                         SEQUENCE LISTING

<110>  TALEM THERAPEUTICS LLC
 
<120>  ANTI-SPIKE GLYCOPROTEIN ANTIBODIES AND THE THERAPEUTIC USE 
       THEREOF

<130>  TALM-001/00WO 346734-2002

<150>  US 63/142,787
<151>  2021-01-28

<160>  215   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Arg Leu Gly Asp Tyr Ser Gly Met Asp Val 
1               5                   10      


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Ser Asn Ile Gly Ser Asn Pro 
1               5               


<210>  5
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  6
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Tyr Thr Phe Thr Ser Tyr Tyr Ser Glu Gln Ile Asp 
1               5                   10              


<210>  7
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Asp Pro Ser Gly Gly Ser Thr 
1               5               


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Arg Ser Arg Asp Gly Tyr Ile Asp Asp Ala Phe Asp Ile 
1               5                   10                  


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Ser Asn Ile Gly Asn Asn Tyr 
1               5               


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 
1               5                   10      


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  12

Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  13
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Arg Asp Lys Leu Pro Phe Ser Val Gly Ala Thr His Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Ser Asn Ile Gly Asn Asn Ala 
1               5               


<210>  15
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Ser Trp Asp Asp Arg Leu Asp Ser Pro Val 
1               5                   10      


<210>  16
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Asp Pro Ser Gly Gly Thr Thr 
1               5               


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Arg Gly Gly Phe Ala Asp Ala Val Asp Tyr 
1               5                   10      


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Gly Ser Ile Ala Ser Asn Tyr 
1               5               


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Ser Tyr Asp Ser Gly Asn Val Ile 
1               5                   


<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Tyr Thr Phe Thr Ser Tyr Ala 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  21

Ile Asn Ala Gly Asn Gly Asn Thr 
1               5               


<210>  22
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Arg Glu Gly Met Ile Thr Phe Gly Gly Val Ile Val Thr Asn Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  23
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  23

Asn Ile Gly Ser Glu Ser 
1               5       


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ala Trp Asp Gly Ser Thr Val Val 
1               5                   


<210>  25
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  26

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  27
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Lys Glu Gly Glu Leu Arg Gly Ala Phe Asp Ile 
1               5                   10          


<210>  28
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Leu Leu His Ser Ile Gly Tyr Asn Phe 
1               5                   10      


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gln Ala Leu Gln Arg Thr Leu Tyr Thr 
1               5                   10  


<210>  30
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  30

Ile Asp Pro Thr Gly Gly Ser Thr 
1               5               


<210>  31
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Ser Ala Gly Val Gly Asn Thr Phe Asp Tyr 
1               5                   10      


<210>  32
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Gly Ser Ile Ala Arg Asn Tyr 
1               5               


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Gln Ser Tyr Asp Ser Ser Asn Gln Trp Val 
1               5                   10  


<210>  34
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Arg Asn Pro Ser Leu Tyr Ser Ser Pro Thr Asp Tyr 
1               5                   10              


<210>  35
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Ser Asn Ile Gly Ser Asn Thr 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Tyr Thr Phe Ser Thr Tyr Tyr 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  37

Ser Gly Ser Ile Ala Gly Asn Tyr 
1               5               


<210>  38
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Ser Tyr Asp Ala Ser His Leu His Val Ile 
1               5                   10      


<210>  39
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Gly Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  40

Ile Ile Pro Ile Leu Asp Thr Thr 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  41

Val Arg Glu Glu Gly Phe Asp Tyr 
1               5               


<210>  42
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Gly Ile Asn Val Gly Ala Tyr Asn 
1               5                   


<210>  43
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  43

Tyr Asn Ser Asp Ser Asp Asn 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ile Trp Arg Ser Ser Ala Trp Val 
1               5                   


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Phe Thr Phe Asp Thr Tyr Gly 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  46

