                         SEQUENCE LISTING

<110>  DICERNA PHARMACEUTICALS, INC.
 
<120>  COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION IN THE 
       CENTRAL NERVOUS SYSTEM

<130>  DICN-006/001WO 344302-2071

<140>  PCT/US2022/014346
<141>  2022-01-28

<150>  US 63/142,877
<151>  2021-01-28

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  1
uaaacugagu uucauccacc gg                                                22


<210>  2
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  2
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  3
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(3)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'- fluoro modified

<220>  
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  3
uaaacugagu uucauccacc gg                                                22


<210>  4
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  4
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  5
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C8:0)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  5
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  6
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C10:0)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  6
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  7
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C12:0)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  7
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  8
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C14:0)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  8
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  9
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C16:0)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  9
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  10
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C18:0)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  10
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  11
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C18:1)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  11
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  12
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate


<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C18:2)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  12
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  13
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C22:0)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  13
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  14
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>  
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'- fluoro modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  Lipid (C22:6)-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  14
gguggaugaa acucaguuua gcagccgaaa ggcugc                                 36


<210>  15
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  15
gcagccgaaa ggcugc                                                       16


