Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu           
                405                 410                 415               

aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg act       1296
Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr           
            420                 425                 430                   

ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt aaa       1344
Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys           
        435                 440                 445                       

ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg aag       1392
Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys           
    450                 455                 460                           

cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca tac       1440
Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr           
465                 470                 475                 480           

tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc att       1488
Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile           
                485                 490                 495               

cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca ctt       1536
Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu           
            500                 505                 510                   

tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc tca       1584
Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser           
        515                 520                 525                       

aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt gga       1632
Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly           
    530                 535                 540                           

aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca aag       1680
Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys           
545                 550                 555                 560           

aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt acc       1728
Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr           
                565                 570                 575               

tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc gac       1776
Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp           
            580                 585                 590                   

tgg agt cca tat gca gac gaa ccc aag agc tgc gac aag acc cac acc       1824
Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr           
        595                 600                 605                       

tgt cct cca tgt cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc       1872
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe           
    610                 615                 620                           

ctg ttt cct cca aag cct aag gac acc ctg atg atc agc aga acc cct       1920
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro           
625                 630                 635                 640           

gaa gtg acc tgc gtg gtg gtg gat gtg tcc cac gag gat ccc gaa gtg       1968
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val           
                645                 650                 655               

aag ttc aat tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc       2016
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr           
            660                 665                 670                   

aag cct aga gag gaa cag tac aac agc acc tac aga gtg gtg tcc gtg       2064
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val           
        675                 680                 685                       

ctg acc gtg ctg cac cag gat tgg ctg aac ggc aaa gag tac aag tgc       2112
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys           
    690                 695                 700                           

aag gtg tcc aac aag gcc ctg cct gct cct atc gag aaa acc atc agc       2160
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser           
705                 710                 715                 720           

aag gcc aag ggc cag cct agg gaa ccc cag gtt tac aca ctg cct cca       2208
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro           
                725                 730                 735               

agc agg gac gag ctg acc aag aat cag gtg tcc ctg acc tgc ctc gtg       2256
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val           
            740                 745                 750                   

aag ggc ttc tac cct tcc gat atc gcc gtg gaa tgg gag agc aac ggc       2304
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly           
        755                 760                 765                       

cag cct gag aac aac tac aag aca acc cct cct gtg ctg gac agc gac       2352
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp           
    770                 775                 780                           

ggc tca ttc ttc ctg tac agc aag ctg aca gtg gac aag tcc agg tgg       2400
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp           
785                 790                 795                 800           

cag cag ggc aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg cac       2448
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His           
                805                 810                 815               

aac cac tac acc cag aag tcc ctg agc ctg tct cct gga aaa tga tga       2496
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                   
            820                 825                 830                   


<210>  109
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  109

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        595                 600                 605             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    610                 615                 620                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
625                 630                 635                 640 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                645                 650                 655     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            660                 665                 670         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        675                 680                 685             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    690                 695                 700                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
705                 710                 715                 720 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                725                 730                 735     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            740                 745                 750         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        755                 760                 765             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    770                 775                 780                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
785                 790                 795                 800 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                805                 810                 815     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            820                 825                 830 


<210>  110
<211>  2496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-MR27HL-Variant-IgG1Fc decoy (without signal/leader peptide)


<220>
<221>  misc_feature
<222>  (1)..(1794)
<223>  hAce2-MR27HL-Variant

<220>
<221>  CDS
<222>  (1)..(2496)
<223>  hAce2-MR27HL-Variant-IgG1-Fc

<220>
<221>  misc_feature
<222>  (1795)..(1809)
<223>  linker

<220>
<221>  misc_feature
<222>  (1810)..(2490)
<223>  IgG1 Fc

<400>  110
cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt aac         48
Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn           
1               5                   10                  15                

cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg aat         96
His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn           
            20                  25                  30                    

tac aac acc aat att act gaa gag aat gtc caa aac atg aat aat gct        144
Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala           
        35                  40                  45                        

ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc caa        192
Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln           
    50                  55                  60                            

atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag ctg        240
Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu           
65                  70                  75                  80            

cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag agc        288
Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser           
                85                  90                  95                

aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt act        336
Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr           
            100                 105                 110                   

gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt gaa        384
Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu           
        115                 120                 125                       

cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag agg        432
Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg           
    130                 135                 140                           

ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg agg        480
Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg           
145                 150                 155                 160           

cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga gca        528
Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala           
                165                 170                 175               

aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa gta        576
Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val           
            180                 185                 190                   

aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa gat        624
Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp           
        195                 200                 205                       

gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt cat        672
Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His           
    210                 215                 220                           

gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc agt        720
Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser           
225                 230                 235                 240           

cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt aga        768
Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg           
                245                 250                 255               

ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa cca        816
Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro           
            260                 265                 270                   

aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca cag        864
Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln           
        275                 280                 285                       

aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt cct        912
Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro           
    290                 295                 300                           

aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca gga        960
Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly           
305                 310                 315                 320           

aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg aag       1008
Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys           
                325                 330                 335               

ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac ttc       1056
Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe           
            340                 345                 350                   

ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca tat       1104
Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr           
        355                 360                 365                       

gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc cat       1152
Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His           
    370                 375                 380                           

gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag cat       1200
Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His           
385                 390                 395                 400           

tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat gaa       1248
Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu           
                405                 410                 415               

aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg act       1296
Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr           
            420                 425                 430                   

ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt aaa       1344
Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys           
        435                 440                 445                       

ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg aag       1392
Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys           
    450                 455                 460                           

cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca tac       1440
Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr           
465                 470                 475                 480           

tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc att       1488
Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile           
                485                 490                 495               

cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca ctt       1536
Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu           
            500                 505                 510                   

tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc tca       1584
Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser           
        515                 520                 525                       

aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt gga       1632
Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly           
    530                 535                 540                           

aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca aag       1680
Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys           
545                 550                 555                 560           

aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt acc       1728
Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr           
                565                 570                 575               

tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc gac       1776
Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp           
            580                 585                 590                   

tgg agt cca tat gca gac gaa ccc aag agc tgc gac aag acc cac acc       1824
Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr           
        595                 600                 605                       

tgt cct cca tgt cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc       1872
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe           
    610                 615                 620                           

ctg ttt cct cca aag cct aag gac acc ctg atg atc agc aga acc cct       1920
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro           
625                 630                 635                 640           

gaa gtg acc tgc gtg gtg gtg gat gtg tcc cac gag gat ccc gaa gtg       1968
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val           
                645                 650                 655               

aag ttc aat tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc       2016
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr           
            660                 665                 670                   

aag cct aga gag gaa cag tac aac agc acc tac aga gtg gtg tcc gtg       2064
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val           
        675                 680                 685                       

ctg acc gtg ctg cac cag gat tgg ctg aac ggc aaa gag tac aag tgc       2112
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys           
    690                 695                 700                           

aag gtg tcc aac aag gcc ctg cct gct cct atc gag aaa acc atc agc       2160
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser           
705                 710                 715                 720           

aag gcc aag ggc cag cct agg gaa ccc cag gtt tac aca ctg cct cca       2208
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro           
                725                 730                 735               

agc agg gac gag ctg acc aag aat cag gtg tcc ctg acc tgc ctc gtg       2256
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val           
            740                 745                 750                   

aag ggc ttc tac cct tcc gat atc gcc gtg gaa tgg gag agc aac ggc       2304
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly           
        755                 760                 765                       

cag cct gag aac aac tac aag aca acc cct cct gtg ctg gac agc gac       2352
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp           
    770                 775                 780                           

ggc tca ttc ttc ctg tac agc aag ctg aca gtg gac aag tcc agg tgg       2400
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp           
785                 790                 795                 800           

cag cag ggc aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg cac       2448
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His           
                805                 810                 815               

aac cac tac acc cag aag tcc ctg agc ctg tct cct gga aaa tga tga       2496
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                   
            820                 825                 830                   


<210>  111
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  111

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        595                 600                 605             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    610                 615                 620                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
625                 630                 635                 640 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                645                 650                 655     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            660                 665                 670         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        675                 680                 685             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    690                 695                 700                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
705                 710                 715                 720 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                725                 730                 735     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            740                 745                 750         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        755                 760                 765             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    770                 775                 780                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
785                 790                 795                 800 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                805                 810                 815     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            820                 825                 830 


<210>  112
<211>  2487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-Variant2-IgG1Fc decoy (without signal/leader peptide; 
       revised linker)


<220>
<221>  CDS
<222>  (1)..(2487)
<223>  hAce2-Variant2-IgG1-Fc (revised linker; without leader/signal 
       peptide)

<220>
<221>  misc_feature
<222>  (1)..(1794)
<223>  hAce2-Variant 2

<220>
<221>  misc_feature
<222>  (1795)..(1800)
<223>  linker

<220>
<221>  misc_feature
<222>  (1801)..(2481)
<223>  IgG1-Fc

<400>  112
cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt aac         48
Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn           
1               5                   10                  15                

cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct gct tgg aat         96
His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp Asn           
            20                  25                  30                    

tat aac acc aat att act gaa gag aat gtc caa aac atg aat aac gct        144
Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala           
        35                  40                  45                        

ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ttt gcc caa        192
Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln           
    50                  55                  60                            

atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag ctg        240
Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu           
65                  70                  75                  80            

cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag agc        288
Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser           
                85                  90                  95                

aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt act        336
Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr           
            100                 105                 110                   

gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt gaa        384
Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu           
        115                 120                 125                       

cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag agg        432
Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg           
    130                 135                 140                           

ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg agg        480
Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg           
145                 150                 155                 160           

cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga gca        528
Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala           
                165                 170                 175               

aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa gta        576
Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val           
            180                 185                 190                   

aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa gat        624
Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp           
        195                 200                 205                       

gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt cat        672
Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His           
    210                 215                 220                           

gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc agt        720
Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser           
225                 230                 235                 240           

cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt aga        768
Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg           
                245                 250                 255               

ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa cca        816
Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro           
            260                 265                 270                   

aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca cag        864
Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln           
        275                 280                 285                       

aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt cct        912
Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro           
    290                 295                 300                           

aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca gga        960
Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly           
305                 310                 315                 320           

aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg aag       1008
Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys           
                325                 330                 335               

ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac ttc       1056
Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe           
            340                 345                 350                   

ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca tat       1104
Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr           
        355                 360                 365                       

gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc cat       1152
Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His           
    370                 375                 380                           

gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag cat       1200
Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His           
385                 390                 395                 400           

tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat gaa       1248
Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu           
                405                 410                 415               

aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg act       1296
Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr           
            420                 425                 430                   

ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt aaa       1344
Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys           
        435                 440                 445                       

ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg aag       1392
Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys           
    450                 455                 460                           

cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca tac       1440
Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr           
465                 470                 475                 480           

tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc att       1488
Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile           
                485                 490                 495               

cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca ctt       1536
Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu           
            500                 505                 510                   

tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc tca       1584
Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser           
        515                 520                 525                       

aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt gga       1632
Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly           
    530                 535                 540                           

aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca aag       1680
Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys           
545                 550                 555                 560           

aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt acc       1728
Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr           
                565                 570                 575               

tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc gac       1776
Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp           
            580                 585                 590                   

tgg agt cca tat gca gac gga agt gac aag acc cac acc tgt cct cca       1824
Trp Ser Pro Tyr Ala Asp Gly Ser Asp Lys Thr His Thr Cys Pro Pro           
        595                 600                 605                       

tgt cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct       1872
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro           
    610                 615                 620                           

cca aag cct aag gac acc ctg atg atc agc aga acc cct gaa gtg acc       1920
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr           
625                 630                 635                 640           

tgc gtg gtg gtg gat gtg tcc cac gag gat ccc gaa gtg aag ttc aat       1968
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn           
                645                 650                 655               

tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga       2016
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg           
            660                 665                 670                   

gag gaa cag tac aac agc acc tac aga gtg gtg tcc gtg ctg acc gtg       2064
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val           
        675                 680                 685                       

ctg cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc       2112
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser           
    690                 695                 700                           

aac aag gcc ctg cct gct cct atc gag aaa acc atc agc aag gcc aag       2160
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys           
705                 710                 715                 720           

ggc cag cct agg gaa ccc cag gtt tac aca ctg cct cca agc agg gac       2208
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp           
                725                 730                 735               

gag ctg acc aag aat cag gtg tcc ctg acc tgc ctc gtg aag ggc ttc       2256
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe           
            740                 745                 750                   

tac cct tcc gat atc gcc gtg gaa tgg gag agc aac ggc cag cct gag       2304
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu           
        755                 760                 765                       

aac aac tac aag aca acc cct cct gtg ctg gac agc gac ggc tca ttc       2352
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe           
    770                 775                 780                           

ttc ctg tac agc aag ctg aca gtg gac aag tcc agg tgg cag cag ggc       2400
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly           
785                 790                 795                 800           

aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg cac aac cac tac       2448
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr           
                805                 810                 815               

acc cag aag tcc ctg agc ctg tct cct gga aaa tga tga                   2487
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                               
            820                 825                                       


<210>  113
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  113

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ala Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Phe Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
        595                 600                 605             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    610                 615                 620                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
625                 630                 635                 640 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                645                 650                 655     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            660                 665                 670         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        675                 680                 685             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    690                 695                 700                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
705                 710                 715                 720 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                725                 730                 735     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            740                 745                 750         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        755                 760                 765             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    770                 775                 780                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
785                 790                 795                 800 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                805                 810                 815     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            820                 825         


<210>  114
<211>  2487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAce2-MR27HL-Variant-IgG1Fc decoy (without signal/leader peptide;
       revised linker)


<220>
<221>  CDS
<222>  (1)..(2487)
<223>  hAce2-MR27-Varisant-IgG1-Fc (without signal/leader peptide; 
       revised linker)

<220>
<221>  misc_feature
<222>  (1)..(1794)
<223>  hAce2-MR27 Variant

<220>
<221>  misc_feature
<222>  (1795)..(1800)
<223>  linker

<220>
<221>  misc_feature
<222>  (1801)..(2481)
<223>  IgG1 Fc

<400>  114
cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac atg ttt aac         48
Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn           
1               5                   10                  15                

cac aaa gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg aat         96
His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn           
            20                  25                  30                    

tac aac acc aat att act gaa gag aat gtc caa aac atg aat aat gct        144
Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala           
        35                  40                  45                        

ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc caa        192
Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln           
    50                  55                  60                            

atg tat cca cta caa gaa att cag aat ccc aca gtc aag ctt cag ctg        240
Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu           
65                  70                  75                  80            

cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag agc        288
Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser           
                85                  90                  95                

aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt act        336
Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr           
            100                 105                 110                   

gga aaa gtt tgt aac ccg gat aat cca caa gaa tgc tta tta ctt gaa        384
Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu           
        115                 120                 125                       

cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag agg        432
Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg           
    130                 135                 140                           

ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg agg        480
Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg           
145                 150                 155                 160           

cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gcg aga gca        528
Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala           
                165                 170                 175               

aac cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa gta        576
Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val           
            180                 185                 190                   

aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa gat        624
Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp           
        195                 200                 205                       

gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt cat        672
Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His           
    210                 215                 220                           

gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc agt        720
Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser           
225                 230                 235                 240           

cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt aga        768
Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg           
                245                 250                 255               

ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttc gga cag aaa cca        816
Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro           
            260                 265                 270                   

aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca cag        864
Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln           
        275                 280                 285                       

aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt cct        912
Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro           
    290                 295                 300                           

aat atg act caa gga ttc tgg gaa tat tcc atg cta acg gac cca gga        960
Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly           
305                 310                 315                 320           

aat gtt cag aaa gca gtc tgc ctt ccc aca gct tgg gac ctg ggg aag       1008
Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys           
                325                 330                 335               

ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac ttc       1056
Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe           
            340                 345                 350                   

ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca tat       1104
Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr           
        355                 360                 365                       

gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc cat       1152
Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His           
    370                 375                 380                           

gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag cat       1200
Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His           
385                 390                 395                 400           

tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat gaa       1248
Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu           
                405                 410                 415               

aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg act       1296
Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr           
            420                 425                 430                   

ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt aaa       1344
Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys           
        435                 440                 445                       

ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg aag       1392
Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys           
    450                 455                 460                           

cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca tac       1440
Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr           
465                 470                 475                 480           

tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc att       1488
Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile           
                485                 490                 495               

cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca ctt       1536
Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu           
            500                 505                 510                   

tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc tca       1584
Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser           
        515                 520                 525                       

aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt gga       1632
Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly           
    530                 535                 540                           

aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca aag       1680
Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys           
545                 550                 555                 560           

aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt acc       1728
Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr           
                565                 570                 575               

tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc gac       1776
Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp           
            580                 585                 590                   

tgg agt cca tat gca gac gga agt gac aag acc cac acc tgt cct cca       1824
Trp Ser Pro Tyr Ala Asp Gly Ser Asp Lys Thr His Thr Cys Pro Pro           
        595                 600                 605                       

tgt cct gct cca gaa ctg ctc ggc gga cct tcc gtg ttc ctg ttt cct       1872
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro           
    610                 615                 620                           

cca aag cct aag gac acc ctg atg atc agc aga acc cct gaa gtg acc       1920
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr           
625                 630                 635                 640           

tgc gtg gtg gtg gat gtg tcc cac gag gat ccc gaa gtg aag ttc aat       1968
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn           
                645                 650                 655               

tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag cct aga       2016
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg           
            660                 665                 670                   

gag gaa cag tac aac agc acc tac aga gtg gtg tcc gtg ctg acc gtg       2064
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val           
        675                 680                 685                       

ctg cac cag gat tgg ctg aac ggc aaa gag tac aag tgc aag gtg tcc       2112
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser           
    690                 695                 700                           

aac aag gcc ctg cct gct cct atc gag aaa acc atc agc aag gcc aag       2160
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys           
705                 710                 715                 720           

ggc cag cct agg gaa ccc cag gtt tac aca ctg cct cca agc agg gac       2208
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp           
                725                 730                 735               

gag ctg acc aag aat cag gtg tcc ctg acc tgc ctc gtg aag ggc ttc       2256
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe           
            740                 745                 750                   

tac cct tcc gat atc gcc gtg gaa tgg gag agc aac ggc cag cct gag       2304
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu           
        755                 760                 765                       

aac aac tac aag aca acc cct cct gtg ctg gac agc gac ggc tca ttc       2352
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe           
    770                 775                 780                           

ttc ctg tac agc aag ctg aca gtg gac aag tcc agg tgg cag cag ggc       2400
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly           
785                 790                 795                 800           

aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg cac aac cac tac       2448
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr           
                805                 810                 815               

acc cag aag tcc ctg agc ctg tct cct gga aaa tga tga                   2487
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                               
            820                 825                                       


<210>  115
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  115

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Met Phe Asn 
1               5                   10                  15      


His Lys Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Pro Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Tyr Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys Leu Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
        595                 600                 605             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    610                 615                 620                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
625                 630                 635                 640 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                645                 650                 655     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            660                 665                 670         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        675                 680                 685             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    690                 695                 700                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
705                 710                 715                 720 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                725                 730                 735     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            740                 745                 750         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        755                 760                 765             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    770                 775                 780                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
785                 790                 795                 800 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                805                 810                 815     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            820                 825         


<210>  116
<211>  4469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette cb7-ci-hace2gtp14-fc4-rbg


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE enhancer

<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (385)..(666)
<223>  CB promoter

<220>
<221>  Intron
<222>  (759)..(1731)
<223>  chicken beta actin intron

<220>
<221>  misc_feature
<222>  (1745)..(1795)
<223>  Ace2 signal peptide

<220>
<221>  misc_feature
<222>  (1745)..(3589)
<223>  hAce2 (variant 1) (GTP14)

<220>
<221>  misc_feature
<222>  (1745)..(4276)
<223>  hAce2(Variant 1)(GTP14)-IgG4