Ile Ser Asn Asp Gly Ser Lys Lys 
1               5               


<210>  47
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Arg Val Thr Glu Pro Tyr Met Val Thr Pro Leu Met Leu Phe Arg 
1               5                   10                  15      


Met Ala Ile Asp Asn 
            20      


<210>  48
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  48

Asn Phe Gly Thr Lys Ser 
1               5       


<210>  49
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Val Trp Asp Ser Ser Ala Asp Leu Arg Gly Val Val 
1               5                   10              


<210>  50
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  51

Ile Ser Arg Ser Gly Gly Ser Thr 
1               5               


<210>  52
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  52

Ala Ala Ser Asn Glu Gly Gly Thr Trp Tyr Gly Ser Ser Trp Tyr Arg 
1               5                   10                  15      


Pro Ser Ser Tyr Glu His 
            20          


<210>  53
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Ala Ser Asn Glu Gly Gly Thr Trp Tyr Gly Ser Ser Trp Tyr Arg 
1               5                   10                  15      


Pro Ser Ser Tyr Glu Tyr 
            20          


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Tyr Ile Phe Thr Asn Tyr Asp 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  55

Val Asn Pro Asn Ser Gly Lys Val 
1               5               


<210>  56
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Arg Gly His Thr Asp Phe 
1               5           


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Gly Thr Phe Asn Thr Tyr Ser 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  58

Ile Ile Pro Ile Phe Asp Lys Pro 
1               5               


<210>  59
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Arg Gly Thr Gly Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  60
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  60

Arg Ser Asn Ile Gly Asn Tyr Pro 
1               5               


<210>  61
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  61

Ala Thr Trp Asp Asp Ser Leu Asn Val Trp Val 
1               5                   10      


<210>  62
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  62

Ala Arg Tyr Leu Ser Ser Glu Gly Met Asp 
1               5                   10  


<210>  63
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  63

Ala Ser Trp Asp Asp Ser Leu Asn Glu Gly Val 
1               5                   10      


<210>  64
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  65

Ile Ile Pro Ile Phe Gly Thr Thr 
1               5               


<210>  66
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  66

Ala Arg Asp His Gly Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  67
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  67

Asp Ser Asn Ile Gly Gln Asn Gly 
1               5               


<210>  68
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Ser Trp Asp Asp Ser Leu Ser Ala Trp Val 
1               5                   10      


<210>  69
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  69

Ile Ile Pro Met Phe Asn Ser Ala 
1               5               


<210>  70
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  70

Ala Arg Glu Ser Ser Gly Tyr Tyr Tyr Val Ser Asn Trp Phe Asp Pro 
1               5                   10                  15      


<210>  71
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  71

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  72
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  73
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  73

Ala Arg Gly Ser His Tyr Gly Asp Tyr Asp Tyr 
1               5                   10      


<210>  74
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  74

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  75
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  75

Thr Tyr Tyr Arg Ser Lys Trp 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Arg Thr Ile Gly Trp Tyr Asp Ser 
1               5                   


<210>  77
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  77

Ala Leu Pro Lys Gln Phe 
1               5       


<210>  78
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Ser Ala Asp Ser Ser Ala Thr Tyr Glu Val 
1               5                   10      


<210>  79
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Arg Arg Gln Ser Gly Ser Gly Tyr Asp Tyr 
1               5                   10      


<210>  80
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  80

Ser Ser Asn Val Gly Ser Asn Ser 
1               5               


<210>  81
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  81

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  82
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  82

Ala Arg Trp Ser Glu Gly Asn Gly Phe Asp Tyr 
1               5                   10      


<210>  83
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  83

Ser Ser Asn Ile Gly Ser Asn Ser 
1               5               


<210>  84
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  84

Leu Ala Val Ala Gly Thr Gly Gly Asp Ala Phe Asp Ile 
1               5                   10              


