                         SEQUENCE LISTING

<110>  Spark Therapeutics
 
<120>  Compositions and Methods for Treating Hereditary Angioedma

<130>  065830.11035/5WO1

<150> US 63/142,121
<151> 2021-01-27

<150> US 63/201,466
<151> 2021-04-30

<150> US 63/261,603
<151> 2021-09-21

<160>  269   

<170>  PatentIn version 3.5

<210>  1
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1_BGH228

<400>  1
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

gctgctggct ggggatagag cctcctcaaa tccaaatgct accagctcca gctcccagga     1500

tccagagagt ttgcaagaca gaggcgaagg gaaggtcgca acaacagtta tctccaagat     1560

gctattcgtt gaacccatcc tggaggtttc cagcttgccg acaaccaact caacaaccaa     1620

ttcagccacc aaaataacag ctaataccac tgatgaaccc accacacaac ccaccacaga     1680

gcccaccacc caacccacca tccaacccac ccaaccaact acccagctcc caacagattc     1740

tcctacccag cccactactg ggtccttctg cccaggacct gttactctct gctctgactt     1800

ggagagtcat tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct     1860

ctaccacgcc ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag     1920

catcgccagc ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct     1980

ggagagcatc ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacgaccaaa ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag     2100

ggacaccttt gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa     2160

caacagtgac gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagccgg ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat     2280

ctacctgagt gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt     2340

tcacttcaaa aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc     2400

ccatttcatt gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct     2460

gagtttggtg atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc     2520

tctcagccct tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc     2580

cactctccta acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat     2640

ggagaaattg gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga     2700

ccctgatctt caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaggcg gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt     2820

gcagcagccc ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg     2880

gcgagtatat gaccccaggg cctgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  2
<211>  3340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SP7.SERPING1_BGH228

<400>  2
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctt tctgtggctg ctgtcctgct gggccctgct     1440

ggggaccacc tttggcaatc caaatgctac cagctccagc tcccaggatc cagagagttt     1500

gcaagacaga ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga     1560

acccatcctg gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa     1620

aataacagct aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca     1680

acccaccatc caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc     1740

cactactggg tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc     1800

aacagaggcc gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt     1860

ctcagcaatg aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct     1920

ccttacccag gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct     1980

ctcttacccc aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg     2040

tgtcacctca gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt     2100

gaatgcctct cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc     2160

caacttggag ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct     2220

gctagacagt ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc     2280

caagtggaag acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa     2340

ctcagttata aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga     2400

ccaaactttg aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat     2460

cctggtaccc cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc     2520

tgttttcaag gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac     2580

actaccccgc atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga     2640

attcttcgat ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca     2700

ggtttctgcg atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc     2760

tgcagcctcc gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt     2820

cctcttcgtg ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga     2880

ccccagggcc tgaagatcta gagctgaatt cctgcagcca gggggatcag cctctactgt     2940

gccttctagt tgccagccat ctgttgtttg cccctccccc ttgccttcct tgaccctgga     3000

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcac attgtctgag     3060

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     3120

agacaatagc aggcatgctg gggatgcagt gggctctatg gcttctgagg cagaaagaac     3180

cagctggggc tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     3240

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     3300

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                           3340


<210>  3
<211>  3340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_ALB.SERPING1_BGH228

<400>  3
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgaagtg ggtaaccttt atttcccttc tttttctctt     1440

tagctcggct tattccaatc caaatgctac cagctccagc tcccaggatc cagagagttt     1500

gcaagacaga ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga     1560

acccatcctg gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa     1620

aataacagct aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca     1680

acccaccatc caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc     1740

cactactggg tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc     1800

aacagaggcc gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt     1860

ctcagcaatg aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct     1920

ccttacccag gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct     1980

ctcttacccc aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg     2040

tgtcacctca gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt     2100

gaatgcctct cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc     2160

caacttggag ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct     2220

gctagacagt ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc     2280

caagtggaag acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa     2340

ctcagttata aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga     2400

ccaaactttg aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat     2460

cctggtaccc cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc     2520

tgttttcaag gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac     2580

actaccccgc atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga     2640

attcttcgat ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca     2700

ggtttctgcg atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc     2760

tgcagcctcc gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt     2820

cctcttcgtg ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga     2880

ccccagggcc tgaagatcta gagctgaatt cctgcagcca gggggatcag cctctactgt     2940

gccttctagt tgccagccat ctgttgtttg cccctccccc ttgccttcct tgaccctgga     3000

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcac attgtctgag     3060

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     3120

agacaatagc aggcatgctg gggatgcagt gggctctatg gcttctgagg cagaaagaac     3180

cagctggggc tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     3240

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     3300

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                           3340


<210>  4
<211>  3340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_ORM1.SERPING1_BGH228

<400>  4
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcgct gtcctgggtt cttacagtcc tgagcctcct     1440

acctctgctg gaagccaatc caaatgctac cagctccagc tcccaggatc cagagagttt     1500

gcaagacaga ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga     1560

acccatcctg gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa     1620

aataacagct aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca     1680

acccaccatc caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc     1740

cactactggg tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc     1800

aacagaggcc gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt     1860

ctcagcaatg aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct     1920

ccttacccag gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct     1980

ctcttacccc aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg     2040

tgtcacctca gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt     2100

gaatgcctct cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc     2160

caacttggag ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct     2220

gctagacagt ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc     2280

caagtggaag acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa     2340

ctcagttata aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga     2400

ccaaactttg aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat     2460

cctggtaccc cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc     2520

tgttttcaag gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac     2580

actaccccgc atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga     2640

attcttcgat ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca     2700

ggtttctgcg atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc     2760

tgcagcctcc gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt     2820

cctcttcgtg ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga     2880

ccccagggcc tgaagatcta gagctgaatt cctgcagcca gggggatcag cctctactgt     2940

gccttctagt tgccagccat ctgttgtttg cccctccccc ttgccttcct tgaccctgga     3000

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcac attgtctgag     3060

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     3120

agacaatagc aggcatgctg gggatgcagt gggctctatg gcttctgagg cagaaagaac     3180

cagctggggc tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     3240

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     3300

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                           3340


<210>  5
<211>  3343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_TF.SERPING1_BGH228

<400>  5
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgaggct cgccgtggga gccctgctgg tctgcgccgt     1440

cctggggctg tgtctggcta atccaaatgc taccagctcc agctcccagg atccagagag     1500

tttgcaagac agaggcgaag ggaaggtcgc aacaacagtt atctccaaga tgctattcgt     1560

tgaacccatc ctggaggttt ccagcttgcc gacaaccaac tcaacaacca attcagccac     1620

caaaataaca gctaatacca ctgatgaacc caccacacaa cccaccacag agcccaccac     1680

ccaacccacc atccaaccca cccaaccaac tacccagctc ccaacagatt ctcctaccca     1740

gcccactact gggtccttct gcccaggacc tgttactctc tgctctgact tggagagtca     1800

ttcaacagag gccgtgttgg gggatgcttt ggtagatttc tccctgaagc tctaccacgc     1860

cttctcagca atgaagaagg tggagaccaa catggccttt tccccattca gcatcgccag     1920

cctccttacc caggtcctgc tcggggctgg ggagaacacc aaaacaaacc tggagagcat     1980

cctctcttac cccaaggact tcacctgtgt ccaccaggcc ctgaagggct tcacgaccaa     2040

aggtgtcacc tcagtctctc agattttcca cagcccagac ctggccataa gggacacctt     2100

tgtgaatgcc tctcggaccc tgtacagcag cagccccaga gtcctaagca acaacagtga     2160

cgccaacttg gagctcatca acacctgggt ggccaagaac accaacaaca agatcagccg     2220

gctgctagac agtctgccct ccgatacccg ccttgtcctc ctcaatgcta tctacctgag     2280

tgccaagtgg aagacaacat ttgatcccaa gaaaaccaga atggaaccct ttcacttcaa     2340

aaactcagtt ataaaagtgc ccatgatgaa tagcaagaag taccctgtgg cccatttcat     2400

tgaccaaact ttgaaagcca aggtggggca gctgcagctc tcccacaatc tgagtttggt     2460

gatcctggta ccccagaacc tgaaacatcg tcttgaagac atggaacagg ctctcagccc     2520

ttctgttttc aaggccatca tggagaaact ggagatgtcc aagttccagc ccactctcct     2580

aacactaccc cgcatcaaag tgacgaccag ccaggatatg ctctcaatca tggagaaatt     2640

ggaattcttc gatttttctt atgaccttaa cctgtgtggg ctgacagagg accctgatct     2700

tcaggtttct gcgatgcagc accagacagt gctggaactg acagagactg gggtggaggc     2760

ggctgcagcc tccgccatct ctgtggcccg caccctgctg gtctttgaag tgcagcagcc     2820

cttcctcttc gtgctctggg accagcagca caagttccct gtcttcatgg ggcgagtata     2880

tgaccccagg gcctgaagat ctagagctga attcctgcag ccagggggat cagcctctac     2940

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccttgcctt ccttgaccct     3000

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cacattgtct     3060

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     3120

ggaagacaat agcaggcatg ctggggatgc agtgggctct atggcttctg aggcagaaag     3180

aaccagctgg ggctcgagat ccactagggc cgcaggaacc cctagtgatg gagttggcca     3240

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     3300

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag                       3343


<210>  6
<211>  3343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_AMBP.SERPING1_BGH228

<400>  6
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgaggag cctcggggcc ctgctcttgc tgctgagcgc     1440

ctgcctggcg gtgagcgcta atccaaatgc taccagctcc agctcccagg atccagagag     1500

tttgcaagac agaggcgaag ggaaggtcgc aacaacagtt atctccaaga tgctattcgt     1560

tgaacccatc ctggaggttt ccagcttgcc gacaaccaac tcaacaacca attcagccac     1620

caaaataaca gctaatacca ctgatgaacc caccacacaa cccaccacag agcccaccac     1680

ccaacccacc atccaaccca cccaaccaac tacccagctc ccaacagatt ctcctaccca     1740

gcccactact gggtccttct gcccaggacc tgttactctc tgctctgact tggagagtca     1800

ttcaacagag gccgtgttgg gggatgcttt ggtagatttc tccctgaagc tctaccacgc     1860

cttctcagca atgaagaagg tggagaccaa catggccttt tccccattca gcatcgccag     1920

cctccttacc caggtcctgc tcggggctgg ggagaacacc aaaacaaacc tggagagcat     1980

cctctcttac cccaaggact tcacctgtgt ccaccaggcc ctgaagggct tcacgaccaa     2040

aggtgtcacc tcagtctctc agattttcca cagcccagac ctggccataa gggacacctt     2100

tgtgaatgcc tctcggaccc tgtacagcag cagccccaga gtcctaagca acaacagtga     2160

cgccaacttg gagctcatca acacctgggt ggccaagaac accaacaaca agatcagccg     2220

gctgctagac agtctgccct ccgatacccg ccttgtcctc ctcaatgcta tctacctgag     2280

tgccaagtgg aagacaacat ttgatcccaa gaaaaccaga atggaaccct ttcacttcaa     2340

aaactcagtt ataaaagtgc ccatgatgaa tagcaagaag taccctgtgg cccatttcat     2400

tgaccaaact ttgaaagcca aggtggggca gctgcagctc tcccacaatc tgagtttggt     2460

gatcctggta ccccagaacc tgaaacatcg tcttgaagac atggaacagg ctctcagccc     2520

ttctgttttc aaggccatca tggagaaact ggagatgtcc aagttccagc ccactctcct     2580

aacactaccc cgcatcaaag tgacgaccag ccaggatatg ctctcaatca tggagaaatt     2640

ggaattcttc gatttttctt atgaccttaa cctgtgtggg ctgacagagg accctgatct     2700

tcaggtttct gcgatgcagc accagacagt gctggaactg acagagactg gggtggaggc     2760

ggctgcagcc tccgccatct ctgtggcccg caccctgctg gtctttgaag tgcagcagcc     2820

cttcctcttc gtgctctggg accagcagca caagttccct gtcttcatgg ggcgagtata     2880

tgaccccagg gcctgaagat ctagagctga attcctgcag ccagggggat cagcctctac     2940

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccttgcctt ccttgaccct     3000

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cacattgtct     3060

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     3120

ggaagacaat agcaggcatg ctggggatgc agtgggctct atggcttctg aggcagaaag     3180

aaccagctgg ggctcgagat ccactagggc cgcaggaacc cctagtgatg gagttggcca     3240

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     3300

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag                       3343


<210>  7
<211>  3370
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_LAMP1.SERPING1_BGH228

<400>  7
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcggc ccccggcagc gcccggcgac ccctgctgct     1440

gctactgctg ttgctgctgc tcggcctcat gcattgtgcg tcagcaaatc caaatgctac     1500

cagctccagc tcccaggatc cagagagttt gcaagacaga ggcgaaggga aggtcgcaac     1560

aacagttatc tccaagatgc tattcgttga acccatcctg gaggtttcca gcttgccgac     1620

aaccaactca acaaccaatt cagccaccaa aataacagct aataccactg atgaacccac     1680

cacacaaccc accacagagc ccaccaccca acccaccatc caacccaccc aaccaactac     1740

ccagctccca acagattctc ctacccagcc cactactggg tccttctgcc caggacctgt     1800

tactctctgc tctgacttgg agagtcattc aacagaggcc gtgttggggg atgctttggt     1860

agatttctcc ctgaagctct accacgcctt ctcagcaatg aagaaggtgg agaccaacat     1920

ggccttttcc ccattcagca tcgccagcct ccttacccag gtcctgctcg gggctgggga     1980

gaacaccaaa acaaacctgg agagcatcct ctcttacccc aaggacttca cctgtgtcca     2040

ccaggccctg aagggcttca cgaccaaagg tgtcacctca gtctctcaga ttttccacag     2100

cccagacctg gccataaggg acacctttgt gaatgcctct cggaccctgt acagcagcag     2160

ccccagagtc ctaagcaaca acagtgacgc caacttggag ctcatcaaca cctgggtggc     2220

caagaacacc aacaacaaga tcagccggct gctagacagt ctgccctccg atacccgcct     2280

tgtcctcctc aatgctatct acctgagtgc caagtggaag acaacatttg atcccaagaa     2340

aaccagaatg gaaccctttc acttcaaaaa ctcagttata aaagtgccca tgatgaatag     2400

caagaagtac cctgtggccc atttcattga ccaaactttg aaagccaagg tggggcagct     2460

gcagctctcc cacaatctga gtttggtgat cctggtaccc cagaacctga aacatcgtct     2520

tgaagacatg gaacaggctc tcagcccttc tgttttcaag gccatcatgg agaaactgga     2580

gatgtccaag ttccagccca ctctcctaac actaccccgc atcaaagtga cgaccagcca     2640

ggatatgctc tcaatcatgg agaaattgga attcttcgat ttttcttatg accttaacct     2700

gtgtgggctg acagaggacc ctgatcttca ggtttctgcg atgcagcacc agacagtgct     2760

ggaactgaca gagactgggg tggaggcggc tgcagcctcc gccatctctg tggcccgcac     2820

cctgctggtc tttgaagtgc agcagccctt cctcttcgtg ctctgggacc agcagcacaa     2880

gttccctgtc ttcatggggc gagtatatga ccccagggcc tgaagatcta gagctgaatt     2940

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     3000

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     3060

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     3120

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     3180

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     3240

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     3300

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     3360

gagcgcgcag                                                            3370


<210>  8
<211>  3382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_BTN2A2.SERPING1_BGH228

<400>  8
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggaacc agctgctgct ctgcacttct ccctgccagc     1440

ctccctcctc ctcctcctgc tcctcctcct tctcagcctg tgtgcactgg tctcagccaa     1500

tccaaatgct accagctcca gctcccagga tccagagagt ttgcaagaca gaggcgaagg     1560

gaaggtcgca acaacagtta tctccaagat gctattcgtt gaacccatcc tggaggtttc     1620

cagcttgccg acaaccaact caacaaccaa ttcagccacc aaaataacag ctaataccac     1680

tgatgaaccc accacacaac ccaccacaga gcccaccacc caacccacca tccaacccac     1740

ccaaccaact acccagctcc caacagattc tcctacccag cccactactg ggtccttctg     1800

cccaggacct gttactctct gctctgactt ggagagtcat tcaacagagg ccgtgttggg     1860

ggatgctttg gtagatttct ccctgaagct ctaccacgcc ttctcagcaa tgaagaaggt     1920

ggagaccaac atggcctttt ccccattcag catcgccagc ctccttaccc aggtcctgct     1980

cggggctggg gagaacacca aaacaaacct ggagagcatc ctctcttacc ccaaggactt     2040

cacctgtgtc caccaggccc tgaagggctt cacgaccaaa ggtgtcacct cagtctctca     2100

gattttccac agcccagacc tggccataag ggacaccttt gtgaatgcct ctcggaccct     2160

gtacagcagc agccccagag tcctaagcaa caacagtgac gccaacttgg agctcatcaa     2220

cacctgggtg gccaagaaca ccaacaacaa gatcagccgg ctgctagaca gtctgccctc     2280

cgatacccgc cttgtcctcc tcaatgctat ctacctgagt gccaagtgga agacaacatt     2340

tgatcccaag aaaaccagaa tggaaccctt tcacttcaaa aactcagtta taaaagtgcc     2400

catgatgaat agcaagaagt accctgtggc ccatttcatt gaccaaactt tgaaagccaa     2460

ggtggggcag ctgcagctct cccacaatct gagtttggtg atcctggtac cccagaacct     2520

gaaacatcgt cttgaagaca tggaacaggc tctcagccct tctgttttca aggccatcat     2580

ggagaaactg gagatgtcca agttccagcc cactctccta acactacccc gcatcaaagt     2640

gacgaccagc caggatatgc tctcaatcat ggagaaattg gaattcttcg atttttctta     2700

tgaccttaac ctgtgtgggc tgacagagga ccctgatctt caggtttctg cgatgcagca     2760

ccagacagtg ctggaactga cagagactgg ggtggaggcg gctgcagcct ccgccatctc     2820

tgtggcccgc accctgctgg tctttgaagt gcagcagccc ttcctcttcg tgctctggga     2880

ccagcagcac aagttccctg tcttcatggg gcgagtatat gaccccaggg cctgaagatc     2940

tagagctgaa ttcctgcagc cagggggatc agcctctact gtgccttcta gttgccagcc     3000

atctgttgtt tgcccctccc ccttgccttc cttgaccctg gaaggtgcca ctcccactgt     3060

cctttcctaa taaaatgagg aaattgcatc acattgtctg agtaggtgtc attctattct     3120

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     3180

tggggatgca gtgggctcta tggcttctga ggcagaaaga accagctggg gctcgagatc     3240

cactagggcc gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3300

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3360

cagtgagcga gcgagcgcgc ag                                              3382


<210>  9
<211>  3337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_CD300.SERPING1_BGH228

<400>  9
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgtggct gccttgggct ctgttgcttc tctgggtccc     1440

aggatgtttt gctaatccaa atgctaccag ctccagctcc caggatccag agagtttgca     1500

agacagaggc gaagggaagg tcgcaacaac agttatctcc aagatgctat tcgttgaacc     1560

catcctggag gtttccagct tgccgacaac caactcaaca accaattcag ccaccaaaat     1620

aacagctaat accactgatg aacccaccac acaacccacc acagagccca ccacccaacc     1680

caccatccaa cccacccaac caactaccca gctcccaaca gattctccta cccagcccac     1740

tactgggtcc ttctgcccag gacctgttac tctctgctct gacttggaga gtcattcaac     1800

agaggccgtg ttgggggatg ctttggtaga tttctccctg aagctctacc acgccttctc     1860

agcaatgaag aaggtggaga ccaacatggc cttttcccca ttcagcatcg ccagcctcct     1920

tacccaggtc ctgctcgggg ctggggagaa caccaaaaca aacctggaga gcatcctctc     1980

ttaccccaag gacttcacct gtgtccacca ggccctgaag ggcttcacga ccaaaggtgt     2040

cacctcagtc tctcagattt tccacagccc agacctggcc ataagggaca cctttgtgaa     2100

tgcctctcgg accctgtaca gcagcagccc cagagtccta agcaacaaca gtgacgccaa     2160

cttggagctc atcaacacct gggtggccaa gaacaccaac aacaagatca gccggctgct     2220

agacagtctg ccctccgata cccgccttgt cctcctcaat gctatctacc tgagtgccaa     2280

gtggaagaca acatttgatc ccaagaaaac cagaatggaa ccctttcact tcaaaaactc     2340

agttataaaa gtgcccatga tgaatagcaa gaagtaccct gtggcccatt tcattgacca     2400

aactttgaaa gccaaggtgg ggcagctgca gctctcccac aatctgagtt tggtgatcct     2460

ggtaccccag aacctgaaac atcgtcttga agacatggaa caggctctca gcccttctgt     2520

tttcaaggcc atcatggaga aactggagat gtccaagttc cagcccactc tcctaacact     2580

accccgcatc aaagtgacga ccagccagga tatgctctca atcatggaga aattggaatt     2640

cttcgatttt tcttatgacc ttaacctgtg tgggctgaca gaggaccctg atcttcaggt     2700

ttctgcgatg cagcaccaga cagtgctgga actgacagag actggggtgg aggcggctgc     2760

agcctccgcc atctctgtgg cccgcaccct gctggtcttt gaagtgcagc agcccttcct     2820

cttcgtgctc tgggaccagc agcacaagtt ccctgtcttc atggggcgag tatatgaccc     2880

cagggcctga agatctagag ctgaattcct gcagccaggg ggatcagcct ctactgtgcc     2940

ttctagttgc cagccatctg ttgtttgccc ctcccccttg ccttccttga ccctggaagg     3000

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcacatt gtctgagtag     3060

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     3120

caatagcagg catgctgggg atgcagtggg ctctatggct tctgaggcag aaagaaccag     3180

ctggggctcg agatccacta gggccgcagg aacccctagt gatggagttg gccactccct     3240

ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct     3300

ttgcccgggc ggcctcagtg agcgagcgag cgcgcag                              3337


<210>  10
<211>  3361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_NOTCH2.SERPING1_BGH228

<400>  10
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgcccgc cctgcgcccc gctctgctgt gggcgctgct     1440

ggcgctctgg ctgtgctgcg cggcccccgc gcatgcaaat ccaaatgcta ccagctccag     1500

ctcccaggat ccagagagtt tgcaagacag aggcgaaggg aaggtcgcaa caacagttat     1560

ctccaagatg ctattcgttg aacccatcct ggaggtttcc agcttgccga caaccaactc     1620

aacaaccaat tcagccacca aaataacagc taataccact gatgaaccca ccacacaacc     1680

caccacagag cccaccaccc aacccaccat ccaacccacc caaccaacta cccagctccc     1740

aacagattct cctacccagc ccactactgg gtccttctgc ccaggacctg ttactctctg     1800

ctctgacttg gagagtcatt caacagaggc cgtgttgggg gatgctttgg tagatttctc     1860

cctgaagctc taccacgcct tctcagcaat gaagaaggtg gagaccaaca tggccttttc     1920

cccattcagc atcgccagcc tccttaccca ggtcctgctc ggggctgggg agaacaccaa     1980

aacaaacctg gagagcatcc tctcttaccc caaggacttc acctgtgtcc accaggccct     2040

gaagggcttc acgaccaaag gtgtcacctc agtctctcag attttccaca gcccagacct     2100

ggccataagg gacacctttg tgaatgcctc tcggaccctg tacagcagca gccccagagt     2160

cctaagcaac aacagtgacg ccaacttgga gctcatcaac acctgggtgg ccaagaacac     2220

caacaacaag atcagccggc tgctagacag tctgccctcc gatacccgcc ttgtcctcct     2280

caatgctatc tacctgagtg ccaagtggaa gacaacattt gatcccaaga aaaccagaat     2340

ggaacccttt cacttcaaaa actcagttat aaaagtgccc atgatgaata gcaagaagta     2400

ccctgtggcc catttcattg accaaacttt gaaagccaag gtggggcagc tgcagctctc     2460

ccacaatctg agtttggtga tcctggtacc ccagaacctg aaacatcgtc ttgaagacat     2520

ggaacaggct ctcagccctt ctgttttcaa ggccatcatg gagaaactgg agatgtccaa     2580

gttccagccc actctcctaa cactaccccg catcaaagtg acgaccagcc aggatatgct     2640

ctcaatcatg gagaaattgg aattcttcga tttttcttat gaccttaacc tgtgtgggct     2700

gacagaggac cctgatcttc aggtttctgc gatgcagcac cagacagtgc tggaactgac     2760

agagactggg gtggaggcgg ctgcagcctc cgccatctct gtggcccgca ccctgctggt     2820

ctttgaagtg cagcagccct tcctcttcgt gctctgggac cagcagcaca agttccctgt     2880

cttcatgggg cgagtatatg accccagggc ctgaagatct agagctgaat tcctgcagcc     2940

agggggatca gcctctactg tgccttctag ttgccagcca tctgttgttt gcccctcccc     3000

cttgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga     3060

aattgcatca cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga     3120

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcag tgggctctat     3180

ggcttctgag gcagaaagaa ccagctgggg ctcgagatcc actagggccg caggaacccc     3240

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     3300

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     3360

g                                                                     3361


<210>  11
<211>  3349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_STRC.SERPING1_BGH228

<400>  11
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggctct cagcctctgg cccctgctgc tgctgctgct     1440

gctgctgctg ctgctgtcct ttgcaaatcc aaatgctacc agctccagct cccaggatcc     1500

agagagtttg caagacagag gcgaagggaa ggtcgcaaca acagttatct ccaagatgct     1560

attcgttgaa cccatcctgg aggtttccag cttgccgaca accaactcaa caaccaattc     1620

agccaccaaa ataacagcta ataccactga tgaacccacc acacaaccca ccacagagcc     1680

caccacccaa cccaccatcc aacccaccca accaactacc cagctcccaa cagattctcc     1740

tacccagccc actactgggt ccttctgccc aggacctgtt actctctgct ctgacttgga     1800

gagtcattca acagaggccg tgttggggga tgctttggta gatttctccc tgaagctcta     1860

ccacgccttc tcagcaatga agaaggtgga gaccaacatg gccttttccc cattcagcat     1920

cgccagcctc cttacccagg tcctgctcgg ggctggggag aacaccaaaa caaacctgga     1980

gagcatcctc tcttacccca aggacttcac ctgtgtccac caggccctga agggcttcac     2040

gaccaaaggt gtcacctcag tctctcagat tttccacagc ccagacctgg ccataaggga     2100

cacctttgtg aatgcctctc ggaccctgta cagcagcagc cccagagtcc taagcaacaa     2160

cagtgacgcc aacttggagc tcatcaacac ctgggtggcc aagaacacca acaacaagat     2220

cagccggctg ctagacagtc tgccctccga tacccgcctt gtcctcctca atgctatcta     2280

cctgagtgcc aagtggaaga caacatttga tcccaagaaa accagaatgg aaccctttca     2340

cttcaaaaac tcagttataa aagtgcccat gatgaatagc aagaagtacc ctgtggccca     2400

tttcattgac caaactttga aagccaaggt ggggcagctg cagctctccc acaatctgag     2460

tttggtgatc ctggtacccc agaacctgaa acatcgtctt gaagacatgg aacaggctct     2520

cagcccttct gttttcaagg ccatcatgga gaaactggag atgtccaagt tccagcccac     2580

tctcctaaca ctaccccgca tcaaagtgac gaccagccag gatatgctct caatcatgga     2640

gaaattggaa ttcttcgatt tttcttatga ccttaacctg tgtgggctga cagaggaccc     2700

tgatcttcag gtttctgcga tgcagcacca gacagtgctg gaactgacag agactggggt     2760

ggaggcggct gcagcctccg ccatctctgt ggcccgcacc ctgctggtct ttgaagtgca     2820

gcagcccttc ctcttcgtgc tctgggacca gcagcacaag ttccctgtct tcatggggcg     2880

agtatatgac cccagggcct gaagatctag agctgaattc ctgcagccag ggggatcagc     2940

ctctactgtg ccttctagtt gccagccatc tgttgtttgc ccctccccct tgccttcctt     3000

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcaca     3060

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3120

ggattgggaa gacaatagca ggcatgctgg ggatgcagtg ggctctatgg cttctgaggc     3180

agaaagaacc agctggggct cgagatccac tagggccgca ggaaccccta gtgatggagt     3240

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     3300

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 3349


<210>  12
<211>  3340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_AHSG.SERPING1_BGH228

<400>  12
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgaagtc cctcgtcctg ctcctttgtc ttgctcagct     1440

ctggggctgc cactcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt     1500

gcaagacaga ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga     1560

acccatcctg gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa     1620

aataacagct aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca     1680

acccaccatc caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc     1740

cactactggg tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc     1800

aacagaggcc gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt     1860

ctcagcaatg aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct     1920

ccttacccag gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct     1980

ctcttacccc aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg     2040

tgtcacctca gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt     2100

gaatgcctct cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc     2160

caacttggag ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct     2220

gctagacagt ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc     2280

caagtggaag acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa     2340

ctcagttata aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga     2400

ccaaactttg aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat     2460

cctggtaccc cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc     2520

tgttttcaag gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac     2580

actaccccgc atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga     2640

attcttcgat ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca     2700

ggtttctgcg atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc     2760

tgcagcctcc gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt     2820

cctcttcgtg ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga     2880

ccccagggcc tgaagatcta gagctgaatt cctgcagcca gggggatcag cctctactgt     2940

gccttctagt tgccagccat ctgttgtttg cccctccccc ttgccttcct tgaccctgga     3000

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcac attgtctgag     3060

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     3120

agacaatagc aggcatgctg gggatgcagt gggctctatg gcttctgagg cagaaagaac     3180

cagctggggc tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     3240

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     3300

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                           3340


<210>  13
<211>  3349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SYN1.SERPING1_BGH228

<400>  13
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgaagtt cgccctggtg gccgccctgg ccctgctgct     1440

gttcctgtgg agcagctgca gggccaatcc aaatgctacc agctccagct cccaggatcc     1500

agagagtttg caagacagag gcgaagggaa ggtcgcaaca acagttatct ccaagatgct     1560

attcgttgaa cccatcctgg aggtttccag cttgccgaca accaactcaa caaccaattc     1620

agccaccaaa ataacagcta ataccactga tgaacccacc acacaaccca ccacagagcc     1680

caccacccaa cccaccatcc aacccaccca accaactacc cagctcccaa cagattctcc     1740

tacccagccc actactgggt ccttctgccc aggacctgtt actctctgct ctgacttgga     1800

gagtcattca acagaggccg tgttggggga tgctttggta gatttctccc tgaagctcta     1860

ccacgccttc tcagcaatga agaaggtgga gaccaacatg gccttttccc cattcagcat     1920

cgccagcctc cttacccagg tcctgctcgg ggctggggag aacaccaaaa caaacctgga     1980

gagcatcctc tcttacccca aggacttcac ctgtgtccac caggccctga agggcttcac     2040

gaccaaaggt gtcacctcag tctctcagat tttccacagc ccagacctgg ccataaggga     2100

cacctttgtg aatgcctctc ggaccctgta cagcagcagc cccagagtcc taagcaacaa     2160

cagtgacgcc aacttggagc tcatcaacac ctgggtggcc aagaacacca acaacaagat     2220

cagccggctg ctagacagtc tgccctccga tacccgcctt gtcctcctca atgctatcta     2280

cctgagtgcc aagtggaaga caacatttga tcccaagaaa accagaatgg aaccctttca     2340

cttcaaaaac tcagttataa aagtgcccat gatgaatagc aagaagtacc ctgtggccca     2400

tttcattgac caaactttga aagccaaggt ggggcagctg cagctctccc acaatctgag     2460

tttggtgatc ctggtacccc agaacctgaa acatcgtctt gaagacatgg aacaggctct     2520

cagcccttct gttttcaagg ccatcatgga gaaactggag atgtccaagt tccagcccac     2580

tctcctaaca ctaccccgca tcaaagtgac gaccagccag gatatgctct caatcatgga     2640

gaaattggaa ttcttcgatt tttcttatga ccttaacctg tgtgggctga cagaggaccc     2700

tgatcttcag gtttctgcga tgcagcacca gacagtgctg gaactgacag agactggggt     2760

ggaggcggct gcagcctccg ccatctctgt ggcccgcacc ctgctggtct ttgaagtgca     2820

gcagcccttc ctcttcgtgc tctgggacca gcagcacaag ttccctgtct tcatggggcg     2880

agtatatgac cccagggcct gaagatctag agctgaattc ctgcagccag ggggatcagc     2940

ctctactgtg ccttctagtt gccagccatc tgttgtttgc ccctccccct tgccttcctt     3000

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcaca     3060

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3120

ggattgggaa gacaatagca ggcatgctgg ggatgcagtg ggctctatgg cttctgaggc     3180

agaaagaacc agctggggct cgagatccac tagggccgca ggaaccccta gtgatggagt     3240

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     3300

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 3349


<210>  14
<211>  3346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SYN2.SERPING1_BGH228

<400>  14
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgaagtt cgccctggtg gccgccctgg ccctgctgct     1440

gttcctgtgg ggctgccaca gcaatccaaa tgctaccagc tccagctccc aggatccaga     1500

gagtttgcaa gacagaggcg aagggaaggt cgcaacaaca gttatctcca agatgctatt     1560

cgttgaaccc atcctggagg tttccagctt gccgacaacc aactcaacaa ccaattcagc     1620

caccaaaata acagctaata ccactgatga acccaccaca caacccacca cagagcccac     1680

cacccaaccc accatccaac ccacccaacc aactacccag ctcccaacag attctcctac     1740

ccagcccact actgggtcct tctgcccagg acctgttact ctctgctctg acttggagag     1800

tcattcaaca gaggccgtgt tgggggatgc tttggtagat ttctccctga agctctacca     1860

cgccttctca gcaatgaaga aggtggagac caacatggcc ttttccccat tcagcatcgc     1920

cagcctcctt acccaggtcc tgctcggggc tggggagaac accaaaacaa acctggagag     1980

catcctctct taccccaagg acttcacctg tgtccaccag gccctgaagg gcttcacgac     2040

caaaggtgtc acctcagtct ctcagatttt ccacagccca gacctggcca taagggacac     2100

ctttgtgaat gcctctcgga ccctgtacag cagcagcccc agagtcctaa gcaacaacag     2160

tgacgccaac ttggagctca tcaacacctg ggtggccaag aacaccaaca acaagatcag     2220

ccggctgcta gacagtctgc cctccgatac ccgccttgtc ctcctcaatg ctatctacct     2280

gagtgccaag tggaagacaa catttgatcc caagaaaacc agaatggaac cctttcactt     2340

caaaaactca gttataaaag tgcccatgat gaatagcaag aagtaccctg tggcccattt     2400

cattgaccaa actttgaaag ccaaggtggg gcagctgcag ctctcccaca atctgagttt     2460

ggtgatcctg gtaccccaga acctgaaaca tcgtcttgaa gacatggaac aggctctcag     2520

cccttctgtt ttcaaggcca tcatggagaa actggagatg tccaagttcc agcccactct     2580

cctaacacta ccccgcatca aagtgacgac cagccaggat atgctctcaa tcatggagaa     2640

attggaattc ttcgattttt cttatgacct taacctgtgt gggctgacag aggaccctga     2700

tcttcaggtt tctgcgatgc agcaccagac agtgctggaa ctgacagaga ctggggtgga     2760

ggcggctgca gcctccgcca tctctgtggc ccgcaccctg ctggtctttg aagtgcagca     2820

gcccttcctc ttcgtgctct gggaccagca gcacaagttc cctgtcttca tggggcgagt     2880

atatgacccc agggcctgaa gatctagagc tgaattcctg cagccagggg gatcagcctc     2940

tactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccttgc cttccttgac     3000

cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcacattg     3060

tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga     3120

ttgggaagac aatagcaggc atgctgggga tgcagtgggc tctatggctt ctgaggcaga     3180

aagaaccagc tggggctcga gatccactag ggccgcagga acccctagtg atggagttgg     3240

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     3300

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcag                    3346


<210>  15
<211>  3349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SYN3.SERPING1_BGH228

<400>  15
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgaagtg ggtgaccctg ctgaccctgc tgctgctgct     1440

gctgttcctg tggggctgcc acagcaatcc aaatgctacc agctccagct cccaggatcc     1500

agagagtttg caagacagag gcgaagggaa ggtcgcaaca acagttatct ccaagatgct     1560

attcgttgaa cccatcctgg aggtttccag cttgccgaca accaactcaa caaccaattc     1620

agccaccaaa ataacagcta ataccactga tgaacccacc acacaaccca ccacagagcc     1680

caccacccaa cccaccatcc aacccaccca accaactacc cagctcccaa cagattctcc     1740

tacccagccc actactgggt ccttctgccc aggacctgtt actctctgct ctgacttgga     1800

gagtcattca acagaggccg tgttggggga tgctttggta gatttctccc tgaagctcta     1860

ccacgccttc tcagcaatga agaaggtgga gaccaacatg gccttttccc cattcagcat     1920

cgccagcctc cttacccagg tcctgctcgg ggctggggag aacaccaaaa caaacctgga     1980

gagcatcctc tcttacccca aggacttcac ctgtgtccac caggccctga agggcttcac     2040

gaccaaaggt gtcacctcag tctctcagat tttccacagc ccagacctgg ccataaggga     2100

cacctttgtg aatgcctctc ggaccctgta cagcagcagc cccagagtcc taagcaacaa     2160

cagtgacgcc aacttggagc tcatcaacac ctgggtggcc aagaacacca acaacaagat     2220

cagccggctg ctagacagtc tgccctccga tacccgcctt gtcctcctca atgctatcta     2280

cctgagtgcc aagtggaaga caacatttga tcccaagaaa accagaatgg aaccctttca     2340

cttcaaaaac tcagttataa aagtgcccat gatgaatagc aagaagtacc ctgtggccca     2400

tttcattgac caaactttga aagccaaggt ggggcagctg cagctctccc acaatctgag     2460

tttggtgatc ctggtacccc agaacctgaa acatcgtctt gaagacatgg aacaggctct     2520

cagcccttct gttttcaagg ccatcatgga gaaactggag atgtccaagt tccagcccac     2580

tctcctaaca ctaccccgca tcaaagtgac gaccagccag gatatgctct caatcatgga     2640

gaaattggaa ttcttcgatt tttcttatga ccttaacctg tgtgggctga cagaggaccc     2700

tgatcttcag gtttctgcga tgcagcacca gacagtgctg gaactgacag agactggggt     2760

ggaggcggct gcagcctccg ccatctctgt ggcccgcacc ctgctggtct ttgaagtgca     2820

gcagcccttc ctcttcgtgc tctgggacca gcagcacaag ttccctgtct tcatggggcg     2880

agtatatgac cccagggcct gaagatctag agctgaattc ctgcagccag ggggatcagc     2940

ctctactgtg ccttctagtt gccagccatc tgttgtttgc ccctccccct tgccttcctt     3000

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcaca     3060

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3120

ggattgggaa gacaatagca ggcatgctgg ggatgcagtg ggctctatgg cttctgaggc     3180

agaaagaacc agctggggct cgagatccac tagggccgca ggaaccccta gtgatggagt     3240

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     3300

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 3349


<210>  16
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SYN4.SERPING1_BGH228

<400>  16
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatgaagtg ggtgaccctg ctgaccctgc tgctgctgct     1440

gctgttcctg tggagcagct gcagggccaa tccaaatgct accagctcca gctcccagga     1500

tccagagagt ttgcaagaca gaggcgaagg gaaggtcgca acaacagtta tctccaagat     1560

gctattcgtt gaacccatcc tggaggtttc cagcttgccg acaaccaact caacaaccaa     1620

ttcagccacc aaaataacag ctaataccac tgatgaaccc accacacaac ccaccacaga     1680

gcccaccacc caacccacca tccaacccac ccaaccaact acccagctcc caacagattc     1740

tcctacccag cccactactg ggtccttctg cccaggacct gttactctct gctctgactt     1800

ggagagtcat tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct     1860

ctaccacgcc ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag     1920

catcgccagc ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct     1980

ggagagcatc ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacgaccaaa ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag     2100

ggacaccttt gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa     2160

caacagtgac gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagccgg ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat     2280

ctacctgagt gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt     2340

tcacttcaaa aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc     2400

ccatttcatt gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct     2460

gagtttggtg atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc     2520

tctcagccct tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc     2580

cactctccta acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat     2640

ggagaaattg gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga     2700

ccctgatctt caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaggcg gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt     2820

gcagcagccc ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg     2880

gcgagtatat gaccccaggg cctgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  17
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coI2_BGH228

<400>  17
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggctag cagactgact ctgctgaccc tgctgctgct     1440

gctgctggct ggggacaggg ccagcagcaa ccctaatgct acctctagct ctagccagga     1500

ccctgagagc ctgcaggata ggggggaggg caaggtggcc accactgtga tcagcaagat     1560

gctgtttgtg gagcctatcc tggaggtgag cagcctgccc accaccaact ctactaccaa     1620

ctctgctacc aagatcactg ccaataccac tgatgaaccc accactcagc ccactactga     1680

gcccaccacc cagcccacca ttcagcccac tcagcccact acccagctgc ctactgactc     1740

tcccacccag cccaccactg gcagcttttg tcctggccct gtgaccctgt gctctgacct     1800

ggagagccat tctactgagg ctgtgctggg ggatgccctg gtggacttca gcctgaagct     1860

gtaccatgcc ttctctgcca tgaagaaggt ggagaccaac atggccttca gccccttctc     1920

tattgcctct ctgctgaccc aggtgctgct gggggctggg gagaatacta agaccaacct     1980

ggagagcatt ctgagctatc ccaaggactt cacctgtgtg caccaggccc tgaaggggtt     2040

cactactaaa ggggtgacct ctgtgtctca gatcttccac agccctgacc tggccatcag     2100

ggacactttt gtgaatgcca gcaggaccct gtacagcagc agccccagag tgctgagcaa     2160

taattctgat gctaatctgg agctgattaa cacttgggtg gccaagaaca ccaacaacaa     2220

gatctctagg ctgctggatt ctctgccctc tgacaccagg ctggtgctgc tgaatgccat     2280

ctatctgtct gccaagtgga agaccacctt tgatcccaag aagaccagga tggagccctt     2340

ccatttcaag aactctgtga ttaaagtgcc catgatgaac tctaagaagt atcctgtggc     2400

ccacttcatt gatcagactc tgaaggccaa ggtggggcag ctgcagctga gccacaacct     2460

gagcctggtg atcctggtgc cccagaatct gaagcacagg ctggaggaca tggagcaggc     2520

cctgagcccc tctgtgttca aggccatcat ggagaagctg gagatgagca agttccagcc     2580

caccctgctg actctgccca gaattaaggt gaccaccagc caggacatgc tgagcatcat     2640

ggagaagctg gagttctttg acttctctta tgacctgaac ctgtgtggcc tgactgagga     2700

tcctgacctg caggtgtctg ccatgcagca ccagactgtg ctggagctga ctgagactgg     2760

ggtggaggct gctgctgcct ctgccatttc tgtggccagg accctgctgg tgtttgaggt     2820

gcagcagccc ttcctgtttg tgctgtggga ccagcagcac aagtttcctg tgtttatggg     2880

cagggtgtat gaccctaggg cctgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  18
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coI3_BGH228

<400>  18
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggccag caggctgacc ctgctgactc tgctgctgct     1440

gctgctggct ggggacaggg ccagcagcaa ccctaatgcc acctccagca gcagccagga     1500

ccctgagagc ctgcaggata ggggggaggg caaggtggct actactgtga tcagcaagat     1560

gctgtttgtg gagcctatcc tggaggtgag cagcctgccc accactaact ctactactaa     1620

ttctgccact aagatcactg ccaataccac tgatgagcca accactcagc ccaccactga     1680

gcccaccacc cagcccacca ttcagcccac tcagcctacc acccagctgc ctactgacag     1740

ccccactcag cccactactg gctctttctg tcctgggcct gtgactctgt gctctgacct     1800

ggaatcccac agcactgagg ctgtgctggg ggatgccctg gtggatttca gcctgaagct     1860

gtaccatgct ttctctgcca tgaagaaggt ggagaccaac atggccttca gccctttctc     1920

tattgccagc ctgctgactc aggtgctgct gggggctggg gagaatacca agaccaacct     1980

ggagtctatc ctgagctatc ccaaggactt cacttgtgtg caccaggccc tgaaggggtt     2040

caccaccaag ggggtgacct ctgtgtctca gatctttcac agccctgacc tggccatcag     2100

ggataccttt gtgaatgcca gcaggaccct gtacagcagc agccccaggg tgctgagcaa     2160

caactctgat gccaacctgg agctgatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagcagg ctgctggaca gcctgccctc tgataccagg ctggtgctgc tgaatgccat     2280

ctacctgtct gctaagtgga agaccacttt tgatcctaag aagaccagga tggagccctt     2340

tcacttcaag aactctgtga tcaaggtgcc catgatgaac tctaagaaat accctgtggc     2400

ccacttcatt gatcagaccc tgaaggccaa ggtgggccag ctgcagctga gccacaacct     2460

gagcttggtg atcctggtgc ctcagaacct gaagcacagg ctggaggaca tggagcaggc     2520

cctgagcccc tctgtgttca aggccattat ggagaagctg gagatgagca agttccagcc     2580

taccctgctg accctgccca ggatcaaggt gactactagc caggatatgc tgagcatcat     2640

ggagaagctg gagttttttg atttcagcta tgacctgaac ctgtgtggcc tgactgagga     2700

ccctgacctg caggtgtctg ccatgcagca tcagactgtg ctggagctga ctgagactgg     2760

ggtggaggct gctgctgcct ctgccatctc tgtggccagg accctgctgg tgtttgaggt     2820

gcagcagcct ttcctgtttg tgctgtggga tcagcagcac aagtttcctg tgttcatggg     2880

cagggtgtat gaccccaggg cttgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  19
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coI4_BGH228

<400>  19
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggctag cagactgact ctgctgaccc tgctgctgct     1440

gctgctggct ggggacaggg ccagcagcaa ccctaatgct acctctagct ctagccagga     1500

ccctgagagc ctgcaggata ggggggaggg caaggtggcc accactgtga tcagcaagat     1560

gctgtttgtg gagcctatcc tggaggtgag cagcctgccc accaccaact ctactaccaa     1620

ctctgctacc aagatcactg ccaataccac tgatgaaccc accactcagc ccactactga     1680

gcccaccacc cagcccacca ttcagcccac tcagcccact acccagctgc ctactgactc     1740

tcccacccag cccaccactg ggagcttctg tccaggccct gtgactctgt gttctgacct     1800

ggagagccac agcactgaag ctgtgctggg ggatgctctg gtggacttca gcctgaagct     1860

gtaccatgcc ttctctgcca tgaagaaggt ggaaaccaac atggccttta gccccttcag     1920

cattgctagc ctgctgactc aggtgctgct gggggctggg gagaacacta agactaacct     1980

ggagtctatc ctgtcttatc ccaaggactt cacctgtgtg catcaggccc tgaaggggtt     2040

caccaccaag ggggtcacct ctgtgagcca gatctttcac agccctgatc tggccatcag     2100

ggacaccttt gtgaatgcct ctaggactct gtacagcagc agccccaggg tgctgagcaa     2160

caactctgat gccaacctgg agctgatcaa cacctgggtg gccaagaaca ctaacaacaa     2220

gatcagcagg ctgctggaca gcctgccctc tgacactagg ctggtgctgc tgaatgccat     2280

ctatctgtct gccaagtgga agaccacctt tgaccccaag aagactagga tggagccctt     2340

tcattttaag aactctgtga tcaaggtgcc catgatgaac agcaagaaat accctgtggc     2400

ccatttcatt gaccagactc tgaaggctaa ggtgggccag ctgcagctga gccacaacct     2460

gagcctggtg atcctggtgc cacagaatct gaagcacagg ctggaggaca tggagcaggc     2520

tctgtctccc tctgtgttca aggccatcat ggagaagctg gagatgtcta agttccagcc     2580

caccctgctg accctgccca ggatcaaggt gaccacttct caggacatgc tgtctatcat     2640

ggagaagctg gagttttttg acttttctta tgacctgaac ctgtgtggcc tgactgagga     2700

ccctgatctg caggtgtctg ccatgcagca ccagactgtg ctggagctga ctgagactgg     2760

ggtggaggct gctgctgctt ctgccatttc tgtggctagg actctgctgg tgtttgaggt     2820

gcagcagccc ttcctgtttg tgctgtggga ccagcagcac aagttccctg tgttcatggg     2880

cagggtgtat gatcccaggg cttgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  20
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coI7_BGH228

<400>  20
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggctag cagactgact ctgctgaccc tgctgctgct     1440

gctgctggct ggggacaggg ccagcagcaa ccctaatgct acctctagct ctagccagga     1500

ccctgagagc ctgcaggata ggggggaggg caaggtggcc accactgtga tcagcaagat     1560

gctgtttgtg gagcctatcc tggaggtgag cagcctgccc accaccaact ctactaccaa     1620

ctctgctacc aagatcactg ccaataccac tgatgaaccc accactcagc ccactactga     1680

gcccaccacc cagcccacca ttcagcccac tcagcccact acccagctgc ctactgactc     1740

tcccacccag cccaccactg gcagcttctg ccctgggcct gtgaccctgt gctctgacct     1800

ggagagccat tctactgagg ctgtgctggg ggatgccctg gtggatttca gcctgaagct     1860

gtaccatgcc ttctctgcca tgaagaaggt ggagaccaac atggccttct ctcccttcag     1920

cattgccagc ctgctgaccc aggtgctgct gggggctggg gagaacacca agaccaacct     1980

ggagagcatc ctgtcttacc ccaaggactt cacctgtgtg catcaggccc tgaagggctt     2040

cactactaag ggggtgacct ctgtgtctca gattttccac agccctgacc tggctattag     2100

ggacactttt gtgaatgctt ctaggaccct gtacagcagc tctcccaggg tgctgagcaa     2160

caactctgat gccaacctgg agctgattaa cacttgggtg gccaagaaca ctaacaataa     2220

gatcagcagg ctgctggaca gcctgccctc tgacaccagg ctggtgctgc tgaatgccat     2280

ctacctgtct gccaagtgga agactacttt tgatcctaag aagaccagga tggagccttt     2340

ccacttcaag aactctgtga tcaaggtgcc catgatgaat tctaagaagt accctgtggc     2400

tcacttcatt gaccagaccc tgaaggccaa ggtgggccag ctgcagctga gccacaacct     2460

gagcctggtg attctggtgc cccagaacct gaagcacagg ctggaggaca tggagcaggc     2520

cctgagcccc tctgtgttca aggccatcat ggagaagctg gagatgagca agttccagcc     2580

tactctgctg actctgccca ggatcaaggt gaccactagc caggacatgc tgagcattat     2640

ggagaagctg gagttctttg acttttctta tgatctgaac ctgtgtggcc tgactgagga     2700

ccctgacctg caggtgtctg ccatgcagca ccagactgtg ctggagctga ctgagactgg     2760

ggtggaggct gctgctgcct ctgccatctc tgtggctagg accctgctgg tgtttgaggt     2820

gcagcagccc ttcctgtttg tgctgtggga ccagcagcac aagttccctg tcttcatggg     2880

cagggtgtat gatcccaggg cttgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  21
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coI20_BGH228

<400>  21
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggccag caggctgacc ctgctgaccc tgctgctgct     1440

cctgctggct ggggataggg ccagcagcaa ccccaatgct actagcagca gcagccagga     1500

tcctgagagc ctgcaggaca gaggggaagg gaaggtggcc accactgtga tcagcaagat     1560

gctgtttgtg gagcctatcc tggaggtgag ctctctgccc accactaaca gcaccaccaa     1620

ttctgctact aagatcactg ccaacaccac tgatgagccc accacccagc ctaccactga     1680

gccaactacc cagcccacca tccagcccac ccagcccacc actcagctgc ctactgattc     1740

tcctactcag cctaccactg ggagcttctg ccctgggcct gtgaccctgt gctctgacct     1800

ggagtctcat tctactgagg ctgtgctggg ggatgccctg gtggacttca gcctgaagct     1860

gtaccatgct ttctctgcca tgaagaaggt ggagactaac atggccttct ctcctttctc     1920

tattgccagc ctgctgactc aggtgctgct gggggctggg gagaatacca agactaacct     1980

ggagagcatc ctgtcttatc ctaaggactt cacttgtgtg catcaggccc tgaagggctt     2040

caccaccaag ggggtgactt ctgtgagcca gattttccac agccctgacc tggccatcag     2100

agacaccttt gtgaatgcca gcaggaccct gtattctagc tctcccaggg tgctgagcaa     2160

caactctgat gccaatctgg aactgatcaa cacttgggtg gccaagaaca ccaacaacaa     2220

gatcagcagg ctgctggata gcctgccctc tgacaccagg ctggtgctgc tgaatgccat     2280

ctacctgtct gccaagtgga agaccacctt tgaccccaag aagactagga tggagccctt     2340

ccacttcaag aactctgtga tcaaggtgcc catgatgaat agcaagaagt accctgtggc     2400

ccacttcatt gaccagaccc tgaaggccaa ggtggggcag ctgcagctga gccacaacct     2460

gagcctggtg atcctggtgc cccagaacct gaagcacaga ctggaggaca tggagcaggc     2520

cctgagccca tctgtgttca aggctattat ggagaagctg gagatgtcta agtttcagcc     2580

taccctgctg accctgccca ggatcaaggt gactaccagc caggacatgc tgagcatcat     2640

ggagaagctg gaattctttg acttcagcta tgatctgaat ctgtgtggcc tgactgaaga     2700

ccctgatttg caggtgtctg ctatgcagca ccagactgtg ctggaactga ctgagactgg     2760

ggtggaggct gctgctgcct ctgccatctc tgtggccagg accctgctgg tgtttgaggt     2820

gcagcagcct ttcctgtttg tgctgtggga tcagcagcac aagttccctg tgttcatggg     2880

cagggtgtat gaccctaggg cttgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  22
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1co21_BGH228

<400>  22
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc taggctgact ctgctgactc tgctgctcct     1440

gctgctggct ggggacaggg ccagctctaa ccccaatgct acttctagct cctctcagga     1500

ccctgagagc ctgcaggaca ggggggaggg caaggtggcc accactgtga tctctaagat     1560

gctgtttgtg gagcccatcc tggaggtgag cagcctgccc accaccaaca gcaccaccaa     1620

ctctgccact aagatcactg ccaacaccac tgatgagccc accacccagc ccactactga     1680

gcccaccacc cagcctacta tccagcccac ccagcccact acccagctgc ccactgacag     1740

ccctacccag cccaccactg gcagcttctg ccctgggcct gtgaccctgt gctctgacct     1800

ggagagccat tctactgagg ctgtgctggg ggatgccctg gtggacttct ctctgaagct     1860

gtaccatgct ttctctgcca tgaagaaggt ggagactaac atggctttta gccccttcag     1920

cattgctagc ctgctgaccc aggtgctgct gggggctggg gagaacacta agaccaacct     1980

ggaatctatc ctgagctacc ccaaggactt cacctgtgtg caccaggccc tgaagggctt     2040

caccaccaag ggggtgacct ctgtgagcca gatcttccac agccctgacc tggccatcag     2100

ggatactttt gtgaatgcca gcagaaccct gtactcttct agccccaggg tgctgagcaa     2160

taattctgat gctaacctgg agctgatcaa tacctgggtg gctaagaata ccaacaacaa     2220

gattagcagg ctgctggact ctctgccttc tgataccagg ctggtgctgc tgaatgccat     2280

ttacctgtct gccaagtgga agaccacttt tgaccctaag aagactagga tggagccttt     2340

ccacttcaag aactctgtca ttaaggtgcc catgatgaac agcaagaagt atcctgtggc     2400

ccactttatt gaccagactc tgaaggccaa ggtgggccag ctgcagctga gccataacct     2460

gagcctggtg atcctggtgc cccagaacct gaagcatagg ctggaggaca tggagcaggc     2520

tctgagcccc tctgtgttca aggctattat ggagaagctg gagatgagca agttccagcc     2580

cactctgctg accctgccca gaatcaaggt gaccacctct caggacatgc tgagcatcat     2640

ggaaaagctg gagttctttg acttttctta tgacctgaat ctgtgtggcc tgactgagga     2700

tcctgatctg caggtgtctg ccatgcagca ccagactgtg ctggagctga ctgagactgg     2760

ggtggaggct gctgctgctt ctgccatctc tgtggccagg accctgctgg tgtttgaggt     2820

gcagcagccc ttcctgtttg tgctgtggga ccagcagcac aagtttcctg tgttcatggg     2880

cagggtgtat gaccccagag cctgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  23
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coI24_BGH228

<400>  23
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggctag caggctgacc ctgctgaccc tgctgctcct     1440

gctgctggct ggggacaggg cctctagcaa tcccaatgcc acctctagct ctagccagga     1500

tcctgagagc ctgcaggaca ggggggaggg caaggtggcc accactgtga tcagcaagat     1560

gctgtttgtg gagcccattc tggaggtgtc ttctctgccc accaccaata gcaccactaa     1620

ttctgccacc aagatcactg ctaacaccac tgatgagccc accactcagc ctaccactga     1680

gcccaccacc cagcccacta tccagcccac ccagcccacc acccagctgc ctactgacag     1740

ccctacccag cccactactg ggagcttctg ccctggccct gtgaccctgt gctctgacct     1800

ggagagccac agcactgagg ctgtgctggg ggatgccctg gtggacttca gcctgaagct     1860

gtaccatgcc ttttctgcca tgaagaaggt ggagaccaac atggccttta gccctttcag     1920

cattgccagc ctgctgactc aggtgctgct gggggctggg gagaacacca agaccaacct     1980

ggagagcatc ctgagctacc ccaaggactt cacttgtgtg caccaggccc tgaagggctt     2040

cactaccaag ggggtgactt ctgtgagcca gatcttccac agccctgacc tggccatcag     2100

ggatactttt gtgaatgcca gcaggaccct gtacagcagc agccccaggg tgctgagcaa     2160

caactctgat gctaacctgg agctgatcaa tacttgggtg gccaagaaca ccaacaacaa     2220

gatttctagg ctgctggact ctctgccctc tgacactagg ctggtgctgc tgaatgccat     2280

ctacctgtct gccaagtgga agaccacctt tgatcccaag aagactagga tggagccctt     2340

ccacttcaag aactctgtga tcaaggtgcc catgatgaac agcaagaagt accctgtggc     2400

ccatttcatt gaccagaccc tgaaggccaa ggtggggcag ctgcagctga gccacaatct     2460

gagcctggtg attctggtgc cccagaatct gaagcacaga ctggaggaca tggagcaggc     2520

tctgtctccc tctgtgttca aggccatcat ggagaagctg gagatgagca agttccagcc     2580

cactctgctg actctgccta ggatcaaggt gaccaccagc caggacatgc tgagcattat     2640

ggagaagctg gagttctttg acttcagcta tgacctgaac ctgtgtggcc tgactgagga     2700

ccctgatctg caggtgtctg ccatgcagca ccagactgtg ctggagctga ctgagactgg     2760

ggtggaggct gctgctgcct ctgctatttc tgtggccagg accctgctgg tgtttgaggt     2820

gcagcagccc ttcctgtttg tgctgtggga ccagcagcac aagtttcctg tgttcatggg     2880

gagggtgtat gaccccaggg cctgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  24
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coH9_BGH228

<400>  24
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

cctgctggct ggggatagag cctctagcaa tccaaatgct accagctcct cctcccagga     1500

tcctgaatcc cttcaagaca ggggggaggg caaggtggca actactgtga tttccaagat     1560

gctgtttgtg gagcccatcc tggaggttag cagccttcct actaccaact caacaaccaa     1620

ttcagccacc aaaattacag ctaataccac agatgagcca acaactcaac ccaccactga     1680

gcccaccact cagccaacca tccaacccac ccaaccaact acccagctcc caacagattc     1740

tcctacccag cctaccactg gctccttctg cccaggacct gttactctct gctctgactt     1800

ggaaagccat tctactgagg ctgtcctggg ggatgctttg gtagacttct ccctgaagct     1860

ctaccatgca ttttcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag     1920

tatagcaagt ctcctgactc aggtcctgct gggggcaggg gagaatacaa agaccaacct     1980

ggagagcatc ctcagttatc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacaacaaag ggggtgacct cagtctctca gattttccac agcccagacc tggccataag     2100

ggacaccttt gtgaatgcct ctaggaccct gtactcaagc tcccccagag tcctaagcaa     2160

caacagtgat gcaaatttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagcagg ctgctagaca gtctgccaag tgatacaagg cttgtcctcc tcaatgctat     2280

ctacctgagt gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt     2340

tcacttcaaa aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc     2400

ccatttcatt gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct     2460

gagtctggta atcctggtac cccagaacct gaaacatagg cttgaagaca tggaacaggc     2520

tctcagccct tctgttttca aggccataat ggagaagctg gagatgtcca agttccagcc     2580

cactctccta acactaccca ggatcaaagt gacaaccagc caggatatgc tctcaatcat     2640

ggagaaattg gaattttttg atttttctta tgaccttaac ctgtgtgggc tgacagagga     2700

ccctgatctt caggtttctg caatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaagct gctgcagcaa gtgcaatatc tgtggccaga accctgctgg tctttgaagt     2820

gcagcagccc ttcctgtttg tgctgtggga ccagcagcac aagttccctg tcttcatggg     2880

gagggtatat gaccccaggg cctgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  25
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coH13_BGH228

