                         SEQUENCE LISTING

<110>  CATALYST BIOSCIENCES, INC.
 
<120>  ENGINEERED CPN1 CONSTRUCTS AND VARIANTS

<130>  CTBI-005/02WO 338308-2121

<150>  US 63/222,929
<151>  2021-07-16

<150>  US 63/142,462
<151>  2021-01-27

<160>  490   

<170>  PatentIn version 3.5

<210>  1
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Asp Leu Leu Ser Val Phe Leu His Leu Leu Leu Leu Phe Lys 
1               5                   10                  15      


Leu Val Ala Pro Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val 
            20                  25                  30          


Arg Thr Leu Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val 
        35                  40                  45              


Tyr Ser Ile Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu 
    50                  55                  60                  


Phe Ser Asp His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys 
65                  70                  75                  80  


Tyr Val Gly Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met 
                85                  90                  95      


Leu Gln Leu Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln 
            100                 105                 110         


Arg Ile Val Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser 
        115                 120                 125             


Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys 
    130                 135                 140                 


Pro Gly Tyr Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn 
145                 150                 155                 160 


Arg Asn Phe Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr 
                165                 170                 175     


Gly Gly Pro Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln 
            180                 185                 190         


Val Glu Pro Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn 
        195                 200                 205             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr 
    210                 215                 220                 


Pro Tyr Asp Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr 
225                 230                 235                 240 


Ala Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys 
                245                 250                 255     


Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly 
            260                 265                 270         


Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu 
        275                 280                 285             


Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu 
    290                 295                 300                 


Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu 
305                 310                 315                 320 


Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu 
                325                 330                 335     


Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn 
            340                 345                 350         


Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val 
        355                 360                 365             


Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile 
    370                 375                 380                 


Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr 
385                 390                 395                 400 


Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys 
                405                 410                 415     


Arg Ser Ile Pro Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg 
            420                 425                 430         


His Gly Val Arg Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met 
        435                 440                 445             


Glu Met Arg Gln Leu Gln Arg Gly Pro Ala 
    450                 455             


<210>  2
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Leu Cys Ser Leu Ala Val Leu Val Pro Ile Val Leu Phe Cys 
1               5                   10                  15      


Glu Gln His Val Phe Ala Phe Gln Ser Gly Gln Val Leu Ala Ala Leu 
            20                  25                  30          


Pro Arg Thr Ser Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr 
        35                  40                  45              


Tyr Glu Ile Val Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys 
    50                  55                  60                  


Lys Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val 
65                  70                  75                  80  


Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala 
                85                  90                  95      


Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser 
            100                 105                 110         


Pro Arg Ala Ser Ala Ser Tyr Tyr Glu Gln Tyr His Ser Leu Asn Glu 
        115                 120                 125             


Ile Tyr Ser Trp Ile Glu Phe Ile Thr Glu Arg His Pro Asp Met Leu 
    130                 135                 140                 


Thr Lys Ile His Ile Gly Ser Ser Phe Glu Lys Tyr Pro Leu Tyr Val 
145                 150                 155                 160 


Leu Lys Val Ser Gly Lys Glu Gln Ala Ala Lys Asn Ala Ile Trp Ile 
                165                 170                 175     


Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Leu 
            180                 185                 190         


Trp Phe Ile Gly His Ile Thr Gln Phe Tyr Gly Ile Ile Gly Gln Tyr 
        195                 200                 205             


Thr Asn Leu Leu Arg Leu Val Asp Phe Tyr Val Met Pro Val Val Asn 
    210                 215                 220                 


Val Asp Gly Tyr Asp Tyr Ser Trp Lys Lys Asn Arg Met Trp Arg Lys 
225                 230                 235                 240 


Asn Arg Ser Phe Tyr Ala Asn Asn His Cys Ile Gly Thr Asp Leu Asn 
                245                 250                 255     


Arg Asn Phe Ala Ser Lys His Trp Cys Glu Glu Gly Ala Ser Ser Ser 
            260                 265                 270         


Ser Cys Ser Glu Thr Tyr Cys Gly Leu Tyr Pro Glu Ser Glu Pro Glu 
        275                 280                 285             


Val Lys Ala Val Ala Ser Phe Leu Arg Arg Asn Ile Asn Gln Ile Lys 
    290                 295                 300                 


Ala Tyr Ile Ser Met His Ser Tyr Ser Gln His Ile Val Phe Pro Tyr 
305                 310                 315                 320 


Ser Tyr Thr Arg Ser Lys Ser Lys Asp His Glu Glu Leu Ser Leu Val 
                325                 330                 335     


Ala Ser Glu Ala Val Arg Ala Ile Glu Lys Ile Ser Lys Asn Thr Arg 
            340                 345                 350         


Tyr Thr His Gly His Gly Ser Glu Thr Leu Tyr Leu Ala Pro Gly Gly 
        355                 360                 365             


Gly Asp Asp Trp Ile Tyr Asp Leu Gly Ile Lys Tyr Ser Phe Thr Ile 
    370                 375                 380                 


Glu Leu Arg Asp Thr Gly Thr Tyr Gly Phe Leu Leu Pro Glu Arg Tyr 
385                 390                 395                 400 


Ile Lys Pro Thr Cys Arg Glu Ala Phe Ala Ala Val Ser Lys Ile Ala 
                405                 410                 415     


Trp His Val Ile Arg Asn Val 
            420             


<210>  3
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Met Lys Leu Cys Ser Leu Ala Val Leu Val Pro Ile Val Leu Phe Cys 
1               5                   10                  15      


Glu Gln His Val Phe Ala Phe Gln Ser Gly Gln Val Leu Ala Ala Leu 
            20                  25                  30          


Pro Arg Thr Ser Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr 
        35                  40                  45              


Tyr Glu Ile Val Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys 
    50                  55                  60                  


Lys Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val 
65                  70                  75                  80  


Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala 
                85                  90                  95      


Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser 
            100                 105                 110         


Pro Arg Ala Ser Ala Ser Tyr Tyr Val Thr Phe Arg His His Arg Tyr 
        115                 120                 125             


Asp Asp Leu Val Arg Thr Leu Tyr Lys Val Gln Asn Glu Cys Pro Gly 
    130                 135                 140                 


Ile Thr Arg Val Tyr Ser Ile Gly Arg Ser Val Glu Gly Arg His Leu 
145                 150                 155                 160 


Tyr Val Leu Glu Phe Ser Asp His Pro Gly Ile His Glu Pro Leu Glu 
                165                 170                 175     


Pro Glu Val Lys Tyr Val Gly Asn Met His Gly Asn Glu Ala Leu Gly 
            180                 185                 190         


Arg Glu Leu Met Leu Gln Leu Ser Glu Phe Leu Cys Glu Glu Phe Arg 
        195                 200                 205             


Asn Arg Asn Gln Arg Ile Val Gln Leu Ile Gln Asp Thr Arg Ile His 
    210                 215                 220                 


Ile Leu Pro Ser Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Gln 
225                 230                 235                 240 


Gly Pro Asn Lys Pro Gly Tyr Leu Val Gly Arg Asn Asn Ala Asn Gly 
                245                 250                 255     


Val Asp Leu Asn Arg Asn Phe Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr 
            260                 265                 270         


Asn Glu Lys Tyr Gly Gly Pro Asn His His Leu Pro Leu Pro Asp Asn 
        275                 280                 285             


Trp Lys Ser Gln Val Glu Pro Glu Thr Arg Ala Val Ile Arg Trp Met 
    290                 295                 300                 


His Ser Phe Asn Phe Val Leu Ser Ala Asn Leu His Gly Gly Ala Val 
305                 310                 315                 320 


Val Ala Asn Tyr Pro Tyr Asp Lys Ser Phe Glu His Arg Val Arg Gly 
                325                 330                 335     


Val Arg Arg Thr Ala Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln 
            340                 345                 350         


Lys Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly 
        355                 360                 365             


Trp Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser 
    370                 375                 380                 


Trp Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr 
385                 390                 395                 400 


Asn Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro 
                405                 410                 415     


Glu Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile 
            420                 425                 430         


Gln Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp 
        435                 440                 445             


Glu Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser 
    450                 455                 460 


<210>  4
<211>  77
<212>  PRT
<213>  Unknown

<220>
<223>  C3a peptide substrate

<400>  4

Ser Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro 
1               5                   10                  15      


Lys Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met 
            20                  25                  30          


Arg Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala 
        35                  40                  45              


Cys Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg 
    50                  55                  60                  


Arg Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg 
65                  70                  75          


<210>  5
<211>  74
<212>  PRT
<213>  Unknown

<220>
<223>  C5a peptide substrate

<400>  5

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser His Lys Asp Met Gln Leu Gly Arg 
65                  70                  


<210>  6
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
385                 390                 395                 400 


Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly Val Arg 
                405                 410                 415     


Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln 
            420                 425                 430         


Leu Gln Arg Gly Pro Ala 
        435             


<210>  7
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  8
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


<210>  9
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPN1-HSA

<400>  9

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  10
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe 
            20                  25                  30          


Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr 
        35                  40                  45              


Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr 
    50                  55                  60                  


Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asn 
65                  70                  75                  80  


Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg 
                85                  90                  95      


Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr 
            100                 105                 110         


Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe 
        115                 120                 125             


Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala 
    130                 135                 140                 


Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg 
145                 150                 155                 160 


Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln 
                165                 170                 175     


Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser 
            180                 185                 190         


Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln 
        195                 200                 205             


Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser 
    210                 215                 220                 


Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys 
225                 230                 235                 240 


Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu 
                245                 250                 255     


Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp 
            260                 265                 270         


Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys 
        275                 280                 285             


Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala Glu 
    290                 295                 300                 


Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr 
305                 310                 315                 320 


Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu 
                325                 330                 335     


Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro 
            340                 345                 350         


Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys 
        355                 360                 365             


Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr Asn 
    370                 375                 380                 


Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp Cys His 
385                 390                 395                 400 


Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg Leu Leu 
                405                 410                 415     


Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly Gln Val 
            420                 425                 430         


Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr Arg Asp 
        435                 440                 445             


His Leu Gly Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala Gly Gly 
    450                 455                 460                 


Ser Trp Asp Leu Ala Val Gln Glu Arg Ala Ala 
465                 470                 475 


<210>  11
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg 
385                 390                 395         


<210>  12
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  12

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys 
385                 390                 395     


<210>  13
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  13

Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp 
1               5                   10                  15      


Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn 
            20                  25                  30          


Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe 
        35                  40                  45              


Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu 
    50                  55                  60                  


Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp 
65                  70                  75                  80  


Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe 
                85                  90                  95      


Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu 
            100                 105                 110         


Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser 
        115                 120                 125             


Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe 
    130                 135                 140                 


Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu 
145                 150                 155                 160 


Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr 
                165                 170                 175     


Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe 
            180                 185                 190         


Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile 
        195                 200                 205             


Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg 
    210                 215                 220                 


Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe 
225                 230                 235                 240 


Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu 
                245                 250                 255     


Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly 
            260                 265                 270         


Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe 
        275                 280                 285             


Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile 
    290                 295                 300                 


Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys 
305                 310                 315                 320 


Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe 
                325                 330                 335     


Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu 
            340                 345                 350         


Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn 
        355                 360                 365             


Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp Cys His Leu Ala Tyr 
    370                 375                 380                 


Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln 
385                 390                 395                 400 


Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly Gln Val Val Pro Ala 
                405                 410                 415     


Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr Arg Asp His Leu Gly 
            420                 425                 430         


Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala Gly Gly Ser Trp Asp 
        435                 440                 445             


Leu Ala Val Gln Glu Arg Ala Ala Arg Ser Gln Cys Thr Tyr Ser Asn 
    450                 455                 460                 


Pro Glu Gly Thr Val Val Leu Ala Cys Asp Gln Ala Gln Cys Arg Trp 
465                 470                 475                 480 


Leu Asn Val Gln Leu Ser Pro Gln Gln Gly Ser Leu Gly Leu Gln Tyr 
                485                 490                 495     


Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser Ser Cys Gly Ser Leu Arg 
            500                 505                 510         


Leu Thr Val Ser Ile Glu Ala Arg Ala Ala Gly Pro 
        515                 520                 


<210>  14
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp 
1               5                   10                  15      


Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn 
            20                  25                  30          


Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe 
        35                  40                  45              


Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu 
    50                  55                  60                  


Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp 
65                  70                  75                  80  


Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe 
                85                  90                  95      


Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu 
            100                 105                 110         


Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser 
        115                 120                 125             


Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe 
    130                 135                 140                 


Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu 
145                 150                 155                 160 


Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr 
                165                 170                 175     


Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe 
            180                 185                 190         


Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile 
        195                 200                 205             


Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg 
    210                 215                 220                 


Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe 
225                 230                 235                 240 


Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu 
                245                 250                 255     


Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly 
            260                 265                 270         


Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe 
        275                 280                 285             


Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile 
    290                 295                 300                 


Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys 
305                 310                 315                 320 


Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe 
                325                 330                 335     


Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu 
            340                 345                 350         


Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn 
        355                 360                 365             


Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp Cys His Leu Ala Tyr 
    370                 375                 380                 


Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln 
385                 390                 395                 400 


Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly Gln Val Val Pro Ala 
                405                 410                 415     


Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr Arg Asp His Leu Gly 
            420                 425                 430         


Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala Gly Gly Ser Trp Asp 
        435                 440                 445             


Leu Ala Val Gln Glu Arg Ala Ala 
    450                 455     


<210>  15
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe 
            20                  25                  30          


Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr 
        35                  40                  45              


Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr 
    50                  55                  60                  


Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asn 
65                  70                  75                  80  


Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg 
                85                  90                  95      


Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr 
            100                 105                 110         


Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe 
        115                 120                 125             


Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala 
    130                 135                 140                 


Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg 
145                 150                 155                 160 


Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln 
                165                 170                 175     


Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser 
            180                 185                 190         


Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln 
        195                 200                 205             


Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser 
    210                 215                 220                 


Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys 
225                 230                 235                 240 


Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu 
                245                 250                 255     


Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp 
            260                 265                 270         


Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys 
        275                 280                 285             


Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala Glu 
    290                 295                 300                 


Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr 
305                 310                 315                 320 


Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu 
                325                 330                 335     


Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro 
            340                 345                 350         


Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys 
        355                 360                 365             


Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr Asn 
    370                 375                 380                 


Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp Cys His 
385                 390                 395                 400 


Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg Leu Leu 
                405                 410                 415     


Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly Gln Val 
            420                 425                 430         


Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr Arg Asp 
        435                 440                 445             


His Leu Gly Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala Gly Gly 
    450                 455                 460                 


Ser Trp Asp Leu Ala Val Gln Glu Arg Ala Ala Arg Ser Gln Cys Thr 
465                 470                 475                 480 


Tyr Ser Asn Pro Glu Gly Thr Val Val Leu Ala Cys Asp Gln Ala Gln 
                485                 490                 495     


Cys Arg Trp Leu Asn Val Gln Leu Ser Pro Gln Gln Gly Ser Leu Gly 
            500                 505                 510         


Leu Gln Tyr Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser Ser Cys Gly 
        515                 520                 525             


Ser Leu Arg Leu Thr Val Ser Ile Glu Ala Arg Ala Ala Gly Pro 
    530                 535                 540             


<210>  16
<211>  78
<212>  PRT
<213>  Unknown

<220>
<223>  transthyretin domain

<400>  16

Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
1               5                   10                  15      


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            20                  25                  30          


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        35                  40                  45              


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    50                  55                  60                  


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
65                  70                  75              


<210>  17
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  18
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  19
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  signal sequence of Azurocidin

<400>  19

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  20
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  signal sequence of interleukin 2

<400>  20

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  21
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  signal sequence of immunoglobin G

<400>  21

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val His Ser 
            


<210>  22
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  22

Phe Gln Ser Gly Gln Val Leu Ala Ala Leu Pro Arg Thr Ser Arg Gln 
1               5                   10                  15      


Val Gln Val Leu Gln Asn Leu Thr Thr Thr Tyr Glu Ile Val Leu Trp 
            20                  25                  30          


Gln Pro Val Thr Ala Asp Leu Ile Val Lys Lys Lys Gln Val His Phe 
        35                  40                  45              


Phe Val Asn Ala Ser Asp Val Asp Asn Val Lys Ala His Leu Asn Val 
    50                  55                  60                  


Ser Gly Ile Pro Cys Ser Val Leu Leu Ala Asp Val Glu Asp Leu Ile 
65                  70                  75                  80  


Gln Gln Gln Ile Ser Asn Asp Thr Val Ser Pro Arg Ala Ser Ala Ser 
                85                  90                  95      


<210>  23
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10 Histidine residues followed by SUMO

<400>  23

Gly His His His His His His His His His His Ser Leu Gln Asp Ser 
1               5                   10                  15      


Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro 
            20                  25                  30          


Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe 
        35                  40                  45              


Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe 
    50                  55                  60                  


Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr Asp 
65                  70                  75                  80  


Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu 
                85                  90                  95      


Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly 
            100                 105                 110 


<210>  24
<211>  99
<212>  PRT
<213>  Unknown

<220>
<223>  Small Ubiquitin Modifying enzyme

<400>  24

Ser Leu Gln Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys 
1               5                   10                  15      


Pro Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly 
            20                  25                  30          


Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg 
        35                  40                  45              


Leu Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu 
    50                  55                  60                  


Thr Phe Leu Tyr Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu 
65                  70                  75                  80  


Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln 
                85                  90                  95      


Ile Gly Gly 
            


<210>  25
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Tobacco Etch Virus protease cleavage site

<400>  25

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Long Linker

<400>  26

Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
1               5                   10                  15      


Gly Ser Ser Gly 
            20  


<210>  27
<211>  225
<212>  PRT
<213>  Unknown

<220>
<223>  fragment crystallizable region

<400>  27

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  28
<211>  225
<212>  PRT
<213>  Unknown

<220>
<223>  no 1st DK LALA-PG

<400>  28

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  29
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Factor Xa protease cleavage site

<400>  29

Ala Glu Gly Arg 
1               


<210>  30
<211>  361
<212>  PRT
<213>  Unknown

<220>
<223>  mammalian maltose binding protein

<400>  30

Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Ala Ala Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Ala Ala Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu His Ala Phe Asn His Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Ala Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Val Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Ala Ala Leu 
        355                 360     


<210>  31
<211>  218
<212>  PRT
<213>  Unknown

<220>
<223>  Glutathione S transferase

<400>  31

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys 
    210                 215             


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-Tag

<400>  32

His His His His His His 
1               5       


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  33

Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
1               5                   10          


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant N2Term

<400>  34

Gly His His His His His His His His His His 
1               5                   10      


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  35

Ala Ala Ala Gln Thr Asn Ala Ala Ala Ala Ser Ser Ala Ser Leu Glu 
1               5                   10                  15      


<210>  36
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  36

Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
1               5                   10                  15      


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30      


<210>  37
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  37

Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
1               5                   10                  15      


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
            20                  25      


<210>  38
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  38

Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
1               5                   10                  15      


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
            20                  25                  30          


Gly Gly Ser Ser Ser Ser Gly Gly 
        35                  40  


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  39

Gly Gly Gly Gly 
1               


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant C2Term

<400>  40

His His His His His His His His His His 
1               5                   10  


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  41

Gly Ser Ser Gly 
1               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  42

Gly Ser Ser Gly Gly Ser Ser Gly 
1               5               


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  43

Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
1               5                   10                  15      


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 modification

<400>  44

Asp Asp Asp Asp Lys 
1               5   


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  45

Val Gly Gly Lys Ile Phe Gly Gly 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  46

Val Gly Ala Lys Ile Phe Gly Gly 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  47

Val Gly Asp Lys Ile Phe Gly Gly 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  48

Val Gly Glu Lys Ile Phe Gly Gly 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  49

Val Gly Phe Lys Ile Phe Gly Gly 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  50

Val Gly His Lys Ile Phe Gly Gly 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  51

Val Gly Ile Lys Ile Phe Gly Gly 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  52

Val Gly Lys Lys Ile Phe Gly Gly 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  53

Val Gly Leu Lys Ile Phe Gly Gly 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  54

Val Gly Met Lys Ile Phe Gly Gly 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  55

Val Gly Asn Lys Ile Phe Gly Gly 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  56

Val Gly Pro Lys Ile Phe Gly Gly 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  57

Val Gly Gln Lys Ile Phe Gly Gly 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  58

Val Gly Arg Lys Ile Phe Gly Gly 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  59

Val Gly Ser Lys Ile Phe Gly Gly 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  60

Val Gly Thr Lys Ile Phe Gly Gly 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  61

Val Gly Val Lys Ile Phe Gly Gly 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  62

Val Gly Trp Lys Ile Phe Gly Gly 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  activation peptide

<400>  63

Val Gly Tyr Lys Ile Phe Gly Gly 
1               5               


<210>  64
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPN1-HSA

<400>  64

Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys 
1               5                   10                  15      


Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala 
            20                  25                  30          


His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 
        35                  40                  45              


Phe Lys Ala Leu Val Leu Ile 
    50                  55  


<210>  65
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPN1-TEV-HSA

<400>  65

Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys 
1               5                   10                  15      


Arg Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser 
            20                  25                  30          


Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe 
        35                  40                  45              


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
    50                  55              


<210>  66
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPN1-TEV-LL-HSA

<400>  66

Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys 
1               5                   10                  15      


Arg Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser 
            20                  25                  30          


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His 
        35                  40                  45              


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
    50                  55                  60                  


Lys Ala Leu 
65          


<210>  67
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  cleavage site

<400>  67

Tyr Pro Gly Lys Phe 
1               5   


<210>  68
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  cleavage site

<400>  68

Gly Gly Lys Ile Phe Gly Gly 
1               5           


<210>  69
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  cleavage site

<400>  69

Gln Gln Lys Arg Lys Ile Val Leu 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  cleavage site

<400>  70

Val Glu Cys Phe Ala Phe Gly Ile 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  cleavage site

<400>  71

Val Ser Pro Arg Ala Ser Ala Ser 
1               5               


<210>  72
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  cleavage site

<400>  72

Ser Arg Val Arg Ala Thr 
1               5       


<210>  73
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  73

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  74
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  74

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  75
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  75

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  76
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  76

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  77
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  77

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser His His 
385                 390                 395                 400 


His His His His 
                


<210>  78
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  78

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  79
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  79

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Cys Pro Met Gly Cys Asp 
                405                 410                 415     


Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val 
            420                 425                 430         


Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr 
        435                 440                 445             


Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu 
    450                 455                 460                 


Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp 
465                 470                 475                 480 


Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser 
                485                 490                 495     


Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu 
            500                 505                 510         


Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly 
        515                 520                 525             


Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn 
    530                 535                 540                 


Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu 
545                 550                 555                 560 


Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu 
                565                 570                 575     


Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn 
            580                 585                 590         


Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu 
        595                 600                 605             


Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln 
    610                 615                 620                 


Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn 
625                 630                 635                 640 


Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu 
                645                 650                 655     


Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly 
            660                 665                 670         


Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn 
        675                 680                 685             


Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu 
    690                 695                 700                 


Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly 
705                 710                 715                 720 


Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn 
                725                 730                 735     


Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu 
            740                 745                 


<210>  80
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  80

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Cys Pro Met Gly Cys Asp 
                405                 410                 415     


Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val 
            420                 425                 430         


Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr 
        435                 440                 445             


Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu 
    450                 455                 460                 


Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp 
465                 470                 475                 480 


Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser 
                485                 490                 495     


Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu 
            500                 505                 510         


Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly 
        515                 520                 525             


Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn 
    530                 535                 540                 


Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu 
545                 550                 555                 560 


Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu 
                565                 570                 575     


Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn 
            580                 585                 590         


Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu 
        595                 600                 605             


Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln 
    610                 615                 620                 


Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn 
625                 630                 635                 640 


Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu 
                645                 650                 655     


Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly 
            660                 665                 670         


Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn 
        675                 680                 685             


Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu 
    690                 695                 700                 


Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly 
705                 710                 715                 720 


Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn 
                725                 730                 735     


Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu His His His 
            740                 745                 750         


His His His 
        755 


<210>  81
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  81

Phe Gln Ser Gly Gln Val Leu Ala Ala Leu Pro Arg Thr Ser Arg Gln 
1               5                   10                  15      


Val Gln Val Leu Gln Asn Leu Thr Thr Thr Tyr Glu Ile Val Leu Trp 
            20                  25                  30          


Gln Pro Val Thr Ala Asp Leu Ile Val Lys Lys Lys Gln Val His Phe 
        35                  40                  45              


Phe Val Asn Ala Ser Asp Val Asp Asn Val Lys Ala His Leu Asn Val 
    50                  55                  60                  


Ser Gly Ile Pro Cys Ser Val Leu Leu Ala Asp Val Glu Asp Leu Ile 
65                  70                  75                  80  


Gln Gln Gln Ile Ser Asn Asp Thr Val Ser Pro Arg Ala Ser Ala Ser 
                85                  90                  95      


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
            100                 105                 110         


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
        115                 120                 125             


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
    130                 135                 140                 


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
145                 150                 155                 160 


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
                165                 170                 175     


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
            180                 185                 190         


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
        195                 200                 205             


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
    210                 215                 220                 


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
225                 230                 235                 240 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
                245                 250                 255     


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
            260                 265                 270         


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
        275                 280                 285             


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
    290                 295                 300                 