<220>
<221>  misc_feature
<222>  (3590)..(4276)
<223>  human IgG4 Fc

<220>
<221>  polyA_signal
<222>  (4343)..(4469)
<223>  rabbit beta globin polyA

<400>  116
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcccgc     1740

caccatgtca agctcttcct ggctccttct cagccttgtt gctgtaactg ctgctcagtc     1800

caccattgag gaacaggcca agacattttt ggacatgttt aaccacaaag ccgaagacct     1860

gttctatcaa agttcacttg ctgcttggaa ttataacacc aatattactg aagagaatgt     1920

ccaaaacatg aataacgctg gggacaaatg gtctgccttt ttaaaggaac agtccacatt     1980

tgcccaaatg tatccactac aagaaattca gaatcccaca gtcaagcttc agctgcaggc     2040

tcttcagcaa aatgggtctt cagtgctctc agaagacaag agcaaacggt tgaacacaat     2100

tctaaataca atgagcacca tctacagtac tggaaaagtt tgtaacccgg ataatccaca     2160

agaatgctta ttacttgaac caggtttgaa tgaaataatg gcaaacagtt tagactacaa     2220

tgagaggctc tgggcttggg aaagctggag atctgaggtc ggcaagcagc tgaggccatt     2280

atatgaagag tatgtggtct tgaaaaatga gatggcgaga gcaaaccatt atgaggacta     2340

tggggattat tggagaggag actatgaagt aaatggggta gatggctatg actacagccg     2400

cggccagttg attgaagatg tggaacatac ctttgaagag attaaaccat tatatgaaca     2460

tcttcatgcc tatgtgaggg caaagttgat gaatgcctat ccttcctata tcagtccaat     2520

tggatgcctc cctgctcatt tgcttggtga tatgtggggt agattttgga caaatctgta     2580

ctctttgaca gttcccttcg gacagaaacc aaacatagat gttactgatg caatggtgga     2640

ccaggcctgg gatgcacaga gaatattcaa ggaggccgag aagttctttg tatctgttgg     2700

tcttcctaat atgactcaag gattctggga atattccatg ctaacggacc caggaaatgt     2760

tcagaaagca gtctgccatc ccacagcttg ggacctgggg aagggcgact tcaggatcct     2820

tatgtgcaca aaggtgacaa tggacgactt cctgacagct catcatgaga tggggcatat     2880

ccagtatgat atggcatatg ctgcacaacc ttttctgcta agaaatggag ctaatgaagg     2940

attccatgaa gctgttgggg aaatcatgtc actttctgca gccacaccta agcatttaaa     3000

atccattggt cttctgtcac ccgattttca agaagacaat gaaacagaaa taaacttcct     3060

gctcaaacaa gcactcacga ttgttgggac tctgccattt acttacatgt tagagaagtg     3120

gaggtggatg gtctttaaag gggaaattcc caaagaccag tggatgaaaa agtggtggga     3180

gatgaagcga gagatagttg gggtggtgga acctgtgccc catgatgaaa catactgtga     3240

ccccgcatct ctgttccatg tttctaatga ttactcattc attcgatatt acacaaggac     3300

cctttaccaa ttccagtttc aagaagcact ttgtcaagca gctaaacatg aaggccctct     3360

gcacaaatgt gacatctcaa actctacaga agctggacag aaactgttca atatgctgag     3420

gcttggaaaa tcagaaccct ggaccctagc attggaaaat gttgtaggag caaagaacat     3480

gaatgtaagg ccactgctca actactttga gcccttattt acctggctga aagaccagaa     3540

caagaattct tttgtgggat ggagtaccga ctggagtcca tatgcagacg agtctaagta     3600

cggccctcct tgtccttcct gccccgctcc tgaatttctc ggcggacctt ccgtgttcct     3660

gtttcctcca aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgcgt     3720

ggtggtggac gtgtcccaag aggatcctga ggtgcagttc aattggtacg tcgacggcgt     3780

ggaagtgcac aacgccaaga ccaagcctag agaggaacag ttcaacagca cctacagagt     3840

ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac ggcaaagagt acaagtgcaa     3900

ggtgtccaac aagggcctgc caagcagcat cgagaaaacc atcagcaagg ccaagggcca     3960

gcctagggaa ccccaggttt acacactgcc tccaagccaa gaggaaatga ccaagaacca     4020

ggtgtccctg acctgcctgg tcaagggctt ctacccttcc gatatcgccg tggaatggga     4080

gagcaacggc cagcctgaga acaactacaa gaccacacct cctgtgctgg acagcgacgg     4140

ctcattcttc ctgtactccc ggctgaccgt ggacaagtcc agatggcaag agggcaacgt     4200

gttcagctgc agcgtgatgc acgaggccct gcacaatcac tacacccaga agtccctgag     4260

tctgagcctg ggcaagtgat gaggtacctc tagagtcgac ccgggcggcc tcgaggacgg     4320

ggtgaactac gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat     4380

gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt     4440

gtgttggaat tttttgtgtc tctcactcg                                       4469


<210>  117
<211>  4469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette cb7-ci-hace2gtp14hl-fc4-rbg


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE Enhancer

<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (385)..(666)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (1745)..(4276)
<223>  hAce2(variant 2)(GTP14HL)-IgG4

<220>
<221>  misc_feature
<222>  (1745)..(1795)
<223>  ACE2 signaling peptide

<220>
<221>  misc_feature
<222>  (1745)..(3589)
<223>  hAce(variant 2)(GTP14HL)

