                               SEQUENCE LISTING

<110> ASTRIA THERAPEUTICS, INC.
 
<120> PLASMA KALLIKREIN ANTIBODIES AND USES THEREOF

<130> AST-001WO

<140>
<141>

<150> 63/262,838
<151> 2021-10-21

<150> 63/220,194
<151> 2021-07-09

<150> 63/159,323
<151> 2021-03-10

<150> 63/142,748
<151> 2021-01-28

<160> 49    

<170> PatentIn version 3.5

<210> 1
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Gly Ser Leu Met Val Thr Thr Gly Ala Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210> 2
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ser Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 3
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Gly Ser Leu Met Val Thr Thr Gly Ala Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 4
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 5
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn Tyr Asn Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Gly Ser Leu Met Val Thr Thr Gly Ala Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 6
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser His Arg Gly Trp Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 7
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn Tyr Asn Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Gly Ser Leu Met Val Thr Thr Gly Ala Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210> 8
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser His Arg Gly Trp Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 9
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn Tyr Asn Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Gly Ser Leu Met Val Thr Thr Gly Ala Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
            420                 425                 430         


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210> 10
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn Tyr Asn Ala Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Gly Ser Leu Met Val Thr Thr Gly Ala Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
                245                 250                 255     


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Lys Ala Ser Gln Asp Val Gly Ile Ala Val Ala 
1               5                   10      


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Trp Ala Ser Thr Arg His Thr 
1               5           


<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gln Gln Tyr Arg Ser Tyr Pro Leu Thr 
1               5                   


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ser Tyr Trp Met Asn 
1               5   


<210> 15
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 16
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Ser Leu Met Val Thr Thr Gly Ala Pro Phe Asp Tyr 
1               5                   10          


<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn Tyr Asn Gly Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Tyr Ala Ser His Arg Gly Trp 
1               5           


<210> 19
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn Tyr Asn Ala Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ser Gln Asp Val Gly Ile Ala 
1               5           


<210> 21
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Trp Ala Ser 
1           


<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Tyr Arg Ser Tyr Pro Leu Thr 
1               5           


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gly Tyr Ala Phe Ser Ser Tyr 
1               5           


<210> 24
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Tyr Pro Gly Asp Asp Asp 
1               5       


<210> 25
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Ser Leu Met Val Thr Thr Gly Ala Pro Phe Asp Tyr 
1               5                   10          


<210> 26
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Tyr Ala Ser 
1           


<210> 27
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gln Asp Val Gly Ile Ala 
1               5       


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gln Gln Tyr Arg Ser Tyr Pro Leu Thr 
1               5                   


<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Tyr Ala Phe Ser Ser Tyr Trp 
1               5               


<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ile Tyr Pro Gly Asp Asp Asp Thr 
1               5               


<210> 31
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Ala Gly Ser Leu Met Val Thr Thr Gly Ala Pro Phe Asp Tyr 
1               5                   10                  


<210> 32
<211> 638
<212> PRT
<213> Homo sapiens

<400> 32
Met Ile Leu Phe Lys Gln Ala Thr Tyr Phe Ile Ser Leu Phe Ala Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln 
        35                  40                  45              


Met Arg Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 
    50                  55                  60                  


Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 
65                  70                  75                  80  


Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala Val 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His 
            100                 105                 110         


Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly Val Asn Phe Asn Val 
        115                 120                 125             


Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Asn Asn 
    130                 135                 140                 


Ile Arg Cys Gln Phe Phe Ser Tyr Ala Thr Gln Thr Phe His Lys Ala 
145                 150                 155                 160 


Glu Tyr Arg Asn Asn Cys Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro 
                165                 170                 175     


Thr Ala Ile Lys Val Leu Ser Asn Val Glu Ser Gly Phe Ser Leu Lys 
            180                 185                 190         


Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His 
        195                 200                 205             


Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp Ala 
    210                 215                 220                 


Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Asn Cys Leu Phe Phe 
225                 230                 235                 240 


Thr Phe Tyr Thr Asn Val Trp Lys Ile Glu Ser Gln Arg Asn Val Cys 
                245                 250                 255     


Leu Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln 
            260                 265                 270         


Glu Asn Thr Ile Ser Gly Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu 
        275                 280                 285             


Pro Glu Pro Cys His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly 
    290                 295                 300                 


Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu 
305                 310                 315                 320 


Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
                325                 330                 335     


Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser 
            340                 345                 350         