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
305                 310                 315                 320 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
                325                 330                 335     


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
            340                 345                 350         


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
        355                 360                 365             


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
    370                 375                 380                 


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
385                 390                 395                 400 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
                405                 410                 415     


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
            420                 425                 430         


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
        435                 440                 445             


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
    450                 455                 460                 


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
465                 470                 475                 480 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
                485                 490                 


<210>  82
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  82

Phe Gln Ser Gly Gln Val Leu Ala Ala Leu Pro Arg Thr Ser Arg Gln 
1               5                   10                  15      


Val Gln Val Leu Gln Asn Leu Thr Thr Thr Tyr Glu Ile Val Leu Trp 
            20                  25                  30          


Gln Pro Val Thr Ala Asp Leu Ile Val Lys Lys Lys Gln Val His Phe 
        35                  40                  45              


Phe Val Asn Ala Ser Asp Val Asp Asn Val Lys Ala His Leu Asn Val 
    50                  55                  60                  


Ser Gly Ile Pro Cys Ser Val Leu Leu Ala Asp Val Glu Asp Leu Ile 
65                  70                  75                  80  


Gln Gln Gln Ile Ser Asn Asp Thr Val Ser Pro Arg Ala Ser Ala Ser 
                85                  90                  95      


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
            100                 105                 110         


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
        115                 120                 125             


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
    130                 135                 140                 


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
145                 150                 155                 160 


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
                165                 170                 175     


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
            180                 185                 190         


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
        195                 200                 205             


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
    210                 215                 220                 


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
225                 230                 235                 240 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
                245                 250                 255     


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
            260                 265                 270         


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
        275                 280                 285             


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
    290                 295                 300                 


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
305                 310                 315                 320 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
                325                 330                 335     


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
            340                 345                 350         


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
        355                 360                 365             


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
    370                 375                 380                 


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
385                 390                 395                 400 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
                405                 410                 415     


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
            420                 425                 430         


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
        435                 440                 445             


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
    450                 455                 460                 


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
465                 470                 475                 480 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser His His 
                485                 490                 495     


His His His His 
            500 


<210>  83
<211>  1091
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  83

Phe Gln Ser Gly Gln Val Leu Ala Ala Leu Pro Arg Thr Ser Arg Gln 
1               5                   10                  15      


Val Gln Val Leu Gln Asn Leu Thr Thr Thr Tyr Glu Ile Val Leu Trp 
            20                  25                  30          


Gln Pro Val Thr Ala Asp Leu Ile Val Lys Lys Lys Gln Val His Phe 
        35                  40                  45              


Phe Val Asn Ala Ser Asp Val Asp Asn Val Lys Ala His Leu Asn Val 
    50                  55                  60                  


Ser Gly Ile Pro Cys Ser Val Leu Leu Ala Asp Val Glu Asp Leu Ile 
65                  70                  75                  80  


Gln Gln Gln Ile Ser Asn Asp Thr Val Ser Pro Arg Ala Ser Ala Ser 
                85                  90                  95      


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
            100                 105                 110         


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
        115                 120                 125             


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
    130                 135                 140                 


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
145                 150                 155                 160 


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
                165                 170                 175     


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
            180                 185                 190         


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
        195                 200                 205             


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
    210                 215                 220                 


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
225                 230                 235                 240 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
                245                 250                 255     


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
            260                 265                 270         


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
        275                 280                 285             


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
    290                 295                 300                 


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
305                 310                 315                 320 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
                325                 330                 335     


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
            340                 345                 350         


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
        355                 360                 365             


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
    370                 375                 380                 


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
385                 390                 395                 400 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
                405                 410                 415     


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
            420                 425                 430         


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
        435                 440                 445             


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
    450                 455                 460                 


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
465                 470                 475                 480 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
                485                 490                 495     


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
            500                 505                 510         


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
        515                 520                 525             


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
    530                 535                 540                 


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
545                 550                 555                 560 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
                565                 570                 575     


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
            580                 585                 590         


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
        595                 600                 605             


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
    610                 615                 620                 


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
625                 630                 635                 640 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
                645                 650                 655     


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
            660                 665                 670         


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
        675                 680                 685             


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
    690                 695                 700                 


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
705                 710                 715                 720 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
                725                 730                 735     


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
            740                 745                 750         


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
        755                 760                 765             


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
    770                 775                 780                 


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
785                 790                 795                 800 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
                805                 810                 815     


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
            820                 825                 830         


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
        835                 840                 845             


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
    850                 855                 860                 


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
865                 870                 875                 880 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
                885                 890                 895     


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
            900                 905                 910         


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
        915                 920                 925             


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
    930                 935                 940                 


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
945                 950                 955                 960 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
                965                 970                 975     


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
            980                 985                 990         


Cys Phe Ser Ala Leu Glu Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe 
        995                 1000                 1005             


Asn Ala  Glu Thr Phe Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser 
    1010                 1015                 1020             


Glu Lys  Glu Arg Gln Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu 
    1025                 1030                 1035             


Val Lys  His Lys Pro Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val 
    1040                 1045                 1050             


Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp 
    1055                 1060                 1065             


Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala 
    1070                 1075                 1080             


Ala Ser  Gln Ala Ala Leu Gly  Leu 
    1085                 1090     


<210>  84
<211>  845
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  84

Phe Gln Ser Gly Gln Val Leu Ala Ala Leu Pro Arg Thr Ser Arg Gln 
1               5                   10                  15      


Val Gln Val Leu Gln Asn Leu Thr Thr Thr Tyr Glu Ile Val Leu Trp 
            20                  25                  30          


Gln Pro Val Thr Ala Asp Leu Ile Val Lys Lys Lys Gln Val His Phe 
        35                  40                  45              


Phe Val Asn Ala Ser Asp Val Asp Asn Val Lys Ala His Leu Asn Val 
    50                  55                  60                  


Ser Gly Ile Pro Cys Ser Val Leu Leu Ala Asp Val Glu Asp Leu Ile 
65                  70                  75                  80  


Gln Gln Gln Ile Ser Asn Asp Thr Val Ser Pro Arg Ala Ser Ala Ser 
                85                  90                  95      


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
            100                 105                 110         


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
        115                 120                 125             


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
    130                 135                 140                 


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
145                 150                 155                 160 


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
                165                 170                 175     


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
            180                 185                 190         


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
        195                 200                 205             


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
    210                 215                 220                 


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
225                 230                 235                 240 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
                245                 250                 255     


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
            260                 265                 270         


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
        275                 280                 285             


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
    290                 295                 300                 


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
305                 310                 315                 320 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
                325                 330                 335     


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
            340                 345                 350         


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
        355                 360                 365             


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
    370                 375                 380                 


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
385                 390                 395                 400 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
                405                 410                 415     


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
            420                 425                 430         


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
        435                 440                 445             


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
    450                 455                 460                 


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
465                 470                 475                 480 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
                485                 490                 495     


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Cys Pro Met Gly Cys Asp 
            500                 505                 510         


Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val 
        515                 520                 525             


Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr 
    530                 535                 540                 


Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu 
545                 550                 555                 560 


Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp 
                565                 570                 575     


Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser 
            580                 585                 590         


Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu 
        595                 600                 605             


Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly 
    610                 615                 620                 


Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn 
625                 630                 635                 640 


Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu 
                645                 650                 655     


Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu 
            660                 665                 670         


Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn 
        675                 680                 685             


Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu 
    690                 695                 700                 


Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln 
705                 710                 715                 720 


Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn 
                725                 730                 735     


Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu 
            740                 745                 750         


Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly 
        755                 760                 765             


Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn 
    770                 775                 780                 


Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu 
785                 790                 795                 800 


Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly 
                805                 810                 815     


Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn 
            820                 825                 830         


Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu 
        835                 840                 845 


<210>  85
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  85

Phe Gln Ser Gly Gln Val Leu Ala Ala Leu Pro Arg Thr Ser Arg Gln 
1               5                   10                  15      


Val Gln Val Leu Gln Asn Leu Thr Thr Thr Tyr Glu Ile Val Leu Trp 
            20                  25                  30          


Gln Pro Val Thr Ala Asp Leu Ile Val Lys Lys Lys Gln Val His Phe 
        35                  40                  45              


Phe Val Asn Ala Ser Asp Val Asp Asn Val Lys Ala His Leu Asn Val 
    50                  55                  60                  


Ser Gly Ile Pro Cys Ser Val Leu Leu Ala Asp Val Glu Asp Leu Ile 
65                  70                  75                  80  


Gln Gln Gln Ile Ser Asn Asp Thr Val Ser Pro Arg Ala Ser Ala Ser 
                85                  90                  95      


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
            100                 105                 110         


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
        115                 120                 125             


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
    130                 135                 140                 


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
145                 150                 155                 160 


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
                165                 170                 175     


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
            180                 185                 190         


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
        195                 200                 205             


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
    210                 215                 220                 


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
225                 230                 235                 240 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
                245                 250                 255     


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
            260                 265                 270         


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
        275                 280                 285             


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
    290                 295                 300                 


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
305                 310                 315                 320 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
                325                 330                 335     


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
            340                 345                 350         


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
        355                 360                 365             


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
    370                 375                 380                 


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
385                 390                 395                 400 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
                405                 410                 415     


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
            420                 425                 430         


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
        435                 440                 445             


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
    450                 455                 460                 


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
465                 470                 475                 480 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
                485                 490                 495     


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Cys Pro Met Gly Cys Asp 
            500                 505                 510         


Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val 
        515                 520                 525             


Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr 
    530                 535                 540                 


Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu 
545                 550                 555                 560 


Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp 
                565                 570                 575     


Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser 
            580                 585                 590         


Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu 
        595                 600                 605             


Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly 
    610                 615                 620                 


Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn 
625                 630                 635                 640 


Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu 
                645                 650                 655     


Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu 
            660                 665                 670         


Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn 
        675                 680                 685             


Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu 
    690                 695                 700                 


Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln 
705                 710                 715                 720 


Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn 
                725                 730                 735     


Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu 
            740                 745                 750         


Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly 
        755                 760                 765             


Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn 
    770                 775                 780                 


Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu 
785                 790                 795                 800 


Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly 
                805                 810                 815     


Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn 
            820                 825                 830         


Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu His His His 
        835                 840                 845             


His His His 
    850     


<210>  86
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  86

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
            500                 505                 


<210>  87
<211>  1106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  87

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser Ser 
            500                 505                 510         


Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val 
        515                 520                 525             


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
    530                 535                 540                 


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
545                 550                 555                 560 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
                565                 570                 575     


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            580                 585                 590         


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
        595                 600                 605             


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    610                 615                 620                 


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
625                 630                 635                 640 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
                645                 650                 655     


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            660                 665                 670         


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
        675                 680                 685             


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
    690                 695                 700                 


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
705                 710                 715                 720 


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
                725                 730                 735     


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
            740                 745                 750         


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
        755                 760                 765             


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
    770                 775                 780                 


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
785                 790                 795                 800 


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
                805                 810                 815     


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
            820                 825                 830         


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
        835                 840                 845             


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
    850                 855                 860                 


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
865                 870                 875                 880 


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
                885                 890                 895     


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
            900                 905                 910         


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
        915                 920                 925             


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
    930                 935                 940                 


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
945                 950                 955                 960 


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
                965                 970                 975     


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
            980                 985                 990         


Arg Val Thr Lys Cys Cys Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys 
        995                 1000                 1005             


Phe Ser  Ala Leu Glu Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe 
    1010                 1015                 1020             


Asn Ala  Glu Thr Phe Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser 
    1025                 1030                 1035             


Glu Lys  Glu Arg Gln Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu 
    1040                 1045                 1050             


Val Lys  His Lys Pro Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val 
    1055                 1060                 1065             


Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp 
    1070                 1075                 1080             


Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala 
    1085                 1090                 1095             


Ala Ser  Gln Ala Ala Leu Gly  Leu 
    1100                 1105     


<210>  88
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  88

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
            420                 425                 430     


<210>  89
<211>  1028
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  89

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser 
        435                 440                 445             


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
    450                 455                 460                 


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
465                 470                 475                 480 


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
                485                 490                 495     


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
            500                 505                 510         


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
        515                 520                 525             


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
    530                 535                 540                 


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
545                 550                 555                 560 


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
                565                 570                 575     


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
            580                 585                 590         


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
        595                 600                 605             


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
    610                 615                 620                 


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
625                 630                 635                 640 


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
                645                 650                 655     


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
            660                 665                 670         


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
        675                 680                 685             


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
    690                 695                 700                 


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
705                 710                 715                 720 


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
                725                 730                 735     


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
            740                 745                 750         


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
        755                 760                 765             


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
    770                 775                 780                 


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
785                 790                 795                 800 


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
                805                 810                 815     


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
            820                 825                 830         


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
        835                 840                 845             


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
    850                 855                 860                 


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
865                 870                 875                 880 


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
                885                 890                 895     


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
            900                 905                 910         


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
        915                 920                 925             


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
    930                 935                 940                 


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
945                 950                 955                 960 


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
                965                 970                 975     


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
            980                 985                 990         


Asp Phe Ala Ala Phe Val Glu Lys  Cys Cys Lys Ala Asp  Asp Lys Glu 
        995                 1000                 1005             


Thr Cys  Phe Ala Glu Glu Gly  Lys Lys Leu Val Ala  Ala Ser Gln 
    1010                 1015                 1020             


Ala Ala  Leu Gly Leu 
    1025             


<210>  90
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  90

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


<210>  91
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  91

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys 
                325                 330                 335     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            340                 345                 350         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
        355                 360                 365             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    370                 375                 380                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
385                 390                 395                 400 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                405                 410                 415     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            420                 425                 430         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        435                 440                 445             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    450                 455                 460                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
465                 470                 475                 480 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                485                 490                 495     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            500                 505                 510         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        515                 520                 525             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    530                 535                 540                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
545                 550                 555                 560 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                565                 570                 575     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            580                 585                 590         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        595                 600                 605             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    610                 615                 620                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
625                 630                 635                 640 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                645                 650                 655     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            660                 665                 670         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        675                 680                 685             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    690                 695                 700                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
705                 710                 715                 720 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                725                 730                 735     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            740                 745                 750         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        755                 760                 765             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    770                 775                 780                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
785                 790                 795                 800 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                805                 810                 815     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            820                 825                 830         


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        835                 840                 845             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    850                 855                 860                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
865                 870                 875                 880 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                885                 890                 895     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            900                 905                 910         


Ala Ala Leu Gly Leu 
        915         


<210>  92
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  92

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  93
<211>  1010
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  93

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val 
            420                 425                 430         


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
        435                 440                 445             


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
    450                 455                 460                 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
465                 470                 475                 480 


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
                485                 490                 495     


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
            500                 505                 510         


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
        515                 520                 525             


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
    530                 535                 540                 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
545                 550                 555                 560 


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
                565                 570                 575     


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
            580                 585                 590         


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
        595                 600                 605             


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
    610                 615                 620                 


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
625                 630                 635                 640 


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
                645                 650                 655     


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
            660                 665                 670         


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
        675                 680                 685             


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
    690                 695                 700                 


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
705                 710                 715                 720 


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
                725                 730                 735     


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
            740                 745                 750         


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
        755                 760                 765             


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
    770                 775                 780                 


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
785                 790                 795                 800 


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
                805                 810                 815     


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
            820                 825                 830         


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
        835                 840                 845             


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
    850                 855                 860                 


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
865                 870                 875                 880 


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
                885                 890                 895     


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
            900                 905                 910         


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
        915                 920                 925             


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
    930                 935                 940                 


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
945                 950                 955                 960 


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
                965                 970                 975     


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
            980                 985                 990         


Phe Ala Glu Glu Gly Lys Lys Leu  Val Ala Ala Ser Gln  Ala Ala Leu 
        995                 1000                 1005             


Gly Leu  
    1010 


<210>  94
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  94

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            420                 425                 430         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        435                 440                 445             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    450                 455                 460                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
465                 470                 475                 480 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                485                 490                 495     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            500                 505                 510         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
        515                 520                 525             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    530                 535                 540                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
545                 550                 555                 560 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                565                 570                 575     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            580                 585                 590         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        595                 600                 605             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    610                 615                 620                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
625                 630                 635                 640 


Gly Lys 
        


<210>  95
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  95

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Gly His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ala Glu 
385                 390                 395                 400 


Gly Arg Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Thr His 
                405                 410                 415     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
            420                 425                 430         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        435                 440                 445             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    450                 455                 460                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
465                 470                 475                 480 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                485                 490                 495     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            500                 505                 510         


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
        515                 520                 525             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    530                 535                 540                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
545                 550                 555                 560 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                565                 570                 575     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            580                 585                 590         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        595                 600                 605             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    610                 615                 620                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630                 635                 


<210>  96
<211>  999
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  96

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Gly His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Val Glu 
385                 390                 395                 400 


Gly Arg Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala 
                405                 410                 415     


His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 
            420                 425                 430         


Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys 
        435                 440                 445             


Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 
    450                 455                 460                 


Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 
465                 470                 475                 480 


His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 
                485                 490                 495     


Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 
            500                 505                 510         


Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 
        515                 520                 525             


Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 
    530                 535                 540                 


Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 
545                 550                 555                 560 


Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 
                565                 570                 575     


Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 
            580                 585                 590         


Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 
        595                 600                 605             


Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 
    610                 615                 620                 


Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 
625                 630                 635                 640 


Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 
                645                 650                 655     


Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 
            660                 665                 670         


Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 
        675                 680                 685             


Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 
    690                 695                 700                 


Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 
705                 710                 715                 720 


Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 
                725                 730                 735     


Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 
            740                 745                 750         


Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 
        755                 760                 765             


Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 
    770                 775                 780                 


Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 
785                 790                 795                 800 


Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 
                805                 810                 815     


Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 
            820                 825                 830         


Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 
        835                 840                 845             


Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 
    850                 855                 860                 


Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 
865                 870                 875                 880 


Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 
                885                 890                 895     


Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 
            900                 905                 910         


Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 
        915                 920                 925             


Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 
    930                 935                 940                 


Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 
945                 950                 955                 960 


Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 
                965                 970                 975     


Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 
            980                 985                 990         


Ser Gln Ala Ala Leu Gly Leu 
        995                 


<210>  97
<211>  1379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  97

Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Ala Ala Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Ala Ala Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu His Ala Phe Asn His Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Ala Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Val Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Ala Ala Leu Ala Ala Ala Gln Thr Asn Ala 
        355                 360                 365             


Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln Gly 
    370                 375                 380                 


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
385                 390                 395                 400 


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
                405                 410                 415     


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
            420                 425                 430         


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
        435                 440                 445             


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
    450                 455                 460                 


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
465                 470                 475                 480 


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
                485                 490                 495     


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
            500                 505                 510         


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
        515                 520                 525             


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
    530                 535                 540                 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
545                 550                 555                 560 


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
                565                 570                 575     


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
            580                 585                 590         


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
        595                 600                 605             


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
    610                 615                 620                 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
625                 630                 635                 640 


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
                645                 650                 655     


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
            660                 665                 670         


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
        675                 680                 685             


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
    690                 695                 700                 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
                725                 730                 735     


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
            740                 745                 750         


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
        755                 760                 765             


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
    770                 775                 780                 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
785                 790                 795                 800 


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
                805                 810                 815     


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
            820                 825                 830         


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
        835                 840                 845             


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
    850                 855                 860                 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
865                 870                 875                 880 


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
                885                 890                 895     


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
            900                 905                 910         


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
        915                 920                 925             


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
    930                 935                 940                 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
945                 950                 955                 960 


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
                965                 970                 975     


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
            980                 985                 990         


Lys Cys Ala Ser Leu Gln Lys Phe  Gly Glu Arg Ala Phe  Lys Ala Trp 
        995                 1000                 1005             


Ala Val  Ala Arg Leu Ser Gln  Arg Phe Pro Lys Ala  Glu Phe Ala 
    1010                 1015                 1020             


Glu Val  Ser Lys Leu Val Thr  Asp Leu Thr Lys Val  His Thr Glu 
    1025                 1030                 1035             


Cys Cys  His Gly Asp Leu Leu  Glu Cys Ala Asp Asp  Arg Ala Asp 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Ile Cys Glu  Asn Gln Asp Ser Ile  Ser Ser Lys 
    1055                 1060                 1065             


Leu Lys  Glu Cys Cys Glu Lys  Pro Leu Leu Glu Lys  Ser His Cys 
    1070                 1075                 1080             


Ile Ala  Glu Val Glu Asn Asp  Glu Met Pro Ala Asp  Leu Pro Ser 
    1085                 1090                 1095             


Leu Ala  Ala Asp Phe Val Glu  Ser Lys Asp Val Cys  Lys Asn Tyr 
    1100                 1105                 1110             


Ala Glu  Ala Lys Asp Val Phe  Leu Gly Met Phe Leu  Tyr Glu Tyr 
    1115                 1120                 1125             


Ala Arg  Arg His Pro Asp Tyr  Ser Val Val Leu Leu  Leu Arg Leu 
    1130                 1135                 1140             


Ala Lys  Thr Tyr Glu Thr Thr  Leu Glu Lys Cys Cys  Ala Ala Ala 
    1145                 1150                 1155             


Asp Pro  His Glu Cys Tyr Ala  Lys Val Phe Asp Glu  Phe Lys Pro 
    1160                 1165                 1170             


Leu Val  Glu Glu Pro Gln Asn  Leu Ile Lys Gln Asn  Cys Glu Leu 
    1175                 1180                 1185             


Phe Glu  Gln Leu Gly Glu Tyr  Lys Phe Gln Asn Ala  Leu Leu Val 
    1190                 1195                 1200             


Arg Tyr  Thr Lys Lys Val Pro  Gln Val Ser Thr Pro  Thr Leu Val 
    1205                 1210                 1215             


Glu Val  Ser Arg Asn Leu Gly  Lys Val Gly Ser Lys  Cys Cys Lys 
    1220                 1225                 1230             


His Pro  Glu Ala Lys Arg Met  Pro Cys Ala Glu Asp  Tyr Leu Ser 
    1235                 1240                 1245             


Val Val  Leu Asn Gln Leu Cys  Val Leu His Glu Lys  Thr Pro Val 
    1250                 1255                 1260             


Ser Asp  Arg Val Thr Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg 
    1265                 1270                 1275             


Arg Pro  Cys Phe Ser Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro 
    1280                 1285                 1290             


Lys Glu  Phe Asn Ala Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys 
    1295                 1300                 1305             


Thr Leu  Ser Glu Lys Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu 
    1310                 1315                 1320             


Val Glu  Leu Val Lys His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu 
    1325                 1330                 1335             


Lys Ala  Val Met Asp Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys 
    1340                 1345                 1350             


Lys Ala  Asp Asp Lys Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys 
    1355                 1360                 1365             


Leu Val  Ala Ala Ser Gln Ala  Ala Leu Gly Leu 
    1370                 1375                 


<210>  98
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  98

Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Ala Ala Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Ala Ala Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu His Ala Phe Asn His Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Ala Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Val Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Ala Ala Leu Ala Ala Ala Gln Thr Asn Ala 
        355                 360                 365             


Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln Gly 
    370                 375                 380                 


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
385                 390                 395                 400 


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
                405                 410                 415     


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
            420                 425                 430         


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
        435                 440                 445             


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
    450                 455                 460                 


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
465                 470                 475                 480 


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
                485                 490                 495     


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
            500                 505                 510         


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
        515                 520                 525             


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
    530                 535                 540                 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
545                 550                 555                 560 


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
                565                 570                 575     


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
            580                 585                 590         


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
        595                 600                 605             


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
    610                 615                 620                 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
625                 630                 635                 640 


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
                645                 650                 655     


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
            660                 665                 670         


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
        675                 680                 685             


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
    690                 695                 700                 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
                725                 730                 735     


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
            740                 745                 750         


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
        755                 760                 765             


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
    770                 775                 780         


<210>  99
<211>  1236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  99

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ala Ala Ala Gln Thr Asn 
    210                 215                 220                 


Ala Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu 
                245                 250                 255     


Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile 
            260                 265                 270         


Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp 
        275                 280                 285             


His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly 
    290                 295                 300                 


Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu 
305                 310                 315                 320 


Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val 
                325                 330                 335     


Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro 
            340                 345                 350         


Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr 
        355                 360                 365             


Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe 
    370                 375                 380                 


Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro 
385                 390                 395                 400 


Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro 
                405                 410                 415     


Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu 
            420                 425                 430         


Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp 
        435                 440                 445             


Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr 
    450                 455                 460                 


Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser 
465                 470                 475                 480 


Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe 
                485                 490                 495     


Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly 
            500                 505                 510         


Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu 
        515                 520                 525             


Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu 
    530                 535                 540                 


Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His 
545                 550                 555                 560 


Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala 
                565                 570                 575     


Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly 
            580                 585                 590         


Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val 
        595                 600                 605             


Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val 
    610                 615                 620                 


Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly 
625                 630                 635                 640 


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser 
                645                 650                 655     


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
            660                 665                 670         


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
        675                 680                 685             


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
    690                 695                 700                 


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
705                 710                 715                 720 


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
                725                 730                 735     


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
            740                 745                 750         


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
        755                 760                 765             


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
    770                 775                 780                 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
785                 790                 795                 800 


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
                805                 810                 815     


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
            820                 825                 830         


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
        835                 840                 845             


