                         SEQUENCE LISTING

<110>  Amgen Inc.
 
<120>  Materials and Methods for Treating Cancer by Administering an 
       Anti-MCL1 Antibody

<130>  32328/55149A

<150>  US 63/143,682
<151>  2021-01-29

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
caagctagcc agtctttata caacaacaac tatttaggc                              39


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
caagctagca agctggccag c                                                 21


<210>  3
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
gccggtttag acaacgacga catcttcagc                                        30


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gln Ala Ser Gln Ser Leu Tyr Asn Asn Asn Tyr Leu Gly 
1               5                   10              


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ala Gly Leu Asp Asn Asp Asp Ile Phe Ser 
1               5                   10  


<210>  7
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
cagagcagcc agaccgtgta caacaacaac gatttagct                              39


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
gatgccagcg atctgcccag c                                                 21


<210>  9
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ttaggaggct acgactgcgt gagcggcgac tgcattgcc                              39


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Gln Ser Ser Gln Thr Val Tyr Asn Asn Asn Asp Leu Ala 
1               5                   10              


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Asp Ala Ser Asp Leu Pro Ser 
1               5           


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Leu Gly Gly Tyr Asp Cys Val Ser Gly Asp Cys Ile Ala 
1               5                   10              


<210>  13
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
cgtttcggca ttagc                                                        15


<210>  14
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
atcatctctc gtaacgacat cacctactac gccaactggg ccaagggt                    48


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
ggcggccccg gctattccga tagcagcgtg                                        30


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Arg Phe Gly Ile Ser 
1               5   


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Ile Ile Ser Arg Asn Asp Ile Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Gly Gly Pro Gly Tyr Ser Asp Ser Ser Val 
1               5                   10  


<210>  19
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
acccacacca tcatc                                                        15


<210>  20
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
atcatctacg acgtgggcgg cacctattac gccagctggg ctcgtggt                    48


<210>  21
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
tacggcatc                                                                9


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Thr His Thr Ile Ile 
1               5   


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Ile Ile Tyr Asp Val Gly Gly Thr Tyr Tyr Ala Ser Trp Ala Arg Gly 
1               5                   10                  15      


<210>  24
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Tyr Gly Ile 
1           


<210>  25
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
gcccaagttc tgacccagac cccttccagc gtgagcgctg ccgtgggcgg aacagtgacc       60

atcaactgcc aagctagcca gtctttatac aacaacaact atttaggctg gtaccagcag      120

aaggccggac agagccccaa gctgctgatc taccaagcta gcaagctggc cagcggagtg      180

cctagccagt tcaagggcag cggcagcggc accgacttta ctttaaccat caccgatgtg      240

cagtgcgacg acgccggcac ctattactgc gccggtttag acaacgacga catcttcagc      300

tttggcggcg gcaccgaggt ggtggtgagg                                       330


<210>  26
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
cagagcgtga aggagagcgg cggcggttta ttcaagccta ccgacacttt aactttaact       60

tgtaccgtga gcggcatcga tttatctcgt ttcggcatta gctgggtgag acaagctccc      120

ggtaaaggtt tagagtggat cggcatcatc tctcgtaacg acatcaccta ctacgccaac      180

tgggccaagg gtcgtgtgac catcagcaag cccagcagca ccaccgtgga tttaaagctg      240

accagcccta ccaccgagga caccgccacc tacttctgcg tgagaggcgg ccccggctat      300

tccgatagca gcgtgtgggg acccggtact ttagtgaccg tgtcttta                   348


<210>  27
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Leu Tyr Asn Asn 
            20                  25                  30          


Asn Tyr Leu Gly Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Gln Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asp Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Gly Thr Tyr Tyr Cys Ala Gly Leu Asp Asn Asp 
                85                  90                  95      


Asp Ile Phe Ser Phe Gly Gly Gly Thr Glu Val Val Val Arg 
            100                 105                 110 


<210>  28
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Gln Ser Val Lys Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Phe Gly 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Arg Asn Asp Ile Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Val Thr Ile Ser Lys Pro Ser Ser Thr Thr Val Asp Leu Lys Leu 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Gly 
                85                  90                  95      


Gly Pro Gly Tyr Ser Asp Ser Ser Val Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Leu 
        115     