<400>  25
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctcaccc tcctgctgct     1440

cctgctggct ggggacaggg cctccagcaa ccccaatgca accagcagtt cctctcagga     1500

tccagagtcc ctgcaggaca ggggggaggg caaggtggcc accactgtga tctccaagat     1560

gctgtttgtg gagcccatcc tggaggtatc cagcctccct accaccaaca gcaccaccaa     1620

ctcagccacc aaaatcactg ctaacaccac tgatgagccc acaacccagc caactactga     1680

gccaaccact cagcctacca tccaacccac ccagcctact acccagctcc ccactgactc     1740

tcctacccag cccaccactg gcagcttctg cccaggacct gtgaccctct gctctgactt     1800

ggagtcccat tccacagagg cagtgctggg ggatgccctg gtagacttct ccctgaagct     1860

ctaccatgca ttctctgcca tgaagaaggt ggagaccaac atggccttct cccccttcag     1920

cattgccagc ctcctgaccc aggtcctgct gggggcaggg gagaacacaa agacaaacct     1980

ggagtccatc ctcagctacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacaaccaag ggggtgacca gtgtctcaca gattttccac agcccagacc tggccatcag     2100

ggacaccttt gtgaatgcca gtaggaccct gtacagctcc agtcccagag tcctcagcaa     2160

caactctgat gccaacctgg agctgatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagcagg ctgctagact cactgccctc tgacacaagg ctggtcctcc tcaatgcaat     2280

ctacctgagt gccaagtgga agaccacctt tgaccccaag aagaccagga tggagccctt     2340

ccacttcaag aacagtgtca ttaaggtgcc catgatgaac agcaagaagt accctgtggc     2400

ccacttcatt gaccagacct tgaaggccaa ggtggggcag ctgcagctct cccacaacct     2460

gtcactggtc atcctggttc cccagaacct gaagcacagg cttgaggaca tggagcaggc     2520

cctcagccct tctgtattca aggccataat ggagaagctg gagatgagca agttccagcc     2580

cactctgctg accctaccca ggatcaaggt gaccaccagc caggacatgc tctcaatcat     2640

ggagaagttg gagttctttg acttcagcta tgacctgaac ctgtgtgggc tgacagagga     2700

ccctgacctg caggtgtcag ccatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaagct gctgcagcaa gtgctatttc agtggccagg accctgctgg tctttgaggt     2820

ccagcagccc ttcctgtttg tgctctggga ccagcagcac aagttccctg tcttcatggg     2880

gagggtctat gaccccaggg cctgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  26
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coBC2_BGH228

<400>  26
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

cctgctggct ggggacagag ccagcagcaa ccccaatgcc accagctcca gctctcagga     1500

cccagagagc ctgcaggaca ggggggaggg caaggtggcc accacagtga tcagcaagat     1560

gctgtttgtg gagcccatcc tggaggtgag cagcctcccc accaccaaca gcaccaccaa     1620

ttctgccacc aagatcacag ccaacaccac agatgagccc acaacccagc ctaccacaga     1680

gccaaccaca cagcccacca tccaacccac ccaacctact acccagctgc ccacagacag     1740

ccctacccag cctaccacag gcagcttctg ccctggccct gtgaccctgt gctctgactt     1800

ggagagccac tccacagagg ctgtgctggg ggatgccctg gtggatttca gcctgaagct     1860

gtaccatgcc ttctctgcca tgaagaaggt ggagaccaac atggccttca gccccttcag     1920

cattgccagc ctcctgaccc aggtcctgct gggggctggg gagaacacaa agaccaacct     1980

ggagagcatc ctgagctacc ccaaggactt cacctgtgtg caccaggccc tgaagggctt     2040

caccaccaag ggggtgacct ctgtgagcca gattttccac agccctgacc tggccatcag     2100

ggacaccttt gtgaatgcct ccaggaccct gtacagctct agccccaggg tgctgagcaa     2160

caactctgat gccaacttgg agctgatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagcagg ctgctggaca gcctgccctc tgacaccagg ctggtgctcc tgaatgccat     2280

ctacctgtct gccaagtgga agaccacctt tgaccccaag aagaccagaa tggagccctt     2340

ccacttcaag aactctgtga taaaggtgcc catgatgaac agcaagaagt accctgtggc     2400

ccacttcatt gaccagaccc tgaaagccaa ggtgggccag ctgcagctca gccacaacct     2460

gagcctggtc atcctggtgc cccagaacct gaagcacagg ctggaggaca tggaacaggc     2520

cctcagcccc tctgtgttca aggccattat ggagaagctg gagatgagca agttccagcc     2580

cactctgctg acactgccca ggatcaaggt gaccaccagc caggacatgc tgagcatcat     2640

ggagaagttg gagttctttg acttcagcta tgacctgaac ctgtgtggcc tgacagagga     2700

ccctgacctc caggtgtctg ccatgcagca ccagacagtg ctggaactga cagagacagg     2760

ggtggaagct gctgctgcct ctgccatctc tgtggccaga accctgctgg tgtttgaggt     2820

gcagcagccc ttcctgtttg tgctgtggga ccagcagcac aagttccctg tgttcatggg     2880

cagggtgtat gaccccaggg cctgaagatc tagagctgaa ttcctgcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  27
<211>  3352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1coI21(-RIDD)_BGH228

<400>  27
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc taggctgact ctgctgactc tgctgctcct     1440

gctgctggct ggggacaggg ccagctctaa ccccaatgct acttctagct cctctcagga     1500

ccctgagagc cttcaggaca ggggggaggg caaggtggcc accactgtga tctctaagat     1560

gctgtttgtg gagcccatcc tggaggtgag cagcctgccc accaccaaca gcaccaccaa     1620

ctctgccact aagatcactg ccaacaccac tgatgagccc accacccagc ccactactga     1680

gcccaccacc cagcctacta tccagcccac ccagcccact acccagctgc ccactgacag     1740

ccctacccag cccaccactg gcagcttctg ccctgggcct gtgaccctgt gctctgacct     1800

ggagagccat tctactgagg ctgtgctggg ggatgccctg gtggacttct ctctgaagct     1860

gtaccatgct ttctctgcca tgaagaaggt ggagactaac atggctttta gccccttcag     1920

cattgctagc ctgctgaccc aggtgctgct gggggctggg gagaacacta agaccaacct     1980

ggaatctatc ctgagctacc ccaaggactt cacctgtgtg caccaggccc tgaagggctt     2040

caccaccaag ggggtgacct ctgtgagcca gatcttccac agccctgacc tggccatcag     2100

ggatactttt gtgaatgcca gcagaaccct gtactcttct agccccaggg tgctgagcaa     2160

taattctgat gctaacctgg agctgatcaa tacctgggtg gctaagaata ccaacaacaa     2220

gattagcagg ctgctggact ctctgccttc tgataccagg ctggtgctgc tgaatgccat     2280

ttacctgtct gccaagtgga agaccacttt tgaccctaag aagactagga tggagccttt     2340

ccacttcaag aactctgtca ttaaggtgcc catgatgaac agcaagaagt atcctgtggc     2400

ccactttatt gaccagactc tgaaggccaa ggtgggccag cttcagctga gccataacct     2460

gagcctggtg atcctggtgc cccagaacct gaagcatagg ctggaggaca tggagcaggc     2520

tctgagcccc tctgtgttca aggctattat ggagaagctg gagatgagca agttccagcc     2580

cactctgctg accctgccca gaatcaaggt gaccacctct caggacatgc tgagcatcat     2640

ggaaaagctg gagttctttg acttttctta tgacctgaat ctgtgtggcc tgactgagga     2700

tcctgatctt caggtgtctg ccatgcagca ccagactgtg ctggagctga ctgagactgg     2760

ggtggaggct gctgctgctt ctgccatctc tgtggccagg accctgctgg tgtttgaggt     2820

gcagcagccc ttcctgtttg tgctgtggga ccagcagcac aagtttcctg tgttcatggg     2880

cagggtgtat gaccccagag cctgaagatc tagagctgaa ttccttcagc cagggggatc     2940

agcctctact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccttgccttc     3000

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3060

acattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     3120

ggaggattgg gaagacaata gcaggcatgc tggggatgca gtgggctcta tggcttctga     3180

ggcagaaaga accagctggg gctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3240

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     3300

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             3352


<210>  28
<211>  3354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1coI21_BGH228

<400>  28
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca ctaagaccaa     1980

cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg ccctgaaggg     2040

cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca gggtgctgag     2160

caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga ataccaacaa     2220

caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc tgctgaatgc     2280

catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta ggatggagcc     2340

tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga agtatcctgt     2400

ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc tgagccataa     2460

cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg acatggagca     2520

ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat     2640

catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg gcctgactga     2700

ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

gggcagggtg tatgacccca gagcctgaca tctagagctg aattcctgca gccaggggga     2940

tcagcctcta ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccttgcct     3000

tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca     3060

tcacattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag     3120

ggggaggatt gggaagacaa tagcaggcat gctggggatg cagtgggctc tatggcttct     3180

gaggcagaaa gaaccagctg gggctcgaga tccactaggg ccgcaggaac ccctagtgat     3240

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     3300

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag           3354


<210>  29
<211>  3354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1coI24_BGH228

<400>  29
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc tagcaggctg accctgctga ccctgctgct     1440

cctgctgctg gctggggaca gggcctctag caatcccaat gccacctcta gctctagcca     1500

ggatcctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatcagcaa     1560

gatgctgttt gtggagccca ttctggaggt gtcttctctg cccaccacca atagcaccac     1620

taattctgcc accaagatca ctgctaacac cactgatgag cccaccactc agcctaccac     1680

tgagcccacc acccagccca ctatccagcc cacccagccc accacccagc tgcctactga     1740

cagccctacc cagcccacta ctgggagctt ctgccctggc cctgtgaccc tgtgctctga     1800

cctggagagc cacagcactg aggctgtgct gggggatgcc ctggtggact tcagcctgaa     1860

gctgtaccat gccttttctg ccatgaagaa ggtggagacc aacatggcct ttagcccttt     1920

cagcattgcc agcctgctga ctcaggtgct gctgggggct ggggagaaca ccaagaccaa     1980

cctggagagc atcctgagct accccaagga cttcacttgt gtgcaccagg ccctgaaggg     2040

cttcactacc aagggggtga cttctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcaggac cctgtacagc agcagcccca gggtgctgag     2160

caacaactct gatgctaacc tggagctgat caatacttgg gtggccaaga acaccaacaa     2220

caagatttct aggctgctgg actctctgcc ctctgacact aggctggtgc tgctgaatgc     2280

catctacctg tctgccaagt ggaagaccac ctttgatccc aagaagacta ggatggagcc     2340

cttccacttc aagaactctg tgatcaaggt gcccatgatg aacagcaaga agtaccctgt     2400

ggcccatttc attgaccaga ccctgaaggc caaggtgggg cagctgcagc tgagccacaa     2460

tctgagcctg gtgattctgg tgccccagaa tctgaagcac agactggagg acatggagca     2520

ggctctgtct ccctctgtgt tcaaggccat catggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgactctgc ctaggatcaa ggtgaccacc agccaggaca tgctgagcat     2640

tatggagaag ctggagttct ttgacttcag ctatgacctg aacctgtgtg gcctgactga     2700

ggaccctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cctctgctat ttctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

ggggagggtg tatgacccca gggcctgaca tctagagctg aattcctgca gccaggggga     2940

tcagcctcta ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccttgcct     3000

tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca     3060

tcacattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag     3120

ggggaggatt gggaagacaa tagcaggcat gctggggatg cagtgggctc tatggcttct     3180

gaggcagaaa gaaccagctg gggctcgaga tccactaggg ccgcaggaac ccctagtgat     3240

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     3300

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag           3354


<210>  30
<211>  3130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_ ?76.SERPING1_BGH228

<400>  30
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

gctgctggct ggggatagag cctcctcaaa tcccaccatc caacccaccc aaccaactac     1500

ccagctccca acagattctc ctacccagcc cactactggg tccttctgcc caggacctgt     1560

tactctctgc tctgacttgg agagtcattc aacagaggcc gtgttggggg atgctttggt     1620

agatttctcc ctgaagctct accacgcctt ctcagcaatg aagaaggtgg agaccaacat     1680

ggccttttcc ccattcagca tcgccagcct ccttacccag gtcctgctcg gggctgggga     1740

gaacaccaaa acaaacctgg agagcatcct ctcttacccc aaggacttca cctgtgtcca     1800

ccaggccctg aagggcttca cgaccaaagg tgtcacctca gtctctcaga ttttccacag     1860

cccagacctg gccataaggg acacctttgt gaatgcctct cggaccctgt acagcagcag     1920

ccccagagtc ctaagcaaca acagtgacgc caacttggag ctcatcaaca cctgggtggc     1980

caagaacacc aacaacaaga tcagccggct gctagacagt ctgccctccg atacccgcct     2040

tgtcctcctc aatgctatct acctgagtgc caagtggaag acaacatttg atcccaagaa     2100

aaccagaatg gaaccctttc acttcaaaaa ctcagttata aaagtgccca tgatgaatag     2160

caagaagtac cctgtggccc atttcattga ccaaactttg aaagccaagg tggggcagct     2220

gcagctctcc cacaatctga gtttggtgat cctggtaccc cagaacctga aacatcgtct     2280

tgaagacatg gaacaggctc tcagcccttc tgttttcaag gccatcatgg agaaactgga     2340

gatgtccaag ttccagccca ctctcctaac actaccccgc atcaaagtga cgaccagcca     2400

ggatatgctc tcaatcatgg agaaattgga attcttcgat ttttcttatg accttaacct     2460

gtgtgggctg acagaggacc ctgatcttca ggtttctgcg atgcagcacc agacagtgct     2520

ggaactgaca gagactgggg tggaggcggc tgcagcctcc gccatctctg tggcccgcac     2580

cctgctggtc tttgaagtgc agcagccctt cctcttcgtg ctctgggacc agcagcacaa     2640

gttccctgtc ttcatggggc gagtatatga ccccagggcc tgaagatcta gagctgaatt     2700

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     2760

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2820

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     2880

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     2940

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     3000

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     3060

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     3120

gagcgcgcag                                                            3130


<210>  31
<211>  3064
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   AAV_ApoE_hAAT_HBB2m1_ ?98.SERPING1_BGH228

<400>  31
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

gctgctggct ggggatagag cctcctcaaa tgggtccttc tgcccaggac ctgttactct     1500

ctgctctgac ttggagagtc attcaacaga ggccgtgttg ggggatgctt tggtagattt     1560

ctccctgaag ctctaccacg ccttctcagc aatgaagaag gtggagacca acatggcctt     1620

ttccccattc agcatcgcca gcctccttac ccaggtcctg ctcggggctg gggagaacac     1680

caaaacaaac ctggagagca tcctctctta ccccaaggac ttcacctgtg tccaccaggc     1740

cctgaagggc ttcacgacca aaggtgtcac ctcagtctct cagattttcc acagcccaga     1800

cctggccata agggacacct ttgtgaatgc ctctcggacc ctgtacagca gcagccccag     1860

agtcctaagc aacaacagtg acgccaactt ggagctcatc aacacctggg tggccaagaa     1920

caccaacaac aagatcagcc ggctgctaga cagtctgccc tccgataccc gccttgtcct     1980

cctcaatgct atctacctga gtgccaagtg gaagacaaca tttgatccca agaaaaccag     2040

aatggaaccc tttcacttca aaaactcagt tataaaagtg cccatgatga atagcaagaa     2100

gtaccctgtg gcccatttca ttgaccaaac tttgaaagcc aaggtggggc agctgcagct     2160

ctcccacaat ctgagtttgg tgatcctggt accccagaac ctgaaacatc gtcttgaaga     2220

catggaacag gctctcagcc cttctgtttt caaggccatc atggagaaac tggagatgtc     2280

caagttccag cccactctcc taacactacc ccgcatcaaa gtgacgacca gccaggatat     2340

gctctcaatc atggagaaat tggaattctt cgatttttct tatgacctta acctgtgtgg     2400

gctgacagag gaccctgatc ttcaggtttc tgcgatgcag caccagacag tgctggaact     2460

gacagagact ggggtggagg cggctgcagc ctccgccatc tctgtggccc gcaccctgct     2520

ggtctttgaa gtgcagcagc ccttcctctt cgtgctctgg gaccagcagc acaagttccc     2580

tgtcttcatg gggcgagtat atgaccccag ggcctgaaga tctagagctg aattcctgca     2640

gccaggggga tcagcctcta ctgtgccttc tagttgccag ccatctgttg tttgcccctc     2700

ccccttgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     2760

ggaaattgca tcacattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     2820

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cagtgggctc     2880

tatggcttct gaggcagaaa gaaccagctg gggctcgaga tccactaggg ccgcaggaac     2940

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     3000

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     3060

gcag                                                                  3064


<210>  32
<211>  3349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAATv18_HBB2m1_SERPING1coI21_BGH228

<400>  32
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cacttgaccc cttggaattt tggtggagag gagcagaggt tgtcctggtg      420

tggtttaggt agtgtgagag gggtacctgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cagccacccc ctccaccttg gacacaggat gctgtggttt ctgagccagg tacaatgact      600

cctttggtaa gtgcagtgga agctgtacac tgcccaggca aaggtctggg caggtagggg      660

gtgactcaga tcccagccag tggacttagc ccctgtttgc tcctctgata actggggtga      720

ccttggttaa tattcaccag cagcctcccc tgttgcccct ctggatccac tgcttaaata      780

tggatgagga cagggccctg tctcctcagc ttcaggcacc accactgacc tgggacagtg      840

aatagatctt gagaacttca gggtgagtct atgggaccct tgatgttttc tttccccttc      900

ttttctatgg ttaagttcat gtcataggaa ggggagaagt aacagggtac acatattgac      960

caaatcaggg taattttgca tttgtaattt taaaaaatgc tttcttcttt taatatactt     1020

ttttgtttat cttatttcta atactttccc taatctcttt ctttcagggc aataatgata     1080

caatgtatca tgcctctttg caccattcta aagaataaca gtgataattt ctgggttaag     1140

gcaatagcaa tatttctgca tataaatatt tctgcatata aattgtaact gatgtaagag     1200

gtttcatatt gctaatagca gctacaatcc agctaccatt ctgcttttat tttctggttg     1260

ggataaggct ggattattct gagtccaagc taggcccttt tgctaatctt gttcatacct     1320

cttatcttcc tcccacagct cctgggcaac ctgctggtct ctctgctggc ccatcacttt     1380

ggcaaagcac tagtgccacc atggcctcta ggctgactct gctgactctg ctgctcctgc     1440

tgctggctgg ggacagggcc agctctaacc ccaatgctac ttctagctcc tctcaggacc     1500

ctgagagcct gcaggacagg ggggagggca aggtggccac cactgtgatc tctaagatgc     1560

tgtttgtgga gcccatcctg gaggtgagca gcctgcccac caccaacagc accaccaact     1620

ctgccactaa gatcactgcc aacaccactg atgagcccac cacccagccc actactgagc     1680

ccaccaccca gcctactatc cagcccaccc agcccactac ccagctgccc actgacagcc     1740

ctacccagcc caccactggc agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg     1800

agagccattc tactgaggct gtgctggggg atgccctggt ggacttctct ctgaagctgt     1860

accatgcttt ctctgccatg aagaaggtgg agactaacat ggcttttagc cccttcagca     1920

ttgctagcct gctgacccag gtgctgctgg gggctgggga gaacactaag accaacctgg     1980

aatctatcct gagctacccc aaggacttca cctgtgtgca ccaggccctg aagggcttca     2040

ccaccaaggg ggtgacctct gtgagccaga tcttccacag ccctgacctg gccatcaggg     2100

atacttttgt gaatgccagc agaaccctgt actcttctag ccccagggtg ctgagcaata     2160

attctgatgc taacctggag ctgatcaata cctgggtggc taagaatacc aacaacaaga     2220

ttagcaggct gctggactct ctgccttctg ataccaggct ggtgctgctg aatgccattt     2280

acctgtctgc caagtggaag accacttttg accctaagaa gactaggatg gagcctttcc     2340

acttcaagaa ctctgtcatt aaggtgccca tgatgaacag caagaagtat cctgtggccc     2400

actttattga ccagactctg aaggccaagg tgggccagct gcagctgagc cataacctga     2460

gcctggtgat cctggtgccc cagaacctga agcataggct ggaggacatg gagcaggctc     2520

tgagcccctc tgtgttcaag gctattatgg agaagctgga gatgagcaag ttccagccca     2580

ctctgctgac cctgcccaga atcaaggtga ccacctctca ggacatgctg agcatcatgg     2640

aaaagctgga gttctttgac ttttcttatg acctgaatct gtgtggcctg actgaggatc     2700

ctgatctgca ggtgtctgcc atgcagcacc agactgtgct ggagctgact gagactgggg     2760

tggaggctgc tgctgcttct gccatctctg tggccaggac cctgctggtg tttgaggtgc     2820

agcagccctt cctgtttgtg ctgtgggacc agcagcacaa gtttcctgtg ttcatgggca     2880

gggtgtatga ccccagagcc tgacatctag agctgaattc ctgcagccag ggggatcagc     2940

ctctactgtg ccttctagtt gccagccatc tgttgtttgc ccctccccct tgccttcctt     3000

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcaca     3060

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3120

ggattgggaa gacaatagca ggcatgctgg ggatgcagtg ggctctatgg cttctgaggc     3180

agaaagaacc agctggggct cgagatccac tagggccgca ggaaccccta gtgatggagt     3240

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     3300

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 3349


<210>  33
<211>  3349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAATv18_HBB2m1_SERPING1coI24_BGH228

<400>  33
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cacttgaccc cttggaattt tggtggagag gagcagaggt tgtcctggtg      420

tggtttaggt agtgtgagag gggtacctgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cagccacccc ctccaccttg gacacaggat gctgtggttt ctgagccagg tacaatgact      600

cctttggtaa gtgcagtgga agctgtacac tgcccaggca aaggtctggg caggtagggg      660

gtgactcaga tcccagccag tggacttagc ccctgtttgc tcctctgata actggggtga      720

ccttggttaa tattcaccag cagcctcccc tgttgcccct ctggatccac tgcttaaata      780

tggatgagga cagggccctg tctcctcagc ttcaggcacc accactgacc tgggacagtg      840

aatagatctt gagaacttca gggtgagtct atgggaccct tgatgttttc tttccccttc      900

ttttctatgg ttaagttcat gtcataggaa ggggagaagt aacagggtac acatattgac      960

caaatcaggg taattttgca tttgtaattt taaaaaatgc tttcttcttt taatatactt     1020

ttttgtttat cttatttcta atactttccc taatctcttt ctttcagggc aataatgata     1080

caatgtatca tgcctctttg caccattcta aagaataaca gtgataattt ctgggttaag     1140

gcaatagcaa tatttctgca tataaatatt tctgcatata aattgtaact gatgtaagag     1200

gtttcatatt gctaatagca gctacaatcc agctaccatt ctgcttttat tttctggttg     1260

ggataaggct ggattattct gagtccaagc taggcccttt tgctaatctt gttcatacct     1320

cttatcttcc tcccacagct cctgggcaac ctgctggtct ctctgctggc ccatcacttt     1380

ggcaaagcac tagtgccacc atggctagca ggctgaccct gctgaccctg ctgctcctgc     1440

tgctggctgg ggacagggcc tctagcaatc ccaatgccac ctctagctct agccaggatc     1500

ctgagagcct gcaggacagg ggggagggca aggtggccac cactgtgatc agcaagatgc     1560

tgtttgtgga gcccattctg gaggtgtctt ctctgcccac caccaatagc accactaatt     1620

ctgccaccaa gatcactgct aacaccactg atgagcccac cactcagcct accactgagc     1680

ccaccaccca gcccactatc cagcccaccc agcccaccac ccagctgcct actgacagcc     1740

ctacccagcc cactactggg agcttctgcc ctggccctgt gaccctgtgc tctgacctgg     1800

agagccacag cactgaggct gtgctggggg atgccctggt ggacttcagc ctgaagctgt     1860

accatgcctt ttctgccatg aagaaggtgg agaccaacat ggcctttagc cctttcagca     1920

ttgccagcct gctgactcag gtgctgctgg gggctgggga gaacaccaag accaacctgg     1980

agagcatcct gagctacccc aaggacttca cttgtgtgca ccaggccctg aagggcttca     2040

ctaccaaggg ggtgacttct gtgagccaga tcttccacag ccctgacctg gccatcaggg     2100

atacttttgt gaatgccagc aggaccctgt acagcagcag ccccagggtg ctgagcaaca     2160

actctgatgc taacctggag ctgatcaata cttgggtggc caagaacacc aacaacaaga     2220

tttctaggct gctggactct ctgccctctg acactaggct ggtgctgctg aatgccatct     2280

acctgtctgc caagtggaag accacctttg atcccaagaa gactaggatg gagcccttcc     2340

acttcaagaa ctctgtgatc aaggtgccca tgatgaacag caagaagtac cctgtggccc     2400

atttcattga ccagaccctg aaggccaagg tggggcagct gcagctgagc cacaatctga     2460

gcctggtgat tctggtgccc cagaatctga agcacagact ggaggacatg gagcaggctc     2520

tgtctccctc tgtgttcaag gccatcatgg agaagctgga gatgagcaag ttccagccca     2580

ctctgctgac tctgcctagg atcaaggtga ccaccagcca ggacatgctg agcattatgg     2640

agaagctgga gttctttgac ttcagctatg acctgaacct gtgtggcctg actgaggacc     2700

ctgatctgca ggtgtctgcc atgcagcacc agactgtgct ggagctgact gagactgggg     2760

tggaggctgc tgctgcctct gctatttctg tggccaggac cctgctggtg tttgaggtgc     2820

agcagccctt cctgtttgtg ctgtgggacc agcagcacaa gtttcctgtg ttcatgggga     2880

gggtgtatga ccccagggcc tgacatctag agctgaattc ctgcagccag ggggatcagc     2940

ctctactgtg ccttctagtt gccagccatc tgttgtttgc ccctccccct tgccttcctt     3000

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcaca     3060

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3120

ggattgggaa gacaatagca ggcatgctgg ggatgcagtg ggctctatgg cttctgaggc     3180

agaaagaacc agctggggct cgagatccac tagggccgca ggaaccccta gtgatggagt     3240

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     3300

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 3349


<210>  34
<211>  3674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_2xApoE_hAAT_HBB2m1_SERPING1co21_BGH228

<400>  34
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

ggtttaggta gtgtgagagg gaggctcaga ggcacacagg agtttctggg ctcaccctgc      480

ccccttccaa cccctcagtt cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc      540

cacactgaac aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca      600

aacagcaaac acacagccct ccctgcctgc tgaccttgga gctggggcag aggtcagaga      660

cctctctggg cccatgccac ctccaacatc cactcgaccc cttggaattt cggtggagag      720

gagcagaggt tgtcctggcg tggtttaggt agtgtgagag gggtacccgg ggatcttgct      780

accagtggaa cagccactaa ggattctgca gtgagagcag agggccagct aagtggtact      840

ctcccagaga ctgtctgact cacgccaccc cctccacctt ggacacagga cgctgtggtt      900

tctgagccag gtacaatgac tcctttcggt aagtgcagtg gaagctgtac actgcccagg      960

caaagcgtcc gggcagcgta ggcgggcgac tcagatccca gccagtggac ttagcccctg     1020

tttgctcctc cgataactgg ggtgaccttg gttaatattc accagcagcc tcccccgttg     1080

cccctctgga tccactgctt aaatacggac gaggacaggg ccctgtctcc tcagcttcag     1140

gcaccaccac tgacctggga cagtgaatag atcttgagaa cttcagggtg agtctatggg     1200

acccttgatg ttttctttcc ccttcttttc tatggttaag ttcatgtcat aggaagggga     1260

gaagtaacag ggtacacata ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa     1320

aatgctttct tcttttaata tacttttttg tttatcttat ttctaatact ttccctaatc     1380

tctttctttc agggcaataa tgatacaatg tatcatgcct ctttgcacca ttctaaagaa     1440

taacagtgat aatttctggg ttaaggcaat agcaatattt ctgcatataa atatttctgc     1500

atataaattg taactgatgt aagaggtttc atattgctaa tagcagctac aatccagcta     1560

ccattctgct tttattttct ggttgggata aggctggatt attctgagtc caagctaggc     1620

ccttttgcta atcttgttca tacctcttat cttcctccca cagctcctgg gcaacctgct     1680

ggtctctctg ctggcccatc actttggcaa agcactagtg ccaccatggc ctctaggctg     1740

actctgctga ctctgctgct cctgctgctg gctggggaca gggccagctc taaccccaat     1800

gctacttcta gctcctctca ggaccctgag agcctgcagg acagggggga gggcaaggtg     1860

gccaccactg tgatctctaa gatgctgttt gtggagccca tcctggaggt gagcagcctg     1920

cccaccacca acagcaccac caactctgcc actaagatca ctgccaacac cactgatgag     1980

cccaccaccc agcccactac tgagcccacc acccagccta ctatccagcc cacccagccc     2040

actacccagc tgcccactga cagccctacc cagcccacca ctggcagctt ctgccctggg     2100

cctgtgaccc tgtgctctga cctggagagc cattctactg aggctgtgct gggggatgcc     2160

ctggtggact tctctctgaa gctgtaccat gctttctctg ccatgaagaa ggtggagact     2220

aacatggctt ttagcccctt cagcattgct agcctgctga cccaggtgct gctgggggct     2280

ggggagaaca ctaagaccaa cctggaatct atcctgagct accccaagga cttcacctgt     2340

gtgcaccagg ccctgaaggg cttcaccacc aagggggtga cctctgtgag ccagatcttc     2400

cacagccctg acctggccat cagggatact tttgtgaatg ccagcagaac cctgtactct     2460

tctagcccca gggtgctgag caataattct gatgctaacc tggagctgat caatacctgg     2520

gtggctaaga ataccaacaa caagattagc aggctgctgg actctctgcc ttctgatacc     2580

aggctggtgc tgctgaatgc catttacctg tctgccaagt ggaagaccac ttttgaccct     2640

aagaagacta ggatggagcc tttccacttc aagaactctg tcattaaggt gcccatgatg     2700

aacagcaaga agtatcctgt ggcccacttt attgaccaga ctctgaaggc caaggtgggc     2760

cagctgcagc tgagccataa cctgagcctg gtgatcctgg tgccccagaa cctgaagcat     2820

aggctggagg acatggagca ggctctgagc ccctctgtgt tcaaggctat tatggagaag     2880

ctggagatga gcaagttcca gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc     2940

tctcaggaca tgctgagcat catggaaaag ctggagttct ttgacttttc ttatgacctg     3000

aatctgtgtg gcctgactga ggatcctgat ctgcaggtgt ctgccatgca gcaccagact     3060

gtgctggagc tgactgagac tggggtggag gctgctgctg cttctgccat ctctgtggcc     3120

aggaccctgc tggtgtttga ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag     3180

cacaagtttc ctgtgttcat gggcagggtg tatgacccca gagcctgaca tctagagctg     3240

aattcctgca gccaggggga tcagcctcta ctgtgccttc tagttgccag ccatctgttg     3300

tttgcccctc ccccttgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct     3360

aataaaatga ggaaattgca tcacattgtc tgagtaggtg tcattctatt ctggggggtg     3420

gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg     3480

cagtgggctc tatggcttct gaggcagaaa gaaccagctg gggctcgaga tccactaggg     3540

ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     3600

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     3660

gagcgagcgc gcag                                                       3674


<210>  35
<211>  4316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_4xApoE_hAAT_HBB2m1_SERPING1co21_BGH228

<400>  35
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

ggtttaggta gtgtgagagg gaggctcaga ggcacacagg agtttctggg ctcaccctgc      480

ccccttccaa cccctcagtt cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc      540

cacactgaac aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca      600

aacagcaaac acacagccct ccctgcctgc tgaccttgga gctggggcag aggtcagaga      660

cctctctggg cccatgccac ctccaacatc cactcgaccc cttggaattt cggtggagag      720

gagcagaggt tgtcctggcg tggtttaggt agtgtgagag ggaggctcag aggcacacag      780

gagtttctgg gctcaccctg cccccttcca acccctcagt tcccatcctc cagcagctgt      840

ttgtgtgctg cctctgaagt ccacactgaa caaacttcag cctactcatg tccctaaaat      900

gggcaaacat tgcaagcagc aaacagcaaa cacacagccc tccctgcctg ctgaccttgg      960

agctggggca gaggtcagag acctctctgg gcccatgcca cctccaacat ccactcgacc     1020

ccttggaatt tcggtggaga ggagcagagg ttgtcctggc gtggtttagg tagtgtgaga     1080

gggaggctca gaggcacaca ggagtttctg ggctcaccct gcccccttcc aacccctcag     1140

ttcccatcct ccagcagctg tttgtgtgct gcctctgaag tccacactga acaaacttca     1200

gcctactcat gtccctaaaa tgggcaaaca ttgcaagcag caaacagcaa acacacagcc     1260

ctccctgcct gctgaccttg gagctggggc agaggtcaga gacctctctg ggcccatgcc     1320

acctccaaca tccactcgac cccttggaat ttcggtggag aggagcagag gttgtcctgg     1380

cgtggtttag gtagtgtgag aggggtaccc ggggatcttg ctaccagtgg aacagccact     1440

aaggattctg cagtgagagc agagggccag ctaagtggta ctctcccaga gactgtctga     1500

ctcacgccac cccctccacc ttggacacag gacgctgtgg tttctgagcc aggtacaatg     1560

actcctttcg gtaagtgcag tggaagctgt acactgccca ggcaaagcgt ccgggcagcg     1620

taggcgggcg actcagatcc cagccagtgg acttagcccc tgtttgctcc tccgataact     1680

ggggtgacct tggttaatat tcaccagcag cctcccccgt tgcccctctg gatccactgc     1740

ttaaatacgg acgaggacag ggccctgtct cctcagcttc aggcaccacc actgacctgg     1800

gacagtgaat agatcttgag aacttcaggg tgagtctatg ggacccttga tgttttcttt     1860

ccccttcttt tctatggtta agttcatgtc ataggaaggg gagaagtaac agggtacaca     1920

tattgaccaa atcagggtaa ttttgcattt gtaattttaa aaaatgcttt cttcttttaa     1980

tatacttttt tgtttatctt atttctaata ctttccctaa tctctttctt tcagggcaat     2040

aatgatacaa tgtatcatgc ctctttgcac cattctaaag aataacagtg ataatttctg     2100

ggttaaggca atagcaatat ttctgcatat aaatatttct gcatataaat tgtaactgat     2160

gtaagaggtt tcatattgct aatagcagct acaatccagc taccattctg cttttatttt     2220

ctggttggga taaggctgga ttattctgag tccaagctag gcccttttgc taatcttgtt     2280

catacctctt atcttcctcc cacagctcct gggcaacctg ctggtctctc tgctggccca     2340

tcactttggc aaagcactag tgccaccatg gcctctaggc tgactctgct gactctgctg     2400

ctcctgctgc tggctgggga cagggccagc tctaacccca atgctacttc tagctcctct     2460

caggaccctg agagcctgca ggacaggggg gagggcaagg tggccaccac tgtgatctct     2520

aagatgctgt ttgtggagcc catcctggag gtgagcagcc tgcccaccac caacagcacc     2580

accaactctg ccactaagat cactgccaac accactgatg agcccaccac ccagcccact     2640

actgagccca ccacccagcc tactatccag cccacccagc ccactaccca gctgcccact     2700

gacagcccta cccagcccac cactggcagc ttctgccctg ggcctgtgac cctgtgctct     2760

gacctggaga gccattctac tgaggctgtg ctgggggatg ccctggtgga cttctctctg     2820

aagctgtacc atgctttctc tgccatgaag aaggtggaga ctaacatggc ttttagcccc     2880

ttcagcattg ctagcctgct gacccaggtg ctgctggggg ctggggagaa cactaagacc     2940

aacctggaat ctatcctgag ctaccccaag gacttcacct gtgtgcacca ggccctgaag     3000

ggcttcacca ccaagggggt gacctctgtg agccagatct tccacagccc tgacctggcc     3060

atcagggata cttttgtgaa tgccagcaga accctgtact cttctagccc cagggtgctg     3120

agcaataatt ctgatgctaa cctggagctg atcaatacct gggtggctaa gaataccaac     3180

aacaagatta gcaggctgct ggactctctg ccttctgata ccaggctggt gctgctgaat     3240

gccatttacc tgtctgccaa gtggaagacc acttttgacc ctaagaagac taggatggag     3300

cctttccact tcaagaactc tgtcattaag gtgcccatga tgaacagcaa gaagtatcct     3360

gtggcccact ttattgacca gactctgaag gccaaggtgg gccagctgca gctgagccat     3420

aacctgagcc tggtgatcct ggtgccccag aacctgaagc ataggctgga ggacatggag     3480

caggctctga gcccctctgt gttcaaggct attatggaga agctggagat gagcaagttc     3540

cagcccactc tgctgaccct gcccagaatc aaggtgacca cctctcagga catgctgagc     3600

atcatggaaa agctggagtt ctttgacttt tcttatgacc tgaatctgtg tggcctgact     3660

gaggatcctg atctgcaggt gtctgccatg cagcaccaga ctgtgctgga gctgactgag     3720

actggggtgg aggctgctgc tgcttctgcc atctctgtgg ccaggaccct gctggtgttt     3780

gaggtgcagc agcccttcct gtttgtgctg tgggaccagc agcacaagtt tcctgtgttc     3840

atgggcaggg tgtatgaccc cagagcctga catctagagc tgaattcctg cagccagggg     3900

gatcagcctc tactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccttgc     3960

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     4020

catcacattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     4080

agggggagga ttgggaagac aatagcaggc atgctgggga tgcagtgggc tctatggctt     4140

ctgaggcaga aagaaccagc tggggctcga gatccactag ggccgcagga acccctagtg     4200

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag     4260

gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcag         4316


<210>  36
<211>  3674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_hAAT_HBB2m1_SERPING1co21_2xApoE_BGH228

<400>  36
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtcc      120

ggggatcttg ctaccagtgg aacagccact aaggattctg cagtgagagc agagggccag      180

ctaagtggta ctctcccaga gactgtctga ctcacgccac cccctccacc ttggacacag      240

gacgctgtgg tttctgagcc aggtacaatg actcctttcg gtaagtgcag tggaagctgt      300

acactgccca ggcaaagcgt ccgggcagcg taggcgggcg actcagatcc cagccagtgg      360

acttagcccc tgtttgctcc tccgataact ggggtgacct tggttaatat tcaccagcag      420

cctcccccgt tgcccctctg gatccactgc ttaaatacgg acgaggacag ggccctgtct      480

cctcagcttc aggcaccacc actgacctgg gacagtgaat agatcttgag aacttcaggg      540

tgagtctatg ggacccttga tgttttcttt ccccttcttt tctatggtta agttcatgtc      600

ataggaaggg gagaagtaac agggtacaca tattgaccaa atcagggtaa ttttgcattt      660

gtaattttaa aaaatgcttt cttcttttaa tatacttttt tgtttatctt atttctaata      720

ctttccctaa tctctttctt tcagggcaat aatgatacaa tgtatcatgc ctctttgcac      780

cattctaaag aataacagtg ataatttctg ggttaaggca atagcaatat ttctgcatat      840

aaatatttct gcatataaat tgtaactgat gtaagaggtt tcatattgct aatagcagct      900

acaatccagc taccattctg cttttatttt ctggttggga taaggctgga ttattctgag      960

tccaagctag gcccttttgc taatcttgtt catacctctt atcttcctcc cacagctcct     1020

gggcaacctg ctggtctctc tgctggccca tcactttggc aaagcactag tgccaccatg     1080

gcctctaggc tgactctgct gactctgctg ctcctgctgc tggctgggga cagggccagc     1140

tctaacccca atgctacttc tagctcctct caggaccctg agagcctgca ggacaggggg     1200

gagggcaagg tggccaccac tgtgatctct aagatgctgt ttgtggagcc catcctggag     1260

gtgagcagcc tgcccaccac caacagcacc accaactctg ccactaagat cactgccaac     1320

accactgatg agcccaccac ccagcccact actgagccca ccacccagcc tactatccag     1380

cccacccagc ccactaccca gctgcccact gacagcccta cccagcccac cactggcagc     1440

ttctgccctg ggcctgtgac cctgtgctct gacctggaga gccattctac tgaggctgtg     1500

ctgggggatg ccctggtgga cttctctctg aagctgtacc atgctttctc tgccatgaag     1560

aaggtggaga ctaacatggc ttttagcccc ttcagcattg ctagcctgct gacccaggtg     1620

ctgctggggg ctggggagaa cactaagacc aacctggaat ctatcctgag ctaccccaag     1680

gacttcacct gtgtgcacca ggccctgaag ggcttcacca ccaagggggt gacctctgtg     1740

agccagatct tccacagccc tgacctggcc atcagggata cttttgtgaa tgccagcaga     1800

accctgtact cttctagccc cagggtgctg agcaataatt ctgatgctaa cctggagctg     1860

atcaatacct gggtggctaa gaataccaac aacaagatta gcaggctgct ggactctctg     1920

ccttctgata ccaggctggt gctgctgaat gccatttacc tgtctgccaa gtggaagacc     1980

acttttgacc ctaagaagac taggatggag cctttccact tcaagaactc tgtcattaag     2040

gtgcccatga tgaacagcaa gaagtatcct gtggcccact ttattgacca gactctgaag     2100

gccaaggtgg gccagctgca gctgagccat aacctgagcc tggtgatcct ggtgccccag     2160

aacctgaagc ataggctgga ggacatggag caggctctga gcccctctgt gttcaaggct     2220

attatggaga agctggagat gagcaagttc cagcccactc tgctgaccct gcccagaatc     2280

aaggtgacca cctctcagga catgctgagc atcatggaaa agctggagtt ctttgacttt     2340

tcttatgacc tgaatctgtg tggcctgact gaggatcctg atctgcaggt gtctgccatg     2400

cagcaccaga ctgtgctgga gctgactgag actggggtgg aggctgctgc tgcttctgcc     2460

atctctgtgg ccaggaccct gctggtgttt gaggtgcagc agcccttcct gtttgtgctg     2520

tgggaccagc agcacaagtt tcctgtgttc atgggcaggg tgtatgaccc cagagcctga     2580

catctagaag gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc     2640

ctcagttccc atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa     2700

cttcagccta ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca     2760

cagccctccc tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc     2820

atgccacctc caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt     2880

cctggcgtgg tttaggtagt gtgagaggga ggctcagagg cacacaggag tttctgggct     2940

caccctgccc ccttccaacc cctcagttcc catcctccag cagctgtttg tgtgctgcct     3000

ctgaagtcca cactgaacaa acttcagcct actcatgtcc ctaaaatggg caaacattgc     3060

aagcagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag     3120

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg     3180

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg tctagagctg     3240

aattcctgca gccaggggga tcagcctcta ctgtgccttc tagttgccag ccatctgttg     3300

tttgcccctc ccccttgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct     3360

aataaaatga ggaaattgca tcacattgtc tgagtaggtg tcattctatt ctggggggtg     3420

gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg     3480

cagtgggctc tatggcttct gaggcagaaa gaaccagctg gggctcgaga tccactaggg     3540

ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     3600

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     3660

gagcgagcgc gcag                                                       3674


<210>  37
<211>  4315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_hAAT_HBB2m1_SERPING1co21_4xApoE_BGH228

<400>  37
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtcc      120

ggggatcttg ctaccagtgg aacagccact aaggattctg cagtgagagc agagggccag      180

ctaagtggta ctctcccaga gactgtctga ctcacgccac cccctccacc ttggacacag      240

gacgctgtgg tttctgagcc aggtacaatg actcctttcg gtaagtgcag tggaagctgt      300

acactgccca ggcaaagcgt ccgggcagcg taggcgggcg actcagatcc cagccagtgg      360

acttagcccc tgtttgctcc tccgataact ggggtgacct tggttaatat tcaccagcag      420

cctcccccgt tgcccctctg gatccactgc ttaaatacgg acgaggacag ggccctgtct      480

cctcagcttc aggcaccacc actgacctgg gacagtgaat agatcttgag aacttcaggg      540

tgagtctatg ggacccttga tgttttcttt ccccttcttt tctatggtta agttcatgtc      600

ataggaaggg gagaagtaac agggtacaca tattgaccaa atcagggtaa ttttgcattt      660

gtaattttaa aaaatgcttt cttcttttaa tatacttttt tgtttatctt atttctaata      720

ctttccctaa tctctttctt tcagggcaat aatgatacaa tgtatcatgc ctctttgcac      780

cattctaaag aataacagtg ataatttctg ggttaaggca atagcaatat ttctgcatat      840

aaatatttct gcatataaat tgtaactgat gtaagaggtt tcatattgct aatagcagct      900

acaatccagc taccattctg cttttatttt ctggttggga taaggctgga ttattctgag      960

tccaagctag gcccttttgc taatcttgtt catacctctt atcttcctcc cacagctcct     1020

gggcaacctg ctggtctctc tgctggccca tcactttggc aaagcactag tgccaccatg     1080

gcctctaggc tgactctgct gactctgctg ctcctgctgc tggctgggga cagggccagc     1140

tctaacccca atgctacttc tagctcctct caggaccctg agagcctgca ggacaggggg     1200

gagggcaagg tggccaccac tgtgatctct aagatgctgt ttgtggagcc catcctggag     1260

gtgagcagcc tgcccaccac caacagcacc accaactctg ccactaagat cactgccaac     1320

accactgatg agcccaccac ccagcccact actgagccca ccacccagcc tactatccag     1380

cccacccagc ccactaccca gctgcccact gacagcccta cccagcccac cactggcagc     1440

ttctgccctg ggcctgtgac cctgtgctct gacctggaga gccattctac tgaggctgtg     1500

ctgggggatg ccctggtgga cttctctctg aagctgtacc atgctttctc tgccatgaag     1560

aaggtggaga ctaacatggc ttttagcccc ttcagcattg ctagcctgct gacccaggtg     1620

ctgctggggg ctggggagaa cactaagacc aacctggaat ctatcctgag ctaccccaag     1680

gacttcacct gtgtgcacca ggccctgaag ggcttcacca ccaagggggt gacctctgtg     1740

agccagatct tccacagccc tgacctggcc atcagggata cttttgtgaa tgccagcaga     1800

accctgtact cttctagccc cagggtgctg agcaataatt ctgatgctaa cctggagctg     1860

atcaatacct gggtggctaa gaataccaac aacaagatta gcaggctgct ggactctctg     1920

ccttctgata ccaggctggt gctgctgaat gccatttacc tgtctgccaa gtggaagacc     1980

acttttgacc ctaagaagac taggatggag cctttccact tcaagaactc tgtcattaag     2040

gtgcccatga tgaacagcaa gaagtatcct gtggcccact ttattgacca gactctgaag     2100

gccaaggtgg gccagctgca gctgagccat aacctgagcc tggtgatcct ggtgccccag     2160

aacctgaagc ataggctgga ggacatggag caggctctga gcccctctgt gttcaaggct     2220

attatggaga agctggagat gagcaagttc cagcccactc tgctgaccct gcccagaatc     2280

aaggtgacca cctctcagga catgctgagc atcatggaaa agctggagtt ctttgacttt     2340

tcttatgacc tgaatctgtg tggcctgact gaggatcctg atctgcaggt gtctgccatg     2400

cagcaccaga ctgtgctgga gctgactgag actggggtgg aggctgctgc tgcttctgcc     2460

atctctgtgg ccaggaccct gctggtgttt gaggtgcagc agcccttcct gtttgtgctg     2520

tgggaccagc agcacaagtt tcctgtgttc atgggcaggg tgtatgaccc cagagcctga     2580

catctagaag gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc     2640

ctcagttccc atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa     2700

cttcagccta ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca     2760

cagccctccc tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc     2820

atgccacctc caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt     2880

cctggcgggt ttaggtagtg tgagagggag gctcagaggc acacaggagt ttctgggctc     2940

accctgcccc cttccaaccc ctcagttccc atcctccagc agctgtttgt gtgctgcctc     3000

tgaagtccac actgaacaaa cttcagccta ctcatgtccc taaaatgggc aaacattgca     3060

agcagcaaac agcaaacaca cagccctccc tgcctgctga ccttggagct ggggcagagg     3120

tcagagacct ctctgggccc atgccacctc caacatccac tcgacccctt ggaatttcgg     3180

tggagaggag cagaggttgt cctggcgtgg tttaggtagt gtgagaggga ggctcagagg     3240

cacacaggag tttctgggct caccctgccc ccttccaacc cctcagttcc catcctccag     3300

cagctgtttg tgtgctgcct ctgaagtcca cactgaacaa acttcagcct actcatgtcc     3360

ctaaaatggg caaacattgc aagcagcaaa cagcaaacac acagccctcc ctgcctgctg     3420

accttggagc tggggcagag gtcagagacc tctctgggcc catgccacct ccaacatcca     3480

ctcgacccct tggaatttcg gtggagagga gcagaggttg tcctggcgtg gtttaggtag     3540

tgtgagaggg aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac     3600

ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca     3660

aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca     3720

cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc     3780

ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt     3840

gtcctggcgt ggtttaggta gtgtgagagg gtctagagct gaattcctgc agccaggggg     3900

atcagcctct actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccttgcc     3960

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4020

atcacattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4080

gggggaggat tgggaagaca atagcaggca tgctggggat gcagtgggct ctatggcttc     4140

tgaggcagaa agaaccagct ggggctcgag atccactagg gccgcaggaa cccctagtga     4200

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg     4260

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcag          4315


<210>  38
<211>  3867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_hAATenh_BGH228

<400>  38
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca ctaagaccaa     1980

cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg ccctgaaggg     2040

cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca gggtgctgag     2160

caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga ataccaacaa     2220

caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc tgctgaatgc     2280

catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta ggatggagcc     2340

tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga agtatcctgt     2400

ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc tgagccataa     2460

cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg acatggagca     2520

ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat     2640

catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg gcctgactga     2700

ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

gggcagggtg tatgacccca gagcctgaca tctagacctg cagtcttcag agggccaccg     2940

cagctccagt gccacggcag gaggctgttc ctgaatagcc cctgtggtaa gggccaggag     3000

agtccttcca tcctccaagg ccctgctaaa ggacacagca gccaggaagt cccctgggcc     3060

cctagctgaa ggacagcctg ctccctccgt ctctaccagg aatggccttg tcctatggaa     3120

ggcactgccc catcccaaac taatctagga atcactgtct aaccactcac tgtcatgaat     3180

gtgtacttaa aggatgaggt tgagtcatac caaatagtga tttcgatagt tcaaaatggt     3240

gaaattagca attctacatg attcagtcta atcaatggat accgactgtt tcccacacaa     3300

gtctcctgtt ctcttaagct tactcactga cagcctttca ctctccacaa atacattaaa     3360

gatatggcca tcaccaagcc ccctaggatg acaccagacc tgagagtctg aagacctgga     3420

tcctctagag ctgaattcct gcagccaggg ggatcagcct ctactgtgcc ttctagttgc     3480

cagccatctg ttgtttgccc ctcccccttg ccttccttga ccctggaagg tgccactccc     3540

actgtccttt cctaataaaa tgaggaaatt gcatcacatt gtctgagtag gtgtcattct     3600

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3660

catgctgggg atgcagtggg ctctatggct tctgaggcag aaagaaccag ctggggctcg     3720

agatccacta gggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc     3780

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     3840

ggcctcagtg agcgagcgag cgcgcag                                         3867


<210>  39
<211>  3867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_hAATenh(co1)_BGH228

<400>  39
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca ctaagaccaa     1980

cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg ccctgaaggg     2040

cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca gggtgctgag     2160

caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga ataccaacaa     2220

caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc tgctgaatgc     2280

catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta ggatggagcc     2340

tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga agtatcctgt     2400

ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc tgagccataa     2460

cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg acatggagca     2520

ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat     2640

catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg gcctgactga     2700

ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

gggcagggtg tatgacccca gagcctgaca tctagacctg cagtcttcag agggccactg     2940

cagctccagt gccatggcag gaggctgttc ctgaatagcc cctgtggtaa gggccaggag     3000

agtccttcca tcctccaagg ccctgctaaa ggacacagca gccaggaagt cccctgggcc     3060

cctagctgaa ggacagcctg ctccctctgt ctctaccagg aatggccttg tcctatggaa     3120

ggcactgccc catcccaaac taatctagga atcactgtct aaccactcac tgtcatgaat     3180

gtgtacttaa aggatgaggt tgagtcatac caaatagtga ttttgatagt tcaaaatggt     3240

gaaattagca attctacatg attcagtcta atcaatggat actgactgtt tcccacacaa     3300

gtctcctgtt ctcttaagct tactcactga cagcctttca ctctccacaa atacattaaa     3360

gatatggcca tcaccaagcc ccctaggatg acaccagacc tgagagtctg aagacctgga     3420

tcctctagag ctgaattcct gcagccaggg ggatcagcct ctactgtgcc ttctagttgc     3480

cagccatctg ttgtttgccc ctcccccttg ccttccttga ccctggaagg tgccactccc     3540

actgtccttt cctaataaaa tgaggaaatt gcatcacatt gtctgagtag gtgtcattct     3600

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     3660

catgctgggg atgcagtggg ctctatggct tctgaggcag aaagaaccag ctggggctcg     3720

agatccacta gggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc     3780

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     3840

ggcctcagtg agcgagcgag cgcgcag                                         3867


<210>  40
<211>  3607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_WPRE3_BGH228

<400>  40
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca ctaagaccaa     1980

cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg ccctgaaggg     2040

cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca gggtgctgag     2160

caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga ataccaacaa     2220

caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc tgctgaatgc     2280

catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta ggatggagcc     2340

tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga agtatcctgt     2400

ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc tgagccataa     2460

cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg acatggagca     2520

ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat     2640

catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg gcctgactga     2700

ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

gggcagggtg tatgacccca gagcctgaca tctagaaatc aacctctgga ttacaaaatt     2940

tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct     3000

gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg     3060

tataaatcct ggttagttct tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc     3120

tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttctagag ctgaattcct     3180

gcagccaggg ggatcagcct ctactgtgcc ttctagttgc cagccatctg ttgtttgccc     3240

ctcccccttg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     3300

tgaggaaatt gcatcacatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3360

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcagtggg     3420

ctctatggct tctgaggcag aaagaaccag ctggggctcg agatccacta gggccgcagg     3480

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     3540

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     3600

cgcgcag                                                               3607


<210>  41
<211>  3607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_WPRE3co1_BGH228

<400>  41
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca ctaagaccaa     1980

cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg ccctgaaggg     2040

cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca gggtgctgag     2160

caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga ataccaacaa     2220

caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc tgctgaatgc     2280

catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta ggatggagcc     2340

tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga agtatcctgt     2400

ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc tgagccataa     2460

cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg acatggagca     2520

ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat     2640

catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg gcctgactga     2700

ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

gggcagggtg tatgacccca gagcctgaca tctagaaatc aacctctgga ttacaaaatt     2940

tgtgaaagat tgactggtat tcttaactat gttgctcctt ttatgctatg tggatatgct     3000

gctttaatgc ctttgtatca tgctattgct tcctgtatgg ctttcatttt ctcctccttg     3060

tataaatcct ggttagttct tgccatggtg gaactcattg ctgcctgcct tgcctgctgc     3120

tggacagggg cttggctgtt gggcactgac aattctgtgg tgttctagag ctgaattcct     3180

gcagccaggg ggatcagcct ctactgtgcc ttctagttgc cagccatctg ttgtttgccc     3240

ctcccccttg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     3300

tgaggaaatt gcatcacatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3360

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcagtggg     3420

ctctatggct tctgaggcag aaagaaccag ctggggctcg agatccacta gggccgcagg     3480

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     3540

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     3600

cgcgcag                                                               3607


<210>  42
<211>  3949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_WPRE_BGH228

<400>  42
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca ctaagaccaa     1980

cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg ccctgaaggg     2040

cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca gggtgctgag     2160

caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga ataccaacaa     2220

caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc tgctgaatgc     2280

catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta ggatggagcc     2340

tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga agtatcctgt     2400

ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc tgagccataa     2460

cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg acatggagca     2520

ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat     2640

catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg gcctgactga     2700

ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

gggcagggtg tatgacccca gagcctgaca tctagaaatc aacctctgga ttacaaaatt     2940

tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct     3000

gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg     3060

tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc     3120

gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt     3180

cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc     3240

gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg     3300

ttgtcgggga agctgacgtc ctttccatgg ctgctcgcct gtgttgccac ctggattctg     3360

cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc     3420

ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg     3480

atctcccttt gggccgcctc cccgctctag agctgaattc ctgcagccag ggggatcagc     3540

ctctactgtg ccttctagtt gccagccatc tgttgtttgc ccctccccct tgccttcctt     3600

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcaca     3660

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3720

ggattgggaa gacaatagca ggcatgctgg ggatgcagtg ggctctatgg cttctgaggc     3780

agaaagaacc agctggggct cgagatccac tagggccgca ggaaccccta gtgatggagt     3840

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     3900

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 3949


<210>  43
<211>  3949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_WPREco1_BGH228

<400>  43
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca ctaagaccaa     1980

cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg ccctgaaggg     2040

cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca gggtgctgag     2160

caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga ataccaacaa     2220

caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc tgctgaatgc     2280

catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta ggatggagcc     2340

tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga agtatcctgt     2400

ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc tgagccataa     2460

cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg acatggagca     2520

ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat     2640

catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg gcctgactga     2700

ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

gggcagggtg tatgacccca gagcctgaca tctagaaatc aacctctgga ttacaaaatt     2940

tgtgaaagat tgactggtat tcttaactat gttgctcctt ttatgctatg tggatatgct     3000

gctttaatgc ctttgtatca tgctattgct tcctgtatgg ctttcatttt ctcctccttg     3060

tataaatcct ggttgctgtc tctttatgag gagttgtggc ctgttgtcag gcaatgtggt     3120

gtggtgtgca ctgtgtttgc tgatgcaacc cccactggtt ggggcattgc caccacctgt     3180

cagctccttt ctgggacttt tgctttcccc ctccctattg ccatggtgga actcattgct     3240

gcctgccttg cctgctgctg gacaggggct tggctgttgg gcactgacaa ttctgtggtg     3300

ttgttgggga agctgatgtc ctttccatgg ctgcttgcct gtgttgccac ctggattctg     3360

tgtgggatgt ccttctgcta tgtccctttg gccctcaatc cagtggacct tccttcctgt     3420

ggcctgctgc tggctctgtg gcctcttctg tgtctttgcc tttgccctca gatgagttgg     3480

atctcccttt gggctgcctc cctgctctag agctgaattc ctgcagccag ggggatcagc     3540

ctctactgtg ccttctagtt gccagccatc tgttgtttgc ccctccccct tgccttcctt     3600

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcaca     3660

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3720

ggattgggaa gacaatagca ggcatgctgg ggatgcagtg ggctctatgg cttctgaggc     3780

agaaagaacc agctggggct cgagatccac tagggccgca ggaaccccta gtgatggagt     3840

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     3900

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                 3949


<210>  44
<211>  3354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1(-ATG)_SERPING1co21_BGH228

<400>  44
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcctgagaa cttcagggtg agtctttggg acccttgttg ttttctttcc      900

ccttcttttc tttggttaag ttcttgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa attgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaatat     1080

tgatacattg tatcttgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgttgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca ctaagaccaa     1980

cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg ccctgaaggg     2040

cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca gggtgctgag     2160

caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga ataccaacaa     2220

caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc tgctgaatgc     2280

catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta ggatggagcc     2340

tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga agtatcctgt     2400

ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc tgagccataa     2460

cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg acatggagca     2520

ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat     2640

catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg gcctgactga     2700

ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

gggcagggtg tatgacccca gagcctgaca tctagagctg aattcctgca gccaggggga     2940

tcagcctcta ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccttgcct     3000

tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca     3060

tcacattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag     3120

ggggaggatt gggaagacaa tagcaggcat gctggggatg cagtgggctc tatggcttct     3180

gaggcagaaa gaaccagctg gggctcgaga tccactaggg ccgcaggaac ccctagtgat     3240

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     3300

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag           3354


<210>  45
<211>  4946
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_SERPING1co21(Intron 1-2, 2-3)_BGH228