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
    850                 855                 860                 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
865                 870                 875                 880 


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
                885                 890                 895     


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
            900                 905                 910         


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
        915                 920                 925             


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
    930                 935                 940                 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
945                 950                 955                 960 


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
                965                 970                 975     


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
            980                 985                 990         


Ser Val Val Leu Leu Leu Arg Leu  Ala Lys Thr Tyr Glu  Thr Thr Leu 
        995                 1000                 1005             


Glu Lys  Cys Cys Ala Ala Ala  Asp Pro His Glu Cys  Tyr Ala Lys 
    1010                 1015                 1020             


Val Phe  Asp Glu Phe Lys Pro  Leu Val Glu Glu Pro  Gln Asn Leu 
    1025                 1030                 1035             


Ile Lys  Gln Asn Cys Glu Leu  Phe Glu Gln Leu Gly  Glu Tyr Lys 
    1040                 1045                 1050             


Phe Gln  Asn Ala Leu Leu Val  Arg Tyr Thr Lys Lys  Val Pro Gln 
    1055                 1060                 1065             


Val Ser  Thr Pro Thr Leu Val  Glu Val Ser Arg Asn  Leu Gly Lys 
    1070                 1075                 1080             


Val Gly  Ser Lys Cys Cys Lys  His Pro Glu Ala Lys  Arg Met Pro 
    1085                 1090                 1095             


Cys Ala  Glu Asp Tyr Leu Ser  Val Val Leu Asn Gln  Leu Cys Val 
    1100                 1105                 1110             


Leu His  Glu Lys Thr Pro Val  Ser Asp Arg Val Thr  Lys Cys Cys 
    1115                 1120                 1125             


Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys Phe Ser  Ala Leu Glu 
    1130                 1135                 1140             


Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe Asn Ala  Glu Thr Phe 
    1145                 1150                 1155             


Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser Glu Lys  Glu Arg Gln 
    1160                 1165                 1170             


Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu Val Lys  His Lys Pro 
    1175                 1180                 1185             


Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val Met Asp  Asp Phe Ala 
    1190                 1195                 1200             


Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp Asp Lys  Glu Thr Cys 
    1205                 1210                 1215             


Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala Ala Ser  Gln Ala Ala 
    1220                 1225                 1230             


Leu Gly  Leu 
    1235     


<210>  100
<211>  874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  100

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                405                 410                 415     


Ser Gly Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe Cys 
            420                 425                 430         


Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr 
        435                 440                 445             


Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg 
    450                 455                 460                 


Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asn Thr 
465                 470                 475                 480 


Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu 
                485                 490                 495     


Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn 
            500                 505                 510         


Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn 
        515                 520                 525             


Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala Leu 
    530                 535                 540                 


Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg 
545                 550                 555                 560 


Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln Asn 
                565                 570                 575     


Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser Leu 
            580                 585                 590         


Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly 
        595                 600                 605             


Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn 
    610                 615                 620                 


Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys Leu 
625                 630                 635                 640 


Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu Ser 
                645                 650                 655     


Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn 
            660                 665                 670         


Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys Leu 
        675                 680                 685             


Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala Glu Gly 
    690                 695                 700                 


Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn 
705                 710                 715                 720 


Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu 
                725                 730                 735     


Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro Ala 
            740                 745                 750         


Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn 
        755                 760                 765             


Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr Asn Leu 
    770                 775                 780                 


Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp Cys His Leu 
785                 790                 795                 800 


Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg Leu Leu Asn 
                805                 810                 815     


Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly Gln Val Val 
            820                 825                 830         


Pro Ala Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr Arg Asp His 
        835                 840                 845             


Leu Gly Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala Gly Gly Ser 
    850                 855                 860                 


Trp Asp Leu Ala Val Gln Glu Arg Ala Ala 
865                 870                 


<210>  101
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  101

Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp 
1               5                   10                  15      


Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn 
            20                  25                  30          


Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe 
        35                  40                  45              


Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu 
    50                  55                  60                  


Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp 
65                  70                  75                  80  


Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe 
                85                  90                  95      


Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu 
            100                 105                 110         


Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser 
        115                 120                 125             


Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe 
    130                 135                 140                 


Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu 
145                 150                 155                 160 


Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr 
                165                 170                 175     


Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe 
            180                 185                 190         


Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile 
        195                 200                 205             


Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg 
    210                 215                 220                 


Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe 
225                 230                 235                 240 


Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu 
                245                 250                 255     


Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly 
            260                 265                 270         


Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe 
        275                 280                 285             


Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile 
    290                 295                 300                 


Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys 
305                 310                 315                 320 


Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe 
                325                 330                 335     


Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu 
            340                 345                 350         


Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn 
        355                 360                 365             


Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp Cys His Leu Ala Tyr 
    370                 375                 380                 


Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln 
385                 390                 395                 400 


Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly Gln Val Val Pro Ala 
                405                 410                 415     


Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr Arg Asp His Leu Gly 
            420                 425                 430         


Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala Gly Gly Ser Trp Asp 
        435                 440                 445             


Leu Ala Val Gln Glu Arg Ala Ala 
    450                 455     


<210>  102
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  102

Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp 
1               5                   10                  15      


Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn 
            20                  25                  30          


Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe 
        35                  40                  45              


Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu 
    50                  55                  60                  


Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp 
65                  70                  75                  80  


Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe 
                85                  90                  95      


Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu 
            100                 105                 110         


Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser 
        115                 120                 125             


Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe 
    130                 135                 140                 


Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu 
145                 150                 155                 160 


Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr 
                165                 170                 175     


Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe 
            180                 185                 190         


Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile 
        195                 200                 205             


Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg 
    210                 215                 220                 


Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe 
225                 230                 235                 240 


Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu 
                245                 250                 255     


Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly 
            260                 265                 270         


Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe 
        275                 280                 285             


Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile 
    290                 295                 300                 


Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys 
305                 310                 315                 320 


Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe 
                325                 330                 335     


Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu 
            340                 345                 350         


Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn 
        355                 360                 365             


Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp Cys His Leu Ala Tyr 
    370                 375                 380                 


Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln 
385                 390                 395                 400 


Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly Gln Val Val Pro Ala 
                405                 410                 415     


Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr Arg Asp His Leu Gly 
            420                 425                 430         


Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala Gly Gly Ser Trp Asp 
        435                 440                 445             


Leu Ala Val Gln Glu Arg Ala Ala Arg Ser Gln Cys Thr Tyr Ser Asn 
    450                 455                 460                 


Pro Glu Gly Thr Val Val Leu Ala Cys Asp Gln Ala Gln Cys Arg Trp 
465                 470                 475                 480 


Leu Asn Val Gln Leu Ser Pro Gln Gln Gly Ser Leu Gly Leu Gln Tyr 
                485                 490                 495     


Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser Ser Cys Gly Ser Leu Arg 
            500                 505                 510         


Leu Thr Val Ser Ile Glu Ala Arg Ala Ala Gly Pro 
        515                 520                 


<210>  103
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  103

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Arg His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asp Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


<210>  104
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  104

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Ser His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Arg Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


<210>  105
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  105

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Lys His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


<210>  106
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  106

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Ser His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Arg Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Lys Phe Gln Asp Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Lys 
305                 310                 315                 320 


<210>  107
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  107

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Arg His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln His Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asp Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


<210>  108
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  108

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Arg His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Lys Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asp Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


<210>  109
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  109

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
385                 390                 395                 400 


Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly Val Arg 
                405                 410                 415     


Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln 
            420                 425                 430         


Leu Gln Arg Gly Pro Ala 
        435             


<210>  110
<211>  1035
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  110

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
385                 390                 395                 400 


Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly Val Arg 
                405                 410                 415     


Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln 
            420                 425                 430         


Leu Gln Arg Gly Pro Ala Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
        435                 440                 445             


Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu 
    450                 455                 460                 


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
465                 470                 475                 480 


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
                485                 490                 495     


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
            500                 505                 510         


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
        515                 520                 525             


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
    530                 535                 540                 


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
545                 550                 555                 560 


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
                565                 570                 575     


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
            580                 585                 590         


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
        595                 600                 605             


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
    610                 615                 620                 


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
625                 630                 635                 640 


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
                645                 650                 655     


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
            660                 665                 670         


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
        675                 680                 685             


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
    690                 695                 700                 


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
705                 710                 715                 720 


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
                725                 730                 735     


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
            740                 745                 750         


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
        755                 760                 765             


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
    770                 775                 780                 


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
785                 790                 795                 800 


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
                805                 810                 815     


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
            820                 825                 830         


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
        835                 840                 845             


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
    850                 855                 860                 


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
865                 870                 875                 880 


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
                885                 890                 895     


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
            900                 905                 910         


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
        915                 920                 925             


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
    930                 935                 940                 


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
945                 950                 955                 960 


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
                965                 970                 975     


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
            980                 985                 990         


Gln Leu Lys Ala Val Met Asp Asp  Phe Ala Ala Phe Val  Glu Lys Cys 
        995                 1000                 1005             


Cys Lys  Ala Asp Asp Lys Glu  Thr Cys Phe Ala Glu  Glu Gly Lys 
    1010                 1015                 1020             


Lys Leu  Val Ala Ala Ser Gln  Ala Ala Leu Gly Leu  
    1025                 1030                 1035 


<210>  111
<211>  914
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  111

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
385                 390                 395                 400 


Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly Val Arg 
                405                 410                 415     


Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln 
            420                 425                 430         


Leu Gln Arg Gly Pro Ala Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
        435                 440                 445             


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Cys Pro Met Gly Cys Asp 
    450                 455                 460                 


Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val 
465                 470                 475                 480 


Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr 
                485                 490                 495     


Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu 
            500                 505                 510         


Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp 
        515                 520                 525             


Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser 
    530                 535                 540                 


Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu 
545                 550                 555                 560 


Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly 
                565                 570                 575     


Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn 
            580                 585                 590         


Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu 
        595                 600                 605             


Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu 
    610                 615                 620                 


Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn 
625                 630                 635                 640 


Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu 
                645                 650                 655     


Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln 
            660                 665                 670         


Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn 
        675                 680                 685             


Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu 
    690                 695                 700                 


Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly 
705                 710                 715                 720 


Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn 
                725                 730                 735     


Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu 
            740                 745                 750         


Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly 
        755                 760                 765             


Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn 
    770                 775                 780                 


Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu 
785                 790                 795                 800 


Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly 
                805                 810                 815     


Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn 
            820                 825                 830         


Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln 
        835                 840                 845             


Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro 
    850                 855                 860                 


Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu 
865                 870                 875                 880 


Val Cys Pro Val Thr Arg Asp His Leu Gly Phe Gln Val Thr Trp Pro 
                885                 890                 895     


Asp Glu Ser Lys Ala Gly Gly Ser Trp Asp Leu Ala Val Gln Glu Arg 
            900                 905                 910         


Ala Ala 
        


<210>  112
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  112

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
385                 390                 395                 400 


Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly Val Arg 
                405                 410                 415     


Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln 
            420                 425                 430         


Leu Gln Arg Gly Pro Ala Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
        435                 440                 445             


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Cys Pro Met Gly Cys Asp 
    450                 455                 460                 


Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val 
465                 470                 475                 480 


Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr 
                485                 490                 495     


Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu 
            500                 505                 510         


Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp 
        515                 520                 525             


Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser 
    530                 535                 540                 


Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu 
545                 550                 555                 560 


Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly 
                565                 570                 575     


Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn 
            580                 585                 590         


Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu 
        595                 600                 605             


Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu 
    610                 615                 620                 


Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn 
625                 630                 635                 640 


Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu 
                645                 650                 655     


Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln 
            660                 665                 670         


Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn 
        675                 680                 685             


Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu 
    690                 695                 700                 


Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly 
705                 710                 715                 720 


Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn 
                725                 730                 735     


Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu 
            740                 745                 750         


Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly 
        755                 760                 765             


Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn 
    770                 775                 780                 


Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu 
785                 790                 795                 800 


Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly 
                805                 810                 815     


Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn 
            820                 825                 830         


Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln 
        835                 840                 845             


Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro 
    850                 855                 860                 


Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu 
865                 870                 875                 880 


Val Cys Pro Val Thr Arg Asp His Leu Gly Phe Gln Val Thr Trp Pro 
                885                 890                 895     


Asp Glu Ser Lys Ala Gly Gly Ser Trp Asp Leu Ala Val Gln Glu Arg 
            900                 905                 910         


Ala Ala Arg Ser Gln Cys Thr Tyr Ser Asn Pro Glu Gly Thr Val Val 
        915                 920                 925             


Leu Ala Cys Asp Gln Ala Gln Cys Arg Trp Leu Asn Val Gln Leu Ser 
    930                 935                 940                 


Pro Gln Gln Gly Ser Leu Gly Leu Gln Tyr Asn Ala Ser Gln Glu Trp 
945                 950                 955                 960 


Asp Leu Arg Ser Ser Cys Gly Ser Leu Arg Leu Thr Val Ser Ile Glu 
                965                 970                 975     


Ala Arg Ala Ala Gly Pro 
            980         


<210>  113
<211>  852
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  113

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                405                 410                 415     


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly 
            420                 425                 430         


Cys Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala 
        435                 440                 445             


Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val 
    450                 455                 460                 


Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro 
465                 470                 475                 480 


Asn Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg 
                485                 490                 495     


Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr 
            500                 505                 510         


Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr 
        515                 520                 525             


Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro 
    530                 535                 540                 


Glu Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln 
545                 550                 555                 560 


Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr 
                565                 570                 575     


His Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro 
            580                 585                 590         


Glu Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser 
        595                 600                 605             


Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly 
    610                 615                 620                 


Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro 
625                 630                 635                 640 


Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln 
                645                 650                 655     


Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly 
            660                 665                 670         


Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro 
        675                 680                 685             


Ala Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr 
    690                 695                 700                 


His Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser 
705                 710                 715                 720 


Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro 
                725                 730                 735     


Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly 
            740                 745                 750         


Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser 
        755                 760                 765             


Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro 
    770                 775                 780                 


Glu Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His 
785                 790                 795                 800 


Gly Asn Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp 
                805                 810                 815     


Leu Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala 
            820                 825                 830         


Gly Pro Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys 
        835                 840                 845             


Gln Leu Val Cys 
    850         


<210>  114
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  114

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                405                 410                 415     


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly 
            420                 425                 430         


Cys Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala 
        435                 440                 445             


Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val 
    450                 455                 460                 


Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro 
465                 470                 475                 480 


Asn Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg 
                485                 490                 495     


Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr 
            500                 505                 510         


Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr 
        515                 520                 525             


Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro 
    530                 535                 540                 


Glu Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln 
545                 550                 555                 560 


Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr 
                565                 570                 575     


His Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro 
            580                 585                 590         


Glu Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser 
        595                 600                 605             


Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly 
    610                 615                 620                 


Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro 
625                 630                 635                 640 


Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln 
                645                 650                 655     


Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly 
            660                 665                 670         


Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro 
        675                 680                 685             


Ala Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr 
    690                 695                 700                 


His Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser 
705                 710                 715                 720 


Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro 
                725                 730                 735     


Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly 
            740                 745                 750         


Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser 
        755                 760                 765             


Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro 
    770                 775                 780                 


Glu Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu Ser 
785                 790                 795                 800 


His Asn Pro Leu Asp Cys Thr Ser Ser Asn Ile His Phe Ile Thr Trp 
                805                 810                 815     


Tyr Lys Glu Asn Leu His Lys Leu Glu Asp Ser Glu Glu Thr Thr Cys 
            820                 825                 830         


Ala Asn Pro Pro Ser Leu Arg Gly Val Lys Leu 
        835                 840             


<210>  115
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  115

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                405                 410                 415     


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly 
            420                 425                 430         


Cys Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala 
        435                 440                 445             


Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val 
    450                 455                 460                 


Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro 
465                 470                 475                 480 


Asn Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg 
                485                 490                 495     


Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr 
            500                 505                 510         


Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr 
        515                 520                 525             


Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro 
    530                 535                 540                 


Glu Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln 
545                 550                 555                 560 


Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr 
                565                 570                 575     


His Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro 
            580                 585                 590         


Glu Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser 
        595                 600                 605             


Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly 
    610                 615                 620                 


Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro 
625                 630                 635                 640 


Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln 
                645                 650                 655     


Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly 
            660                 665                 670         


Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro 
        675                 680                 685             


Ala Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr 
    690                 695                 700                 


His Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser 
705                 710                 715                 720 


Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro 
                725                 730                 735     


Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly 
            740                 745                 750         


Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser 
        755                 760                 765             


Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro 
    770                 775                 780                 


Glu Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Glu Leu His Ile Ser 
785                 790                 795                 800 


Ser Asp Ser Phe Leu Cys Asp Cys Gln Leu Lys Leu Trp Leu Pro Pro 
                805                 810                 815     


Trp Leu Ile Gly Arg Met Leu Gln Ala Phe Val Thr Ala Thr Cys Ala 
            820                 825                 830         


His Pro Glu Ser Leu Lys Gly Gln Ser Ile Phe Ser Val Pro Pro Glu 
        835                 840                 845             


Ser Phe Val Cys Asp Asp 
    850                 


<210>  116
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  116

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly Cys 
            420                 425                 430         


Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr 
        435                 440                 445             


Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu 
    450                 455                 460                 


Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn 
465                 470                 475                 480 


Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro 
                485                 490                 495     


Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly 
            500                 505                 510         


Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser 
        515                 520                 525             


Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu 
    530                 535                 540                 


Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly 
545                 550                 555                 560 


Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His 
                565                 570                 575     


Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu 
            580                 585                 590         


Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn 
        595                 600                 605             


Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser 
    610                 615                 620                 


Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro 
625                 630                 635                 640 


Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg 
                645                 650                 655     


Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn 
            660                 665                 670         


Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala 
        675                 680                 685             


Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His 
    690                 695                 700                 


Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn 
705                 710                 715                 720 


Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala 
                725                 730                 735     


Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser 
            740                 745                 750         


Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys 
        755                 760                 765             


Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu 
    770                 775                 780                 


Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly 
785                 790                 795                 800 


Asn Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu 
                805                 810                 815     


Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly 
            820                 825                 830         


Pro Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln 
        835                 840                 845             


Leu Val Cys 
    850     


<210>  117
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  117

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly Cys 
            420                 425                 430         


Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr 
        435                 440                 445             


Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu 
    450                 455                 460                 


Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn 
465                 470                 475                 480 


Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro 
                485                 490                 495     


Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly 
            500                 505                 510         


Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser 
        515                 520                 525             


Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu 
    530                 535                 540                 


Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly 
545                 550                 555                 560 


Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His 
                565                 570                 575     


Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu 
            580                 585                 590         


Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn 
        595                 600                 605             


Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser 
    610                 615                 620                 


Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro 
625                 630                 635                 640 


Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg 
                645                 650                 655     


Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn 
            660                 665                 670         


Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala 
        675                 680                 685             


Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His 
    690                 695                 700                 


Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn 
705                 710                 715                 720 


Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala 
                725                 730                 735     


Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser 
            740                 745                 750         


Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys 
        755                 760                 765             


Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu 
    770                 775                 780                 


Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly 
785                 790                 795                 800 


Asn Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu 
                805                 810                 815     


Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly 
            820                 825                 830         


Pro Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln 
        835                 840                 845             


Leu Val Cys Leu Ser His Asn Pro Leu Asp Cys Thr Ser Ser Asn Ile 
    850                 855                 860                 


His Phe Ile Thr Trp Tyr Lys Glu Asn Leu His Lys Leu Glu Asp Ser 
865                 870                 875                 880 


Glu Glu Thr Thr Cys Ala Asn Pro Pro Ser Leu Arg Gly Val Lys Leu 
                885                 890                 895     


<210>  118
<211>  910
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  118

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly Cys 
            420                 425                 430         


Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr 
        435                 440                 445             


Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu 
    450                 455                 460                 


Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn 
465                 470                 475                 480 


Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro 
                485                 490                 495     


Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly 
            500                 505                 510         


Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser 
        515                 520                 525             


Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu 
    530                 535                 540                 


Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly 
545                 550                 555                 560 


Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His 
                565                 570                 575     


Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu 
            580                 585                 590         


Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn 
        595                 600                 605             


Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser 
    610                 615                 620                 


Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro 
625                 630                 635                 640 


Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg 
                645                 650                 655     


Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn 
            660                 665                 670         


Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala 
        675                 680                 685             


Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His 
    690                 695                 700                 


Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn 
705                 710                 715                 720 


Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala 
                725                 730                 735     


Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser 
            740                 745                 750         


Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys 
        755                 760                 765             


Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu 
    770                 775                 780                 


Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly 
785                 790                 795                 800 


Asn Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu 
                805                 810                 815     


Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly 
            820                 825                 830         


Pro Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln 
        835                 840                 845             


Leu Val Cys Glu Leu His Ile Ser Ser Asp Ser Phe Leu Cys Asp Cys 
    850                 855                 860                 


Gln Leu Lys Leu Trp Leu Pro Pro Trp Leu Ile Gly Arg Met Leu Gln 
865                 870                 875                 880 


Ala Phe Val Thr Ala Thr Cys Ala His Pro Glu Ser Leu Lys Gly Gln 
                885                 890                 895     


Ser Ile Phe Ser Val Pro Pro Glu Ser Phe Val Cys Asp Asp 
            900                 905                 910 


<210>  119
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  119

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                405                 410                 415     


Ser Gly Gly Ser Ser Gly Gly Cys Pro Met Gly Cys Asp Cys Phe Val 
            420                 425                 430         


Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp 
        435                 440                 445             


Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr 
    450                 455                 460                 


Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val 
465                 470                 475                 480 


Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly 
                485                 490                 495     


Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu 
            500                 505                 510         


Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu 
        515                 520                 525             


Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln 
    530                 535                 540                 


His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln 
545                 550                 555                 560 


Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu 
                565                 570                 575     


Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His 
            580                 585                 590         


Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser 
        595                 600                 605             


Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu 
    610                 615                 620                 


Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser 
625                 630                 635                 640 


Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr 
                645                 650                 655     


His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu 
            660                 665                 670         


Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala 
        675                 680                 685             


His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu 
    690                 695                 700                 


Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu 
705                 710                 715                 720 


Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg 
                725                 730                 735     


Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr 
            740                 745                 750         


Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu 
        755                 760                 765             


Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp 
    770                 775                 780                 


Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln 
785                 790                 795                 800 


Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr 
                805                 810                 815     


Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu 
            820                 825                 830         


Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys 
        835                 840                 845         


<210>  120
<211>  861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  120

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                405                 410                 415     


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            420                 425                 430         


Ser Ser Ser Gly Gly Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu 
        435                 440                 445             


Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro 
    450                 455                 460                 


Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu 
465                 470                 475                 480 


Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe 
                485                 490                 495     


Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu 
            500                 505                 510         


Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu 
        515                 520                 525             


Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu 
    530                 535                 540                 


Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu 
545                 550                 555                 560 


Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu 
                565                 570                 575     


Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu 
            580                 585                 590         


Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu 
        595                 600                 605             


Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu 
    610                 615                 620                 


Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu 
625                 630                 635                 640 


Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu 
                645                 650                 655     


Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu 
            660                 665                 670         


Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu 
        675                 680                 685             


Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr 
    690                 695                 700                 


Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val 
705                 710                 715                 720 


Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu 
                725                 730                 735     


Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu 
            740                 745                 750         


Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu 
        755                 760                 765             


His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu 
    770                 775                 780                 


Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn 
785                 790                 795                 800 


Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp 
                805                 810                 815     


Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg 
            820                 825                 830         


Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly 
        835                 840                 845             


Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys 
    850                 855                 860     


<210>  121
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  121

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Gly Ser Ser Gly Gly Cys Pro Met Gly Cys Asp Cys Phe Val Gln 
            420                 425                 430         


Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile 
        435                 440                 445             


Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr 
    450                 455                 460                 


Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val 
465                 470                 475                 480 


Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly 
                485                 490                 495     


Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn 
            500                 505                 510         


Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr 
        515                 520                 525             


Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His 
    530                 535                 540                 


Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala 
545                 550                 555                 560 


Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn 
                565                 570                 575     


Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro 
            580                 585                 590         


Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly 
        595                 600                 605             


Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe 
    610                 615                 620                 


Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln 
625                 630                 635                 640 


Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His 
                645                 650                 655     


Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser 
            660                 665                 670         


Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His 
        675                 680                 685             


Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr 
    690                 695                 700                 


Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met 
705                 710                 715                 720 


Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp 
                725                 730                 735     


Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala 
            740                 745                 750         


Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser 
        755                 760                 765             


Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr 
    770                 775                 780                 


Asn Tyr Asn Leu Phe Asn Leu Ala Leu Ser His Asn Pro Leu Asp Cys 
785                 790                 795                 800 


Thr Ser Ser Asn Ile His Phe Ile Thr Trp Tyr Lys Glu Asn Leu His 
                805                 810                 815     


Lys Leu Glu Asp Ser Glu Glu Thr Thr Cys Ala Asn Pro Pro Ser Leu 
            820                 825                 830         


Arg Gly Val Lys Leu 
        835         


<210>  122
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  122

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
            420                 425                 430         


Ser Ser Gly Gly Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val 
        435                 440                 445             


Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro 
    450                 455                 460                 


Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu 
465                 470                 475                 480 


Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu 
                485                 490                 495     


Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro 
            500                 505                 510         


Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser 
        515                 520                 525             


Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn 
    530                 535                 540                 


Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala 
545                 550                 555                 560 


Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro 
                565                 570                 575     


Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala 
            580                 585                 590         


Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr 
        595                 600                 605             


Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro 
    610                 615                 620                 


Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp 
625                 630                 635                 640 


Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe 
                645                 650                 655     


Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro 
            660                 665                 670         


Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln 
        675                 680                 685             


Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro 
    690                 695                 700                 


Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala 
705                 710                 715                 720 


Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser 
                725                 730                 735     


Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu 
            740                 745                 750         


Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His 
        755                 760                 765             


Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser 
    770                 775                 780                 


Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr 
785                 790                 795                 800 


Asn Leu Phe Asn Leu Ala Leu Ser His Asn Pro Leu Asp Cys Thr Ser 
                805                 810                 815     


Ser Asn Ile His Phe Ile Thr Trp Tyr Lys Glu Asn Leu His Lys Leu 
            820                 825                 830         


Glu Asp Ser Glu Glu Thr Thr Cys Ala Asn Pro Pro Ser Leu Arg Gly 
        835                 840                 845             


Val Lys Leu 
    850     


<210>  123
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  123

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Ser Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Tyr Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Thr Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  124
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  124

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  125
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  125

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Met Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Ala Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Phe 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  126
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  126

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Ala Tyr Leu Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Leu His Ser Phe Asn Phe Val Leu Met 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Leu 
            260                 265                 270         


Gln Asp Phe Ile Tyr Leu His Thr Asn Cys Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  127
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  127

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Trp Asn Leu His Gly Gly Ala Val Val Val Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Phe Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Leu Thr Ile Glu 
        275                 280                 285             


Tyr Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Ala Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  128
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  128

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Val Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Ile Glu 
        275                 280                 285             


Thr Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  129
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  129

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ile Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  130
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  130

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Leu Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  131
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  131

Ile Thr Trp Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Leu Leu Met Leu Trp Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  132
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  132

Ile Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Leu Leu Met Leu Trp Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
385                 390                 395             


<210>  133
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  133

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Ser Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Tyr Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Thr Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  134
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  134

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  135
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  135

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Met Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Ala Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Phe 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  136
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  136

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Ala Tyr Leu Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Leu His Ser Phe Asn Phe Val Leu Met 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Leu 
            260                 265                 270         


Gln Asp Phe Ile Tyr Leu His Thr Asn Cys Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  137
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  137

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Trp Asn Leu His Gly Gly Ala Val Val Val Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Phe Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Leu Thr Ile Glu 
        275                 280                 285             


Tyr Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Ala Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  138
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  138

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Val Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Ile Glu 
        275                 280                 285             


Thr Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  139
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  139

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ile Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  140
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  140

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Leu Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  141
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  141

Ile Thr Trp Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Leu Leu Met Leu Trp Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  142
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  142

Ile Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Leu Leu Met Leu Trp Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  143
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  143

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser Ser 
            500                 505                 510         


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
        515                 520                 525             


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly Cys 
    530                 535                 540                 


Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr 
545                 550                 555                 560 


Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu 
                565                 570                 575     


Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn 
            580                 585                 590         


Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro 
        595                 600                 605             


Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly 
    610                 615                 620                 


Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser 
625                 630                 635                 640 


Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu 
                645                 650                 655     


Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly 
            660                 665                 670         


Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His 
        675                 680                 685             


Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu 
    690                 695                 700                 


Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn 
705                 710                 715                 720 


Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser 
                725                 730                 735     


Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro 
            740                 745                 750         


Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg 
        755                 760                 765             


Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn 
    770                 775                 780                 


Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala 
785                 790                 795                 800 


Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His 
                805                 810                 815     


Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn 
            820                 825                 830         


Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala 
        835                 840                 845             


Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser 
    850                 855                 860                 


Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys 
865                 870                 875                 880 


Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu 
                885                 890                 895     


Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly 
            900                 905                 910         


Asn Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu 
        915                 920                 925             


Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly 
    930                 935                 940                 


Pro Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln 
945                 950                 955                 960 


Leu Val Cys 
            


<210>  144
<211>  954
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  144

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser Ser 
            500                 505                 510         


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
        515                 520                 525             


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly Cys 
    530                 535                 540                 


Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr 
545                 550                 555                 560 


Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu 
                565                 570                 575     


Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn 
            580                 585                 590         


Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro 
        595                 600                 605             


Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly 
    610                 615                 620                 


Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser 
625                 630                 635                 640 


Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu 
                645                 650                 655     


Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly 
            660                 665                 670         


Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His 
        675                 680                 685             


Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu 
    690                 695                 700                 


Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn 
705                 710                 715                 720 


Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser 
                725                 730                 735     


Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro 
            740                 745                 750         


Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg 
        755                 760                 765             


Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn 
    770                 775                 780                 


Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala 
785                 790                 795                 800 


Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His 
                805                 810                 815     


Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn 
            820                 825                 830         


Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala 
        835                 840                 845             


Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser 
    850                 855                 860                 


Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys 
865                 870                 875                 880 


Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu 
                885                 890                 895     


Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu Ser His 
            900                 905                 910         


Asn Pro Leu Asp Cys Thr Ser Ser Asn Ile His Phe Ile Thr Trp Tyr 
        915                 920                 925             


Lys Glu Asn Leu His Lys Leu Glu Asp Ser Glu Glu Thr Thr Cys Ala 
    930                 935                 940                 


Asn Pro Pro Ser Leu Arg Gly Val Lys Leu 
945                 950                 


<210>  145
<211>  965
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  145

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser Ser 
            500                 505                 510         


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
        515                 520                 525             


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly Cys 
    530                 535                 540                 


Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr 
545                 550                 555                 560 


Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu 
                565                 570                 575     


Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn 
            580                 585                 590         


Leu Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro 
        595                 600                 605             


Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly 
    610                 615                 620                 


Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser 
625                 630                 635                 640 


Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu 
                645                 650                 655     


Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly 
            660                 665                 670         


Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His 
        675                 680                 685             


Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu 
    690                 695                 700                 


Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn 
705                 710                 715                 720 


Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser 
                725                 730                 735     


Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro 
            740                 745                 750         


Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg 
        755                 760                 765             


Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn 
    770                 775                 780                 


Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala 
785                 790                 795                 800 


Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His 
                805                 810                 815     


Asn Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn 
            820                 825                 830         


Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala 
        835                 840                 845             


Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser 
    850                 855                 860                 


Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys 
865                 870                 875                 880 


Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu 
                885                 890                 895     


Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe Glu Leu His Ile Ser Ser 
            900                 905                 910         


Asp Ser Phe Leu Cys Asp Cys Gln Leu Lys Leu Trp Leu Pro Pro Trp 
        915                 920                 925             


Leu Ile Gly Arg Met Leu Gln Ala Phe Val Thr Ala Thr Cys Ala His 
    930                 935                 940                 


Pro Glu Ser Leu Lys Gly Gln Ser Ile Phe Ser Val Pro Pro Glu Ser 
945                 950                 955                 960 


Phe Val Cys Asp Asp 
                965 


<210>  146
<211>  962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  146

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser Gly 
            500                 505                 510         


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
        515                 520                 525             


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly Cys Asp 
    530                 535                 540                 


Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val 
545                 550                 555                 560 


Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr 
                565                 570                 575     


Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu 
            580                 585                 590         


Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp 
        595                 600                 605             


Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser 
    610                 615                 620                 


Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu 
625                 630                 635                 640 


Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly 
                645                 650                 655     


Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn 
            660                 665                 670         


Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu 
        675                 680                 685             


Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu 
    690                 695                 700                 


Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn 
705                 710                 715                 720 


Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu 
                725                 730                 735     


Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln 
            740                 745                 750         


Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn 
        755                 760                 765             


Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu 
    770                 775                 780                 


Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly 
785                 790                 795                 800 


Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn 
                805                 810                 815     


Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu 
            820                 825                 830         


Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly 
        835                 840                 845             


Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn 
    850                 855                 860                 


Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu 
865                 870                 875                 880 


Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly 
                885                 890                 895     


Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn 
            900                 905                 910         


Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln 
        915                 920                 925             


Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro 
    930                 935                 940                 


Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu 
945                 950                 955                 960 


Val Cys 
        


<210>  147
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  147

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser Gly 
            500                 505                 510         


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
        515                 520                 525             


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly Cys Asp 
    530                 535                 540                 


Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val 
545                 550                 555                 560 


Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr 
                565                 570                 575     


Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu 
            580                 585                 590         


Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp 
        595                 600                 605             


Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser 
    610                 615                 620                 


Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu 
625                 630                 635                 640 


Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly 
                645                 650                 655     


Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn 
            660                 665                 670         


Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu 
        675                 680                 685             


Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu 
    690                 695                 700                 


Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn 
705                 710                 715                 720 


Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu 
                725                 730                 735     


Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln 
            740                 745                 750         


Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn 
        755                 760                 765             


Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu 
    770                 775                 780                 


Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly 
785                 790                 795                 800 


Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn 
                805                 810                 815     


Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu 
            820                 825                 830         


Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly 
        835                 840                 845             


Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn 
    850                 855                 860                 


Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu 
865                 870                 875                 880 


Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly 
                885                 890                 895     


Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn 
            900                 905                 910         


Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln 
        915                 920                 925             


Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro 
    930                 935                 940                 


Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu 
945                 950                 955                 960 


Val Cys Leu Ser His Asn Pro Leu Asp Cys Thr Ser Ser Asn Ile His 
                965                 970                 975     


Phe Ile Thr Trp Tyr Lys Glu Asn Leu His Lys Leu Glu Asp Ser Glu 
            980                 985                 990         


Glu Thr Thr Cys Ala Asn Pro Pro  Ser Leu Arg Gly Val  Lys Leu 
        995                 1000                 1005         


<210>  148
<211>  1021
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  148

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser Gly 
            500                 505                 510         


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
        515                 520                 525             


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Cys Pro Met Gly Cys Asp 
    530                 535                 540                 


Cys Phe Val Gln Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val 
545                 550                 555                 560 


Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr 
                565                 570                 575     


Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu 
            580                 585                 590         


Thr Lys Val Val Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp 
        595                 600                 605             


Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser 
    610                 615                 620                 


Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu 
625                 630                 635                 640 


Gly Lys Leu Thr Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly 
                645                 650                 655     


Leu Phe Gln His Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn 
            660                 665                 670         


Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu 
        675                 680                 685             


Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu 
    690                 695                 700                 


Leu Phe His Pro Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn 
705                 710                 715                 720 


Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu 
                725                 730                 735     


Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln 
            740                 745                 750         


Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn 
        755                 760                 765             


Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu 
    770                 775                 780                 


Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly 
785                 790                 795                 800 


Leu Phe Ala His Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn 
                805                 810                 815     


Gln Leu Glu Thr Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu 
            820                 825                 830         


Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly 
        835                 840                 845             


Ile Phe Arg Asp Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn 
    850                 855                 860                 


Asn Leu Thr Ala Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu 
865                 870                 875                 880 


Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly 
                885                 890                 895     


Ile Phe Asp Thr Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn 
            900                 905                 910         


Pro Trp Gln Cys Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln 
        915                 920                 925             


Gln Tyr Thr Asp Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro 
    930                 935                 940                 


Ala Tyr Leu Lys Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu 
945                 950                 955                 960 


Val Cys Glu Leu His Ile Ser Ser Asp Ser Phe Leu Cys Asp Cys Gln 
                965                 970                 975     


Leu Lys Leu Trp Leu Pro Pro Trp Leu Ile Gly Arg Met Leu Gln Ala 
            980                 985                 990         


Phe Val Thr Ala Thr Cys Ala His  Pro Glu Ser Leu Lys  Gly Gln Ser 
        995                 1000                 1005             


Ile Phe  Ser Val Pro Pro Glu  Ser Phe Val Cys Asp  Asp 
    1010                 1015                 1020     


<210>  149
<211>  958
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  149

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser Ser 
            500                 505                 510         


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
        515                 520                 525             


Gly Gly Ser Ser Gly Gly Cys Pro Met Gly Cys Asp Cys Phe Val Gln 
    530                 535                 540                 


Glu Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile 
545                 550                 555                 560 


Pro Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr 
                565                 570                 575     


Leu Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val 
            580                 585                 590         


Phe Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly 
        595                 600                 605             


Leu Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn 
    610                 615                 620                 


Leu Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr 
625                 630                 635                 640 


Leu Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His 
                645                 650                 655     


Leu Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala 
            660                 665                 670         


Leu Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn 
        675                 680                 685             


Leu Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro 
    690                 695                 700                 


Leu Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly 
705                 710                 715                 720 


Leu Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe 
                725                 730                 735     


Leu Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln 
            740                 745                 750         


Leu Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His 
        755                 760                 765             


Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser 
    770                 775                 780                 


Leu Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His 
785                 790                 795                 800 


Thr Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr 
                805                 810                 815     


Val Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met 
            820                 825                 830         


Leu Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp 
        835                 840                 845             


Leu Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala 
    850                 855                 860                 


Leu His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser 
865                 870                 875                 880 


Leu Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr 
                885                 890                 895     


Asn Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys 
            900                 905                 910         


Asp Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp 
        915                 920                 925             


Arg Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys 
    930                 935                 940                 


Gly Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys 
945                 950                 955             


<210>  150
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  150

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Gly Gly Ser Ser 
            500                 505                 510         


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
        515                 520                 525             


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
    530                 535                 540                 


Ser Ser Gly Gly Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val 
545                 550                 555                 560 


Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro 
                565                 570                 575     


Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu 
            580                 585                 590         


Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu 
        595                 600                 605             


Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro 
    610                 615                 620                 


Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser 
625                 630                 635                 640 


Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn 
                645                 650                 655     


Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala 
            660                 665                 670         


Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro 
        675                 680                 685             


Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala 
    690                 695                 700                 


Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr 
705                 710                 715                 720 


Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro 
                725                 730                 735     


Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp 
            740                 745                 750         


Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe 
        755                 760                 765             


Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro 
    770                 775                 780                 


Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln 
785                 790                 795                 800 


Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro 
                805                 810                 815     


Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala 
            820                 825                 830         


Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser 
        835                 840                 845             


Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu 
    850                 855                 860                 


Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His 
865                 870                 875                 880 


Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser 
                885                 890                 895     


Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr 
            900                 905                 910         


Asn Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp Cys 
        915                 920                 925             


His Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg Leu 
    930                 935                 940                 


Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly Gln 
945                 950                 955                 960 


Val Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys 
                965                 970         


<210>  151
<211>  948
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  151

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser Gly 
            500                 505                 510         


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
        515                 520                 525             


Gly Ser Ser Gly Gly Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu 
    530                 535                 540                 


Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro 
545                 550                 555                 560 


Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu 
                565                 570                 575     


Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe 
            580                 585                 590         


Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu 
        595                 600                 605             


Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu 
    610                 615                 620                 


Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu 
625                 630                 635                 640 


Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu 
                645                 650                 655     


Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu 
            660                 665                 670         


Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu 
        675                 680                 685             


Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu 
    690                 695                 700                 


Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu 
705                 710                 715                 720 


Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu 
                725                 730                 735     


Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu 
            740                 745                 750         


Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu 
        755                 760                 765             


Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu 
    770                 775                 780                 


Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr 
785                 790                 795                 800 


Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val 
                805                 810                 815     


Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu 
            820                 825                 830         


Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu 
        835                 840                 845             


Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu 
    850                 855                 860                 


His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu 
865                 870                 875                 880 


Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn 
                885                 890                 895     


Tyr Asn Leu Phe Asn Leu Ala Leu Ser His Asn Pro Leu Asp Cys Thr 
            900                 905                 910         


Ser Ser Asn Ile His Phe Ile Thr Trp Tyr Lys Glu Asn Leu His Lys 
        915                 920                 925             


Leu Glu Asp Ser Glu Glu Thr Thr Cys Ala Asn Pro Pro Ser Leu Arg 
    930                 935                 940                 


Gly Val Lys Leu 
945             


<210>  152
<211>  962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  152

Gly His His His His His His His His His His Gly Ser Leu Gln Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Val 
            100                 105                 110         


Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr Lys 
        115                 120                 125             


Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His Pro 
145                 150                 155                 160 


Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn Met 
                165                 170                 175     


His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser Glu 
            180                 185                 190         


Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln Leu 
        195                 200                 205             


Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp Gly 
    210                 215                 220                 


Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu Val 
225                 230                 235                 240 


Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro Asp 
                245                 250                 255     


Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn His 
            260                 265                 270         


His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu Thr 
        275                 280                 285             


Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser Ala 
    290                 295                 300                 


Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser 
305                 310                 315                 320 


Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro Thr 
                325                 330                 335     


Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala 
            340                 345                 350         


His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp 
        355                 360                 365             


Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln 
    370                 375                 380                 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu 
385                 390                 395                 400 


Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu 
                405                 410                 415     


Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln Gly 
            420                 425                 430         


Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn Ala 
        435                 440                 445             


Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp His 
    450                 455                 460                 


Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala 
465                 470                 475                 480 


Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly Pro 
                485                 490                 495     


Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Gly Gly Ser Ser Gly 
            500                 505                 510         


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
        515                 520                 525             


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Ser 
    530                 535                 540                 


Ser Gly Gly Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe 
545                 550                 555                 560 


Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr 
                565                 570                 575     


Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr 
            580                 585                 590         


Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asn 
        595                 600                 605             


Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg 
    610                 615                 620                 


Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr 
625                 630                 635                 640 


Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe 
                645                 650                 655     


Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala 
            660                 665                 670         


Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg 
        675                 680                 685             


Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln 
    690                 695                 700                 


Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser 
705                 710                 715                 720 


Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln 
                725                 730                 735     


Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser 
            740                 745                 750         


Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys 
        755                 760                 765             


Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu 
    770                 775                 780                 


Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp 
785                 790                 795                 800 


Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys 
                805                 810                 815     


Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala Glu 
            820                 825                 830         


Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr 
        835                 840                 845             


Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu 
    850                 855                 860                 


Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro 
865                 870                 875                 880 


Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys 
                885                 890                 895     


Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr Asn 
            900                 905                 910         


Leu Phe Asn Leu Ala Leu Ser His Asn Pro Leu Asp Cys Thr Ser Ser 
        915                 920                 925             


Asn Ile His Phe Ile Thr Trp Tyr Lys Glu Asn Leu His Lys Leu Glu 
    930                 935                 940                 


Asp Ser Glu Glu Thr Thr Cys Ala Asn Pro Pro Ser Leu Arg Gly Val 
945                 950                 955                 960 


Lys Leu 
        


<210>  153
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  153

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  154
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  154

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  155
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  155

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  156
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  156

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  157
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  157

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  158
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  158

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  159
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  159

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ser Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  160
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  160

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Arg Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  161
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  161

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Thr Tyr Asn Gln Asp Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  162
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  162

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Tyr Arg Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  163
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  163

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Asp Thr Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  164
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  164

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp His Asn Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  165
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  165

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Arg Glu Tyr Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  166
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  166

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp His Asn Gln Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  167
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  167

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Ile Pro Asp Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  168
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  168

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Trp Arg Tyr Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  169
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  169

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Tyr Arg Tyr Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  170
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  170

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Gln Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  171
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  171

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Thr Tyr Asn Gln Asp Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Pro Gln Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  172
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  172

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Thr Tyr Asn Gln Asp Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Pro Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  173
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  173

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Ile Trp Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  174
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  174

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Leu Phe Pro Pro Pro Gln Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  175
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  175

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Ile Phe Leu Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  176
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  176

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Ile Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  177
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  177

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asn Ala Phe Thr Pro Glu Ser Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  178
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  178

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asn Ala Phe Pro Pro Glu Ser Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  179
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  179

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Ala Trp Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  180
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  180

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Ala Trp Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  181
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  181

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Val Phe Leu Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  182
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  182

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Val Phe Pro Pro Glu Asp Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  183
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  183

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Asn Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  184
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  184

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Leu Trp Pro Pro Glu Leu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  185
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  185

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asn Leu Trp Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  186
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  186

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Trp Arg Ala Gly Asp Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Ile Gln Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  187
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  187

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Tyr Arg Pro Gly Glu Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Val Met Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  188
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  188

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Thr Tyr Asn Gln Asp Gly Trp Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Leu Phe Pro Pro Pro Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  189
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  189

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Tyr Arg Pro Gly Asp Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Ile Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  190
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  190

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Ser Thr Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asn Ala Phe Pro Pro Glu Ser Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  191
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  191

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gln Trp Asp Lys Pro Gly Ile Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Ala Ile Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  192
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  192

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Trp Asp Lys Pro Gly Ile Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Ala Trp Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  193
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  193

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Trp Arg His Pro Gly Ser Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Val Phe Pro Pro Glu Trp Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  194
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  194

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Trp Arg Tyr Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Val Phe Pro Pro Glu Asp Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  195
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  195

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Gln Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Leu Trp Pro Pro Glu Leu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  196
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  196

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Asp Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Leu Trp Pro Pro Asp Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  197
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  197

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys His Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  198
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  198

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Leu Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  199
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  199

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Ala Asp Ile Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  200
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  200

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Ala Asp Ser Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  201
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  201

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Glu Arg Asp Ile Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  202
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  202

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Arg Asp Thr Ser Gln Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  203
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  203

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asp Asp Ser Gln Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  204
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  204

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  205
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  205

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Lys Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Asn Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  206
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  206

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val His Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  207
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  207

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asp Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  208
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  208

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Asp Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  209
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  209

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Asp Ala Val Tyr Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  210
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  210

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  211
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  211

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  212
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  212

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  213
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  213

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  214
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  214

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  215
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  215

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  216
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  216

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ser Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  217
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  217

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Arg Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  218
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  218

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Thr Tyr Asn Gln Asp Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  219
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  219

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Tyr Arg Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  220
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  220

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Asp Thr Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  221
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  221

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp His Asn Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  222
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  222

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Arg Glu Tyr Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  223
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  223

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp His Asn Gln Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  224
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  224

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Ile Pro Asp Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  225
<211>  924
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  225

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Arg His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asp Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


Glu Asn Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
                325                 330                 335     


Ser Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
            340                 345                 350         


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
        355                 360                 365             


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
    370                 375                 380                 


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
385                 390                 395                 400 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
                405                 410                 415     


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
            420                 425                 430         


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
        435                 440                 445             


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
    450                 455                 460                 


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
465                 470                 475                 480 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
                485                 490                 495     


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
            500                 505                 510         


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
        515                 520                 525             


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
    530                 535                 540                 


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
545                 550                 555                 560 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
                565                 570                 575     


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
            580                 585                 590         


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
        595                 600                 605             


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
    610                 615                 620                 


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
625                 630                 635                 640 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
                645                 650                 655     


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
            660                 665                 670         


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
        675                 680                 685             


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
    690                 695                 700                 


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
705                 710                 715                 720 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
                725                 730                 735     


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
            740                 745                 750         


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
        755                 760                 765             


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
    770                 775                 780                 


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
785                 790                 795                 800 


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
                805                 810                 815     


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
            820                 825                 830         


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
        835                 840                 845             


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
    850                 855                 860                 


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
865                 870                 875                 880 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
                885                 890                 895     


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
            900                 905                 910         


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
        915                 920                 


<210>  226
<211>  924
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  226

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Ser His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Arg Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


Glu Asn Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
                325                 330                 335     


Ser Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
            340                 345                 350         


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
        355                 360                 365             


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
    370                 375                 380                 


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
385                 390                 395                 400 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
                405                 410                 415     


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
            420                 425                 430         


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
        435                 440                 445             


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
    450                 455                 460                 


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
465                 470                 475                 480 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
                485                 490                 495     


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
            500                 505                 510         


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
        515                 520                 525             


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
    530                 535                 540                 


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
545                 550                 555                 560 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
                565                 570                 575     


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
            580                 585                 590         


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
        595                 600                 605             


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
    610                 615                 620                 


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
625                 630                 635                 640 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
                645                 650                 655     


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
            660                 665                 670         


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
        675                 680                 685             


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
    690                 695                 700                 


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
705                 710                 715                 720 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
                725                 730                 735     


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
            740                 745                 750         


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
        755                 760                 765             


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
    770                 775                 780                 


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
785                 790                 795                 800 


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
                805                 810                 815     


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
            820                 825                 830         


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
        835                 840                 845             


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
    850                 855                 860                 


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
865                 870                 875                 880 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
                885                 890                 895     


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
            900                 905                 910         


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
        915                 920                 


<210>  227
<211>  924
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  227

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Lys His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


Glu Asn Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
                325                 330                 335     


Ser Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
            340                 345                 350         


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
        355                 360                 365             


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
    370                 375                 380                 


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
385                 390                 395                 400 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
                405                 410                 415     


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
            420                 425                 430         


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
        435                 440                 445             


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
    450                 455                 460                 


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
465                 470                 475                 480 


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
                485                 490                 495     


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
            500                 505                 510         


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
        515                 520                 525             


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
    530                 535                 540                 


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
545                 550                 555                 560 


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
                565                 570                 575     


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
            580                 585                 590         


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
        595                 600                 605             


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
    610                 615                 620                 


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
625                 630                 635                 640 


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
                645                 650                 655     


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
            660                 665                 670         


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
        675                 680                 685             


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
    690                 695                 700                 


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
705                 710                 715                 720 


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
                725                 730                 735     


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
            740                 745                 750         


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
        755                 760                 765             


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
    770                 775                 780                 


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
785                 790                 795                 800 


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
                805                 810                 815     


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
            820                 825                 830         


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
        835                 840                 845             


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
    850                 855                 860                 


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
865                 870                 875                 880 


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
                885                 890                 895     


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
            900                 905                 910         


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
        915                 920                 


<210>  228
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  228

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Trp Arg Tyr Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  229
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  229

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Tyr Arg Tyr Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  230
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  230