Met Asp Gly Ser Pro Thr Arg Ile Ala Tyr Gly Thr Gln Gly Ser Ser 
        355                 360                 365             


Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly Asp Asn Ser Val Cys Thr 
    370                 375                 380                 


Thr Lys Thr Ser Thr Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly 
385                 390                 395                 400 


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Thr Ala Gln Arg 
                405                 410                 415     


His Leu Cys Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala 
            420                 425                 430         


Ala His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr 
        435                 440                 445             


Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser 
    450                 455                 460                 


Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Lys Val Ser Glu Gly 
465                 470                 475                 480 


Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr 
                485                 490                 495     


Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Gly Asp Thr Ser Thr 
            500                 505                 510         


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Ser Lys Glu Lys 
        515                 520                 525             


Gly Glu Ile Gln Asn Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr 
    530                 535                 540                 


Asn Glu Glu Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg 
545                 550                 555                 560 


Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 
                565                 570                 575     


Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Gly Met Trp Arg Leu 
            580                 585                 590         


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro 
        595                 600                 605             


Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp Trp Ile Leu Glu Lys 
    610                 615                 620                 


Thr Gln Ser Ser Asp Gly Lys Ala Gln Met Gln Ser Pro Ala 
625                 630                 635             


<210> 33
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
caggttcagc tgcagcagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggagagg gtcttgagtg gattggacag atttatcctg gagatgatga tactaactac      180

aacggaaagt tcaagggcaa ggccacactg actgtagaca aatcctccac cacagcctac      240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aggatctttg      300

atggttacga cgggggcccc ctttgactac tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210> 34
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt attgctgttg cctggtatca acagaaacca      120

gggcaatctc ctaaatttct gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattaggaa tgtgcagtct      240

gaagacttgt cagattattt ctgtcagcaa tataggagct atcctctcac gttcggctcg      300

gggacaaagt tggaactaaa a                                                321


<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Gly Gly Gly Gly Ser 
1               5   


<210> 36
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gly Gly Gly Gly Ala 
1               5   


<210> 37
<211> 2
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MAb4-YTE epitope 1 sequence

<400> 37
Lys Arg 
1       


<210> 38
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MAb4-YTE epitope 2 sequence

<400> 38
Lys His Asn Gly Met Trp Arg Leu Val Gly Ile Thr Ser 
1               5                   10              


<210> 39
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MAb4-YTE epitope 3 sequence

<400> 39
Tyr Met Asp Trp Ile Leu Glu Lys Thr 
1               5                   


<210> 40
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      DX2930 epitope 1 sequence

<400> 40
His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg 
1               5                   10              


<210> 41
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      DX2930 epitope 2 sequence

<400> 41
Tyr Lys Val Ser Glu Gly Asn His 
1               5               


<210> 42
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      DX2930 epitope 3 sequence

<400> 42
Tyr Lys Ile Thr Gln Arg 
1               5       


<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Tyr Ala Phe Ser Ser Tyr Trp Met Asn 
1               5                   10  


<210> 44
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gln Ile Tyr Pro Gly Asp Asp Asp Thr Asn 
1               5                   10  


<210> 45
<211> 638
<212> PRT
<213> Macaca fascicularis

<400> 45
Met Ile Leu Phe Lys Gln Ala Thr Tyr Phe Ile Ser Leu Phe Ala Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Thr Ala Gln His Cys Gln 
        35                  40                  45              


Met Met Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 
    50                  55                  60                  


Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 
65                  70                  75                  80  


Asp Ser Val Thr Gly Thr Leu Pro Lys Val Arg Arg Ala Gly Ala Ile 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His 
            100                 105                 110         


Arg Asp Ile Tyr Lys Gly Ile Asp Met Arg Gly Val Asn Phe Asn Val 
        115                 120                 125             


Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Asn Asn 
    130                 135                 140                 


Ile Arg Cys Gln Phe Phe Ser Tyr Ala Thr Gln Thr Phe His Asn Ala 
145                 150                 155                 160 


Glu Tyr Arg Asn Thr Cys Leu Leu Lys His Ser Pro Gly Gly Thr Pro 
                165                 170                 175     


Thr Thr Ile Lys Val Leu Asn Asn Val Glu Ser Gly Phe Ser Leu Lys 
            180                 185                 190         


Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His 
        195                 200                 205             


Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Ala Pro Asp Ala 
    210                 215                 220                 


Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Ser Cys Leu Phe Phe 
225                 230                 235                 240 


Thr Phe Tyr Thr Asn Ala Trp Lys Ile Glu Ser Gln Arg Asn Val Cys 
                245                 250                 255     


Phe Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln 
            260                 265                 270         


Glu Asn Thr Thr Ser Gly Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu 
        275                 280                 285             


Pro Glu Pro Cys His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly 
    290                 295                 300                 


Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu 
305                 310                 315                 320 


Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
                325                 330                 335     


Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser 
            340                 345                 350         


Ser Asp Gly Ser Pro Thr Arg Ile Thr Tyr Gly Thr Gln Gly Ser Ser 
        355                 360                 365             


Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly Asp Ser Ser Val Cys Thr 
    370                 375                 380                 


Thr Lys Thr Ser Ser Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly 
385                 390                 395                 400 


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Met Ala Gln Arg 
                405                 410                 415     


His Leu Cys Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala 
            420                 425                 430         


Ala His Cys Phe Asp Gly Leu Pro Leu Pro Asp Val Trp Arg Ile Tyr 
        435                 440                 445             


Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Glu Thr Pro Phe Ser 
    450                 455                 460                 


Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Arg Ile Ser Glu Gly 
465                 470                 475                 480 


Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr 
                485                 490                 495     


Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Gly Asp Thr Asn Thr 
            500                 505                 510         


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Ser Lys Glu Lys 
        515                 520                 525             


Gly Glu Ile Gln Asp Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr 
    530                 535                 540                 


Asn Glu Glu Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg 
545                 550                 555                 560 


Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 
                565                 570                 575     


Asp Ser Gly Gly Pro Leu Ala Cys Lys His Asn Gly Met Trp Arg Leu 
            580                 585                 590         


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro 
        595                 600                 605             


Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp Trp Ile Leu Glu Lys 
    610                 615                 620                 


Thr Gln Ser Ser Asp Gly Asn Ala Arg Met Gln Ala Pro Ala 
625                 630                 635             


<210> 46
<211> 629
<212> PRT
<213> Oryctolagus cuniculus

<400> 46
Met Ile Pro Phe Arg Gln Ala Ala Tyr Phe Val Cys Leu Phe Thr Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Lys Asn Ala Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Val Thr Ser Met Tyr Ser Pro Asn Ala Gln His Cys Gln 
        35                  40                  45              


Met Met Cys Thr Phe His Pro Arg Cys Leu Phe Phe Ser Phe Leu Pro 
    50                  55                  60                  


Ala Ser Ser Thr Asn Asp Ala Gln Lys Arg Phe Gly Cys Phe Leu Lys 
65                  70                  75                  80  


Asp Ser Val Thr Gly Thr Leu Pro Arg Val His Gln Thr Asn Ala Ile 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Asn Ala Cys His 
            100                 105                 110         


Arg Ala Thr Tyr Glu Gly Ile Asp Met Arg Gly Thr Asn Phe Asn Ile 
        115                 120                 125             


Ser Lys Val Gln Ser Val Glu Glu Cys Gln Lys Gln Cys Thr Asp Asn 
    130                 135                 140                 


Ile His Cys Gln Phe Phe Thr Tyr Ala Thr Gln Thr Phe Tyr Asn Ala 
145                 150                 155                 160 


Glu His Leu Asn Asn Cys Ile Leu Lys Lys Ser Ala Thr Gly Thr Pro 
                165                 170                 175     


Ser Ser Ile Lys Leu Leu Glu Asn Val Val Ser Gly Phe Ser Leu Lys 
            180                 185                 190         


Pro Cys Ala Leu Ser Glu Ser Gly Cys His Met Asn Leu Phe Gln His 
        195                 200                 205             


Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp Ala 
    210                 215                 220                 


Phe Val Cys Arg Thr Ile Cys Thr Tyr His Ser Asn Cys Leu Phe Phe 
225                 230                 235                 240 


Thr Phe Tyr Thr Asn Glu Trp Asp Thr Glu Ser Gln Arg Asn Ala Cys 
                245                 250                 255     


Phe Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Phe Pro Thr Pro Gln 
            260                 265                 270         


Glu Asn Thr Ile Ser Gly Tyr Ser Leu Leu Thr Cys Lys Lys Thr Leu 
        275                 280                 285             


Pro Glu Pro Cys His Phe Lys Ile Tyr Ser Gly Val Asp Phe Gly Gly 
    290                 295                 300                 


Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Thr Leu Cys Gln Glu 
305                 310                 315                 320 


Thr Cys Thr Lys Thr Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
                325                 330                 335     


Pro Glu Asp Cys Lys Gly Glu Lys Cys Arg Cys Ser Leu Arg Leu Ser 
            340                 345                 350         


Leu Asp Gly Ser Pro Thr Ser Ile Thr His Gly Thr Gln Lys Ser Ser 
        355                 360                 365             


Gly Tyr Ser Leu Arg Leu Cys Lys Thr Glu Asn Gly Ser Val Cys Thr 
    370                 375                 380                 


Thr Lys Ile Asn Ala Arg Ile Val Gly Gly Ser Asn Ser Ser Arg Gly 
385                 390                 395                 400 


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Ala Ala Gln Ser 
                405                 410                 415     


His Val Cys Gly Gly Ser Ile Ile Gly His Gln Trp Val Leu Thr Ala 
            420                 425                 430         


Ala His Cys Phe Asp Gly Leu Pro Phe Pro Glu Ile Trp Arg Ile Tyr 
        435                 440                 445             


Gly Gly Ile Leu Tyr Leu Ser Glu Val Thr Lys Glu Thr Ala Phe Ser 
    450                 455                 460                 


Gln Ile Lys Glu Ile Ile Ile His Pro Lys Tyr Lys Ile Ser Glu Thr 
465                 470                 475                 480 


Gly His Asp Ile Ala Leu Ile Gln Leu Gln Ala Pro Leu Asn Asp Thr 
                485                 490                 495     


Asp Ile Gln Lys Pro Ile Cys Leu Pro Ser Lys Asp Asp Thr Asn Ala 
            500                 505                 510         


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Thr Lys Glu Lys 
        515                 520                 525             


Gly Glu Ile Gln Asn Ile Leu Gln Lys Ala Asn Ile Pro Leu Val Thr 
    530                 535                 540                 


Asn Glu Glu Cys Gln Lys Ser Tyr Arg Asp His Ala Ile Thr Lys Gln 
545                 550                 555                 560 


Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 
                565                 570                 575     


Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Asn Ile Trp Leu Leu 
            580                 585                 590         


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro 
        595                 600                 605             


Gly Val Tyr Thr Lys Val Ala Glu Tyr Val Asp Trp Ile Leu Gln Lys 
    610                 615                 620                 


Met Gln Glu Lys Asp 
625                 


<210> 47
<211> 638
<212> PRT
<213> Rattus norvegicus

<400> 47
Met Ile Leu Phe Lys Gln Val Gly Tyr Phe Val Ser Leu Phe Ala Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Ser Gln Leu Tyr Ala Asn Thr Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Leu Ala Ala Ile Tyr Thr Pro Asp Ala Gln His Cys Gln 
        35                  40                  45              


Lys Met Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Ala 
    50                  55                  60                  


Val Ser Pro Thr Lys Glu Thr Asp Lys Arg Phe Gly Cys Phe Met Lys 
65                  70                  75                  80  


Glu Ser Ile Thr Gly Thr Leu Pro Arg Ile His Arg Thr Gly Ala Ile 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Leu Ser Ala Cys His 
            100                 105                 110         


Gln Asp Ile Tyr Glu Gly Leu Asp Met Arg Gly Ser Asn Phe Asn Ile 
        115                 120                 125             


Ser Lys Thr Asp Ser Ile Glu Glu Cys Gln Lys Leu Cys Thr Asn Asn 
    130                 135                 140                 


Ile His Cys Gln Phe Phe Thr Tyr Ala Thr Lys Ala Phe His Arg Pro 
145                 150                 155                 160 


Glu Tyr Arg Lys Ser Cys Leu Leu Lys Arg Ser Ser Ser Gly Thr Pro 
                165                 170                 175     


Thr Ser Ile Lys Pro Val Asp Asn Leu Val Ser Gly Phe Ser Leu Lys 
            180                 185                 190         


Ser Cys Ala Leu Ser Glu Ile Gly Cys Pro Met Asp Ile Phe Gln His 
        195                 200                 205             


Phe Ala Phe Ala Asp Leu Asn Val Ser Gln Val Val Thr Pro Asp Ala 
    210                 215                 220                 


Phe Val Cys Arg Thr Val Cys Thr Phe His Pro Asn Cys Leu Phe Phe 
225                 230                 235                 240 