<400>  45
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atctagtctg cactggagct gcctggtgac cagaagtttg gagtaggttt      900

ggtgctgggc aggggtgggg agtagggtgg aaagcatgga gtgaagaggt ctagggaggg      960

ggtctcctca cccccgcctt cctgcccgcc ttgatctcgg gggtctctat aggcttgctt     1020

ccacctggga cttctgcctc ctcctacccc agcccctccc gcctcaggcc tgttgtgctc     1080

agccccccag gacctcccct cccccacgcc tctggcctca ttgtttggtt aaagcaggac     1140

cccctccccc tcccaccacc tcccctccga ctgaacagat ggacagagac ccgggcccac     1200

ggggagagga agggccagcc ggtgccggga aagggaagcg gtttggggaa aacaaaacag     1260

agggaggagc cagggagaag gtggccccag gagggaggag gagggaattc gctaagaggg     1320

actggggcct gagacggaat gggggcgggc cccgggcggg gtgggggccc ctgggctccc     1380

agggtgggag ctggctccga ggctggctgg ctccgcaggt ccgctgacgt cgccgcccag     1440

atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggtatgtggt     1500

cccttgtggg atgggggacg ggggtggaga cgggaggcgg gatggtgcgg ggtgcgggcg     1560

gtggctgagg attaaccctt caggctccgg ggaatgagga gagctcctct tgggatcatt     1620

gagtgtgatc cttgcacacg cactcgtaga tggtggaaag agctcaggac tcagacagat     1680

gcaagttcta atcttggcgg gccatgtagg agctgcgcag cgtggtcctg aggacgtcac     1740

ttttctcagc ctactcctcc tgatttataa aatgttgaat aaacagatcc caccctgtcc     1800

accaagcagg cttggcagga ggatcacata gggcaaggag atgggaagca ttttgtgata     1860

tcaaagcaag agtttgttgt agaaaagagc tgtggggagg agaggtttgg ctgctgtgac     1920

acagacggtg gtcccaggct agggcctgtg aagacaggga agaatggtag caaacatacg     1980

tgggtctggg tgggggtcaa tagcagtgag aggtcccagt ggtctgggag gtcatggact     2040

agaaataagg ctaagaagtg caggatccca ggagaaaggt aggtaggggt gtgtgtatgt     2100

gcgtgtgtgt gtgtgtgcac gcgcaagttg gtatcacata ctcagcagat gatgtagtta     2160

tgagcaggga gtttggaatc agagaccttg ttttgacccc tagctgtttc tcccatttct     2220

gtgagaccct ggactagtta atatgtgtcg gtatgagttt ctctacctgt gaaatggagc     2280

taatgcgtgg tttctcagtg gaggatctgt tgacattggg gctggataat tcattgctga     2340

ggggctaccc tgcgcatttt aggatgtttt gcagtatatc tctagcctct acgcactaga     2400

ttccggtagc atcttccctg ctgtctccct gtgacaacca aaaatgtctc tggacattgc     2460

caaatatccc ctgggagtca aaattgtttc agagccgctg gcctatacta cttctctctc     2520

cctcccttcc tgcctccctt ctttcctcct tccctttctt cgttcccttc ctaatgtgta     2580

ctgtttttcc acacccacta atgggttgca acccacagtt taaaaattta ctgttctaaa     2640

tcaaggagca caagttcaaa tgtctgtact agccaagcaa gtgagtcaaa caggtagata     2700

tttacaggaa attgcaagaa catagataaa tgacaacact cagcttcact gtttggaaaa     2760

caacttccta cagggcagta attggtcaga gattacagag tccctgacta tccctcatct     2820

tctgcagagc acattcctgt gcacccccac cctcaccctg tattgcccct tctctgagga     2880

attagtggtg gtggttctaa gacagattgc tcatctgccg cactgtcaga aattactctc     2940

ttgtacagga cattttccac atccacacct tctcttcctg ctttgagtat tttagaggac     3000

tgtgcctcgt agtaagaaaa aaatgaaact cagtttcttg aaccacagga cagggccagc     3060

tctaacccca atgctacttc tagctcctct caggaccctg agagcctgca ggacaggggg     3120

gagggcaagg tggccaccac tgtgatctct aagatgctgt ttgtggagcc catcctggag     3180

gtgagcagcc tgcccaccac caacagcacc accaactctg ccactaagat cactgccaac     3240

accactgatg agcccaccac ccagcccact actgagccca ccacccagcc tactatccag     3300

cccacccagc ccactaccca gctgcccact gacagcccta cccagcccac cactggcagc     3360

ttctgccctg ggcctgtgac cctgtgctct gacctggaga gccattctac tgaggctgtg     3420

ctgggggatg ccctggtgga cttctctctg aagctgtacc atgctttctc tgccatgaag     3480

aaggtggaga ctaacatggc ttttagcccc ttcagcattg ctagcctgct gacccaggtg     3540

ctgctggggg ctggggagaa cactaagacc aacctggaat ctatcctgag ctaccccaag     3600

gacttcacct gtgtgcacca ggccctgaag ggcttcacca ccaagggggt gacctctgtg     3660

agccagatct tccacagccc tgacctggcc atcagggata cttttgtgaa tgccagcaga     3720

accctgtact cttctagccc cagggtgctg agcaataatt ctgatgctaa cctggagctg     3780

atcaatacct gggtggctaa gaataccaac aacaagatta gcaggctgct ggactctctg     3840

ccttctgata ccaggctggt gctgctgaat gccatttacc tgtctgccaa gtggaagacc     3900

acttttgacc ctaagaagac taggatggag cctttccact tcaagaactc tgtcattaag     3960

gtgcccatga tgaacagcaa gaagtatcct gtggcccact ttattgacca gactctgaag     4020

gccaaggtgg gccagctgca gctgagccat aacctgagcc tggtgatcct ggtgccccag     4080

aacctgaagc ataggctgga ggacatggag caggctctga gcccctctgt gttcaaggct     4140

attatggaga agctggagat gagcaagttc cagcccactc tgctgaccct gcccagaatc     4200

aaggtgacca cctctcagga catgctgagc atcatggaaa agctggagtt ctttgacttt     4260

tcttatgacc tgaatctgtg tggcctgact gaggatcctg atctgcaggt gtctgccatg     4320

cagcaccaga ctgtgctgga gctgactgag actggggtgg aggctgctgc tgcttctgcc     4380

atctctgtgg ccaggaccct gctggtgttt gaggtgcagc agcccttcct gtttgtgctg     4440

tgggaccagc agcacaagtt tcctgtgttc atgggcaggg tgtatgaccc cagagcctga     4500

catctagagc tgaattcctg cagccagggg gatcagcctc tactgtgcct tctagttgcc     4560

agccatctgt tgtttgcccc tcccccttgc cttccttgac cctggaaggt gccactccca     4620

ctgtcctttc ctaataaaat gaggaaattg catcacattg tctgagtagg tgtcattcta     4680

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     4740

atgctgggga tgcagtgggc tctatggctt ctgaggcaga aagaaccagc tggggctcga     4800

gatccactag ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct     4860

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     4920

gcctcagtga gcgagcgagc gcgcag                                          4946


<210>  46
<211>  4911
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1co21(Intron 2-3)_BGH228

<400>  46
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggtat gtggtccctt gtgggatggg ggacgggggt ggagacggga     1500

ggcgggatgg tgcggggtgc gggcggtggc tgaggattaa cccttcaggc tccggggaat     1560

gaggagagct cctcttggga tcattgagtg tgatccttgc acacgcactc gtagatggtg     1620

gaaagagctc aggactcaga cagatgcaag ttctaatctt ggcgggccat gtaggagctg     1680

cgcagcgtgg tcctgaggac gtcacttttc tcagcctact cctcctgatt tataaaatgt     1740

tgaataaaca gatcccaccc tgtccaccaa gcaggcttgg caggaggatc acatagggca     1800

aggagatggg aagcattttg tgatatcaaa gcaagagttt gttgtagaaa agagctgtgg     1860

ggaggagagg tttggctgct gtgacacaga cggtggtccc aggctagggc ctgtgaagac     1920

agggaagaat ggtagcaaac atacgtgggt ctgggtgggg gtcaatagca gtgagaggtc     1980

ccagtggtct gggaggtcat ggactagaaa taaggctaag aagtgcagga tcccaggaga     2040

aaggtaggta ggggtgtgtg tatgtgcgtg tgtgtgtgtg tgcacgcgca agttggtatc     2100

acatactcag cagatgatgt agttatgagc agggagtttg gaatcagaga ccttgttttg     2160

acccctagct gtttctccca tttctgtgag accctggact agttaatatg tgtcggtatg     2220

agtttctcta cctgtgaaat ggagctaatg cgtggtttct cagtggagga tctgttgaca     2280

ttggggctgg ataattcatt gctgaggggc taccctgcgc attttaggat gttttgcagt     2340

atatctctag cctctacgca ctagattccg gtagcatctt ccctgctgtc tccctgtgac     2400

aaccaaaaat gtctctggac attgccaaat atcccctggg agtcaaaatt gtttcagagc     2460

cgctggccta tactacttct ctctccctcc cttcctgcct cccttctttc ctccttccct     2520

ttcttcgttc ccttcctaat gtgtactgtt tttccacacc cactaatggg ttgcaaccca     2580

cagtttaaaa atttactgtt ctaaatcaag gagcacaagt tcaaatgtct gtactagcca     2640

agcaagtgag tcaaacaggt agatatttac aggaaattgc aagaacatag ataaatgaca     2700

acactcagct tcactgtttg gaaaacaact tcctacaggg cagtaattgg tcagagatta     2760

cagagtccct gactatccct catcttctgc agagcacatt cctgtgcacc cccaccctca     2820

ccctgtattg ccccttctct gaggaattag tggtggtggt tctaagacag attgctcatc     2880

tgccgcactg tcagaaatta ctctcttgta caggacattt tccacatcca caccttctct     2940

tcctgctttg agtattttag aggactgtgc ctcgtagtaa gaaaaaaatg aaactcagtt     3000

tcttgaacca caggacaggg ccagctctaa ccccaatgct acttctagct cctctcagga     3060

ccctgagagc ctgcaggaca ggggggaggg caaggtggcc accactgtga tctctaagat     3120

gctgtttgtg gagcccatcc tggaggtgag cagcctgccc accaccaaca gcaccaccaa     3180

ctctgccact aagatcactg ccaacaccac tgatgagccc accacccagc ccactactga     3240

gcccaccacc cagcctacta tccagcccac ccagcccact acccagctgc ccactgacag     3300

ccctacccag cccaccactg gcagcttctg ccctgggcct gtgaccctgt gctctgacct     3360

ggagagccat tctactgagg ctgtgctggg ggatgccctg gtggacttct ctctgaagct     3420

gtaccatgct ttctctgcca tgaagaaggt ggagactaac atggctttta gccccttcag     3480

cattgctagc ctgctgaccc aggtgctgct gggggctggg gagaacacta agaccaacct     3540

ggaatctatc ctgagctacc ccaaggactt cacctgtgtg caccaggccc tgaagggctt     3600

caccaccaag ggggtgacct ctgtgagcca gatcttccac agccctgacc tggccatcag     3660

ggatactttt gtgaatgcca gcagaaccct gtactcttct agccccaggg tgctgagcaa     3720

taattctgat gctaacctgg agctgatcaa tacctgggtg gctaagaata ccaacaacaa     3780

gattagcagg ctgctggact ctctgccttc tgataccagg ctggtgctgc tgaatgccat     3840

ttacctgtct gccaagtgga agaccacttt tgaccctaag aagactagga tggagccttt     3900

ccacttcaag aactctgtca ttaaggtgcc catgatgaac agcaagaagt atcctgtggc     3960

ccactttatt gaccagactc tgaaggccaa ggtgggccag ctgcagctga gccataacct     4020

gagcctggtg atcctggtgc cccagaacct gaagcatagg ctggaggaca tggagcaggc     4080

tctgagcccc tctgtgttca aggctattat ggagaagctg gagatgagca agttccagcc     4140

cactctgctg accctgccca gaatcaaggt gaccacctct caggacatgc tgagcatcat     4200

ggaaaagctg gagttctttg acttttctta tgacctgaat ctgtgtggcc tgactgagga     4260

tcctgatctg caggtgtctg ccatgcagca ccagactgtg ctggagctga ctgagactgg     4320

ggtggaggct gctgctgctt ctgccatctc tgtggccagg accctgctgg tgtttgaggt     4380

gcagcagccc ttcctgtttg tgctgtggga ccagcagcac aagtttcctg tgttcatggg     4440

cagggtgtat gaccccagag cctgacatct agagctgaat tcctgcagcc agggggatca     4500

gcctctactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cttgccttcc     4560

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatca     4620

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     4680

gaggattggg aagacaatag caggcatgct ggggatgcag tgggctctat ggcttctgag     4740

gcagaaagaa ccagctgggg ctcgagatcc actagggccg caggaacccc tagtgatgga     4800

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4860

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca g              4911


<210>  47
<211>  5011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1co21(Intron 3-4)_BGH228

<400>  47
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggtaag accctgcttg aattctctcc     1980

aggtcatttg ttggacactc ccataagagt caccaatcca gacacttaca aagccatgcc     2040

tctgggaaga agctgtaaaa atgggctatt atatattggg ggtggggtag agggatgtat     2100

cttttcattc ttgaacattc catcatttca cagtgatgta ataggcacga ttgcttgtaa     2160

aactctgtga ctatacaaga acatataaaa taaggtcgca gccactaacc atgtttcatg     2220

gcaaggagag gtgataagaa agatgaaatt aggcgcagtg gctcacgcct gtaatcccag     2280

cactttggga ggccaaggcg ggtggatcac ctgaggtcag gagttcaaga ccagcctggc     2340

caacatggtg aaaccctgtc tctactaaaa atacaaaaat tatcagggag tggtggtgca     2400

tgcctgtaat cccagctact tgggcagctg aggcaggaga atcgcttgaa cccaggaggt     2460

ggaggttgca gtgagccgag accgcaccat tgcactacag tctgggtgac agagcgagac     2520

tctgtctcaa aaaaaaaaaa aaattatcag agatagacct agagtagatg tggttagtac     2580

tgccttctag ctctgtgacc ttgggcagat cactttaacc tctctgagcc ttgagtcctc     2640

ttgtgtaaaa tagtgatgat gctatctacc tcaaaagatt aagaagcaga aagccaggcc     2700

ggatgcggtg gttcacacct gtaatcccag cattttagga ggccgaggcg ggcagatcac     2760

gaggtcagga gttcgagacc agcctgacta acatggtgaa accccgtctc tactaaaaat     2820

aaaaagaaat tagctaggca tggtggtgca cacctgtaac cccagctact caggaggctg     2880

aggcaggaga atcacttgaa cacgggaggc agaggttgca gtgagccgaa atcatgccac     2940

tgcactccag cctgggaaga ctgagcaaga ctctgtctca aaaaaaaaaa agaagcagcc     3000

tagtgtctga cttagtggga ggtcaaaaaa atgtaaatcc tctgccatct tgagggatta     3060

ctgtcaagtc ccatttggta attaccctag gaatggcaca aacaaattac tacaagcagt     3120

ggggacagag ctattactcc ccagagagaa ttctaaaaag gctacagaat ctttcttggc     3180

tgggcacggt gactcacacc tataatcctg gcactttggg aggccaaggc aggagttcaa     3240

gaccagcctg gccaacatgt tgaaacccca tctctactaa aaatgcaaaa attagccagg     3300

catagtgatg catgcttatt gtcccagcta cttgggaggc agaggtggga ggattgcttg     3360

aacctggaga ttcaagtgag ctgagattgc accactgcat tccagcctgg gcaacaaagc     3420

aagactctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaag agagattgag agaacacttc     3480

cagctcagat gatctgtgat cccctccaaa gcagggaata ccctccattc cagcctggtc     3540

cccaaccctc attcccaagg aaggcccccg actcatcctg caagtatctt tcatctctgc     3600

cctttgttgc aggggctggg gagaacacta agaccaacct ggaatctatc ctgagctacc     3660

ccaaggactt cacctgtgtg caccaggccc tgaagggctt caccaccaag ggggtgacct     3720

ctgtgagcca gatcttccac agccctgacc tggccatcag ggatactttt gtgaatgcca     3780

gcagaaccct gtactcttct agccccaggg tgctgagcaa taattctgat gctaacctgg     3840

agctgatcaa tacctgggtg gctaagaata ccaacaacaa gattagcagg ctgctggact     3900

ctctgccttc tgataccagg ctggtgctgc tgaatgccat ttacctgtct gccaagtgga     3960

agaccacttt tgaccctaag aagactagga tggagccttt ccacttcaag aactctgtca     4020

ttaaggtgcc catgatgaac agcaagaagt atcctgtggc ccactttatt gaccagactc     4080

tgaaggccaa ggtgggccag ctgcagctga gccataacct gagcctggtg atcctggtgc     4140

cccagaacct gaagcatagg ctggaggaca tggagcaggc tctgagcccc tctgtgttca     4200

aggctattat ggagaagctg gagatgagca agttccagcc cactctgctg accctgccca     4260

gaatcaaggt gaccacctct caggacatgc tgagcatcat ggaaaagctg gagttctttg     4320

acttttctta tgacctgaat ctgtgtggcc tgactgagga tcctgatctg caggtgtctg     4380

ccatgcagca ccagactgtg ctggagctga ctgagactgg ggtggaggct gctgctgctt     4440

ctgccatctc tgtggccagg accctgctgg tgtttgaggt gcagcagccc ttcctgtttg     4500

tgctgtggga ccagcagcac aagtttcctg tgttcatggg cagggtgtat gaccccagag     4560

cctgacatct agagctgaat tcctgcagcc agggggatca gcctctactg tgccttctag     4620

ttgccagcca tctgttgttt gcccctcccc cttgccttcc ttgaccctgg aaggtgccac     4680

tcccactgtc ctttcctaat aaaatgagga aattgcatca cattgtctga gtaggtgtca     4740

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     4800

caggcatgct ggggatgcag tgggctctat ggcttctgag gcagaaagaa ccagctgggg     4860

ctcgagatcc actagggccg caggaacccc tagtgatgga gttggccact ccctctctgc     4920

gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc     4980

gggcggcctc agtgagcgag cgagcgcgca g                                    5011


<210>  48
<211>  4920
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pSwap_ApoE_hAAT_HBB2m1_SERPING1co21.P2A.SERPING1co24_BGH228

<400>  48
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtac      120

taggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt      180

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      240

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      300

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      360

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      420

tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa cagccactaa      480

ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga ctgtctgact      540

cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag gtacaatgac      600

tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta      660

ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg      720

ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt      780

aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga      840

cagtgaatag atcttgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      900

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata      960

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1020

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1080

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1140

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1200

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttct     1260

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcttgttca     1320

tacctcttat cttcctccca cagctcctgg gcaacctgct ggtctctctg ctggcccatc     1380

actttggcaa agcactagtg ccaccatggc ctctaggctg actctgctga ctctgctgct     1440

cctgctgctg gctggggaca gggccagctc taaccccaat gctacttcta gctcctctca     1500

ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg tgatctctaa     1560

gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca acagcaccac     1620

caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc agcccactac     1680

tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc tgcccactga     1740

cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc tgtgctctga     1800

cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact tctctctgaa     1860

gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt ttagcccctt     1920

cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca ctaagaccaa     1980

cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg ccctgaaggg     2040

cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg acctggccat     2100

cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca gggtgctgag     2160

caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga ataccaacaa     2220

caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc tgctgaatgc     2280

catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta ggatggagcc     2340

tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga agtatcctgt     2400

ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc tgagccataa     2460

cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg acatggagca     2520

ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga gcaagttcca     2580

gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat     2640

catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg gcctgactga     2700

ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc tgactgagac     2760

tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc tggtgtttga     2820

ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat     2880

gggcagggtg tatgacccca gagctggctc tggtgccacc aacttctccc tgctcaagca     2940

ggcaggggat gtggaagaga atcctggacc catggctagc aggctgaccc tgctgaccct     3000

gctgctcctg ctgctggctg gggacagggc ctctagcaat cccaatgcca cctctagctc     3060

tagccaggat cctgagagcc tgcaggacag gggggagggc aaggtggcca ccactgtgat     3120

cagcaagatg ctgtttgtgg agcccattct ggaggtgtct tctctgccca ccaccaatag     3180

caccactaat tctgccacca agatcactgc taacaccact gatgagccca ccactcagcc     3240

taccactgag cccaccaccc agcccactat ccagcccacc cagcccacca cccagctgcc     3300

tactgacagc cctacccagc ccactactgg gagcttctgc cctggccctg tgaccctgtg     3360

ctctgacctg gagagccaca gcactgaggc tgtgctgggg gatgccctgg tggacttcag     3420

cctgaagctg taccatgcct tttctgccat gaagaaggtg gagaccaaca tggcctttag     3480

ccctttcagc attgccagcc tgctgactca ggtgctgctg ggggctgggg agaacaccaa     3540

gaccaacctg gagagcatcc tgagctaccc caaggacttc acttgtgtgc accaggccct     3600

gaagggcttc actaccaagg gggtgacttc tgtgagccag atcttccaca gccctgacct     3660

ggccatcagg gatacttttg tgaatgccag caggaccctg tacagcagca gccccagggt     3720

gctgagcaac aactctgatg ctaacctgga gctgatcaat acttgggtgg ccaagaacac     3780

caacaacaag atttctaggc tgctggactc tctgccctct gacactaggc tggtgctgct     3840

gaatgccatc tacctgtctg ccaagtggaa gaccaccttt gatcccaaga agactaggat     3900

ggagcccttc cacttcaaga actctgtgat caaggtgccc atgatgaaca gcaagaagta     3960

ccctgtggcc catttcattg accagaccct gaaggccaag gtggggcagc tgcagctgag     4020

ccacaatctg agcctggtga ttctggtgcc ccagaatctg aagcacagac tggaggacat     4080

ggagcaggct ctgtctccct ctgtgttcaa ggccatcatg gagaagctgg agatgagcaa     4140

gttccagccc actctgctga ctctgcctag gatcaaggtg accaccagcc aggacatgct     4200

gagcattatg gagaagctgg agttctttga cttcagctat gacctgaacc tgtgtggcct     4260

gactgaggac cctgatctgc aggtgtctgc catgcagcac cagactgtgc tggagctgac     4320

tgagactggg gtggaggctg ctgctgcctc tgctatttct gtggccagga ccctgctggt     4380

gtttgaggtg cagcagccct tcctgtttgt gctgtgggac cagcagcaca agtttcctgt     4440

gttcatgggg agggtgtatg accccagggc ctgacatcta gagctgaatt cctgcagcca     4500

gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg cccctccccc     4560

ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     4620

attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     4680

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt gggctctatg     4740

gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc aggaacccct     4800

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     4860

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     4920


<210>  49
<211>  4030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1.Fc_BGH228

<400>  49
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

gctgctggct ggggatagag cctcctcaaa tccaaatgct accagctcca gctcccagga     1500

tccagagagt ttgcaagaca gaggcgaagg gaaggtcgca acaacagtta tctccaagat     1560

gctattcgtt gaacccatcc tggaggtttc cagcttgccg acaaccaact caacaaccaa     1620

ttcagccacc aaaataacag ctaataccac tgatgaaccc accacacaac ccaccacaga     1680

gcccaccacc caacccacca tccaacccac ccaaccaact acccagctcc caacagattc     1740

tcctacccag cccactactg ggtccttctg cccaggacct gttactctct gctctgactt     1800

ggagagtcat tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct     1860

ctaccacgcc ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag     1920

catcgccagc ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct     1980

ggagagcatc ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacgaccaaa ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag     2100

ggacaccttt gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa     2160

caacagtgac gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagccgg ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat     2280

ctacctgagt gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt     2340

tcacttcaaa aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc     2400

ccatttcatt gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct     2460

gagtttggtg atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc     2520

tctcagccct tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc     2580

cactctccta acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat     2640

ggagaaattg gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga     2700

ccctgatctt caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaggcg gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt     2820

gcagcagccc ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg     2880

gcgagtatat gaccccaggg ccgacaaaac tcacacatgc ccaccgtgcc cagcacctga     2940

actcctgggg ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat     3000

ctcccggacc cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt     3060

caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga     3120

ggagcagtac aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg     3180

gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga     3240

gaaaaccatc tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc     3300

atcccgggat gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta     3360

tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac     3420

cacgcctccc gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga     3480

caagagcagg tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca     3540

caaccactac acgcagaaga gcctctccct gtctccgggt tgaagatcta gagctgaatt     3600

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     3660

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     3720

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     3780

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     3840

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     3900

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     3960

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4020

gagcgcgcag                                                            4030


<210>  50
<211>  4030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1.Fc(Ishino)_BGH228

<400>  50
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

gctgctggct ggggatagag cctcctcaaa tccaaatgct accagctcca gctcccagga     1500

tccagagagt ttgcaagaca gaggcgaagg gaaggtcgca acaacagtta tctccaagat     1560

gctattcgtt gaacccatcc tggaggtttc cagcttgccg acaaccaact caacaaccaa     1620

ttcagccacc aaaataacag ctaataccac tgatgaaccc accacacaac ccaccacaga     1680

gcccaccacc caacccacca tccaacccac ccaaccaact acccagctcc caacagattc     1740

tcctacccag cccactactg ggtccttctg cccaggacct gttactctct gctctgactt     1800

ggagagtcat tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct     1860

ctaccacgcc ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag     1920

catcgccagc ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct     1980

ggagagcatc ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacgaccaaa ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag     2100

ggacaccttt gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa     2160

caacagtgac gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagccgg ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat     2280

ctacctgagt gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt     2340

tcacttcaaa aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc     2400

ccatttcatt gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct     2460

gagtttggtg atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc     2520

tctcagccct tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc     2580

cactctccta acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat     2640

ggagaaattg gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga     2700

ccctgatctt caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaggcg gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt     2820

gcagcagccc ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg     2880

gcgagtatat gaccccaggg ccgacaaaac tcacacatgc ccaccgtgcc cagcacctga     2940

actcctgggg ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat     3000

ctcccggacc cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt     3060

caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga     3120

ggagcagtac aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg     3180

gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga     3240

gaaaaccatc tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc     3300

atcccgggat gagctgacca agaaccaggt caatctgacc tgcctggtca aaggcttcta     3360

tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac     3420

cacgcctccc gtgctggact ccgacggctc cttcttcctc aatagcaagc tcaccgtgga     3480

caagagcagg tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca     3540

caaccactac acgcagaaga gcctctccct gtctccgggt tgaagatcta gagctgaatt     3600

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     3660

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     3720

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     3780

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     3840

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     3900

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     3960

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4020

gagcgcgcag                                                            4030


<210>  51
<211>  4030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1.Fc(Ying)_BGH228

<400>  51
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

gctgctggct ggggatagag cctcctcaaa tccaaatgct accagctcca gctcccagga     1500

tccagagagt ttgcaagaca gaggcgaagg gaaggtcgca acaacagtta tctccaagat     1560

gctattcgtt gaacccatcc tggaggtttc cagcttgccg acaaccaact caacaaccaa     1620

ttcagccacc aaaataacag ctaataccac tgatgaaccc accacacaac ccaccacaga     1680

gcccaccacc caacccacca tccaacccac ccaaccaact acccagctcc caacagattc     1740

tcctacccag cccactactg ggtccttctg cccaggacct gttactctct gctctgactt     1800

ggagagtcat tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct     1860

ctaccacgcc ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag     1920

catcgccagc ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct     1980

ggagagcatc ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacgaccaaa ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag     2100

ggacaccttt gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa     2160

caacagtgac gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagccgg ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat     2280

ctacctgagt gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt     2340

tcacttcaaa aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc     2400

ccatttcatt gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct     2460

gagtttggtg atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc     2520

tctcagccct tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc     2580

cactctccta acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat     2640

ggagaaattg gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga     2700

ccctgatctt caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaggcg gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt     2820

gcagcagccc ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg     2880

gcgagtatat gaccccaggg ccgacaaaac tcacacatgc ccaccgtgcc cagcacctga     2940

actcctgggg ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat     3000

ctcccggacc cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt     3060

caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga     3120

ggagcagtac aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg     3180

gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga     3240

gaaaaccatc tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccaagccccc     3300

atcccgggat gagctgacca agaaccaggt cagcctgagc tgcctggtca aaggcttcta     3360

tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac     3420

cacggtgccc gtgctggact ccgacggctc cttcagactc gccagctacc tcaccgtgga     3480

caagagcagg tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca     3540

caaccactac acgcagaaga gcctctccct gtctccgggt tgaagatcta gagctgaatt     3600

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     3660

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     3720

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     3780

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     3840

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     3900

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     3960

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4020

gagcgcgcag                                                            4030


<210>  52
<211>  4030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1.Fc(YTE)_BGH228

<400>  52
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

gctgctggct ggggatagag cctcctcaaa tccaaatgct accagctcca gctcccagga     1500

tccagagagt ttgcaagaca gaggcgaagg gaaggtcgca acaacagtta tctccaagat     1560

gctattcgtt gaacccatcc tggaggtttc cagcttgccg acaaccaact caacaaccaa     1620

ttcagccacc aaaataacag ctaataccac tgatgaaccc accacacaac ccaccacaga     1680

gcccaccacc caacccacca tccaacccac ccaaccaact acccagctcc caacagattc     1740

tcctacccag cccactactg ggtccttctg cccaggacct gttactctct gctctgactt     1800

ggagagtcat tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct     1860

ctaccacgcc ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag     1920

catcgccagc ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct     1980

ggagagcatc ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacgaccaaa ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag     2100

ggacaccttt gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa     2160

caacagtgac gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagccgg ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat     2280

ctacctgagt gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt     2340

tcacttcaaa aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc     2400

ccatttcatt gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct     2460

gagtttggtg atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc     2520

tctcagccct tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc     2580

cactctccta acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat     2640

ggagaaattg gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga     2700

ccctgatctt caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaggcg gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt     2820

gcagcagccc ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg     2880

gcgagtatat gaccccaggg ccgacaaaac tcacacatgc ccaccgtgcc cagcacctga     2940

actcctgggg ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctctacat     3000

cacccgggag cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt     3060

caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga     3120

ggagcagtac aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg     3180

gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga     3240

gaaaaccatc tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc     3300

atcccgggat gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta     3360

tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac     3420

cacgcctccc gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga     3480

caagagcagg tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca     3540

caaccactac acgcagaaga gcctctccct gtctccgggt tgaagatcta gagctgaatt     3600

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     3660

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     3720

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     3780

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     3840

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     3900

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     3960

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4020

gagcgcgcag                                                            4030


<210>  53
<211>  4030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1.Fc(LS)_BGH228

<400>  53
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

gctgctggct ggggatagag cctcctcaaa tccaaatgct accagctcca gctcccagga     1500

tccagagagt ttgcaagaca gaggcgaagg gaaggtcgca acaacagtta tctccaagat     1560

gctattcgtt gaacccatcc tggaggtttc cagcttgccg acaaccaact caacaaccaa     1620

ttcagccacc aaaataacag ctaataccac tgatgaaccc accacacaac ccaccacaga     1680

gcccaccacc caacccacca tccaacccac ccaaccaact acccagctcc caacagattc     1740

tcctacccag cccactactg ggtccttctg cccaggacct gttactctct gctctgactt     1800

ggagagtcat tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct     1860

ctaccacgcc ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag     1920

catcgccagc ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct     1980

ggagagcatc ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacgaccaaa ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag     2100

ggacaccttt gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa     2160

caacagtgac gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagccgg ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat     2280

ctacctgagt gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt     2340

tcacttcaaa aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc     2400

ccatttcatt gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct     2460

gagtttggtg atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc     2520

tctcagccct tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc     2580

cactctccta acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat     2640

ggagaaattg gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga     2700

ccctgatctt caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaggcg gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt     2820

gcagcagccc ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg     2880

gcgagtatat gaccccaggg ccgacaaaac tcacacatgc ccaccgtgcc cagcacctga     2940

actcctgggg ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat     3000

ctcccggacc cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt     3060

caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga     3120

ggagcagtac aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg     3180

gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga     3240

gaaaaccatc tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc     3300

atcccgggat gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta     3360

tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac     3420

cacgcctccc gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga     3480

caagagcagg tggcagcagg ggaacgtctt ctcatgctcc gtgctgcatg aggctctgca     3540

cagccactac acgcagaaga gcctctccct gtctccgggt tgaagatcta gagctgaatt     3600

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     3660

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     3720

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     3780

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     3840

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     3900

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     3960

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4020

gagcgcgcag                                                            4030


<210>  54
<211>  4030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   pAAV_ApoE_hAAT_HBB2m1_SERPING1.Fc(IFL)_BGH228

<400>  54
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcctgc ggcctagtag      120

gctcagaggc acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc      180

atcctccagc agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta      240

ctcatgtccc taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      300

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc      360

caacatccac tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg      420

tttaggtagt gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga      480

ttctgcagtg agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac      540

gccaccccct ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc      600

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc      660

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt      720

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa      780

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag      840

tgaatagatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      900

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acacatattg      960

accaaatcag ggtaattttg catttgtaat tttaaaaaat gctttcttct tttaatatac     1020

ttttttgttt atcttatttc taatactttc cctaatctct ttctttcagg gcaataatga     1080

tacaatgtat catgcctctt tgcaccattc taaagaataa cagtgataat ttctgggtta     1140

aggcaatagc aatatttctg catataaata tttctgcata taaattgtaa ctgatgtaag     1200

aggtttcata ttgctaatag cagctacaat ccagctacca ttctgctttt attttctggt     1260

tgggataagg ctggattatt ctgagtccaa gctaggccct tttgctaatc ttgttcatac     1320

ctcttatctt cctcccacag ctcctgggca acctgctggt ctctctgctg gcccatcact     1380

ttggcaaagc acgcgtgcca ccatggcctc caggctgacc ctgctgaccc tcctgctgct     1440

gctgctggct ggggatagag cctcctcaaa tccaaatgct accagctcca gctcccagga     1500

tccagagagt ttgcaagaca gaggcgaagg gaaggtcgca acaacagtta tctccaagat     1560

gctattcgtt gaacccatcc tggaggtttc cagcttgccg acaaccaact caacaaccaa     1620

ttcagccacc aaaataacag ctaataccac tgatgaaccc accacacaac ccaccacaga     1680

gcccaccacc caacccacca tccaacccac ccaaccaact acccagctcc caacagattc     1740

tcctacccag cccactactg ggtccttctg cccaggacct gttactctct gctctgactt     1800

ggagagtcat tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct     1860

ctaccacgcc ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag     1920

catcgccagc ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct     1980

ggagagcatc ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt     2040

cacgaccaaa ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag     2100

ggacaccttt gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa     2160

caacagtgac gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa     2220

gatcagccgg ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat     2280

ctacctgagt gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt     2340

tcacttcaaa aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc     2400

ccatttcatt gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct     2460

gagtttggtg atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc     2520

tctcagccct tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc     2580

cactctccta acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat     2640

ggagaaattg gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga     2700

ccctgatctt caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg     2760

ggtggaggcg gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt     2820

gcagcagccc ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg     2880

gcgagtatat gaccccaggg ccgacaaaac tcacacatgc ccaccgtgcc cagcacctga     2940

actcctgggg ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat     3000

ctcccggacc cctgagatca catgcgtggt ggtggacgtg agccacgaag accctgaggt     3060

caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga     3120

ggagcagtac aacagcacgt accgtgtggt cagcgtcctc accttcctgc accaggactg     3180

gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga     3240

gaaaaccatc tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc     3300

atcccgggat gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta     3360

tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac     3420

cacgcctccc gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga     3480

caagagcagg tggcagcagg ggaacgtctt ctcatgctcc gtgctgcatg aggctctgca     3540

caaccactac acgcagaaga gcctctccct gtctccgggt tgaagatcta gagctgaatt     3600

cctgcagcca gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg     3660

cccctccccc ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     3720

aaatgaggaa attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt     3780

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt     3840

gggctctatg gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc     3900

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     3960

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4020

gagcgcgcag                                                            4030


<210>  55
<211>  3479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_(4x mir-142-3p)_BGH228

<400>  55
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggac agggccagct ctaaccccaa tgctacttct     1500

agctcctctc aggaccctga gagcctgcag gacagggggg agggcaaggt ggccaccact     1560

gtgatctcta agatgctgtt tgtggagccc atcctggagg tgagcagcct gcccaccacc     1620

aacagcacca ccaactctgc cactaagatc actgccaaca ccactgatga gcccaccacc     1680

cagcccacta ctgagcccac cacccagcct actatccagc ccacccagcc cactacccag     1740

ctgcccactg acagccctac ccagcccacc actggcagct tctgccctgg gcctgtgacc     1800

ctgtgctctg acctggagag ccattctact gaggctgtgc tgggggatgc cctggtggac     1860

ttctctctga agctgtacca tgctttctct gccatgaaga aggtggagac taacatggct     1920

tttagcccct tcagcattgc tagcctgctg acccaggtgc tgctgggggc tggggagaac     1980

actaagacca acctggaatc tatcctgagc taccccaagg acttcacctg tgtgcaccag     2040

gccctgaagg gcttcaccac caagggggtg acctctgtga gccagatctt ccacagccct     2100

gacctggcca tcagggatac ttttgtgaat gccagcagaa ccctgtactc ttctagcccc     2160

agggtgctga gcaataattc tgatgctaac ctggagctga tcaatacctg ggtggctaag     2220

aataccaaca acaagattag caggctgctg gactctctgc cttctgatac caggctggtg     2280

ctgctgaatg ccatttacct gtctgccaag tggaagacca cttttgaccc taagaagact     2340

aggatggagc ctttccactt caagaactct gtcattaagg tgcccatgat gaacagcaag     2400

aagtatcctg tggcccactt tattgaccag actctgaagg ccaaggtggg ccagctgcag     2460

ctgagccata acctgagcct ggtgatcctg gtgccccaga acctgaagca taggctggag     2520

gacatggagc aggctctgag cccctctgtg ttcaaggcta ttatggagaa gctggagatg     2580

agcaagttcc agcccactct gctgaccctg cccagaatca aggtgaccac ctctcaggac     2640

atgctgagca tcatggaaaa gctggagttc tttgactttt cttatgacct gaatctgtgt     2700

ggcctgactg aggatcctga tctgcaggtg tctgccatgc agcaccagac tgtgctggag     2760

ctgactgaga ctggggtgga ggctgctgct gcttctgcca tctctgtggc caggaccctg     2820

ctggtgtttg aggtgcagca gcccttcctg tttgtgctgt gggaccagca gcacaagttt     2880

cctgtgttca tgggcagggt gtatgacccc agagcctgac atctagactc cataaagtag     2940

gaaacactac accattccat aaagtaggaa acactacaac cagttccata aagtaggaaa     3000

cactacatca ctccataaag taggaaacac tacactctag agctgaattc ctgcagccag     3060

ggggatcagc ctctactgtg ccttctagtt gccagccatc tgttgtttgc ccctccccct     3120

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa     3180

ttgcatcaca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca     3240

gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcagtg ggctctatgg     3300

cttctgaggc agaaagaacc agctggggct cgagatccac tagggccgca ggaaccccta     3360

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     3420

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag      3479


<210>  56
<211>  3363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV_ApoE_hAAT_HBB2m1_SERPING1co21_BGH228 (-ORFs)

<400>  56
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ggctcagagg cacacaggag tttctgggct caccctgccc ccttccaacc      180

cctcagttcc catcctccag cagctgtttg tgtgctgcct ctgaagtcca cactgaacaa      240

acttcagcct actcatgtcc ctaaaatggg caaacattgc aagcagcaaa cagcaaacac      300

acagccctcc ctgcctgctg accttggagc tggggcagag gtcagagacc tctctgggcc      360

catgccacct ccaacatcca ctcgacccct tggaatttcg gtggagagga gcagaggttg      420

tcctggcgtg gtttaggtag tgtgagaggg gtacccgggg atcttgctac cagtggaaca      480

gccactaagg attctgcagt gagagcagag ggccagctaa gtggtactct cccagagact      540

gtctgactca cgccaccccc tccaccttgg acacaggacg ctgtggtttc tgagccaggt      600

acaatgactc ctttcggtaa gtgcagtgga agctgtacac tgcccaggca aagcgtccgg      660

gcagcgtagg cgggcgactc agatcccagc cagtggactt agcccctgtt tgctcctccg      720

ataactgggg tgaccttggt taatattcac cagcagcctc ccccgttgcc cctctggatc      780

cactgcttaa atacggacga ggacagggcc ctgtctcctc agcttcaggc accaccactg      840

acctgggaca gtgaatagat cctgagaact tcagggtgag tctatgggac ccttgatgtt      900

ttctttcccc ttcttttcta tggttaagtt catgtcatag gaaggggaga agtaacaggg      960

tacacatatt gaccaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc     1020

ttttaatata cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag     1080

ggcaataatg atacaatgta tcatgcctct ttgcaccatt ctaaagaata acagtgataa     1140

tttctgggtt aaggcaatag caatatttct gcatataaat atttctgcat ataaattgta     1200

actgatgtaa gaggtttcat attgctaata gcagctacaa tccagctacc attctgcttt     1260

tattttctgg ttgggataag gctggattat tctgagtcca agctaggccc ttttgctaat     1320

cttgttcata cctcttatct tcctcccaca gctcctgggc aacctgctgg tctctctgct     1380

ggcccatcac tttggcaaag cacgcgtgcc accatggcct ctaggctgac tctgctgact     1440

ctgctgctcc tgctgctggc tggggacagg gccagctcta accccaatgc tacttctagc     1500

tcctctcagg accctgagag cctgcaggac aggggggagg gcaaggtggc caccactgtg     1560

atctctaaga tgctgtttgt ggagcccatc ctggaggtga gcagcctgcc caccaccaac     1620

agcaccacca actctgccac taagatcact gccaacacca ctgatgagcc caccacccag     1680

cccactactg agcccaccac ccagcctact atccagccca cccagcccac tacccagctg     1740

cccactgaca gccctaccca gcccaccact ggcagcttct gccctgggcc tgtgaccctg     1800

tgctcagacc tggagagcca ctctactgag gctgtgctgg gggatgccct ggtggacttc     1860

tctctgaagc tgtatcatgc tttctctgcc atgaagaagg tggagactaa catggctttt     1920

agccccttca gcattgctag cctgctgacc caggtgctgc tgggggctgg ggagaacact     1980

aagaccaacc tggaatctat cctgagctac cccaaggact tcacctgtgt gcaccaggcc     2040

ctgaagggct tcaccaccaa gggggtgacc tctgtgagcc agatcttcca cagccctgac     2100

ctggccatca gggatacttt tgtgaatgcc agcagaaccc tgtactcttc tagccccagg     2160

gtgctgagca ataattctga tgctaacctg gagctgatca atacctgggt ggctaagaat     2220

accaacaaca agattagcag gctgctggac tctctgcctt ctgataccag gctggtgctg     2280

ctgaatgcca tttacctgtc tgccaagtgg aagaccactt ttgaccctaa gaagactagg     2340

atggagcctt tccacttcaa gaactctgtc attaaggtgc ccatgatgaa cagcaagaag     2400

tatcctgtgg cccactttat tgaccagact ctgaaggcca aggtgggcca gctgcagctg     2460

agccacaacc tgagcctggt gatcctggtg ccccagaacc tgaagcacag gctggaggac     2520

atggagcagg ctctgagccc ctctgtgttc aaggctatta tggagaagct ggagatgagc     2580

aagttccagc ccactctgct gaccctgccc agaatcaagg tgaccacctc tcaggacatg     2640

ctgagcatca tggaaaagct ggagttcttt gacttttctt atgacctgaa tctgtgtggc     2700

ctgactgagg atcctgatct gcaggtgtct gccatgcagc accagactgt gctggagctg     2760

actgagactg gggtggaggc tgctgctgct tctgccatct ctgtggccag gaccctgctg     2820

gtgtttgagg tgcagcagcc cttcctgttt gtgctgtggg accagcagca caagtttcct     2880

gtgttcatgg gcagggtgta tgaccccaga gcctgaagat ctagagctga attcctgcag     2940

ccagggggat cagcctctac tgtgccttct agttgccagc catctgttgt ttgcccctcc     3000

cccttgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     3060

gaaattgcat cacattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     3120

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc agtgggctct     3180

atggcttctg aggcagaaag aaccagctgg ggctcgagat ccactagggc cgcaggaacc     3240

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg     3300

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg     3360

cag                                                                   3363


<210>  57
<211>  3400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_SERPING1co21(SERPING1 5'UTR)_BGH228

<400>  57
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatctagtct gcactggagc tgcctggtga ccagaagttt      900

ggagtaggtt tggtgctggg caggggtggg gagtagggtg gaaagcatgg agtgaagagg      960

tctagggagg gggtctcctc acccccgcct tcctgcccgc cttgatctcg ggggtctcta     1020

taggcttgct tccacctggg acttctgcct cctcctaccc cagcccctcc cgcctcaggc     1080

ctgttgtgct cagcccccca ggacctcccc tcccccacgc ctctggcctc attgtttggt     1140

taaagcagga ccccctcccc ctcccaccac ctcccctccg actgaacaga tggacagaga     1200

cccgggccca cggggagagg aagggccagc cggtgccggg aaagggaagc ggtttgggga     1260

aaacaaaaca gagggaggag ccagggagaa ggtggcccca ggagggagga ggagggaatt     1320

cgctaagagg gactggggcc tgagacggaa tgggggcggg ccccgggcgg ggtgggggcc     1380

cctgggctcc cagggtggga gctggctccg aggctggctg gctccgcagg tccgctgacg     1440

tcgccgccca gatggcctct aggctgactc tgctgactct gctgctcctg ctgctggctg     1500

gggacagggc cagctctaac cccaatgcta cttctagctc ctctcaggac cctgagagcc     1560

tgcaggacag gggggagggc aaggtggcca ccactgtgat ctctaagatg ctgtttgtgg     1620

agcccatcct ggaggtgagc agcctgccca ccaccaacag caccaccaac tctgccacta     1680

agatcactgc caacaccact gatgagccca ccacccagcc cactactgag cccaccaccc     1740

agcctactat ccagcccacc cagcccacta cccagctgcc cactgacagc cctacccagc     1800

ccaccactgg cagcttctgc cctgggcctg tgaccctgtg ctctgacctg gagagccatt     1860

ctactgaggc tgtgctgggg gatgccctgg tggacttctc tctgaagctg taccatgctt     1920

tctctgccat gaagaaggtg gagactaaca tggcttttag ccccttcagc attgctagcc     1980

tgctgaccca ggtgctgctg ggggctgggg agaacactaa gaccaacctg gaatctatcc     2040

tgagctaccc caaggacttc acctgtgtgc accaggccct gaagggcttc accaccaagg     2100

gggtgacctc tgtgagccag atcttccaca gccctgacct ggccatcagg gatacttttg     2160

tgaatgccag cagaaccctg tactcttcta gccccagggt gctgagcaat aattctgatg     2220

ctaacctgga gctgatcaat acctgggtgg ctaagaatac caacaacaag attagcaggc     2280

tgctggactc tctgccttct gataccaggc tggtgctgct gaatgccatt tacctgtctg     2340

ccaagtggaa gaccactttt gaccctaaga agactaggat ggagcctttc cacttcaaga     2400

actctgtcat taaggtgccc atgatgaaca gcaagaagta tcctgtggcc cactttattg     2460

accagactct gaaggccaag gtgggccagc tgcagctgag ccataacctg agcctggtga     2520

tcctggtgcc ccagaacctg aagcataggc tggaggacat ggagcaggct ctgagcccct     2580

ctgtgttcaa ggctattatg gagaagctgg agatgagcaa gttccagccc actctgctga     2640

ccctgcccag aatcaaggtg accacctctc aggacatgct gagcatcatg gaaaagctgg     2700

agttctttga cttttcttat gacctgaatc tgtgtggcct gactgaggat cctgatctgc     2760

aggtgtctgc catgcagcac cagactgtgc tggagctgac tgagactggg gtggaggctg     2820

ctgctgcttc tgccatctct gtggccagga ccctgctggt gtttgaggtg cagcagccct     2880

tcctgtttgt gctgtgggac cagcagcaca agtttcctgt gttcatgggc agggtgtatg     2940

accccagagc ctgacatcta gagctgaatt cctgcagcca gggggatcag cctctactgt     3000

gccttctagt tgccagccat ctgttgtttg cccctccccc ttgccttcct tgaccctgga     3060

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcac attgtctgag     3120

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     3180

agacaatagc aggcatgctg gggatgcagt gggctctatg gcttctgagg cagaaagaac     3240

cagctggggc tcgagatcca ctagggccgc aggaacccct agtgatggag ttggccactc     3300

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     3360

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                           3400


<210>  58
<211>  4324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21(Intron 2-3)_BGH228 - 
       SINES_LINES

<400>  58
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggta tgtggtccct tgtgggatgg gggacggggg     1500

tggagacggg aggcgggatg gtgcggggtg cgggcggtgg ctgaggatta acccttcagg     1560

ctccggggaa tgaggagagc tcctcttggg atcattgagt gtgatccttg cacacgcact     1620

cgtagatgta tcaaagcaag agtttgttgt agaaaagagc tgtggggagg agaggtttgg     1680

ctgctgtgac acagacggtg gtcccaggct agggcctgtg aagacaggga agaatggtag     1740

caaacatacg tgggtctggg tgggggtcaa tagcagtgag aggtcccagt ggtctgggag     1800

gtcatggact agaaataagg ctaagaagtg caggatccca ggagaaaggt aggtaggggt     1860

gtgtgtatgt gcgtgtgtgt gtgtgtgcac gcgcaagttg gtatcacata ctcagcgtgc     1920

ctatactact tctctctccc tcccttcctg cctcccttct ttcctccttc cctttcttcg     1980

ttcccttcct aatgtgtact gttttttact gttctaaatc aaggagcaca agttcaaatg     2040

tctgtactag ccaagcaagt gagtcaaaca ggtagatatt tacaggaaat tgcaagaaca     2100

tagataaatg acaacactca gcttcactgt ttggaaaaca acttcctaca gggcagtaat     2160

tggtcagaga ttacagagtc cctgactatc cctcatcttc tgcagagcac attcctgtgc     2220

acccccaccc tcaccctgta ttgccccttc tctgaggaat tagtggtggt ggttctaaga     2280

cagattgctc atctgccgca ctgtcagaaa ttactctctt gtacaggaca ttttccacat     2340

ccacaccttc tcttcctgct ttgagtattt tagaggactg tgcctcgtag taagaaaaaa     2400

atgaaactca gtttcttgaa ccacaggaca gggccagctc taaccccaat gctacttcta     2460

gctcctctca ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg     2520

tgatctctaa gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca     2580

acagcaccac caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc     2640

agcccactac tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc     2700

tgcccactga cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc     2760

tgtgctctga cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact     2820

tctctctgaa gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt     2880

ttagcccctt cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca     2940

ctaagaccaa cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg     3000

ccctgaaggg cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg     3060

acctggccat cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca     3120

gggtgctgag caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga     3180

ataccaacaa caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc     3240

tgctgaatgc catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta     3300

ggatggagcc tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga     3360

agtatcctgt ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc     3420

tgagccataa cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg     3480

acatggagca ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga     3540

gcaagttcca gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca     3600

tgctgagcat catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg     3660

gcctgactga ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc     3720

tgactgagac tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc     3780

tggtgtttga ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc     3840

ctgtgttcat gggcagggtg tatgacccca gagcctgaca tctagagctg aattcctgca     3900

gccaggggga tcagcctcta ctgtgccttc tagttgccag ccatctgttg tttgcccctc     3960

ccccttgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     4020

ggaaattgca tcacattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     4080

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cagtgggctc     4140

tatggcttct gaggcagaaa gaaccagctg gggctcgaga tccactaggg ccgcaggaac     4200

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     4260

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     4320

gcag                                                                  4324


<210>  59
<211>  4020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21(Intron 3-4)_BGH228 - 
       SINES_LINES

<400>  59
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggac agggccagct ctaaccccaa tgctacttct     1500

agctcctctc aggaccctga gagcctgcag gacagggggg agggcaaggt ggccaccact     1560

gtgatctcta agatgctgtt tgtggagccc atcctggagg tgagcagcct gcccaccacc     1620

aacagcacca ccaactctgc cactaagatc actgccaaca ccactgatga gcccaccacc     1680

cagcccacta ctgagcccac cacccagcct actatccagc ccacccagcc cactacccag     1740

ctgcccactg acagccctac ccagcccacc actggcagct tctgccctgg gcctgtgacc     1800

ctgtgctctg acctggagag ccattctact gaggctgtgc tgggggatgc cctggtggac     1860

ttctctctga agctgtacca tgctttctct gccatgaaga aggtggagac taacatggct     1920

tttagcccct tcagcattgc tagcctgctg acccaggtgc tgctgggtaa gaccctgctt     1980

gaattctctc caggtcattt gttggacact cccataagag tcaccaatcc agacacttac     2040

aaagccatgc ctctgggaag aagctgtaaa aatgggctat tatatattgg gggtggggta     2100

gagggatgta tcttttcatt cttgaacatt ccatcatttc acagtgatgt aataggcacg     2160

attgcttgta aaactctgtg actatacaag aacatataaa ataaggtcgc agccactaac     2220

catgtttcat ggcaaggaga ggtgataaga aagatgaaat tattatcaga agaagcagaa     2280

agccagcagc ctagtgtctg acttagtggg aggtcaaaaa aatgtaaatc ctctgccatc     2340

ttgagggatt actgtcaagt cccatttggt aattacccta ggaatggcac aaacaaatta     2400

ctacaagcag tggggacaga gctattactc cccagagaga attctaaaaa ggctacagaa     2460

tctttcttga gagattgaga gaacacttcc agctcagatg atctgtgatc ccctccaaag     2520

cagggaatac cctccattcc agcctggtcc ccaaccctca ttcccaagga aggcccccga     2580

ctcatcctgc aagtatcttt catctctgcc ctttgttgca ggggctgggg agaacactaa     2640

gaccaacctg gaatctatcc tgagctaccc caaggacttc acctgtgtgc accaggccct     2700

gaagggcttc accaccaagg gggtgacctc tgtgagccag atcttccaca gccctgacct     2760

ggccatcagg gatacttttg tgaatgccag cagaaccctg tactcttcta gccccagggt     2820

gctgagcaat aattctgatg ctaacctgga gctgatcaat acctgggtgg ctaagaatac     2880

caacaacaag attagcaggc tgctggactc tctgccttct gataccaggc tggtgctgct     2940

gaatgccatt tacctgtctg ccaagtggaa gaccactttt gaccctaaga agactaggat     3000

ggagcctttc cacttcaaga actctgtcat taaggtgccc atgatgaaca gcaagaagta     3060

tcctgtggcc cactttattg accagactct gaaggccaag gtgggccagc tgcagctgag     3120

ccataacctg agcctggtga tcctggtgcc ccagaacctg aagcataggc tggaggacat     3180

ggagcaggct ctgagcccct ctgtgttcaa ggctattatg gagaagctgg agatgagcaa     3240

gttccagccc actctgctga ccctgcccag aatcaaggtg accacctctc aggacatgct     3300

gagcatcatg gaaaagctgg agttctttga cttttcttat gacctgaatc tgtgtggcct     3360

gactgaggat cctgatctgc aggtgtctgc catgcagcac cagactgtgc tggagctgac     3420

tgagactggg gtggaggctg ctgctgcttc tgccatctct gtggccagga ccctgctggt     3480

gtttgaggtg cagcagccct tcctgtttgt gctgtgggac cagcagcaca agtttcctgt     3540

gttcatgggc agggtgtatg accccagagc ctgacatcta gagctgaatt cctgcagcca     3600

gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg cccctccccc     3660

ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     3720

attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     3780

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt gggctctatg     3840

gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc aggaacccct     3900

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     3960

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     4020


<210>  60
<211>  3770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_SERPING1co21(SERPING1APRE/ 5'UTR)_BGH228

<400>  60
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgagg aataacggag gtgagcaatt tccaaaaagt      900

tcattccttt aaaaactgcg gagcacattt tgtgtacatg ctgtttttat tgttactcat      960

gaagacgcgg gggaagcttt ggttgtgtaa agctgagaac tgcacccaag cttccccgtt     1020

caccccacct accaggggat ttgggctaaa ttcctggcct ggcccacaaa gaagaccaag     1080

cggtcagtcc cattccgtcc catcctgatt tacaggaact cacaccagcg atcaatcttc     1140

cttaatttgt aactgggcag tgtcccgggc cagccaatag ctaagactgc cccccccgca     1200

ccccaccctc cctgaccctg ggggactctc tactcagtct gcactggagc tgcctggtga     1260

ccagaagttt ggagtaggtt tggtgctggg caggggtggg gagtagggtg gaaagcatgg     1320

agtgaagagg tctagggagg gggtctcctc acccccgcct tcctgcccgc cttgatctcg     1380

ggggtctcta taggcttgct tccacctggg acttctgcct cctcctaccc cagcccctcc     1440

cgcctcaggc ctgttgtgct cagcccccca ggacctcccc tcccccacgc ctctggcctc     1500

attgtttggt taaagcagga ccccctcccc ctcccaccac ctcccctccg actgaacaga     1560

tggacagaga cccgggccca cggggagagg aagggccagc cggtgccggg aaagggaagc     1620

ggtttgggga aaacaaaaca gagggaggag ccagggagaa ggtggcccca ggagggagga     1680

ggagggaatt cgctaagagg gactggggcc tgagacggaa tgggggcggg ccccgggcgg     1740

ggtgggggcc cctgggctcc cagggtggga gctggctccg aggctggctg gctccgcagg     1800

tccgctgacg tcgccgccca gatggcctct aggctgactc tgctgactct gctgctcctg     1860

ctgctggctg gggacagggc cagctctaac cccaatgcta cttctagctc ctctcaggac     1920

cctgagagcc tgcaggacag gggggagggc aaggtggcca ccactgtgat ctctaagatg     1980

ctgtttgtgg agcccatcct ggaggtgagc agcctgccca ccaccaacag caccaccaac     2040

tctgccacta agatcactgc caacaccact gatgagccca ccacccagcc cactactgag     2100

cccaccaccc agcctactat ccagcccacc cagcccacta cccagctgcc cactgacagc     2160

cctacccagc ccaccactgg cagcttctgc cctgggcctg tgaccctgtg ctctgacctg     2220

gagagccatt ctactgaggc tgtgctgggg gatgccctgg tggacttctc tctgaagctg     2280

taccatgctt tctctgccat gaagaaggtg gagactaaca tggcttttag ccccttcagc     2340

attgctagcc tgctgaccca ggtgctgctg ggggctgggg agaacactaa gaccaacctg     2400

gaatctatcc tgagctaccc caaggacttc acctgtgtgc accaggccct gaagggcttc     2460

accaccaagg gggtgacctc tgtgagccag atcttccaca gccctgacct ggccatcagg     2520

gatacttttg tgaatgccag cagaaccctg tactcttcta gccccagggt gctgagcaat     2580

aattctgatg ctaacctgga gctgatcaat acctgggtgg ctaagaatac caacaacaag     2640

attagcaggc tgctggactc tctgccttct gataccaggc tggtgctgct gaatgccatt     2700

tacctgtctg ccaagtggaa gaccactttt gaccctaaga agactaggat ggagcctttc     2760

cacttcaaga actctgtcat taaggtgccc atgatgaaca gcaagaagta tcctgtggcc     2820

cactttattg accagactct gaaggccaag gtgggccagc tgcagctgag ccataacctg     2880

agcctggtga tcctggtgcc ccagaacctg aagcataggc tggaggacat ggagcaggct     2940

ctgagcccct ctgtgttcaa ggctattatg gagaagctgg agatgagcaa gttccagccc     3000

actctgctga ccctgcccag aatcaaggtg accacctctc aggacatgct gagcatcatg     3060

gaaaagctgg agttctttga cttttcttat gacctgaatc tgtgtggcct gactgaggat     3120

cctgatctgc aggtgtctgc catgcagcac cagactgtgc tggagctgac tgagactggg     3180

gtggaggctg ctgctgcttc tgccatctct gtggccagga ccctgctggt gtttgaggtg     3240

cagcagccct tcctgtttgt gctgtgggac cagcagcaca agtttcctgt gttcatgggc     3300

agggtgtatg accccagagc ctgacatcta gagctgaatt cctgcagcca gggggatcag     3360

cctctactgt gccttctagt tgccagccat ctgttgtttg cccctccccc ttgccttcct     3420

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcac     3480

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     3540

aggattggga agacaatagc aggcatgctg gggatgcagt gggctctatg gcttctgagg     3600

cagaaagaac cagctggggc tcgagatcca ctagggccgc aggaacccct agtgatggag     3660

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     3720

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                3770


<210>  61
<211>  3735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_(SERPING1 APRE) HBB2m1_SERPING1co21_BGH228