<220>
<221>  misc_feature
<222>  (3590)..(4276)
<223>  Human IgG4 Fc

<220>
<221>  polyA_signal
<222>  (4343)..(4469)
<223>  Rabbit beta globin polyA

<400>  117
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcccgc     1740

caccatgtca agctcttcct ggctccttct cagccttgtt gctgtaactg ctgctcagtc     1800

caccattgag gaacaggcca agacattttt ggacatgttt aaccacaaag ccgaagacct     1860

gttctatcaa agttcacttg ctgcttggaa ttataacacc aatattactg aagagaatgt     1920

ccaaaacatg aataacgctg gggacaaatg gtctgccttt ttaaaggaac agtccacatt     1980

tgcccaaatg tatccactac aagaaattca gaatcccaca gtcaagcttc agctgcaggc     2040

tcttcagcaa aatgggtctt cagtgctctc agaagacaag agcaaacggt tgaacacaat     2100

tctaaataca atgagcacca tctacagtac tggaaaagtt tgtaacccgg ataatccaca     2160

agaatgctta ttacttgaac caggtttgaa tgaaataatg gcaaacagtt tagactacaa     2220

tgagaggctc tgggcttggg aaagctggag atctgaggtc ggcaagcagc tgaggccatt     2280

atatgaagag tatgtggtct tgaaaaatga gatggcgaga gcaaaccatt atgaggacta     2340

tggggattat tggagaggag actatgaagt aaatggggta gatggctatg actacagccg     2400

cggccagttg attgaagatg tggaacatac ctttgaagag attaaaccat tatatgaaca     2460

tcttcatgcc tatgtgaggg caaagttgat gaatgcctat ccttcctata tcagtccaat     2520

tggatgcctc cctgctcatt tgcttggtga tatgtggggt agattttgga caaatctgta     2580

ctctttgaca gttcccttcg gacagaaacc aaacatagat gttactgatg caatggtgga     2640

ccaggcctgg gatgcacaga gaatattcaa ggaggccgag aagttctttg tatctgttgg     2700

tcttcctaat atgactcaag gattctggga atattccatg ctaacggacc caggaaatgt     2760

tcagaaagca gtctgccttc ccacagcttg ggacctgggg aagggcgact tcaggatcct     2820

tatgtgcaca aaggtgacaa tggacgactt cctgacagct catcatgaga tggggcatat     2880

ccagtatgat atggcatatg ctgcacaacc ttttctgcta agaaatggag ctaatgaagg     2940

attccatgaa gctgttgggg aaatcatgtc actttctgca gccacaccta agcatttaaa     3000

atccattggt cttctgtcac ccgattttca agaagacaat gaaacagaaa taaacttcct     3060

gctcaaacaa gcactcacga ttgttgggac tctgccattt acttacatgt tagagaagtg     3120

gaggtggatg gtctttaaag gggaaattcc caaagaccag tggatgaaaa agtggtggga     3180

gatgaagcga gagatagttg gggtggtgga acctgtgccc catgatgaaa catactgtga     3240

ccccgcatct ctgttccatg tttctaatga ttactcattc attcgatatt acacaaggac     3300

cctttaccaa ttccagtttc aagaagcact ttgtcaagca gctaaacatg aaggccctct     3360

gcacaaatgt gacatctcaa actctacaga agctggacag aaactgttca atatgctgag     3420

gcttggaaaa tcagaaccct ggaccctagc attggaaaat gttgtaggag caaagaacat     3480

gaatgtaagg ccactgctca actactttga gcccttattt acctggctga aagaccagaa     3540

caagaattct tttgtgggat ggagtaccga ctggagtcca tatgcagacg agtctaagta     3600

cggccctcct tgtccttcct gccccgctcc tgaatttctc ggcggacctt ccgtgttcct     3660

gtttcctcca aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgcgt     3720

ggtggtggac gtgtcccaag aggatcctga ggtgcagttc aattggtacg tcgacggcgt     3780

ggaagtgcac aacgccaaga ccaagcctag agaggaacag ttcaacagca cctacagagt     3840

ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac ggcaaagagt acaagtgcaa     3900

ggtgtccaac aagggcctgc caagcagcat cgagaaaacc atcagcaagg ccaagggcca     3960

gcctagggaa ccccaggttt acacactgcc tccaagccaa gaggaaatga ccaagaacca     4020

ggtgtccctg acctgcctgg tcaagggctt ctacccttcc gatatcgccg tggaatggga     4080

gagcaacggc cagcctgaga acaactacaa gaccacacct cctgtgctgg acagcgacgg     4140

ctcattcttc ctgtactccc ggctgaccgt ggacaagtcc agatggcaag agggcaacgt     4200

gttcagctgc agcgtgatgc acgaggccct gcacaatcac tacacccaga agtccctgag     4260

tctgagcctg ggcaagtgat gaggtacctc tagagtcgac ccgggcggcc tcgaggacgg     4320

ggtgaactac gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat     4380

gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt     4440

gtgttggaat tttttgtgtc tctcactcg                                       4469


<210>  118
<211>  4469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette cb7-ci-hace2gen3-3-fc4-rbg


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE enhancer

<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  CB7 promoter

<220>
<221>  promoter
<222>  (385)..(666)
<223>  CB promoter

<220>
<221>  Intron
<222>  (759)..(1731)
<223>  chicken beta actin intron

<220>
<221>  misc_feature
<222>  (1745)..(1795)
<223>  ACE2 signal peptide

<220>
<221>  misc_feature
<222>  (1745)..(3589)
<223>  hAce2 (Varinat 3) (Gen3-3)

<220>
<221>  misc_feature
<222>  (1745)..(4276)
<223>  hAce2 (variant 3) (Gen3-3) IgG4