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Gln Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  231
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  231

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  232
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  232

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asp Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  233
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  233

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Pro Asp Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  234
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  234

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Ala Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  235
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  235

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Arg Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  236
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  236

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  237
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  237

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Pro Asp Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  238
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  238

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  239
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  239

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Gly Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  240
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  240

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Ser Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  241
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  241

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Gly Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  242
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  242

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Asn Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  243
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  243

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Gly Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  244
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  244

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Gln Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  245
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  245

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  246
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  246

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  247
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  247

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  248
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  248

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  249
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  249

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  250
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  250

Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Ala Ala Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Ala Ala Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu His Ala Phe Asn His Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Ala Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Val Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Ala Ala Leu Ala Ala Ala Gln Thr Asn Ala 
        355                 360                 365             


Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln Gly 
    370                 375                 380                 


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
385                 390                 395                 400 


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
                405                 410                 415     


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
            420                 425                 430         


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
        435                 440                 445             


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
    450                 455                 460                 


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
465                 470                 475                 480 


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
                485                 490                 495     


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
            500                 505                 510         


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
        515                 520                 525             


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
    530                 535                 540                 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
545                 550                 555                 560 


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
                565                 570                 575     


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
            580                 585                 590         


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
        595                 600                 605             


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
    610                 615                 620                 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
625                 630                 635                 640 


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
                645                 650                 655     


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
            660                 665                 670         


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
        675                 680                 685             


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
    690                 695                 700                 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
                725                 730                 735     


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
            740                 745                 750         


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
        755                 760                 765             


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
    770                 775                 780         


<210>  251
<211>  1386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  251

Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Ala Ala Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Ala Ala Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu His Ala Phe Asn His Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Ala Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Val Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Ala Ala Leu Ala Ala Ala Gln Thr Asn Ala 
        355                 360                 365             


Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln Gly 
    370                 375                 380                 


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
385                 390                 395                 400 


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
                405                 410                 415     


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
            420                 425                 430         


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
        435                 440                 445             


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
    450                 455                 460                 


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
465                 470                 475                 480 


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
                485                 490                 495     


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
            500                 505                 510         


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
        515                 520                 525             


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
    530                 535                 540                 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
545                 550                 555                 560 


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
                565                 570                 575     


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
            580                 585                 590         


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
        595                 600                 605             


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
    610                 615                 620                 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
625                 630                 635                 640 


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
                645                 650                 655     


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
            660                 665                 670         


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
        675                 680                 685             


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
    690                 695                 700                 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
                725                 730                 735     


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
            740                 745                 750         


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
        755                 760                 765             


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
    770                 775                 780                 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
785                 790                 795                 800 


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
                805                 810                 815     


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
            820                 825                 830         


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
        835                 840                 845             


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
    850                 855                 860                 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
865                 870                 875                 880 


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
                885                 890                 895     


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
            900                 905                 910         


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
        915                 920                 925             


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
    930                 935                 940                 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
945                 950                 955                 960 


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
                965                 970                 975     


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
            980                 985                 990         


Ser Ser Ala Lys Gln Arg Leu Lys  Cys Ala Ser Leu Gln  Lys Phe Gly 
        995                 1000                 1005             


Glu Arg  Ala Phe Lys Ala Trp  Ala Val Ala Arg Leu  Ser Gln Arg 
    1010                 1015                 1020             


Phe Pro  Lys Ala Glu Phe Ala  Glu Val Ser Lys Leu  Val Thr Asp 
    1025                 1030                 1035             


Leu Thr  Lys Val His Thr Glu  Cys Cys His Gly Asp  Leu Leu Glu 
    1040                 1045                 1050             


Cys Ala  Asp Asp Arg Ala Asp  Leu Ala Lys Tyr Ile  Cys Glu Asn 
    1055                 1060                 1065             


Gln Asp  Ser Ile Ser Ser Lys  Leu Lys Glu Cys Cys  Glu Lys Pro 
    1070                 1075                 1080             


Leu Leu  Glu Lys Ser His Cys  Ile Ala Glu Val Glu  Asn Asp Glu 
    1085                 1090                 1095             


Met Pro  Ala Asp Leu Pro Ser  Leu Ala Ala Asp Phe  Val Glu Ser 
    1100                 1105                 1110             


Lys Asp  Val Cys Lys Asn Tyr  Ala Glu Ala Lys Asp  Val Phe Leu 
    1115                 1120                 1125             


Gly Met  Phe Leu Tyr Glu Tyr  Ala Arg Arg His Pro  Asp Tyr Ser 
    1130                 1135                 1140             


Val Val  Leu Leu Leu Arg Leu  Ala Lys Thr Tyr Glu  Thr Thr Leu 
    1145                 1150                 1155             


Glu Lys  Cys Cys Ala Ala Ala  Asp Pro His Glu Cys  Tyr Ala Lys 
    1160                 1165                 1170             


Val Phe  Asp Glu Phe Lys Pro  Leu Val Glu Glu Pro  Gln Asn Leu 
    1175                 1180                 1185             


Ile Lys  Gln Asn Cys Glu Leu  Phe Glu Gln Leu Gly  Glu Tyr Lys 
    1190                 1195                 1200             


Phe Gln  Asn Ala Leu Leu Val  Arg Tyr Thr Lys Lys  Val Pro Gln 
    1205                 1210                 1215             


Val Ser  Thr Pro Thr Leu Val  Glu Val Ser Arg Asn  Leu Gly Lys 
    1220                 1225                 1230             


Val Gly  Ser Lys Cys Cys Lys  His Pro Glu Ala Lys  Arg Met Pro 
    1235                 1240                 1245             


Cys Ala  Glu Asp Tyr Leu Ser  Val Val Leu Asn Gln  Leu Cys Val 
    1250                 1255                 1260             


Leu His  Glu Lys Thr Pro Val  Ser Asp Arg Val Thr  Lys Cys Cys 
    1265                 1270                 1275             


Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys Phe Ser  Ala Leu Glu 
    1280                 1285                 1290             


Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe Asn Ala  Glu Thr Phe 
    1295                 1300                 1305             


Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser Glu Lys  Glu Arg Gln 
    1310                 1315                 1320             


Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu Val Lys  His Lys Pro 
    1325                 1330                 1335             


Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val Met Asp  Asp Phe Ala 
    1340                 1345                 1350             


Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp Asp Lys  Glu Thr Cys 
    1355                 1360                 1365             


Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala Ala Ser  Gln Ala Ala 
    1370                 1375                 1380             


Leu Gly  Leu 
    1385     


<210>  252
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  252

Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Ala Ala Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Ala Ala Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu His Ala Phe Asn His Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Ala Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Val Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Ala Ala Leu Ala Ala Ala Gln Thr Asn Ala 
        355                 360                 365             


Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln Gly 
    370                 375                 380                 


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
385                 390                 395                 400 


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
                405                 410                 415     


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
            420                 425                 430         


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
        435                 440                 445             


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
    450                 455                 460                 


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
465                 470                 475                 480 


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
                485                 490                 495     


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
            500                 505                 510         


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
        515                 520                 525             


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
    530                 535                 540                 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
545                 550                 555                 560 


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
                565                 570                 575     


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
            580                 585                 590         


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
        595                 600                 605             


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
    610                 615                 620                 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
625                 630                 635                 640 


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
                645                 650                 655     


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
            660                 665                 670         


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
        675                 680                 685             


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
    690                 695                 700                 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
                725                 730                 735     


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
            740                 745                 750         


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
        755                 760                 765             


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
    770                 775                 780                 


Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly Val Arg 
785                 790                 795                 800 


Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln 
                805                 810                 815     


Leu Gln Arg Gly Pro Ala 
            820         


<210>  253
<211>  1426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  253

Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Ala Ala Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Ala Ala Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu His Ala Phe Asn His Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Ala Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Val Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Ala Ala Leu Ala Ala Ala Gln Thr Asn Ala 
        355                 360                 365             


Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln Gly 
    370                 375                 380                 


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
385                 390                 395                 400 


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
                405                 410                 415     


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
            420                 425                 430         


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
        435                 440                 445             


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
    450                 455                 460                 


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
465                 470                 475                 480 


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
                485                 490                 495     


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
            500                 505                 510         


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
        515                 520                 525             


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
    530                 535                 540                 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
545                 550                 555                 560 


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
                565                 570                 575     


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
            580                 585                 590         


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
        595                 600                 605             


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
    610                 615                 620                 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
625                 630                 635                 640 


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
                645                 650                 655     


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
            660                 665                 670         


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
        675                 680                 685             


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
    690                 695                 700                 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
                725                 730                 735     


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
            740                 745                 750         


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
        755                 760                 765             


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
    770                 775                 780                 


Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly Val Arg 
785                 790                 795                 800 


Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln 
                805                 810                 815     


Leu Gln Arg Gly Pro Ala Glu Asn Leu Tyr Phe Gln Gly Gly Ser Ser 
            820                 825                 830         


Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val 
        835                 840                 845             


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
    850                 855                 860                 


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
865                 870                 875                 880 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
                885                 890                 895     


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            900                 905                 910         


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
        915                 920                 925             


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    930                 935                 940                 


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
945                 950                 955                 960 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
                965                 970                 975     


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            980                 985                 990         


Pro Glu Leu Leu Phe Phe Ala Lys  Arg Tyr Lys Ala Ala  Phe Thr Glu 
        995                 1000                 1005             


Cys Cys  Gln Ala Ala Asp Lys  Ala Ala Cys Leu Leu  Pro Lys Leu 
    1010                 1015                 1020             


Asp Glu  Leu Arg Asp Glu Gly  Lys Ala Ser Ser Ala  Lys Gln Arg 
    1025                 1030                 1035             


Leu Lys  Cys Ala Ser Leu Gln  Lys Phe Gly Glu Arg  Ala Phe Lys 
    1040                 1045                 1050             


Ala Trp  Ala Val Ala Arg Leu  Ser Gln Arg Phe Pro  Lys Ala Glu 
    1055                 1060                 1065             


Phe Ala  Glu Val Ser Lys Leu  Val Thr Asp Leu Thr  Lys Val His 
    1070                 1075                 1080             


Thr Glu  Cys Cys His Gly Asp  Leu Leu Glu Cys Ala  Asp Asp Arg 
    1085                 1090                 1095             


Ala Asp  Leu Ala Lys Tyr Ile  Cys Glu Asn Gln Asp  Ser Ile Ser 
    1100                 1105                 1110             


Ser Lys  Leu Lys Glu Cys Cys  Glu Lys Pro Leu Leu  Glu Lys Ser 
    1115                 1120                 1125             


His Cys  Ile Ala Glu Val Glu  Asn Asp Glu Met Pro  Ala Asp Leu 
    1130                 1135                 1140             


Pro Ser  Leu Ala Ala Asp Phe  Val Glu Ser Lys Asp  Val Cys Lys 
    1145                 1150                 1155             


Asn Tyr  Ala Glu Ala Lys Asp  Val Phe Leu Gly Met  Phe Leu Tyr 
    1160                 1165                 1170             


Glu Tyr  Ala Arg Arg His Pro  Asp Tyr Ser Val Val  Leu Leu Leu 
    1175                 1180                 1185             


Arg Leu  Ala Lys Thr Tyr Glu  Thr Thr Leu Glu Lys  Cys Cys Ala 
    1190                 1195                 1200             


Ala Ala  Asp Pro His Glu Cys  Tyr Ala Lys Val Phe  Asp Glu Phe 
    1205                 1210                 1215             


Lys Pro  Leu Val Glu Glu Pro  Gln Asn Leu Ile Lys  Gln Asn Cys 
    1220                 1225                 1230             


Glu Leu  Phe Glu Gln Leu Gly  Glu Tyr Lys Phe Gln  Asn Ala Leu 
    1235                 1240                 1245             


Leu Val  Arg Tyr Thr Lys Lys  Val Pro Gln Val Ser  Thr Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Val Ser Arg Asn  Leu Gly Lys Val Gly  Ser Lys Cys 
    1265                 1270                 1275             


Cys Lys  His Pro Glu Ala Lys  Arg Met Pro Cys Ala  Glu Asp Tyr 
    1280                 1285                 1290             


Leu Ser  Val Val Leu Asn Gln  Leu Cys Val Leu His  Glu Lys Thr 
    1295                 1300                 1305             


Pro Val  Ser Asp Arg Val Thr  Lys Cys Cys Thr Glu  Ser Leu Val 
    1310                 1315                 1320             


Asn Arg  Arg Pro Cys Phe Ser  Ala Leu Glu Val Asp  Glu Thr Tyr 
    1325                 1330                 1335             


Val Pro  Lys Glu Phe Asn Ala  Glu Thr Phe Thr Phe  His Ala Asp 
    1340                 1345                 1350             


Ile Cys  Thr Leu Ser Glu Lys  Glu Arg Gln Ile Lys  Lys Gln Thr 
    1355                 1360                 1365             


Ala Leu  Val Glu Leu Val Lys  His Lys Pro Lys Ala  Thr Lys Glu 
    1370                 1375                 1380             


Gln Leu  Lys Ala Val Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys 
    1385                 1390                 1395             


Cys Cys  Lys Ala Asp Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly 
    1400                 1405                 1410             


Lys Lys  Leu Val Ala Ala Ser  Gln Ala Ala Leu Gly  Leu 
    1415                 1420                 1425     


<210>  254
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  254

Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Ala Ala Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Ala Ala Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu His Ala Phe Asn His Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Ala Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Val Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Ala Ala Leu Ala Ala Ala Gln Thr Asn Ala 
        355                 360                 365             


Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln Gly 
    370                 375                 380                 


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
385                 390                 395                 400 


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
                405                 410                 415     


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
            420                 425                 430         


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
        435                 440                 445             


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
    450                 455                 460                 


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
465                 470                 475                 480 


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
                485                 490                 495     


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
            500                 505                 510         


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
        515                 520                 525             


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
    530                 535                 540                 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
545                 550                 555                 560 


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
                565                 570                 575     


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
            580                 585                 590         


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
        595                 600                 605             


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
    610                 615                 620                 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
625                 630                 635                 640 


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
                645                 650                 655     


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
            660                 665                 670         


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
        675                 680                 685             


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
    690                 695                 700                 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
                725                 730                 735     


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
            740                 745                 750         


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
        755                 760                 765             


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
    770                 775                 780                 


Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly Val Arg 
785                 790                 795                 800 


Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln 
                805                 810                 815     


Leu Gln Arg Gly Pro Ala 
            820         


<210>  255
<211>  1426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  255

Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly 
1               5                   10                  15      


Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly 
            20                  25                  30          


Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro 
        35                  40                  45              


Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His 
    50                  55                  60                  


Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr 
65                  70                  75                  80  


Pro Ala Ala Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala 
                85                  90                  95      


Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala 
            100                 105                 110         


Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr 
        115                 120                 125             


Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys 
    130                 135                 140                 


Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu 
145                 150                 155                 160 


Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Ala Ala Gly Lys Tyr 
                165                 170                 175     


Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr 
        195                 200                 205             


Asp Tyr Ser Ile Ala Glu His Ala Phe Asn His Gly Glu Thr Ala Met 
    210                 215                 220                 


Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Ala Val 
225                 230                 235                 240 


Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys 
                245                 250                 255     


Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn 
            260                 265                 270         


Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu 
        275                 280                 285             


Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu 
    290                 295                 300                 


Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Val Ala Ala Thr 
305                 310                 315                 320 


Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met 
                325                 330                 335     


Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser 
            340                 345                 350         


Gly Arg Gln Thr Val Asp Ala Ala Leu Ala Ala Ala Gln Thr Asn Ala 
        355                 360                 365             


Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln Gly 
    370                 375                 380                 


Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
385                 390                 395                 400 


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
                405                 410                 415     


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
            420                 425                 430         


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
        435                 440                 445             


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
    450                 455                 460                 


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
465                 470                 475                 480 


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
                485                 490                 495     


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
            500                 505                 510         


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
        515                 520                 525             


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
    530                 535                 540                 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
545                 550                 555                 560 


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
                565                 570                 575     


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
            580                 585                 590         


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
        595                 600                 605             


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
    610                 615                 620                 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
625                 630                 635                 640 


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
                645                 650                 655     


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
            660                 665                 670         


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
        675                 680                 685             


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
    690                 695                 700                 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
705                 710                 715                 720 


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
                725                 730                 735     


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
            740                 745                 750         


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
        755                 760                 765             


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
    770                 775                 780                 


Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly Val Arg 
785                 790                 795                 800 


Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln 
                805                 810                 815     


Leu Gln Arg Gly Pro Ala Glu Asn Leu Tyr Phe Gln Gly Gly Ser Ser 
            820                 825                 830         


Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val 
        835                 840                 845             


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
    850                 855                 860                 


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
865                 870                 875                 880 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
                885                 890                 895     


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            900                 905                 910         


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
        915                 920                 925             


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    930                 935                 940                 


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
945                 950                 955                 960 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
                965                 970                 975     


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            980                 985                 990         


Pro Glu Leu Leu Phe Phe Ala Lys  Arg Tyr Lys Ala Ala  Phe Thr Glu 
        995                 1000                 1005             


Cys Cys  Gln Ala Ala Asp Lys  Ala Ala Cys Leu Leu  Pro Lys Leu 
    1010                 1015                 1020             


Asp Glu  Leu Arg Asp Glu Gly  Lys Ala Ser Ser Ala  Lys Gln Arg 
    1025                 1030                 1035             


Leu Lys  Cys Ala Ser Leu Gln  Lys Phe Gly Glu Arg  Ala Phe Lys 
    1040                 1045                 1050             


Ala Trp  Ala Val Ala Arg Leu  Ser Gln Arg Phe Pro  Lys Ala Glu 
    1055                 1060                 1065             


Phe Ala  Glu Val Ser Lys Leu  Val Thr Asp Leu Thr  Lys Val His 
    1070                 1075                 1080             


Thr Glu  Cys Cys His Gly Asp  Leu Leu Glu Cys Ala  Asp Asp Arg 
    1085                 1090                 1095             


Ala Asp  Leu Ala Lys Tyr Ile  Cys Glu Asn Gln Asp  Ser Ile Ser 
    1100                 1105                 1110             


Ser Lys  Leu Lys Glu Cys Cys  Glu Lys Pro Leu Leu  Glu Lys Ser 
    1115                 1120                 1125             


His Cys  Ile Ala Glu Val Glu  Asn Asp Glu Met Pro  Ala Asp Leu 
    1130                 1135                 1140             


Pro Ser  Leu Ala Ala Asp Phe  Val Glu Ser Lys Asp  Val Cys Lys 
    1145                 1150                 1155             


Asn Tyr  Ala Glu Ala Lys Asp  Val Phe Leu Gly Met  Phe Leu Tyr 
    1160                 1165                 1170             


Glu Tyr  Ala Arg Arg His Pro  Asp Tyr Ser Val Val  Leu Leu Leu 
    1175                 1180                 1185             


Arg Leu  Ala Lys Thr Tyr Glu  Thr Thr Leu Glu Lys  Cys Cys Ala 
    1190                 1195                 1200             


Ala Ala  Asp Pro His Glu Cys  Tyr Ala Lys Val Phe  Asp Glu Phe 
    1205                 1210                 1215             


Lys Pro  Leu Val Glu Glu Pro  Gln Asn Leu Ile Lys  Gln Asn Cys 
    1220                 1225                 1230             


Glu Leu  Phe Glu Gln Leu Gly  Glu Tyr Lys Phe Gln  Asn Ala Leu 
    1235                 1240                 1245             


Leu Val  Arg Tyr Thr Lys Lys  Val Pro Gln Val Ser  Thr Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Val Ser Arg Asn  Leu Gly Lys Val Gly  Ser Lys Cys 
    1265                 1270                 1275             


Cys Lys  His Pro Glu Ala Lys  Arg Met Pro Cys Ala  Glu Asp Tyr 
    1280                 1285                 1290             


Leu Ser  Val Val Leu Asn Gln  Leu Cys Val Leu His  Glu Lys Thr 
    1295                 1300                 1305             


Pro Val  Ser Asp Arg Val Thr  Lys Cys Cys Thr Glu  Ser Leu Val 
    1310                 1315                 1320             


Asn Arg  Arg Pro Cys Phe Ser  Ala Leu Glu Val Asp  Glu Thr Tyr 
    1325                 1330                 1335             


Val Pro  Lys Glu Phe Asn Ala  Glu Thr Phe Thr Phe  His Ala Asp 
    1340                 1345                 1350             


Ile Cys  Thr Leu Ser Glu Lys  Glu Arg Gln Ile Lys  Lys Gln Thr 
    1355                 1360                 1365             


Ala Leu  Val Glu Leu Val Lys  His Lys Pro Lys Ala  Thr Lys Glu 
    1370                 1375                 1380             


Gln Leu  Lys Ala Val Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys 
    1385                 1390                 1395             


Cys Cys  Lys Ala Asp Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly 
    1400                 1405                 1410             


Lys Lys  Leu Val Ala Ala Ser  Gln Ala Ala Leu Gly  Leu 
    1415                 1420                 1425     


<210>  256
<211>  1243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  256

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ala Ala Ala Gln Thr Asn 
    210                 215                 220                 


Ala Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu 
                245                 250                 255     


Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile 
            260                 265                 270         


Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp 
        275                 280                 285             


His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly 
    290                 295                 300                 


Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu 
305                 310                 315                 320 


Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val 
                325                 330                 335     


Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro 
            340                 345                 350         


Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr 
        355                 360                 365             


Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe 
    370                 375                 380                 


Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro 
385                 390                 395                 400 


Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro 
                405                 410                 415     


Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu 
            420                 425                 430         


Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp 
        435                 440                 445             


Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr 
    450                 455                 460                 


Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser 
465                 470                 475                 480 


Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe 
                485                 490                 495     


Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly 
            500                 505                 510         


Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu 
        515                 520                 525             


Gln Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu 
    530                 535                 540                 


Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His 
545                 550                 555                 560 


Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala 
                565                 570                 575     


Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly 
            580                 585                 590         


Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val 
        595                 600                 605             


Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val 
    610                 615                 620                 


Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu 
625                 630                 635                 640 


Asn Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                645                 650                 655     


Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu 
            660                 665                 670         


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
        675                 680                 685             


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
    690                 695                 700                 


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
705                 710                 715                 720 


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
                725                 730                 735     


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
            740                 745                 750         


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
        755                 760                 765             


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
    770                 775                 780                 


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
785                 790                 795                 800 


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
                805                 810                 815     


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
            820                 825                 830         


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
        835                 840                 845             


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
    850                 855                 860                 


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
865                 870                 875                 880 


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
                885                 890                 895     


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
            900                 905                 910         


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
        915                 920                 925             


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
    930                 935                 940                 


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
945                 950                 955                 960 


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
                965                 970                 975     


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
            980                 985                 990         


Ala Arg Arg His Pro Asp Tyr Ser  Val Val Leu Leu Leu  Arg Leu Ala 
        995                 1000                 1005             


Lys Thr  Tyr Glu Thr Thr Leu  Glu Lys Cys Cys Ala  Ala Ala Asp 
    1010                 1015                 1020             


Pro His  Glu Cys Tyr Ala Lys  Val Phe Asp Glu Phe  Lys Pro Leu 
    1025                 1030                 1035             


Val Glu  Glu Pro Gln Asn Leu  Ile Lys Gln Asn Cys  Glu Leu Phe 
    1040                 1045                 1050             


Glu Gln  Leu Gly Glu Tyr Lys  Phe Gln Asn Ala Leu  Leu Val Arg 
    1055                 1060                 1065             


Tyr Thr  Lys Lys Val Pro Gln  Val Ser Thr Pro Thr  Leu Val Glu 
    1070                 1075                 1080             


Val Ser  Arg Asn Leu Gly Lys  Val Gly Ser Lys Cys  Cys Lys His 
    1085                 1090                 1095             


Pro Glu  Ala Lys Arg Met Pro  Cys Ala Glu Asp Tyr  Leu Ser Val 
    1100                 1105                 1110             


Val Leu  Asn Gln Leu Cys Val  Leu His Glu Lys Thr  Pro Val Ser 
    1115                 1120                 1125             


Asp Arg  Val Thr Lys Cys Cys  Thr Glu Ser Leu Val  Asn Arg Arg 
    1130                 1135                 1140             


Pro Cys  Phe Ser Ala Leu Glu  Val Asp Glu Thr Tyr  Val Pro Lys 
    1145                 1150                 1155             


Glu Phe  Asn Ala Glu Thr Phe  Thr Phe His Ala Asp  Ile Cys Thr 
    1160                 1165                 1170             


Leu Ser  Glu Lys Glu Arg Gln  Ile Lys Lys Gln Thr  Ala Leu Val 
    1175                 1180                 1185             


Glu Leu  Val Lys His Lys Pro  Lys Ala Thr Lys Glu  Gln Leu Lys 
    1190                 1195                 1200             


Ala Val  Met Asp Asp Phe Ala  Ala Phe Val Glu Lys  Cys Cys Lys 
    1205                 1210                 1215             


Ala Asp  Asp Lys Glu Thr Cys  Phe Ala Glu Glu Gly  Lys Lys Leu 
    1220                 1225                 1230             