<400>  61
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgagg aataacggag gtgagcaatt tccaaaaagt      900

tcattccttt aaaaactgcg gagcacattt tgtgtacatg ctgtttttat tgttactcat      960

gaagacgcgg gggaagcttt ggttgtgtaa agctgagaac tgcacccaag cttccccgtt     1020

caccccacct accaggggat ttgggctaaa ttcctggcct ggcccacaaa gaagaccaag     1080

cggtcagtcc cattccgtcc catcctgatt tacaggaact cacaccagcg atcaatcttc     1140

cttaatttgt aactgggcag tgtcccgggc cagccaatag ctaagactgc cccccccgca     1200

ccccaccctc cctgaccctg ggggactctc tactctgaga acttcagggt gagtctatgg     1260

gacccttgat gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg     1320

agaagtaaca gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa     1380

aaatgctttc ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat     1440

ctctttcttt cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga     1500

ataacagtga taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg     1560

catataaatt gtaactgatg taagaggttt catattgcta atagcagcta caatccagct     1620

accattctgc ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg     1680

cccttttgct aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc     1740

tggtctctct gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct     1800

gactctgctg actctgctgc tcctgctgct ggctggggac agggccagct ctaaccccaa     1860

tgctacttct agctcctctc aggaccctga gagcctgcag gacagggggg agggcaaggt     1920

ggccaccact gtgatctcta agatgctgtt tgtggagccc atcctggagg tgagcagcct     1980

gcccaccacc aacagcacca ccaactctgc cactaagatc actgccaaca ccactgatga     2040

gcccaccacc cagcccacta ctgagcccac cacccagcct actatccagc ccacccagcc     2100

cactacccag ctgcccactg acagccctac ccagcccacc actggcagct tctgccctgg     2160

gcctgtgacc ctgtgctctg acctggagag ccattctact gaggctgtgc tgggggatgc     2220

cctggtggac ttctctctga agctgtacca tgctttctct gccatgaaga aggtggagac     2280

taacatggct tttagcccct tcagcattgc tagcctgctg acccaggtgc tgctgggggc     2340

tggggagaac actaagacca acctggaatc tatcctgagc taccccaagg acttcacctg     2400

tgtgcaccag gccctgaagg gcttcaccac caagggggtg acctctgtga gccagatctt     2460

ccacagccct gacctggcca tcagggatac ttttgtgaat gccagcagaa ccctgtactc     2520

ttctagcccc agggtgctga gcaataattc tgatgctaac ctggagctga tcaatacctg     2580

ggtggctaag aataccaaca acaagattag caggctgctg gactctctgc cttctgatac     2640

caggctggtg ctgctgaatg ccatttacct gtctgccaag tggaagacca cttttgaccc     2700

taagaagact aggatggagc ctttccactt caagaactct gtcattaagg tgcccatgat     2760

gaacagcaag aagtatcctg tggcccactt tattgaccag actctgaagg ccaaggtggg     2820

ccagctgcag ctgagccata acctgagcct ggtgatcctg gtgccccaga acctgaagca     2880

taggctggag gacatggagc aggctctgag cccctctgtg ttcaaggcta ttatggagaa     2940

gctggagatg agcaagttcc agcccactct gctgaccctg cccagaatca aggtgaccac     3000

ctctcaggac atgctgagca tcatggaaaa gctggagttc tttgactttt cttatgacct     3060

gaatctgtgt ggcctgactg aggatcctga tctgcaggtg tctgccatgc agcaccagac     3120

tgtgctggag ctgactgaga ctggggtgga ggctgctgct gcttctgcca tctctgtggc     3180

caggaccctg ctggtgtttg aggtgcagca gcccttcctg tttgtgctgt gggaccagca     3240

gcacaagttt cctgtgttca tgggcagggt gtatgacccc agagcctgac atctagagct     3300

gaattcctgc agccaggggg atcagcctct actgtgcctt ctagttgcca gccatctgtt     3360

gtttgcccct cccccttgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     3420

taataaaatg aggaaattgc atcacattgt ctgagtaggt gtcattctat tctggggggt     3480

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     3540

gcagtgggct ctatggcttc tgaggcagaa agaaccagct ggggctcgag atccactagg     3600

gccgcaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     3660

tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag     3720

cgagcgagcg cgcag                                                      3735


<210>  62
<211>  3397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_BGH228 (SAA2 5'UTR)

<400>  62
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt agggacccgc agctcagcta cagcacagat     1440

cagccaccat ggcctctagg ctgactctgc tgactctgct gctcctgctg ctggctgggg     1500

acagggccag ctctaacccc aatgctactt ctagctcctc tcaggaccct gagagcctgc     1560

aggacagggg ggagggcaag gtggccacca ctgtgatctc taagatgctg tttgtggagc     1620

ccatcctgga ggtgagcagc ctgcccacca ccaacagcac caccaactct gccactaaga     1680

tcactgccaa caccactgat gagcccacca cccagcccac tactgagccc accacccagc     1740

ctactatcca gcccacccag cccactaccc agctgcccac tgacagccct acccagccca     1800

ccactggcag cttctgccct gggcctgtga ccctgtgctc tgacctggag agccattcta     1860

ctgaggctgt gctgggggat gccctggtgg acttctctct gaagctgtac catgctttct     1920

ctgccatgaa gaaggtggag actaacatgg cttttagccc cttcagcatt gctagcctgc     1980

tgacccaggt gctgctgggg gctggggaga acactaagac caacctggaa tctatcctga     2040

gctaccccaa ggacttcacc tgtgtgcacc aggccctgaa gggcttcacc accaaggggg     2100

tgacctctgt gagccagatc ttccacagcc ctgacctggc catcagggat acttttgtga     2160

atgccagcag aaccctgtac tcttctagcc ccagggtgct gagcaataat tctgatgcta     2220

acctggagct gatcaatacc tgggtggcta agaataccaa caacaagatt agcaggctgc     2280

tggactctct gccttctgat accaggctgg tgctgctgaa tgccatttac ctgtctgcca     2340

agtggaagac cacttttgac cctaagaaga ctaggatgga gcctttccac ttcaagaact     2400

ctgtcattaa ggtgcccatg atgaacagca agaagtatcc tgtggcccac tttattgacc     2460

agactctgaa ggccaaggtg ggccagctgc agctgagcca taacctgagc ctggtgatcc     2520

tggtgcccca gaacctgaag cataggctgg aggacatgga gcaggctctg agcccctctg     2580

tgttcaaggc tattatggag aagctggaga tgagcaagtt ccagcccact ctgctgaccc     2640

tgcccagaat caaggtgacc acctctcagg acatgctgag catcatggaa aagctggagt     2700

tctttgactt ttcttatgac ctgaatctgt gtggcctgac tgaggatcct gatctgcagg     2760

tgtctgccat gcagcaccag actgtgctgg agctgactga gactggggtg gaggctgctg     2820

ctgcttctgc catctctgtg gccaggaccc tgctggtgtt tgaggtgcag cagcccttcc     2880

tgtttgtgct gtgggaccag cagcacaagt ttcctgtgtt catgggcagg gtgtatgacc     2940

ccagagcctg acatctagag ctgaattcct gcagccaggg ggatcagcct ctactgtgcc     3000

ttctagttgc cagccatctg ttgtttgccc ctcccccttg ccttccttga ccctggaagg     3060

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcacatt gtctgagtag     3120

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     3180

caatagcagg catgctgggg atgcagtggg ctctatggct tctgaggcag aaagaaccag     3240

ctggggctcg agatccacta gggccgcagg aacccctagt gatggagttg gccactccct     3300

ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct     3360

ttgcccgggc ggcctcagtg agcgagcgag cgcgcag                              3397


<210>  63
<211>  3508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_BGH228 (SAA2 3' UTR)

<400>  63
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggac agggccagct ctaaccccaa tgctacttct     1500

agctcctctc aggaccctga gagcctgcag gacagggggg agggcaaggt ggccaccact     1560

gtgatctcta agatgctgtt tgtggagccc atcctggagg tgagcagcct gcccaccacc     1620

aacagcacca ccaactctgc cactaagatc actgccaaca ccactgatga gcccaccacc     1680

cagcccacta ctgagcccac cacccagcct actatccagc ccacccagcc cactacccag     1740

ctgcccactg acagccctac ccagcccacc actggcagct tctgccctgg gcctgtgacc     1800

ctgtgctctg acctggagag ccattctact gaggctgtgc tgggggatgc cctggtggac     1860

ttctctctga agctgtacca tgctttctct gccatgaaga aggtggagac taacatggct     1920

tttagcccct tcagcattgc tagcctgctg acccaggtgc tgctgggggc tggggagaac     1980

actaagacca acctggaatc tatcctgagc taccccaagg acttcacctg tgtgcaccag     2040

gccctgaagg gcttcaccac caagggggtg acctctgtga gccagatctt ccacagccct     2100

gacctggcca tcagggatac ttttgtgaat gccagcagaa ccctgtactc ttctagcccc     2160

agggtgctga gcaataattc tgatgctaac ctggagctga tcaatacctg ggtggctaag     2220

aataccaaca acaagattag caggctgctg gactctctgc cttctgatac caggctggtg     2280

ctgctgaatg ccatttacct gtctgccaag tggaagacca cttttgaccc taagaagact     2340

aggatggagc ctttccactt caagaactct gtcattaagg tgcccatgat gaacagcaag     2400

aagtatcctg tggcccactt tattgaccag actctgaagg ccaaggtggg ccagctgcag     2460

ctgagccata acctgagcct ggtgatcctg gtgccccaga acctgaagca taggctggag     2520

gacatggagc aggctctgag cccctctgtg ttcaaggcta ttatggagaa gctggagatg     2580

agcaagttcc agcccactct gctgaccctg cccagaatca aggtgaccac ctctcaggac     2640

atgctgagca tcatggaaaa gctggagttc tttgactttt cttatgacct gaatctgtgt     2700

ggcctgactg aggatcctga tctgcaggtg tctgccatgc agcaccagac tgtgctggag     2760

ctgactgaga ctggggtgga ggctgctgct gcttctgcca tctctgtggc caggaccctg     2820

ctggtgtttg aggtgcagca gcccttcctg tttgtgctgt gggaccagca gcacaagttt     2880

cctgtgttca tgggcagggt gtatgacccc agagcctgac atctagagct tcctcttcac     2940

tctgctctca ggagacctgg ctatgaggcc ctcggggcag ggatacaaag ttagtgaggt     3000

ctatgtccag agaagctgag atatggcata taataggcat ctaataaatg cttaagaggt     3060

ggaatctaga gctgaattcc tgcagccagg gggatcagcc tctactgtgc cttctagttg     3120

ccagccatct gttgtttgcc cctccccctt gccttccttg accctggaag gtgccactcc     3180

cactgtcctt tcctaataaa atgaggaaat tgcatcacat tgtctgagta ggtgtcattc     3240

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     3300

gcatgctggg gatgcagtgg gctctatggc ttctgaggca gaaagaacca gctggggctc     3360

gagatccact agggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3420

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3480

cggcctcagt gagcgagcga gcgcgcag                                        3508


<210>  64
<211>  3540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21_BGH228 (SAA2 5'&3' UTR)

<400>  64
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt agggacccgc agctcagcta cagcacagat     1440

cagccaccat ggcctctagg ctgactctgc tgactctgct gctcctgctg ctggctgggg     1500

acagggccag ctctaacccc aatgctactt ctagctcctc tcaggaccct gagagcctgc     1560

aggacagggg ggagggcaag gtggccacca ctgtgatctc taagatgctg tttgtggagc     1620

ccatcctgga ggtgagcagc ctgcccacca ccaacagcac caccaactct gccactaaga     1680

tcactgccaa caccactgat gagcccacca cccagcccac tactgagccc accacccagc     1740

ctactatcca gcccacccag cccactaccc agctgcccac tgacagccct acccagccca     1800

ccactggcag cttctgccct gggcctgtga ccctgtgctc tgacctggag agccattcta     1860

ctgaggctgt gctgggggat gccctggtgg acttctctct gaagctgtac catgctttct     1920

ctgccatgaa gaaggtggag actaacatgg cttttagccc cttcagcatt gctagcctgc     1980

tgacccaggt gctgctgggg gctggggaga acactaagac caacctggaa tctatcctga     2040

gctaccccaa ggacttcacc tgtgtgcacc aggccctgaa gggcttcacc accaaggggg     2100

tgacctctgt gagccagatc ttccacagcc ctgacctggc catcagggat acttttgtga     2160

atgccagcag aaccctgtac tcttctagcc ccagggtgct gagcaataat tctgatgcta     2220

acctggagct gatcaatacc tgggtggcta agaataccaa caacaagatt agcaggctgc     2280

tggactctct gccttctgat accaggctgg tgctgctgaa tgccatttac ctgtctgcca     2340

agtggaagac cacttttgac cctaagaaga ctaggatgga gcctttccac ttcaagaact     2400

ctgtcattaa ggtgcccatg atgaacagca agaagtatcc tgtggcccac tttattgacc     2460

agactctgaa ggccaaggtg ggccagctgc agctgagcca taacctgagc ctggtgatcc     2520

tggtgcccca gaacctgaag cataggctgg aggacatgga gcaggctctg agcccctctg     2580

tgttcaaggc tattatggag aagctggaga tgagcaagtt ccagcccact ctgctgaccc     2640

tgcccagaat caaggtgacc acctctcagg acatgctgag catcatggaa aagctggagt     2700

tctttgactt ttcttatgac ctgaatctgt gtggcctgac tgaggatcct gatctgcagg     2760

tgtctgccat gcagcaccag actgtgctgg agctgactga gactggggtg gaggctgctg     2820

ctgcttctgc catctctgtg gccaggaccc tgctggtgtt tgaggtgcag cagcccttcc     2880

tgtttgtgct gtgggaccag cagcacaagt ttcctgtgtt catgggcagg gtgtatgacc     2940

ccagagcctg acatctagag cttcctcttc actctgctct caggagacct ggctatgagg     3000

ccctcggggc agggatacaa agttagtgag gtctatgtcc agagaagctg agatatggca     3060

tataataggc atctaataaa tgcttaagag gtggaatcta gagctgaatt cctgcagcca     3120

gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg cccctccccc     3180

ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     3240

attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     3300

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt gggctctatg     3360

gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc aggaacccct     3420

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     3480

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     3540


<210>  65
<211>  4088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT(APRE-SAA2)_HBB2m1_(SAA2 5')SERPING1co21_BGH228

<400>  65
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgggc acgtccccag ctgggctgcc tatttaacgc      900

accacactct cattctccca aggtggggct ccaggactag gctggggcag cagaaagtcc      960

ccctctctac attgtccttg gctcaggagc caacttagaa aaagcatttc caaattggct     1020

aagccagcgg agcagagatt ttctgtgctg agaaatatca ggacatccag aggggtggaa     1080

ggaggcttcc agggcacaca tgagatgtgg caggggtagg ctgtccgttt taaagcttaa     1140

agctttagac atgaactcac agggatttca gtcagggtca tctgccatgt ggcccagcag     1200

ggcccatcct gaggaaatga ccggtatagt caggagctgg ctgaagagct gccctcactc     1260

cacaccttcc agcagcccag gtgccgccat cacggggctc ccactggcat ctctgcagct     1320

gcacttcccc caatgctgag gagcagagct gatctagcac cctgtccatt gccaaggcac     1380

agcaaacctc tcttgttccc ataggttaca caactgggat aaatgacccg ggatgaagaa     1440

accaccggca tccaggaact tgtcttagac cagtttgtag gggaaatgac ctgcagggac     1500

tttccccagg gaccacatcc agcttttctt ccctcccaag agaccagcaa ggctctgaga     1560

acttcagggt gagtctatgg gacccttgat gttttctttc cccttctttt ctatggttaa     1620

gttcatgtca taggaagggg agaagtaaca gggtacacat attgaccaaa tcagggtaat     1680

tttgcatttg taattttaaa aaatgctttc ttcttttaat atactttttt gtttatctta     1740

tttctaatac tttccctaat ctctttcttt cagggcaata atgatacaat gtatcatgcc     1800

tctttgcacc attctaaaga ataacagtga taatttctgg gttaaggcaa tagcaatatt     1860

tctgcatata aatatttctg catataaatt gtaactgatg taagaggttt catattgcta     1920

atagcagcta caatccagct accattctgc ttttattttc tggttgggat aaggctggat     1980

tattctgagt ccaagctagg cccttttgct aatcttgttc atacctctta tcttcctccc     2040

acagctcctg ggcaacctgc tggtctctct gctggcccat cactttggca aagcactagt     2100

gagggacccg cagctcagct acagcacaga tcagccacca tggcctctag gctgactctg     2160

ctgactctgc tgctcctgct gctggctggg gacagggcca gctctaaccc caatgctact     2220

tctagctcct ctcaggaccc tgagagcctg caggacaggg gggagggcaa ggtggccacc     2280

actgtgatct ctaagatgct gtttgtggag cccatcctgg aggtgagcag cctgcccacc     2340

accaacagca ccaccaactc tgccactaag atcactgcca acaccactga tgagcccacc     2400

acccagccca ctactgagcc caccacccag cctactatcc agcccaccca gcccactacc     2460

cagctgccca ctgacagccc tacccagccc accactggca gcttctgccc tgggcctgtg     2520

accctgtgct ctgacctgga gagccattct actgaggctg tgctggggga tgccctggtg     2580

gacttctctc tgaagctgta ccatgctttc tctgccatga agaaggtgga gactaacatg     2640

gcttttagcc ccttcagcat tgctagcctg ctgacccagg tgctgctggg ggctggggag     2700

aacactaaga ccaacctgga atctatcctg agctacccca aggacttcac ctgtgtgcac     2760

caggccctga agggcttcac caccaagggg gtgacctctg tgagccagat cttccacagc     2820

cctgacctgg ccatcaggga tacttttgtg aatgccagca gaaccctgta ctcttctagc     2880

cccagggtgc tgagcaataa ttctgatgct aacctggagc tgatcaatac ctgggtggct     2940

aagaatacca acaacaagat tagcaggctg ctggactctc tgccttctga taccaggctg     3000

gtgctgctga atgccattta cctgtctgcc aagtggaaga ccacttttga ccctaagaag     3060

actaggatgg agcctttcca cttcaagaac tctgtcatta aggtgcccat gatgaacagc     3120

aagaagtatc ctgtggccca ctttattgac cagactctga aggccaaggt gggccagctg     3180

cagctgagcc ataacctgag cctggtgatc ctggtgcccc agaacctgaa gcataggctg     3240

gaggacatgg agcaggctct gagcccctct gtgttcaagg ctattatgga gaagctggag     3300

atgagcaagt tccagcccac tctgctgacc ctgcccagaa tcaaggtgac cacctctcag     3360

gacatgctga gcatcatgga aaagctggag ttctttgact tttcttatga cctgaatctg     3420

tgtggcctga ctgaggatcc tgatctgcag gtgtctgcca tgcagcacca gactgtgctg     3480

gagctgactg agactggggt ggaggctgct gctgcttctg ccatctctgt ggccaggacc     3540

ctgctggtgt ttgaggtgca gcagcccttc ctgtttgtgc tgtgggacca gcagcacaag     3600

tttcctgtgt tcatgggcag ggtgtatgac cccagagcct gacatctaga gctgaattcc     3660

tgcagccagg gggatcagcc tctactgtgc cttctagttg ccagccatct gttgtttgcc     3720

cctccccctt gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa     3780

atgaggaaat tgcatcacat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg     3840

ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg gatgcagtgg     3900

gctctatggc ttctgaggca gaaagaacca gctggggctc gagatccact agggccgcag     3960

gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc     4020

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga     4080

gcgcgcag                                                              4088


<210>  66
<211>  3719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_(2x ADRES)ApoE_hAAT_HBB2m1_SERPING1co21_BGH228

<400>  66
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctgcgcaaag tcaacacaag cctctccacc gtgtgtccat gtttatgtgt      180

atgcgctgtg ccccgtcatg ccacctggac gcagggactc cagtgacctc tccttgcaca      240

agcctctgct ggtttgggaa agattggcat gacatcagcc aagctctggc cttgcctttt      300

ttccctgcgc aaagtcaaca caagcctctc caccgtgtgt ccatgtttat gtgtatgcgc      360

tgtgccccgt catgccacct ggacgcaggg actccagtga cctctccttg cacaagcctc      420

tgctggtttg ggaaagattg gcatgacatc agccaagctc tggccttgcc ttttttccct      480

agtactaggc tcagaggcac acaggagttt ctgggctcac cctgccccct tccaacccct      540

cagttcccat cctccagcag ctgtttgtgt gctgcctctg aagtccacac tgaacaaact      600

tcagcctact catgtcccta aaatgggcaa acattgcaag cagcaaacag caaacacaca      660

gccctccctg cctgctgacc ttggagctgg ggcagaggtc agagacctct ctgggcccat      720

gccacctcca acatccactc gaccccttgg aatttcggtg gagaggagca gaggttgtcc      780

tggcgtggtt taggtagtgt gagaggggta cccggggatc ttgctaccag tggaacagcc      840

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      900

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      960

atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca     1020

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata     1080

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1140

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1200

tgggacagtg aatagatctt gagaacttca gggtgagtct atgggaccct tgatgttttc     1260

tttccccttc ttttctatgg ttaagttcat gtcataggaa ggggagaagt aacagggtac     1320

acatattgac caaatcaggg taattttgca tttgtaattt taaaaaatgc tttcttcttt     1380

taatatactt ttttgtttat cttatttcta atactttccc taatctcttt ctttcagggc     1440

aataatgata caatgtatca tgcctctttg caccattcta aagaataaca gtgataattt     1500

ctgggttaag gcaatagcaa tatttctgca tataaatatt tctgcatata aattgtaact     1560

gatgtaagag gtttcatatt gctaatagca gctacaatcc agctaccatt ctgcttttat     1620

tttctggttg ggataaggct ggattattct gagtccaagc taggcccttt tgctaatctt     1680

gttcatacct cttatcttcc tcccacagct cctgggcaac ctgctggtct ctctgctggc     1740

ccatcacttt ggcaaagcac tagtgccacc atggcctcta ggctgactct gctgactctg     1800

ctgctcctgc tgctggctgg ggacagggcc agctctaacc ccaatgctac ttctagctcc     1860

tctcaggacc ctgagagcct gcaggacagg ggggagggca aggtggccac cactgtgatc     1920

tctaagatgc tgtttgtgga gcccatcctg gaggtgagca gcctgcccac caccaacagc     1980

accaccaact ctgccactaa gatcactgcc aacaccactg atgagcccac cacccagccc     2040

actactgagc ccaccaccca gcctactatc cagcccaccc agcccactac ccagctgccc     2100

actgacagcc ctacccagcc caccactggc agcttctgcc ctgggcctgt gaccctgtgc     2160

tctgacctgg agagccattc tactgaggct gtgctggggg atgccctggt ggacttctct     2220

ctgaagctgt accatgcttt ctctgccatg aagaaggtgg agactaacat ggcttttagc     2280

cccttcagca ttgctagcct gctgacccag gtgctgctgg gggctgggga gaacactaag     2340

accaacctgg aatctatcct gagctacccc aaggacttca cctgtgtgca ccaggccctg     2400

aagggcttca ccaccaaggg ggtgacctct gtgagccaga tcttccacag ccctgacctg     2460

gccatcaggg atacttttgt gaatgccagc agaaccctgt actcttctag ccccagggtg     2520

ctgagcaata attctgatgc taacctggag ctgatcaata cctgggtggc taagaatacc     2580

aacaacaaga ttagcaggct gctggactct ctgccttctg ataccaggct ggtgctgctg     2640

aatgccattt acctgtctgc caagtggaag accacttttg accctaagaa gactaggatg     2700

gagcctttcc acttcaagaa ctctgtcatt aaggtgccca tgatgaacag caagaagtat     2760

cctgtggccc actttattga ccagactctg aaggccaagg tgggccagct gcagctgagc     2820

cataacctga gcctggtgat cctggtgccc cagaacctga agcataggct ggaggacatg     2880

gagcaggctc tgagcccctc tgtgttcaag gctattatgg agaagctgga gatgagcaag     2940

ttccagccca ctctgctgac cctgcccaga atcaaggtga ccacctctca ggacatgctg     3000

agcatcatgg aaaagctgga gttctttgac ttttcttatg acctgaatct gtgtggcctg     3060

actgaggatc ctgatctgca ggtgtctgcc atgcagcacc agactgtgct ggagctgact     3120

gagactgggg tggaggctgc tgctgcttct gccatctctg tggccaggac cctgctggtg     3180

tttgaggtgc agcagccctt cctgtttgtg ctgtgggacc agcagcacaa gtttcctgtg     3240

ttcatgggca gggtgtatga ccccagagcc tgacatctag agctgaattc ctgcagccag     3300

ggggatcagc ctctactgtg ccttctagtt gccagccatc tgttgtttgc ccctccccct     3360

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa     3420

ttgcatcaca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca     3480

gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcagtg ggctctatgg     3540

cttctgaggc agaaagaacc agctggggct cgagatccac tagggccgca ggaaccccta     3600

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     3660

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag      3719


<210>  67
<211>  3382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21(+RIDD1x)_BGH228

<400>  67
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggac agggccagct ctaaccccaa tgctacttct     1500

agctcctctc aggaccctga gagcctgcag gacagggggg agggcaaggt ggccaccact     1560

gtgatctcta agatgctgtt tgtggagccc atcctggagg tgagcagcct gcccaccacc     1620

aacagcacca ccaactctgc cactaagatc actgccaaca ccactgatga gcccaccacc     1680

cagcccacta ctgagcccac cacccagcct actatccagc ccacccagcc cactacccag     1740

ctgcccactg acagccctac ccagcccacc actggcagct tctgccctgg gcctgtgacc     1800

ctgtgctctg acctggagag ccattctact gaggctgtgc tgggggatgc cctggtggac     1860

ttctctctga agctgtacca tgctttctct gccatgaaga aggtggagac taacatggct     1920

tttagcccct tcagcattgc tagcctgctg acccaggtgc tgctgggggc tggggagaac     1980

actaagacca acctggaatc tatcctgagc taccccaagg acttcacctg tgtgcaccag     2040

gccctgaagg gcttcaccac caagggggtg acctctgtga gccagatctt ccacagccct     2100

gacctggcca tcagggatac ttttgtgaat gccagcagaa ccctgtactc ttctagcccc     2160

agggtgctga gcaataattc tgatgctaac ctggagctga tcaatacctg ggtggctaag     2220

aataccaaca acaagattag caggctgctg gactctctgc cttctgatac caggctggtg     2280

ctgctgaatg ccatttacct gtctgccaag tggaagacca cttttgaccc taagaagact     2340

aggatggagc ctttccactt caagaactct gtcattaagg tgcccatgat gaacagcaag     2400

aagtatcctg tggcccactt tattgaccag actctgaagg ccaaggtggg ccagctgcag     2460

ctgagccata acctgagcct ggtgatcctg gtgccccaga acctgaagca taggctggag     2520

gacatggagc aggctctgag cccctctgtg ttcaaggcta ttatggagaa gctggagatg     2580

agcaagttcc agcccactct gctgaccctg cccagaatca aggtgaccac ctctcaggac     2640

atgctgagca tcatggaaaa gctggagttc tttgactttt cttatgacct gaatctgtgt     2700

ggcctgactg aggatcctga tctgcaggtg tctgccatgc agcaccagac tgtgctggag     2760

ctgactgaga ctggggtgga ggctgctgct gcttctgcca tctctgtggc caggaccctg     2820

ctggtgtttg aggtgcagca gcccttcctg tttgtgctgt gggaccagca gcacaagttt     2880

cctgtgttca tgggcagggt gtatgacccc agagcctgac atctagagca cctctgcagc     2940

aggtctagaa ttcctgcagc cagggggatc agcctctact gtgccttcta gttgccagcc     3000

atctgttgtt tgcccctccc ccttgccttc cttgaccctg gaaggtgcca ctcccactgt     3060

cctttcctaa taaaatgagg aaattgcatc acattgtctg agtaggtgtc attctattct     3120

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     3180

tggggatgca gtgggctcta tggcttctga ggcagaaaga accagctggg gctcgagatc     3240

cactagggcc gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3300

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3360

cagtgagcga gcgagcgcgc ag                                              3382


<210>  68
<211>  3415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21(+RIDD3x)_BGH228

<400>  68
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggac agggccagct ctaaccccaa tgctacttct     1500

agctcctctc aggaccctga gagcctgcag gacagggggg agggcaaggt ggccaccact     1560

gtgatctcta agatgctgtt tgtggagccc atcctggagg tgagcagcct gcccaccacc     1620

aacagcacca ccaactctgc cactaagatc actgccaaca ccactgatga gcccaccacc     1680

cagcccacta ctgagcccac cacccagcct actatccagc ccacccagcc cactacccag     1740

ctgcccactg acagccctac ccagcccacc actggcagct tctgccctgg gcctgtgacc     1800

ctgtgctctg acctggagag ccattctact gaggctgtgc tgggggatgc cctggtggac     1860

ttctctctga agctgtacca tgctttctct gccatgaaga aggtggagac taacatggct     1920

tttagcccct tcagcattgc tagcctgctg acccaggtgc tgctgggggc tggggagaac     1980

actaagacca acctggaatc tatcctgagc taccccaagg acttcacctg tgtgcaccag     2040

gccctgaagg gcttcaccac caagggggtg acctctgtga gccagatctt ccacagccct     2100

gacctggcca tcagggatac ttttgtgaat gccagcagaa ccctgtactc ttctagcccc     2160

agggtgctga gcaataattc tgatgctaac ctggagctga tcaatacctg ggtggctaag     2220

aataccaaca acaagattag caggctgctg gactctctgc cttctgatac caggctggtg     2280

ctgctgaatg ccatttacct gtctgccaag tggaagacca cttttgaccc taagaagact     2340

aggatggagc ctttccactt caagaactct gtcattaagg tgcccatgat gaacagcaag     2400

aagtatcctg tggcccactt tattgaccag actctgaagg ccaaggtggg ccagctgcag     2460

ctgagccata acctgagcct ggtgatcctg gtgccccaga acctgaagca taggctggag     2520

gacatggagc aggctctgag cccctctgtg ttcaaggcta ttatggagaa gctggagatg     2580

agcaagttcc agcccactct gctgaccctg cccagaatca aggtgaccac ctctcaggac     2640

atgctgagca tcatggaaaa gctggagttc tttgactttt cttatgacct gaatctgtgt     2700

ggcctgactg aggatcctga tctgcaggtg tctgccatgc agcaccagac tgtgctggag     2760

ctgactgaga ctggggtgga ggctgctgct gcttctgcca tctctgtggc caggaccctg     2820

ctggtgtttg aggtgcagca gcccttcctg tttgtgctgt gggaccagca gcacaagttt     2880

cctgtgttca tgggcagggt gtatgacccc agagcctgac atctagagca cctctgcagc     2940

aggaagtctc tgcagaagat aacacctgca gagtggtcta gaattcctgc agccaggggg     3000

atcagcctct actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccttgcc     3060

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     3120

atcacattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     3180

gggggaggat tgggaagaca atagcaggca tgctggggat gcagtgggct ctatggcttc     3240

tgaggcagaa agaaccagct ggggctcgag atccactagg gccgcaggaa cccctagtga     3300

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg     3360

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcag          3415


<210>  69
<211>  3382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21(+RIDD1xBlos)_BGH228

<400>  69
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggac agggccagct ctaaccccaa tgctacttct     1500

agctcctctc aggaccctga gagcctgcag gacagggggg agggcaaggt ggccaccact     1560

gtgatctcta agatgctgtt tgtggagccc atcctggagg tgagcagcct gcccaccacc     1620

aacagcacca ccaactctgc cactaagatc actgccaaca ccactgatga gcccaccacc     1680

cagcccacta ctgagcccac cacccagcct actatccagc ccacccagcc cactacccag     1740

ctgcccactg acagccctac ccagcccacc actggcagct tctgccctgg gcctgtgacc     1800

ctgtgctctg acctggagag ccattctact gaggctgtgc tgggggatgc cctggtggac     1860

ttctctctga agctgtacca tgctttctct gccatgaaga aggtggagac taacatggct     1920

tttagcccct tcagcattgc tagcctgctg acccaggtgc tgctgggggc tggggagaac     1980

actaagacca acctggaatc tatcctgagc taccccaagg acttcacctg tgtgcaccag     2040

gccctgaagg gcttcaccac caagggggtg acctctgtga gccagatctt ccacagccct     2100

gacctggcca tcagggatac ttttgtgaat gccagcagaa ccctgtactc ttctagcccc     2160

agggtgctga gcaataattc tgatgctaac ctggagctga tcaatacctg ggtggctaag     2220

aataccaaca acaagattag caggctgctg gactctctgc cttctgatac caggctggtg     2280

ctgctgaatg ccatttacct gtctgccaag tggaagacca cttttgaccc taagaagact     2340

aggatggagc ctttccactt caagaactct gtcattaagg tgcccatgat gaacagcaag     2400

aagtatcctg tggcccactt tattgaccag actctgaagg ccaaggtggg ccagctgcag     2460

ctgagccata acctgagcct ggtgatcctg gtgccccaga acctgaagca taggctggag     2520

gacatggagc aggctctgag cccctctgtg ttcaaggcta ttatggagaa gctggagatg     2580

agcaagttcc agcccactct gctgaccctg cccagaatca aggtgaccac ctctcaggac     2640

atgctgagca tcatggaaaa gctggagttc tttgactttt cttatgacct gaatctgtgt     2700

ggcctgactg aggatcctga tctgcaggtg tctgccatgc agcaccagac tgtgctggag     2760

ctgactgaga ctggggtgga ggctgctgct gcttctgcca tctctgtggc caggaccctg     2820

ctggtgtttg aggtgcagca gcccttcctg tttgtgctgt gggaccagca gcacaagttt     2880

cctgtgttca tgggcagggt gtatgacccc agagcctgac atctagagca cctctgcagc     2940

aggtctagaa ttcctgcagc cagggggatc agcctctact gtgccttcta gttgccagcc     3000

atctgttgtt tgcccctccc ccttgccttc cttgaccctg gaaggtgcca ctcccactgt     3060

cctttcctaa taaaatgagg aaattgcatc acattgtctg agtaggtgtc attctattct     3120

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     3180

tggggatgca gtgggctcta tggcttctga ggcagaaaga accagctggg gctcgagatc     3240

cactagggcc gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3300

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3360

cagtgagcga gcgagcgcgc ag                                              3382


<210>  70
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV 5' ITR (AAV2 ITR 5')

<400>  70
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcct                   108


<210>  71
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV 3' ITR (AAV ITR 3')

<400>  71
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  72
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSWAP 5' ITR

<400>  72
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcggcc tcagtgagcg       60

agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcct                   108


<210>  73
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSWAP 3' ITR

<400>  73
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  74
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ApoE Enhancer

<400>  74
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg g                                                321


<210>  75
<211>  641
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2xApoE

<400>  75
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgg      300

gtttaggtag tgtgagaggg aggctcagag gcacacagga gtttctgggc tcaccctgcc      360

cccttccaac ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc      420

acactgaaca aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa      480

acagcaaaca cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac      540

ctctctgggc ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg      600

agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg g                          641


<210>  76
<211>  1283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4xApoE

<400>  76
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgg      300

gtttaggtag tgtgagaggg aggctcagag gcacacagga gtttctgggc tcaccctgcc      360

cccttccaac ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc      420

acactgaaca aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa      480

acagcaaaca cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac      540

ctctctgggc ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg      600

agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg gaggctcaga ggcacacagg      660

agtttctggg ctcaccctgc ccccttccaa cccctcagtt cccatcctcc agcagctgtt      720

tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc ctactcatgt ccctaaaatg      780

ggcaaacatt gcaagcagca aacagcaaac acacagccct ccctgcctgc tgaccttgga      840

gctggggcag aggtcagaga cctctctggg cccatgccac ctccaacatc cactcgaccc      900

cttggaattt cggtggagag gagcagaggt tgtcctggcg tggtttaggt agtgtgagag      960

ggaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca acccctcagt     1020

tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa caaacttcag     1080

cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa cacacagccc     1140

tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg gcccatgcca     1200

cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg ttgtcctggc     1260

gtggtttagg tagtgtgaga ggg                                             1283


<210>  77
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SAA2 APRE

<400>  77
tgggcacgtc cccagctggg ctgcctattt aacgcaccac actctcattc tcccaaggtg       60

gggctccagg actaggctgg ggcagcagaa agtccccctc tctacattgt ccttggctca      120

ggagccaact tagaaaaagc atttccaaat tggctaagcc agcggagcag agattttctg      180

tgctgagaaa tatcaggaca tccagagggg tggaaggagg cttccagggc acacatgaga      240

tgtggcaggg gtaggctgtc cgttttaaag cttaaagctt tagacatgaa ctcacaggga      300

tttcagtcag ggtcatctgc catgtggccc agcagggccc atcctgagga aatgaccggt      360

atagtcagga gctggctgaa gagctgccct cactccacac cttccagcag cccaggtgcc      420

gccatcacgg ggctcccact ggcatctctg cagctgcact tcccccaatg ctgaggagca      480

gagctgatct agcaccctgt ccattgccaa ggcacagcaa acctctcttg ttcccatagg      540

ttacacaact gggataaatg acccgggatg aagaaaccac cggcatccag gaacttgtct      600

tagaccagtt tgtaggggaa atgacctgca gggactttcc ccagggacca catccagctt      660

ttcttccctc ccaagagacc agcaaggctc                                       690


<210>  78
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2x ADRES

<400>  78
gcgcaaagtc aacacaagcc tctccaccgt gtgtccatgt ttatgtgtat gcgctgtgcc       60

ccgtcatgcc acctggacgc agggactcca gtgacctctc cttgcacaag cctctgctgg      120

tttgggaaag attggcatga catcagccaa gctctggcct tgcctttttt ccctgcgcaa      180

agtcaacaca agcctctcca ccgtgtgtcc atgtttatgt gtatgcgctg tgccccgtca      240

tgccacctgg acgcagggac tccagtgacc tctccttgca caagcctctg ctggtttggg      300

aaagattggc atgacatcag ccaagctctg gccttgcctt ttttccct                   348


<210>  79
<211>  397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAAT promoter

<400>  79
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agtgaat                               397


<210>  80
<211>  392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAATv18

<400>  80
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc agccaccccc tccaccttgg acacaggatg      120

ctgtggtttc tgagccaggt acaatgactc ctttggtaag tgcagtggaa gctgtacact      180

gcccaggcaa aggtctgggc aggtaggggg tgactcagat cccagccagt ggacttagcc      240

cctgtttgct cctctgataa ctggggtgac cttggttaat attcaccagc agcctcccct      300

gttgcccctc tggatccact gcttaaatat ggatgaggac agggccctgt ctcctcagct      360

tcaggcacca ccactgacct gggacagtga at                                    392


<210>  81
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBB2m1 intron

<400>  81
gatcctgaga acttcagggt gagtctatgg gacccttgat gttttctttc cccttctttt       60

ctatggttaa gttcatgtca taggaagggg agaagtaaca gggtacacat attgaccaaa      120

tcagggtaat tttgcatttg taattttaaa aaatgctttc ttcttttaat atactttttt      180

gtttatctta tttctaatac tttccctaat ctctttcttt cagggcaata atgatacaat      240

gtatcatgcc tctttgcacc attctaaaga ataacagtga taatttctgg gttaaggcaa      300

tagcaatatt tctgcatata aatatttctg catataaatt gtaactgatg taagaggttt      360

catattgcta atagcagcta caatccagct accattctgc ttttattttc tggttgggat      420

aaggctggat tattctgagt ccaagctagg cccttttgct aatcttgttc atacctctta      480

tcttcctccc acagctcctg ggcaacctgc tggtctctct gctggcccat cactttggca      540

aag                                                                    543


<210>  82
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBB2m1(-ATG)

<400>  82
gatcctgaga acttcagggt gagtctttgg gacccttgtt gttttctttc cccttctttt       60

ctttggttaa gttcttgtca taggaagggg agaagtaaca gggtacacat attgaccaaa      120

tcagggtaat tttgcatttg taattttaaa aattgctttc ttcttttaat atactttttt      180

gtttatctta tttctaatac tttccctaat ctctttcttt cagggcaata ttgatacatt      240

gtatcttgcc tctttgcacc attctaaaga ataacagtga taatttctgg gttaaggcaa      300

tagcaatatt tctgcatata aatatttctg catataaatt gtaactgttg taagaggttt      360

catattgcta atagcagcta caatccagct accattctgc ttttattttc tggttgggat      420

aaggctggat tattctgagt ccaagctagg cccttttgct aatcttgttc atacctctta      480

tcttcctccc acagctcctg ggcaacctgc tggtctctct gctggcccat cactttggca      540

aag                                                                    543


<210>  83
<211>  228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGH228 polyA

<400>  83
ctactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccttg ccttccttga       60

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcacatt      120

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg      180

attgggaaga caatagcagg catgctgggg atgcagtggg ctctatgg                   228


<210>  84
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1-WT Signal peptide

<400>  84
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctca                                                                  66


<210>  85
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sp7 Signal peptide variant

<400>  85
atggcctttc tgtggctgct gtcctgctgg gccctgctgg ggaccacctt tggc             54


<210>  86
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sp7 Signal peptide variant

<400>  86
atggccttcc tgtggctgct gtcctgctgg gcactgctgg gcaccacatt tggc             54


<210>  87
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sp7 Signal peptide variant

<400>  87
atggccttcc tgtggctgct gagctgctgg gccctgctgg ggaccacctt tggg             54


<210>  88
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sp7 Signal peptide variant

<400>  88
atggccttcc tgtggctcct gagctgctgg gccctcctgg ggaccacctt tggg             54


<210>  89
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sp7 Signal peptide variant

<400>  89
atggccttcc tgtggctgct gagctgctgg gccctgctgg ggaccacatt tggc             54


<210>  90
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALB Signal peptide

<400>  90
atgaagtggg taacctttat ttcccttctt tttctcttta gctcggctta ttcc             54


<210>  91
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ORM1 Signal peptide

<400>  91
atggcgctgt cctgggttct tacagtcctg agcctcctac ctctgctgga agcc             54


<210>  92
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TF Signal peptide

<400>  92
atgaggctcg ccgtgggagc cctgctggtc tgcgccgtcc tggggctgtg tctggct          57


<210>  93
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AMPB Signal peptide

<400>  93
atgaggagcc tcggggccct gctcttgctg ctgagcgcct gcctggcggt gagcgct          57


<210>  94
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LAMP1 Signal peptide

<400>  94
atggcggccc ccggcagcgc ccggcgaccc ctgctgctgc tactgctgtt gctgctgctc       60

ggcctcatgc attgtgcgtc agca                                              84


<210>  95
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BTN2A2 Signal peptide

<400>  95
atggaaccag ctgctgctct gcacttctcc ctgccagcct ccctcctcct cctcctgctc       60

ctcctccttc tcagcctgtg tgcactggtc tcagcc                                 96


<210>  96
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD300A Signal peptide

<400>  96
atgtggctgc cttgggctct gttgcttctc tgggtcccag gatgttttgc t                51


<210>  97
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NOTCH2 Signal peptide

<400>  97
atgcccgccc tgcgccccgc tctgctgtgg gcgctgctgg cgctctggct gtgctgcgcg       60

gcccccgcgc atgca                                                        75


<210>  98
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STRC Signal peptide

<400>  98
atggctctca gcctctggcc cctgctgctg ctgctgctgc tgctgctgct gctgtccttt       60

gca                                                                     63


<210>  99
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AHSG Signal peptide

<400>  99
atgaagtccc tcgtcctgct cctttgtctt gctcagctct ggggctgcca ctca             54


<210>  100
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syn1 Signal peptide

<400>  100
atgaagttcg ccctggtggc cgccctggcc ctgctgctgt tcctgtggag cagctgcagg       60

gcc                                                                     63


<210>  101
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syn2 Signal peptide

<400>  101
atgaagttcg ccctggtggc cgccctggcc ctgctgctgt tcctgtgggg ctgccacagc       60


<210>  102
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syn3 Signal peptide

<400>  102
atgaagtggg tgaccctgct gaccctgctg ctgctgctgc tgttcctgtg gggctgccac       60

agc                                                                     63


<210>  103
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syn4 Signal peptide

<400>  103
atgaagtggg tgaccctgct gaccctgctg ctgctgctgc tgttcctgtg gagcagctgc       60

agggcc                                                                  66


<210>  104
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1-WT

<400>  104
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

tga                                                                   1503


<210>  105
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI2

<400>  105
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgctac ctctagctct agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac caccaactct actaccaact ctgctaccaa gatcactgcc      240

aataccactg atgaacccac cactcagccc actactgagc ccaccaccca gcccaccatt      300

cagcccactc agcccactac ccagctgcct actgactctc ccacccagcc caccactggc      360

agcttttgtc ctggccctgt gaccctgtgc tctgacctgg agagccattc tactgaggct      420

gtgctggggg atgccctggt ggacttcagc ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg agaccaacat ggccttcagc cccttctcta ttgcctctct gctgacccag      540

gtgctgctgg gggctgggga gaatactaag accaacctgg agagcattct gagctatccc      600

aaggacttca cctgtgtgca ccaggccctg aaggggttca ctactaaagg ggtgacctct      660

gtgtctcaga tcttccacag ccctgacctg gccatcaggg acacttttgt gaatgccagc      720

aggaccctgt acagcagcag ccccagagtg ctgagcaata attctgatgc taatctggag      780

ctgattaaca cttgggtggc caagaacacc aacaacaaga tctctaggct gctggattct      840

ctgccctctg acaccaggct ggtgctgctg aatgccatct atctgtctgc caagtggaag      900

accacctttg atcccaagaa gaccaggatg gagcccttcc atttcaagaa ctctgtgatt      960

aaagtgccca tgatgaactc taagaagtat cctgtggccc acttcattga tcagactctg     1020

aaggccaagg tggggcagct gcagctgagc cacaacctga gcctggtgat cctggtgccc     1080

cagaatctga agcacaggct ggaggacatg gagcaggccc tgagcccctc tgtgttcaag     1140

gccatcatgg agaagctgga gatgagcaag ttccagccca ccctgctgac tctgcccaga     1200

attaaggtga ccaccagcca ggacatgctg agcatcatgg agaagctgga gttctttgac     1260

ttctcttatg acctgaacct gtgtggcctg actgaggatc ctgacctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gccatttctg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gtttcctgtg tttatgggca gggtgtatga ccctagggcc     1500

tga                                                                   1503


<210>  106
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI3

<400>  106
atggccagca ggctgaccct gctgactctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgccac ctccagcagc agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggctac tactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac cactaactct actactaatt ctgccactaa gatcactgcc      240

aataccactg atgagccaac cactcagccc accactgagc ccaccaccca gcccaccatt      300

cagcccactc agcctaccac ccagctgcct actgacagcc ccactcagcc cactactggc      360

tctttctgtc ctgggcctgt gactctgtgc tctgacctgg aatcccacag cactgaggct      420

gtgctggggg atgccctggt ggatttcagc ctgaagctgt accatgcttt ctctgccatg      480

aagaaggtgg agaccaacat ggccttcagc cctttctcta ttgccagcct gctgactcag      540

gtgctgctgg gggctgggga gaataccaag accaacctgg agtctatcct gagctatccc      600

aaggacttca cttgtgtgca ccaggccctg aaggggttca ccaccaaggg ggtgacctct      660

gtgtctcaga tctttcacag ccctgacctg gccatcaggg atacctttgt gaatgccagc      720

aggaccctgt acagcagcag ccccagggtg ctgagcaaca actctgatgc caacctggag      780

ctgatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctggacagc      840

ctgccctctg ataccaggct ggtgctgctg aatgccatct acctgtctgc taagtggaag      900

accacttttg atcctaagaa gaccaggatg gagccctttc acttcaagaa ctctgtgatc      960

aaggtgccca tgatgaactc taagaaatac cctgtggccc acttcattga tcagaccctg     1020

aaggccaagg tgggccagct gcagctgagc cacaacctga gcttggtgat cctggtgcct     1080

cagaacctga agcacaggct ggaggacatg gagcaggccc tgagcccctc tgtgttcaag     1140

gccattatgg agaagctgga gatgagcaag ttccagccta ccctgctgac cctgcccagg     1200

atcaaggtga ctactagcca ggatatgctg agcatcatgg agaagctgga gttttttgat     1260

ttcagctatg acctgaacct gtgtggcctg actgaggacc ctgacctgca ggtgtctgcc     1320

atgcagcatc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gccatctctg tggccaggac cctgctggtg tttgaggtgc agcagccttt cctgtttgtg     1440

ctgtgggatc agcagcacaa gtttcctgtg ttcatgggca gggtgtatga ccccagggct     1500

tga                                                                   1503


<210>  107
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI4

<400>  107
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgctac ctctagctct agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac caccaactct actaccaact ctgctaccaa gatcactgcc      240

aataccactg atgaacccac cactcagccc actactgagc ccaccaccca gcccaccatt      300

cagcccactc agcccactac ccagctgcct actgactctc ccacccagcc caccactggg      360

agcttctgtc caggccctgt gactctgtgt tctgacctgg agagccacag cactgaagct      420

gtgctggggg atgctctggt ggacttcagc ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg aaaccaacat ggcctttagc cccttcagca ttgctagcct gctgactcag      540

gtgctgctgg gggctgggga gaacactaag actaacctgg agtctatcct gtcttatccc      600

aaggacttca cctgtgtgca tcaggccctg aaggggttca ccaccaaggg ggtcacctct      660

gtgagccaga tctttcacag ccctgatctg gccatcaggg acacctttgt gaatgcctct      720

aggactctgt acagcagcag ccccagggtg ctgagcaaca actctgatgc caacctggag      780

ctgatcaaca cctgggtggc caagaacact aacaacaaga tcagcaggct gctggacagc      840

ctgccctctg acactaggct ggtgctgctg aatgccatct atctgtctgc caagtggaag      900

accacctttg accccaagaa gactaggatg gagccctttc attttaagaa ctctgtgatc      960

aaggtgccca tgatgaacag caagaaatac cctgtggccc atttcattga ccagactctg     1020

aaggctaagg tgggccagct gcagctgagc cacaacctga gcctggtgat cctggtgcca     1080

cagaatctga agcacaggct ggaggacatg gagcaggctc tgtctccctc tgtgttcaag     1140

gccatcatgg agaagctgga gatgtctaag ttccagccca ccctgctgac cctgcccagg     1200

atcaaggtga ccacttctca ggacatgctg tctatcatgg agaagctgga gttttttgac     1260

ttttcttatg acctgaacct gtgtggcctg actgaggacc ctgatctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcttct     1380

gccatttctg tggctaggac tctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtg ttcatgggca gggtgtatga tcccagggct     1500

tga                                                                   1503


<210>  108
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI5

<400>  108
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgctac ctctagctct agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac caccaactct actaccaact ctgctaccaa gatcactgcc      240

aataccactg atgaacccac cactcagccc actactgagc ccaccaccca gcccaccatt      300

cagcccactc agcccactac ccagctgcct actgactctc ccacccagcc caccactggc      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg agagccacag cactgaggct      420

gtgctggggg atgccctggt ggacttcagc ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg agaccaatat ggccttcagc cccttcagca ttgcctctct gctgacccag      540

gtgctgctgg gggctgggga gaacactaag actaacctgg agtctatcct gagctacccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ctaccaaggg ggtcacctct      660

gtgagccaga tcttccatag ccctgacctg gccatcaggg acacctttgt gaatgcctct      720

agaaccctgt actcttcttc tcccagggtg ctgagcaaca attctgatgc caacctggag      780

ctgatcaaca cctgggtggc taagaacact aacaacaaga tcagcaggct gctggacagc      840

ctgccttctg acaccaggct ggtgctgctg aatgccatct atctgtctgc caagtggaag      900

accacttttg accccaagaa gaccaggatg gagcccttcc atttcaagaa ctctgtgatc      960

aaggtcccca tgatgaattc taagaagtac cctgtggctc atttcattga tcagaccctg     1020

aaggccaagg tgggccagct gcagctgagc cacaatctga gcctggtgat cctggtgcct     1080

cagaacctga agcacaggct ggaagacatg gagcaggccc tgagcccctc tgtgtttaag     1140

gccatcatgg agaagctgga gatgtctaag ttccagccca ccctgctgac cctgcccagg     1200

atcaaggtga ccaccagcca ggacatgctg agcatcatgg agaagctgga gttctttgat     1260

ttcagctatg acctgaatct gtgtggcctg actgaggacc ctgatctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggaactgact gagactgggg tggaagctgc tgctgcctct     1380

gccatctctg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtg tttatgggca gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  109
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI6

<400>  109
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgctac ctctagctct agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac caccaactct actaccaact ctgctaccaa gatcactgcc      240

aataccactg atgaacccac cactcagccc actactgagc ccaccaccca gcccaccatt      300

cagcccactc agcccactac ccagctgcct actgactctc ccacccagcc caccactggc      360

tctttctgcc ctgggcctgt gactctgtgc tctgacctgg agagccactc tactgaggct      420

gtgctggggg atgccctggt ggattttagc ctgaagctgt atcatgcctt ctctgccatg      480

aagaaggtgg agaccaacat ggccttcagc cctttcagca ttgccagcct gttgactcag      540

gtgctgctgg gggctgggga gaacaccaag accaatctgg agagcatcct gagctatccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccactaaggg ggtgacctct      660

gtgagccaga ttttccacag ccctgacctg gccattaggg acacctttgt gaatgcttct      720

aggaccctgt actctagctc tcccagggtg ctgagcaaca attctgatgc caacctggag      780

ctgatcaata cttgggtggc caagaacacc aacaacaaga tctctaggct gctggacagc      840

ctgccctctg acaccaggct ggtgctgctg aatgccatct acctgtctgc caagtggaag      900

accacttttg accctaagaa gactaggatg gagcccttcc actttaagaa ctctgtgatt      960

aaggtgccta tgatgaatag caagaagtac cctgtggccc actttattga tcagaccctg     1020

aaggctaagg tgggccagtt gcagctgtct cacaacctga gcctggtgat tctggtgccc     1080

cagaacctga agcataggct ggaggacatg gagcaggccc tgagcccttc tgtgttcaag     1140

gccatcatgg agaagctgga gatgagcaag ttccagccca ccctgctgac cctgcccagg     1200

atcaaggtga ctactagcca ggacatgctg tctatcatgg agaagctgga gttctttgat     1260

ttctcttatg acctgaacct gtgtggcctg actgaggacc cagacctgca ggtgtctgcc     1320

atgcagcatc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gccatctctg tggccaggac tttgctggtg tttgaggtgc agcagccttt cctgtttgtg     1440

ctgtgggatc agcagcacaa gttccctgtg ttcatgggga gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  110
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI7

<400>  110
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgctac ctctagctct agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac caccaactct actaccaact ctgctaccaa gatcactgcc      240

aataccactg atgaacccac cactcagccc actactgagc ccaccaccca gcccaccatt      300

cagcccactc agcccactac ccagctgcct actgactctc ccacccagcc caccactggc      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg agagccattc tactgaggct      420

gtgctggggg atgccctggt ggatttcagc ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg agaccaacat ggccttctct cccttcagca ttgccagcct gctgacccag      540

gtgctgctgg gggctgggga gaacaccaag accaacctgg agagcatcct gtcttacccc      600

aaggacttca cctgtgtgca tcaggccctg aagggcttca ctactaaggg ggtgacctct      660

gtgtctcaga ttttccacag ccctgacctg gctattaggg acacttttgt gaatgcttct      720

aggaccctgt acagcagctc tcccagggtg ctgagcaaca actctgatgc caacctggag      780

ctgattaaca cttgggtggc caagaacact aacaataaga tcagcaggct gctggacagc      840

ctgccctctg acaccaggct ggtgctgctg aatgccatct acctgtctgc caagtggaag      900

actacttttg atcctaagaa gaccaggatg gagcctttcc acttcaagaa ctctgtgatc      960

aaggtgccca tgatgaattc taagaagtac cctgtggctc acttcattga ccagaccctg     1020

aaggccaagg tgggccagct gcagctgagc cacaacctga gcctggtgat tctggtgccc     1080

cagaacctga agcacaggct ggaggacatg gagcaggccc tgagcccctc tgtgttcaag     1140

gccatcatgg agaagctgga gatgagcaag ttccagccta ctctgctgac tctgcccagg     1200

atcaaggtga ccactagcca ggacatgctg agcattatgg agaagctgga gttctttgac     1260

ttttcttatg atctgaacct gtgtggcctg actgaggacc ctgacctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gccatctctg tggctaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggca gggtgtatga tcccagggct     1500

tga                                                                   1503


<210>  111
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI8

<400>  111
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgctac ctctagctct agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac caccaactct actaccaact ctgctaccaa gatcactgcc      240

aataccactg atgaacccac cactcagccc actactgagc ccaccaccca gcccaccatt      300

cagcccactc agcccactac ccagctgcct actgactctc ccacccagcc caccactggc      360

agcttttgcc ctggccctgt gaccctgtgc tctgacctgg agagccacag cactgaggct      420

gtgttggggg atgccctggt ggatttcagc ctgaagctgt accatgcctt ctctgctatg      480

aagaaggtgg agaccaacat ggctttcagc cccttcagca ttgccagcct gctgacccag      540

gtgctgctgg gggctgggga gaacaccaag accaacctgg agagcattct gtcttacccc      600

aaggacttca cctgtgtgca ccaggccctg aaggggttca ctaccaaggg ggtgacctct      660

gtgtctcaga tctttcacag ccctgatctg gccattaggg acacttttgt gaatgctagc      720

aggaccctgt acagctcttc tcccagggtg ctgagcaata actctgatgc caatctggag      780

ctgatcaata cttgggtggc caagaacacc aacaataaga tctctaggct gctggacagc      840

ctgccttctg acaccaggct ggtgctgctg aatgccatct atctgtctgc caagtggaag      900

accacctttg accccaagaa gaccaggatg gagcccttcc actttaagaa ctctgtcatc      960

aaggtgccca tgatgaattc taagaagtac cctgtggccc acttcattga tcagaccctg     1020

aaggccaagg tggggcagct gcagctgagc cacaatctgt ctctggtgat cctggtgccc     1080

cagaatctga agcataggct ggaagacatg gagcaggccc tgagcccctc tgtgttcaag     1140

gccattatgg agaagctgga gatgagcaag ttccagccta ccctgctgac cctgccaagg     1200

atcaaggtga ccaccagcca ggacatgctg agcatcatgg agaagctgga gttctttgac     1260

ttttcttatg acctgaacct gtgtggcctg actgaggatc cagacctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gctatctctg tggccaggac tctgctggtg tttgaggtgc agcagccctt tctgtttgtg     1440

ctgtgggacc agcagcacaa gtttcctgtg ttcatgggca gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  112
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI11

<400>  112
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgctac ctctagctct agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac caccaactct actaccaact ctgctaccaa gatcactgcc      240

aataccactg atgaacccac cactcagccc actactgagc ccaccaccca gcccaccatt      300

cagcccactc agcccactac ccagctgcct actgactctc ccacccagcc caccactggc      360

tctttctgcc caggccctgt gaccctgtgc tctgacctgg agagccactc tactgaggct      420

gtcctggggg atgctctggt ggatttcagc ctgaagctgt atcatgcctt ctctgctatg      480

aagaaggtgg agaccaacat ggccttcagc cccttcagca ttgccagcct gctgacccag      540

gtgctgctgg gggctgggga gaatactaag actaacctgg agagcatcct gagctacccc      600

aaggacttta cctgtgtgca tcaggccctg aagggcttca ccaccaaggg ggtgacctct      660

gtgagccaga tctttcactc tcctgacctg gccatcaggg atacctttgt gaatgccagc      720

aggaccctgt acagctctag ccctagggtg ctgagcaaca attctgatgc caatctggag      780

ctgatcaata cctgggtggc caaaaacacc aacaacaaga tcagcaggct gctggattct      840

ctgccctctg ataccaggct ggtgctgctg aatgctattt acctgtctgc taagtggaag      900

accacctttg accccaagaa gactaggatg gagcctttcc acttcaagaa ctctgtgatc      960

aaggtgccca tgatgaactc taagaagtac cctgtggccc atttcattga ccagaccctg     1020

aaggccaagg tgggccagct gcagctgagc cacaatctga gcctggtgat cctggtgccc     1080

cagaacctga agcataggct ggaggatatg gagcaggccc tgagcccttc tgtgtttaag     1140

gccattatgg agaagctgga gatgtctaag tttcagccca ctctgctgac tctgcccagg     1200

attaaggtga ccaccagcca ggacatgctg agcatcatgg agaagctgga gttctttgac     1260

ttctcttatg acctgaatct gtgtggcctg actgaggacc cagacctgca ggtgtctgct     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcttct     1380

gccatctctg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa attccctgtg ttcatgggca gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  113
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI12

<400>  113
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgctac ctctagctct agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac caccaactct actaccaact ctgctaccaa gatcactgcc      240

aataccactg atgaacccac cactcagccc actactgagc ccaccaccca gcccaccatt      300

cagcccactc agcccactac ccagctgcct actgactctc ccacccagcc caccactggg      360

agcttctgcc ctgggcctgt gaccctgtgt tctgatctgg agtctcacag cactgaggct      420

gtgctggggg atgccctggt ggactttagc ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg agaccaacat ggccttcagc cccttcagca ttgccagcct gctgacccag      540

gtcctgctgg gggctgggga gaataccaag accaacctgg agtctatcct gagctatcct      600

aaggacttta cctgtgtgca ccaggccctg aaggggttca ccaccaaggg ggtgacctct      660

gtgtctcaga tcttccattc tcctgacctg gccatcaggg atacctttgt gaatgctagc      720

agaactctgt atagcagcag ccctagggtg ctgagcaata actctgatgc taacctggag      780

ctgatcaaca cctgggtggc taagaacacc aataacaaga tcagcagact gctggacagc      840

ctgccctctg acactaggct ggtgctgctg aatgccatct acctgtctgc caagtggaag      900

accacctttg atcccaagaa gactaggatg gagcccttcc acttcaagaa ttctgtgatc      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc acttcattga tcagaccctg     1020

aaggccaagg tgggccagct gcagctgtct cacaacctga gcctggtcat cctggtgccc     1080

cagaacctga agcatagact ggaggacatg gagcaggctc tgagcccctc tgtgttcaag     1140

gccattatgg agaagctgga gatgtctaag ttccagccta ctctgctgac cctgcccagg     1200

attaaggtga ccacttctca ggatatgctg agcatcatgg agaagctgga gttttttgac     1260

tttagctatg acctgaacct gtgtggcctg actgaggatc ctgatctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcttct     1380

gccatctctg tggccaggac cttgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggatc agcagcacaa gttccctgtg ttcatgggca gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  114
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI13