<210>  85
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  85

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  86
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  86

Gln Gln Gly His Ser Phe Pro Leu Thr 
1               5                   


<210>  87
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  87

Asn Ile Glu Ser Lys Tyr 
1               5       


<210>  88
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Val Trp Asp Arg Thr Ser Gly His Phe Val 
1               5                   10      


<210>  89
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  89

Gly Phe Ser Phe Thr Asn Tyr Gly 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  90

Ile Ser Tyr Asp Gly Ser Ile Lys 
1               5               


<210>  91
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  91

Thr Arg Glu Arg Gly Thr Gly Ile Asp Tyr 
1               5                   10  


<210>  92
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  92

Lys Ser Asp Ile Gly Ala Tyr Asn Tyr 
1               5                   


<210>  93
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  93

Ser Ser Tyr Thr Thr Ser Gly Thr Val Val 
1               5                   10  


<210>  94
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  94

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  95

Ile Ser Tyr Asp Gly Ser Ile Glu 
1               5               


<210>  96
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  96

Ala Arg Asp Glu Asp Gly Ala Phe Asp Ile 
1               5                   10  


<210>  97
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  97

Glu Ser Val Ser Tyr Ser Ser Ser Asn Lys Asn Tyr 
1               5                   10          


<210>  98
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  98

Gln Gln Tyr Tyr Ser Ser Pro Leu Thr 
1               5                   


<210>  99
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Phe Thr Phe Ser Asp Tyr Pro 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  100

Ile Ser Tyr Asp Gly Trp Thr Lys 
1               5               


<210>  101
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  101

Val Arg Gly Thr Asp Tyr Gly Asp Ser 
1               5                   


<210>  102
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  102

Gly Thr Trp Asp Asn Ser Leu Ser Ala Trp Val 
1               5                   10      


<210>  103
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  103

Gly Phe Thr Phe Asn Asn Tyr Pro 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  104

Ile Ser Tyr Asp Gly Asn His Lys 
1               5               


<210>  105
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  105

Ala Ser Asp Leu Ser Gly Ala Glu Asp Ser 
1               5                   10  


<210>  106
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  106

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  107
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  107

Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 
1               5                   10  


<210>  108
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  108

Gly Phe Thr Leu Ser Asp Tyr Pro 
1               5               


<210>  109
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ser Tyr Asp Gly Ser Leu Lys 
1               5               


<210>  110
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  110

Ala Arg Gly Asn Ser Asp Gly Asp Phe Asp Tyr 
1               5                   10      


<210>  111
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  111

Asp Ile Gly Ser Arg Ser 
1               5       


<210>  112
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  112

Gln Ala Trp Asp Ser Ser Thr Val Val 
1               5                   


<210>  113
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  113

Gly Phe Ser Phe Asn Thr Phe Pro 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  114

Ile Ser Tyr Asp Gly Ser Phe Lys 
1               5               


<210>  115
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  115

Ala Ser Pro Gly Asp Ser Asp Trp Ala Asp Phe Glu Asn 
1               5                   10              


<210>  116
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  116

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  117
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  117

Gly Phe Asn Phe Ser Leu Tyr Gly 
1               5               


<210>  118
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  118

Ile Ser Tyr Asp Gly Ser Gln Lys 
1               5               


<210>  119
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  119

Val Lys Gly Glu Gly Ser Leu Asp Tyr 
1               5                   


<210>  120
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  120

Thr Ser Asp Val Gly Gly Tyr Gly Tyr 
1               5                   


<210>  121
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  121

Val Ser Tyr Thr Leu Ser Ser Leu Val Val 
1               5                   10  


<210>  122
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  122

Gly Ser Ile Pro Ser Val Asn Val 
1               5               


<210>  123
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  123

Val Thr Ser Asp Gly Arg Thr 
1               5           


<210>  124
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  124

Leu Ile Thr Asn Gln Asp His Asn Thr Leu Gly Val 
1               5                   10          