Val Ala  Ala Ser Gln Ala Ala  Leu Gly Leu 
    1235                 1240             


<210>  257
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  257

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ala Ala Ala Gln Thr Asn 
    210                 215                 220                 


Ala Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu 
                245                 250                 255     


Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile 
            260                 265                 270         


Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp 
        275                 280                 285             


His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly 
    290                 295                 300                 


Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu 
305                 310                 315                 320 


Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val 
                325                 330                 335     


Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro 
            340                 345                 350         


Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr 
        355                 360                 365             


Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe 
    370                 375                 380                 


Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro 
385                 390                 395                 400 


Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro 
                405                 410                 415     


Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu 
            420                 425                 430         


Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp 
        435                 440                 445             


Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr 
    450                 455                 460                 


Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser 
465                 470                 475                 480 


Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe 
                485                 490                 495     


Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly 
            500                 505                 510         


Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu 
        515                 520                 525             


Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu 
    530                 535                 540                 


Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His 
545                 550                 555                 560 


Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala 
                565                 570                 575     


Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly 
            580                 585                 590         


Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val 
        595                 600                 605             


Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val 
    610                 615                 620                 


Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
625                 630                 635                 


<210>  258
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  258

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ala Ala Ala Gln Thr Asn 
    210                 215                 220                 


Ala Ala Ala Ala Ser Ser Ala Ser Leu Glu Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu 
                245                 250                 255     


Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile 
            260                 265                 270         


Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp 
        275                 280                 285             


His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly 
    290                 295                 300                 


Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu 
305                 310                 315                 320 


Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val 
                325                 330                 335     


Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro 
            340                 345                 350         


Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr 
        355                 360                 365             


Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe 
    370                 375                 380                 


Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro 
385                 390                 395                 400 


Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro 
                405                 410                 415     


Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu 
            420                 425                 430         


Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp 
        435                 440                 445             


Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr 
    450                 455                 460                 


Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser 
465                 470                 475                 480 


Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe 
                485                 490                 495     


Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly 
            500                 505                 510         


Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu 
        515                 520                 525             


Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu 
    530                 535                 540                 


Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His 
545                 550                 555                 560 


Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala 
                565                 570                 575     


Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly 
            580                 585                 590         


Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val 
        595                 600                 605             


Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val 
    610                 615                 620                 


Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
625                 630                 635                 


<210>  259
<211>  1046
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  259

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Asp Asp 
385                 390                 395                 400 


Asp Asp Lys Ile Pro Gln Val Ser Pro Val Arg Ala Pro Ser Arg Arg 
                405                 410                 415     


His Gly Val Arg Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met 
            420                 425                 430         


Glu Met Arg Gln Leu Gln Arg Gly Pro Ala Glu Asn Leu Tyr Phe Gln 
        435                 440                 445             


Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His 
    450                 455                 460                 


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
465                 470                 475                 480 


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
                485                 490                 495     


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
            500                 505                 510         


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
        515                 520                 525             


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
    530                 535                 540                 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
545                 550                 555                 560 


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
                565                 570                 575     


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
            580                 585                 590         


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
        595                 600                 605             


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
    610                 615                 620                 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
625                 630                 635                 640 


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
                645                 650                 655     


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
            660                 665                 670         


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
        675                 680                 685             


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
    690                 695                 700                 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
705                 710                 715                 720 


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
                725                 730                 735     


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
            740                 745                 750         


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
        755                 760                 765             


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
    770                 775                 780                 


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
785                 790                 795                 800 


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
                805                 810                 815     


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
            820                 825                 830         


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
        835                 840                 845             


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
    850                 855                 860                 


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
865                 870                 875                 880 


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
                885                 890                 895     


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
            900                 905                 910         


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
        915                 920                 925             


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
    930                 935                 940                 


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
945                 950                 955                 960 


Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
                965                 970                 975     


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
            980                 985                 990         


Leu Val Lys His Lys Pro Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val 
        995                 1000                 1005             


Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp 
    1010                 1015                 1020             


Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala 
    1025                 1030                 1035             


Ala Ser  Gln Ala Ala Leu Gly  Leu 
    1040                 1045     


<210>  260
<211>  1041
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  260

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
385                 390                 395                 400 


Gln Val Ser Pro Val Arg Ala Pro Ser Arg Arg His Gly Val Arg Ala 
                405                 410                 415     


Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln Leu 
            420                 425                 430         


Gln Arg Gly Pro Ala Glu Asn Leu Tyr Phe Gln Gly Gly Ser Ser Gly 
        435                 440                 445             


Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val Ala 
    450                 455                 460                 


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
465                 470                 475                 480 


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
                485                 490                 495     


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
            500                 505                 510         


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
        515                 520                 525             


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
    530                 535                 540                 


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
545                 550                 555                 560 


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
                565                 570                 575     


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
            580                 585                 590         


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
        595                 600                 605             


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
    610                 615                 620                 


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
625                 630                 635                 640 


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
                645                 650                 655     


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
            660                 665                 670         


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
        675                 680                 685             


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
    690                 695                 700                 


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
705                 710                 715                 720 


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
                725                 730                 735     


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
            740                 745                 750         


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
        755                 760                 765             


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
    770                 775                 780                 


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
785                 790                 795                 800 


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
                805                 810                 815     


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
            820                 825                 830         


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
        835                 840                 845             


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
    850                 855                 860                 


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
865                 870                 875                 880 


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
                885                 890                 895     


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
            900                 905                 910         


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
        915                 920                 925             


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
    930                 935                 940                 


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
945                 950                 955                 960 


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
                965                 970                 975     


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
            980                 985                 990         


Pro Lys Ala Thr Lys Glu Gln Leu  Lys Ala Val Met Asp  Asp Phe Ala 
        995                 1000                 1005             


Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp Asp Lys  Glu Thr Cys 
    1010                 1015                 1020             


Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala Ala Ser  Gln Ala Ala 
    1025                 1030                 1035             


Leu Gly  Leu 
    1040     


<210>  261
<211>  1034
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  261

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Ile Pro 
385                 390                 395                 400 


Gln Val Ser Pro Val Arg Ala Pro Ser Arg Arg His Gly Val Arg Ala 
                405                 410                 415     


Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met Arg Gln Leu 
            420                 425                 430         


Gln Arg Gly Pro Ala Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
        435                 440                 445             


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
    450                 455                 460                 


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
465                 470                 475                 480 


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
                485                 490                 495     


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
            500                 505                 510         


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
        515                 520                 525             


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
    530                 535                 540                 


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
545                 550                 555                 560 


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
                565                 570                 575     


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
            580                 585                 590         


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
        595                 600                 605             


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
    610                 615                 620                 


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
625                 630                 635                 640 


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
                645                 650                 655     


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
            660                 665                 670         


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
        675                 680                 685             


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
    690                 695                 700                 


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
705                 710                 715                 720 


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
                725                 730                 735     


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
            740                 745                 750         


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
        755                 760                 765             


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
    770                 775                 780                 


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
785                 790                 795                 800 


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
                805                 810                 815     


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
            820                 825                 830         


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
        835                 840                 845             


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
    850                 855                 860                 


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
865                 870                 875                 880 


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
                885                 890                 895     


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
            900                 905                 910         


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
        915                 920                 925             


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
    930                 935                 940                 


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
945                 950                 955                 960 


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
                965                 970                 975     


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
            980                 985                 990         


Leu Lys Ala Val Met Asp Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys 
        995                 1000                 1005             


Lys Ala  Asp Asp Lys Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys 
    1010                 1015                 1020             


Leu Val  Ala Ala Ser Gln Ala  Ala Leu Gly Leu 
    1025                 1030                 


<210>  262
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  262

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Arg His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asp Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys 
                325                 330                 335     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            340                 345                 350         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
        355                 360                 365             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    370                 375                 380                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
385                 390                 395                 400 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                405                 410                 415     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            420                 425                 430         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        435                 440                 445             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    450                 455                 460                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
465                 470                 475                 480 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                485                 490                 495     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            500                 505                 510         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        515                 520                 525             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    530                 535                 540                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
545                 550                 555                 560 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                565                 570                 575     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            580                 585                 590         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        595                 600                 605             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    610                 615                 620                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
625                 630                 635                 640 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                645                 650                 655     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            660                 665                 670         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        675                 680                 685             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    690                 695                 700                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
705                 710                 715                 720 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                725                 730                 735     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            740                 745                 750         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        755                 760                 765             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    770                 775                 780                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
785                 790                 795                 800 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                805                 810                 815     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            820                 825                 830         


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        835                 840                 845             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    850                 855                 860                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
865                 870                 875                 880 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                885                 890                 895     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            900                 905                 910         


Ala Ala Leu Gly Leu 
        915         


<210>  263
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  263

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Ser His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Arg Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys 
                325                 330                 335     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            340                 345                 350         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
        355                 360                 365             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    370                 375                 380                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
385                 390                 395                 400 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                405                 410                 415     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            420                 425                 430         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        435                 440                 445             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    450                 455                 460                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
465                 470                 475                 480 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                485                 490                 495     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            500                 505                 510         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        515                 520                 525             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    530                 535                 540                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
545                 550                 555                 560 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                565                 570                 575     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            580                 585                 590         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        595                 600                 605             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    610                 615                 620                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
625                 630                 635                 640 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                645                 650                 655     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            660                 665                 670         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        675                 680                 685             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    690                 695                 700                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
705                 710                 715                 720 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                725                 730                 735     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            740                 745                 750         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        755                 760                 765             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    770                 775                 780                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
785                 790                 795                 800 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                805                 810                 815     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            820                 825                 830         


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        835                 840                 845             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    850                 855                 860                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
865                 870                 875                 880 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                885                 890                 895     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            900                 905                 910         


Ala Ala Leu Gly Leu 
        915         


<210>  264
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  264

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Lys His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys 
                325                 330                 335     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            340                 345                 350         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
        355                 360                 365             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    370                 375                 380                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
385                 390                 395                 400 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                405                 410                 415     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            420                 425                 430         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        435                 440                 445             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    450                 455                 460                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
465                 470                 475                 480 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                485                 490                 495     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            500                 505                 510         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        515                 520                 525             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    530                 535                 540                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
545                 550                 555                 560 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                565                 570                 575     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            580                 585                 590         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        595                 600                 605             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    610                 615                 620                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
625                 630                 635                 640 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                645                 650                 655     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            660                 665                 670         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        675                 680                 685             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    690                 695                 700                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
705                 710                 715                 720 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                725                 730                 735     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            740                 745                 750         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        755                 760                 765             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    770                 775                 780                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
785                 790                 795                 800 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                805                 810                 815     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            820                 825                 830         


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        835                 840                 845             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    850                 855                 860                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
865                 870                 875                 880 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                885                 890                 895     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            900                 905                 910         


Ala Ala Leu Gly Leu 
        915         


<210>  265
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  265

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Ser His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Arg Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Lys Phe Gln Asp Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Lys 
305                 310                 315                 320 


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys 
                325                 330                 335     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            340                 345                 350         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
        355                 360                 365             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    370                 375                 380                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
385                 390                 395                 400 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                405                 410                 415     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            420                 425                 430         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        435                 440                 445             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    450                 455                 460                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
465                 470                 475                 480 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                485                 490                 495     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            500                 505                 510         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        515                 520                 525             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    530                 535                 540                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
545                 550                 555                 560 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                565                 570                 575     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            580                 585                 590         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        595                 600                 605             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    610                 615                 620                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
625                 630                 635                 640 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                645                 650                 655     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            660                 665                 670         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        675                 680                 685             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    690                 695                 700                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
705                 710                 715                 720 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                725                 730                 735     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            740                 745                 750         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        755                 760                 765             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    770                 775                 780                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
785                 790                 795                 800 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                805                 810                 815     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            820                 825                 830         


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        835                 840                 845             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    850                 855                 860                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
865                 870                 875                 880 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                885                 890                 895     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            900                 905                 910         


Ala Ala Leu Gly Leu 
        915         


<210>  266
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  266

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Arg His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Trp Phe Gln His Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asp Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys 
                325                 330                 335     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            340                 345                 350         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
        355                 360                 365             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    370                 375                 380                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
385                 390                 395                 400 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                405                 410                 415     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            420                 425                 430         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        435                 440                 445             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    450                 455                 460                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
465                 470                 475                 480 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                485                 490                 495     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            500                 505                 510         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        515                 520                 525             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    530                 535                 540                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
545                 550                 555                 560 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                565                 570                 575     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            580                 585                 590         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        595                 600                 605             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    610                 615                 620                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
625                 630                 635                 640 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                645                 650                 655     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            660                 665                 670         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        675                 680                 685             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    690                 695                 700                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
705                 710                 715                 720 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                725                 730                 735     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            740                 745                 750         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        755                 760                 765             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    770                 775                 780                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
785                 790                 795                 800 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                805                 810                 815     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            820                 825                 830         


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        835                 840                 845             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    850                 855                 860                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
865                 870                 875                 880 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                885                 890                 895     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            900                 905                 910         


Ala Ala Leu Gly Leu 
        915         


<210>  267
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  267

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Asn Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


Arg His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asp Phe Lys Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Lys Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asp Ser Tyr Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Asn 
305                 310                 315                 320 


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys 
                325                 330                 335     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            340                 345                 350         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe 
        355                 360                 365             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    370                 375                 380                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
385                 390                 395                 400 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                405                 410                 415     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            420                 425                 430         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        435                 440                 445             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    450                 455                 460                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
465                 470                 475                 480 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                485                 490                 495     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            500                 505                 510         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        515                 520                 525             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    530                 535                 540                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
545                 550                 555                 560 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                565                 570                 575     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            580                 585                 590         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        595                 600                 605             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    610                 615                 620                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
625                 630                 635                 640 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                645                 650                 655     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            660                 665                 670         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        675                 680                 685             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    690                 695                 700                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
705                 710                 715                 720 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                725                 730                 735     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            740                 745                 750         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        755                 760                 765             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    770                 775                 780                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
785                 790                 795                 800 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                805                 810                 815     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            820                 825                 830         


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        835                 840                 845             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    850                 855                 860                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
865                 870                 875                 880 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                885                 890                 895     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            900                 905                 910         


Ala Ala Leu Gly Leu 
        915         


<210>  268
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  268

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Asp Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  269
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  269

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Asp Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  270
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  270

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asp Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Asp Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  271
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  271

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Pro Asp Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Asp Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  272
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  272

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Pro Asp Ile Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Asp Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  273
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  273

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met Lys Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  274
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  274

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Glu Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  275
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  275

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Glu Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  276
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  276

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Asp Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  277
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  277

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Lys Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  278
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  278

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Glu Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  279
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  279

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Gly Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  280
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  280

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Gly Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  281
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  281

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Glu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  282
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  282

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Arg Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  283
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  283

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Glu Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  284
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  284

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Glu Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  285
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  285

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asn Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  286
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  286

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Cys Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  287
<211>  1011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  287

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu Gly Gly Gly Gly His  His His His His His  His His His 
        995                 1000                 1005             


His Leu  Glu 
    1010     


<210>  288
<211>  1036
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  288

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Ser Val Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp Arg 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Ala Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Arg 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Leu Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Ser Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Arg 
        195                 200                 205             


Ser Phe Glu His Pro Val Arg Gly Val Arg Arg Pro Ala Asn Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Arg Lys Leu Ala Lys Ile Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Tyr Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Ile Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Asp Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asn Lys Phe Pro Pro Gln Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Glu Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Thr Tyr Thr Val Thr 
        355                 360                 365             


Ala Lys Ala Pro Gly Phe Asp Pro Gln Thr Glu Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe Tyr Leu Lys Arg Ser Ile Ser 
385                 390                 395                 400 


Gln Val Ser Ser Val Gly Arg Ala Pro Ser Arg Arg His Gly Val Gly 
                405                 410                 415     


Ala Lys Ala Gln Pro Gln Ala Ala Arg Lys Lys Glu Met Glu Met Arg 
            420                 425                 430         


Gln Leu Gln Arg Gly Pro Ala Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        435                 440                 445             


Ser Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
    450                 455                 460                 


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
465                 470                 475                 480 


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
                485                 490                 495     


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
            500                 505                 510         


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
        515                 520                 525             


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
    530                 535                 540                 


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
545                 550                 555                 560 


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
                565                 570                 575     


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
            580                 585                 590         


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
        595                 600                 605             


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
    610                 615                 620                 


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
625                 630                 635                 640 


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
                645                 650                 655     


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
            660                 665                 670         


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
        675                 680                 685             


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
    690                 695                 700                 


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
705                 710                 715                 720 


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
                725                 730                 735     


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
            740                 745                 750         


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
        755                 760                 765             


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
    770                 775                 780                 


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
785                 790                 795                 800 


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
                805                 810                 815     


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
            820                 825                 830         


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
        835                 840                 845             


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
    850                 855                 860                 


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
865                 870                 875                 880 


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
                885                 890                 895     


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
            900                 905                 910         


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
        915                 920                 925             


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
    930                 935                 940                 


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
945                 950                 955                 960 


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
                965                 970                 975     


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
            980                 985                 990         


Glu Gln Leu Lys Ala Val Met Asp  Asp Phe Ala Ala Phe  Val Glu Lys 
        995                 1000                 1005             


Cys Cys  Lys Ala Asp Asp Lys  Glu Thr Cys Phe Ala  Glu Glu Gly 
    1010                 1015                 1020             


Lys Lys  Leu Val Ala Ala Ser  Gln Ala Ala Leu Gly  Leu 
    1025                 1030                 1035     


<210>  289
<211>  1040
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  289

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Met Leu Tyr 
1               5                   10                  15      


Lys Val His Asn Glu Cys Pro His Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Lys Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp Tyr 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Arg 
                85                  90                  95      


Leu Val Glu Asp Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Ala Gln Glu Arg Asp Ile Ser Gly Tyr 
        115                 120                 125             


Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe 
    130                 135                 140                 


Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Asn Gly Gly Pro 
145                 150                 155                 160 


Asn His His Phe Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro 
                165                 170                 175     


Glu Thr Gln Ala Val Ile Gln Trp Ile Arg Ser Phe Asn Phe Val Leu 
            180                 185                 190         


Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp 
        195                 200                 205             


Lys Ser Leu Gly His Arg Val Arg Gly Phe Arg Arg Thr Ala Asn Thr 
    210                 215                 220                 


Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Ile Tyr Ser 
225                 230                 235                 240 


Tyr Ala His Gly Trp Met His Gln Gly Trp Asn Cys Gly Asp Tyr Phe 
                245                 250                 255     


Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly 
            260                 265                 270         


Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu 
        275                 280                 285             


Glu Leu Ser Cys Asp Lys Phe Pro Leu Gln Gly Glu Leu Gln Arg Glu 
    290                 295                 300                 


Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His 
305                 310                 315                 320 


Gln Gly Ile Lys Gly Met Val Arg Asp Glu Asn Tyr Asn Asn Leu Ala 
                325                 330                 335     


Asp Ala Val Ile Ser Val Gly Gly Ile Asn His Asp Val Thr Ser Gly 
            340                 345                 350         


Ala His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Thr Tyr Thr Val 
        355                 360                 365             


Thr Ala Thr Ala Pro Gly Phe Asp Pro Glu Thr Val Ser Val Thr Val 
    370                 375                 380                 


Gly Pro Ala Glu Pro Lys Leu Val Asn Phe Gln Leu Lys Arg Ser Thr 
385                 390                 395                 400 


Pro Gln Ala Ala Pro Lys Arg Arg Ile Pro Asn Ser Gly His Arg Gly 
                405                 410                 415     


Arg Val Leu Pro Lys Lys Val Gln Pro Arg Ala Ala Arg Lys Lys Glu 
            420                 425                 430         


Thr Met Met Lys Gln Pro Gln Arg Gly Pro Ala Gly Ser Ser Gly Gly 
        435                 440                 445             


Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val Ala His 
    450                 455                 460                 


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
465                 470                 475                 480 


Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys 
                485                 490                 495     


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
            500                 505                 510         


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
        515                 520                 525             


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
    530                 535                 540                 


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
545                 550                 555                 560 


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
                565                 570                 575     


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
            580                 585                 590         


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
        595                 600                 605             


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
    610                 615                 620                 


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
625                 630                 635                 640 


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
                645                 650                 655     


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
            660                 665                 670         


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
        675                 680                 685             


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
    690                 695                 700                 


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
705                 710                 715                 720 


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
                725                 730                 735     


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
            740                 745                 750         


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
        755                 760                 765             


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
    770                 775                 780                 


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
785                 790                 795                 800 


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
                805                 810                 815     


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
            820                 825                 830         


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
        835                 840                 845             


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
    850                 855                 860                 


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
865                 870                 875                 880 


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
                885                 890                 895     


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
            900                 905                 910         


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
        915                 920                 925             


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
    930                 935                 940                 


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu 
945                 950                 955                 960 


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
                965                 970                 975     


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
            980                 985                 990         


Lys Ala Thr Lys Glu Gln Leu Lys  Ala Val Met Asp Asp  Phe Ala Ala 
        995                 1000                 1005             


Phe Val  Glu Lys Cys Cys Lys  Ala Asp Asp Lys Glu  Thr Cys Phe 
    1010                 1015                 1020             


Ala Glu  Glu Gly Lys Lys Leu  Val Ala Ala Ser Gln  Ala Ala Leu 
    1025                 1030                 1035             


Gly Leu  
    1040 


<210>  290
<211>  1034
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  290

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val His Asn Gln Cys Pro Asp Ile Thr Arg Leu Tyr Asn Ile Gly 
            20                  25                  30          


Arg Ser Val Lys Gly Arg Tyr Leu Tyr Val Leu Glu Phe Ser Asp Tyr 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Leu Arg 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Met Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Phe Tyr Tyr Asn Ser Lys Asn Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Gln Trp Ile Arg Ser Leu Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Met His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Leu Glu His Arg Phe Arg Gly Pro His Arg Thr Ser Asn Ser Pro 
    210                 215                 220                 


Thr Pro Asp Asp Glu Leu Phe Gln Thr Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met His Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Arg Gln Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Ser Asn Asn Leu Thr Gly 
                325                 330                 335     


Ala Val Ile Ser Val Thr Gly Ile Asn His Asp Val Thr Ser Gly Glu 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Thr Tyr Ser Val Thr 
        355                 360                 365             


Ala Lys Ala Pro Gly Tyr Asp Pro Lys Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Gly Pro Thr Val Val Asp Phe Gln Leu Lys Arg Ser Ser Ser 
385                 390                 395                 400 


Gln Val Tyr Pro Val Gln Arg Ala Pro Gly Arg Gly Gln Gly Gly Arg 
                405                 410                 415     


Ala Lys Gln Pro Arg Thr Ser Arg Lys Lys Asp Pro Ala Thr Lys Arg 
            420                 425                 430         


His Arg Gly Pro Ala Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
        435                 440                 445             


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
    450                 455                 460                 


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
465                 470                 475                 480 


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
                485                 490                 495     


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
            500                 505                 510         


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
        515                 520                 525             


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
    530                 535                 540                 


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
545                 550                 555                 560 


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
                565                 570                 575     


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
            580                 585                 590         


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
        595                 600                 605             


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
    610                 615                 620                 


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
625                 630                 635                 640 


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
                645                 650                 655     


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
            660                 665                 670         


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
        675                 680                 685             


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
    690                 695                 700                 


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
705                 710                 715                 720 


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
                725                 730                 735     


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
            740                 745                 750         


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
        755                 760                 765             


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
    770                 775                 780                 


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
785                 790                 795                 800 


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
                805                 810                 815     


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
            820                 825                 830         


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
        835                 840                 845             


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
    850                 855                 860                 


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
865                 870                 875                 880 


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
                885                 890                 895     


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
            900                 905                 910         


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
        915                 920                 925             


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
    930                 935                 940                 


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
945                 950                 955                 960 


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
                965                 970                 975     


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
            980                 985                 990         


Leu Lys Ala Val Met Asp Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys 
        995                 1000                 1005             


Lys Ala  Asp Asp Lys Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys 
    1010                 1015                 1020             


Leu Val  Ala Ala Ser Gln Ala  Ala Leu Gly Leu 
    1025                 1030                 


<210>  291
<211>  1033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  291

Val Thr Phe Gln His His Arg Tyr Asp Asp Leu Met Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val His Asn Glu Cys Pro His Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Lys Gly Arg His Leu Tyr Ala Leu Glu Phe Ser Asp Phe 
        35                  40                  45              


Pro Gly Met His Glu Leu Leu Glu Pro Glu Phe Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Ile Gln Leu Cys 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Tyr Arg Gln Arg Asn Glu Arg Ile Val Arg 
                85                  90                  95      


Leu Ile His Asn Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Asp Gln Gly Pro Asp Thr Asn Gly Tyr Leu 
        115                 120                 125             


Thr Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Met Tyr Tyr Asn Glu Lys Ser Gly Gly Pro Asn 
145                 150                 155                 160 


His His Ile Pro Leu Pro Asp Asn Trp Arg Asn Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Glu Ala Ile Ile Gln Trp Met Glu Ser Ile Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Arg Glu His Arg Val Arg Gly Phe Arg Arg Thr Ala Asp Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Arg Lys Leu Ala Lys Gly Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met His Leu Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Val Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Asp Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asn Lys Phe Pro Arg Gln Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Leu Glu Ala Leu Ile Ser Phe Leu Glu Glu Val His His 
305                 310                 315                 320 