<400>  114
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagcaacc ctaatgctac ctctagctct agccaggacc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagca gcctgcccac caccaactct actaccaact ctgctaccaa gatcactgcc      240

aataccactg atgaacccac cactcagccc actactgagc ccaccaccca gcccaccatt      300

cagcccactc agcccactac ccagctgcct actgactctc ccacccagcc caccactggc      360

agcttctgcc ctggccctgt gaccctgtgc tctgacctgg agagccacag cactgaggct      420

gtgctggggg atgccctggt ggatttcagc ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg agaccaacat ggccttcagc cccttcagca ttgctagcct gctgactcag      540

gtgctgctgg gggctgggga gaataccaag accaacctgg agagcatcct gagctatcct      600

aaggacttca cctgtgtgca ccaggccttg aaggggttca ccaccaaggg ggtgacttct      660

gtgagccaga ttttccacag ccctgatctg gctattaggg acacctttgt gaatgccagc      720

aggaccctgt acagctctag ccccagggtg ctgagcaaca actctgatgc taacctggaa      780

ctgatcaaca cttgggtggc taagaacact aataataaga ttagcagact gctggacagc      840

ctgccctctg acaccaggct ggtgctgctg aatgccatct acctgtctgc caagtggaag      900

accacctttg atcccaagaa gaccaggatg gaacccttcc acttcaagaa ttctgtgatt      960

aaggtgccca tgatgaattc taagaagtac cctgtggccc acttcattga tcagaccctg     1020

aaggccaagg tgggccagct gcagctgtct cataatctgt ctctggtgat cctggtgccc     1080

cagaacctga agcataggct ggaggatatg gagcaggccc tgagcccctc tgtcttcaag     1140

gctatcatgg agaagctgga gatgagcaag ttccagccca ccctgctgac cctgcctaga     1200

atcaaggtga ctacttctca ggacatgctg agcatcatgg agaagctgga gttctttgac     1260

ttcagctatg acctgaacct gtgtggcctg actgaggacc ctgacctgca ggtgtctgcc     1320

atgcagcatc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gctatttctg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtg tttatgggca gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  115
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI17

<400>  115
atggcctcta ggctgaccct gctgactctg ctgctcctgc tgctggctgg ggacagggcc       60

tctagcaacc ccaatgctac tagcagcagc agccaggacc ctgaatctct gcaggacagg      120

ggggagggca aggtggccac tactgtgatc tctaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac cactaacagc accactaact ctgccaccaa gatcactgcc      240

aacactactg atgagcccac tactcagccc accactgagc ccactaccca gcccactatc      300

cagcccactc agcccactac ccagctgccc actgacagcc ccacccagcc cactactggc      360

agcttttgcc ctggccctgt gaccctgtgc tctgacctgg agagccactc tactgaggct      420

gtgctggggg atgccctggt ggacttttct ctgaagctgt accatgcctt ttctgccatg      480

aagaaggtgg agactaatat ggccttcagc cccttctcta ttgccagcct gctgactcag      540

gtgctgctgg gggctgggga gaacactaag accaatctgg agagcattct gagctacccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccactaaggg ggtgacctct      660

gtgagccaga tcttccacag ccctgacctg gctatcaggg atacttttgt gaatgccagc      720

aggactctgt acagcagcag ccccagggtg ctgtctaaca actctgatgc taacctggaa      780

ctgatcaaca cttgggtggc caagaacacc aacaacaaga tcagcaggct gctggatagc      840

ctgccctctg acaccagact ggtgctgctg aatgctatct atctgtctgc caagtggaag      900

accacctttg accccaagaa gaccagaatg gagcccttcc atttcaagaa ttctgtgatt      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc acttcattga tcagaccctg     1020

aaggctaagg tgggccagct gcagctgagc cataatctga gcctggtgat cctggtgcct     1080

cagaatctga agcacaggct ggaggacatg gaacaggccc tgagcccctc tgtgttcaag     1140

gctatcatgg aaaagctgga gatgagcaag ttccagccca ctctgctgac cctgcccaga     1200

attaaggtga ctacctctca ggatatgctg agcatcatgg agaagctgga gttttttgac     1260

ttcagctatg atttgaatct gtgtggcctg actgaggatc ctgatctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gccatttctg tggctaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtc     1440

ctgtgggacc agcagcacaa gttccctgtg tttatgggca gagtgtatga ccctagggcc     1500

tga                                                                   1503


<210>  116
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI18

<400>  116
atggctagca ggctgaccct gctgaccctg ctcctgctgc tgctggctgg ggatagggcc       60

agctctaacc ccaatgccac tagcagcagc agccaggacc ctgagtctct gcaggatagg      120

ggggagggca aggtggccac cactgtgatt agcaagatgc tgtttgtgga gcctattctg      180

gaggtgagca gcctgcccac cactaacagc accaccaact ctgccaccaa gatcactgcc      240

aacactactg atgagcctac cactcagccc actactgagc ctaccaccca gcctactatc      300

cagcccaccc agcccaccac ccagctgccc actgatagcc ccactcagcc taccactggc      360

agcttttgcc ctggccctgt gaccctgtgc tctgacctgg agagccatag cactgaggct      420

gtgctggggg atgccctggt ggacttcagc ctgaagctgt accatgcctt ctctgccatg      480

aaaaaggtgg agactaacat ggctttcagc cccttcagca ttgcctctct gctgacccag      540

gtgctgctgg gggctgggga gaacaccaag accaacctgg agagcattct gagctatccc      600

aaagacttca cttgtgtgca tcaggctctg aagggcttta ccaccaaggg ggtgacctct      660

gtgagccaga tcttccatag ccctgacctg gccatcaggg atacctttgt gaatgctagc      720

aggaccctgt acagcagcag ccccagggtg ttgtctaaca actctgatgc taatctggag      780

ctgattaata cttgggtggc caagaacacc aacaataaga tctctaggct gctggatagc      840

ctgccttctg acaccaggct ggtgctgctg aatgccatct atctgtctgc caagtggaag      900

accacttttg atcccaagaa gaccaggatg gagccctttc attttaagaa ctctgtgatc      960

aaggtgccca tgatgaactc taagaagtac cctgtggctc acttcattga ccagaccctg     1020

aaggctaagg tgggccagct gcagctgtct cacaatctgt ctctggtgat cctggtccct     1080

cagaacctga agcacaggct ggaggacatg gagcaggctc tgagcccctc tgtcttcaag     1140

gctatcatgg agaagctgga gatgagcaag ttccagccta ccctgctgac cctgcccagg     1200

atcaaggtga ccacttctca ggacatgctg agcattatgg agaagctgga gttctttgac     1260

ttcagctatg acctgaatct gtgtgggctg actgaggacc ctgacctgca ggtgtctgcc     1320

atgcagcatc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gccatctctg tggccaggac tctgctggtg tttgaggtgc agcagccttt tctgtttgtg     1440

ctgtgggacc agcagcataa gttcccagtg ttcatgggca gggtgtatga tcccagggcc     1500

tga                                                                   1503


<210>  117
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI19

<400>  117
atggccagca ggttgaccct gctgaccctg ctgctcctgc tgctggctgg ggatagggcc       60

agcagcaatc ccaatgctac tagcagcagc agccaggacc ctgagagcct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac taccaactct accaccaact ctgctactaa gatcactgct      240

aatactactg atgagcccac cactcagccc accactgagc ccaccaccca gcccactatc      300

cagcccaccc agcccaccac ccagctgccc actgacagcc ccactcagcc taccactggc      360

tctttctgcc ctggccctgt gaccctgtgt tctgatctgg agagccatag cactgaggct      420

gtgctggggg atgctctggt ggacttcagc ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg agactaacat ggcctttagc cccttttcta ttgccagcct gctgactcag      540

gtgctgctgg gggctgggga gaataccaag accaacctgg agagcatcct gagctacccc      600

aaggacttca cctgtgtgca tcaggctctg aagggcttca ctactaaggg ggtgacctct      660

gtgagccaga tcttccacag ccctgacctg gccattaggg acacctttgt caatgccagc      720

aggactctgt attctagcag ccccagggtg ctgagcaaca actctgatgc caacctggag      780

ctgatcaaca cctgggtggc caagaacact aacaacaaga ttagcaggct gctggacagc      840

ctgccctctg acactaggtt ggtgctgctg aatgccatct acctgtctgc caagtggaag      900

accacctttg atcccaagaa gactaggatg gagcctttcc acttcaagaa ctctgtgatc      960

aaggtgccca tgatgaactc taagaagtat cctgtggccc acttcattga ccagaccctg     1020

aaggccaagg tggggcagct gcagctgtct cacaacctga gcctggtgat cctggtcccc     1080

cagaatctga agcataggct ggaggatatg gagcaggccc tgtctccctc tgtgttcaag     1140

gccatcatgg agaagctgga gatgagcaag tttcagccca ccctgctgac cctgcccagg     1200

atcaaggtga ctactagcca ggacatgctg agcatcatgg agaagctgga gttttttgac     1260

ttctcttatg atctgaacct gtgtggcctg actgaggacc ctgacctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gccatctctg tggccaggac tctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcataa gttccctgtg ttcatgggga gggtgtatga tcccagagcc     1500

tga                                                                   1503


<210>  118
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI20

<400>  118
atggccagca ggctgaccct gctgaccctg ctgctgctcc tgctggctgg ggatagggcc       60

agcagcaacc ccaatgctac tagcagcagc agccaggatc ctgagagcct gcaggacaga      120

ggggaaggga aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcctatcctg      180

gaggtgagct ctctgcccac cactaacagc accaccaatt ctgctactaa gatcactgcc      240

aacaccactg atgagcccac cacccagcct accactgagc caactaccca gcccaccatc      300

cagcccaccc agcccaccac tcagctgcct actgattctc ctactcagcc taccactggg      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg agtctcattc tactgaggct      420

gtgctggggg atgccctggt ggacttcagc ctgaagctgt accatgcttt ctctgccatg      480

aagaaggtgg agactaacat ggccttctct cctttctcta ttgccagcct gctgactcag      540

gtgctgctgg gggctgggga gaataccaag actaacctgg agagcatcct gtcttatcct      600

aaggacttca cttgtgtgca tcaggccctg aagggcttca ccaccaaggg ggtgacttct      660

gtgagccaga ttttccacag ccctgacctg gccatcagag acacctttgt gaatgccagc      720

aggaccctgt attctagctc tcccagggtg ctgagcaaca actctgatgc caatctggaa      780

ctgatcaaca cttgggtggc caagaacacc aacaacaaga tcagcaggct gctggatagc      840

ctgccctctg acaccaggct ggtgctgctg aatgccatct acctgtctgc caagtggaag      900

accacctttg accccaagaa gactaggatg gagcccttcc acttcaagaa ctctgtgatc      960

aaggtgccca tgatgaatag caagaagtac cctgtggccc acttcattga ccagaccctg     1020

aaggccaagg tggggcagct gcagctgagc cacaacctga gcctggtgat cctggtgccc     1080

cagaacctga agcacagact ggaggacatg gagcaggccc tgagcccatc tgtgttcaag     1140

gctattatgg agaagctgga gatgtctaag tttcagccta ccctgctgac cctgcccagg     1200

atcaaggtga ctaccagcca ggacatgctg agcatcatgg agaagctgga attctttgac     1260

ttcagctatg atctgaatct gtgtggcctg actgaagacc ctgatttgca ggtgtctgct     1320

atgcagcacc agactgtgct ggaactgact gagactgggg tggaggctgc tgctgcctct     1380

gccatctctg tggccaggac cctgctggtg tttgaggtgc agcagccttt cctgtttgtg     1440

ctgtgggatc agcagcacaa gttccctgtg ttcatgggca gggtgtatga ccctagggct     1500

tga                                                                   1503


<210>  119
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI21

<400>  119
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggacagggcc       60

agctctaacc ccaatgctac ttctagctcc tctcaggacc ctgagagcct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc tctaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac caccaacagc accaccaact ctgccactaa gatcactgcc      240

aacaccactg atgagcccac cacccagccc actactgagc ccaccaccca gcctactatc      300

cagcccaccc agcccactac ccagctgccc actgacagcc ctacccagcc caccactggc      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg agagccattc tactgaggct      420

gtgctggggg atgccctggt ggacttctct ctgaagctgt accatgcttt ctctgccatg      480

aagaaggtgg agactaacat ggcttttagc cccttcagca ttgctagcct gctgacccag      540

gtgctgctgg gggctgggga gaacactaag accaacctgg aatctatcct gagctacccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccaccaaggg ggtgacctct      660

gtgagccaga tcttccacag ccctgacctg gccatcaggg atacttttgt gaatgccagc      720

agaaccctgt actcttctag ccccagggtg ctgagcaata attctgatgc taacctggag      780

ctgatcaata cctgggtggc taagaatacc aacaacaaga ttagcaggct gctggactct      840

ctgccttctg ataccaggct ggtgctgctg aatgccattt acctgtctgc caagtggaag      900

accacttttg accctaagaa gactaggatg gagcctttcc acttcaagaa ctctgtcatt      960

aaggtgccca tgatgaacag caagaagtat cctgtggccc actttattga ccagactctg     1020

aaggccaagg tgggccagct gcagctgagc cataacctga gcctggtgat cctggtgccc     1080

cagaacctga agcataggct ggaggacatg gagcaggctc tgagcccctc tgtgttcaag     1140

gctattatgg agaagctgga gatgagcaag ttccagccca ctctgctgac cctgcccaga     1200

atcaaggtga ccacctctca ggacatgctg agcatcatgg aaaagctgga gttctttgac     1260

ttttcttatg acctgaatct gtgtggcctg actgaggatc ctgatctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcttct     1380

gccatctctg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gtttcctgtg ttcatgggca gggtgtatga ccccagagcc     1500

tga                                                                   1503


<210>  120
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI22

<400>  120
atggcttcta ggctgactct gctgaccctg ctgctgctcc tgctggctgg ggacagggcc       60

tcttctaatc ccaatgccac cagcagcagc tctcaggatc ctgagagcct gcaggatagg      120

ggggagggca aggtggccac tactgtgatc agcaagatgc tgtttgtgga gcccatcctg      180

gaggtgtctt ctctgcccac cactaatagc accactaatt ctgctaccaa gatcactgcc      240

aataccactg atgagcccac cactcagccc actactgagc ctactactca gcccactatc      300

cagcccaccc agcccaccac ccagctgccc actgactctc ccacccagcc cactactggc      360

agcttctgcc ctgggccagt gactctgtgc tctgacctgg agtctcacag cactgaggct      420

gtcctggggg atgccctggt ggatttcagc ttgaagctgt accatgcttt ctctgccatg      480

aagaaggtgg agactaatat ggcttttagc cccttctcta ttgccagcct gctgacccag      540

gtgctgctgg gggctgggga gaatactaag actaacctgg agagcatcct gagctatccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccaccaaggg ggtgacctct      660

gtgagccaga tcttccacag ccctgatctg gctatcaggg acacctttgt gaatgcctct      720

aggactctgt acagcagctc tcccagggtc ctgtctaata actctgatgc caacctggag      780

ctgattaata cttgggtggc caagaatacc aataataaga tcagcaggct gctggacagc      840

ctgccctctg acactaggct ggtgctgctg aatgctattt acctgtctgc caagtggaag      900

accacctttg accccaagaa gaccaggatg gagcctttcc acttcaagaa ttctgtgatc      960

aaggtgccca tgatgaactc taagaagtac cctgtggccc acttcattga ccagactctg     1020

aaggctaagg tgggccagct gcagctgagc cataatctgt ctctggtgat cctggtgcca     1080

cagaacctga agcacaggct ggaggacatg gagcaggccc tgagcccttc tgtgtttaag     1140

gccatcatgg agaagttgga gatgagcaag ttccagccca ccctgctgac cctgcccaga     1200

atcaaggtga ctaccagcca ggacatgctg agcatcatgg agaagctgga gttctttgac     1260

ttcagctatg acctgaacct gtgtggcctg actgaggacc ctgacctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gccatctctg tggccaggac cctgctggtg tttgaggtgc agcagccttt cctgtttgtg     1440

ctgtgggacc agcagcacaa gtttcctgtg ttcatgggca gagtctatga tcccagagct     1500

tga                                                                   1503


<210>  121
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI23

<400>  121
atggccagca ggctgactct gctgaccctg ctcctgctgc tgctggctgg ggacagggcc       60

agctctaacc ccaatgccac ctctagctct agccaggacc ctgagagcct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcccattctg      180

gaggtgagca gcctgcccac caccaacagc accaccaact ctgccaccaa gatcactgcc      240

aataccactg atgagcccac cactcagcct accactgagc ccaccaccca gcctaccatc      300

cagcccaccc agcccactac ccagctgcct actgactctc ccactcagcc cactactggc      360

agcttctgtc cagggcctgt cactctgtgt tctgatctgg agagccacag cactgaggct      420

gtgctggggg atgctctggt ggatttctct ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg agactaacat ggctttcagc cccttctcta ttgcctctct gctgactcag      540

gtcctgctgg gggctgggga aaataccaag actaatctgg agtctatcct gagctatccc      600

aaggacttca cctgtgtgca ccaggctctg aagggcttca ccaccaaggg ggtgacctct      660

gtgtctcaga tcttccatag ccctgacctg gccattaggg acacctttgt gaatgcctct      720

aggaccctgt acagcagcag ccctagggtg ctgagcaaca actctgatgc caatctggag      780

ctgattaaca cctgggtggc caagaatacc aacaacaaga tcagcaggct gctggatagc      840

ctgccttctg ataccaggct ggtgctgttg aatgccatct atctgtctgc caagtggaag      900

actacctttg accctaagaa gaccaggatg gagcccttcc atttcaagaa ttctgtgatc      960

aaggtgccca tgatgaatag caagaaatac cctgtggctc acttcattga ccagaccctg     1020

aaggctaagg tgggccagct gcagctgtct cataacctga gcctggtgat cctggtgccc     1080

cagaacctga agcataggct ggaggacatg gagcaggccc tgagcccctc tgtgtttaag     1140

gccatcatgg agaagctgga gatgagcaag ttccagccca ctctgctgac tctgcccagg     1200

atcaaggtga ccaccagcca ggacatgctg tctatcatgg agaagctgga gttttttgat     1260

ttctcttatg acctgaatct gtgtgggctg actgaggacc ctgacctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gctatctctg tggccaggac cctgctggtg tttgaggtgc agcagccttt cctgtttgtg     1440

ctgtgggacc agcagcataa gttccctgtc ttcatgggca gggtgtatga tcccagagcc     1500

tga                                                                   1503


<210>  122
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI24

<400>  122
atggctagca ggctgaccct gctgaccctg ctgctcctgc tgctggctgg ggacagggcc       60

tctagcaatc ccaatgccac ctctagctct agccaggatc ctgagagcct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcccattctg      180

gaggtgtctt ctctgcccac caccaatagc accactaatt ctgccaccaa gatcactgct      240

aacaccactg atgagcccac cactcagcct accactgagc ccaccaccca gcccactatc      300

cagcccaccc agcccaccac ccagctgcct actgacagcc ctacccagcc cactactggg      360

agcttctgcc ctggccctgt gaccctgtgc tctgacctgg agagccacag cactgaggct      420

gtgctggggg atgccctggt ggacttcagc ctgaagctgt accatgcctt ttctgccatg      480

aagaaggtgg agaccaacat ggcctttagc cctttcagca ttgccagcct gctgactcag      540

gtgctgctgg gggctgggga gaacaccaag accaacctgg agagcatcct gagctacccc      600

aaggacttca cttgtgtgca ccaggccctg aagggcttca ctaccaaggg ggtgacttct      660

gtgagccaga tcttccacag ccctgacctg gccatcaggg atacttttgt gaatgccagc      720

aggaccctgt acagcagcag ccccagggtg ctgagcaaca actctgatgc taacctggag      780

ctgatcaata cttgggtggc caagaacacc aacaacaaga tttctaggct gctggactct      840

ctgccctctg acactaggct ggtgctgctg aatgccatct acctgtctgc caagtggaag      900

accacctttg atcccaagaa gactaggatg gagcccttcc acttcaagaa ctctgtgatc      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc atttcattga ccagaccctg     1020

aaggccaagg tggggcagct gcagctgagc cacaatctga gcctggtgat tctggtgccc     1080

cagaatctga agcacagact ggaggacatg gagcaggctc tgtctccctc tgtgttcaag     1140

gccatcatgg agaagctgga gatgagcaag ttccagccca ctctgctgac tctgcctagg     1200

atcaaggtga ccaccagcca ggacatgctg agcattatgg agaagctgga gttctttgac     1260

ttcagctatg acctgaacct gtgtggcctg actgaggacc ctgatctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gctatttctg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gtttcctgtg ttcatgggga gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  123
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH1

<400>  123
atggcctcca ggctcaccct gctgaccctc ctgctgcttc tgcttgctgg ggatagagcc       60

tcctcaaatc caaatgccac atctagctcc tcccaggatc cagaaagctt gcaagacagg      120

ggagagggca aggtggcaac tactgtgatt tccaagatgc tgtttgtgga gcccatcctg      180

gaggtttcca gcttgcctac aaccaactct actaccaatt cagccaccaa aattactgct      240

aataccactg atgagccaac aacccagcca accacagagc ccaccacaca gcccaccatc      300

caacccaccc aaccaactac ccagctccca actgactctc ctacccagcc taccactggc      360

tccttctgcc ctggacctgt tactctctgc tctgacttgg agagccattc aactgaggca      420

gtcctggggg atgctttggt agatttcagc ctgaagcttt accatgcttt ttcagctatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagta tagcaagtct cctgactcag      540

gtcctgctgg gggcagggga gaatacaaag accaacctgg agagcatcct cagttatccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caacaaaggg ggtgacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctgt acagctccag tcccagagtc ctaagcaaca acagtgatgc aaatttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccaagtg atacaaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtctggtaat cctggtaccc     1080

cagaacctga aacataggct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccataatgg agaagctgga gatgtccaag ttccagccca ctctcctaac actacccagg     1200

atcaaagtga caaccagcca ggatatgctc tcaatcatgg agaaattgga attttttgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgca     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcaagt     1380

gcaatatctg tggccagaac cctgctggtc tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtatatga ccccagggcc     1500

tga                                                                   1503


<210>  124
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH2

<400>  124
atggcttcca ggctcaccct gctgaccctc ctgctgcttc tgctggctgg ggacagggcc       60

tcctcaaatc caaatgctac ctctagctcc tcacaagatc cagaaagcct tcaagacagg      120

ggggagggca aggtggcaac tactgtgatt tccaagatgc tgtttgtgga gcccatcctg      180

gaagtcagca gcttgcctac aaccaactca acaaccaatt ctgccaccaa aattacagct      240

aataccacag atgagcctac aacacaaccc actactgagc caaccactca gcctactatc      300

caacctaccc aaccaactac ccagctccca acagattctc ctactcagcc caccactggc      360

tccttctgcc caggacctgt tactctctgc tctgacttgg aaagccattc aacagaggca      420

gtgctggggg atgctttggt agatttctcc cttaagcttt accatgcctt ttcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagta tagcaagtct cctgactcag      540

gtcctgctgg gggcagggga gaatacaaag accaacctgg agagcatcct cagttatccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caacaaaggg ggtgacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctgt actccagttc ccccagagtc ctaagcaaca acagtgatgc aaatttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccaagtg atacaaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtctggtaat cctggtaccc     1080

cagaacctga aacataggct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccataatgg agaagctgga gatgtccaag ttccagccca ctctcctaac actacccagg     1200

atcaaagtga caaccagcca ggatatgctc tcaatcatgg agaaattgga attttttgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgca     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcaagt     1380

gcaatatctg tggccagaac cctgctggtc tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtatatga ccccagggcc     1500

tga                                                                   1503


<210>  125
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH3

<400>  125
atggcctcca ggctgaccct gctgaccctc ctgctgttgc tgctggctgg ggacagagcc       60

tcctctaatc caaatgctac cagctcctcc tctcaggacc cagagtccct tcaggacagg      120

ggggagggca aggtggccac aactgtcatt tccaagatgc tgtttgtgga gcccatcctg      180

gaggtttcca gcctgcctac taccaactcc actaccaatt cagccaccaa gattacagcc      240

aacaccacag atgagccaac tactcagccc actacagagc ctaccaccca gcctaccatc      300

caacccaccc aacccactac ccagctcccc acagattccc ctacccagcc caccactggc      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agtctcatag cacagaggct      420

gtgctggggg atgccttggt ggacttctcc ctgaagctct accatgcttt ctctgctatg      480

aagaaggtgg agaccaacat ggccttctcc ccattctcca tagcaagtct cctgactcag      540

gtcctgctgg gggcagggga gaacacaaaa acaaacctgg agagcatcct cagttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca ccacaaaggg ggtgacctca      660

gtgtcccaga ttttccacag ccctgacctg gccatcaggg acacctttgt gaatgcctcc      720

aggaccctgt actccagctc accaagggtg ctgagcaaca acagtgatgc aaatctggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccaagtg acacaaggct tgtcctcctc aatgccatct acctgagtgc caagtggaag      900

accacatttg accccaagaa gaccaggatg gagcccttcc acttcaagaa ctcagttatc      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc acttcattga ccagactttg     1020

aaggccaagg tggggcagct ccagctctcc cacaatctga gcctggtcat cctggtaccc     1080

cagaacctga aacacaggct tgaagacatg gaacaggccc tcagcccatc agtgttcaag     1140

gcaataatgg agaagctgga gatgtccaag ttccagccca ctctcctgac ccttcccagg     1200

atcaaagtca caaccagcca ggacatgctc tcaatcatgg agaagttgga gttctttgac     1260

ttcagctatg accttaacct gtgtgggctg acagaggacc ctgaccttca ggtctctgcc     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcagc tgcagctagt     1380

gcaatatctg tggccagaac cctgctggtc tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtg ttcatgggga gggtctatga ccccagggcc     1500

tga                                                                   1503


<210>  126
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH4

<400>  126
atggcctcca ggctgaccct gctgaccctc ctgctgctcc tgctggctgg ggacagggcc       60

agcagcaacc ccaatgccac ctcctcctcc agtcaggacc cagagtctct ccaggacagg      120

ggggagggca aggtggccac cactgtgatc agcaagatgc tgtttgtgga gcccatcctg      180

gaggtcagct ccctgcctac aaccaactca accaccaaca gtgccaccaa gataactgcc      240

aacaccactg atgagcccac aacccagcca accacagagc ctaccacaca gcctacaatc      300

caacccaccc agcccactac ccagctgccc acagactcac ctacacagcc caccactggc      360

tccttctgcc caggaccagt gaccctctgc tctgacctgg agagtcactc cacagaggca      420

gtgctggggg atgccctggt ggacttcagc ctgaagctgt accatgcctt cagtgcaatg      480

aagaaggtgg agaccaacat ggccttctcc ccattctcaa ttgcctccct cctgacccag      540

gtcctgctgg gggcagggga gaacactaag accaacctgg agtccatcct ctcctacccc      600

aaggacttca cctgtgtgca ccaggccctg aaggggttca ccactaaggg ggtgacctca      660

gtgtcccaga ttttccacag cccagacctg gccatcaggg acacctttgt gaatgcctcc      720

aggaccctgt actccagcag ccccagagtc ctgagcaaca actcagatgc aaacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gttggacagt      840

ctgccatcag acacaaggct ggtcctcctg aatgctatct acctcagtgc caagtggaag      900

acaacctttg accccaagaa gaccagaatg gagcccttcc acttcaagaa ctcagtcatc      960

aaggtcccca tgatgaacag caagaagtac cctgtggccc acttcattga ccagaccctg     1020

aaggccaagg tggggcagct gcagctctcc cacaacctgt ccctggtcat cctggtcccc     1080

cagaacctca agcacaggct ggaggacatg gagcaggccc tcagcccctc tgtgttcaag     1140

gccataatgg agaagctgga gatgtccaag ttccagccca ccctcctcac cctacccagg     1200

atcaaggtga ccaccagcca ggacatgctc tccatcatgg agaagttgga gttctttgac     1260

ttctcttatg acctcaacct gtgtgggctg acagaggacc ctgacctgca ggtgtctgca     1320

atgcagcacc agacagtgct ggagctgact gagactgggg tggaggctgc tgctgcctct     1380

gccatctctg tggccagaac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtg ttcatgggga gggtgtatga ccccagggcc     1500

tag                                                                   1503


<210>  127
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH5

<400>  127
atggcctcca ggctgaccct gctgaccctc ctgctgcttc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac ctcttcaagc tcccaggacc cagaaagcct tcaagacagg      120

ggggagggca aggtggctac aactgtgatt tccaagatgc tgtttgtgga acccatcctt      180

gaagtcagca gcttgcctac taccaacagc acaaccaatt cagccaccaa aattacagct      240

aataccacag atgagccaac tactcaaccc accactgagc ccaccacaca gcccactatt      300

cagcccaccc aaccaactac ccaactccca actgattctc ctacccaacc taccactggc      360

tccttctgcc ctggacctgt tactctctgc tctgacttgg agtctcattc aacagaggca      420

gtgctggggg atgctttggt tgatttctcc ctgaagctct accatgcctt ttcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagta tagcaagtct cctgactcag      540

gtcctgctgg gggcagggga gaatacaaag accaacctgg agagcatcct cagttatccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caacaaaggg ggtgacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctgt actccagctc ccccagagtc ctaagcaaca acagtgatgc aaatttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccaagtg atacaaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtctggtaat cctggtaccc     1080

cagaacctga aacataggct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gcaataatgg agaagctgga gatgtccaag ttccagccca ctctcctaac actacccagg     1200

atcaaagtga caaccagcca ggatatgctc tcaatcatgg agaaattgga attttttgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgca     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcaagt     1380

gcaatatctg tggccagaac cctgctggtc tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtatatga ccccagggcc     1500

tga                                                                   1503


<210>  128
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH6

<400>  128
atggcctcca ggctgaccct gctgaccctc ctgctgcttc tgctggctgg ggatagggcc       60

tcctctaatc caaatgctac cagcagtagt tcacaggacc cagagagcct gcaggacagg      120

ggggagggca aggtggctac tactgtgatt tccaagatgc tgtttgtgga gcccatcctg      180

gaggtctcct ccctgcctac caccaactcc actaccaact cagccaccaa aattacagct      240

aataccacag atgagccaac aacacagcca actacagaac ccaccaccca gcctactatc      300

caacccaccc aaccaactac ccagctccct actgattctc ctactcagcc cacaactggc      360

tccttctgcc caggtcctgt taccctctgc tctgacctgg aatctcattc cacagaggca      420

gtcctggggg atgccttggt ggacttctcc ctgaagctct accatgcttt ttctgctatg      480

aagaaggtgg agaccaacat ggccttttcc ccattctcca tagccagtct cctgactcag      540

gtcctgctgg gggcagggga gaacacaaag accaacctgg agagcatcct ctcatatccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca caaccaaggg ggtcacctca      660

gtctcccaga ttttccacag cccagacctg gccatcaggg acacctttgt gaatgcctcc      720

aggaccttat acagcagctc acccagggtg ctaagcaaca acagtgatgc aaacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagactcc      840

ctgcccagtg atacaaggct tgtcctcctc aatgccatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa gaccagaatg gagccctttc acttcaagaa ctcagtcata      960

aaggtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccagactctg     1020

aaagccaagg tggggcagct ccagctctcc cacaacctga gcctggtaat cctggtgccc     1080

cagaacctga agcacaggct tgaggacatg gaacaggctc tcagcccttc tgttttcaag     1140

gcaataatgg agaagctgga gatgtccaag ttccagccca ctctcctaac acttcccagg     1200

atcaaggtga ccaccagcca ggatatgctc agcatcatgg agaaactaga gttctttgac     1260

ttctcttatg accttaacct gtgtggcctg actgaggacc ctgaccttca ggtttctgca     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcatca     1380

gcaatcagtg tggccagaac cctcctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  129
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH7

<400>  129
atggcctcca ggctgaccct gctgaccctc ctgctgcttc tgctggctgg ggatagggcc       60

agctccaacc ccaatgccac ttccagctct tcccaagatc cagaatccct tcaggacagg      120

ggggagggca aggtggcaac tactgtgatt tccaagatgc tgtttgtgga gcccatcctg      180

gaggtttcca gcttgccaac aaccaatagc accaccaact cagccaccaa gatcacagcc      240

aataccacag atgagcctac aacacagcca actactgagc ccaccacaca gcctaccatc      300

caacccaccc aaccaaccac ccagctcccc acagactccc ctacccagcc cacaactggc      360

tccttctgcc caggacctgt taccctctgc tctgacttgg agtcacattc tacagaggca      420

gtgctggggg atgctttggt agatttcagc ctgaagctct accatgcctt ctctgccatg      480

aagaaggtgg agaccaacat ggccttctcc ccattcagta tagccagtct cctgactcag      540

gtcctgctgg gggcagggga gaacacaaag actaacctgg agagcatcct cagttacccc      600

aaggacttca cctgtgtcca ccaggccctg aaggggttca ccaccaaggg ggtgacctca      660

gtctctcaga ttttccacag cccagacctg gccatcaggg acacctttgt gaatgcctct      720

aggaccctct acagcagctc acccagagtc cttagcaaca acagtgatgc caacctggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagactca      840

ctgcctagtg acacaaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

accacatttg accccaagaa gaccaggatg gagccctttc acttcaagaa ctctgtcata      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc atttcataga ccagactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaacctga gtctggtaat cctggtaccc     1080

cagaacctga agcataggct tgaggacatg gagcaggctc tctccccctc tgtcttcaag     1140

gccataatgg agaagctgga gatgtccaag ttccagccca ctctgctaac tctccccagg     1200

atcaaagtga ctaccagcca ggacatgctg tcaatcatgg agaagttgga gttctttgat     1260

ttctcctatg accttaacct gtgtgggctg acagaggacc ctgatctgca ggtttctgcc     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggctgc tgcagcctca     1380

gcaatcagtg tggccagaac cctgctggtg tttgaggtcc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttcccagtc ttcatgggga gggtctatga ccccagggcc     1500

tag                                                                   1503


<210>  130
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH8

<400>  130
atggcctcca ggctgaccct gctgaccctc ctgctgcttc tgctggctgg ggacagagcc       60

tcctcaaatc caaatgccac tagctcctct tcccaagacc cagaatccct tcaagacagg      120

ggggagggca aggttgccac aactgtgatt agcaagatgc tgtttgtgga gcccatcctg      180

gaggtctcca gcctgcctac caccaacagc acaaccaact cagccaccaa gattacagct      240

aataccactg atgagcctac aacccagcca actacagaac ccaccactca gcctaccatc      300

caacccaccc aaccaaccac ccagctcccc acagacagcc ctacacagcc cactactggc      360

tccttctgcc caggacctgt gaccctctgc tctgacttgg agtctcactc cacagaggca      420

gtgctggggg atgctttggt agacttctcc ctgaagctct accatgcctt ttctgctatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagta tagccagtct cctgactcag      540

gtcctgctgg gggcagggga gaacactaag accaacctgg agagcatcct cagttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caaccaaggg ggtcacctca      660

gtctctcaga ttttccacag cccagacctg gccatcaggg acacctttgt gaatgcctca      720

aggacccttt acagcagcag tcccagggtc ctaagcaaca acagtgatgc aaaccttgag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccctctg atacaaggct tgtcctcctc aatgctatct acctcagtgc caagtggaag      900

actacatttg accccaagaa gaccaggatg gaacccttcc acttcaagaa ctcagttata      960

aaggtgccca tgatgaatag caagaagtac cctgtggccc acttcattga ccaaactttg     1020

aaggccaagg tggggcagct gcagctctcc cacaatctga gtctggtcat cctggtaccc     1080

cagaacctca aacacaggct tgaagacatg gagcaggctc tctccccttc tgttttcaag     1140

gcaataatgg agaagctgga gatgtccaag ttccagccca ccctcctaac actacccagg     1200

atcaaggtga caaccagcca ggatatgctc tcaatcatgg agaagttgga attctttgac     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgaccttca ggtttctgcc     1320

atgcagcacc agactgtgct ggaactgaca gagactgggg tggaagctgc tgcagcatca     1380

gcaatatctg tggccagaac cctgctggtg tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtatatga ccccagggcc     1500

tga                                                                   1503


<210>  131
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH9

<400>  131
atggcctcca ggctgaccct gctgaccctc ctgctgctcc tgctggctgg ggatagagcc       60

tctagcaatc caaatgctac cagctcctcc tcccaggatc ctgaatccct tcaagacagg      120

ggggagggca aggtggcaac tactgtgatt tccaagatgc tgtttgtgga gcccatcctg      180

gaggttagca gccttcctac taccaactca acaaccaatt cagccaccaa aattacagct      240

aataccacag atgagccaac aactcaaccc accactgagc ccaccactca gccaaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc taccactggc      360

tccttctgcc caggacctgt tactctctgc tctgacttgg aaagccattc tactgaggct      420

gtcctggggg atgctttggt agacttctcc ctgaagctct accatgcatt ttcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagta tagcaagtct cctgactcag      540

gtcctgctgg gggcagggga gaatacaaag accaacctgg agagcatcct cagttatccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caacaaaggg ggtgacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctgt actcaagctc ccccagagtc ctaagcaaca acagtgatgc aaatttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccaagtg atacaaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtctggtaat cctggtaccc     1080

cagaacctga aacataggct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccataatgg agaagctgga gatgtccaag ttccagccca ctctcctaac actacccagg     1200

atcaaagtga caaccagcca ggatatgctc tcaatcatgg agaaattgga attttttgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgca     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcaagt     1380

gcaatatctg tggccagaac cctgctggtc tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtatatga ccccagggcc     1500

tga                                                                   1503


<210>  132
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH10

<400>  132
atggcctcca ggctgaccct gctgaccctc ctgcttcttc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctctagc tctcaggatc cagaatccct tcaagacagg      120

ggggagggca aggtggcaac tactgtgatt tccaagatgc tgtttgtgga gcccatcctg      180

gaagtgtcca gcttgcctac aaccaactcc acaaccaatt cagccaccaa aattacagct      240

aataccacag atgagccaac aactcaaccc accactgagc ccaccactca gcccactatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc taccactggc      360

tccttctgcc ctggacctgt tactctctgc tctgacttgg aaagccattc aactgaggca      420

gtcctggggg atgctttggt agacttctcc ctgaagcttt accatgcatt ttcagctatg      480

aagaaagtgg agaccaacat ggccttttcc ccattcagta tagcaagtct cctgactcag      540

gtcctgctgg gggcagggga gaatacaaag accaacctgg agagcatcct cagttatccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caacaaaggg ggtgacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctct acagcagctc cccaagagtc ctaagcaaca acagtgatgc aaatttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccaagtg atacaaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtctggtaat cctggtaccc     1080

cagaacctga aacataggct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccataatgg agaagctgga gatgtccaag ttccagccca ctctcctaac actacccagg     1200

atcaaagtga caaccagcca ggatatgctc tcaatcatgg agaaattgga attttttgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgca     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcaagt     1380

gcaatatctg tggccagaac cctgctggtc tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtatatga ccccagggcc     1500

tga                                                                   1503


<210>  133
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH11

<400>  133
atggcctcca ggctgaccct gctgaccctc ctgcttctcc tgctggctgg ggacagggcc       60

tctagcaatc caaatgctac cagctcctcc tcccaggatc cagaaagctt gcaagacagg      120

ggggaaggca aggtggcaac tactgtgatt tccaagatgc tgtttgttga gcccatcctg      180

gaggtctcta gcttgcctac taccaactca actaccaatt cagccaccaa aattacagct      240

aataccacag atgagccaac aacccaaccc accactgagc ccaccactca gcccaccatc      300

caacctaccc aaccaactac ccagctccca actgattctc ctacccagcc taccactggc      360

tccttctgcc caggacctgt tactctctgc tctgaccttg aatcccattc aacagaggca      420

gtgctggggg atgctttggt agatttctcc ctgaagcttt accatgcctt ttcagctatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagta tagcaagtct cctgactcag      540

gtcctgctgg gggcagggga gaatacaaag accaacctgg agagcatcct cagttatccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caacaaaggg ggtgacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctgt acagcagctc ccccagagtc ctaagcaaca acagtgatgc aaatttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccaagtg atacaaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtctggtaat cctggtaccc     1080

cagaacctga aacataggct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gcaataatgg agaagctgga gatgtccaag ttccagccca ctctcctaac actacccagg     1200

atcaaagtga caaccagcca ggatatgctc tcaatcatgg agaaattgga attttttgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgca     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcaagt     1380

gcaatatctg tggccagaac cctgctggtc tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtatatga ccccagggcc     1500

tga                                                                   1503


<210>  134
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH13

<400>  134
atggcctcca ggctgaccct gctcaccctc ctgctgctcc tgctggctgg ggacagggcc       60

tccagcaacc ccaatgcaac cagcagttcc tctcaggatc cagagtccct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc tccaagatgc tgtttgtgga gcccatcctg      180

gaggtatcca gcctccctac caccaacagc accaccaact cagccaccaa aatcactgct      240

aacaccactg atgagcccac aacccagcca actactgagc caaccactca gcctaccatc      300

caacccaccc agcctactac ccagctcccc actgactctc ctacccagcc caccactggc      360

agcttctgcc caggacctgt gaccctctgc tctgacttgg agtcccattc cacagaggca      420

gtgctggggg atgccctggt agacttctcc ctgaagctct accatgcatt ctctgccatg      480

aagaaggtgg agaccaacat ggccttctcc cccttcagca ttgccagcct cctgacccag      540

gtcctgctgg gggcagggga gaacacaaag acaaacctgg agtccatcct cagctacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caaccaaggg ggtgaccagt      660

gtctcacaga ttttccacag cccagacctg gccatcaggg acacctttgt gaatgccagt      720

aggaccctgt acagctccag tcccagagtc ctcagcaaca actctgatgc caacctggag      780

ctgatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagactca      840

ctgccctctg acacaaggct ggtcctcctc aatgcaatct acctgagtgc caagtggaag      900

accacctttg accccaagaa gaccaggatg gagcccttcc acttcaagaa cagtgtcatt      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc acttcattga ccagaccttg     1020

aaggccaagg tggggcagct gcagctctcc cacaacctgt cactggtcat cctggttccc     1080

cagaacctga agcacaggct tgaggacatg gagcaggccc tcagcccttc tgtattcaag     1140

gccataatgg agaagctgga gatgagcaag ttccagccca ctctgctgac cctacccagg     1200

atcaaggtga ccaccagcca ggacatgctc tcaatcatgg agaagttgga gttctttgac     1260

ttcagctatg acctgaacct gtgtgggctg acagaggacc ctgacctgca ggtgtcagcc     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcaagt     1380

gctatttcag tggccaggac cctgctggtc tttgaggtcc agcagccctt cctgtttgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatgggga gggtctatga ccccagggcc     1500

tga                                                                   1503


<210>  135
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH14

<400>  135
atggcctcca ggctgaccct gctgaccctt ctgctgttgc tgctggcagg ggacagggcc       60

tcctcaaacc ccaatgccac cagctcttcc agtcaggacc cagagagcct ccaggacagg      120

ggggagggca aggtggccac cactgtgatc tccaagatgc tgtttgtgga gcccatcctg      180

gaggtgtcca gcttgcccac aaccaacagc acaaccaatt cagccaccaa gatcactgct      240

aacaccacag atgagcctac aacccagcca accacagagc ccaccaccca gcctacaatc      300

caacccaccc aacccactac ccagctccca acagactccc ctacccagcc cacaactggc      360

tccttctgcc caggaccagt cactctctgc tctgacttgg agtcacattc aacagaggca      420

gtgctggggg atgctttggt agacttctcc ctgaagctct accatgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttctcc ccattctcca ttgccagtct cctgactcag      540

gtcctgctgg gggctgggga gaacacaaag acaaacctgg agagcatcct cagctacccc      600

aaggacttca cctgtgtcca ccaggccctg aaggggttca ctaccaaggg ggtgaccagt      660

gtctctcaga ttttccacag ccctgacctg gccataaggg acacctttgt gaatgccagt      720

aggaccctgt atagcagctc ccccagagtg ctgagcaaca acagtgatgc caacctggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctggactcc      840

ctgccctctg acaccaggct ggtcctgctc aatgctatct acctgagtgc caagtggaag      900

accacctttg accccaagaa aaccagaatg gagcccttcc acttcaaaaa ctctgtcatc      960

aaggtgccca tgatgaacag caagaagtac ccagtggccc acttcataga ccaaaccctg     1020

aaggccaagg tggggcagct gcagctctcc cacaacctgt ctctggtcat cctggtgccc     1080

cagaacctga agcacaggct tgaggacatg gagcaggccc tcagcccttc tgtcttcaag     1140

gccattatgg agaagctgga gatgtccaag ttccagccca ccctcctaac actccccagg     1200

atcaaagtga caaccagcca ggacatgctc agcatcatgg agaagttgga gttttttgac     1260

ttctcctatg acctaaacct gtgtggcctg acagaggacc ctgaccttca ggtttctgcc     1320

atgcagcacc agactgtgct ggagctgaca gagactgggg tggaagctgc tgcagccagt     1380

gctatctctg tggccagaac cctcctggtc tttgaggtgc agcagccctt cctgtttgtc     1440

ctgtgggacc agcagcacaa gttcccagtc ttcatgggga gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  136
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH15

<400>  136
atggcctcca ggctaaccct gctcaccctc ctgcttcttc tgctggctgg ggacagggcc       60

tcctcaaatc caaatgctac cagctcttct tcccaggatc cagaaagctt gcaagacagg      120

ggggagggca aggtggcaac aactgtcatt tccaagatgc tgtttgtgga gcccatcctg      180

gaggtttcca gcttgcctac taccaactca actaccaatt cagccaccaa aattactgct      240

aataccactg atgagccaac aacccagcca accactgagc ccaccactca gcccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc taccactggc      360

tccttctgcc ctggacctgt tactctctgc tctgacttgg aaagccattc aacagaggct      420

gtgctggggg atgctttggt agatttctcc ctgaagcttt accatgcatt ttcagctatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagta tagcaagtct cctgactcag      540

gtcctgctgg gggcagggga gaatacaaag accaacctgg agagcatcct cagttatccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caacaaaggg ggtgacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctgt atagctccag ccccagagtc ctaagcaaca acagtgatgc aaatttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccaagtg atacaaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtctggtaat cctggtaccc     1080

cagaacctga aacataggct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccataatgg agaagctgga gatgtccaag ttccagccca ctctcctaac actacccagg     1200

atcaaagtga caaccagcca ggatatgctc tcaatcatgg agaaattgga attttttgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgca     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcaagt     1380

gcaatatctg tggccagaac cctgctggtc tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtatatga ccccagggcc     1500

tga                                                                   1503


<210>  137
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH18

<400>  137
atggcctcca ggctgaccct gctgaccctc ctgctgcttc tgctggctgg ggacagagcc       60

tcctcaaatc caaatgccac ttctagctcc tcacaggatc cagaaagctt gcaagacagg      120

ggggagggca aggtggctac aactgtcatt tccaaaatgc tgtttgtgga gcccatcctg      180

gaggtttcca gcttgcctac taccaactca acaaccaatt cagccaccaa aattacagct      240

aataccactg atgagccaac cactcaacct accacagagc ccaccactca gcccaccatt      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc taccactgga      360

tccttctgcc caggacctgt tactctctgc tctgacttgg aaagccattc aactgaggca      420

gtgctggggg atgctttggt agatttctcc ctgaagctct accatgcctt ttctgctatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagta tagcaagtct cctgactcag      540

gtcctgctgg gggcagggga gaatacaaag accaacctgg agagcatcct cagttatccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca caacaaaggg ggtgacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctat actccagcag ccccagggtc ctaagcaaca acagtgatgc aaatttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccaagtg atacaaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtctggtaat cctggtaccc     1080

cagaacctga aacataggct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gcaataatgg agaagctgga gatgtccaag ttccagccca ctctcctaac actacccagg     1200

atcaaagtga caaccagcca ggatatgctc tcaatcatgg agaaattgga attttttgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgca     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaagctgc tgcagcaagt     1380

gcaatatctg tggccagaac cctgctggtc tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtatatga ccccagggcc     1500

tga                                                                   1503


<210>  138
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH19

<400>  138
atggcctcca ggctgaccct gctgaccctc ctcctgttgc tgctggctgg ggacagggca       60

tccagcaacc caaatgccac cagctcttct agtcaggacc cagagtctct ccaggacagg      120

ggggagggca aggtggccac aactgtcatc tccaagatgc tgtttgtgga gcccatcctg      180

gaggtgtcca gcctgcccac caccaactcc acaaccaatt ctgccaccaa gatcactgcc      240

aataccactg atgagcctac aacacagcca accacagagc ccaccacaca gcctaccatc      300

caacccaccc aacccacaac ccagctcccc acagacagcc ccacccagcc cacaactggc      360

tccttctgcc caggacctgt gaccctctgc tctgacttgg agagccactc aactgaggca      420

gtgctggggg atgccttggt ggacttctcc ctgaagctct accatgcctt ctcagccatg      480

aagaaggtgg agaccaacat ggccttcagc cccttctcca tagcctccct cctgactcag      540

gtcctcctgg gggcagggga gaacacaaag acaaacctgg agagcatcct cagttacccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccaccaaggg ggtgaccagt      660

gtcagccaga ttttccacag cccagacctg gccatcaggg acacctttgt caatgcctcc      720

aggaccctgt acagctccag ccccagagtc ctgagcaaca acagtgatgc caacctggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gttggacagc      840

ctcccaagtg ataccaggct agtgctcctc aatgccatct acctgagtgc caagtggaag      900

accacctttg accccaagaa gaccaggatg gaacccttcc acttcaagaa cagtgtcatt      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc acttcattga ccagaccttg     1020

aaggccaagg tgggccagct gcagctctcc cacaacctgt ccctggtcat cctggtgccc     1080

cagaacctga agcacaggct ggaggacatg gaacaggctc tctccccctc tgtcttcaag     1140

gccataatgg agaagctgga gatgtccaag ttccagccca ccctcctaac actccccagg     1200

atcaaggtga caaccagcca ggacatgctc agcatcatgg agaagttgga gttctttgac     1260

ttctcttatg acctgaacct gtgtgggctg acagaggacc ctgacctcca ggtgtctgcc     1320

atgcagcacc agacagtgct ggaactgact gagactgggg tggaggctgc agcagcatca     1380

gccatatctg tggccagaac cctgctggtc tttgaggtcc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtc ttcatgggga gggtctatga ccccagggcc     1500

tga                                                                   1503


<210>  139
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coH20

<400>  139
atggcctcca ggctcaccct gctgaccctc ctcctcctac tgctggctgg ggacagggcc       60

tccagcaacc ccaatgccac ctcctctagt tctcaggacc cagagtcctt gcaggacagg      120

ggggagggca aggtggctac cactgtgatc agcaagatgc tctttgtgga gcccatcctg      180

gaggtctcca gcctccccac taccaacagt accaccaact cagccaccaa gatcacagct      240

aacaccacag atgagccaac aacccagcca actacagagc caaccaccca gcctaccatc      300

caacccaccc aacccactac ccagctcccc acagactccc ctacacagcc cactactggc      360

tccttctgcc ctggccctgt caccctctgc tctgaccttg agagtcacag cacagaggca      420

gtcctggggg atgcccttgt ggacttctcc ctcaagctgt accatgcctt ctcagccatg      480

aagaaggtgg agaccaacat ggccttctcc cccttcagta ttgcaagcct cctgacccag      540

gtcctgctgg gggcagggga gaacactaag accaacctgg agagcatcct gtcctacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca ccaccaaggg ggtgacctca      660

gtgtcccaga tattccacag cccagacctg gccatcaggg acacctttgt gaatgcctcc      720

aggaccctgt acagctcctc ccccagggtc ctaagcaaca actcagatgc caacttggag      780

ctgatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctggactcc      840

ctgccctcag acaccaggct tgtcctgctc aatgccatct acctgagtgc caagtggaag      900

actacctttg accccaagaa gaccaggatg gagcccttcc acttcaagaa ctcagtcatc      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc acttcattga ccaaaccctt     1020

aaggccaagg tggggcagct ccagctcagc cacaacctgt ccctggtcat cctggttccc     1080

cagaacctga agcacaggct ggaggacatg gagcaggccc tcagcccctc tgtcttcaag     1140

gccataatgg agaagctgga gatgtccaag ttccagccca ccctcttgac cttgcccagg     1200

atcaaggtca ccaccagcca ggacatgctg tccatcatgg agaaactgga gttctttgac     1260

ttcagctatg acctcaacct ctgtgggctg acagaggacc ctgacctgca ggtgtctgcc     1320

atgcagcacc agacagtgct ggaactgaca gagacagggg tggaagctgc tgcagcttct     1380

gccatctctg tggccagaac cctgctggtc tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttcccagtc ttcatgggga gggtgtatga ccccagggcc     1500

tag                                                                   1503


<210>  140
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coBC1

<400>  140
atggcctcca ggctgaccct gctgaccctc ctgctgctcc tgctggctgg ggacagggcc       60

agcagcaacc ccaatgccac cagctccagc agccaggacc cagagtctct gcaggacagg      120

ggggagggca aggtggccac cacagtgatc agcaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcttgcctac caccaacagc accaccaact ctgccaccaa gatcacagcc      240

aacaccacag atgagcccac aacccagcct accacagagc caaccacaca gcctacaatc      300

caacccaccc agccaactac ccagctgccc acagacagcc ctacacagcc caccacaggc      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacttgg agagccactc cacagaggct      420

gtgctggggg atgccctggt agacttcagc ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg agaccaacat ggccttcagc cccttctcta ttgccagcct cctgacacag      540

gtcctgctgg gggctgggga gaataccaag acaaacctgg agagcatcct gagctatccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca caacaaaggg ggtgacctct      660

gtgtctcaga ttttccacag ccctgacctg gccattaggg acacctttgt gaatgcctcc      720

aggaccctgt actcaagcag ccccagagtg cttagcaaca actctgatgc taacttggag      780

ctgatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gttggacagc      840

ctgccttctg acaccaggct ggtgctcctg aatgccatct acctgtctgc caagtggaag      900

acaacatttg accccaagaa gaccagaatg gagcccttcc acttcaagaa ctctgtgatt      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc acttcattga ccagacactc     1020

aaggccaagg tgggccagct gcagctcagc cacaatctgt ctctggttat cctggtgccc     1080

cagaacctga agcacaggct tgaggacatg gagcaggccc tcagcccctc tgttttcaag     1140

gccattatgg agaagctgga gatgagcaag ttccagccca ctctcctgac ccttcccagg     1200

atcaaggtga ccaccagcca ggatatgctg tctatcatgg agaagttgga gttctttgac     1260

ttcagctatg acctgaacct gtgtggcctg acagaggacc ctgatcttca ggtttctgct     1320

atgcagcacc agacagtgct ggaactgaca gagacagggg tggaggctgc tgctgcttct     1380

gctatctctg tggccagaac cctgctggtg tttgaagtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtg ttcatgggca gggtttatga ccccagggcc     1500

tga                                                                   1503


<210>  141
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coBC2

<400>  141
atggcctcca ggctgaccct gctgaccctc ctgctgctcc tgctggctgg ggacagagcc       60

agcagcaacc ccaatgccac cagctccagc tctcaggacc cagagagcct gcaggacagg      120

ggggagggca aggtggccac cacagtgatc agcaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctccccac caccaacagc accaccaatt ctgccaccaa gatcacagcc      240

aacaccacag atgagcccac aacccagcct accacagagc caaccacaca gcccaccatc      300

caacccaccc aacctactac ccagctgccc acagacagcc ctacccagcc taccacaggc      360

agcttctgcc ctggccctgt gaccctgtgc tctgacttgg agagccactc cacagaggct      420

gtgctggggg atgccctggt ggatttcagc ctgaagctgt accatgcctt ctctgccatg      480

aagaaggtgg agaccaacat ggccttcagc cccttcagca ttgccagcct cctgacccag      540

gtcctgctgg gggctgggga gaacacaaag accaacctgg agagcatcct gagctacccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccaccaaggg ggtgacctct      660

gtgagccaga ttttccacag ccctgacctg gccatcaggg acacctttgt gaatgcctcc      720

aggaccctgt acagctctag ccccagggtg ctgagcaaca actctgatgc caacttggag      780

ctgatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctggacagc      840

ctgccctctg acaccaggct ggtgctcctg aatgccatct acctgtctgc caagtggaag      900

accacctttg accccaagaa gaccagaatg gagcccttcc acttcaagaa ctctgtgata      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc acttcattga ccagaccctg     1020

aaagccaagg tgggccagct gcagctcagc cacaacctga gcctggtcat cctggtgccc     1080

cagaacctga agcacaggct ggaggacatg gaacaggccc tcagcccctc tgtgttcaag     1140

gccattatgg agaagctgga gatgagcaag ttccagccca ctctgctgac actgcccagg     1200

atcaaggtga ccaccagcca ggacatgctg agcatcatgg agaagttgga gttctttgac     1260

ttcagctatg acctgaacct gtgtggcctg acagaggacc ctgacctcca ggtgtctgcc     1320

atgcagcacc agacagtgct ggaactgaca gagacagggg tggaagctgc tgctgcctct     1380

gccatctctg tggccagaac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtg ttcatgggca gggtgtatga ccccagggcc     1500

tga                                                                   1503


<210>  142
<211>  1543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI21(-RIDD)

<400>  142
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggacagggcc       60

agctctaacc ccaatgctac ttctagctcc tctcaggacc ctgagagcct tcaggacagg      120

ggggagggca aggtggccac cactgtgatc tctaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac caccaacagc accaccaact ctgccactaa gatcactgcc      240

aacaccactg atgagcccac cacccagccc actactgagc ccaccaccca gcctactatc      300

cagcccaccc agcccactac ccagctgccc actgacagcc ctacccagcc caccactggc      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg agagccattc tactgaggct      420

gtgctggggg atgccctggt ggacttctct ctgaagctgt accatgcttt ctctgccatg      480

aagaaggtgg agactaacat ggcttttagc cccttcagca ttgctagcct gctgacccag      540

gtgctgctgg gggctgggga gaacactaag accaacctgg aatctatcct gagctacccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccaccaaggg ggtgacctct      660

gtgagccaga tcttccacag ccctgacctg gccatcaggg atacttttgt gaatgccagc      720

agaaccctgt actcttctag ccccagggtg ctgagcaata attctgatgc taacctggag      780

ctgatcaata cctgggtggc taagaatacc aacaacaaga ttagcaggct gctggactct      840

ctgccttctg ataccaggct ggtgctgctg aatgccattt acctgtctgc caagtggaag      900

accacttttg accctaagaa gactaggatg gagcctttcc acttcaagaa ctctgtcatt      960

aaggtgccca tgatgaacag caagaagtat cctgtggccc actttattga ccagactctg     1020

aaggccaagg tgggccagct tcagctgagc cataacctga gcctggtgat cctggtgccc     1080

cagaacctga agcataggct ggaggacatg gagcaggctc tgagcccctc tgtgttcaag     1140

gctattatgg agaagctgga gatgagcaag ttccagccca ctctgctgac cctgcccaga     1200

atcaaggtga ccacctctca ggacatgctg agcatcatgg aaaagctgga gttctttgac     1260

ttttcttatg acctgaatct gtgtggcctg actgaggatc ctgatcttca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcttct     1380

gccatctctg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gtttcctgtg ttcatgggca gggtgtatga ccccagagcc     1500

tgaagatcta gagctgaatt ccttcagcca gggggatcag cct                       1543


<210>  143
<211>  1281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_delta76