Thr Phe Tyr Thr Asn Glu Trp Glu Thr Glu Ser Gln Arg Asn Val Cys 
                245                 250                 255     


Phe Leu Lys Thr Ser Lys Ser Gly Arg Pro Ser Pro Pro Ile Ile Gln 
            260                 265                 270         


Glu Asn Ala Val Ser Gly Tyr Ser Leu Phe Thr Cys Arg Lys Ala Arg 
        275                 280                 285             


Pro Glu Pro Cys His Phe Lys Ile Tyr Ser Gly Val Ala Phe Glu Gly 
    290                 295                 300                 


Glu Glu Leu Asn Ala Thr Phe Val Gln Gly Ala Asp Ala Cys Gln Glu 
305                 310                 315                 320 


Thr Cys Thr Lys Thr Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
                325                 330                 335     


Pro Gln Asp Cys Lys Ala Glu Gly Cys Lys Cys Ser Leu Arg Leu Ser 
            340                 345                 350         


Thr Asp Gly Ser Pro Thr Arg Ile Thr Tyr Glu Ala Gln Gly Ser Ser 
        355                 360                 365             


Gly Tyr Ser Leu Arg Leu Cys Lys Val Val Glu Ser Ser Asp Cys Thr 
    370                 375                 380                 


Thr Lys Ile Asn Ala Arg Ile Val Gly Gly Thr Asn Ser Ser Leu Gly 
385                 390                 395                 400 


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Val Ser Gln Asn 
                405                 410                 415     


His Met Cys Gly Gly Ser Ile Ile Gly Arg Gln Trp Ile Leu Thr Ala 
            420                 425                 430         


Ala His Cys Phe Asp Gly Ile Pro Tyr Pro Asp Val Trp Arg Ile Tyr 
        435                 440                 445             


Gly Gly Ile Leu Asn Leu Ser Glu Ile Thr Asn Lys Thr Pro Phe Ser 
    450                 455                 460                 


Ser Ile Lys Glu Leu Ile Ile His Gln Lys Tyr Lys Met Ser Glu Gly 
465                 470                 475                 480 


Ser Tyr Asp Ile Ala Leu Ile Lys Leu Gln Thr Pro Leu Asn Tyr Thr 
                485                 490                 495     


Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Ala Asp Thr Asn Thr 
            500                 505                 510         


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Tyr Thr Lys Glu Arg 
        515                 520                 525             


Gly Glu Thr Gln Asn Ile Leu Gln Lys Ala Thr Ile Pro Leu Val Pro 
    530                 535                 540                 


Asn Glu Glu Cys Gln Lys Lys Tyr Arg Asp Tyr Val Ile Thr Lys Gln 
545                 550                 555                 560 


Met Ile Cys Ala Gly Tyr Lys Glu Gly Gly Ile Asp Ala Cys Lys Gly 
                565                 570                 575     


Asp Ser Gly Gly Pro Leu Val Cys Lys His Ser Gly Arg Trp Gln Leu 
            580                 585                 590         


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Lys Glu Gln Pro 
        595                 600                 605             


Gly Val Tyr Thr Lys Val Ala Glu Tyr Ile Asp Trp Ile Leu Glu Lys 
    610                 615                 620                 


Ile Gln Ser Ser Lys Glu Arg Ala Leu Glu Thr Ser Pro Ala 
625                 630                 635             


<210> 48
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 48
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta tgcattcagt agctactgga tgaactgggt gaggcaggct      120

cctggacagg gtcttgagtg gattggacag atttatcctg gagatgacga tactaactac      180

aatgccaagt tccaggggag ggtcaccatc accgtggaca aatccacaac taccgcctac      240

atggaactca gcagcctacg ctctgaggac acagccgtct atttctgtgc tggctccctg      300

atggttacta ccggcgcccc ttttgactac tggggccagg gaaccacggt caccgtctcc      360

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcttctaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctctacat cacccgggaa      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgagaga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tattccaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctcccggg                                      1350


<210> 49
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 49
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aagcaagtca ggacgtggga atcgctgtcg cctggtatca gcagaaacca      120

gggaaagccc ctaagttcct gatctattac gcatcccacc gcggatgggg cgtgcctgac      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttattt ctgtcaacag taccggtctt atcccctgac ctttggccaa      300

gggaccaagc tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agcttaagtc cggaactgct agcgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg aaactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