Gly Ile Lys Gly Met Ile Leu Asp Glu Asn Asn Asn Gly Ile Ala Gly 
                325                 330                 335     


Ala Val Ile Ser Ile Ser Gly Ile Ala His Asp Val Thr Ser Gly Lys 
            340                 345                 350         


Gln Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Thr Tyr Val Val Thr 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Gly Ser Glu Thr Met Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Lys Gln Val Asn Phe Gln Leu Ser Ile Asp Thr Thr 
385                 390                 395                 400 


Lys Glu Ser Thr Glu Gln Lys Thr Pro Val Lys Ala Pro Ser Gly Lys 
                405                 410                 415     


Thr Leu Leu Lys Lys Met Ala Ser Arg Glu Val Gly Lys Glu Thr Arg 
            420                 425                 430         


Arg Ser Arg Pro Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
        435                 440                 445             


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
    450                 455                 460                 


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
465                 470                 475                 480 


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
                485                 490                 495     


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
            500                 505                 510         


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
        515                 520                 525             


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
    530                 535                 540                 


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
545                 550                 555                 560 


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
                565                 570                 575     


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
            580                 585                 590         


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
        595                 600                 605             


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
    610                 615                 620                 


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
625                 630                 635                 640 


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
                645                 650                 655     


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
            660                 665                 670         


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
        675                 680                 685             


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
    690                 695                 700                 


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
705                 710                 715                 720 


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
                725                 730                 735     


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
            740                 745                 750         


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
        755                 760                 765             


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
    770                 775                 780                 


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
785                 790                 795                 800 


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
                805                 810                 815     


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
            820                 825                 830         


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
        835                 840                 845             


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
    850                 855                 860                 


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
865                 870                 875                 880 


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
                885                 890                 895     


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
            900                 905                 910         


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
        915                 920                 925             


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
    930                 935                 940                 


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
945                 950                 955                 960 


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
                965                 970                 975     


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
            980                 985                 990         


Lys Ala Val Met Asp Asp Phe Ala  Ala Phe Val Glu Lys  Cys Cys Lys 
        995                 1000                 1005             


Ala Asp  Asp Lys Glu Thr Cys  Phe Ala Glu Glu Gly  Lys Lys Leu 
    1010                 1015                 1020             


Val Ala  Ala Ser Gln Ala Ala  Leu Gly Leu 
    1025                 1030             


<210>  292
<211>  1030
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  292

Leu Ser Phe Leu His His Arg Tyr Glu Glu Met Val Gln Ala Leu Phe 
1               5                   10                  15      


Arg Val Gln Ser Gln Cys Pro Tyr Val Thr Arg Ile Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp Tyr 
        35                  40                  45              


Pro Gly Ile His Glu Ala Leu Glu Pro Glu Phe Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Tyr Arg Arg Gly Asn Glu Arg Ile Ser Arg 
                85                  90                  95      


Leu Ile His Asp Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Lys Gln Gly Pro Asp Ser Asn Gly Tyr Leu 
        115                 120                 125             


Thr Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Phe Met Tyr Tyr Ser Arg Glu Ile Ser Gly Pro Asn 
145                 150                 155                 160 


His His Ile Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Leu Ala Val Ile Gln Trp Ile Ser Ser Tyr Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Gln Asp Gln Arg Phe Arg Ser His Arg Arg Thr Val Asn Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Thr Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met His Arg Gly Trp Asn Cys Gly Asp Tyr Phe Ala 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu Tyr Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asn Lys Phe Pro Pro Glu Glu Asp Leu Glu Arg Gln Trp 
    290                 295                 300                 


Met Ala Asn Arg Glu Ala Leu Val Ala Phe Met Glu Glu Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Ser Asp Glu Asn Asn Asn Gly Ile Ala Gly 
                325                 330                 335     


Ala Val Ile Ser Val Gln Gly Ile Ser His Asp Ile Thr Ser Gly Asp 
            340                 345                 350         


Met Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Thr Tyr Thr Val Thr 
        355                 360                 365             


Ala Ser Ala Glu Gly Tyr Gln Pro Gln Thr Val Thr Thr Thr Val Gly 
    370                 375                 380                 


Pro Ala Ala Pro Ser Leu Val His Phe Gln Leu Lys Gln Asp Val Val 
385                 390                 395                 400 


Lys Lys Ala Pro Glu Arg Lys Ala Ser Gly Thr Arg Thr Asn Asn Lys 
                405                 410                 415     


Ala Leu Gln Lys Lys Val Val Pro Arg Ala Thr Arg Arg Gly Thr Gln 
            420                 425                 430         


Arg Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His 
        435                 440                 445             


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
    450                 455                 460                 


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
465                 470                 475                 480 


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
                485                 490                 495     


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
            500                 505                 510         


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
        515                 520                 525             


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
    530                 535                 540                 


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
545                 550                 555                 560 


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
                565                 570                 575     


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
            580                 585                 590         


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
        595                 600                 605             


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
    610                 615                 620                 


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
625                 630                 635                 640 


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
                645                 650                 655     


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
            660                 665                 670         


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
        675                 680                 685             


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
    690                 695                 700                 


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
705                 710                 715                 720 


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
                725                 730                 735     


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
            740                 745                 750         


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
        755                 760                 765             


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
    770                 775                 780                 


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
785                 790                 795                 800 


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
                805                 810                 815     


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
            820                 825                 830         


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
        835                 840                 845             


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
    850                 855                 860                 


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
865                 870                 875                 880 


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
                885                 890                 895     


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
            900                 905                 910         


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
        915                 920                 925             


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
    930                 935                 940                 


Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
945                 950                 955                 960 


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
                965                 970                 975     


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
            980                 985                 990         


Met Asp Asp Phe Ala Ala Phe Val  Glu Lys Cys Cys Lys  Ala Asp Asp 
        995                 1000                 1005             


Lys Glu  Thr Cys Phe Ala Glu  Glu Gly Lys Lys Leu  Val Ala Ala 
    1010                 1015                 1020             


Ser Gln  Ala Ala Leu Gly Leu  
    1025                 1030 


<210>  293
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  293

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Lys Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Gln Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  294
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  294

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Asp Ala 
385                 390                 395                 400 


His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 
                405                 410                 415     


Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys 
            420                 425                 430         


Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 
        435                 440                 445             


Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 
    450                 455                 460                 


His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 
465                 470                 475                 480 


Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 
                485                 490                 495     


Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 
            500                 505                 510         


Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 
        515                 520                 525             


Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 
    530                 535                 540                 


Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 
545                 550                 555                 560 


Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 
                565                 570                 575     


Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 
            580                 585                 590         


Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 
        595                 600                 605             


Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 
    610                 615                 620                 


Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 
625                 630                 635                 640 


Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 
                645                 650                 655     


Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 
            660                 665                 670         


Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 
        675                 680                 685             


Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 
    690                 695                 700                 


Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 
705                 710                 715                 720 


Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 
                725                 730                 735     


Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 
            740                 745                 750         


Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 
        755                 760                 765             


Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 
    770                 775                 780                 


Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 
785                 790                 795                 800 


Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 
                805                 810                 815     


Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 
            820                 825                 830         


Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 
        835                 840                 845             


Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 
    850                 855                 860                 


Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 
865                 870                 875                 880 


Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 
                885                 890                 895     


Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 
            900                 905                 910         


Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 
        915                 920                 925             


Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 
    930                 935                 940                 


Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 
945                 950                 955                 960 


Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 
                965                 970                 975     


Ser Gln Ala Ala Leu Gly Leu 
            980             


<210>  295
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  295

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu 
                405                 410                 415     


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
            420                 425                 430         


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
        435                 440                 445             


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
    450                 455                 460                 


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
465                 470                 475                 480 


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
                485                 490                 495     


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
            500                 505                 510         


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
        515                 520                 525             


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
    530                 535                 540                 


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
545                 550                 555                 560 


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
                565                 570                 575     


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
            580                 585                 590         


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
        595                 600                 605             


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
    610                 615                 620                 


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
625                 630                 635                 640 


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
                645                 650                 655     


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
            660                 665                 670         


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
        675                 680                 685             


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
    690                 695                 700                 


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
705                 710                 715                 720 


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
                725                 730                 735     


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
            740                 745                 750         


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
        755                 760                 765             


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
    770                 775                 780                 


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
785                 790                 795                 800 


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
                805                 810                 815     


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
            820                 825                 830         


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
        835                 840                 845             


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
    850                 855                 860                 


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
865                 870                 875                 880 


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
                885                 890                 895     


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
            900                 905                 910         


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
        915                 920                 925             


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
    930                 935                 940                 


Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 
945                 950                 955                 960 


Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 
                965                 970                 975     


Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985         


<210>  296
<211>  991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  296

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg 
                405                 410                 415     


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
            420                 425                 430         


Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu 
        435                 440                 445             


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
    450                 455                 460                 


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
465                 470                 475                 480 


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
                485                 490                 495     


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
            500                 505                 510         


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
        515                 520                 525             


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
    530                 535                 540                 


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
545                 550                 555                 560 


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
                565                 570                 575     


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
            580                 585                 590         


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
        595                 600                 605             


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
    610                 615                 620                 


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
625                 630                 635                 640 


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
                645                 650                 655     


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
            660                 665                 670         


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
        675                 680                 685             


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
    690                 695                 700                 


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
705                 710                 715                 720 


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
                725                 730                 735     


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
            740                 745                 750         


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
        755                 760                 765             


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
    770                 775                 780                 


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
785                 790                 795                 800 


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
                805                 810                 815     


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
            820                 825                 830         


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
        835                 840                 845             


Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 
    850                 855                 860                 


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
865                 870                 875                 880 


Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 
                885                 890                 895     


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
            900                 905                 910         


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
        915                 920                 925             


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
    930                 935                 940                 


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
945                 950                 955                 960 


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
                965                 970                 975     


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985                 990     


<210>  297
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  297

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Gly Tyr Ile Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Ile Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Met 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Leu 
            260                 265                 270         


Gln Asp Phe Ile Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  298
<211>  990
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  298

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe 
                405                 410                 415     


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
            420                 425                 430         


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
        435                 440                 445             


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
    450                 455                 460                 


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
465                 470                 475                 480 


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
                485                 490                 495     


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
            500                 505                 510         


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
        515                 520                 525             


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
    530                 535                 540                 


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
545                 550                 555                 560 


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
                565                 570                 575     


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
            580                 585                 590         


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
        595                 600                 605             


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
    610                 615                 620                 


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
625                 630                 635                 640 


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
                645                 650                 655     


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
            660                 665                 670         


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
        675                 680                 685             


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
    690                 695                 700                 


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
705                 710                 715                 720 


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
                725                 730                 735     


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
            740                 745                 750         


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
        755                 760                 765             


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
    770                 775                 780                 


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
785                 790                 795                 800 


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
                805                 810                 815     


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
            820                 825                 830         


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
        835                 840                 845             


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln 
    850                 855                 860                 


Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 
865                 870                 875                 880 


Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu 
                885                 890                 895     


Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 
            900                 905                 910         


Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 
        915                 920                 925             


Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 
    930                 935                 940                 


Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 
945                 950                 955                 960 


Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 
                965                 970                 975     


Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985                 990 


<210>  299
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  299

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val 
                405                 410                 415     


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
            420                 425                 430         


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
        435                 440                 445             


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
    450                 455                 460                 


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
465                 470                 475                 480 


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
                485                 490                 495     


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
            500                 505                 510         


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
        515                 520                 525             


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
    530                 535                 540                 


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
545                 550                 555                 560 


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
                565                 570                 575     


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
            580                 585                 590         


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
        595                 600                 605             


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
    610                 615                 620                 


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
625                 630                 635                 640 


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
                645                 650                 655     


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
            660                 665                 670         


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
        675                 680                 685             


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
    690                 695                 700                 


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
705                 710                 715                 720 


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
                725                 730                 735     


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
            740                 745                 750         


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
        755                 760                 765             


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
    770                 775                 780                 


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
785                 790                 795                 800 


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
                805                 810                 815     


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
            820                 825                 830         


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
        835                 840                 845             


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
    850                 855                 860                 


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
865                 870                 875                 880 


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
                885                 890                 895     


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
            900                 905                 910         


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
        915                 920                 925             


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
    930                 935                 940                 


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
945                 950                 955                 960 


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
                965                 970                 975     


Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 
            980                 985                 990         


Gly Leu 
        


<210>  300
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  300

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His 
                405                 410                 415     


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
            420                 425                 430         


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro 
        435                 440                 445             


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
    450                 455                 460                 


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
465                 470                 475                 480 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
                485                 490                 495     


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
            500                 505                 510         


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
        515                 520                 525             


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
    530                 535                 540                 


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
545                 550                 555                 560 


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
                565                 570                 575     


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
            580                 585                 590         


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
        595                 600                 605             


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
    610                 615                 620                 


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
625                 630                 635                 640 


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
                645                 650                 655     


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
            660                 665                 670         


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
        675                 680                 685             


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
    690                 695                 700                 


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
705                 710                 715                 720 


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
                725                 730                 735     


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
            740                 745                 750         


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
        755                 760                 765             


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
    770                 775                 780                 


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
785                 790                 795                 800 


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
                805                 810                 815     


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
            820                 825                 830         


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
        835                 840                 845             


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
    850                 855                 860                 


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
865                 870                 875                 880 


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
                885                 890                 895     


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
            900                 905                 910         


Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
        915                 920                 925             


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
    930                 935                 940                 


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
945                 950                 955                 960 


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
                965                 970                 975     


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
            980                 985                 990         


Gln Ala Ala Leu Gly Leu 
        995             


<210>  301
<211>  1010
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  301

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val 
            420                 425                 430         


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
        435                 440                 445             


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His 
    450                 455                 460                 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
465                 470                 475                 480 


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
                485                 490                 495     


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
            500                 505                 510         


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
        515                 520                 525             


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
    530                 535                 540                 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
545                 550                 555                 560 


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
                565                 570                 575     


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
            580                 585                 590         


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
        595                 600                 605             


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
    610                 615                 620                 


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
625                 630                 635                 640 


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
                645                 650                 655     


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
            660                 665                 670         


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
        675                 680                 685             


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
    690                 695                 700                 


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
705                 710                 715                 720 


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
                725                 730                 735     


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
            740                 745                 750         


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
        755                 760                 765             


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
    770                 775                 780                 


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
785                 790                 795                 800 


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
                805                 810                 815     


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
            820                 825                 830         


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
        835                 840                 845             


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
    850                 855                 860                 


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
865                 870                 875                 880 


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
                885                 890                 895     


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
            900                 905                 910         


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
        915                 920                 925             


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
    930                 935                 940                 


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
945                 950                 955                 960 


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
                965                 970                 975     


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
            980                 985                 990         


Phe Ala Glu Glu Gly Lys Lys Leu  Val Ala Ala Ser Gln  Ala Ala Leu 
        995                 1000                 1005             


Gly Leu  
    1010 


<210>  302
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  302

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  303
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  303

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  304
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  304

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Asn Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  305
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  305

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ile Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  306
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  306

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Phe Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  307
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  307

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  308
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  308

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Tyr Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  309
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  309

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Tyr Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  310
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  310

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asp Ser Asn Gly Tyr Leu 
        115                 120                 125             


Thr Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  311
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  311

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Thr Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  312
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  312

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Asp Arg Asp Ile Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  313
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  313

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asp Ile Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  314
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  314

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asp Ser Ile Gly Tyr Leu 
        115                 120                 125             


Thr Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  315
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  315

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asp Ala Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  316
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  316

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Ala Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  317
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  317

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asp Ala Asn Gly Tyr Leu 
        115                 120                 125             


Thr Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  318
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  318

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Glu Arg Asp Val Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  319
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  319

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Ser Thr Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  320
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  320

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Ile Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Ile Ile Arg Trp Leu His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Leu 
            260                 265                 270         


Gln Asp Phe Ile Tyr Leu His Thr Asn Cys Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  321
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  321

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Ala Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Leu His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Ala 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  322
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  322

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Thr Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  323
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  323

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Gly Tyr Ile Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Ile Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Met 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Leu 
            260                 265                 270         


Gln Asp Phe Ile Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  324
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  324

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Met Tyr Ile Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Ile Ile Arg Trp Phe His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Leu 
            260                 265                 270         


Gln Asp Phe Leu Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  325
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  325

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Tyr Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Thr Tyr Leu His Thr Asn Cys Phe Leu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  326
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  326

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Ala Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Tyr Ile Arg Trp Leu His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Ala 
            260                 265                 270         


Gln Asp Phe Thr Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  327
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  327

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Tyr Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Thr Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  328
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  328

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Tyr Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Tyr Ile Arg Trp Leu His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Ile 
            260                 265                 270         


Gln Asp Phe Thr Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  329
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  329

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Thr Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  330
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  330

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Ala Tyr Leu Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Leu His Ser Phe Asn Phe Val Leu Met 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Leu 
            260                 265                 270         


Gln Asp Phe Ile Tyr Leu His Thr Asn Thr Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  331
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  331

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Ile Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Ile Ile Arg Trp Leu His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Leu 
            260                 265                 270         


Gln Asp Phe Ile Tyr Leu His Thr Asn Thr Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  332
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  332

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Gly Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Met 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Met Tyr Leu His Thr Asn Thr Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  333
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  333

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Gly Tyr Ile Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Ile Ile Arg Trp Gln His Ser Phe Asn Phe Val Leu Gln 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Ile Tyr Leu His Thr Asn Ser Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  334
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  334

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Trp Tyr Leu His Thr Asn Cys Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  335
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  335

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Gly Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Met 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Trp Tyr Leu His Thr Asn Cys Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  336
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  336

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Ala Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Met 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Ile Tyr Leu His Thr Asn Cys Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  337
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  337

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Trp Tyr Leu His Thr Asn Thr Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  338
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  338

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Gly Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Trp Tyr Leu His Thr Asn Thr Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  339
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  339

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Trp Tyr Leu His Thr Asn Leu Phe Val Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  340
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  340

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  341
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  341

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Phe Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Gln 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Glu Asn 
385                 390                 395                 400 


Leu Tyr Phe Gln Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415     


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
            420                 425                 430         


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
        435                 440                 445             


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
    450                 455                 460                 


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
465                 470                 475                 480 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
                485                 490                 495     


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
            500                 505                 510         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
        515                 520                 525             


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
    530                 535                 540                 


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
545                 550                 555                 560 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
                565                 570                 575     


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
            580                 585                 590         


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
        595                 600                 605             


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
    610                 615                 620                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
625                 630                 635                 640 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
                645                 650                 655     


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            660                 665                 670         


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
        675                 680                 685             


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
    690                 695                 700                 


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
705                 710                 715                 720 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
                725                 730                 735     


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
            740                 745                 750         


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
        755                 760                 765             


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
    770                 775                 780                 


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
785                 790                 795                 800 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
                805                 810                 815     


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
            820                 825                 830         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
        835                 840                 845             


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
    850                 855                 860                 


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
865                 870                 875                 880 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
                885                 890                 895     


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
            900                 905                 910         


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
        915                 920                 925             


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
    930                 935                 940                 


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
945                 950                 955                 960 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
                965                 970                 975     


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
            980                 985                 990         


Val Ala Ala Ser Gln Ala Ala Leu  Gly Leu 
        995                 1000         


<210>  342
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  342

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Ala Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  343
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  343

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Ala Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  344
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  344

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Ala Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  345
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  345

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Ala Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  346
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  346

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Ala Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  347
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  347

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ala Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  348
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  348

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Ala Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  349
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  349

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Ala Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  350
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  350

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Ala Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  351
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  351

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Ala Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  352
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  352

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Ala Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  353
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  353

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Ala Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  354
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  354

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Ala Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  355
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  355

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Ala 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  356
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  356

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Leu Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  357
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  357

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Lys Met Phe Leu Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  358
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  358

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Leu Met Phe Met Gly Tyr Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  359
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  359

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Leu Met Phe Leu Gly Tyr Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  360
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  360

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Phe Met Phe Thr Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  361
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  361

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Met Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  362
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  362

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Tyr Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  363
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  363

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Asp Met Phe Leu Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  364
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  364

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Arg Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  365
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  365

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Leu Gly Trp Asn Cys Gly Asp Arg Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  366
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  366

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Lys Met Phe Leu Gly Trp Asn Cys Gly Thr Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  367
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  367

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Leu Gly Trp Asn Cys Gly Thr Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  368
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  368

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  369
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  369

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Met Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  370
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  370

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Trp Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  371
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  371

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Lys Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  372
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  372

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Leu Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  373
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  373

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Gln Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  374
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  374

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Pro Phe Pro Pro Glu Glu Glu Leu Gln Met Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  375
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  375

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Ala Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  376
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  376

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Tyr Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  377
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  377

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Tyr Phe Pro Asp Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  378
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  378

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Pro Phe Pro Pro Glu Glu Glu Leu Gln Ile Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  379
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  379

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Met Phe Pro Asp Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  380
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  380

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Leu Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Pro Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  381
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  381

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Ala Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Tyr Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  382
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  382

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Leu Ala Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  383
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  383

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Ala Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Met Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  384
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  384

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Lys Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Pro Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  385
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  385

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Val Ala Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  386
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  386

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Pro Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  387
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  387

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Lys Asp 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Tyr Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  388
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  388

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Leu His 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Pro Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  389
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  389

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Lys His 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Pro Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  390
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  390

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Asp 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  391
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  391

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Ser Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Ser Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  392
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  392

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Cys Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Cys Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  393
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  393

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Cys Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Cys Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  394
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  394

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Cys Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Cys Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  395
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  395

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Cys Leu Cys Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  396
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  396

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Cys Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Cys Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  397
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  397

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Cys Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Cys Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  398
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  398

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Cys Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Cys Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  399
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  399

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Cys Leu Cys Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  400
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  400

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Ala Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  401
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  401

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Ala Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  402
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  402

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Ala Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  403
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  403

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Ala Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  404
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  404

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ala Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  405
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  405

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Ala Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  406
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  406

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Ala Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  407
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  407

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Ala Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  408
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  408

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  409
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  409

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Ala Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  410
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  410

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Ala Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  411
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  411

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Ala Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  412
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  412

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Ala Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  413
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  413

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Ala Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  414
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  414

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Ala Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  415
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  415

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met Ala Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  416
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  416

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Ala Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  417
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  417

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Ile Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  418
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  418

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  419
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  419

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  420
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  420

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  421
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  421

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  422
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  422

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Phe Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asp Glu Val Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Ser Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Phe Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ala 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Val Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  423
<211>  991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  423

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg 
                405                 410                 415     


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
            420                 425                 430         


Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu 
        435                 440                 445             


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
    450                 455                 460                 


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
465                 470                 475                 480 


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
                485                 490                 495     


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
            500                 505                 510         


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
        515                 520                 525             


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
    530                 535                 540                 


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
545                 550                 555                 560 


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
                565                 570                 575     


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
            580                 585                 590         


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
        595                 600                 605             


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
    610                 615                 620                 


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
625                 630                 635                 640 


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
                645                 650                 655     


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
            660                 665                 670         


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
        675                 680                 685             


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
    690                 695                 700                 


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
705                 710                 715                 720 


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
                725                 730                 735     


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
            740                 745                 750         


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
        755                 760                 765             


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
    770                 775                 780                 


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
785                 790                 795                 800 


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
                805                 810                 815     


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
            820                 825                 830         


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
        835                 840                 845             


Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 
    850                 855                 860                 


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
865                 870                 875                 880 


Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 
                885                 890                 895     


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
            900                 905                 910         


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
        915                 920                 925             


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
    930                 935                 940                 


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
945                 950                 955                 960 


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
                965                 970                 975     


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985                 990     


<210>  424
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  424

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Tyr Met Phe Ser Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  425
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  425

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Tyr Met Phe Leu Gly Leu Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  426
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  426

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Tyr Met Phe Leu Gly Met Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  427
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  427

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Tyr Gly Met Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  428
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  428

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Tyr Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  429
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  429

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Tyr Met Phe Leu Gly Phe Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  430
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  430

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Tyr Met Phe Leu Gly Tyr Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  431
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  431

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Tyr Gly Leu Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  432
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  432

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Tyr Met Phe Met Gly Leu Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  433
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  433

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Asp Met Phe Phe Gly His Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  434
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  434

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Tyr Met Phe Asn Gly Phe Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  435
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  435

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Glu Tyr Met Tyr Leu Gly Tyr Ser Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  436
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  436

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Ala Tyr Met Trp Ser Gly Trp Asn Cys Gly Leu Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  437
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  437

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Tyr Met Met Trp Ser Gly Trp Asn Cys Gly Leu Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  438
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  438

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Ala Tyr Met Trp Ala Gly Trp Asn Cys Gly Leu Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  439
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  439

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Trp Trp Met Tyr Leu Gly Trp Ser Cys Gly Asn Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  440
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  440

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Glu Tyr Met Ala Gln Gly Tyr Ser Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  441
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  441

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Tyr Ile Met Trp Ser Gly Trp Asn Cys Gly Leu Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  442
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  442

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Trp Trp Met Phe Tyr Gly Trp Ser Cys Gly Asn Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  443
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  443

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Trp Trp Met Trp Leu Gly Trp Ser Cys Gly Asn Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  444
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  444

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Trp Trp Met Leu Tyr Gly Leu Ser Cys Gly Asn Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  445
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  445

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Trp Asp Met Arg Phe Gly Leu Ser Cys Gly Asn Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  446
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  446

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Trp Trp Met Phe Tyr Gly Leu Ser Cys Gly Asn Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  447
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  447

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Trp Trp Met Arg Phe Gly Leu Ser Cys Gly Asn Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  448
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  448