<400>  143
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc ccaccatcca acccacccaa ccaactaccc agctcccaac agattctcct      120

acccagccca ctactgggtc cttctgccca ggacctgtta ctctctgctc tgacttggag      180

agtcattcaa cagaggccgt gttgggggat gctttggtag atttctccct gaagctctac      240

cacgccttct cagcaatgaa gaaggtggag accaacatgg ccttttcccc attcagcatc      300

gccagcctcc ttacccaggt cctgctcggg gctggggaga acaccaaaac aaacctggag      360

agcatcctct cttaccccaa ggacttcacc tgtgtccacc aggccctgaa gggcttcacg      420

accaaaggtg tcacctcagt ctctcagatt ttccacagcc cagacctggc cataagggac      480

acctttgtga atgcctctcg gaccctgtac agcagcagcc ccagagtcct aagcaacaac      540

agtgacgcca acttggagct catcaacacc tgggtggcca agaacaccaa caacaagatc      600

agccggctgc tagacagtct gccctccgat acccgccttg tcctcctcaa tgctatctac      660

ctgagtgcca agtggaagac aacatttgat cccaagaaaa ccagaatgga accctttcac      720

ttcaaaaact cagttataaa agtgcccatg atgaatagca agaagtaccc tgtggcccat      780

ttcattgacc aaactttgaa agccaaggtg gggcagctgc agctctccca caatctgagt      840

ttggtgatcc tggtacccca gaacctgaaa catcgtcttg aagacatgga acaggctctc      900

agcccttctg ttttcaaggc catcatggag aaactggaga tgtccaagtt ccagcccact      960

ctcctaacac taccccgcat caaagtgacg accagccagg atatgctctc aatcatggag     1020

aaattggaat tcttcgattt ttcttatgac cttaacctgt gtgggctgac agaggaccct     1080

gatcttcagg tttctgcgat gcagcaccag acagtgctgg aactgacaga gactggggtg     1140

gaggcggctg cagcctccgc catctctgtg gcccgcaccc tgctggtctt tgaagtgcag     1200

cagcccttcc tcttcgtgct ctgggaccag cagcacaagt tccctgtctt catggggcga     1260

gtatatgacc ccagggcctg a                                               1281


<210>  144
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_delta98

<400>  144
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatg ggtccttctg cccaggacct gttactctct gctctgactt ggagagtcat      120

tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct ctaccacgcc      180

ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag catcgccagc      240

ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct ggagagcatc      300

ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt cacgaccaaa      360

ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag ggacaccttt      420

gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa caacagtgac      480

gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa gatcagccgg      540

ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat ctacctgagt      600

gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt tcacttcaaa      660

aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc ccatttcatt      720

gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct gagtttggtg      780

atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc tctcagccct      840

tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc cactctccta      900

acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat ggagaaattg      960

gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga ccctgatctt     1020

caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg ggtggaggcg     1080

gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt gcagcagccc     1140

ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg gcgagtatat     1200

gaccccaggg cctga                                                      1215


<210>  145
<211>  3608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1co21(Intron 1-2, 2-3)

<400>  145
gtaggtttgg tgctgggcag gggtggggag tagggtggaa agcatggagt gaagaggtct       60

agggaggggg tctcctcacc cccgccttcc tgcccgcctt gatctcgggg gtctctatag      120

gcttgcttcc acctgggact tctgcctcct cctaccccag cccctcccgc ctcaggcctg      180

ttgtgctcag ccccccagga cctcccctcc cccacgcctc tggcctcatt gtttggttaa      240

agcaggaccc cctccccctc ccaccacctc ccctccgact gaacagatgg acagagaccc      300

gggcccacgg ggagaggaag ggccagccgg tgccgggaaa gggaagcggt ttggggaaaa      360

caaaacagag ggaggagcca gggagaaggt ggccccagga gggaggagga gggaattcgc      420

taagagggac tggggcctga gacggaatgg gggcgggccc cgggcggggt gggggcccct      480

gggctcccag ggtgggagct ggctccgagg ctggctggct ccgcaggtcc gctgacgtcg      540

ccgcccagat ggcctctagg ctgactctgc tgactctgct gctcctgctg ctggctgggg      600

tatgtggtcc cttgtgggat gggggacggg ggtggagacg ggaggcggga tggtgcgggg      660

tgcgggcggt ggctgaggat taacccttca ggctccgggg aatgaggaga gctcctcttg      720

ggatcattga gtgtgatcct tgcacacgca ctcgtagatg gtggaaagag ctcaggactc      780

agacagatgc aagttctaat cttggcgggc catgtaggag ctgcgcagcg tggtcctgag      840

gacgtcactt ttctcagcct actcctcctg atttataaaa tgttgaataa acagatccca      900

ccctgtccac caagcaggct tggcaggagg atcacatagg gcaaggagat gggaagcatt      960

ttgtgatatc aaagcaagag tttgttgtag aaaagagctg tggggaggag aggtttggct     1020

gctgtgacac agacggtggt cccaggctag ggcctgtgaa gacagggaag aatggtagca     1080

aacatacgtg ggtctgggtg ggggtcaata gcagtgagag gtcccagtgg tctgggaggt     1140

catggactag aaataaggct aagaagtgca ggatcccagg agaaaggtag gtaggggtgt     1200

gtgtatgtgc gtgtgtgtgt gtgtgcacgc gcaagttggt atcacatact cagcagatga     1260

tgtagttatg agcagggagt ttggaatcag agaccttgtt ttgaccccta gctgtttctc     1320

ccatttctgt gagaccctgg actagttaat atgtgtcggt atgagtttct ctacctgtga     1380

aatggagcta atgcgtggtt tctcagtgga ggatctgttg acattggggc tggataattc     1440

attgctgagg ggctaccctg cgcattttag gatgttttgc agtatatctc tagcctctac     1500

gcactagatt ccggtagcat cttccctgct gtctccctgt gacaaccaaa aatgtctctg     1560

gacattgcca aatatcccct gggagtcaaa attgtttcag agccgctggc ctatactact     1620

tctctctccc tcccttcctg cctcccttct ttcctccttc cctttcttcg ttcccttcct     1680

aatgtgtact gtttttccac acccactaat gggttgcaac ccacagttta aaaatttact     1740

gttctaaatc aaggagcaca agttcaaatg tctgtactag ccaagcaagt gagtcaaaca     1800

ggtagatatt tacaggaaat tgcaagaaca tagataaatg acaacactca gcttcactgt     1860

ttggaaaaca acttcctaca gggcagtaat tggtcagaga ttacagagtc cctgactatc     1920

cctcatcttc tgcagagcac attcctgtgc acccccaccc tcaccctgta ttgccccttc     1980

tctgaggaat tagtggtggt ggttctaaga cagattgctc atctgccgca ctgtcagaaa     2040

ttactctctt gtacaggaca ttttccacat ccacaccttc tcttcctgct ttgagtattt     2100

tagaggactg tgcctcgtag taagaaaaaa atgaaactca gtttcttgaa ccacaggaca     2160

gggccagctc taaccccaat gctacttcta gctcctctca ggaccctgag agcctgcagg     2220

acagggggga gggcaaggtg gccaccactg tgatctctaa gatgctgttt gtggagccca     2280

tcctggaggt gagcagcctg cccaccacca acagcaccac caactctgcc actaagatca     2340

ctgccaacac cactgatgag cccaccaccc agcccactac tgagcccacc acccagccta     2400

ctatccagcc cacccagccc actacccagc tgcccactga cagccctacc cagcccacca     2460

ctggcagctt ctgccctggg cctgtgaccc tgtgctctga cctggagagc cattctactg     2520

aggctgtgct gggggatgcc ctggtggact tctctctgaa gctgtaccat gctttctctg     2580

ccatgaagaa ggtggagact aacatggctt ttagcccctt cagcattgct agcctgctga     2640

cccaggtgct gctgggggct ggggagaaca ctaagaccaa cctggaatct atcctgagct     2700

accccaagga cttcacctgt gtgcaccagg ccctgaaggg cttcaccacc aagggggtga     2760

cctctgtgag ccagatcttc cacagccctg acctggccat cagggatact tttgtgaatg     2820

ccagcagaac cctgtactct tctagcccca gggtgctgag caataattct gatgctaacc     2880

tggagctgat caatacctgg gtggctaaga ataccaacaa caagattagc aggctgctgg     2940

actctctgcc ttctgatacc aggctggtgc tgctgaatgc catttacctg tctgccaagt     3000

ggaagaccac ttttgaccct aagaagacta ggatggagcc tttccacttc aagaactctg     3060

tcattaaggt gcccatgatg aacagcaaga agtatcctgt ggcccacttt attgaccaga     3120

ctctgaaggc caaggtgggc cagctgcagc tgagccataa cctgagcctg gtgatcctgg     3180

tgccccagaa cctgaagcat aggctggagg acatggagca ggctctgagc ccctctgtgt     3240

tcaaggctat tatggagaag ctggagatga gcaagttcca gcccactctg ctgaccctgc     3300

ccagaatcaa ggtgaccacc tctcaggaca tgctgagcat catggaaaag ctggagttct     3360

ttgacttttc ttatgacctg aatctgtgtg gcctgactga ggatcctgat ctgcaggtgt     3420

ctgccatgca gcaccagact gtgctggagc tgactgagac tggggtggag gctgctgctg     3480

cttctgccat ctctgtggcc aggaccctgc tggtgtttga ggtgcagcag cccttcctgt     3540

ttgtgctgtg ggaccagcag cacaagtttc ctgtgttcat gggcagggtg tatgacccca     3600

gagcctga                                                              3608


<210>  146
<211>  3060
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1co21(Intron 2-3)

<400>  146
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggtatgtggt       60

cccttgtggg atgggggacg ggggtggaga cgggaggcgg gatggtgcgg ggtgcgggcg      120

gtggctgagg attaaccctt caggctccgg ggaatgagga gagctcctct tgggatcatt      180

gagtgtgatc cttgcacacg cactcgtaga tggtggaaag agctcaggac tcagacagat      240

gcaagttcta atcttggcgg gccatgtagg agctgcgcag cgtggtcctg aggacgtcac      300

ttttctcagc ctactcctcc tgatttataa aatgttgaat aaacagatcc caccctgtcc      360

accaagcagg cttggcagga ggatcacata gggcaaggag atgggaagca ttttgtgata      420

tcaaagcaag agtttgttgt agaaaagagc tgtggggagg agaggtttgg ctgctgtgac      480

acagacggtg gtcccaggct agggcctgtg aagacaggga agaatggtag caaacatacg      540

tgggtctggg tgggggtcaa tagcagtgag aggtcccagt ggtctgggag gtcatggact      600

agaaataagg ctaagaagtg caggatccca ggagaaaggt aggtaggggt gtgtgtatgt      660

gcgtgtgtgt gtgtgtgcac gcgcaagttg gtatcacata ctcagcagat gatgtagtta      720

tgagcaggga gtttggaatc agagaccttg ttttgacccc tagctgtttc tcccatttct      780

gtgagaccct ggactagtta atatgtgtcg gtatgagttt ctctacctgt gaaatggagc      840

taatgcgtgg tttctcagtg gaggatctgt tgacattggg gctggataat tcattgctga      900

ggggctaccc tgcgcatttt aggatgtttt gcagtatatc tctagcctct acgcactaga      960

ttccggtagc atcttccctg ctgtctccct gtgacaacca aaaatgtctc tggacattgc     1020

caaatatccc ctgggagtca aaattgtttc agagccgctg gcctatacta cttctctctc     1080

cctcccttcc tgcctccctt ctttcctcct tccctttctt cgttcccttc ctaatgtgta     1140

ctgtttttcc acacccacta atgggttgca acccacagtt taaaaattta ctgttctaaa     1200

tcaaggagca caagttcaaa tgtctgtact agccaagcaa gtgagtcaaa caggtagata     1260

tttacaggaa attgcaagaa catagataaa tgacaacact cagcttcact gtttggaaaa     1320

caacttccta cagggcagta attggtcaga gattacagag tccctgacta tccctcatct     1380

tctgcagagc acattcctgt gcacccccac cctcaccctg tattgcccct tctctgagga     1440

attagtggtg gtggttctaa gacagattgc tcatctgccg cactgtcaga aattactctc     1500

ttgtacagga cattttccac atccacacct tctcttcctg ctttgagtat tttagaggac     1560

tgtgcctcgt agtaagaaaa aaatgaaact cagtttcttg aaccacagga cagggccagc     1620

tctaacccca atgctacttc tagctcctct caggaccctg agagcctgca ggacaggggg     1680

gagggcaagg tggccaccac tgtgatctct aagatgctgt ttgtggagcc catcctggag     1740

gtgagcagcc tgcccaccac caacagcacc accaactctg ccactaagat cactgccaac     1800

accactgatg agcccaccac ccagcccact actgagccca ccacccagcc tactatccag     1860

cccacccagc ccactaccca gctgcccact gacagcccta cccagcccac cactggcagc     1920

ttctgccctg ggcctgtgac cctgtgctct gacctggaga gccattctac tgaggctgtg     1980

ctgggggatg ccctggtgga cttctctctg aagctgtacc atgctttctc tgccatgaag     2040

aaggtggaga ctaacatggc ttttagcccc ttcagcattg ctagcctgct gacccaggtg     2100

ctgctggggg ctggggagaa cactaagacc aacctggaat ctatcctgag ctaccccaag     2160

gacttcacct gtgtgcacca ggccctgaag ggcttcacca ccaagggggt gacctctgtg     2220

agccagatct tccacagccc tgacctggcc atcagggata cttttgtgaa tgccagcaga     2280

accctgtact cttctagccc cagggtgctg agcaataatt ctgatgctaa cctggagctg     2340

atcaatacct gggtggctaa gaataccaac aacaagatta gcaggctgct ggactctctg     2400

ccttctgata ccaggctggt gctgctgaat gccatttacc tgtctgccaa gtggaagacc     2460

acttttgacc ctaagaagac taggatggag cctttccact tcaagaactc tgtcattaag     2520

gtgcccatga tgaacagcaa gaagtatcct gtggcccact ttattgacca gactctgaag     2580

gccaaggtgg gccagctgca gctgagccat aacctgagcc tggtgatcct ggtgccccag     2640

aacctgaagc ataggctgga ggacatggag caggctctga gcccctctgt gttcaaggct     2700

attatggaga agctggagat gagcaagttc cagcccactc tgctgaccct gcccagaatc     2760

aaggtgacca cctctcagga catgctgagc atcatggaaa agctggagtt ctttgacttt     2820

tcttatgacc tgaatctgtg tggcctgact gaggatcctg atctgcaggt gtctgccatg     2880

cagcaccaga ctgtgctgga gctgactgag actggggtgg aggctgctgc tgcttctgcc     2940

atctctgtgg ccaggaccct gctggtgttt gaggtgcagc agcccttcct gtttgtgctg     3000

tgggaccagc agcacaagtt tcctgtgttc atgggcaggg tgtatgaccc cagagcctga     3060


<210>  147
<211>  3160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1co21(Intron 3-4)

<400>  147
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggacagggcc       60

agctctaacc ccaatgctac ttctagctcc tctcaggacc ctgagagcct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc tctaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac caccaacagc accaccaact ctgccactaa gatcactgcc      240

aacaccactg atgagcccac cacccagccc actactgagc ccaccaccca gcctactatc      300

cagcccaccc agcccactac ccagctgccc actgacagcc ctacccagcc caccactggc      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg agagccattc tactgaggct      420

gtgctggggg atgccctggt ggacttctct ctgaagctgt accatgcttt ctctgccatg      480

aagaaggtgg agactaacat ggcttttagc cccttcagca ttgctagcct gctgacccag      540

gtgctgctgg gtaagaccct gcttgaattc tctccaggtc atttgttgga cactcccata      600

agagtcacca atccagacac ttacaaagcc atgcctctgg gaagaagctg taaaaatggg      660

ctattatata ttgggggtgg ggtagaggga tgtatctttt cattcttgaa cattccatca      720

tttcacagtg atgtaatagg cacgattgct tgtaaaactc tgtgactata caagaacata      780

taaaataagg tcgcagccac taaccatgtt tcatggcaag gagaggtgat aagaaagatg      840

aaattaggcg cagtggctca cgcctgtaat cccagcactt tgggaggcca aggcgggtgg      900

atcacctgag gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ctgtctctac      960

taaaaataca aaaattatca gggagtggtg gtgcatgcct gtaatcccag ctacttgggc     1020

agctgaggca ggagaatcgc ttgaacccag gaggtggagg ttgcagtgag ccgagaccgc     1080

accattgcac tacagtctgg gtgacagagc gagactctgt ctcaaaaaaa aaaaaaaatt     1140

atcagagata gacctagagt agatgtggtt agtactgcct tctagctctg tgaccttggg     1200

cagatcactt taacctctct gagccttgag tcctcttgtg taaaatagtg atgatgctat     1260

ctacctcaaa agattaagaa gcagaaagcc aggccggatg cggtggttca cacctgtaat     1320

cccagcattt taggaggccg aggcgggcag atcacgaggt caggagttcg agaccagcct     1380

gactaacatg gtgaaacccc gtctctacta aaaataaaaa gaaattagct aggcatggtg     1440

gtgcacacct gtaaccccag ctactcagga ggctgaggca ggagaatcac ttgaacacgg     1500

gaggcagagg ttgcagtgag ccgaaatcat gccactgcac tccagcctgg gaagactgag     1560

caagactctg tctcaaaaaa aaaaaagaag cagcctagtg tctgacttag tgggaggtca     1620

aaaaaatgta aatcctctgc catcttgagg gattactgtc aagtcccatt tggtaattac     1680

cctaggaatg gcacaaacaa attactacaa gcagtgggga cagagctatt actccccaga     1740

gagaattcta aaaaggctac agaatctttc ttggctgggc acggtgactc acacctataa     1800

tcctggcact ttgggaggcc aaggcaggag ttcaagacca gcctggccaa catgttgaaa     1860

ccccatctct actaaaaatg caaaaattag ccaggcatag tgatgcatgc ttattgtccc     1920

agctacttgg gaggcagagg tgggaggatt gcttgaacct ggagattcaa gtgagctgag     1980

attgcaccac tgcattccag cctgggcaac aaagcaagac tctgtctcaa aaaaaaaaaa     2040

aaaaaaaaaa aaaagagaga ttgagagaac acttccagct cagatgatct gtgatcccct     2100

ccaaagcagg gaataccctc cattccagcc tggtccccaa ccctcattcc caaggaaggc     2160

ccccgactca tcctgcaagt atctttcatc tctgcccttt gttgcagggg ctggggagaa     2220

cactaagacc aacctggaat ctatcctgag ctaccccaag gacttcacct gtgtgcacca     2280

ggccctgaag ggcttcacca ccaagggggt gacctctgtg agccagatct tccacagccc     2340

tgacctggcc atcagggata cttttgtgaa tgccagcaga accctgtact cttctagccc     2400

cagggtgctg agcaataatt ctgatgctaa cctggagctg atcaatacct gggtggctaa     2460

gaataccaac aacaagatta gcaggctgct ggactctctg ccttctgata ccaggctggt     2520

gctgctgaat gccatttacc tgtctgccaa gtggaagacc acttttgacc ctaagaagac     2580

taggatggag cctttccact tcaagaactc tgtcattaag gtgcccatga tgaacagcaa     2640

gaagtatcct gtggcccact ttattgacca gactctgaag gccaaggtgg gccagctgca     2700

gctgagccat aacctgagcc tggtgatcct ggtgccccag aacctgaagc ataggctgga     2760

ggacatggag caggctctga gcccctctgt gttcaaggct attatggaga agctggagat     2820

gagcaagttc cagcccactc tgctgaccct gcccagaatc aaggtgacca cctctcagga     2880

catgctgagc atcatggaaa agctggagtt ctttgacttt tcttatgacc tgaatctgtg     2940

tggcctgact gaggatcctg atctgcaggt gtctgccatg cagcaccaga ctgtgctgga     3000

gctgactgag actggggtgg aggctgctgc tgcttctgcc atctctgtgg ccaggaccct     3060

gctggtgttt gaggtgcagc agcccttcct gtttgtgctg tgggaccagc agcacaagtt     3120

tcctgtgttc atgggcaggg tgtatgaccc cagagcctga                           3160


<210>  148
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_Exon1

<400>  148
agtctgcact ggagctgcct ggtgaccaga agtttgga                               38


<210>  149
<211>  548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_Intron1

<400>  149
gtaggtttgg tgctgggcag gggtggggag tagggtggaa agcatggagt gaagaggtct       60

agggaggggg tctcctcacc cccgccttcc tgcccgcctt gatctcgggg gtctctatag      120

gcttgcttcc acctgggact tctgcctcct cctaccccag cccctcccgc ctcaggcctg      180

ttgtgctcag ccccccagga cctcccctcc cccacgcctc tggcctcatt gtttggttaa      240

agcaggaccc cctccccctc ccaccacctc ccctccgact gaacagatgg acagagaccc      300

gggcccacgg ggagaggaag ggccagccgg tgccgggaaa gggaagcggt ttggggaaaa      360

caaaacagag ggaggagcca gggagaaggt ggccccagga gggaggagga gggaattcgc      420

taagagggac tggggcctga gacggaatgg gggcgggccc cgggcggggt gggggcccct      480

gggctcccag ggtgggagct ggctccgagg ctggctggct ccgcaggtcc gctgacgtcg      540

ccgcccag                                                               548


<210>  150
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_Intron2

<400>  150
gtatgtggtc ccttgtggga tgggggacgg gggtggagac gggaggcggg atggtgcggg       60

gtgcgggcgg tggctgagga ttaacccttc aggctccggg gaatgaggag agctcctctt      120

gggatcattg agtgtgatcc ttgcacacgc actcgtagat ggtggaaaga gctcaggact      180

cagacagatg caagttctaa tcttggcggg ccatgtagga gctgcgcagc gtggtcctga      240

ggacgtcact tttctcagcc tactcctcct gatttataaa atgttgaata aacagatccc      300

accctgtcca ccaagcaggc ttggcaggag gatcacatag ggcaaggaga tgggaagcat      360

tttgtgatat caaagcaaga gtttgttgta gaaaagagct gtggggagga gaggtttggc      420

tgctgtgaca cagacggtgg tcccaggcta gggcctgtga agacagggaa gaatggtagc      480

aaacatacgt gggtctgggt gggggtcaat agcagtgaga ggtcccagtg gtctgggagg      540

tcatggacta gaaataaggc taagaagtgc aggatcccag gagaaaggta ggtaggggtg      600

tgtgtatgtg cgtgtgtgtg tgtgtgcacg cgcaagttgg tatcacatac tcagcagatg      660

atgtagttat gagcagggag tttggaatca gagaccttgt tttgacccct agctgtttct      720

cccatttctg tgagaccctg gactagttaa tatgtgtcgg tatgagtttc tctacctgtg      780

aaatggagct aatgcgtggt ttctcagtgg aggatctgtt gacattgggg ctggataatt      840

cattgctgag gggctaccct gcgcatttta ggatgttttg cagtatatct ctagcctcta      900

cgcactagat tccggtagca tcttccctgc tgtctccctg tgacaaccaa aaatgtctct      960

ggacattgcc aaatatcccc tgggagtcaa aattgtttca gagccgctgg cctatactac     1020

ttctctctcc ctcccttcct gcctcccttc tttcctcctt ccctttcttc gttcccttcc     1080

taatgtgtac tgtttttcca cacccactaa tgggttgcaa cccacagttt aaaaatttac     1140

tgttctaaat caaggagcac aagttcaaat gtctgtacta gccaagcaag tgagtcaaac     1200

aggtagatat ttacaggaaa ttgcaagaac atagataaat gacaacactc agcttcactg     1260

tttggaaaac aacttcctac agggcagtaa ttggtcagag attacagagt ccctgactat     1320

ccctcatctt ctgcagagca cattcctgtg cacccccacc ctcaccctgt attgcccctt     1380

ctctgaggaa ttagtggtgg tggttctaag acagattgct catctgccgc actgtcagaa     1440

attactctct tgtacaggac attttccaca tccacacctt ctcttcctgc tttgagtatt     1500

ttagaggact gtgcctcgta gtaagaaaaa aatgaaactc agtttcttga accacag        1557


<210>  151
<211>  959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_Intron2(-LINE/SINE)

<400>  151
gtatgtggtc ccttgtggga tgggggacgg gggtggagac gggaggcggg atggtgcggg       60

gtgcgggcgg tggctgagga ttaacccttc aggctccggg gaatgaggag agctcctctt      120

gggatcattg agtgtgatcc ttgcacacgc actcgtagat gtatcaaagc aagagtttgt      180

tgtagaaaag agctgtgggg aggagaggtt tggctgctgt gacacagacg gtggtcccag      240

gctagggcct gtgaagacag ggaagaatgg tagcaaacat acgtgggtct gggtgggggt      300

caatagcagt gagaggtccc agtggtctgg gaggtcatgg actagaaata aggctaagaa      360

gtgcaggatc ccaggagaaa ggtaggtagg ggtgtgtgta tgtgcgtgtg tgtgtgtgtg      420

cacgcgcaag ttggtatcac atactcagcg tgcctatact acttctctct ccctcccttc      480

ctgcctccct tctttcctcc ttccctttct tcgttccctt cctaatgtgt actgtttttt      540

actgttctaa atcaaggagc acaagttcaa atgtctgtac tagccaagca agtgagtcaa      600

acaggtagat atttacagga aattgcaaga acatagataa atgacaacac tcagcttcac      660

tgtttggaaa acaacttcct acagggcagt aattggtcag agattacaga gtccctgact      720

atccctcatc ttctgcagag cacattcctg tgcaccccca ccctcaccct gtattgcccc      780

ttctctgagg aattagtggt ggtggttcta agacagattg ctcatctgcc gcactgtcag      840

aaattactct cttgtacagg acattttcca catccacacc ttctcttcct gctttgagta      900

ttttagagga ctgtgcctcg tagtaagaaa aaaatgaaac tcagtttctt gaaccacag       959


<210>  152
<211>  959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_Intron2(-LINE/SINE, -CpG)

<400>  152
gtatgtggtc ccttgtggga tgggggactg gggtggagag gggaggcagg atggtggggg       60

gtgcctgggg tggctgagga ttaacccttc aggctggggg gaatgaggag agctcctctt      120

gggatcattg agtgtgatcc ttgcacaggc actggtagat gtatcaaagc aagagtttgt      180

tgtagaaaag agctgtgggg aggagaggtt tggctgctgt gacacagagg gtggtcccag      240

gctagggcct gtgaagacag ggaagaatgg tagcaaacat aggtgggtct gggtgggggt      300

caatagcagt gagaggtccc agtggtctgg gaggtcatgg actagaaata aggctaagaa      360

gtgcaggatc ccaggagaaa ggtaggtagg ggtgtgtgta tgtgggtgtg tgtgtgtgtg      420

cacccccaag ttggtatcac atactcagcc tgcctatact acttctctct ccctcccttc      480

ctgcctccct tctttcctcc ttccctttct tccttccctt cctaatgtgt actgtttttt      540

actgttctaa atcaaggagc acaagttcaa atgtctgtac tagccaagca agtgagtcaa      600

acaggtagat atttacagga aattgcaaga acatagataa atgacaacac tcagcttcac      660

tgtttggaaa acaacttcct acagggcagt aattggtcag agattacaga gtccctgact      720

atccctcatc ttctgcagag cacattcctg tgcaccccca ccctcaccct gtattgcccc      780

ttctctgagg aattagtggt ggtggttcta agacagattg ctcatctgcc ccactgtcag      840

aaattactct cttgtacagg acattttcca catccacacc ttctcttcct gctttgagta      900

ttttagagga ctgtgcctgc tagtaagaaa aaaatgaaac tcagtttctt gaaccacag       959


<210>  153
<211>  1657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_Intron3

<400>  153
gtaagaccct gcttgaattc tctccaggtc atttgttgga cactcccata agagtcacca       60

atccagacac ttacaaagcc atgcctctgg gaagaagctg taaaaatggg ctattatata      120

ttgggggtgg ggtagaggga tgtatctttt cattcttgaa cattccatca tttcacagtg      180

atgtaatagg cacgattgct tgtaaaactc tgtgactata caagaacata taaaataagg      240

tcgcagccac taaccatgtt tcatggcaag gagaggtgat aagaaagatg aaattaggcg      300

cagtggctca cgcctgtaat cccagcactt tgggaggcca aggcgggtgg atcacctgag      360

gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ctgtctctac taaaaataca      420

aaaattatca gggagtggtg gtgcatgcct gtaatcccag ctacttgggc agctgaggca      480

ggagaatcgc ttgaacccag gaggtggagg ttgcagtgag ccgagaccgc accattgcac      540

tacagtctgg gtgacagagc gagactctgt ctcaaaaaaa aaaaaaaatt atcagagata      600

gacctagagt agatgtggtt agtactgcct tctagctctg tgaccttggg cagatcactt      660

taacctctct gagccttgag tcctcttgtg taaaatagtg atgatgctat ctacctcaaa      720

agattaagaa gcagaaagcc aggccggatg cggtggttca cacctgtaat cccagcattt      780

taggaggccg aggcgggcag atcacgaggt caggagttcg agaccagcct gactaacatg      840

gtgaaacccc gtctctacta aaaataaaaa gaaattagct aggcatggtg gtgcacacct      900

gtaaccccag ctactcagga ggctgaggca ggagaatcac ttgaacacgg gaggcagagg      960

ttgcagtgag ccgaaatcat gccactgcac tccagcctgg gaagactgag caagactctg     1020

tctcaaaaaa aaaaaagaag cagcctagtg tctgacttag tgggaggtca aaaaaatgta     1080

aatcctctgc catcttgagg gattactgtc aagtcccatt tggtaattac cctaggaatg     1140

gcacaaacaa attactacaa gcagtgggga cagagctatt actccccaga gagaattcta     1200

aaaaggctac agaatctttc ttggctgggc acggtgactc acacctataa tcctggcact     1260

ttgggaggcc aaggcaggag ttcaagacca gcctggccaa catgttgaaa ccccatctct     1320

actaaaaatg caaaaattag ccaggcatag tgatgcatgc ttattgtccc agctacttgg     1380

gaggcagagg tgggaggatt gcttgaacct ggagattcaa gtgagctgag attgcaccac     1440

tgcattccag cctgggcaac aaagcaagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa     1500

aaaagagaga ttgagagaac acttccagct cagatgatct gtgatcccct ccaaagcagg     1560

gaataccctc cattccagcc tggtccccaa ccctcattcc caaggaaggc ccccgactca     1620

tcctgcaagt atctttcatc tctgcccttt gttgcag                              1657


<210>  154
<211>  655
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_Intron3(-LINE/SINE)

<400>  154
gtaagaccct gcttgaattc tctccaggtc atttgttgga cactcccata agagtcacca       60

atccagacac ttacaaagcc atgcctctgg gaagaagctg taaaaatggg ctattatata      120

ttgggggtgg ggtagaggga tgtatctttt cattcttgaa cattccatca tttcacagtg      180

atgtaatagg cacgattgct tgtaaaactc tgtgactata caagaacata taaaataagg      240

tcgcagccac taaccatgtt tcatggcaag gagaggtgat aagaaagatg aaattattat      300

cagaagaagc agaaagccag cagcctagtg tctgacttag tgggaggtca aaaaaatgta      360

aatcctctgc catcttgagg gattactgtc aagtcccatt tggtaattac cctaggaatg      420

gcacaaacaa attactacaa gcagtgggga cagagctatt actccccaga gagaattcta      480

aaaaggctac agaatctttc ttgagagatt gagagaacac ttccagctca gatgatctgt      540

gatcccctcc aaagcaggga ataccctcca ttccagcctg gtccccaacc ctcattccca      600

aggaaggccc ccgactcatc ctgcaagtat ctttcatctc tgccctttgt tgcag           655


<210>  155
<211>  655
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_Intron3(-LINE/SINE, -CpG)

<400>  155
gtaagaccct gcttgaattc tctccaggtc atttgttgga cactcccata agagtcacca       60

atccagacac ttacaaagcc atgcctctgg gaagaagctg taaaaatggg ctattatata      120

ttgggggtgg ggtagaggga tgtatctttt cattcttgaa cattccatca tttcacagtg      180

atgtaatagg caccattgct tgtaaaactc tgtgactata caagaacata taaaataagg      240

tcccagccac taaccatgtt tcatggcaag gagaggtgat aagaaagatg aaattattat      300

cagaagaagc agaaagccag cagcctagtg tctgacttag tgggaggtca aaaaaatgta      360

aatcctctgc catcttgagg gattactgtc aagtcccatt tggtaattac cctaggaatg      420

gcacaaacaa attactacaa gcagtgggga cagagctatt actccccaga gagaattcta      480

aaaaggctac agaatctttc ttgagagatt gagagaacac ttccagctca gatgatctgt      540

gatcccctcc aaagcaggga ataccctcca ttccagcctg gtccccaacc ctcattccca      600

aggaaggccc cccactcatc ctgcaagtat ctttcatctc tgccctttgt tgcag           655


<210>  156
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1_coI21(-ORFs)

<400>  156
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggacagggcc       60

agctctaacc ccaatgctac ttctagctcc tctcaggacc ctgagagcct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc tctaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac caccaacagc accaccaact ctgccactaa gatcactgcc      240

aacaccactg atgagcccac cacccagccc actactgagc ccaccaccca gcctactatc      300

cagcccaccc agcccactac ccagctgccc actgacagcc ctacccagcc caccactggc      360

agcttctgcc ctgggcctgt gaccctgtgc tcagacctgg agagccactc tactgaggct      420

gtgctggggg atgccctggt ggacttctct ctgaagctgt atcatgcttt ctctgccatg      480

aagaaggtgg agactaacat ggcttttagc cccttcagca ttgctagcct gctgacccag      540

gtgctgctgg gggctgggga gaacactaag accaacctgg aatctatcct gagctacccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccaccaaggg ggtgacctct      660

gtgagccaga tcttccacag ccctgacctg gccatcaggg atacttttgt gaatgccagc      720

agaaccctgt actcttctag ccccagggtg ctgagcaata attctgatgc taacctggag      780

ctgatcaata cctgggtggc taagaatacc aacaacaaga ttagcaggct gctggactct      840

ctgccttctg ataccaggct ggtgctgctg aatgccattt acctgtctgc caagtggaag      900

accacttttg accctaagaa gactaggatg gagcctttcc acttcaagaa ctctgtcatt      960

aaggtgccca tgatgaacag caagaagtat cctgtggccc actttattga ccagactctg     1020

aaggccaagg tgggccagct gcagctgagc cacaacctga gcctggtgat cctggtgccc     1080

cagaacctga agcacaggct ggaggacatg gagcaggctc tgagcccctc tgtgttcaag     1140

gctattatgg agaagctgga gatgagcaag ttccagccca ctctgctgac cctgcccaga     1200

atcaaggtga ccacctctca ggacatgctg agcatcatgg aaaagctgga gttctttgac     1260

ttttcttatg acctgaatct gtgtggcctg actgaggatc ctgatctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcttct     1380

gccatctctg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gtttcctgtg ttcatgggca gggtgtatga ccccagagcc     1500

tga                                                                   1503


<210>  157
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  157
ggctctggtg ccaccaactt ctccctgctc aagcaggcag gggatgtgga agagaatcct       60

ggaccc                                                                  66


<210>  158
<211>  3069
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1co21.P2A.SERPING1co24

<400>  158
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggacagggcc       60

agctctaacc ccaatgctac ttctagctcc tctcaggacc ctgagagcct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc tctaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac caccaacagc accaccaact ctgccactaa gatcactgcc      240

aacaccactg atgagcccac cacccagccc actactgagc ccaccaccca gcctactatc      300

cagcccaccc agcccactac ccagctgccc actgacagcc ctacccagcc caccactggc      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg agagccattc tactgaggct      420

gtgctggggg atgccctggt ggacttctct ctgaagctgt accatgcttt ctctgccatg      480

aagaaggtgg agactaacat ggcttttagc cccttcagca ttgctagcct gctgacccag      540

gtgctgctgg gggctgggga gaacactaag accaacctgg aatctatcct gagctacccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccaccaaggg ggtgacctct      660

gtgagccaga tcttccacag ccctgacctg gccatcaggg atacttttgt gaatgccagc      720

agaaccctgt actcttctag ccccagggtg ctgagcaata attctgatgc taacctggag      780

ctgatcaata cctgggtggc taagaatacc aacaacaaga ttagcaggct gctggactct      840

ctgccttctg ataccaggct ggtgctgctg aatgccattt acctgtctgc caagtggaag      900

accacttttg accctaagaa gactaggatg gagcctttcc acttcaagaa ctctgtcatt      960

aaggtgccca tgatgaacag caagaagtat cctgtggccc actttattga ccagactctg     1020

aaggccaagg tgggccagct gcagctgagc cataacctga gcctggtgat cctggtgccc     1080

cagaacctga agcataggct ggaggacatg gagcaggctc tgagcccctc tgtgttcaag     1140

gctattatgg agaagctgga gatgagcaag ttccagccca ctctgctgac cctgcccaga     1200

atcaaggtga ccacctctca ggacatgctg agcatcatgg aaaagctgga gttctttgac     1260

ttttcttatg acctgaatct gtgtggcctg actgaggatc ctgatctgca ggtgtctgcc     1320

atgcagcacc agactgtgct ggagctgact gagactgggg tggaggctgc tgctgcttct     1380

gccatctctg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gtttcctgtg ttcatgggca gggtgtatga ccccagagct     1500

ggctctggtg ccaccaactt ctccctgctc aagcaggcag gggatgtgga agagaatcct     1560

ggacccatgg ctagcaggct gaccctgctg accctgctgc tcctgctgct ggctggggac     1620

agggcctcta gcaatcccaa tgccacctct agctctagcc aggatcctga gagcctgcag     1680

gacagggggg agggcaaggt ggccaccact gtgatcagca agatgctgtt tgtggagccc     1740

attctggagg tgtcttctct gcccaccacc aatagcacca ctaattctgc caccaagatc     1800

actgctaaca ccactgatga gcccaccact cagcctacca ctgagcccac cacccagccc     1860

actatccagc ccacccagcc caccacccag ctgcctactg acagccctac ccagcccact     1920

actgggagct tctgccctgg ccctgtgacc ctgtgctctg acctggagag ccacagcact     1980

gaggctgtgc tgggggatgc cctggtggac ttcagcctga agctgtacca tgccttttct     2040

gccatgaaga aggtggagac caacatggcc tttagccctt tcagcattgc cagcctgctg     2100

actcaggtgc tgctgggggc tggggagaac accaagacca acctggagag catcctgagc     2160

taccccaagg acttcacttg tgtgcaccag gccctgaagg gcttcactac caagggggtg     2220

acttctgtga gccagatctt ccacagccct gacctggcca tcagggatac ttttgtgaat     2280

gccagcagga ccctgtacag cagcagcccc agggtgctga gcaacaactc tgatgctaac     2340

ctggagctga tcaatacttg ggtggccaag aacaccaaca acaagatttc taggctgctg     2400

gactctctgc cctctgacac taggctggtg ctgctgaatg ccatctacct gtctgccaag     2460

tggaagacca cctttgatcc caagaagact aggatggagc ccttccactt caagaactct     2520

gtgatcaagg tgcccatgat gaacagcaag aagtaccctg tggcccattt cattgaccag     2580

accctgaagg ccaaggtggg gcagctgcag ctgagccaca atctgagcct ggtgattctg     2640

gtgccccaga atctgaagca cagactggag gacatggagc aggctctgtc tccctctgtg     2700

ttcaaggcca tcatggagaa gctggagatg agcaagttcc agcccactct gctgactctg     2760

cctaggatca aggtgaccac cagccaggac atgctgagca ttatggagaa gctggagttc     2820

tttgacttca gctatgacct gaacctgtgt ggcctgactg aggaccctga tctgcaggtg     2880

tctgccatgc agcaccagac tgtgctggag ctgactgaga ctggggtgga ggctgctgct     2940

gcctctgcta tttctgtggc caggaccctg ctggtgtttg aggtgcagca gcccttcctg     3000

tttgtgctgt gggaccagca gcacaagttt cctgtgttca tggggagggt gtatgacccc     3060

agggcctga                                                             3069


<210>  159
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(WT)

<400>  159
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggt                                                    678


<210>  160
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(Ishino)

<400>  160
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca atctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcaa tagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggt                                                    678


<210>  161
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(Ying)

<400>  161
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc aagcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctgagctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cggtgcccgt gctggactcc      540

gacggctcct tcagactcgc cagctacctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggt                                                    678


<210>  162
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(YTE)

<400>  162
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctctacatca cccgggagcc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggt                                                    678


<210>  163
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(LS)

<400>  163
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gctgcatgag gctctgcaca gccactacac gcagaagagc      660

ctctccctgt ctccgggt                                                    678


<210>  164
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc(IFL)

<400>  164
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgagatcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cttcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gctgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggt                                                    678


<210>  165
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc

<400>  165
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     1560

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     1620

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1680

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1740

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1800

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1860

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1920

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1980

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2040

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     2100

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2160

ctctccctgt ctccgggt                                                   2178


<210>  166
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(Ishino)

<400>  166
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     1560

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     1620

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1680

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1740

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1800

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1860

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1920

aaccaggtca atctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1980

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2040

gacggctcct tcttcctcaa tagcaagctc accgtggaca agagcaggtg gcagcagggg     2100

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2160

ctctccctgt ctccgggt                                                   2178


<210>  167
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(Ying)

<400>  167
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     1560

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     1620

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1680

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1740

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1800

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1860

gggcagcccc gagaaccaca ggtgtacacc aagcccccat cccgggatga gctgaccaag     1920

aaccaggtca gcctgagctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1980

tgggagagca atgggcagcc ggagaacaac tacaagacca cggtgcccgt gctggactcc     2040

gacggctcct tcagactcgc cagctacctc accgtggaca agagcaggtg gcagcagggg     2100

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2160

ctctccctgt ctccgggt                                                   2178


<210>  168
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(YTE)

<400>  168
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     1560

ttcctcttcc ccccaaaacc caaggacacc ctctacatca cccgggagcc tgaggtcaca     1620

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1680

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1740

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1800

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1860

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1920

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1980

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2040

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     2100

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2160

ctctccctgt ctccgggt                                                   2178


<210>  169
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(LS)

<400>  169
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     1560

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     1620

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1680

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1740

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1800

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1860

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1920

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1980

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2040

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     2100

aacgtcttct catgctccgt gctgcatgag gctctgcaca gccactacac gcagaagagc     2160

ctctccctgt ctccgggt                                                   2178


<210>  170
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(IFL)

<400>  170
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga ttttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc ctgatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     1560

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgagatcaca     1620

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1680

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1740

cgtgtggtca gcgtcctcac cttcctgcac caggactggc tgaatggcaa ggagtacaag     1800

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1860

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1920

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1980

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2040

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     2100

aacgtcttct catgctccgt gctgcatgag gctctgcaca accactacac gcagaagagc     2160

ctctccctgt ctccgggt                                                   2178


<210>  171
<211>  2462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1co21(Intron 2-3)(SINES_LINES)

<400>  171
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggtatgtggt       60

cccttgtggg atgggggacg ggggtggaga cgggaggcgg gatggtgcgg ggtgcgggcg      120

gtggctgagg attaaccctt caggctccgg ggaatgagga gagctcctct tgggatcatt      180

gagtgtgatc cttgcacacg cactcgtaga tgtatcaaag caagagtttg ttgtagaaaa      240

gagctgtggg gaggagaggt ttggctgctg tgacacagac ggtggtccca ggctagggcc      300

tgtgaagaca gggaagaatg gtagcaaaca tacgtgggtc tgggtggggg tcaatagcag      360

tgagaggtcc cagtggtctg ggaggtcatg gactagaaat aaggctaaga agtgcaggat      420

cccaggagaa aggtaggtag gggtgtgtgt atgtgcgtgt gtgtgtgtgt gcacgcgcaa      480

gttggtatca catactcagc gtgcctatac tacttctctc tccctccctt cctgcctccc      540

ttctttcctc cttccctttc ttcgttccct tcctaatgtg tactgttttt tactgttcta      600

aatcaaggag cacaagttca aatgtctgta ctagccaagc aagtgagtca aacaggtaga      660

tatttacagg aaattgcaag aacatagata aatgacaaca ctcagcttca ctgtttggaa      720

aacaacttcc tacagggcag taattggtca gagattacag agtccctgac tatccctcat      780

cttctgcaga gcacattcct gtgcaccccc accctcaccc tgtattgccc cttctctgag      840

gaattagtgg tggtggttct aagacagatt gctcatctgc cgcactgtca gaaattactc      900

tcttgtacag gacattttcc acatccacac cttctcttcc tgctttgagt attttagagg      960

actgtgcctc gtagtaagaa aaaaatgaaa ctcagtttct tgaaccacag gacagggcca     1020

gctctaaccc caatgctact tctagctcct ctcaggaccc tgagagcctg caggacaggg     1080

gggagggcaa ggtggccacc actgtgatct ctaagatgct gtttgtggag cccatcctgg     1140

aggtgagcag cctgcccacc accaacagca ccaccaactc tgccactaag atcactgcca     1200

acaccactga tgagcccacc acccagccca ctactgagcc caccacccag cctactatcc     1260

agcccaccca gcccactacc cagctgccca ctgacagccc tacccagccc accactggca     1320

gcttctgccc tgggcctgtg accctgtgct ctgacctgga gagccattct actgaggctg     1380

tgctggggga tgccctggtg gacttctctc tgaagctgta ccatgctttc tctgccatga     1440

agaaggtgga gactaacatg gcttttagcc ccttcagcat tgctagcctg ctgacccagg     1500

tgctgctggg ggctggggag aacactaaga ccaacctgga atctatcctg agctacccca     1560

aggacttcac ctgtgtgcac caggccctga agggcttcac caccaagggg gtgacctctg     1620

tgagccagat cttccacagc cctgacctgg ccatcaggga tacttttgtg aatgccagca     1680

gaaccctgta ctcttctagc cccagggtgc tgagcaataa ttctgatgct aacctggagc     1740

tgatcaatac ctgggtggct aagaatacca acaacaagat tagcaggctg ctggactctc     1800

tgccttctga taccaggctg gtgctgctga atgccattta cctgtctgcc aagtggaaga     1860

ccacttttga ccctaagaag actaggatgg agcctttcca cttcaagaac tctgtcatta     1920

aggtgcccat gatgaacagc aagaagtatc ctgtggccca ctttattgac cagactctga     1980

aggccaaggt gggccagctg cagctgagcc ataacctgag cctggtgatc ctggtgcccc     2040

agaacctgaa gcataggctg gaggacatgg agcaggctct gagcccctct gtgttcaagg     2100

ctattatgga gaagctggag atgagcaagt tccagcccac tctgctgacc ctgcccagaa     2160

tcaaggtgac cacctctcag gacatgctga gcatcatgga aaagctggag ttctttgact     2220

tttcttatga cctgaatctg tgtggcctga ctgaggatcc tgatctgcag gtgtctgcca     2280

tgcagcacca gactgtgctg gagctgactg agactggggt ggaggctgct gctgcttctg     2340

ccatctctgt ggccaggacc ctgctggtgt ttgaggtgca gcagcccttc ctgtttgtgc     2400

tgtgggacca gcagcacaag tttcctgtgt tcatgggcag ggtgtatgac cccagagcct     2460

ga                                                                    2462


<210>  172
<211>  2158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1co21(Intron 3-4)(SINES_LINES)

<400>  172
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggacagggcc       60

agctctaacc ccaatgctac ttctagctcc tctcaggacc ctgagagcct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc tctaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac caccaacagc accaccaact ctgccactaa gatcactgcc      240

aacaccactg atgagcccac cacccagccc actactgagc ccaccaccca gcctactatc      300

cagcccaccc agcccactac ccagctgccc actgacagcc ctacccagcc caccactggc      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg agagccattc tactgaggct      420

gtgctggggg atgccctggt ggacttctct ctgaagctgt accatgcttt ctctgccatg      480

aagaaggtgg agactaacat ggcttttagc cccttcagca ttgctagcct gctgacccag      540

gtgctgctgg gtaagaccct gcttgaattc tctccaggtc atttgttgga cactcccata      600

agagtcacca atccagacac ttacaaagcc atgcctctgg gaagaagctg taaaaatggg      660

ctattatata ttgggggtgg ggtagaggga tgtatctttt cattcttgaa cattccatca      720

tttcacagtg atgtaatagg cacgattgct tgtaaaactc tgtgactata caagaacata      780

taaaataagg tcgcagccac taaccatgtt tcatggcaag gagaggtgat aagaaagatg      840

aaattattat cagaagaagc agaaagccag cagcctagtg tctgacttag tgggaggtca      900

aaaaaatgta aatcctctgc catcttgagg gattactgtc aagtcccatt tggtaattac      960

cctaggaatg gcacaaacaa attactacaa gcagtgggga cagagctatt actccccaga     1020

gagaattcta aaaaggctac agaatctttc ttgagagatt gagagaacac ttccagctca     1080

gatgatctgt gatcccctcc aaagcaggga ataccctcca ttccagcctg gtccccaacc     1140

ctcattccca aggaaggccc ccgactcatc ctgcaagtat ctttcatctc tgccctttgt     1200

tgcaggggct ggggagaaca ctaagaccaa cctggaatct atcctgagct accccaagga     1260

cttcacctgt gtgcaccagg ccctgaaggg cttcaccacc aagggggtga cctctgtgag     1320

ccagatcttc cacagccctg acctggccat cagggatact tttgtgaatg ccagcagaac     1380

cctgtactct tctagcccca gggtgctgag caataattct gatgctaacc tggagctgat     1440

caatacctgg gtggctaaga ataccaacaa caagattagc aggctgctgg actctctgcc     1500

ttctgatacc aggctggtgc tgctgaatgc catttacctg tctgccaagt ggaagaccac     1560

ttttgaccct aagaagacta ggatggagcc tttccacttc aagaactctg tcattaaggt     1620

gcccatgatg aacagcaaga agtatcctgt ggcccacttt attgaccaga ctctgaaggc     1680

caaggtgggc cagctgcagc tgagccataa cctgagcctg gtgatcctgg tgccccagaa     1740

cctgaagcat aggctggagg acatggagca ggctctgagc ccctctgtgt tcaaggctat     1800

tatggagaag ctggagatga gcaagttcca gcccactctg ctgaccctgc ccagaatcaa     1860

ggtgaccacc tctcaggaca tgctgagcat catggaaaag ctggagttct ttgacttttc     1920

ttatgacctg aatctgtgtg gcctgactga ggatcctgat ctgcaggtgt ctgccatgca     1980

gcaccagact gtgctggagc tgactgagac tggggtggag gctgctgctg cttctgccat     2040

ctctgtggcc aggaccctgc tggtgtttga ggtgcagcag cccttcctgt ttgtgctgtg     2100

ggaccagcag cacaagtttc ctgtgttcat gggcagggtg tatgacccca gagcctga       2158


<210>  173
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAAT enhancer

<400>  173
cctgcagtct tcagagggcc accgcagctc cagtgccacg gcaggaggct gttcctgaat       60

agcccctgtg gtaagggcca ggagagtcct tccatcctcc aaggccctgc taaaggacac      120

agcagccagg aagtcccctg ggcccctagc tgaaggacag cctgctccct ccgtctctac      180

caggaatggc cttgtcctat ggaaggcact gccccatccc aaactaatct aggaatcact      240

gtctaaccac tcactgtcat gaatgtgtac ttaaaggatg aggttgagtc ataccaaata      300

gtgatttcga tagttcaaaa tggtgaaatt agcaattcta catgattcag tctaatcaat      360

ggataccgac tgtttcccac acaagtctcc tgttctctta agcttactca ctgacagcct      420

ttcactctcc acaaatacat taaagatatg gccatcacca agccccctag gatgacacca      480

gacctgagag tctgaagacc tggatcc                                          507


<210>  174
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hAAT enhancer(-CpG)

<400>  174
cctgcagtct tcagagggcc actgcagctc cagtgccatg gcaggaggct gttcctgaat       60

agcccctgtg gtaagggcca ggagagtcct tccatcctcc aaggccctgc taaaggacac      120

agcagccagg aagtcccctg ggcccctagc tgaaggacag cctgctccct ctgtctctac      180

caggaatggc cttgtcctat ggaaggcact gccccatccc aaactaatct aggaatcact      240

gtctaaccac tcactgtcat gaatgtgtac ttaaaggatg aggttgagtc ataccaaata      300

gtgattttga tagttcaaaa tggtgaaatt agcaattcta catgattcag tctaatcaat      360

ggatactgac tgtttcccac acaagtctcc tgttctctta agcttactca ctgacagcct      420

ttcactctcc acaaatacat taaagatatg gccatcacca agccccctag gatgacacca      480

gacctgagag tctgaagacc tggatcc                                          507


<210>  175
<211>  247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE3

<400>  175
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggtgt                                                                247


<210>  176
<211>  247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE3(-CpG)

<400>  176
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttatgc tatgtggata tgctgcttta atgcctttgt atcatgctat tgcttcctgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccat ggtggaactc      180

attgctgcct gccttgcctg ctgctggaca ggggcttggc tgttgggcac tgacaattct      240

gtggtgt                                                                247


<210>  177
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  177
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  178
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE(-CpG)

<400>  178
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttatgc tatgtggata tgctgcttta atgcctttgt atcatgctat tgcttcctgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcctgttg tcaggcaatg tggtgtggtg tgcactgtgt ttgctgatgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttctggga cttttgcttt ccccctccct      300

attgccatgg tggaactcat tgctgcctgc cttgcctgct gctggacagg ggcttggctg      360

ttgggcactg acaattctgt ggtgttgttg gggaagctga tgtcctttcc atggctgctt      420

gcctgtgttg ccacctggat tctgtgtggg atgtccttct gctatgtccc tttggccctc      480

aatccagtgg accttccttc ctgtggcctg ctgctggctc tgtggcctct tctgtgtctt      540

tgcctttgcc ctcagatgag ttggatctcc ctttgggctg cctccctgc                  589


<210>  179
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4xmir-142-3p

<400>  179
tccataaagt aggaaacact acaccattcc ataaagtagg aaacactaca accagttcca       60

taaagtagga aacactacat cactccataa agtaggaaac actaca                     106


<210>  180
<211>  586
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1 5' UTR

<400>  180
agtctgcact ggagctgcct ggtgaccaga agtttggagt aggtttggtg ctgggcaggg       60

gtggggagta gggtggaaag catggagtga agaggtctag ggagggggtc tcctcacccc      120

cgccttcctg cccgccttga tctcgggggt ctctataggc ttgcttccac ctgggacttc      180

tgcctcctcc taccccagcc cctcccgcct caggcctgtt gtgctcagcc ccccaggacc      240

tcccctcccc cacgcctctg gcctcattgt ttggttaaag caggaccccc tccccctccc      300

accacctccc ctccgactga acagatggac agagacccgg gcccacgggg agaggaaggg      360

ccagccggtg ccgggaaagg gaagcggttt ggggaaaaca aaacagaggg aggagccagg      420

gagaaggtgg ccccaggagg gaggaggagg gaattcgcta agagggactg gggcctgaga      480

cggaatgggg gcgggccccg ggcggggtgg gggcccctgg gctcccaggg tgggagctgg      540

ctccgaggct ggctggctcc gcaggtccgc tgacgtcgcc gcccag                     586


<210>  181
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1 aa_sequence without SP

<400>  181

Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln Asp Pro Glu Ser Leu Gln 
1               5                   10                  15      


Asp Arg Gly Glu Gly Lys Val Ala Thr Thr Val Ile Ser Lys Met Leu 
            20                  25                  30          


Phe Val Glu Pro Ile Leu Glu Val Ser Ser Leu Pro Thr Thr Asn Ser 
        35                  40                  45              


Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala Asn Thr Thr Asp Glu Pro 
    50                  55                  60                  


Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr Gln Pro Thr Ile Gln Pro 
65                  70                  75                  80  


Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp Ser Pro Thr Gln Pro Thr 
                85                  90                  95      


Thr Gly Ser Phe Cys Pro Gly Pro Val Thr Leu Cys Ser Asp Leu Glu 
            100                 105                 110         


Ser His Ser Thr Glu Ala Val Leu Gly Asp Ala Leu Val Asp Phe Ser 
        115                 120                 125             


Leu Lys Leu Tyr His Ala Phe Ser Ala Met Lys Lys Val Glu Thr Asn 
    130                 135                 140                 


Met Ala Phe Ser Pro Phe Ser Ile Ala Ser Leu Leu Thr Gln Val Leu 
145                 150                 155                 160 


Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn Leu Glu Ser Ile Leu Ser 
                165                 170                 175     


Tyr Pro Lys Asp Phe Thr Cys Val His Gln Ala Leu Lys Gly Phe Thr 
            180                 185                 190         


Thr Lys Gly Val Thr Ser Val Ser Gln Ile Phe His Ser Pro Asp Leu 
        195                 200                 205             


Ala Ile Arg Asp Thr Phe Val Asn Ala Ser Arg Thr Leu Tyr Ser Ser 
    210                 215                 220                 


Ser Pro Arg Val Leu Ser Asn Asn Ser Asp Ala Asn Leu Glu Leu Ile 
225                 230                 235                 240 


Asn Thr Trp Val Ala Lys Asn Thr Asn Asn Lys Ile Ser Arg Leu Leu 
                245                 250                 255     


Asp Ser Leu Pro Ser Asp Thr Arg Leu Val Leu Leu Asn Ala Ile Tyr 
            260                 265                 270         


Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp Pro Lys Lys Thr Arg Met 
        275                 280                 285             


Glu Pro Phe His Phe Lys Asn Ser Val Ile Lys Val Pro Met Met Asn 
    290                 295                 300                 


Ser Lys Lys Tyr Pro Val Ala His Phe Ile Asp Gln Thr Leu Lys Ala 
305                 310                 315                 320 


Lys Val Gly Gln Leu Gln Leu Ser His Asn Leu Ser Leu Val Ile Leu 
                325                 330                 335     


Val Pro Gln Asn Leu Lys His Arg Leu Glu Asp Met Glu Gln Ala Leu 
            340                 345                 350         


Ser Pro Ser Val Phe Lys Ala Ile Met Glu Lys Leu Glu Met Ser Lys 
        355                 360                 365             


Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg Ile Lys Val Thr Thr Ser 
    370                 375                 380                 


Gln Asp Met Leu Ser Ile Met Glu Lys Leu Glu Phe Phe Asp Phe Ser 
385                 390                 395                 400 


Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu Asp Pro Asp Leu Gln Val 
                405                 410                 415     


Ser Ala Met Gln His Gln Thr Val Leu Glu Leu Thr Glu Thr Gly Val 
            420                 425                 430         


Glu Ala Ala Ala Ala Ser Ala Ile Ser Val Ala Arg Thr Leu Leu Val 
        435                 440                 445             


Phe Glu Val Gln Gln Pro Phe Leu Phe Val Leu Trp Asp Gln Gln His 
    450                 455                 460                 


Lys Phe Pro Val Phe Met Gly Arg Val Tyr Asp Pro Arg Ala 
465                 470                 475             


<210>  182
<211>  371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1 APRE

<400>  182
ttgaggaata acggaggtga gcaatttcca aaaagttcat tcctttaaaa actgcggagc       60

acattttgtg tacatgctgt ttttattgtt actcatgaag acgcggggga agctttggtt      120

gtgtaaagct gagaactgca cccaagcttc cccgttcacc ccacctacca ggggatttgg      180

gctaaattcc tggcctggcc cacaaagaag accaagcggt cagtcccatt ccgtcccatc      240

ctgatttaca ggaactcaca ccagcgatca atcttcctta atttgtaact gggcagtgtc      300

ccgggccagc caatagctaa gactgccccc cccgcacccc accctccctg accctggggg      360

actctctact c                                                           371


<210>  183
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SAA2 5' UTR

<400>  183
agggacccgc agctcagcta cagcacagat cag                                    33


<210>  184
<211>  137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SAA2 3' UTR

<400>  184
gcttcctctt cactctgctc tcaggagacc tggctatgag gccctcgggg cagggataca       60

aagttagtga ggtctatgtc cagagaagct gagatatggc atataatagg catctaataa      120

atgcttaaga ggtggaa                                                     137


<210>  185
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1xRIDD

<400>  185
gcacctctgc agcagg                                                       16


<210>  186
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3xRIDD

<400>  186
gcacctctgc agcaggaagt ctctgcagaa gataacacct gcagagtg                    48


<210>  187
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BlosRIDD

<400>  187
ctacaaaggg cagctgcagt ctgccccttc cta                                    33


<210>  188
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1

<400>  188

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  189
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP2

<400>  189

Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Pro Ser Pro Gln Arg Ser 
1               5                   10                  15      


Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln Gln Pro Ala Lys 
            20                  25                  30          


Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser Val Pro Asp 
        35                  40                  45              


Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser Gly Leu Gly Ser 
    50                  55                  60                  


Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu 
65                  70                  75                  80  


Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser 
                85                  90                  95      


Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala 
            100                 105                 110         


Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr 
        115                 120                 125             


Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro 
    130                 135                 140                 


Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg 
145                 150                 155                 160 


Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg 
                165                 170                 175     


Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn 
            180                 185                 190         


Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val 
        195                 200                 205             


Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His 
    210                 215                 220                 


Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln 
225                 230                 235                 240 


Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser 
                245                 250                 255     


Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
            260                 265                 270         


Asn Asn Phe Glu Phe Ser Tyr Asn Phe Glu Asp Val Pro Phe His Ser 
        275                 280                 285             


Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
    290                 295                 300                 


Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly Gly Thr 
305                 310                 315                 320 


Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn Asn Met 
                325                 330                 335     


Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
            340                 345                 350         


Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe Ala Trp 
        355                 360                 365             


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn 
    370                 375                 380                 


Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe 
385                 390                 395                 400 


Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly Lys Asp 
                405                 410                 415     


Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu Ile Lys 
            420                 425                 430         


Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala Asp Asn 
        435                 440                 445             


Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn Ser Gln 
    450                 455                 460                 


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
465                 470                 475                 480 