<220>
<221>  misc_feature
<222>  (3590)..(4276)
<223>  Human IgG4 Fc

<220>
<221>  polyA_signal
<222>  (4343)..(4469)
<223>  rabit beta globin polyA

<400>  118
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcccgc     1740

caccatgtca agctcttcct ggctccttct cagccttgtt gctgtaactg ctgctcagtc     1800

caccattgag gaacaggcca agacattttt ggacaggttt aaccacgtag ccgaagaccc     1860

gttctatcaa agttcacttg cttcttggaa ttataacacc aatatcactg aagagaatgc     1920

ccaaaacatg aataatgctg gggacaaatg gtctgccttt ttaaaggaac agtccacatt     1980

tgcccaaatg tatccactac aagaaattca ggacctcaca gtcaagcttc agctgcaggc     2040

tcttcagcaa aatgggtctt cagtgctctc agaagacaag agcaaacggt tgaacacaat     2100

tctaaataca atgagcacca tctacagtac tggaaaagtt tgtaacccgg ataatccaca     2160

agaatgctta ttacttgaac caggtttgaa tgaaataatg gcaaacagtt tagactacaa     2220

tgagaggctc tgggcttggg aaagctggag atctgaggtc ggcaagcagc tgaggccatt     2280

atatgaagag tatgtggtct tgaaaaatga gatggcgaga gcaaaccatt atgaggacta     2340

tggggattat tggagaggag actatgaagt aaatggggta gatggctatg actacagccg     2400

cggccagttg attgaagatg tggaacatac ctttgaagag attaaaccat tatatgaaca     2460

tcttcatgcc tatgtgaggg caaagttgat gaatgcctat ccttcctata tcagtccaat     2520

tggatgcctc cctgctcatt tgcttggtga tatgtggggt agattttgga caaatctgta     2580

ctctttgaca gttcccttcg gacagaaacc aaacatagat gttactgatg caatggtgga     2640

ccaggcctgg gatgcacaga gaatattcaa ggaggccgag aagttctttg tatctgttgg     2700

tcttcctaat atgactcaag gattctggga atattccatg ctaacggacc caggaaatgt     2760

tcagaaagca gtctgccatc ccacagcttg ggacctgggg aagggcgact tcaggatcct     2820

tatgtgcaca aaggtgacaa tggacgactt cctgacagct catcatgaga tggggcatat     2880

ccagtatgat atggcatatg ctgcacaacc ttttctgcta agaaatggag ctaatgaagg     2940

attccatgaa gctgttgggg aaatcatgtc actttctgca gccacaccta agcatttaaa     3000

atccattggt cttctgtcac ccgattttca agaagacaat gaaacagaaa taaacttcct     3060

gctcaaacaa gcactcacga ttgttgggac tctgccattt acttacatgt tagagaagtg     3120

gaggtggatg gtctttaaag gggaaattcc caaagaccag tggatgaaaa agtggtggga     3180

gatgaagcga gagatagttg gggtggtgga acctgtgccc catgatgaaa catactgtga     3240

ccccgcatct ctgttccatg tttctaatga ttactcattc attcgatatt acacaaggac     3300

cctttaccaa ttccagtttc aagaagcact ttgtcaagca gctaaacatg aaggccctct     3360

gcacaaatgt gacatctcaa actctacaga agctggacag aaactgttca atatgctgag     3420

gcttggaaaa tcagaaccct ggaccctagc attggaaaat gttgtaggag caaagaacat     3480

gaatgtaagg ccactgctca actactttga gcccttattt acctggctga aagaccagaa     3540

caagaattct tttgtgggat ggagtaccga ctggagtcca tatgcagacg agtctaagta     3600

cggccctcct tgtccttcct gccccgctcc tgaatttctc ggcggacctt ccgtgttcct     3660

gtttcctcca aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgcgt     3720

ggtggtggac gtgtcccaag aggatcctga ggtgcagttc aattggtacg tcgacggcgt     3780

ggaagtgcac aacgccaaga ccaagcctag agaggaacag ttcaacagca cctacagagt     3840

ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac ggcaaagagt acaagtgcaa     3900

ggtgtccaac aagggcctgc caagcagcat cgagaaaacc atcagcaagg ccaagggcca     3960

gcctagggaa ccccaggttt acacactgcc tccaagccaa gaggaaatga ccaagaacca     4020

ggtgtccctg acctgcctgg tcaagggctt ctacccttcc gatatcgccg tggaatggga     4080

gagcaacggc cagcctgaga acaactacaa gaccacacct cctgtgctgg acagcgacgg     4140

ctcattcttc ctgtactccc ggctgaccgt ggacaagtcc agatggcaag agggcaacgt     4200

gttcagctgc agcgtgatgc acgaggccct gcacaatcac tacacccaga agtccctgag     4260

tctgagcctg ggcaagtgat gaggtacctc tagagtcgac ccgggcggcc tcgaggacgg     4320

ggtgaactac gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat     4380

gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt     4440

gtgttggaat tttttgtgtc tctcactcg                                       4469


<210>  119
<211>  4469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette cb7-ci-hace2gen3-5-fc4-rbg


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE enhancer

<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (385)..(666)
<223>  CB promoter

<220>
<221>  Intron
<222>  (759)..(1731)
<223>  chicken beta actin intron

<220>
<221>  misc_feature
<222>  (1745)..(1795)
<223>  ACE2 signal peptide

<220>
<221>  misc_feature
<222>  (1745)..(3589)
<223>  hAce2 (variant 4) (GTP14-Gen3-5)

<220>
<221>  misc_feature
<222>  (1745)..(4276)
<223>  hAce2(varinat 4) (GTP14 Gen3-5) IgG4