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Trp Asp Met Trp Tyr Gly Phe Ser Cys Gly Asn Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  449
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  449

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Glu Glu Trp 
    290                 295                 300                 


Leu Ala Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  450
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  450

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gln Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  451
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  451

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Glu Glu Trp 
    290                 295                 300                 


Leu Thr Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  452
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  452

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Lys Phe Pro Pro Glu Glu Glu Leu Gln Leu Glu Trp 
    290                 295                 300                 


Leu His Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  453
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  453

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Asn Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  454
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  454

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Lys Phe Pro Pro Glu Glu Glu Leu Gln Gln Glu Trp 
    290                 295                 300                 


Leu Asp Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  455
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  455

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Glu Glu Trp 
    290                 295                 300                 


Leu Asn Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  456
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  456

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Asn Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  457
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  457

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Phe Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  458
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  458

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Lys Phe Pro Pro Glu Glu Glu Leu Gln Leu Glu Trp 
    290                 295                 300                 


Leu Trp Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  459
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  459

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Lys Phe Pro Pro Glu Glu Glu Leu Gln Asp Glu Trp 
    290                 295                 300                 


Leu His Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  460
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  460

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Ile Lys Phe Pro Pro Glu Glu Glu Leu Gln Glu Glu Trp 
    290                 295                 300                 


Leu His Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  461
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  461

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Glu Thr 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  462
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  462

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Leu Thr 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  463
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  463

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Thr Glu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  464
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  464

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Thr Thr 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  465
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  465

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Arg Thr 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  466
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  466

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Leu Tyr 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  467
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  467

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Leu Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  468
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  468

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Asp Tyr 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  469
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  469

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Ala Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  470
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  470

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Ala Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  471
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  471

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Ala Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  472
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  472

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser Thr Pro 
    210                 215                 220                 


Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr Ser Tyr 
225                 230                 235                 240 


Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr Phe Pro 
                245                 250                 255     


Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys Gly Met 
            260                 265                 270         


Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Leu Glu 
        275                 280                 285             


Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg Glu Trp 
    290                 295                 300                 


Leu Ala Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val His Gln 
305                 310                 315                 320 


Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu Ala Asn 
                325                 330                 335     


Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser Gly Asp 
            340                 345                 350         


His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr Val Ser 
        355                 360                 365             


Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr Val Gly 
    370                 375                 380                 


Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser Gly Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp Ala His Lys Ser Glu 
                405                 410                 415     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            420                 425                 430         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
        435                 440                 445             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    450                 455                 460                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
465                 470                 475                 480 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                485                 490                 495     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            500                 505                 510         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        515                 520                 525             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    530                 535                 540                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                565                 570                 575     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            580                 585                 590         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        595                 600                 605             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    610                 615                 620                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
625                 630                 635                 640 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                645                 650                 655     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            660                 665                 670         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        675                 680                 685             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    690                 695                 700                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
705                 710                 715                 720 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                725                 730                 735     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            740                 745                 750         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        755                 760                 765             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    770                 775                 780                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
785                 790                 795                 800 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                805                 810                 815     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            820                 825                 830         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        835                 840                 845             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    850                 855                 860                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
865                 870                 875                 880 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                885                 890                 895     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            900                 905                 910         


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        915                 920                 925             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    930                 935                 940                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
945                 950                 955                 960 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                965                 970                 975     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            980                 985                 990         


Leu Gly Leu 
        995 


<210>  473
<211>  984
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  473

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Gly Arg Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala 
    210                 215                 220                 


Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys 
225                 230                 235                 240 


Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser 
                245                 250                 255     


Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe 
            260                 265                 270         


Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu 
        275                 280                 285             


Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu 
    290                 295                 300                 


Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr 
305                 310                 315                 320 


Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp 
                325                 330                 335     


Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly 
            340                 345                 350         


Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val 
        355                 360                 365             


Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu 
    370                 375                 380                 


Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp 
385                 390                 395                 400 


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
                405                 410                 415     


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
            420                 425                 430         


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
        435                 440                 445             


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
    450                 455                 460                 


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
465                 470                 475                 480 


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
                485                 490                 495     


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
            500                 505                 510         


Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 
        515                 520                 525             


Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
    530                 535                 540                 


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 
545                 550                 555                 560 


Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
                565                 570                 575     


Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 
            580                 585                 590         


Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 
        595                 600                 605             


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 
    610                 615                 620                 


Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 
625                 630                 635                 640 


His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
                645                 650                 655     


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 
            660                 665                 670         


Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 
        675                 680                 685             


Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 
    690                 695                 700                 


Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 
705                 710                 715                 720 


Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 
                725                 730                 735     


His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 
            740                 745                 750         


Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 
        755                 760                 765             


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
    770                 775                 780                 


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
785                 790                 795                 800 


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
                805                 810                 815     


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
            820                 825                 830         


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
        835                 840                 845             


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
    850                 855                 860                 


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
865                 870                 875                 880 


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
                885                 890                 895     


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
            900                 905                 910         


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
        915                 920                 925             


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
    930                 935                 940                 


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
945                 950                 955                 960 


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
                965                 970                 975     


Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 


<210>  474
<211>  984
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  474

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Gly His Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala 
    210                 215                 220                 


Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys 
225                 230                 235                 240 


Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser 
                245                 250                 255     


Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe 
            260                 265                 270         


Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu 
        275                 280                 285             


Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu 
    290                 295                 300                 


Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr 
305                 310                 315                 320 


Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp 
                325                 330                 335     


Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly 
            340                 345                 350         


Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val 
        355                 360                 365             


Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu 
    370                 375                 380                 


Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Asp 
385                 390                 395                 400 


Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
                405                 410                 415     


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
            420                 425                 430         


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
        435                 440                 445             


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
    450                 455                 460                 


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
465                 470                 475                 480 


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
                485                 490                 495     


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
            500                 505                 510         


Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 
        515                 520                 525             


Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
    530                 535                 540                 


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 
545                 550                 555                 560 


Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
                565                 570                 575     


Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 
            580                 585                 590         


Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 
        595                 600                 605             


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 
    610                 615                 620                 


Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 
625                 630                 635                 640 


His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
                645                 650                 655     


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 
            660                 665                 670         


Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 
        675                 680                 685             


Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 
    690                 695                 700                 


Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 
705                 710                 715                 720 


Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 
                725                 730                 735     


His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 
            740                 745                 750         


Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 
        755                 760                 765             


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
    770                 775                 780                 


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
785                 790                 795                 800 


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
                805                 810                 815     


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
            820                 825                 830         


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
        835                 840                 845             


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
    850                 855                 860                 


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
865                 870                 875                 880 


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
                885                 890                 895     


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
            900                 905                 910         


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
        915                 920                 925             


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
    930                 935                 940                 


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
945                 950                 955                 960 


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
                965                 970                 975     


Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 


<210>  475
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  475

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Gly Pro Ser Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu 
    210                 215                 220                 


Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn 
225                 230                 235                 240 


Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr 
                245                 250                 255     


Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys 
            260                 265                 270         


Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu 
        275                 280                 285             


Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe 
    290                 295                 300                 


Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn 
305                 310                 315                 320 


Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His 
                325                 330                 335     


Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro 
            340                 345                 350         


Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr 
        355                 360                 365             


Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His 
    370                 375                 380                 


Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
                405                 410                 415     


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            420                 425                 430         


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        435                 440                 445             


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    450                 455                 460                 


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
465                 470                 475                 480 


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                485                 490                 495     


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            500                 505                 510         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        515                 520                 525             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    530                 535                 540                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
545                 550                 555                 560 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                565                 570                 575     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            580                 585                 590         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        595                 600                 605             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    610                 615                 620                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
625                 630                 635                 640 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                645                 650                 655     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            660                 665                 670         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        675                 680                 685             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    690                 695                 700                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
705                 710                 715                 720 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                725                 730                 735     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            740                 745                 750         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        755                 760                 765             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    770                 775                 780                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
785                 790                 795                 800 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                805                 810                 815     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            820                 825                 830         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        835                 840                 845             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    850                 855                 860                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
865                 870                 875                 880 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                885                 890                 895     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            900                 905                 910         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        915                 920                 925             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    930                 935                 940                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
945                 950                 955                 960 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                965                 970                 975     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985 


<210>  476
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  476

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Gly Glu Asp Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu 
    210                 215                 220                 


Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn 
225                 230                 235                 240 


Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr 
                245                 250                 255     


Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys 
            260                 265                 270         


Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu 
        275                 280                 285             


Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe 
    290                 295                 300                 


Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn 
305                 310                 315                 320 


Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His 
                325                 330                 335     


Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro 
            340                 345                 350         


Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr 
        355                 360                 365             


Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His 
    370                 375                 380                 


Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
                405                 410                 415     


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            420                 425                 430         


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        435                 440                 445             


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    450                 455                 460                 


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
465                 470                 475                 480 


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                485                 490                 495     


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            500                 505                 510         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        515                 520                 525             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    530                 535                 540                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
545                 550                 555                 560 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                565                 570                 575     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            580                 585                 590         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        595                 600                 605             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    610                 615                 620                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
625                 630                 635                 640 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                645                 650                 655     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            660                 665                 670         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        675                 680                 685             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    690                 695                 700                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
705                 710                 715                 720 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                725                 730                 735     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            740                 745                 750         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        755                 760                 765             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    770                 775                 780                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
785                 790                 795                 800 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                805                 810                 815     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            820                 825                 830         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        835                 840                 845             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    850                 855                 860                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
865                 870                 875                 880 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                885                 890                 895     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            900                 905                 910         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        915                 920                 925             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    930                 935                 940                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
945                 950                 955                 960 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                965                 970                 975     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985 


<210>  477
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  477

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Gly Asp Asp Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu 
    210                 215                 220                 


Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn 
225                 230                 235                 240 


Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr 
                245                 250                 255     


Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys 
            260                 265                 270         


Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu 
        275                 280                 285             


Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe 
    290                 295                 300                 


Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn 
305                 310                 315                 320 


Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His 
                325                 330                 335     


Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro 
            340                 345                 350         


Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr 
        355                 360                 365             


Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His 
    370                 375                 380                 


Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
                405                 410                 415     


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            420                 425                 430         


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        435                 440                 445             


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    450                 455                 460                 


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
465                 470                 475                 480 


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                485                 490                 495     


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            500                 505                 510         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        515                 520                 525             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    530                 535                 540                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
545                 550                 555                 560 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                565                 570                 575     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            580                 585                 590         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        595                 600                 605             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    610                 615                 620                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
625                 630                 635                 640 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                645                 650                 655     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            660                 665                 670         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        675                 680                 685             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    690                 695                 700                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
705                 710                 715                 720 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                725                 730                 735     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            740                 745                 750         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        755                 760                 765             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    770                 775                 780                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
785                 790                 795                 800 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                805                 810                 815     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            820                 825                 830         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        835                 840                 845             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    850                 855                 860                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
865                 870                 875                 880 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                885                 890                 895     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            900                 905                 910         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        915                 920                 925             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    930                 935                 940                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
945                 950                 955                 960 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                965                 970                 975     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985 


<210>  478
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  478

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Asn Trp Gly Gly Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys 
    210                 215                 220                 


Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp 
225                 230                 235                 240 


Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp 
                245                 250                 255     


Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn 
            260                 265                 270         


Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu 
        275                 280                 285             


Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln 
    290                 295                 300                 


Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu 
305                 310                 315                 320 


Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn 
                325                 330                 335     


His Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu 
            340                 345                 350         


Pro Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu 
        355                 360                 365             


Thr Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe 
    370                 375                 380                 


His Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
                405                 410                 415     


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
            420                 425                 430         


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
        435                 440                 445             


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
    450                 455                 460                 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
465                 470                 475                 480 


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
                485                 490                 495     


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
            500                 505                 510         


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
        515                 520                 525             


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
    530                 535                 540                 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
545                 550                 555                 560 


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
                565                 570                 575     


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
            580                 585                 590         


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
        595                 600                 605             


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
    610                 615                 620                 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
625                 630                 635                 640 


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
                645                 650                 655     


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
            660                 665                 670         


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
        675                 680                 685             


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
    690                 695                 700                 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
705                 710                 715                 720 


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
                725                 730                 735     


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
            740                 745                 750         


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
        755                 760                 765             


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
    770                 775                 780                 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
785                 790                 795                 800 


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
                805                 810                 815     


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
            820                 825                 830         


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
        835                 840                 845             


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
    850                 855                 860                 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
865                 870                 875                 880 


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
                885                 890                 895     


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
            900                 905                 910         


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
        915                 920                 925             


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
    930                 935                 940                 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
945                 950                 955                 960 


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
                965                 970                 975     


Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985     


<210>  479
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  479

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ala Glu Asp Asn Asp Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln 
    210                 215                 220                 


Lys Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly 
225                 230                 235                 240 


Trp Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser 
                245                 250                 255     


Trp Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr 
            260                 265                 270         


Asn Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro 
        275                 280                 285             


Glu Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile 
    290                 295                 300                 


Gln Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile 
                325                 330                 335     


Asn His Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu 
            340                 345                 350         


Leu Pro Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro 
        355                 360                 365             


Glu Thr Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn 
    370                 375                 380                 


Phe His Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
385                 390                 395                 400 


Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu 
                405                 410                 415     


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
            420                 425                 430         


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
        435                 440                 445             


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
    450                 455                 460                 


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
465                 470                 475                 480 


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
                485                 490                 495     


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
            500                 505                 510         


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
        515                 520                 525             


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
    530                 535                 540                 


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
545                 550                 555                 560 


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
                565                 570                 575     


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
            580                 585                 590         


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
        595                 600                 605             


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
    610                 615                 620                 


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
625                 630                 635                 640 


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
                645                 650                 655     


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
            660                 665                 670         


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
        675                 680                 685             


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
    690                 695                 700                 


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
705                 710                 715                 720 


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
                725                 730                 735     


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
            740                 745                 750         


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
        755                 760                 765             


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
    770                 775                 780                 


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
785                 790                 795                 800 


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
                805                 810                 815     


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
            820                 825                 830         


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
        835                 840                 845             


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
    850                 855                 860                 


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
865                 870                 875                 880 


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
                885                 890                 895     


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
            900                 905                 910         


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
        915                 920                 925             


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
    930                 935                 940                 


Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 
945                 950                 955                 960 


Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 
                965                 970                 975     


Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985         


<210>  480
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  480

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Asp Lys Asn Asp Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln 
    210                 215                 220                 


Lys Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly 
225                 230                 235                 240 


Trp Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser 
                245                 250                 255     


Trp Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr 
            260                 265                 270         


Asn Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro 
        275                 280                 285             


Glu Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile 
    290                 295                 300                 


Gln Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile 
                325                 330                 335     


Asn His Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu 
            340                 345                 350         


Leu Pro Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro 
        355                 360                 365             


Glu Thr Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn 
    370                 375                 380                 


Phe His Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
385                 390                 395                 400 


Ser Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu 
                405                 410                 415     


Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 
            420                 425                 430         


Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 
        435                 440                 445             


Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 
    450                 455                 460                 


Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 
465                 470                 475                 480 


Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 
                485                 490                 495     


Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 
            500                 505                 510         


Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 
        515                 520                 525             


Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 
    530                 535                 540                 


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
545                 550                 555                 560 


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
                565                 570                 575     


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
            580                 585                 590         


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
        595                 600                 605             


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
    610                 615                 620                 


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
625                 630                 635                 640 


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
                645                 650                 655     


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
            660                 665                 670         


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
        675                 680                 685             


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
    690                 695                 700                 


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
705                 710                 715                 720 


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
                725                 730                 735     


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
            740                 745                 750         


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
        755                 760                 765             


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
    770                 775                 780                 


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
785                 790                 795                 800 


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
                805                 810                 815     


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
            820                 825                 830         


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
        835                 840                 845             


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
    850                 855                 860                 


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
865                 870                 875                 880 


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
                885                 890                 895     


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
            900                 905                 910         


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
        915                 920                 925             


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
    930                 935                 940                 


Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 
945                 950                 955                 960 


Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 
                965                 970                 975     


Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985         


<210>  481
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  481

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Ser Thr Ser Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys 
    210                 215                 220                 


Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp 
225                 230                 235                 240 


Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp 
                245                 250                 255     


Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn 
            260                 265                 270         


Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu 
        275                 280                 285             


Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln 
    290                 295                 300                 


Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu 
305                 310                 315                 320 


Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn 
                325                 330                 335     


His Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu 
            340                 345                 350         


Pro Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu 
        355                 360                 365             


Thr Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe 
    370                 375                 380                 


His Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
                405                 410                 415     


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
            420                 425                 430         


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
        435                 440                 445             


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
    450                 455                 460                 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
465                 470                 475                 480 


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
                485                 490                 495     


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
            500                 505                 510         


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
        515                 520                 525             


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
    530                 535                 540                 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
545                 550                 555                 560 


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
                565                 570                 575     


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
            580                 585                 590         


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
        595                 600                 605             


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
    610                 615                 620                 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
625                 630                 635                 640 


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
                645                 650                 655     


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
            660                 665                 670         


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
        675                 680                 685             


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
    690                 695                 700                 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
705                 710                 715                 720 


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
                725                 730                 735     


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
            740                 745                 750         


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
        755                 760                 765             


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
    770                 775                 780                 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
785                 790                 795                 800 


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
                805                 810                 815     


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
            820                 825                 830         


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
        835                 840                 845             


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
    850                 855                 860                 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
865                 870                 875                 880 


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
                885                 890                 895     


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
            900                 905                 910         


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
        915                 920                 925             


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
    930                 935                 940                 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
945                 950                 955                 960 


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
                965                 970                 975     


Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985     


<210>  482
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  482

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Asp Gly Asp Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys 
    210                 215                 220                 


Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp 
225                 230                 235                 240 


Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp 
                245                 250                 255     


Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn 
            260                 265                 270         


Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu 
        275                 280                 285             


Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln 
    290                 295                 300                 


Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu 
305                 310                 315                 320 


Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn 
                325                 330                 335     


His Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu 
            340                 345                 350         


Pro Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu 
        355                 360                 365             


Thr Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe 
    370                 375                 380                 


His Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
                405                 410                 415     


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
            420                 425                 430         


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
        435                 440                 445             


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
    450                 455                 460                 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
465                 470                 475                 480 


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
                485                 490                 495     


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
            500                 505                 510         


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
        515                 520                 525             


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
    530                 535                 540                 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
545                 550                 555                 560 


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
                565                 570                 575     


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
            580                 585                 590         


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
        595                 600                 605             


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
    610                 615                 620                 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
625                 630                 635                 640 


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
                645                 650                 655     


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
            660                 665                 670         


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
        675                 680                 685             


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
    690                 695                 700                 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
705                 710                 715                 720 


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
                725                 730                 735     


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
            740                 745                 750         


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
        755                 760                 765             


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
    770                 775                 780                 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
785                 790                 795                 800 


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
                805                 810                 815     


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
            820                 825                 830         


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
        835                 840                 845             


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
    850                 855                 860                 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
865                 870                 875                 880 


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
                885                 890                 895     


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
            900                 905                 910         


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
        915                 920                 925             


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
    930                 935                 940                 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
945                 950                 955                 960 


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
                965                 970                 975     


Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985     


<210>  483
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  483

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Glu Thr Gly Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys 
    210                 215                 220                 


Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp 
225                 230                 235                 240 


Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp 
                245                 250                 255     


Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn 
            260                 265                 270         


Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu 
        275                 280                 285             


Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln 
    290                 295                 300                 


Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu 
305                 310                 315                 320 


Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn 
                325                 330                 335     


His Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu 
            340                 345                 350         


Pro Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu 
        355                 360                 365             


Thr Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe 
    370                 375                 380                 


His Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
                405                 410                 415     


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
            420                 425                 430         


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
        435                 440                 445             


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
    450                 455                 460                 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
465                 470                 475                 480 


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
                485                 490                 495     


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
            500                 505                 510         


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
        515                 520                 525             


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
    530                 535                 540                 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
545                 550                 555                 560 


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
                565                 570                 575     


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
            580                 585                 590         


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
        595                 600                 605             


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
    610                 615                 620                 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
625                 630                 635                 640 


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
                645                 650                 655     


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
            660                 665                 670         


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
        675                 680                 685             


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
    690                 695                 700                 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
705                 710                 715                 720 


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
                725                 730                 735     


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
            740                 745                 750         


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
        755                 760                 765             


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
    770                 775                 780                 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
785                 790                 795                 800 


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
                805                 810                 815     


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
            820                 825                 830         


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
        835                 840                 845             


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
    850                 855                 860                 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
865                 870                 875                 880 


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
                885                 890                 895     


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
            900                 905                 910         


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
        915                 920                 925             


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
    930                 935                 940                 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
945                 950                 955                 960 


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
                965                 970                 975     


Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985     


<210>  484
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  484

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Asp Ser Gly Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys 
    210                 215                 220                 


Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp 
225                 230                 235                 240 


Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp 
                245                 250                 255     


Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn 
            260                 265                 270         


Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu 
        275                 280                 285             


Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln 
    290                 295                 300                 


Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu 
305                 310                 315                 320 


Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn 
                325                 330                 335     


His Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu 
            340                 345                 350         


Pro Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu 
        355                 360                 365             


Thr Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe 
    370                 375                 380                 


His Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
                405                 410                 415     


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
            420                 425                 430         


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
        435                 440                 445             


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
    450                 455                 460                 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
465                 470                 475                 480 


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
                485                 490                 495     


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
            500                 505                 510         


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
        515                 520                 525             


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
    530                 535                 540                 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
545                 550                 555                 560 


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
                565                 570                 575     


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
            580                 585                 590         


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
        595                 600                 605             


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
    610                 615                 620                 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
625                 630                 635                 640 


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
                645                 650                 655     


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
            660                 665                 670         


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
        675                 680                 685             


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
    690                 695                 700                 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
705                 710                 715                 720 


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
                725                 730                 735     


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
            740                 745                 750         


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
        755                 760                 765             


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
    770                 775                 780                 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
785                 790                 795                 800 


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
                805                 810                 815     


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
            820                 825                 830         


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
        835                 840                 845             


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
    850                 855                 860                 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
865                 870                 875                 880 


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
                885                 890                 895     


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
            900                 905                 910         


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
        915                 920                 925             


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
    930                 935                 940                 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
945                 950                 955                 960 


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
                965                 970                 975     


Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985     


<210>  485
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCPN1 variant

<400>  485

Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val Arg Thr Leu Tyr 
1               5                   10                  15      


Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val Tyr Ser Ile Gly 
            20                  25                  30          


Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu Phe Ser Asp His 
        35                  40                  45              


Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys Tyr Val Gly Asn 
    50                  55                  60                  


Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met Leu Gln Leu Ser 
65                  70                  75                  80  


Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln Arg Ile Val Gln 
                85                  90                  95      


Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser Met Asn Pro Asp 
            100                 105                 110         


Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys Pro Gly Tyr Leu 
        115                 120                 125             


Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn Arg Asn Phe Pro 
    130                 135                 140                 


Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr Gly Gly Pro Asn 
145                 150                 155                 160 


His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln Val Glu Pro Glu 
                165                 170                 175     


Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val Leu Ser 
            180                 185                 190         


Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr Asp Lys 
        195                 200                 205             


Ser Glu Asp Ser Glu Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys 
    210                 215                 220                 


Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp 
225                 230                 235                 240 


Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp 
                245                 250                 255     


Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn 
            260                 265                 270         


Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu 
        275                 280                 285             


Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln 
    290                 295                 300                 


Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu 
305                 310                 315                 320 


Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn 
                325                 330                 335     


His Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu 
            340                 345                 350         


Pro Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu 
        355                 360                 365             


Thr Val Thr Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe 
    370                 375                 380                 


His Leu Lys Arg Ser Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 
                405                 410                 415     


Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 
            420                 425                 430         


Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 
        435                 440                 445             


Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 
    450                 455                 460                 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 
465                 470                 475                 480 


Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 
                485                 490                 495     


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 
            500                 505                 510         


Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 
        515                 520                 525             


His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 
    530                 535                 540                 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 
545                 550                 555                 560 


Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 
                565                 570                 575     


Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 
            580                 585                 590         


Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 
        595                 600                 605             


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 
    610                 615                 620                 


Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 
625                 630                 635                 640 


Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
                645                 650                 655     


Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 
            660                 665                 670         


Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 
        675                 680                 685             


His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 
    690                 695                 700                 


Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 
705                 710                 715                 720 


Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 
                725                 730                 735     


Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 
            740                 745                 750         


Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 
        755                 760                 765             


Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 
    770                 775                 780                 


Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 
785                 790                 795                 800 


Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 
                805                 810                 815     


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 
            820                 825                 830         


Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 
        835                 840                 845             


Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 
    850                 855                 860                 


His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 
865                 870                 875                 880 


Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 
                885                 890                 895     


Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 
            900                 905                 910         


Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 
        915                 920                 925             


Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 
    930                 935                 940                 


Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 
945                 950                 955                 960 


Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 
                965                 970                 975     


Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            980                 985     


<210>  486
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  486

Ala Ala Thr Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val 
1               5                   10                  15      


Ala Thr Arg Val His Ser 
            20          


<210>  487
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  487

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  488
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  488

Thr Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr 
1               5                   10                  15      


Arg Val His Ser 
            20  


<210>  489
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  489

Thr Thr Thr Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val 
1               5                   10                  15      


Ala Thr Arg Val His Ser 
            20          


<210>  490
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  490

Gly Ser Ala Thr Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
1               5                   10                  15      


Leu Trp Val Pro Gly Ser Thr Gly 
            20                  