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
                485                 490                 495     


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
            500                 505                 510         


Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn 
        515                 520                 525             


Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
    530                 535                 540                 


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
545                 550                 555                 560 


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Asn Val 
                565                 570                 575     


Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg Pro Ile 
            580                 585                 590         


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
        595                 600     


<210>  190
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP3

<400>  190

Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly 
    50                  55                  60                  


Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
65                  70                  75                  80  


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
                85                  90                  95      


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
            100                 105                 110         


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly 
        115                 120                 125             


Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr 
    130                 135                 140                 


Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly 
145                 150                 155                 160 


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
                165                 170                 175     


Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
            180                 185                 190         


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
        195                 200                 205             


Phe Glu Phe Ser Tyr Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr 
    210                 215                 220                 


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
225                 230                 235                 240 


Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly 
                245                 250                 255     


Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala 
            260                 265                 270         


Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val 
        275                 280                 285             


Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly 
    290                 295                 300                 


Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly 
305                 310                 315                 320 


Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser 
                325                 330                 335     


Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val 
            340                 345                 350         


Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr 
        355                 360                 365             


Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln 
    370                 375                 380                 


Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala 
385                 390                 395                 400 


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro 
                405                 410                 415     


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
            420                 425                 430         


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
        435                 440                 445             


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala 
    450                 455                 460                 


Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
465                 470                 475                 480 


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
                485                 490                 495     


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe 
            500                 505                 510         


Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
        515                 520                 525             


Arg Tyr Leu Thr Arg Asn Leu 
    530                 535 


<210>  191
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1

<400>  191

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  192
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1 aa sequence

<400>  192

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  193
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  delta76.SERPING1 aa sequence

<400>  193

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Thr Ile Gln Pro Thr Gln Pro Thr 
            20                  25                  30          


Thr Gln Leu Pro Thr Asp Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe 
        35                  40                  45              


Cys Pro Gly Pro Val Thr Leu Cys Ser Asp Leu Glu Ser His Ser Thr 
    50                  55                  60                  


Glu Ala Val Leu Gly Asp Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr 
65                  70                  75                  80  


His Ala Phe Ser Ala Met Lys Lys Val Glu Thr Asn Met Ala Phe Ser 
                85                  90                  95      


Pro Phe Ser Ile Ala Ser Leu Leu Thr Gln Val Leu Leu Gly Ala Gly 
            100                 105                 110         


Glu Asn Thr Lys Thr Asn Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp 
        115                 120                 125             


Phe Thr Cys Val His Gln Ala Leu Lys Gly Phe Thr Thr Lys Gly Val 
    130                 135                 140                 


Thr Ser Val Ser Gln Ile Phe His Ser Pro Asp Leu Ala Ile Arg Asp 
145                 150                 155                 160 


Thr Phe Val Asn Ala Ser Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val 
                165                 170                 175     


Leu Ser Asn Asn Ser Asp Ala Asn Leu Glu Leu Ile Asn Thr Trp Val 
            180                 185                 190         


Ala Lys Asn Thr Asn Asn Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro 
        195                 200                 205             


Ser Asp Thr Arg Leu Val Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys 
    210                 215                 220                 


Trp Lys Thr Thr Phe Asp Pro Lys Lys Thr Arg Met Glu Pro Phe His 
225                 230                 235                 240 


Phe Lys Asn Ser Val Ile Lys Val Pro Met Met Asn Ser Lys Lys Tyr 
                245                 250                 255     


Pro Val Ala His Phe Ile Asp Gln Thr Leu Lys Ala Lys Val Gly Gln 
            260                 265                 270         


Leu Gln Leu Ser His Asn Leu Ser Leu Val Ile Leu Val Pro Gln Asn 
        275                 280                 285             


Leu Lys His Arg Leu Glu Asp Met Glu Gln Ala Leu Ser Pro Ser Val 
    290                 295                 300                 


Phe Lys Ala Ile Met Glu Lys Leu Glu Met Ser Lys Phe Gln Pro Thr 
305                 310                 315                 320 


Leu Leu Thr Leu Pro Arg Ile Lys Val Thr Thr Ser Gln Asp Met Leu 
                325                 330                 335     


Ser Ile Met Glu Lys Leu Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn 
            340                 345                 350         


Leu Cys Gly Leu Thr Glu Asp Pro Asp Leu Gln Val Ser Ala Met Gln 
        355                 360                 365             


His Gln Thr Val Leu Glu Leu Thr Glu Thr Gly Val Glu Ala Ala Ala 
    370                 375                 380                 


Ala Ser Ala Ile Ser Val Ala Arg Thr Leu Leu Val Phe Glu Val Gln 
385                 390                 395                 400 


Gln Pro Phe Leu Phe Val Leu Trp Asp Gln Gln His Lys Phe Pro Val 
                405                 410                 415     


Phe Met Gly Arg Val Tyr Asp Pro Arg Ala 
            420                 425     


<210>  194
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  delta98.SERPING1 aa sequence

<400>  194

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Gly Ser Phe Cys Pro Gly Pro Val Thr 
            20                  25                  30          


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
        35                  40                  45              


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
    50                  55                  60                  


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
65                  70                  75                  80  


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
                85                  90                  95      


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
            100                 105                 110         


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
        115                 120                 125             


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
    130                 135                 140                 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
145                 150                 155                 160 


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
                165                 170                 175     


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
            180                 185                 190         


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
        195                 200                 205             


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
    210                 215                 220                 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
225                 230                 235                 240 


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
                245                 250                 255     


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
            260                 265                 270         


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
        275                 280                 285             


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
    290                 295                 300                 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
305                 310                 315                 320 


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
                325                 330                 335     


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
            340                 345                 350         


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
        355                 360                 365             


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
    370                 375                 380                 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
385                 390                 395                 400 


Asp Pro Arg Ala 
                


<210>  195
<211>  1022
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1co21.P2A.SERPING1co24 aa sequence

<400>  195

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
            500                 505                 510         


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser Arg Leu Thr 
        515                 520                 525             


Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala Gly Asp Arg Ala Ser Ser 
    530                 535                 540                 


Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln Asp Pro Glu Ser Leu Gln 
545                 550                 555                 560 


Asp Arg Gly Glu Gly Lys Val Ala Thr Thr Val Ile Ser Lys Met Leu 
                565                 570                 575     


Phe Val Glu Pro Ile Leu Glu Val Ser Ser Leu Pro Thr Thr Asn Ser 
            580                 585                 590         


Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala Asn Thr Thr Asp Glu Pro 
        595                 600                 605             


Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr Gln Pro Thr Ile Gln Pro 
    610                 615                 620                 


Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp Ser Pro Thr Gln Pro Thr 
625                 630                 635                 640 


Thr Gly Ser Phe Cys Pro Gly Pro Val Thr Leu Cys Ser Asp Leu Glu 
                645                 650                 655     


Ser His Ser Thr Glu Ala Val Leu Gly Asp Ala Leu Val Asp Phe Ser 
            660                 665                 670         


Leu Lys Leu Tyr His Ala Phe Ser Ala Met Lys Lys Val Glu Thr Asn 
        675                 680                 685             


Met Ala Phe Ser Pro Phe Ser Ile Ala Ser Leu Leu Thr Gln Val Leu 
    690                 695                 700                 


Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn Leu Glu Ser Ile Leu Ser 
705                 710                 715                 720 


Tyr Pro Lys Asp Phe Thr Cys Val His Gln Ala Leu Lys Gly Phe Thr 
                725                 730                 735     


Thr Lys Gly Val Thr Ser Val Ser Gln Ile Phe His Ser Pro Asp Leu 
            740                 745                 750         


Ala Ile Arg Asp Thr Phe Val Asn Ala Ser Arg Thr Leu Tyr Ser Ser 
        755                 760                 765             


Ser Pro Arg Val Leu Ser Asn Asn Ser Asp Ala Asn Leu Glu Leu Ile 
    770                 775                 780                 


Asn Thr Trp Val Ala Lys Asn Thr Asn Asn Lys Ile Ser Arg Leu Leu 
785                 790                 795                 800 


Asp Ser Leu Pro Ser Asp Thr Arg Leu Val Leu Leu Asn Ala Ile Tyr 
                805                 810                 815     


Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp Pro Lys Lys Thr Arg Met 
            820                 825                 830         


Glu Pro Phe His Phe Lys Asn Ser Val Ile Lys Val Pro Met Met Asn 
        835                 840                 845             


Ser Lys Lys Tyr Pro Val Ala His Phe Ile Asp Gln Thr Leu Lys Ala 
    850                 855                 860                 


Lys Val Gly Gln Leu Gln Leu Ser His Asn Leu Ser Leu Val Ile Leu 
865                 870                 875                 880 


Val Pro Gln Asn Leu Lys His Arg Leu Glu Asp Met Glu Gln Ala Leu 
                885                 890                 895     


Ser Pro Ser Val Phe Lys Ala Ile Met Glu Lys Leu Glu Met Ser Lys 
            900                 905                 910         


Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg Ile Lys Val Thr Thr Ser 
        915                 920                 925             


Gln Asp Met Leu Ser Ile Met Glu Lys Leu Glu Phe Phe Asp Phe Ser 
    930                 935                 940                 


Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu Asp Pro Asp Leu Gln Val 
945                 950                 955                 960 


Ser Ala Met Gln His Gln Thr Val Leu Glu Leu Thr Glu Thr Gly Val 
                965                 970                 975     


Glu Ala Ala Ala Ala Ser Ala Ile Ser Val Ala Arg Thr Leu Leu Val 
            980                 985                 990         


Phe Glu Val Gln Gln Pro Phe Leu  Phe Val Leu Trp Asp  Gln Gln His 
        995                 1000                 1005             


Lys Phe  Pro Val Phe Met Gly  Arg Val Tyr Asp Pro  Arg Ala 
    1010                 1015                 1020         


<210>  196
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc aa sequence

<400>  196

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            500                 505                 510         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        515                 520                 525             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    530                 535                 540                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
545                 550                 555                 560 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                565                 570                 575     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            580                 585                 590         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        595                 600                 605             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    610                 615                 620                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
625                 630                 635                 640 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                645                 650                 655     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            660                 665                 670         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        675                 680                 685             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    690                 695                 700                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
705                 710                 715                 720 


Leu Ser Leu Ser Pro Gly 
                725     


<210>  197
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(Ishino) aa sequence

<400>  197

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            500                 505                 510         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        515                 520                 525             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    530                 535                 540                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
545                 550                 555                 560 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                565                 570                 575     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            580                 585                 590         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        595                 600                 605             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    610                 615                 620                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
625                 630                 635                 640 


Asn Gln Val Asn Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                645                 650                 655     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            660                 665                 670         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Asn Ser 
        675                 680                 685             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    690                 695                 700                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
705                 710                 715                 720 


Leu Ser Leu Ser Pro Gly 
                725     


<210>  198
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(Ying) aa sequence

<400>  198

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            500                 505                 510         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        515                 520                 525             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    530                 535                 540                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
545                 550                 555                 560 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                565                 570                 575     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            580                 585                 590         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        595                 600                 605             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    610                 615                 620                 


Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Asp Glu Leu Thr Lys 
625                 630                 635                 640 


Asn Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                645                 650                 655     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            660                 665                 670         


Thr Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser 
        675                 680                 685             


Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    690                 695                 700                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
705                 710                 715                 720 


Leu Ser Leu Ser Pro Gly 
                725     


<210>  199
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(YTE) aa sequence

<400>  199

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            500                 505                 510         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        515                 520                 525             


Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val 
    530                 535                 540                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
545                 550                 555                 560 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                565                 570                 575     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            580                 585                 590         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        595                 600                 605             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    610                 615                 620                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
625                 630                 635                 640 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                645                 650                 655     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            660                 665                 670         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        675                 680                 685             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    690                 695                 700                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
705                 710                 715                 720 


Leu Ser Leu Ser Pro Gly 
                725     


<210>  200
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(LS) aa sequence

<400>  200

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            500                 505                 510         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        515                 520                 525             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    530                 535                 540                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
545                 550                 555                 560 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                565                 570                 575     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            580                 585                 590         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        595                 600                 605             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    610                 615                 620                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
625                 630                 635                 640 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                645                 650                 655     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            660                 665                 670         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        675                 680                 685             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    690                 695                 700                 


Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser 
705                 710                 715                 720 


Leu Ser Leu Ser Pro Gly 
                725     


<210>  201
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1.Fc(IFL) aa sequence

<400>  201

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            500                 505                 510         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        515                 520                 525             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Ile Thr Cys Val Val Val 
    530                 535                 540                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
545                 550                 555                 560 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                565                 570                 575     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Phe Leu His Gln Asp 
            580                 585                 590         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        595                 600                 605             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    610                 615                 620                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
625                 630                 635                 640 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                645                 650                 655     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            660                 665                 670         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        675                 680                 685             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    690                 695                 700                 


Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
705                 710                 715                 720 


Leu Ser Leu Ser Pro Gly 
                725     


<210>  202
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A linker sequence

<400>  202

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  203
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SERPING1 WT sp aa sequence

<400>  203

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser 
            20          


<210>  204
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP7 sp aa sequence

<400>  204

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  205
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB sp aa sequence

<400>  205

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  206
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ORM1 sp aa sequence

<400>  206

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala 
        


<210>  207
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TF sp aa sequence

<400>  207

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210>  208
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMBP sp aa sequence

<400>  208

Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala 
1               5                   10                  15      


Val Ser Ala 
            


<210>  209
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMP1 sp aa sequence

<400>  209

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala 
            20                  25              


<210>  210
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTNA2 sp aa sequence

<400>  210

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


<210>  211
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD300 sp aa sequence

<400>  211

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Gly Cys Phe 
1               5                   10                  15      


Ala 
    


<210>  212
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOTCH2 sp aa sequence

<400>  212

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala 
            20                  25  


<210>  213
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STRC sp aa sequence

<400>  213

Met Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Phe Ala 
            20      


<210>  214
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHSG sp aa sequence

<400>  214

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser 
        


<210>  215
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYN1 sp aa sequence

<400>  215

Met Lys Phe Ala Leu Val Ala Ala Leu Ala Leu Leu Leu Phe Leu Trp 
1               5                   10                  15      


Ser Ser Cys Arg Ala 
            20      


<210>  216
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYN2 sp aa sequence

<400>  216

Met Lys Phe Ala Leu Val Ala Ala Leu Ala Leu Leu Leu Phe Leu Trp 
1               5                   10                  15      


Gly Cys His Ser 
            20  


<210>  217
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYN3 sp aa sequence

<400>  217

Met Lys Trp Val Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Phe Leu 
1               5                   10                  15      


Trp Gly Cys His Ser 
            20      


<210>  218
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYN4 sp aa sequence

<400>  218

Met Lys Trp Val Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Phe Leu 
1               5                   10                  15      


Trp Ser Ser Cys Arg Ala 
            20          


<210>  219
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(WT) aa sequence

<400>  219

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  220
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(Ishino) aa sequence

<400>  220

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Asn 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Asn Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  221
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(Ying) aa sequence

<400>  221

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Lys Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Val Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser Tyr Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  222
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(YTE) aa sequence

<400>  222

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  223
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(LS) aa sequence

<400>  223

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        195                 200                 205             


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  224
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc(IFL) aa sequence

<400>  224

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Ile Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Phe Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  225
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ApoE Enhancer V18

<400>  225
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc acttgacccc ttggaatttt ggtggagagg agcagaggtt gtcctggtgt      300

ggtttaggta gtgtgagagg g                                                321


   
<210>  226
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VP1

<400>  226

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  227
<211>  11301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21(Intron 2-3)_BGH228 - 
       SINES_LINES -CpG

<400>  227
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggta tgtggtccct tgtgggatgg gggactgggg     1500

tggagagggg aggcaggatg gtggggggtg cctggggtgg ctgaggatta acccttcagg     1560

ctggggggaa tgaggagagc tcctcttggg atcattgagt gtgatccttg cacaggcact     1620

ggtagatgta tcaaagcaag agtttgttgt agaaaagagc tgtggggagg agaggtttgg     1680

ctgctgtgac acagagggtg gtcccaggct agggcctgtg aagacaggga agaatggtag     1740

caaacatagg tgggtctggg tgggggtcaa tagcagtgag aggtcccagt ggtctgggag     1800

gtcatggact agaaataagg ctaagaagtg caggatccca ggagaaaggt aggtaggggt     1860

gtgtgtatgt gggtgtgtgt gtgtgtgcac ccccaagttg gtatcacata ctcagcctgc     1920

ctatactact tctctctccc tcccttcctg cctcccttct ttcctccttc cctttcttcc     1980

ttcccttcct aatgtgtact gttttttact gttctaaatc aaggagcaca agttcaaatg     2040

tctgtactag ccaagcaagt gagtcaaaca ggtagatatt tacaggaaat tgcaagaaca     2100

tagataaatg acaacactca gcttcactgt ttggaaaaca acttcctaca gggcagtaat     2160

tggtcagaga ttacagagtc cctgactatc cctcatcttc tgcagagcac attcctgtgc     2220

acccccaccc tcaccctgta ttgccccttc tctgaggaat tagtggtggt ggttctaaga     2280

cagattgctc atctgcccca ctgtcagaaa ttactctctt gtacaggaca ttttccacat     2340

ccacaccttc tcttcctgct ttgagtattt tagaggactg tgcctgctag taagaaaaaa     2400

atgaaactca gtttcttgaa ccacaggaca gggccagctc taaccccaat gctacttcta     2460

gctcctctca ggaccctgag agcctgcagg acagggggga gggcaaggtg gccaccactg     2520

tgatctctaa gatgctgttt gtggagccca tcctggaggt gagcagcctg cccaccacca     2580

acagcaccac caactctgcc actaagatca ctgccaacac cactgatgag cccaccaccc     2640

agcccactac tgagcccacc acccagccta ctatccagcc cacccagccc actacccagc     2700

tgcccactga cagccctacc cagcccacca ctggcagctt ctgccctggg cctgtgaccc     2760

tgtgctctga cctggagagc cattctactg aggctgtgct gggggatgcc ctggtggact     2820

tctctctgaa gctgtaccat gctttctctg ccatgaagaa ggtggagact aacatggctt     2880

ttagcccctt cagcattgct agcctgctga cccaggtgct gctgggggct ggggagaaca     2940

ctaagaccaa cctggaatct atcctgagct accccaagga cttcacctgt gtgcaccagg     3000

ccctgaaggg cttcaccacc aagggggtga cctctgtgag ccagatcttc cacagccctg     3060

acctggccat cagggatact tttgtgaatg ccagcagaac cctgtactct tctagcccca     3120

gggtgctgag caataattct gatgctaacc tggagctgat caatacctgg gtggctaaga     3180

ataccaacaa caagattagc aggctgctgg actctctgcc ttctgatacc aggctggtgc     3240

tgctgaatgc catttacctg tctgccaagt ggaagaccac ttttgaccct aagaagacta     3300

ggatggagcc tttccacttc aagaactctg tcattaaggt gcccatgatg aacagcaaga     3360

agtatcctgt ggcccacttt attgaccaga ctctgaaggc caaggtgggc cagctgcagc     3420

tgagccataa cctgagcctg gtgatcctgg tgccccagaa cctgaagcat aggctggagg     3480

acatggagca ggctctgagc ccctctgtgt tcaaggctat tatggagaag ctggagatga     3540

gcaagttcca gcccactctg ctgaccctgc ccagaatcaa ggtgaccacc tctcaggaca     3600

tgctgagcat catggaaaag ctggagttct ttgacttttc ttatgacctg aatctgtgtg     3660

gcctgactga ggatcctgat ctgcaggtgt ctgccatgca gcaccagact gtgctggagc     3720

tgactgagac tggggtggag gctgctgctg cttctgccat ctctgtggcc aggaccctgc     3780

tggtgtttga ggtgcagcag cccttcctgt ttgtgctgtg ggaccagcag cacaagtttc     3840

ctgtgttcat gggcagggtg tatgacccca gagcctgaca tctagagctg aattcctgca     3900

gccaggggga tcagcctcta ctgtgccttc tagttgccag ccatctgttg tttgcccctc     3960

ccccttgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     4020

ggaaattgca tcacattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     4080

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cagtgggctc     4140

tatggcttct gaggcagaaa gaaccagctg gggctcgaga tccactaggg ccgcaggaac     4200

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     4260

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     4320

gcagctgcct gcaggggccc atgggcagat gcaccacctg tctcagtgca aagccctgcc     4380

taagtaggct ggtcataaga ccatgtgtct ggctgtaact ccaattgatt gtcagcatca     4440

ataaaacttg gccaacactg ttatatactg gtattgatag ttacaactga acatatttgt     4500

ttaagcaatt ggaattaaga attcacatgc aatgatatca gggtccttct cctctggtta     4560

gtgtattggg gggaaattgg acatctctca gctcagtagg ctagttaggc caggatggat     4620

gacatccaca gcccctgggc agagagatta tgatgtagct agtctgactc ctgacaaaga     4680

cttgcttcct ggagcttcta ctactttctg gtggatggct aagaaatatg gttgtgttct     4740

tttaagtctg aagagcatta tttttgccaa cccctgacca aacatccttg ccaaggaaaa     4800

ggcctaaaat atatttgcat ttaaagatat tacaaactac ttggttttgg aatgtttggc     4860

ctttcaggat catagctatc aaaatattag ctatttgggg tatgagatgt ctgcttggtc     4920

aaggacaagt tcttaaagac atcatgttgg ggaataatgg ggaaaatggg aaggcttatg     4980

ctctgagtaa gacatctgag ttatcatctg tcaaacattt ttgttagtca tagtctaatg     5040

ggagcctgtt ttccctcttt aatatacatt cacatctgaa tttatgctct tcattgacaa     5100

tgccagccca gaacaacagc tcttaccctt tggttttctt cctaaccttt aactccaatg     5160

taaccattac ctgccatttc agtaaaacca ttattctccc tacttaccca cccaagttgt     5220

acaataaaga gtgtttgctc tcactcatat acaaagcaaa ttcatttgtt tgtgatgtac     5280

agcttgctat gcccacagat gtggtttgcc tagtcctttg ctctaggtca tttgactggg     5340

aacagatggg atgctcactt tggtttttaa tggttaatct agtcattgaa atgcatttca     5400

tcaaataatc ttagaggata attgtttaaa tgtctgtcca gactagcttt gtagagccag     5460

gtgccattac acatgtcacc ttcttatttc tcttaattga atttttatca tctgagatag     5520

gaataataga gggctttttc aagtgaagat attactatag tctaaagacc ttagtgtaac     5580

atcctggccc ctaaggaaaa acaagttctg gttcatacat ataataactt tgcatgttat     5640

ctgccactga gatgtgtcct aatccaacag aaaggattga atctctgtag ctaggtgtac     5700

agggcaagag ctgtacaggg aacctttaaa gatagcttca ggccaaagct gaggaaagtg     5760

gatggagact ggggaaaatg ctaagacatt ttaaagattt tctttaggtc aaaaatagaa     5820

taagaaatag accatttccc tggacatttt ctgtaggtta atactgttga actattggta     5880

aatgcttatg ctacaactta atatgtctgc tttgtgagtt tagcattgtc tccttgtcat     5940

tccagaaatg aaatggcaaa tacatttaaa tcagaactaa aaaggggaac agggtataaa     6000

ggctcaattt agtcacatca tttccctttc tcacccaccc cctttaaacc agatgtttgc     6060

caatgcatta acaatgcaga tgtttcctga aagaaagttt agtaactcaa gcagacacct     6120

tattttcttt tcaagcagaa aagactatga gatggtggtt gtggttgttc tgggagggag     6180

aagatataaa tgatacacat tatttcaaat catttcatga cctcactgca cacttatagt     6240

tattgtacct gttgtctttt tgctgtcaag cctagctaag atcatttgga atgttcaaga     6300

tcactcatac atgcatgtgc acacatacac atgcacatat gttcactccc tatttcatcc     6360

acatgaacta agattactga tgtgtacaga ttcaaagcac ttttattctt ttccaaaggc     6420

aagaagctga gctactttcc agaatagttg tgaaagaccc tgtcatactt ctgcattgtt     6480

tcctccacac cacctccatc cagttcctta tgaatggtta ctggttttca aaaatatgag     6540

ataaattgag tgtataaaag tcatttttag acaaaatgaa acaggaaatg aaagaaacca     6600

gaatctctcc tcatttgtgg atgggccagc tccaccatgt catggttaat ctgcagggag     6660

gaaatactag atttgattgc agatcagact gcagcaaacc tgctgtgact aaggcatcaa     6720

gagaaagcaa gcaacagctg gggcttcagt ggtgaaaaca ttatatatct agctttgaaa     6780

tatgaaatac tgtttagcag tgtcacctag aaaagagtgt ttcaaaatgc tgatgcttca     6840

taagaacctt tctcttcaga gttgtttctt ttatctttca aattagccag ggtgggaaat     6900

aaagtgatca cttggtgaag aaatctcaca aagaagaaca tagagagttc actttcatct     6960

ggagtaatga acagattgaa caaactagaa atggttagtc tgttaaagaa aaggtgtagg     7020

tgagctgttt gcaagagcca caagggaaag gggaagacaa cttctttgtg gacttaaggg     7080

tgaaagttgc aagcaggcaa gaccattctg acctccatta agaaagccct ttccaaccaa     7140

caaccactgg gttggttact caggttgggc agcattggga gcaaatgttg attgaacaaa     7200

tgtttgtcag aattgttgac ttaaagagct gttctgtcac tggggacagc agcagctaga     7260

tagccccatt cagggagagg gcatttgttc acctggccag agatcagagc aggctaaggg     7320

actgctggga tcctgtccag ctttgagacc ctacagagcc atgttcacct agcaggtatc     7380

ccttctgagg tcactctcat ttcttacctt attccagggc tttcacctca gcttgccagg     7440

ctggagccaa gggccaaggc agcctcacct tgttggctat ggtagcttcc caggagcccc     7500

ctatggttca ggaacagctc tgcctgcccc atcctgtttg ctacctccta aagccaaagg     7560

cactggtggg ccaggccagc ttctaaagtc acacaaggtt agaaggttcc tgacaggaag     7620

ggcttgaggc caatggaagg aggtacttca gtttccctcc agatgcccag tgatgggctc     7680

agagctcctt gagaacttgg gaaaggaagc agggtctctg aagaaatact tcaggagtag     7740

aaagaggaag ctagagggtt aaatgcacta cacaggaaca gaaatgagtt tttcttagag     7800

ttagtatatg tcttagaggt gtagtaaact aaaacaagtc ttgaattgca tacagccact     7860

tagggaagaa atgaaaacct ttgaatatta gtgaaaaaag ggaaactgca acccctgtat     7920

tactagatag ctttcatcaa cagctcaaaa cagacagatt tttataggtt tactgtgtgc     7980

actttaatac aagggcagtg gttcagaact tagtcaggtc ctgaaaagga tttaccaaat     8040

gttgagtgtg ccctctagtg ttcacacttc ccagctttct tcctataaag gtggatcaag     8100

gcacttgctt acaactggaa ctgaaatcct ccaagtggaa ctagacattg agatggagaa     8160

aatattcatt gtccactgta attatgcaag gaatatccag ttgagataat ggacttgcct     8220

cttatctaat aatacccagg ctcaatgggt cactgctttg tccactttgc ccaaaattca     8280

agcacagcta agttgatatt ttaggacaaa ggcagcttac tatccagcca gaggggagta     8340

gaatatggtt aagagagagt ggaaagaatg aatgagccct gctattcctc actgcctgga     8400

tggctataag cacagccctt atggaggcct taggtcttgc ttcataatat tccagtttga     8460

aaagggtttg aaaagacctc ctagaaaaat cagtagtttt tctcttttga gtaacatgta     8520

gcaaaaaaaa tttcatcatg taggtacagg gaacacccta ataactatta atctcaagga     8580

gtcaagccag tgtgtttcct aatgtatctg ctgtatcccc atgaagcaaa ttttgccatc     8640

agagaaactg actcatgggg aaaaaatcca aggacctcaa atcaccaaaa gaagccattc     8700

ctcagatttg cctaagctta agcttccctg tctctcattg tgtgttgctt tcaatgcagt     8760

tacataaatg gcttttttgt ttatgcacca aaaacactaa ttcatctgca aagctatagg     8820

tcaaagcaac catagtatgc accctgctag ctggcgcatt aagcgcggcg ggtgtggtgg     8880

ttacgcgcag cgtgaccgct acacttgcca gcgccttagc gcccgctcct ttcgctttct     8940

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc     9000

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gatttgggtg     9060

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt     9120

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac tctatctcgg     9180

gctattcttt tgatttagac ctgcaggcat gcaagcttgg cactggccgt cgttttacaa     9240

cgtcgtgact gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct     9300

ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc     9360

agcctgaatg gcgaatgcga tttattcaac aaagccgccg tcccgtcaag tcagcgtaat     9420

gctctgccag tgttacaacc aattaaccaa ttctgattag aaaaactcat cgagcatcaa     9480

atgaaactgc aatttattca tatcaggatt atcaatacca tatttttgaa aaagccgttt     9540

ctgtaatgaa ggagaaaact caccgaggca gttccatagg atggcaagat cctggtatcg     9600

gtctgcgatt ccgactcgtc caacatcaat acaacctatt aatttcccct cgtcaaaaat     9660

aaggttatca agtgagaaat caccatgagt gacgactgaa tccggtgaga atggcaaaag     9720

cttatgcatt tctttccaga cttgttcaac aggccagcca ttacgctcgt catcaaaatc     9780

actcgcatca accaaaccgt tattcattcg tgattgcgcc tgagcgagac gaaatacgcg     9840

atcgctgtta aaaggacaat tacaaacagg aatcgaatgc aaccggcgca ggaacactgc     9900

cagcgcatca acaatatttt cacctgaatc aggatattct tctaatacct ggaatgctgt     9960

tttcccgggg atcgcagtgg tgagtaacca tgcatcatca ggagtacgga taaaatgctt    10020

gatggtcgga agaggcataa attccgtcag ccagtttagt ctgaccatct catctgtaac    10080

atcattggca acgctacctt tgccatgttt cagaaacaac tctggcgcat cgggcttccc    10140

atacaatcga tagattgtcg cacctgattg cccgacatta tcgcgagccc atttataccc    10200

atataaatca gcatccatgt tggaatttaa tcgcggcttc gagcaagacg tttcccgttg    10260

aatatggctc ataacacccc ttgtattact gtttatgtaa gcagacagtt ttattgttca    10320

tgatgatata tttttatctt gtgcaatgta acatcagaga ttttgagaca caacgtggct    10380

ttgttgaata aatcgaactt ttgctgagtt gaaggatcag atcacgcatc ttcccgacaa    10440

cgcagaccgt tccgtggcaa agcaaaagtt caaaatcacc aactggtcca cctacaacaa    10500

agctctcatc aaccgtggct ccctcacttt ctggctggat gatggggcga ttcaggcctg    10560

gtatgagtca gcaacacctt cttcacgagg cagacctctc gacggagttc cactgagcgt    10620

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct    10680

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc    10740

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc    10800

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc    10860

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg    10920

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt    10980

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg    11040

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg    11100

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt    11160

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag    11220

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt    11280

gctggccttt tgctcacatg t                                              11301


<210>  228
<211>  10997
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1_SERPING1co21(Intron 3-4)_BGH228 - 
       SINES_LINES-CpG

<400>  228
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcttgaga acttcagggt gagtctatgg gacccttgat      900

gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggac agggccagct ctaaccccaa tgctacttct     1500

agctcctctc aggaccctga gagcctgcag gacagggggg agggcaaggt ggccaccact     1560

gtgatctcta agatgctgtt tgtggagccc atcctggagg tgagcagcct gcccaccacc     1620

aacagcacca ccaactctgc cactaagatc actgccaaca ccactgatga gcccaccacc     1680

cagcccacta ctgagcccac cacccagcct actatccagc ccacccagcc cactacccag     1740

ctgcccactg acagccctac ccagcccacc actggcagct tctgccctgg gcctgtgacc     1800

ctgtgctctg acctggagag ccattctact gaggctgtgc tgggggatgc cctggtggac     1860

ttctctctga agctgtacca tgctttctct gccatgaaga aggtggagac taacatggct     1920

tttagcccct tcagcattgc tagcctgctg acccaggtgc tgctgggtaa gaccctgctt     1980

gaattctctc caggtcattt gttggacact cccataagag tcaccaatcc agacacttac     2040

aaagccatgc ctctgggaag aagctgtaaa aatgggctat tatatattgg gggtggggta     2100

gagggatgta tcttttcatt cttgaacatt ccatcatttc acagtgatgt aataggcacc     2160

attgcttgta aaactctgtg actatacaag aacatataaa ataaggtccc agccactaac     2220

catgtttcat ggcaaggaga ggtgataaga aagatgaaat tattatcaga agaagcagaa     2280

agccagcagc ctagtgtctg acttagtggg aggtcaaaaa aatgtaaatc ctctgccatc     2340

ttgagggatt actgtcaagt cccatttggt aattacccta ggaatggcac aaacaaatta     2400

ctacaagcag tggggacaga gctattactc cccagagaga attctaaaaa ggctacagaa     2460

tctttcttga gagattgaga gaacacttcc agctcagatg atctgtgatc ccctccaaag     2520

cagggaatac cctccattcc agcctggtcc ccaaccctca ttcccaagga aggcccccca     2580

ctcatcctgc aagtatcttt catctctgcc ctttgttgca ggggctgggg agaacactaa     2640

gaccaacctg gaatctatcc tgagctaccc caaggacttc acctgtgtgc accaggccct     2700

gaagggcttc accaccaagg gggtgacctc tgtgagccag atcttccaca gccctgacct     2760

ggccatcagg gatacttttg tgaatgccag cagaaccctg tactcttcta gccccagggt     2820

gctgagcaat aattctgatg ctaacctgga gctgatcaat acctgggtgg ctaagaatac     2880

caacaacaag attagcaggc tgctggactc tctgccttct gataccaggc tggtgctgct     2940

gaatgccatt tacctgtctg ccaagtggaa gaccactttt gaccctaaga agactaggat     3000

ggagcctttc cacttcaaga actctgtcat taaggtgccc atgatgaaca gcaagaagta     3060

tcctgtggcc cactttattg accagactct gaaggccaag gtgggccagc tgcagctgag     3120

ccataacctg agcctggtga tcctggtgcc ccagaacctg aagcataggc tggaggacat     3180

ggagcaggct ctgagcccct ctgtgttcaa ggctattatg gagaagctgg agatgagcaa     3240

gttccagccc actctgctga ccctgcccag aatcaaggtg accacctctc aggacatgct     3300

gagcatcatg gaaaagctgg agttctttga cttttcttat gacctgaatc tgtgtggcct     3360

gactgaggat cctgatctgc aggtgtctgc catgcagcac cagactgtgc tggagctgac     3420

tgagactggg gtggaggctg ctgctgcttc tgccatctct gtggccagga ccctgctggt     3480

gtttgaggtg cagcagccct tcctgtttgt gctgtgggac cagcagcaca agtttcctgt     3540

gttcatgggc agggtgtatg accccagagc ctgacatcta gagctgaatt cctgcagcca     3600

gggggatcag cctctactgt gccttctagt tgccagccat ctgttgtttg cccctccccc     3660

ttgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     3720

attgcatcac attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     3780

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcagt gggctctatg     3840

gcttctgagg cagaaagaac cagctggggc tcgagatcca ctagggccgc aggaacccct     3900

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     3960

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     4020

ctgcctgcag gggcccatgg gcagatgcac cacctgtctc agtgcaaagc cctgcctaag     4080

taggctggtc ataagaccat gtgtctggct gtaactccaa ttgattgtca gcatcaataa     4140

aacttggcca acactgttat atactggtat tgatagttac aactgaacat atttgtttaa     4200

gcaattggaa ttaagaattc acatgcaatg atatcagggt ccttctcctc tggttagtgt     4260

attgggggga aattggacat ctctcagctc agtaggctag ttaggccagg atggatgaca     4320

tccacagccc ctgggcagag agattatgat gtagctagtc tgactcctga caaagacttg     4380

cttcctggag cttctactac tttctggtgg atggctaaga aatatggttg tgttctttta     4440

agtctgaaga gcattatttt tgccaacccc tgaccaaaca tccttgccaa ggaaaaggcc     4500

taaaatatat ttgcatttaa agatattaca aactacttgg ttttggaatg tttggccttt     4560

caggatcata gctatcaaaa tattagctat ttggggtatg agatgtctgc ttggtcaagg     4620

acaagttctt aaagacatca tgttggggaa taatggggaa aatgggaagg cttatgctct     4680

gagtaagaca tctgagttat catctgtcaa acatttttgt tagtcatagt ctaatgggag     4740

cctgttttcc ctctttaata tacattcaca tctgaattta tgctcttcat tgacaatgcc     4800

agcccagaac aacagctctt accctttggt tttcttccta acctttaact ccaatgtaac     4860

cattacctgc catttcagta aaaccattat tctccctact tacccaccca agttgtacaa     4920

taaagagtgt ttgctctcac tcatatacaa agcaaattca tttgtttgtg atgtacagct     4980

tgctatgccc acagatgtgg tttgcctagt cctttgctct aggtcatttg actgggaaca     5040

gatgggatgc tcactttggt ttttaatggt taatctagtc attgaaatgc atttcatcaa     5100

ataatcttag aggataattg tttaaatgtc tgtccagact agctttgtag agccaggtgc     5160

cattacacat gtcaccttct tatttctctt aattgaattt ttatcatctg agataggaat     5220

aatagagggc tttttcaagt gaagatatta ctatagtcta aagaccttag tgtaacatcc     5280

tggcccctaa ggaaaaacaa gttctggttc atacatataa taactttgca tgttatctgc     5340

cactgagatg tgtcctaatc caacagaaag gattgaatct ctgtagctag gtgtacaggg     5400

caagagctgt acagggaacc tttaaagata gcttcaggcc aaagctgagg aaagtggatg     5460

gagactgggg aaaatgctaa gacattttaa agattttctt taggtcaaaa atagaataag     5520

aaatagacca tttccctgga cattttctgt aggttaatac tgttgaacta ttggtaaatg     5580

cttatgctac aacttaatat gtctgctttg tgagtttagc attgtctcct tgtcattcca     5640

gaaatgaaat ggcaaataca tttaaatcag aactaaaaag gggaacaggg tataaaggct     5700

caatttagtc acatcatttc cctttctcac ccaccccctt taaaccagat gtttgccaat     5760

gcattaacaa tgcagatgtt tcctgaaaga aagtttagta actcaagcag acaccttatt     5820

ttcttttcaa gcagaaaaga ctatgagatg gtggttgtgg ttgttctggg agggagaaga     5880

tataaatgat acacattatt tcaaatcatt tcatgacctc actgcacact tatagttatt     5940

gtacctgttg tctttttgct gtcaagccta gctaagatca tttggaatgt tcaagatcac     6000

tcatacatgc atgtgcacac atacacatgc acatatgttc actccctatt tcatccacat     6060

gaactaagat tactgatgtg tacagattca aagcactttt attcttttcc aaaggcaaga     6120

agctgagcta ctttccagaa tagttgtgaa agaccctgtc atacttctgc attgtttcct     6180

ccacaccacc tccatccagt tccttatgaa tggttactgg ttttcaaaaa tatgagataa     6240

attgagtgta taaaagtcat ttttagacaa aatgaaacag gaaatgaaag aaaccagaat     6300

ctctcctcat ttgtggatgg gccagctcca ccatgtcatg gttaatctgc agggaggaaa     6360

tactagattt gattgcagat cagactgcag caaacctgct gtgactaagg catcaagaga     6420

aagcaagcaa cagctggggc ttcagtggtg aaaacattat atatctagct ttgaaatatg     6480

aaatactgtt tagcagtgtc acctagaaaa gagtgtttca aaatgctgat gcttcataag     6540

aacctttctc ttcagagttg tttcttttat ctttcaaatt agccagggtg ggaaataaag     6600

tgatcacttg gtgaagaaat ctcacaaaga agaacataga gagttcactt tcatctggag     6660

taatgaacag attgaacaaa ctagaaatgg ttagtctgtt aaagaaaagg tgtaggtgag     6720

ctgtttgcaa gagccacaag ggaaagggga agacaacttc tttgtggact taagggtgaa     6780

agttgcaagc aggcaagacc attctgacct ccattaagaa agccctttcc aaccaacaac     6840

cactgggttg gttactcagg ttgggcagca ttgggagcaa atgttgattg aacaaatgtt     6900

tgtcagaatt gttgacttaa agagctgttc tgtcactggg gacagcagca gctagatagc     6960

cccattcagg gagagggcat ttgttcacct ggccagagat cagagcaggc taagggactg     7020

ctgggatcct gtccagcttt gagaccctac agagccatgt tcacctagca ggtatccctt     7080

ctgaggtcac tctcatttct taccttattc cagggctttc acctcagctt gccaggctgg     7140

agccaagggc caaggcagcc tcaccttgtt ggctatggta gcttcccagg agccccctat     7200

ggttcaggaa cagctctgcc tgccccatcc tgtttgctac ctcctaaagc caaaggcact     7260

ggtgggccag gccagcttct aaagtcacac aaggttagaa ggttcctgac aggaagggct     7320

tgaggccaat ggaaggaggt acttcagttt ccctccagat gcccagtgat gggctcagag     7380

ctccttgaga acttgggaaa ggaagcaggg tctctgaaga aatacttcag gagtagaaag     7440

aggaagctag agggttaaat gcactacaca ggaacagaaa tgagtttttc ttagagttag     7500

tatatgtctt agaggtgtag taaactaaaa caagtcttga attgcataca gccacttagg     7560

gaagaaatga aaacctttga atattagtga aaaaagggaa actgcaaccc ctgtattact     7620

agatagcttt catcaacagc tcaaaacaga cagattttta taggtttact gtgtgcactt     7680

taatacaagg gcagtggttc agaacttagt caggtcctga aaaggattta ccaaatgttg     7740

agtgtgccct ctagtgttca cacttcccag ctttcttcct ataaaggtgg atcaaggcac     7800

ttgcttacaa ctggaactga aatcctccaa gtggaactag acattgagat ggagaaaata     7860

ttcattgtcc actgtaatta tgcaaggaat atccagttga gataatggac ttgcctctta     7920

tctaataata cccaggctca atgggtcact gctttgtcca ctttgcccaa aattcaagca     7980

cagctaagtt gatattttag gacaaaggca gcttactatc cagccagagg ggagtagaat     8040

atggttaaga gagagtggaa agaatgaatg agccctgcta ttcctcactg cctggatggc     8100

tataagcaca gcccttatgg aggccttagg tcttgcttca taatattcca gtttgaaaag     8160

ggtttgaaaa gacctcctag aaaaatcagt agtttttctc ttttgagtaa catgtagcaa     8220

aaaaaatttc atcatgtagg tacagggaac accctaataa ctattaatct caaggagtca     8280

agccagtgtg tttcctaatg tatctgctgt atccccatga agcaaatttt gccatcagag     8340

aaactgactc atggggaaaa aatccaagga cctcaaatca ccaaaagaag ccattcctca     8400

gatttgccta agcttaagct tccctgtctc tcattgtgtg ttgctttcaa tgcagttaca     8460

taaatggctt ttttgtttat gcaccaaaaa cactaattca tctgcaaagc tataggtcaa     8520

agcaaccata gtatgcaccc tgctagctgg cgcattaagc gcggcgggtg tggtggttac     8580

gcgcagcgtg accgctacac ttgccagcgc cttagcgccc gctcctttcg ctttcttccc     8640

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt     8700

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt tgggtgatgg     8760

ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac     8820

gttctttaat agtggactct tgttccaaac tggaacaaca ctcaactcta tctcgggcta     8880

ttcttttgat ttagacctgc aggcatgcaa gcttggcact ggccgtcgtt ttacaacgtc     8940

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     9000

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     9060

tgaatggcga atgcgattta ttcaacaaag ccgccgtccc gtcaagtcag cgtaatgctc     9120

tgccagtgtt acaaccaatt aaccaattct gattagaaaa actcatcgag catcaaatga     9180

aactgcaatt tattcatatc aggattatca ataccatatt tttgaaaaag ccgtttctgt     9240

aatgaaggag aaaactcacc gaggcagttc cataggatgg caagatcctg gtatcggtct     9300

gcgattccga ctcgtccaac atcaatacaa cctattaatt tcccctcgtc aaaaataagg     9360

ttatcaagtg agaaatcacc atgagtgacg actgaatccg gtgagaatgg caaaagctta     9420

tgcatttctt tccagacttg ttcaacaggc cagccattac gctcgtcatc aaaatcactc     9480

gcatcaacca aaccgttatt cattcgtgat tgcgcctgag cgagacgaaa tacgcgatcg     9540

ctgttaaaag gacaattaca aacaggaatc gaatgcaacc ggcgcaggaa cactgccagc     9600

gcatcaacaa tattttcacc tgaatcagga tattcttcta atacctggaa tgctgttttc     9660

ccggggatcg cagtggtgag taaccatgca tcatcaggag tacggataaa atgcttgatg     9720

gtcggaagag gcataaattc cgtcagccag tttagtctga ccatctcatc tgtaacatca     9780

ttggcaacgc tacctttgcc atgtttcaga aacaactctg gcgcatcggg cttcccatac     9840

aatcgataga ttgtcgcacc tgattgcccg acattatcgc gagcccattt atacccatat     9900

aaatcagcat ccatgttgga atttaatcgc ggcttcgagc aagacgtttc ccgttgaata     9960

tggctcataa caccccttgt attactgttt atgtaagcag acagttttat tgttcatgat    10020

gatatatttt tatcttgtgc aatgtaacat cagagatttt gagacacaac gtggctttgt    10080

tgaataaatc gaacttttgc tgagttgaag gatcagatca cgcatcttcc cgacaacgca    10140

gaccgttccg tggcaaagca aaagttcaaa atcaccaact ggtccaccta caacaaagct    10200

ctcatcaacc gtggctccct cactttctgg ctggatgatg gggcgattca ggcctggtat    10260

gagtcagcaa caccttcttc acgaggcaga cctctcgacg gagttccact gagcgtcaga    10320

ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg    10380

cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc    10440

aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct    10500

agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc    10560

tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt    10620

ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg    10680

cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct    10740

atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag    10800

ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag    10860

tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg    10920

gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg    10980

gccttttgct cacatgt                                                   10997


<210>  229
<211>  10343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSwap_ApoE_hAAT_HBB2m1(-ATG)_SERPING1coI21(-RIDD)_BGH228

<400>  229
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc       60

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg      120

cggcctagta ctaggctcag aggcacacag gagtttctgg gctcaccctg cccccttcca      180

acccctcagt tcccatcctc cagcagctgt ttgtgtgctg cctctgaagt ccacactgaa      240

caaacttcag cctactcatg tccctaaaat gggcaaacat tgcaagcagc aaacagcaaa      300

cacacagccc tccctgcctg ctgaccttgg agctggggca gaggtcagag acctctctgg      360

gcccatgcca cctccaacat ccactcgacc ccttggaatt tcggtggaga ggagcagagg      420

ttgtcctggc gtggtttagg tagtgtgaga ggggtacccg gggatcttgc taccagtgga      480

acagccacta aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag      540

actgtctgac tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca      600

ggtacaatga ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc      660

cgggcagcgt aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct      720

ccgataactg gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg      780

atccactgct taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca      840

ctgacctggg acagtgaata gatcctgaga acttcagggt gagtctttgg gacccttgtt      900

gttttctttc cccttctttt ctttggttaa gttcttgtca taggaagggg agaagtaaca      960

gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aattgctttc     1020

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1080

cagggcaata ttgatacatt gtatcttgcc tctttgcacc attctaaaga ataacagtga     1140

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1200

gtaactgttg taagaggttt catattgcta atagcagcta caatccagct accattctgc     1260

ttttattttc tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1320

aatcttgttc atacctctta tcttcctccc acagctcctg ggcaacctgc tggtctctct     1380

gctggcccat cactttggca aagcactagt gccaccatgg cctctaggct gactctgctg     1440

actctgctgc tcctgctgct ggctggggac agggccagct ctaaccccaa tgctacttct     1500

agctcctctc aggaccctga gagccttcag gacagggggg agggcaaggt ggccaccact     1560

gtgatctcta agatgctgtt tgtggagccc atcctggagg tgagcagcct gcccaccacc     1620

aacagcacca ccaactctgc cactaagatc actgccaaca ccactgatga gcccaccacc     1680

cagcccacta ctgagcccac cacccagcct actatccagc ccacccagcc cactacccag     1740

ctgcccactg acagccctac ccagcccacc actggcagct tctgccctgg gcctgtgacc     1800

ctgtgctctg acctggagag ccattctact gaggctgtgc tgggggatgc cctggtggac     1860

ttctctctga agctgtacca tgctttctct gccatgaaga aggtggagac taacatggct     1920

tttagcccct tcagcattgc tagcctgctg acccaggtgc tgctgggggc tggggagaac     1980

actaagacca acctggaatc tatcctgagc taccccaagg acttcacctg tgtgcaccag     2040

gccctgaagg gcttcaccac caagggggtg acctctgtga gccagatctt ccacagccct     2100

gacctggcca tcagggatac ttttgtgaat gccagcagaa ccctgtactc ttctagcccc     2160

agggtgctga gcaataattc tgatgctaac ctggagctga tcaatacctg ggtggctaag     2220

aataccaaca acaagattag caggctgctg gactctctgc cttctgatac caggctggtg     2280

ctgctgaatg ccatttacct gtctgccaag tggaagacca cttttgaccc taagaagact     2340

aggatggagc ctttccactt caagaactct gtcattaagg tgcccatgat gaacagcaag     2400

aagtatcctg tggcccactt tattgaccag actctgaagg ccaaggtggg ccagcttcag     2460

ctgagccata acctgagcct ggtgatcctg gtgccccaga acctgaagca taggctggag     2520

gacatggagc aggctctgag cccctctgtg ttcaaggcta ttatggagaa gctggagatg     2580

agcaagttcc agcccactct gctgaccctg cccagaatca aggtgaccac ctctcaggac     2640

atgctgagca tcatggaaaa gctggagttc tttgactttt cttatgacct gaatctgtgt     2700

ggcctgactg aggatcctga tcttcaggtg tctgccatgc agcaccagac tgtgctggag     2760

ctgactgaga ctggggtgga ggctgctgct gcttctgcca tctctgtggc caggaccctg     2820

ctggtgtttg aggtgcagca gcccttcctg tttgtgctgt gggaccagca gcacaagttt     2880

cctgtgttca tgggcagggt gtatgacccc agagcctgaa gatctagagc tgaattcctt     2940

cagccagggg gatcagcctc tactgtgcct tctagttgcc agccatctgt tgtttgcccc     3000

tcccccttgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     3060

gaggaaattg catcacattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     3120

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcagtgggc     3180

tctatggctt ctgaggcaga aagaaccagc tggggctcga gatccactag ggccgcagga     3240

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg     3300

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc     3360

gcgcagctgc ctgcaggggc ccatgggcag atgcaccacc tgtctcagtg caaagccctg     3420

cctaagtagg ctggtcataa gaccatgtgt ctggctgtaa ctccaattga ttgtcagcat     3480

caataaaact tggccaacac tgttatatac tggtattgat agttacaact gaacatattt     3540

gtttaagcaa ttggaattaa gaattcacat gcaatgatat cagggtcctt ctcctctggt     3600

tagtgtattg gggggaaatt ggacatctct cagctcagta ggctagttag gccaggatgg     3660

atgacatcca cagcccctgg gcagagagat tatgatgtag ctagtctgac tcctgacaaa     3720

gacttgcttc ctggagcttc tactactttc tggtggatgg ctaagaaata tggttgtgtt     3780

cttttaagtc tgaagagcat tatttttgcc aacccctgac caaacatcct tgccaaggaa     3840

aaggcctaaa atatatttgc atttaaagat attacaaact acttggtttt ggaatgtttg     3900

gcctttcagg atcatagcta tcaaaatatt agctatttgg ggtatgagat gtctgcttgg     3960

tcaaggacaa gttcttaaag acatcatgtt ggggaataat ggggaaaatg ggaaggctta     4020

tgctctgagt aagacatctg agttatcatc tgtcaaacat ttttgttagt catagtctaa     4080

tgggagcctg ttttccctct ttaatataca ttcacatctg aatttatgct cttcattgac     4140

aatgccagcc cagaacaaca gctcttaccc tttggttttc ttcctaacct ttaactccaa     4200

tgtaaccatt acctgccatt tcagtaaaac cattattctc cctacttacc cacccaagtt     4260

gtacaataaa gagtgtttgc tctcactcat atacaaagca aattcatttg tttgtgatgt     4320

acagcttgct atgcccacag atgtggtttg cctagtcctt tgctctaggt catttgactg     4380

ggaacagatg ggatgctcac tttggttttt aatggttaat ctagtcattg aaatgcattt     4440

catcaaataa tcttagagga taattgttta aatgtctgtc cagactagct ttgtagagcc     4500

aggtgccatt acacatgtca ccttcttatt tctcttaatt gaatttttat catctgagat     4560

aggaataata gagggctttt tcaagtgaag atattactat agtctaaaga ccttagtgta     4620

acatcctggc ccctaaggaa aaacaagttc tggttcatac atataataac tttgcatgtt     4680

atctgccact gagatgtgtc ctaatccaac agaaaggatt gaatctctgt agctaggtgt     4740

acagggcaag agctgtacag ggaaccttta aagatagctt caggccaaag ctgaggaaag     4800

tggatggaga ctggggaaaa tgctaagaca ttttaaagat tttctttagg tcaaaaatag     4860

aataagaaat agaccatttc cctggacatt ttctgtaggt taatactgtt gaactattgg     4920

taaatgctta tgctacaact taatatgtct gctttgtgag tttagcattg tctccttgtc     4980

attccagaaa tgaaatggca aatacattta aatcagaact aaaaagggga acagggtata     5040

aaggctcaat ttagtcacat catttccctt tctcacccac cccctttaaa ccagatgttt     5100

gccaatgcat taacaatgca gatgtttcct gaaagaaagt ttagtaactc aagcagacac     5160

cttattttct tttcaagcag aaaagactat gagatggtgg ttgtggttgt tctgggaggg     5220

agaagatata aatgatacac attatttcaa atcatttcat gacctcactg cacacttata     5280

gttattgtac ctgttgtctt tttgctgtca agcctagcta agatcatttg gaatgttcaa     5340

gatcactcat acatgcatgt gcacacatac acatgcacat atgttcactc cctatttcat     5400

ccacatgaac taagattact gatgtgtaca gattcaaagc acttttattc ttttccaaag     5460

gcaagaagct gagctacttt ccagaatagt tgtgaaagac cctgtcatac ttctgcattg     5520

tttcctccac accacctcca tccagttcct tatgaatggt tactggtttt caaaaatatg     5580

agataaattg agtgtataaa agtcattttt agacaaaatg aaacaggaaa tgaaagaaac     5640

cagaatctct cctcatttgt ggatgggcca gctccaccat gtcatggtta atctgcaggg     5700

aggaaatact agatttgatt gcagatcaga ctgcagcaaa cctgctgtga ctaaggcatc     5760

aagagaaagc aagcaacagc tggggcttca gtggtgaaaa cattatatat ctagctttga     5820

aatatgaaat actgtttagc agtgtcacct agaaaagagt gtttcaaaat gctgatgctt     5880

cataagaacc tttctcttca gagttgtttc ttttatcttt caaattagcc agggtgggaa     5940

ataaagtgat cacttggtga agaaatctca caaagaagaa catagagagt tcactttcat     6000

ctggagtaat gaacagattg aacaaactag aaatggttag tctgttaaag aaaaggtgta     6060

ggtgagctgt ttgcaagagc cacaagggaa aggggaagac aacttctttg tggacttaag     6120

ggtgaaagtt gcaagcaggc aagaccattc tgacctccat taagaaagcc ctttccaacc     6180

aacaaccact gggttggtta ctcaggttgg gcagcattgg gagcaaatgt tgattgaaca     6240

aatgtttgtc agaattgttg acttaaagag ctgttctgtc actggggaca gcagcagcta     6300

gatagcccca ttcagggaga gggcatttgt tcacctggcc agagatcaga gcaggctaag     6360

ggactgctgg gatcctgtcc agctttgaga ccctacagag ccatgttcac ctagcaggta     6420

tcccttctga ggtcactctc atttcttacc ttattccagg gctttcacct cagcttgcca     6480

ggctggagcc aagggccaag gcagcctcac cttgttggct atggtagctt cccaggagcc     6540

ccctatggtt caggaacagc tctgcctgcc ccatcctgtt tgctacctcc taaagccaaa     6600

ggcactggtg ggccaggcca gcttctaaag tcacacaagg ttagaaggtt cctgacagga     6660

agggcttgag gccaatggaa ggaggtactt cagtttccct ccagatgccc agtgatgggc     6720

tcagagctcc ttgagaactt gggaaaggaa gcagggtctc tgaagaaata cttcaggagt     6780

agaaagagga agctagaggg ttaaatgcac tacacaggaa cagaaatgag tttttcttag     6840

agttagtata tgtcttagag gtgtagtaaa ctaaaacaag tcttgaattg catacagcca     6900

cttagggaag aaatgaaaac ctttgaatat tagtgaaaaa agggaaactg caacccctgt     6960

attactagat agctttcatc aacagctcaa aacagacaga tttttatagg tttactgtgt     7020

gcactttaat acaagggcag tggttcagaa cttagtcagg tcctgaaaag gatttaccaa     7080

atgttgagtg tgccctctag tgttcacact tcccagcttt cttcctataa aggtggatca     7140

aggcacttgc ttacaactgg aactgaaatc ctccaagtgg aactagacat tgagatggag     7200

aaaatattca ttgtccactg taattatgca aggaatatcc agttgagata atggacttgc     7260

ctcttatcta ataataccca ggctcaatgg gtcactgctt tgtccacttt gcccaaaatt     7320

caagcacagc taagttgata ttttaggaca aaggcagctt actatccagc cagaggggag     7380

tagaatatgg ttaagagaga gtggaaagaa tgaatgagcc ctgctattcc tcactgcctg     7440

gatggctata agcacagccc ttatggaggc cttaggtctt gcttcataat attccagttt     7500

gaaaagggtt tgaaaagacc tcctagaaaa atcagtagtt tttctctttt gagtaacatg     7560

tagcaaaaaa aatttcatca tgtaggtaca gggaacaccc taataactat taatctcaag     7620

gagtcaagcc agtgtgtttc ctaatgtatc tgctgtatcc ccatgaagca aattttgcca     7680

tcagagaaac tgactcatgg ggaaaaaatc caaggacctc aaatcaccaa aagaagccat     7740

tcctcagatt tgcctaagct taagcttccc tgtctctcat tgtgtgttgc tttcaatgca     7800

gttacataaa tggctttttt gtttatgcac caaaaacact aattcatctg caaagctata     7860

ggtcaaagca accatagtat gcaccctgct agctggcgca ttaagcgcgg cgggtgtggt     7920

ggttacgcgc agcgtgaccg ctacacttgc cagcgcctta gcgcccgctc ctttcgcttt     7980

cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct     8040

ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgatttggg     8100

tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga     8160

gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca actctatctc     8220

gggctattct tttgatttag acctgcaggc atgcaagctt ggcactggcc gtcgttttac     8280

aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc     8340

ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc     8400

gcagcctgaa tggcgaatgc gatttattca acaaagccgc cgtcccgtca agtcagcgta     8460

atgctctgcc agtgttacaa ccaattaacc aattctgatt agaaaaactc atcgagcatc     8520

aaatgaaact gcaatttatt catatcagga ttatcaatac catatttttg aaaaagccgt     8580

ttctgtaatg aaggagaaaa ctcaccgagg cagttccata ggatggcaag atcctggtat     8640

cggtctgcga ttccgactcg tccaacatca atacaaccta ttaatttccc ctcgtcaaaa     8700

ataaggttat caagtgagaa atcaccatga gtgacgactg aatccggtga gaatggcaaa     8760

agcttatgca tttctttcca gacttgttca acaggccagc cattacgctc gtcatcaaaa     8820

tcactcgcat caaccaaacc gttattcatt cgtgattgcg cctgagcgag acgaaatacg     8880

cgatcgctgt taaaaggaca attacaaaca ggaatcgaat gcaaccggcg caggaacact     8940

gccagcgcat caacaatatt ttcacctgaa tcaggatatt cttctaatac ctggaatgct     9000

gttttcccgg ggatcgcagt ggtgagtaac catgcatcat caggagtacg gataaaatgc     9060

ttgatggtcg gaagaggcat aaattccgtc agccagttta gtctgaccat ctcatctgta     9120

acatcattgg caacgctacc tttgccatgt ttcagaaaca actctggcgc atcgggcttc     9180

ccatacaatc gatagattgt cgcacctgat tgcccgacat tatcgcgagc ccatttatac     9240

ccatataaat cagcatccat gttggaattt aatcgcggct tcgagcaaga cgtttcccgt     9300

tgaatatggc tcataacacc ccttgtatta ctgtttatgt aagcagacag ttttattgtt     9360

catgatgata tatttttatc ttgtgcaatg taacatcaga gattttgaga cacaacgtgg     9420

ctttgttgaa taaatcgaac ttttgctgag ttgaaggatc agatcacgca tcttcccgac     9480

aacgcagacc gttccgtggc aaagcaaaag ttcaaaatca ccaactggtc cacctacaac     9540

aaagctctca tcaaccgtgg ctccctcact ttctggctgg atgatggggc gattcaggcc     9600

tggtatgagt cagcaacacc ttcttcacga ggcagacctc tcgacggagt tccactgagc     9660

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat     9720

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga     9780

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt     9840

tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata     9900

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac     9960

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg    10020

ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg    10080

tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag    10140

cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct    10200

ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc    10260

aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt    10320

ttgctggcct tttgctcaca tgt                                            10343


<210>  230
<211>  2462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1co21(Intron 2-3)(SINES_LINES) CpG free