<210>  125
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  125

Gly Phe Ser Leu Asn Thr Arg Gly Met Ser 
1               5                   10  


<210>  126
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  126

Ile Asp Trp Glu Asp Asp Lys 
1               5           


<210>  127
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  127

Ala Arg Thr Tyr Ser Val Gly Val Lys Tyr Phe Gly Met Asp Val 
1               5                   10                  15  


<210>  128
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  128

Gly Asn Val Thr Ser Ile Thr Leu 
1               5               


<210>  129
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  129

Ile Ile Asn Asp Asp Asp Arg Thr 
1               5               


<210>  130
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  130

Ser Ala Lys Ala Gly Gly Asn Phe Tyr 
1               5                   


<210>  131
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  131

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Lys 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Asp Tyr Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  132
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  132

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Ser Gly Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  133
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  133

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Asp Gly Tyr Ile Asp Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  134
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  134

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  135
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  135

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Lys Leu Pro Phe Ser Val Gly Ala Thr His Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  136
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  136

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asn Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Ala Ser Thr Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Asp Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Arg Leu 
                85                  90                  95      


Asp Ser Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  137
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  137

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Val Lys Val Ser Cys Lys Ala 
            20                  25                  30          


Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala 
        35                  40                  45              


Pro Gly Gln Gly Pro Glu Trp Met Gly Val Ile Asp Pro Ser Gly Gly 
    50                  55                  60                  


Thr Thr Ser Tyr Ala Gln Lys Phe His Asp Arg Ile Ala Met Thr Arg 
65                  70                  75                  80  


Asp Thr Ser Thr Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser 
                85                  90                  95      


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Phe Ala Asp Ala 
            100                 105                 110         


Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  138
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  138

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Gly Asn Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  139
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  139

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Met Ile Thr Phe Gly Gly Val Ile Val Thr Asn Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  140
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  140

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Glu Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Ser Cys Gln Ala Trp Asp Gly Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  141
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  141

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Glu Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  142
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  142

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Thr Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Ile Gly Tyr Asn Phe Val Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Ser Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Arg Thr Leu Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ser 
            100                 105                 110         


Lys 
    


<210>  143
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  143

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Thr Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Gly Val Gly Asn Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  144
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  144

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Arg Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Arg Ser Pro Asn Ile Leu 
        35                  40                  45              


Ile Phe Glu Asp Lys Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Gln Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  145
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  145

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Pro Ser Leu Tyr Ser Ser Pro Thr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  146
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  146

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  147
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  147

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Leu Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Thr Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asp Pro Ser Gly Gly Thr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Asp Arg Ile Ala Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Ala Asp Ala Val Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  148
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  148

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Asn Ser Gly Ser Ile Ala Gly Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ala 
                85                  90                  95      


Ser His Leu His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  149
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  149

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Leu Asp Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  150
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  150

Gln Ser Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Asn Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Phe 
        35                  40                  45              


Val Leu Arg Tyr Asn Ser Asp Ser Asp Asn Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp Arg Ser Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  151
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  151

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Pro Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Asn Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Val Thr Glu Pro Tyr Met Val Thr Pro Leu Met Leu Phe Arg 
            100                 105                 110         


Met Ala Ile Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  152
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  152

Ser Tyr Val Leu Thr Gln Pro Pro Ser Met Ser Val Ala Pro Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Gly Asn Phe Gly Thr Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Ser Gly Arg Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Ala Asn Asp Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Ser Ala Asp Leu 
                85                  90                  95      


Arg Gly Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  153
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  153

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Val Leu Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Val Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Gly Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Asn Glu Gly Gly Thr Trp Tyr Gly Ser Ser Trp Tyr Arg 
            100                 105                 110         


Pro Ser Ser Tyr Glu His Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  154
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  154