<210>  29
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gcccaagttc tgacccagac ccctagcagc gtgtccgctg ctgtgggcgg aaccgtgacc       60

atcaactgcc agagcagcca gaccgtgtac aacaacaacg atttagcttg gtaccagcag      120

aagcccggcc agcctcccaa gctgctgatc tacgatgcca gcgatctgcc cagcggcgtg      180

cctagcagat ttagcggcag cggcagcggc accgatttca ctttaaccat ctccgacgtg      240

cagtgcgatg acgccgccac ctactactgt ttaggaggct acgactgcgt gagcggcgac      300

tgcattgcct tcggaggcgg caccgaggtg gtggtgaag                             339


<210>  30
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
cagtctttag aggagagcgg aggcagactg gtgacccccg gtacacctct gactttaact       60

tgtaccgcca gcggctttac catcagcacc cacaccatca tctgggtgag acaagctccc      120

ggtaagggtt tagagtacat cggcatcatc tacgacgtgg gcggcaccta ttacgccagc      180

tgggctcgtg gtcgtttcac catcagcaag accagcacca ccgtggattt aaagatcacc      240

agccccacca ccgaggatac cgccacctac ttctgtaccg gctacggcat ctggggaccc      300

ggtactttag tgacagtgtc ttta                                             324


<210>  31
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Thr Val Tyr Asn Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Pro Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Cys 
                85                  90                  95      


Val Ser Gly Asp Cys Ile Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  32
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Thr His Thr 
            20                  25                  30          


Ile Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Tyr Asp Val Gly Gly Thr Tyr Tyr Ala Ser Trp Ala Arg Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Gly Tyr Gly 
                85                  90                  95      


Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu 
            100                 105             


<210>  33
<211>  350
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  MISC_FEATURE
<222>  (29)..(47)
<223>  Peptide Design 1

<220>
<221>  MISC_FEATURE
<222>  (123)..(139)
<223>  Peptide Design 4

<220>
<221>  MISC_FEATURE
<222>  (148)..(166)
<223>  Peptide Design 6

<220>
<221>  MISC_FEATURE
<222>  (169)..(188)
<223>  Peptide Design 2

<220>
<221>  MISC_FEATURE
<222>  (169)..(188)
<223>  Peptide Design 2

<220>
<221>  MISC_FEATURE
<222>  (209)..(224)
<223>  BH3

<220>
<221>  MISC_FEATURE
<222>  (227)..(246)
<223>  Peptide Design 5

<220>
<221>  MISC_FEATURE
<222>  (252)..(271)
<223>  BH1

<220>
<221>  MISC_FEATURE
<222>  (252)..(271)
<223>  BH1

<220>
<221>  MISC_FEATURE
<222>  (271)..(271)
<223>  End of Isoform 1

<220>
<221>  MISC_FEATURE
<222>  (302)..(319)
<223>  Peptide Design 3

<220>
<221>  MISC_FEATURE
<222>  (303)..(316)
<223>  BH2

<220>
<221>  MISC_FEATURE
<222>  (328)..(348)
<223>  Transmembrane

<400>  33

Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      


Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          


Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              


Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  


Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  


Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      


Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         


Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             


Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 


Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 


Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Asp Leu Tyr Arg 
                165                 170                 175     


Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         


Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             


Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 


Glu Thr Ala Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu 
225                 230                 235                 240 


Asp Asp Val Lys Ser Leu Ser Arg Val Met Ile His Val Phe Ser Asp 
                245                 250                 255     


Gly Val Thr Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala 
            260                 265                 270         


Phe Val Ala Lys His Leu Lys Thr Ile Asn Gln Glu Ser Cys Ile Glu 
        275                 280                 285             


Pro Leu Ala Glu Ser Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp 
    290                 295                 300                 


Trp Leu Val Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His 
305                 310                 315                 320 


Val Glu Asp Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala 
                325                 330                 335     


Gly Val Ala Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
            340                 345                 350 


<210>  34
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  34
ccaggtgacg gt                                                           12


<210>  35
<211>  24
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  35
aggaacccag catggacact cgaa                                              24


<210>  36
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  36
ggatcaggat atttattctg ccacgacaca                                        30


<210>  37
<211>  12
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  37
tgcccgagtt cc                                                           12


<210>  38
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  38
agacgactca ccatggagac t                                                 21


<210>  39
<211>  17
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  39
actggctccg ggaggta                                                      17