<220>
<221>  misc_feature
<222>  (3590)..(4276)
<223>  Human IgG4Fc

<220>
<221>  polyA_signal
<222>  (4343)..(4469)
<223>  Rabbit beta globin polyA

<400>  119
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcccgc     1740

caccatgtca agctcttcct ggctccttct cagccttgtt gctgtaactg ctgctcagtc     1800

caccattgag gaacaggcca agacattttt ggacatgttt aaccacaaag ccgaagacct     1860

gttctatcaa agttcacttg cttcttggaa ttataacacc aatattactg aagagaatgt     1920

ccaaaacatg aataatgctg gggacaaatg gtctgccttt ttaaaggaac agtccacaat     1980

tgcccaaatg tatccactac aagaaattca gaatcccaca gtcaagcttc agctgcaggc     2040

tcttcagcaa aatgggtctt cagtgctctc agaagacaag agcaaacggt tgaacacaat     2100

tctaaataca atgagcacca tctacagtac tggaaaagtt tgtaacccgg ataatccaca     2160

agaatgctta ttacttgaac caggtttgaa tgaaataatg gcaaacagtt tagactacaa     2220

tgagaggctc tgggcttggg aaagctggag atctgaggtc ggcaagcagc tgaggccatt     2280

atatgaagag tatgtggtct tgaaaaatga gatggcgaga gcaaaccatt atgaggacta     2340

tggggattat tggagaggag actatgaagt aaatggggta gatggctatg actacagccg     2400

cggccagttg attgaagatg tggaacatac ctttgaagag attaaaccat tatatgaaca     2460

tcttcatgcc tatgtgaggg caaagttgat gaatgcctat ccttcctata tcagtccaat     2520

tggatgcctc cctgctcatt tgcttggtga tatgtggggt agattttgga caaatctgta     2580

ctctttgaca gttcccttcg gacagaaacc aaacatagat gttactgatg caatggtgga     2640

ccaggcctgg gatgcacaga gaatattcaa ggaggccgag aagttctttg tatctgttgg     2700

tcttcctaat atgactcaag gattctggga atattccatg ctaacggacc caggaaatgt     2760

tcagaaagca gtctgccatc ccacagcttg ggacctgggg aagggcgact tcaggatcct     2820

tatgtgcaca aaggtgacaa tggacgactt cctgacagct catcatgaga tggggcatat     2880

ccagtatgat atggcatatg ctgcacaacc ttttctgcta agaaatggag ctaatgaagg     2940

attccatgaa gctgttgggg aaatcatgtc actttctgca gccacaccta agcatttaaa     3000

atccattggt cttctgtcac ccgattttca agaagacaat gaaacagaaa taaacttcct     3060

gctcaaacaa gcactcacga ttgttgggac tctgccattt acttacatgt tagagaagtg     3120

gaggtggatg gtctttaaag gggaaattcc caaagaccag tggatgaaaa agtggtggga     3180

gatgaagcga gagatagttg gggtggtgga acctgtgccc catgatgaaa catactgtga     3240

ccccgcatct ctgttccatg tttctaatga ttactcattc attcgatatt acacaaggac     3300

cctttaccaa ttccagtttc aagaagcact ttgtcaagca gctaaacatg aaggccctct     3360

gcacaaatgt gacatctcaa actctacaga agctggacag aaactgttca atatgctgag     3420

gcttggaaaa tcagaaccct ggaccctagc attggaaaat gttgtaggag caaagaacat     3480

gaatgtaagg ccactgctca actactttga gcccttattt acctggctga aagaccagaa     3540

caagaattct tttgtgggat ggagtaccga ctggagtcca tatgcagacg agtctaagta     3600

cggccctcct tgtccttcct gccccgctcc tgaatttctc ggcggacctt ccgtgttcct     3660

gtttcctcca aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgcgt     3720

ggtggtggac gtgtcccaag aggatcctga ggtgcagttc aattggtacg tcgacggcgt     3780

ggaagtgcac aacgccaaga ccaagcctag agaggaacag ttcaacagca cctacagagt     3840

ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac ggcaaagagt acaagtgcaa     3900

ggtgtccaac aagggcctgc caagcagcat cgagaaaacc atcagcaagg ccaagggcca     3960

gcctagggaa ccccaggttt acacactgcc tccaagccaa gaggaaatga ccaagaacca     4020

ggtgtccctg acctgcctgg tcaagggctt ctacccttcc gatatcgccg tggaatggga     4080

gagcaacggc cagcctgaga acaactacaa gaccacacct cctgtgctgg acagcgacgg     4140

ctcattcttc ctgtactccc ggctgaccgt ggacaagtcc agatggcaag agggcaacgt     4200

gttcagctgc agcgtgatgc acgaggccct gcacaatcac tacacccaga agtccctgag     4260

tctgagcctg ggcaagtgat gaggtacctc tagagtcgac ccgggcggcc tcgaggacgg     4320

ggtgaactac gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat     4380

gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt     4440

gtgttggaat tttttgtgtc tctcactcg                                       4469


<210>  120
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV IE Enhancer

<400>  120
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt ac                                               382


<210>  121
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB promoter

<400>  121
tggtcgaggt gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc       60

caattttgta tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg      120

gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg aggcggagag      180

gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc      240

ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc gg                         282


<210>  122
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB7 hybrid promoter

<400>  122
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgg                                                                 666


<210>  123
<211>  973
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chicken beta actin intron (chimeric intron)

<400>  123
gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg       60

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc      120

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc      180

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc      240

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag      300

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg      360

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct      420

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg      480

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag      540

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc      600

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag      660

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc      720

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt      780

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc      840

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt      900

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat      960

cattttggca aag                                                         973


<210>  124
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rabbit beta globin polyA

<400>  124
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  125
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA1 Fc region

<400>  125

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  126
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA2 Fc region

<400>  126

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Ser Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Tyr Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Glu Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Ile Asn Val Ser Val Val Met Ala Glu Ala Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  127
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J chain

<400>  127

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