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Val Leu Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Gly Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Asn Glu Gly Gly Thr Trp Tyr Gly Ser Ser Trp Tyr Arg 
            100                 105                 110         


Pro Ser Ser Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  155
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  155

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Thr Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Val Asn Pro Asn Ser Gly Lys Val Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ile Met Thr Arg Ser Asp Ser Glu Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Asn Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Thr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  156
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  156

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Arg Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  157
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  157

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Asn Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Ile Pro Ile Phe Asp Lys Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Gly Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  158
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  158

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Arg Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Phe Gly Ser Arg Ser Asn Ile Gly Asn Tyr 
            20                  25                  30          


Pro Val Asn Trp Tyr His Gln Val Pro Gly Lys Ala Pro Lys Val Val 
        35                  40                  45              


Val Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Tyr Lys Ser Gly Thr Ser Ala Ser Leu Thr Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  159
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  159

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Leu Ser Ser Glu Gly Met Asp Val Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  160
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  160

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Asn Ile Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Val Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Glu Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  161
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  161

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Gly Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  162
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  162

Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Leu Ser Cys Ser Gly Gly Asp Ser Asn Ile Gly Gln Asn 
            20                  25                  30          


Gly Val Asn Trp Tyr Leu His Val Pro Gly Lys Ala Pro Arg Leu Val 
        35                  40                  45              


Val Tyr Tyr Asp Tyr Leu Val Ser Ala Gly Met Ser Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Gly Val Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  163
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  163

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Asn Ser Ala Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Ile Thr Ala Asp Lys Ala Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Ser Gly Tyr Tyr Tyr Val Ser Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  164
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  164

Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Ile Pro Gly Thr Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Ser Gly Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  165
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  165

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Tyr Gly Asp Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  166
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  166

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  167
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  167

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Asn Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Thr Ile Gly Trp Tyr Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  168
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  168

Ser Tyr Glu Leu Met Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Phe Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Leu Val Tyr 
        35                  40                  45              


Arg Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ala Thr Tyr 
                85                  90                  95      


Glu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  169
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  169

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gln Ser Gly Ser Gly Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  170
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  170

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ala Ser Ala Ser Leu Ala Ile Ser Gly Pro Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  171
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  171

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Glu Gly Asn Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  172
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  172

Gln Ser Val Leu Thr Gln Pro Pro Ser Thr Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Trp Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Met Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  173
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  173

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Ala Val Ala Gly Thr Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  174
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  174

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  175
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  175

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Glu Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  176
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  176

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Glu Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ala 
    50                  55                  60                  


Asn Ser Gly Asn Ser Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Arg Thr Ser Gly His 
                85                  90                  95      


Phe Val Phe Gly Pro Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  177
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  177

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Glu Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Arg Gly Thr Gly Ile Asp Tyr Trp Gly Leu Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  178
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  178

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Tyr Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Leu Ser Cys Thr Gly Thr Lys Ser Asp Ile Gly Ala Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Val Tyr Asp Val Ser Asn Arg Pro Ser Gly Leu Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala His Tyr Tyr Cys Ser Ser Tyr Thr Thr Ser 
                85                  90                  95      


Gly Thr Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  179
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  179

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Asp Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  180
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  180

Asp Ile Val Met Thr Gln Ser Pro Glu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Tyr Ser 
            20                  25                  30          


Ser Ser Asn Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Ile Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  181
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  181

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Pro Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Trp Thr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Thr Asp Tyr Gly Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  182
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  182

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 
                85                  90                  95      


Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  183
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  183

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Pro Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asp Gly Asn His Lys Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met His Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asp Leu Ser Gly Ala Glu Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  184
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  184

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  185
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  185

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Ala Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asp Tyr 
            20                  25                  30          


Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Met Ser Tyr Asp Gly Ser Leu Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp Ile Ser Glu Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Ser Asp Gly Asp Phe Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  186
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  186

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Arg Asp Ile Gly Ser Arg Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Thr Ala Arg Pro Ser Glu Ile Arg Ala Arg Phe Ser Gly Phe 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Thr Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  187
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  187

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Phe 
            20                  25                  30          


Pro Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Tyr Asp Gly Ser Phe Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ile 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gly Asp Ser Asp Trp Ala Asp Phe Glu Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  188
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  188

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  189
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  189

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Asn Phe Ser Leu Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Gln Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Glu Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  190
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  190

Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Thr Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Gly Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Gln Leu 
        35                  40                  45              


Leu Ile Tyr Glu Val Ala Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ser Tyr Thr Leu Ser 
                85                  90                  95      


Ser Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  191
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  191

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Asn Thr Arg 
            20                  25                  30          


Gly Met Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Asp Trp Glu Asp Asp Lys Phe Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Met Thr Arg Leu Thr Ile Ser Lys Asp Ile Phe Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Val Asp Pro Val Asp Thr Gly Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Tyr Ser Val Gly Val Lys Tyr Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  192
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  192

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Arg Gln Glu Pro Gly Gln Ala Pro Ile Leu Leu Ile Tyr 
        35                  40                  45              


Gly Gly Asn Tyr Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  193
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  193

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Arg Arg Leu Ser Cys Ala Val Ser Gly Asn Val Thr Ser Ile Thr 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg His Ala Pro Gly Lys Gln Arg Glu Ala Val 
        35                  40                  45              


Gly Ile Ile Asn Asp Asp Asp Arg Thr Arg Tyr Glu Asp Ser Met Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Pro Ala Lys Asn Met Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Lys Ala Gly Gly Asn Phe Tyr Met Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  194
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  194

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser Ile Pro Ser Val Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Val Thr Ser Asp Gly Arg Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Ala Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu 
                85                  90                  95      


Ile Thr Asn Ser Asp His Asn Thr Leu Gly Val Gly Lys Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  195
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  195

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser Ile Pro Ser Val Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Val Thr Ser Asp Gly Arg Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Ala Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu 
                85                  90                  95      


Ile Thr Asn Ser Asp His Asn Thr Leu Gly Val Gly Lys Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  196
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  196

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser Ile Pro Ser Val Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Val Thr Ser Asp Gly Arg Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Ala Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Leu 
                85                  90                  95      


Ile Thr Asn Gln Asp His Asn Thr Leu Gly Val Gly Lys Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  197
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome-related coronavirus-2

<400>  197

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  198
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  198

Ser Leu Arg Asn Tyr Tyr 
1               5       


<210>  199
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  199

Asn Ser Arg Asp Ser Ser Gly Asn His Val Val 
1               5                   10      


<210>  200
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetoc oligonucleotide

<400>  200
acaggtacgt taatagttaa tagcgt                                            26


<210>  201
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  201
atattgcagc agtacgcaca ca                                                22


<210>  202
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  202
acactagcca tccttactgc gcttcg                                            26


<210>  203
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  203

Leu Ile Thr Asn Ser Asp His Asn Thr Leu Gly 
1               5                   10      


<210>  204
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  204

Gly Tyr Ser Phe Thr Ser Tyr 
1               5           


<210>  205
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  205

Tyr Pro Gly Asp Ser Asp 
1               5       


<210>  206
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  206

Leu Gly Asp Tyr Ser Gly Met Asp Val 
1               5                   


<210>  207
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  207

Ser Tyr Trp Ile Gly 
1               5   


<210>  208
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  208

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  209
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  209

Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  210
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  210

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
1               5                   10  


<210>  211
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  211

Thr Ser Tyr Trp Ile Gly 
1               5       


<210>  212
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  212

Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
1               5                   10              


<210>  213
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  213

Ala Arg Leu Gly Asp Tyr Ser Gly Met Asp 
1               5                   10  


<210>  214
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  214

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Thr Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Val Asn Pro Asn Ser Gly Lys Val Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ile Met Thr Arg Ser Asp Ser Glu Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Gln Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Thr Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  215
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  215

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Ile Pro Ile Phe Asp Lys Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Gly Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