<400>  230
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggtatgtggt       60

cccttgtggg atgggggact ggggtggaga ggggaggcag gatggtgggg ggtgcctggg      120

gtggctgagg attaaccctt caggctgggg ggaatgagga gagctcctct tgggatcatt      180

gagtgtgatc cttgcacagg cactggtaga tgtatcaaag caagagtttg ttgtagaaaa      240

gagctgtggg gaggagaggt ttggctgctg tgacacagag ggtggtccca ggctagggcc      300

tgtgaagaca gggaagaatg gtagcaaaca taggtgggtc tgggtggggg tcaatagcag      360

tgagaggtcc cagtggtctg ggaggtcatg gactagaaat aaggctaaga agtgcaggat      420

cccaggagaa aggtaggtag gggtgtgtgt atgtgggtgt gtgtgtgtgt gcacccccaa      480

gttggtatca catactcagc ctgcctatac tacttctctc tccctccctt cctgcctccc      540

ttctttcctc cttccctttc ttccttccct tcctaatgtg tactgttttt tactgttcta      600

aatcaaggag cacaagttca aatgtctgta ctagccaagc aagtgagtca aacaggtaga      660

tatttacagg aaattgcaag aacatagata aatgacaaca ctcagcttca ctgtttggaa      720

aacaacttcc tacagggcag taattggtca gagattacag agtccctgac tatccctcat      780

cttctgcaga gcacattcct gtgcaccccc accctcaccc tgtattgccc cttctctgag      840

gaattagtgg tggtggttct aagacagatt gctcatctgc cccactgtca gaaattactc      900

tcttgtacag gacattttcc acatccacac cttctcttcc tgctttgagt attttagagg      960

actgtgcctg ctagtaagaa aaaaatgaaa ctcagtttct tgaaccacag gacagggcca     1020

gctctaaccc caatgctact tctagctcct ctcaggaccc tgagagcctg caggacaggg     1080

gggagggcaa ggtggccacc actgtgatct ctaagatgct gtttgtggag cccatcctgg     1140

aggtgagcag cctgcccacc accaacagca ccaccaactc tgccactaag atcactgcca     1200

acaccactga tgagcccacc acccagccca ctactgagcc caccacccag cctactatcc     1260

agcccaccca gcccactacc cagctgccca ctgacagccc tacccagccc accactggca     1320

gcttctgccc tgggcctgtg accctgtgct ctgacctgga gagccattct actgaggctg     1380

tgctggggga tgccctggtg gacttctctc tgaagctgta ccatgctttc tctgccatga     1440

agaaggtgga gactaacatg gcttttagcc ccttcagcat tgctagcctg ctgacccagg     1500

tgctgctggg ggctggggag aacactaaga ccaacctgga atctatcctg agctacccca     1560

aggacttcac ctgtgtgcac caggccctga agggcttcac caccaagggg gtgacctctg     1620

tgagccagat cttccacagc cctgacctgg ccatcaggga tacttttgtg aatgccagca     1680

gaaccctgta ctcttctagc cccagggtgc tgagcaataa ttctgatgct aacctggagc     1740

tgatcaatac ctgggtggct aagaatacca acaacaagat tagcaggctg ctggactctc     1800

tgccttctga taccaggctg gtgctgctga atgccattta cctgtctgcc aagtggaaga     1860

ccacttttga ccctaagaag actaggatgg agcctttcca cttcaagaac tctgtcatta     1920

aggtgcccat gatgaacagc aagaagtatc ctgtggccca ctttattgac cagactctga     1980

aggccaaggt gggccagctg cagctgagcc ataacctgag cctggtgatc ctggtgcccc     2040

agaacctgaa gcataggctg gaggacatgg agcaggctct gagcccctct gtgttcaagg     2100

ctattatgga gaagctggag atgagcaagt tccagcccac tctgctgacc ctgcccagaa     2160

tcaaggtgac cacctctcag gacatgctga gcatcatgga aaagctggag ttctttgact     2220

tttcttatga cctgaatctg tgtggcctga ctgaggatcc tgatctgcag gtgtctgcca     2280

tgcagcacca gactgtgctg gagctgactg agactggggt ggaggctgct gctgcttctg     2340

ccatctctgt ggccaggacc ctgctggtgt ttgaggtgca gcagcccttc ctgtttgtgc     2400

tgtgggacca gcagcacaag tttcctgtgt tcatgggcag ggtgtatgac cccagagcct     2460

ga                                                                    2462


<210>  231
<211>  2158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1co21(Intron 3-4)(SINES_LINES)CpG free

<400>  231
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggacagggcc       60

agctctaacc ccaatgctac ttctagctcc tctcaggacc ctgagagcct gcaggacagg      120

ggggagggca aggtggccac cactgtgatc tctaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac caccaacagc accaccaact ctgccactaa gatcactgcc      240

aacaccactg atgagcccac cacccagccc actactgagc ccaccaccca gcctactatc      300

cagcccaccc agcccactac ccagctgccc actgacagcc ctacccagcc caccactggc      360

agcttctgcc ctgggcctgt gaccctgtgc tctgacctgg agagccattc tactgaggct      420

gtgctggggg atgccctggt ggacttctct ctgaagctgt accatgcttt ctctgccatg      480

aagaaggtgg agactaacat ggcttttagc cccttcagca ttgctagcct gctgacccag      540

gtgctgctgg gtaagaccct gcttgaattc tctccaggtc atttgttgga cactcccata      600

agagtcacca atccagacac ttacaaagcc atgcctctgg gaagaagctg taaaaatggg      660

ctattatata ttgggggtgg ggtagaggga tgtatctttt cattcttgaa cattccatca      720

tttcacagtg atgtaatagg caccattgct tgtaaaactc tgtgactata caagaacata      780

taaaataagg tcccagccac taaccatgtt tcatggcaag gagaggtgat aagaaagatg      840

aaattattat cagaagaagc agaaagccag cagcctagtg tctgacttag tgggaggtca      900

aaaaaatgta aatcctctgc catcttgagg gattactgtc aagtcccatt tggtaattac      960

cctaggaatg gcacaaacaa attactacaa gcagtgggga cagagctatt actccccaga     1020

gagaattcta aaaaggctac agaatctttc ttgagagatt gagagaacac ttccagctca     1080

gatgatctgt gatcccctcc aaagcaggga ataccctcca ttccagcctg gtccccaacc     1140

ctcattccca aggaaggccc cccactcatc ctgcaagtat ctttcatctc tgccctttgt     1200

tgcaggggct ggggagaaca ctaagaccaa cctggaatct atcctgagct accccaagga     1260

cttcacctgt gtgcaccagg ccctgaaggg cttcaccacc aagggggtga cctctgtgag     1320

ccagatcttc cacagccctg acctggccat cagggatact tttgtgaatg ccagcagaac     1380

cctgtactct tctagcccca gggtgctgag caataattct gatgctaacc tggagctgat     1440

caatacctgg gtggctaaga ataccaacaa caagattagc aggctgctgg actctctgcc     1500

ttctgatacc aggctggtgc tgctgaatgc catttacctg tctgccaagt ggaagaccac     1560

ttttgaccct aagaagacta ggatggagcc tttccacttc aagaactctg tcattaaggt     1620

gcccatgatg aacagcaaga agtatcctgt ggcccacttt attgaccaga ctctgaaggc     1680

caaggtgggc cagctgcagc tgagccataa cctgagcctg gtgatcctgg tgccccagaa     1740

cctgaagcat aggctggagg acatggagca ggctctgagc ccctctgtgt tcaaggctat     1800

tatggagaag ctggagatga gcaagttcca gcccactctg ctgaccctgc ccagaatcaa     1860

ggtgaccacc tctcaggaca tgctgagcat catggaaaag ctggagttct ttgacttttc     1920

ttatgacctg aatctgtgtg gcctgactga ggatcctgat ctgcaggtgt ctgccatgca     1980

gcaccagact gtgctggagc tgactgagac tggggtggag gctgctgctg cttctgccat     2040

ctctgtggcc aggaccctgc tggtgtttga ggtgcagcag cccttcctgt ttgtgctgtg     2100

ggaccagcag cacaagtttc ctgtgttcat gggcagggtg tatgacccca gagcctga       2158


<210>  232
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  232
aatccaaatg ctaccagctc cagctcccag gatccagaga gtttgcaaga cagaggcgaa       60

gggaaggtcg caacaacagt tatctccaag atgctattcg ttgaacccat cctggaggtt      120

tccagcttgc cgacaaccaa ctcaacaacc aattcagcca ccaaaataac agctaatacc      180

actgatgaac ccaccacaca acccaccaca gagcccacca cccaacccac catccaaccc      240

acccaaccaa ctacccagct cccaacagat tctcctaccc agcccactac tgggtccttc      300

tgcccaggac ctgttactct ctgctctgac ttggagagtc attcaacaga ggccgtgttg      360

ggggatgctt tggtagattt ctccctgaag ctctaccacg ccttctcagc aatgaagaag      420

gtggagacca acatggcctt ttccccattc agcatcgcca gcctccttac ccaggtcctg      480

ctcggggctg gggagaacac caaaacaaac ctggagagca tcctctctta ccccaaggac      540

ttcacctgtg tccaccaggc cctgaagggc ttcacgacca aaggtgtcac ctcagtctct      600

cagattttcc acagcccaga cctggccata agggacacct ttgtgaatgc ctctcggacc      660

ctgtacagca gcagccccag agtcctaagc aacaacagtg acgccaactt ggagctcatc      720

aacacctggg tggccaagaa caccaacaac aagatcagcc ggctgctaga cagtctgccc      780

tccgataccc gccttgtcct cctcaatgct atctacctga gtgccaagtg gaagacaaca      840

tttgatccca agaaaaccag aatggaaccc tttcacttca aaaactcagt tataaaagtg      900

cccatgatga atagcaagaa gtaccctgtg gcccatttca ttgaccaaac tttgaaagcc      960

aaggtggggc agctgcagct ctcccacaat ctgagtttgg tgatcctggt accccagaac     1020

ctgaaacatc gtcttgaaga catggaacag gctctcagcc cttctgtttt caaggccatc     1080

atggagaaac tggagatgtc caagttccag cccactctcc taacactacc ccgcatcaaa     1140

gtgacgacca gccaggatat gctctcaatc atggagaaat tggaattctt cgatttttct     1200

tatgacctta acctgtgtgg gctgacagag gaccctgatc ttcaggtttc tgcgatgcag     1260

caccagacag tgctggaact gacagagact ggggtggagg cggctgcagc ctccgccatc     1320

tctgtggccc gcaccctgct ggtctttgaa gtgcagcagc ccttcctctt cgtgctctgg     1380

gaccagcagc acaagttccc tgtcttcatg gggcgagtat atgaccccag ggcctga        1437


<210>  233
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400> 233
aaccctaatg ctacctctag ctctagccag gaccctgaga gcctgcagga taggggggag       60

ggcaaggtgg ccaccactgt gatcagcaag atgctgtttg tggagcctat cctggaggtg      120

agcagcctgc ccaccaccaa ctctactacc aactctgcta ccaagatcac tgccaatacc      180

actgatgaac ccaccactca gcccactact gagcccacca cccagcccac cattcagccc      240

actcagccca ctacccagct gcctactgac tctcccaccc agcccaccac tggcagcttt      300

tgtcctggcc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt cagcctgaag ctgtaccatg ccttctctgc catgaagaag      420

gtggagacca acatggcctt cagccccttc tctattgcct ctctgctgac ccaggtgctg      480

ctgggggctg gggagaatac taagaccaac ctggagagca ttctgagcta tcccaaggac      540

ttcacctgtg tgcaccaggc cctgaagggg ttcactacta aaggggtgac ctctgtgtct      600

cagatcttcc acagccctga cctggccatc agggacactt ttgtgaatgc cagcaggacc      660

ctgtacagca gcagccccag agtgctgagc aataattctg atgctaatct ggagctgatt      720

aacacttggg tggccaagaa caccaacaac aagatctcta ggctgctgga ttctctgccc      780

tctgacacca ggctggtgct gctgaatgcc atctatctgt ctgccaagtg gaagaccacc      840

tttgatccca agaagaccag gatggagccc ttccatttca agaactctgt gattaaagtg      900

cccatgatga actctaagaa gtatcctgtg gcccacttca ttgatcagac tctgaaggcc      960

aaggtggggc agctgcagct gagccacaac ctgagcctgg tgatcctggt gccccagaat     1020

ctgaagcaca ggctggagga catggagcag gccctgagcc cctctgtgtt caaggccatc     1080

atggagaagc tggagatgag caagttccag cccaccctgc tgactctgcc cagaattaag     1140

gtgaccacca gccaggacat gctgagcatc atggagaagc tggagttctt tgacttctct     1200

tatgacctga acctgtgtgg cctgactgag gatcctgacc tgcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ctctgccatt     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagtttcc tgtgtttatg ggcagggtgt atgaccctag ggcctga        1437


<210>  234
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  234
aaccctaatg ccacctccag cagcagccag gaccctgaga gcctgcagga taggggggag       60

ggcaaggtgg ctactactgt gatcagcaag atgctgtttg tggagcctat cctggaggtg      120

agcagcctgc ccaccactaa ctctactact aattctgcca ctaagatcac tgccaatacc      180

actgatgagc caaccactca gcccaccact gagcccacca cccagcccac cattcagccc      240

actcagccta ccacccagct gcctactgac agccccactc agcccactac tggctctttc      300

tgtcctgggc ctgtgactct gtgctctgac ctggaatccc acagcactga ggctgtgctg      360

ggggatgccc tggtggattt cagcctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacca acatggcctt cagccctttc tctattgcca gcctgctgac tcaggtgctg      480

ctgggggctg gggagaatac caagaccaac ctggagtcta tcctgagcta tcccaaggac      540

ttcacttgtg tgcaccaggc cctgaagggg ttcaccacca agggggtgac ctctgtgtct      600

cagatctttc acagccctga cctggccatc agggatacct ttgtgaatgc cagcaggacc      660

ctgtacagca gcagccccag ggtgctgagc aacaactctg atgccaacct ggagctgatc      720

aacacctggg tggccaagaa caccaacaac aagatcagca ggctgctgga cagcctgccc      780

tctgatacca ggctggtgct gctgaatgcc atctacctgt ctgctaagtg gaagaccact      840

tttgatccta agaagaccag gatggagccc tttcacttca agaactctgt gatcaaggtg      900

cccatgatga actctaagaa ataccctgtg gcccacttca ttgatcagac cctgaaggcc      960

aaggtgggcc agctgcagct gagccacaac ctgagcttgg tgatcctggt gcctcagaac     1020

ctgaagcaca ggctggagga catggagcag gccctgagcc cctctgtgtt caaggccatt     1080

atggagaagc tggagatgag caagttccag cctaccctgc tgaccctgcc caggatcaag     1140

gtgactacta gccaggatat gctgagcatc atggagaagc tggagttttt tgatttcagc     1200

tatgacctga acctgtgtgg cctgactgag gaccctgacc tgcaggtgtc tgccatgcag     1260

catcagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ctctgccatc     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ctttcctgtt tgtgctgtgg     1380

gatcagcagc acaagtttcc tgtgttcatg ggcagggtgt atgaccccag ggcttga        1437


<210>  235
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  235
aaccctaatg ctacctctag ctctagccag gaccctgaga gcctgcagga taggggggag       60

ggcaaggtgg ccaccactgt gatcagcaag atgctgtttg tggagcctat cctggaggtg      120

agcagcctgc ccaccaccaa ctctactacc aactctgcta ccaagatcac tgccaatacc      180

actgatgaac ccaccactca gcccactact gagcccacca cccagcccac cattcagccc      240

actcagccca ctacccagct gcctactgac tctcccaccc agcccaccac tgggagcttc      300

tgtccaggcc ctgtgactct gtgttctgac ctggagagcc acagcactga agctgtgctg      360

ggggatgctc tggtggactt cagcctgaag ctgtaccatg ccttctctgc catgaagaag      420

gtggaaacca acatggcctt tagccccttc agcattgcta gcctgctgac tcaggtgctg      480

ctgggggctg gggagaacac taagactaac ctggagtcta tcctgtctta tcccaaggac      540

ttcacctgtg tgcatcaggc cctgaagggg ttcaccacca agggggtcac ctctgtgagc      600

cagatctttc acagccctga tctggccatc agggacacct ttgtgaatgc ctctaggact      660

ctgtacagca gcagccccag ggtgctgagc aacaactctg atgccaacct ggagctgatc      720

aacacctggg tggccaagaa cactaacaac aagatcagca ggctgctgga cagcctgccc      780

tctgacacta ggctggtgct gctgaatgcc atctatctgt ctgccaagtg gaagaccacc      840

tttgacccca agaagactag gatggagccc tttcatttta agaactctgt gatcaaggtg      900

cccatgatga acagcaagaa ataccctgtg gcccatttca ttgaccagac tctgaaggct      960

aaggtgggcc agctgcagct gagccacaac ctgagcctgg tgatcctggt gccacagaat     1020

ctgaagcaca ggctggagga catggagcag gctctgtctc cctctgtgtt caaggccatc     1080

atggagaagc tggagatgtc taagttccag cccaccctgc tgaccctgcc caggatcaag     1140

gtgaccactt ctcaggacat gctgtctatc atggagaagc tggagttttt tgacttttct     1200

tatgacctga acctgtgtgg cctgactgag gaccctgatc tgcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ttctgccatt     1320

tctgtggcta ggactctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagttccc tgtgttcatg ggcagggtgt atgatcccag ggcttga        1437


<210>  236
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  236
aaccctaatg ctacctctag ctctagccag gaccctgaga gcctgcagga taggggggag       60

ggcaaggtgg ccaccactgt gatcagcaag atgctgtttg tggagcctat cctggaggtg      120

agcagcctgc ccaccaccaa ctctactacc aactctgcta ccaagatcac tgccaatacc      180

actgatgaac ccaccactca gcccactact gagcccacca cccagcccac cattcagccc      240

actcagccca ctacccagct gcctactgac tctcccaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggattt cagcctgaag ctgtaccatg ccttctctgc catgaagaag      420

gtggagacca acatggcctt ctctcccttc agcattgcca gcctgctgac ccaggtgctg      480

ctgggggctg gggagaacac caagaccaac ctggagagca tcctgtctta ccccaaggac      540

ttcacctgtg tgcatcaggc cctgaagggc ttcactacta agggggtgac ctctgtgtct      600

cagattttcc acagccctga cctggctatt agggacactt ttgtgaatgc ttctaggacc      660

ctgtacagca gctctcccag ggtgctgagc aacaactctg atgccaacct ggagctgatt      720

aacacttggg tggccaagaa cactaacaat aagatcagca ggctgctgga cagcctgccc      780

tctgacacca ggctggtgct gctgaatgcc atctacctgt ctgccaagtg gaagactact      840

tttgatccta agaagaccag gatggagcct ttccacttca agaactctgt gatcaaggtg      900

cccatgatga attctaagaa gtaccctgtg gctcacttca ttgaccagac cctgaaggcc      960

aaggtgggcc agctgcagct gagccacaac ctgagcctgg tgattctggt gccccagaac     1020

ctgaagcaca ggctggagga catggagcag gccctgagcc cctctgtgtt caaggccatc     1080

atggagaagc tggagatgag caagttccag cctactctgc tgactctgcc caggatcaag     1140

gtgaccacta gccaggacat gctgagcatt atggagaagc tggagttctt tgacttttct     1200

tatgatctga acctgtgtgg cctgactgag gaccctgacc tgcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ctctgccatc     1320

tctgtggcta ggaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagttccc tgtcttcatg ggcagggtgt atgatcccag ggcttga        1437


<210>  237
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  237
aaccccaatg ctactagcag cagcagccag gatcctgaga gcctgcagga cagaggggaa       60

gggaaggtgg ccaccactgt gatcagcaag atgctgtttg tggagcctat cctggaggtg      120

agctctctgc ccaccactaa cagcaccacc aattctgcta ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcctaccact gagccaacta cccagcccac catccagccc      240

acccagccca ccactcagct gcctactgat tctcctactc agcctaccac tgggagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagtctc attctactga ggctgtgctg      360

ggggatgccc tggtggactt cagcctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcctt ctctcctttc tctattgcca gcctgctgac tcaggtgctg      480

ctgggggctg gggagaatac caagactaac ctggagagca tcctgtctta tcctaaggac      540

ttcacttgtg tgcatcaggc cctgaagggc ttcaccacca agggggtgac ttctgtgagc      600

cagattttcc acagccctga cctggccatc agagacacct ttgtgaatgc cagcaggacc      660

ctgtattcta gctctcccag ggtgctgagc aacaactctg atgccaatct ggaactgatc      720

aacacttggg tggccaagaa caccaacaac aagatcagca ggctgctgga tagcctgccc      780

tctgacacca ggctggtgct gctgaatgcc atctacctgt ctgccaagtg gaagaccacc      840

tttgacccca agaagactag gatggagccc ttccacttca agaactctgt gatcaaggtg      900

cccatgatga atagcaagaa gtaccctgtg gcccacttca ttgaccagac cctgaaggcc      960

aaggtggggc agctgcagct gagccacaac ctgagcctgg tgatcctggt gccccagaac     1020

ctgaagcaca gactggagga catggagcag gccctgagcc catctgtgtt caaggctatt     1080

atggagaagc tggagatgtc taagtttcag cctaccctgc tgaccctgcc caggatcaag     1140

gtgactacca gccaggacat gctgagcatc atggagaagc tggaattctt tgacttcagc     1200

tatgatctga atctgtgtgg cctgactgaa gaccctgatt tgcaggtgtc tgctatgcag     1260

caccagactg tgctggaact gactgagact ggggtggagg ctgctgctgc ctctgccatc     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ctttcctgtt tgtgctgtgg     1380

gatcagcagc acaagttccc tgtgttcatg ggcagggtgt atgaccctag ggcttga        1437


<210>  238
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  238
aaccccaatg ctacttctag ctcctctcag gaccctgaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggggctg gggagaacac taagaccaac ctggaatcta tcctgagcta ccccaaggac      540

ttcacctgtg tgcaccaggc cctgaagggc ttcaccacca agggggtgac ctctgtgagc      600

cagatcttcc acagccctga cctggccatc agggatactt ttgtgaatgc cagcagaacc      660

ctgtactctt ctagccccag ggtgctgagc aataattctg atgctaacct ggagctgatc      720

aatacctggg tggctaagaa taccaacaac aagattagca ggctgctgga ctctctgcct      780

tctgatacca ggctggtgct gctgaatgcc atttacctgt ctgccaagtg gaagaccact      840

tttgacccta agaagactag gatggagcct ttccacttca agaactctgt cattaaggtg      900

cccatgatga acagcaagaa gtatcctgtg gcccacttta ttgaccagac tctgaaggcc      960

aaggtgggcc agctgcagct gagccataac ctgagcctgg tgatcctggt gccccagaac     1020

ctgaagcata ggctggagga catggagcag gctctgagcc cctctgtgtt caaggctatt     1080

atggagaagc tggagatgag caagttccag cccactctgc tgaccctgcc cagaatcaag     1140

gtgaccacct ctcaggacat gctgagcatc atggaaaagc tggagttctt tgacttttct     1200

tatgacctga atctgtgtgg cctgactgag gatcctgatc tgcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ttctgccatc     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagtttcc tgtgttcatg ggcagggtgt atgaccccag agcctga        1437


<210>  239
<211>  1437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  239

Ala Ala Thr Cys Cys Cys Ala Ala Thr Gly Cys Cys Ala Cys Cys Thr 
1               5                   10                  15      


Cys Thr Ala Gly Cys Thr Cys Thr Ala Gly Cys Cys Ala Gly Gly Ala 
            20                  25                  30          


Thr Cys Cys Thr Gly Ala Gly Ala Gly Cys Cys Thr Gly Cys Ala Gly 
        35                  40                  45              


Gly Ala Cys Ala Gly Gly Gly Gly Gly Gly Ala Gly Gly Gly Cys Ala 
    50                  55                  60                  


Ala Gly Gly Thr Gly Gly Cys Cys Ala Cys Cys Ala Cys Thr Gly Thr 
65                  70                  75                  80  


Gly Ala Thr Cys Ala Gly Cys Ala Ala Gly Ala Thr Gly Cys Thr Gly 
                85                  90                  95      


Thr Thr Thr Gly Thr Gly Gly Ala Gly Cys Cys Cys Ala Thr Thr Cys 
            100                 105                 110         


Thr Gly Gly Ala Gly Gly Thr Gly Thr Cys Thr Thr Cys Thr Cys Thr 
        115                 120                 125             


Gly Cys Cys Cys Ala Cys Cys Ala Cys Cys Ala Ala Thr Ala Gly Cys 
    130                 135                 140                 


Ala Cys Cys Ala Cys Thr Ala Ala Thr Thr Cys Thr Gly Cys Cys Ala 
145                 150                 155                 160 


Cys Cys Ala Ala Gly Ala Thr Cys Ala Cys Thr Gly Cys Thr Ala Ala 
                165                 170                 175     


Cys Ala Cys Cys Ala Cys Thr Gly Ala Thr Gly Ala Gly Cys Cys Cys 
            180                 185                 190         


Ala Cys Cys Ala Cys Thr Cys Ala Gly Cys Cys Thr Ala Cys Cys Ala 
        195                 200                 205             


Cys Thr Gly Ala Gly Cys Cys Cys Ala Cys Cys Ala Cys Cys Cys Ala 
    210                 215                 220                 


Gly Cys Cys Cys Ala Cys Thr Ala Thr Cys Cys Ala Gly Cys Cys Cys 
225                 230                 235                 240 


Ala Cys Cys Cys Ala Gly Cys Cys Cys Ala Cys Cys Ala Cys Cys Cys 
                245                 250                 255     


Ala Gly Cys Thr Gly Cys Cys Thr Ala Cys Thr Gly Ala Cys Ala Gly 
            260                 265                 270         


Cys Cys Cys Thr Ala Cys Cys Cys Ala Gly Cys Cys Cys Ala Cys Thr 
        275                 280                 285             


Ala Cys Thr Gly Gly Gly Ala Gly Cys Thr Thr Cys Thr Gly Cys Cys 
    290                 295                 300                 


Cys Thr Gly Gly Cys Cys Cys Thr Gly Thr Gly Ala Cys Cys Cys Thr 
305                 310                 315                 320 


Gly Thr Gly Cys Thr Cys Thr Gly Ala Cys Cys Thr Gly Gly Ala Gly 
                325                 330                 335     


Ala Gly Cys Cys Ala Cys Ala Gly Cys Ala Cys Thr Gly Ala Gly Gly 
            340                 345                 350         


Cys Thr Gly Thr Gly Cys Thr Gly Gly Gly Gly Gly Ala Thr Gly Cys 
        355                 360                 365             


Cys Cys Thr Gly Gly Thr Gly Gly Ala Cys Thr Thr Cys Ala Gly Cys 
    370                 375                 380                 


Cys Thr Gly Ala Ala Gly Cys Thr Gly Thr Ala Cys Cys Ala Thr Gly 
385                 390                 395                 400 


Cys Cys Thr Thr Thr Thr Cys Thr Gly Cys Cys Ala Thr Gly Ala Ala 
                405                 410                 415     


Gly Ala Ala Gly Gly Thr Gly Gly Ala Gly Ala Cys Cys Ala Ala Cys 
            420                 425                 430         


Ala Thr Gly Gly Cys Cys Thr Thr Thr Ala Gly Cys Cys Cys Thr Thr 
        435                 440                 445             


Thr Cys Ala Gly Cys Ala Thr Thr Gly Cys Cys Ala Gly Cys Cys Thr 
    450                 455                 460                 


Gly Cys Thr Gly Ala Cys Thr Cys Ala Gly Gly Thr Gly Cys Thr Gly 
465                 470                 475                 480 


Cys Thr Gly Gly Gly Gly Gly Cys Thr Gly Gly Gly Gly Ala Gly Ala 
                485                 490                 495     


Ala Cys Ala Cys Cys Ala Ala Gly Ala Cys Cys Ala Ala Cys Cys Thr 
            500                 505                 510         


Gly Gly Ala Gly Ala Gly Cys Ala Thr Cys Cys Thr Gly Ala Gly Cys 
        515                 520                 525             


Thr Ala Cys Cys Cys Cys Ala Ala Gly Gly Ala Cys Thr Thr Cys Ala 
    530                 535                 540                 


Cys Thr Thr Gly Thr Gly Thr Gly Cys Ala Cys Cys Ala Gly Gly Cys 
545                 550                 555                 560 


Cys Cys Thr Gly Ala Ala Gly Gly Gly Cys Thr Thr Cys Ala Cys Thr 
                565                 570                 575     


Ala Cys Cys Ala Ala Gly Gly Gly Gly Gly Thr Gly Ala Cys Thr Thr 
            580                 585                 590         


Cys Thr Gly Thr Gly Ala Gly Cys Cys Ala Gly Ala Thr Cys Thr Thr 
        595                 600                 605             


Cys Cys Ala Cys Ala Gly Cys Cys Cys Thr Gly Ala Cys Cys Thr Gly 
    610                 615                 620                 


Gly Cys Cys Ala Thr Cys Ala Gly Gly Gly Ala Thr Ala Cys Thr Thr 
625                 630                 635                 640 


Thr Thr Gly Thr Gly Ala Ala Thr Gly Cys Cys Ala Gly Cys Ala Gly 
                645                 650                 655     


Gly Ala Cys Cys Cys Thr Gly Thr Ala Cys Ala Gly Cys Ala Gly Cys 
            660                 665                 670         


Ala Gly Cys Cys Cys Cys Ala Gly Gly Gly Thr Gly Cys Thr Gly Ala 
        675                 680                 685             


Gly Cys Ala Ala Cys Ala Ala Cys Thr Cys Thr Gly Ala Thr Gly Cys 
    690                 695                 700                 


Thr Ala Ala Cys Cys Thr Gly Gly Ala Gly Cys Thr Gly Ala Thr Cys 
705                 710                 715                 720 


Ala Ala Thr Ala Cys Thr Thr Gly Gly Gly Thr Gly Gly Cys Cys Ala 
                725                 730                 735     


Ala Gly Ala Ala Cys Ala Cys Cys Ala Ala Cys Ala Ala Cys Ala Ala 
            740                 745                 750         


Gly Ala Thr Thr Thr Cys Thr Ala Gly Gly Cys Thr Gly Cys Thr Gly 
        755                 760                 765             


Gly Ala Cys Thr Cys Thr Cys Thr Gly Cys Cys Cys Thr Cys Thr Gly 
    770                 775                 780                 


Ala Cys Ala Cys Thr Ala Gly Gly Cys Thr Gly Gly Thr Gly Cys Thr 
785                 790                 795                 800 


Gly Cys Thr Gly Ala Ala Thr Gly Cys Cys Ala Thr Cys Thr Ala Cys 
                805                 810                 815     


Cys Thr Gly Thr Cys Thr Gly Cys Cys Ala Ala Gly Thr Gly Gly Ala 
            820                 825                 830         


Ala Gly Ala Cys Cys Ala Cys Cys Thr Thr Thr Gly Ala Thr Cys Cys 
        835                 840                 845             


Cys Ala Ala Gly Ala Ala Gly Ala Cys Thr Ala Gly Gly Ala Thr Gly 
    850                 855                 860                 


Gly Ala Gly Cys Cys Cys Thr Thr Cys Cys Ala Cys Thr Thr Cys Ala 
865                 870                 875                 880 


Ala Gly Ala Ala Cys Thr Cys Thr Gly Thr Gly Ala Thr Cys Ala Ala 
                885                 890                 895     


Gly Gly Thr Gly Cys Cys Cys Ala Thr Gly Ala Thr Gly Ala Ala Cys 
            900                 905                 910         


Ala Gly Cys Ala Ala Gly Ala Ala Gly Thr Ala Cys Cys Cys Thr Gly 
        915                 920                 925             


Thr Gly Gly Cys Cys Cys Ala Thr Thr Thr Cys Ala Thr Thr Gly Ala 
    930                 935                 940                 


Cys Cys Ala Gly Ala Cys Cys Cys Thr Gly Ala Ala Gly Gly Cys Cys 
945                 950                 955                 960 


Ala Ala Gly Gly Thr Gly Gly Gly Gly Cys Ala Gly Cys Thr Gly Cys 
                965                 970                 975     


Ala Gly Cys Thr Gly Ala Gly Cys Cys Ala Cys Ala Ala Thr Cys Thr 
            980                 985                 990         


Gly Ala Gly Cys Cys Thr Gly Gly  Thr Gly Ala Thr Thr  Cys Thr Gly 
        995                 1000                 1005             


Gly Thr  Gly Cys Cys Cys Cys  Ala Gly Ala Ala Thr  Cys Thr Gly 
    1010                 1015                 1020             


Ala Ala  Gly Cys Ala Cys Ala  Gly Ala Cys Thr Gly  Gly Ala Gly 
    1025                 1030                 1035             


Gly Ala  Cys Ala Thr Gly Gly  Ala Gly Cys Ala Gly  Gly Cys Thr 
    1040                 1045                 1050             


Cys Thr  Gly Thr Cys Thr Cys  Cys Cys Thr Cys Thr  Gly Thr Gly 
    1055                 1060                 1065             


Thr Thr  Cys Ala Ala Gly Gly  Cys Cys Ala Thr Cys  Ala Thr Gly 
    1070                 1075                 1080             


Gly Ala  Gly Ala Ala Gly Cys  Thr Gly Gly Ala Gly  Ala Thr Gly 
    1085                 1090                 1095             


Ala Gly  Cys Ala Ala Gly Thr  Thr Cys Cys Ala Gly  Cys Cys Cys 
    1100                 1105                 1110             


Ala Cys  Thr Cys Thr Gly Cys  Thr Gly Ala Cys Thr  Cys Thr Gly 
    1115                 1120                 1125             


Cys Cys  Thr Ala Gly Gly Ala  Thr Cys Ala Ala Gly  Gly Thr Gly 
    1130                 1135                 1140             


Ala Cys  Cys Ala Cys Cys Ala  Gly Cys Cys Ala Gly  Gly Ala Cys 
    1145                 1150                 1155             


Ala Thr  Gly Cys Thr Gly Ala  Gly Cys Ala Thr Thr  Ala Thr Gly 
    1160                 1165                 1170             


Gly Ala  Gly Ala Ala Gly Cys  Thr Gly Gly Ala Gly  Thr Thr Cys 
    1175                 1180                 1185             


Thr Thr  Thr Gly Ala Cys Thr  Thr Cys Ala Gly Cys  Thr Ala Thr 
    1190                 1195                 1200             


Gly Ala  Cys Cys Thr Gly Ala  Ala Cys Cys Thr Gly  Thr Gly Thr 
    1205                 1210                 1215             


Gly Gly  Cys Cys Thr Gly Ala  Cys Thr Gly Ala Gly  Gly Ala Cys 
    1220                 1225                 1230             


Cys Cys  Thr Gly Ala Thr Cys  Thr Gly Cys Ala Gly  Gly Thr Gly 
    1235                 1240                 1245             


Thr Cys  Thr Gly Cys Cys Ala  Thr Gly Cys Ala Gly  Cys Ala Cys 
    1250                 1255                 1260             


Cys Ala  Gly Ala Cys Thr Gly  Thr Gly Cys Thr Gly  Gly Ala Gly 
    1265                 1270                 1275             


Cys Thr  Gly Ala Cys Thr Gly  Ala Gly Ala Cys Thr  Gly Gly Gly 
    1280                 1285                 1290             


Gly Thr  Gly Gly Ala Gly Gly  Cys Thr Gly Cys Thr  Gly Cys Thr 
    1295                 1300                 1305             


Gly Cys  Cys Thr Cys Thr Gly  Cys Thr Ala Thr Thr  Thr Cys Thr 
    1310                 1315                 1320             


Gly Thr  Gly Gly Cys Cys Ala  Gly Gly Ala Cys Cys  Cys Thr Gly 
    1325                 1330                 1335             


Cys Thr  Gly Gly Thr Gly Thr  Thr Thr Gly Ala Gly  Gly Thr Gly 
    1340                 1345                 1350             


Cys Ala  Gly Cys Ala Gly Cys  Cys Cys Thr Thr Cys  Cys Thr Gly 
    1355                 1360                 1365             


Thr Thr  Thr Gly Thr Gly Cys  Thr Gly Thr Gly Gly  Gly Ala Cys 
    1370                 1375                 1380             


Cys Ala  Gly Cys Ala Gly Cys  Ala Cys Ala Ala Gly  Thr Thr Thr 
    1385                 1390                 1395             


Cys Cys  Thr Gly Thr Gly Thr  Thr Cys Ala Thr Gly  Gly Gly Gly 
    1400                 1405                 1410             


Ala Gly  Gly Gly Thr Gly Thr  Ala Thr Gly Ala Cys  Cys Cys Cys 
    1415                 1420                 1425             


Ala Gly  Gly Gly Cys Cys Thr  Gly Ala 
    1430                 1435         


<210>  240
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  240
aatccaaatg ctaccagctc ctcctcccag gatcctgaat cccttcaaga caggggggag       60

ggcaaggtgg caactactgt gatttccaag atgctgtttg tggagcccat cctggaggtt      120

agcagccttc ctactaccaa ctcaacaacc aattcagcca ccaaaattac agctaatacc      180

acagatgagc caacaactca acccaccact gagcccacca ctcagccaac catccaaccc      240

acccaaccaa ctacccagct cccaacagat tctcctaccc agcctaccac tggctccttc      300

tgcccaggac ctgttactct ctgctctgac ttggaaagcc attctactga ggctgtcctg      360

ggggatgctt tggtagactt ctccctgaag ctctaccatg cattttcagc aatgaagaag      420

gtggagacca acatggcctt ttccccattc agtatagcaa gtctcctgac tcaggtcctg      480

ctgggggcag gggagaatac aaagaccaac ctggagagca tcctcagtta tcccaaggac      540

ttcacctgtg tccaccaggc cctgaagggc ttcacaacaa agggggtgac ctcagtctct      600

cagattttcc acagcccaga cctggccata agggacacct ttgtgaatgc ctctaggacc      660

ctgtactcaa gctcccccag agtcctaagc aacaacagtg atgcaaattt ggagctcatc      720

aacacctggg tggccaagaa caccaacaac aagatcagca ggctgctaga cagtctgcca      780

agtgatacaa ggcttgtcct cctcaatgct atctacctga gtgccaagtg gaagacaaca      840

tttgatccca agaaaaccag aatggaaccc tttcacttca aaaactcagt tataaaagtg      900

cccatgatga atagcaagaa gtaccctgtg gcccatttca ttgaccaaac tttgaaagcc      960

aaggtggggc agctgcagct ctcccacaat ctgagtctgg taatcctggt accccagaac     1020

ctgaaacata ggcttgaaga catggaacag gctctcagcc cttctgtttt caaggccata     1080

atggagaagc tggagatgtc caagttccag cccactctcc taacactacc caggatcaaa     1140

gtgacaacca gccaggatat gctctcaatc atggagaaat tggaattttt tgatttttct     1200

tatgacctta acctgtgtgg gctgacagag gaccctgatc ttcaggtttc tgcaatgcag     1260

caccagacag tgctggaact gacagagact ggggtggaag ctgctgcagc aagtgcaata     1320

tctgtggcca gaaccctgct ggtctttgaa gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagttccc tgtcttcatg gggagggtat atgaccccag ggcctga        1437


<210>  241
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  241
aaccccaatg caaccagcag ttcctctcag gatccagagt ccctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctccaag atgctgtttg tggagcccat cctggaggta      120

tccagcctcc ctaccaccaa cagcaccacc aactcagcca ccaaaatcac tgctaacacc      180

actgatgagc ccacaaccca gccaactact gagccaacca ctcagcctac catccaaccc      240

acccagccta ctacccagct ccccactgac tctcctaccc agcccaccac tggcagcttc      300

tgcccaggac ctgtgaccct ctgctctgac ttggagtccc attccacaga ggcagtgctg      360

ggggatgccc tggtagactt ctccctgaag ctctaccatg cattctctgc catgaagaag      420

gtggagacca acatggcctt ctcccccttc agcattgcca gcctcctgac ccaggtcctg      480

ctgggggcag gggagaacac aaagacaaac ctggagtcca tcctcagcta ccccaaggac      540

ttcacctgtg tccaccaggc cctgaagggc ttcacaacca agggggtgac cagtgtctca      600

cagattttcc acagcccaga cctggccatc agggacacct ttgtgaatgc cagtaggacc      660

ctgtacagct ccagtcccag agtcctcagc aacaactctg atgccaacct ggagctgatc      720

aacacctggg tggccaagaa caccaacaac aagatcagca ggctgctaga ctcactgccc      780

tctgacacaa ggctggtcct cctcaatgca atctacctga gtgccaagtg gaagaccacc      840

tttgacccca agaagaccag gatggagccc ttccacttca agaacagtgt cattaaggtg      900

cccatgatga acagcaagaa gtaccctgtg gcccacttca ttgaccagac cttgaaggcc      960

aaggtggggc agctgcagct ctcccacaac ctgtcactgg tcatcctggt tccccagaac     1020

ctgaagcaca ggcttgagga catggagcag gccctcagcc cttctgtatt caaggccata     1080

atggagaagc tggagatgag caagttccag cccactctgc tgaccctacc caggatcaag     1140

gtgaccacca gccaggacat gctctcaatc atggagaagt tggagttctt tgacttcagc     1200

tatgacctga acctgtgtgg gctgacagag gaccctgacc tgcaggtgtc agccatgcag     1260

caccagacag tgctggaact gacagagact ggggtggaag ctgctgcagc aagtgctatt     1320

tcagtggcca ggaccctgct ggtctttgag gtccagcagc ccttcctgtt tgtgctctgg     1380

gaccagcagc acaagttccc tgtcttcatg gggagggtct atgaccccag ggcctga        1437


<210>  242
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  242
aaccccaatg ccaccagctc cagctctcag gacccagaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccacagt gatcagcaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctcc ccaccaccaa cagcaccacc aattctgcca ccaagatcac agccaacacc      180

acagatgagc ccacaaccca gcctaccaca gagccaacca cacagcccac catccaaccc      240

acccaaccta ctacccagct gcccacagac agccctaccc agcctaccac aggcagcttc      300

tgccctggcc ctgtgaccct gtgctctgac ttggagagcc actccacaga ggctgtgctg      360

ggggatgccc tggtggattt cagcctgaag ctgtaccatg ccttctctgc catgaagaag      420

gtggagacca acatggcctt cagccccttc agcattgcca gcctcctgac ccaggtcctg      480

ctgggggctg gggagaacac aaagaccaac ctggagagca tcctgagcta ccccaaggac      540

ttcacctgtg tgcaccaggc cctgaagggc ttcaccacca agggggtgac ctctgtgagc      600

cagattttcc acagccctga cctggccatc agggacacct ttgtgaatgc ctccaggacc      660

ctgtacagct ctagccccag ggtgctgagc aacaactctg atgccaactt ggagctgatc      720

aacacctggg tggccaagaa caccaacaac aagatcagca ggctgctgga cagcctgccc      780

tctgacacca ggctggtgct cctgaatgcc atctacctgt ctgccaagtg gaagaccacc      840

tttgacccca agaagaccag aatggagccc ttccacttca agaactctgt gataaaggtg      900

cccatgatga acagcaagaa gtaccctgtg gcccacttca ttgaccagac cctgaaagcc      960

aaggtgggcc agctgcagct cagccacaac ctgagcctgg tcatcctggt gccccagaac     1020

ctgaagcaca ggctggagga catggaacag gccctcagcc cctctgtgtt caaggccatt     1080

atggagaagc tggagatgag caagttccag cccactctgc tgacactgcc caggatcaag     1140

gtgaccacca gccaggacat gctgagcatc atggagaagt tggagttctt tgacttcagc     1200

tatgacctga acctgtgtgg cctgacagag gaccctgacc tccaggtgtc tgccatgcag     1260

caccagacag tgctggaact gacagagaca ggggtggaag ctgctgctgc ctctgccatc     1320

tctgtggcca gaaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagttccc tgtgttcatg ggcagggtgt atgaccccag ggcctga        1437


<210>  243
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  243
aaccccaatg ctacttctag ctcctctcag gaccctgaga gccttcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggggctg gggagaacac taagaccaac ctggaatcta tcctgagcta ccccaaggac      540

ttcacctgtg tgcaccaggc cctgaagggc ttcaccacca agggggtgac ctctgtgagc      600

cagatcttcc acagccctga cctggccatc agggatactt ttgtgaatgc cagcagaacc      660

ctgtactctt ctagccccag ggtgctgagc aataattctg atgctaacct ggagctgatc      720

aatacctggg tggctaagaa taccaacaac aagattagca ggctgctgga ctctctgcct      780

tctgatacca ggctggtgct gctgaatgcc atttacctgt ctgccaagtg gaagaccact      840

tttgacccta agaagactag gatggagcct ttccacttca agaactctgt cattaaggtg      900

cccatgatga acagcaagaa gtatcctgtg gcccacttta ttgaccagac tctgaaggcc      960

aaggtgggcc agcttcagct gagccataac ctgagcctgg tgatcctggt gccccagaac     1020

ctgaagcata ggctggagga catggagcag gctctgagcc cctctgtgtt caaggctatt     1080

atggagaagc tggagatgag caagttccag cccactctgc tgaccctgcc cagaatcaag     1140

gtgaccacct ctcaggacat gctgagcatc atggaaaagc tggagttctt tgacttttct     1200

tatgacctga atctgtgtgg cctgactgag gatcctgatc ttcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ttctgccatc     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagtttcc tgtgttcatg ggcagggtgt atgaccccag agcctga        1437


<210>  244
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  244
aatcccacca tccaacccac ccaaccaact acccagctcc caacagattc tcctacccag       60

cccactactg ggtccttctg cccaggacct gttactctct gctctgactt ggagagtcat      120

tcaacagagg ccgtgttggg ggatgctttg gtagatttct ccctgaagct ctaccacgcc      180

ttctcagcaa tgaagaaggt ggagaccaac atggcctttt ccccattcag catcgccagc      240

ctccttaccc aggtcctgct cggggctggg gagaacacca aaacaaacct ggagagcatc      300

ctctcttacc ccaaggactt cacctgtgtc caccaggccc tgaagggctt cacgaccaaa      360

ggtgtcacct cagtctctca gattttccac agcccagacc tggccataag ggacaccttt      420

gtgaatgcct ctcggaccct gtacagcagc agccccagag tcctaagcaa caacagtgac      480

gccaacttgg agctcatcaa cacctgggtg gccaagaaca ccaacaacaa gatcagccgg      540

ctgctagaca gtctgccctc cgatacccgc cttgtcctcc tcaatgctat ctacctgagt      600

gccaagtgga agacaacatt tgatcccaag aaaaccagaa tggaaccctt tcacttcaaa      660

aactcagtta taaaagtgcc catgatgaat agcaagaagt accctgtggc ccatttcatt      720

gaccaaactt tgaaagccaa ggtggggcag ctgcagctct cccacaatct gagtttggtg      780

atcctggtac cccagaacct gaaacatcgt cttgaagaca tggaacaggc tctcagccct      840

tctgttttca aggccatcat ggagaaactg gagatgtcca agttccagcc cactctccta      900

acactacccc gcatcaaagt gacgaccagc caggatatgc tctcaatcat ggagaaattg      960

gaattcttcg atttttctta tgaccttaac ctgtgtgggc tgacagagga ccctgatctt     1020

caggtttctg cgatgcagca ccagacagtg ctggaactga cagagactgg ggtggaggcg     1080

gctgcagcct ccgccatctc tgtggcccgc accctgctgg tctttgaagt gcagcagccc     1140

ttcctcttcg tgctctggga ccagcagcac aagttccctg tcttcatggg gcgagtatat     1200

gaccccaggg cctga                                                      1215


<210>  245
<211>  1149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  245
aatgggtcct tctgcccagg acctgttact ctctgctctg acttggagag tcattcaaca       60

gaggccgtgt tgggggatgc tttggtagat ttctccctga agctctacca cgccttctca      120

gcaatgaaga aggtggagac caacatggcc ttttccccat tcagcatcgc cagcctcctt      180

acccaggtcc tgctcggggc tggggagaac accaaaacaa acctggagag catcctctct      240

taccccaagg acttcacctg tgtccaccag gccctgaagg gcttcacgac caaaggtgtc      300

acctcagtct ctcagatttt ccacagccca gacctggcca taagggacac ctttgtgaat      360

gcctctcgga ccctgtacag cagcagcccc agagtcctaa gcaacaacag tgacgccaac      420

ttggagctca tcaacacctg ggtggccaag aacaccaaca acaagatcag ccggctgcta      480

gacagtctgc cctccgatac ccgccttgtc ctcctcaatg ctatctacct gagtgccaag      540

tggaagacaa catttgatcc caagaaaacc agaatggaac cctttcactt caaaaactca      600

gttataaaag tgcccatgat gaatagcaag aagtaccctg tggcccattt cattgaccaa      660

actttgaaag ccaaggtggg gcagctgcag ctctcccaca atctgagttt ggtgatcctg      720

gtaccccaga acctgaaaca tcgtcttgaa gacatggaac aggctctcag cccttctgtt      780

ttcaaggcca tcatggagaa actggagatg tccaagttcc agcccactct cctaacacta      840

ccccgcatca aagtgacgac cagccaggat atgctctcaa tcatggagaa attggaattc      900

ttcgattttt cttatgacct taacctgtgt gggctgacag aggaccctga tcttcaggtt      960

tctgcgatgc agcaccagac agtgctggaa ctgacagaga ctggggtgga ggcggctgca     1020

gcctccgcca tctctgtggc ccgcaccctg ctggtctttg aagtgcagca gcccttcctc     1080

ttcgtgctct gggaccagca gcacaagttc cctgtcttca tggggcgagt atatgacccc     1140

agggcctga                                                             1149


<210>  246
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  246
aaccccaatg ctacttctag ctcctctcag gaccctgaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggggctg gggagaacac taagaccaac ctggaatcta tcctgagcta ccccaaggac      540

ttcacctgtg tgcaccaggc cctgaagggc ttcaccacca agggggtgac ctctgtgagc      600

cagatcttcc acagccctga cctggccatc agggatactt ttgtgaatgc cagcagaacc      660

ctgtactctt ctagccccag ggtgctgagc aataattctg atgctaacct ggagctgatc      720

aatacctggg tggctaagaa taccaacaac aagattagca ggctgctgga ctctctgcct      780

tctgatacca ggctggtgct gctgaatgcc atttacctgt ctgccaagtg gaagaccact      840

tttgacccta agaagactag gatggagcct ttccacttca agaactctgt cattaaggtg      900

cccatgatga acagcaagaa gtatcctgtg gcccacttta ttgaccagac tctgaaggcc      960

aaggtgggcc agctgcagct gagccataac ctgagcctgg tgatcctggt gccccagaac     1020

ctgaagcata ggctggagga catggagcag gctctgagcc cctctgtgtt caaggctatt     1080

atggagaagc tggagatgag caagttccag cccactctgc tgaccctgcc cagaatcaag     1140

gtgaccacct ctcaggacat gctgagcatc atggaaaagc tggagttctt tgacttttct     1200

tatgacctga atctgtgtgg cctgactgag gatcctgatc tgcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ttctgccatc     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagtttcc tgtgttcatg ggcagggtgt atgaccccag agcctga        1437


<210>  247
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  247
aaccccaatg ctacttctag ctcctctcag gaccctgaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggggctg gggagaacac taagaccaac ctggaatcta tcctgagcta ccccaaggac      540

ttcacctgtg tgcaccaggc cctgaagggc ttcaccacca agggggtgac ctctgtgagc      600

cagatcttcc acagccctga cctggccatc agggatactt ttgtgaatgc cagcagaacc      660

ctgtactctt ctagccccag ggtgctgagc aataattctg atgctaacct ggagctgatc      720

aatacctggg tggctaagaa taccaacaac aagattagca ggctgctgga ctctctgcct      780

tctgatacca ggctggtgct gctgaatgcc atttacctgt ctgccaagtg gaagaccact      840

tttgacccta agaagactag gatggagcct ttccacttca agaactctgt cattaaggtg      900

cccatgatga acagcaagaa gtatcctgtg gcccacttta ttgaccagac tctgaaggcc      960

aaggtgggcc agctgcagct gagccataac ctgagcctgg tgatcctggt gccccagaac     1020

ctgaagcata ggctggagga catggagcag gctctgagcc cctctgtgtt caaggctatt     1080

atggagaagc tggagatgag caagttccag cccactctgc tgaccctgcc cagaatcaag     1140

gtgaccacct ctcaggacat gctgagcatc atggaaaagc tggagttctt tgacttttct     1200

tatgacctga atctgtgtgg cctgactgag gatcctgatc tgcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ttctgccatc     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagtttcc tgtgttcatg ggcagggtgt atgaccccag agcctga        1437


<210>  248
<211>  3094
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  248
aaccccaatg ctacttctag ctcctctcag gaccctgaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggtaaga ccctgcttga attctctcca ggtcatttgt tggacactcc cataagagtc      540

accaatccag acacttacaa agccatgcct ctgggaagaa gctgtaaaaa tgggctatta      600

tatattgggg gtggggtaga gggatgtatc ttttcattct tgaacattcc atcatttcac      660

agtgatgtaa taggcacgat tgcttgtaaa actctgtgac tatacaagaa catataaaat      720

aaggtcgcag ccactaacca tgtttcatgg caaggagagg tgataagaaa gatgaaatta      780

ggcgcagtgg ctcacgcctg taatcccagc actttgggag gccaaggcgg gtggatcacc      840

tgaggtcagg agttcaagac cagcctggcc aacatggtga aaccctgtct ctactaaaaa      900

tacaaaaatt atcagggagt ggtggtgcat gcctgtaatc ccagctactt gggcagctga      960

ggcaggagaa tcgcttgaac ccaggaggtg gaggttgcag tgagccgaga ccgcaccatt     1020

gcactacagt ctgggtgaca gagcgagact ctgtctcaaa aaaaaaaaaa aattatcaga     1080

gatagaccta gagtagatgt ggttagtact gccttctagc tctgtgacct tgggcagatc     1140

actttaacct ctctgagcct tgagtcctct tgtgtaaaat agtgatgatg ctatctacct     1200

caaaagatta agaagcagaa agccaggccg gatgcggtgg ttcacacctg taatcccagc     1260

attttaggag gccgaggcgg gcagatcacg aggtcaggag ttcgagacca gcctgactaa     1320

catggtgaaa ccccgtctct actaaaaata aaaagaaatt agctaggcat ggtggtgcac     1380

acctgtaacc ccagctactc aggaggctga ggcaggagaa tcacttgaac acgggaggca     1440

gaggttgcag tgagccgaaa tcatgccact gcactccagc ctgggaagac tgagcaagac     1500

tctgtctcaa aaaaaaaaaa gaagcagcct agtgtctgac ttagtgggag gtcaaaaaaa     1560

tgtaaatcct ctgccatctt gagggattac tgtcaagtcc catttggtaa ttaccctagg     1620

aatggcacaa acaaattact acaagcagtg gggacagagc tattactccc cagagagaat     1680

tctaaaaagg ctacagaatc tttcttggct gggcacggtg actcacacct ataatcctgg     1740

cactttggga ggccaaggca ggagttcaag accagcctgg ccaacatgtt gaaaccccat     1800

ctctactaaa aatgcaaaaa ttagccaggc atagtgatgc atgcttattg tcccagctac     1860

ttgggaggca gaggtgggag gattgcttga acctggagat tcaagtgagc tgagattgca     1920

ccactgcatt ccagcctggg caacaaagca agactctgtc tcaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaga gagattgaga gaacacttcc agctcagatg atctgtgatc ccctccaaag     2040

cagggaatac cctccattcc agcctggtcc ccaaccctca ttcccaagga aggcccccga     2100

ctcatcctgc aagtatcttt catctctgcc ctttgttgca ggggctgggg agaacactaa     2160

gaccaacctg gaatctatcc tgagctaccc caaggacttc acctgtgtgc accaggccct     2220

gaagggcttc accaccaagg gggtgacctc tgtgagccag atcttccaca gccctgacct     2280

ggccatcagg gatacttttg tgaatgccag cagaaccctg tactcttcta gccccagggt     2340

gctgagcaat aattctgatg ctaacctgga gctgatcaat acctgggtgg ctaagaatac     2400

caacaacaag attagcaggc tgctggactc tctgccttct gataccaggc tggtgctgct     2460

gaatgccatt tacctgtctg ccaagtggaa gaccactttt gaccctaaga agactaggat     2520

ggagcctttc cacttcaaga actctgtcat taaggtgccc atgatgaaca gcaagaagta     2580

tcctgtggcc cactttattg accagactct gaaggccaag gtgggccagc tgcagctgag     2640

ccataacctg agcctggtga tcctggtgcc ccagaacctg aagcataggc tggaggacat     2700

ggagcaggct ctgagcccct ctgtgttcaa ggctattatg gagaagctgg agatgagcaa     2760

gttccagccc actctgctga ccctgcccag aatcaaggtg accacctctc aggacatgct     2820

gagcatcatg gaaaagctgg agttctttga cttttcttat gacctgaatc tgtgtggcct     2880

gactgaggat cctgatctgc aggtgtctgc catgcagcac cagactgtgc tggagctgac     2940

tgagactggg gtggaggctg ctgctgcttc tgccatctct gtggccagga ccctgctggt     3000

gtttgaggtg cagcagccct tcctgtttgt gctgtgggac cagcagcaca agtttcctgt     3060

gttcatgggc agggtgtatg accccagagc ctga                                 3094


<210>  249
<211>  2092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  249
aaccccaatg ctacttctag ctcctctcag gaccctgaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggtaaga ccctgcttga attctctcca ggtcatttgt tggacactcc cataagagtc      540

accaatccag acacttacaa agccatgcct ctgggaagaa gctgtaaaaa tgggctatta      600

tatattgggg gtggggtaga gggatgtatc ttttcattct tgaacattcc atcatttcac      660

agtgatgtaa taggcaccat tgcttgtaaa actctgtgac tatacaagaa catataaaat      720

aaggtcccag ccactaacca tgtttcatgg caaggagagg tgataagaaa gatgaaatta      780

ttatcagaag aagcagaaag ccagcagcct agtgtctgac ttagtgggag gtcaaaaaaa      840

tgtaaatcct ctgccatctt gagggattac tgtcaagtcc catttggtaa ttaccctagg      900

aatggcacaa acaaattact acaagcagtg gggacagagc tattactccc cagagagaat      960

tctaaaaagg ctacagaatc tttcttgaga gattgagaga acacttccag ctcagatgat     1020

ctgtgatccc ctccaaagca gggaataccc tccattccag cctggtcccc aaccctcatt     1080

cccaaggaag gccccccact catcctgcaa gtatctttca tctctgccct ttgttgcagg     1140

ggctggggag aacactaaga ccaacctgga atctatcctg agctacccca aggacttcac     1200

ctgtgtgcac caggccctga agggcttcac caccaagggg gtgacctctg tgagccagat     1260

cttccacagc cctgacctgg ccatcaggga tacttttgtg aatgccagca gaaccctgta     1320

ctcttctagc cccagggtgc tgagcaataa ttctgatgct aacctggagc tgatcaatac     1380

ctgggtggct aagaatacca acaacaagat tagcaggctg ctggactctc tgccttctga     1440

taccaggctg gtgctgctga atgccattta cctgtctgcc aagtggaaga ccacttttga     1500

ccctaagaag actaggatgg agcctttcca cttcaagaac tctgtcatta aggtgcccat     1560

gatgaacagc aagaagtatc ctgtggccca ctttattgac cagactctga aggccaaggt     1620

gggccagctg cagctgagcc ataacctgag cctggtgatc ctggtgcccc agaacctgaa     1680

gcataggctg gaggacatgg agcaggctct gagcccctct gtgttcaagg ctattatgga     1740

gaagctggag atgagcaagt tccagcccac tctgctgacc ctgcccagaa tcaaggtgac     1800

cacctctcag gacatgctga gcatcatgga aaagctggag ttctttgact tttcttatga     1860

cctgaatctg tgtggcctga ctgaggatcc tgatctgcag gtgtctgcca tgcagcacca     1920

gactgtgctg gagctgactg agactggggt ggaggctgct gctgcttctg ccatctctgt     1980

ggccaggacc ctgctggtgt ttgaggtgca gcagcccttc ctgtttgtgc tgtgggacca     2040

gcagcacaag tttcctgtgt tcatgggcag ggtgtatgac cccagagcct ga             2092


<210>  250
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  250
aatccaaatg ctaccagctc cagctcccag gatccagaga gtttgcaaga cagaggcgaa       60

gggaaggtcg caacaacagt tatctccaag atgctattcg ttgaacccat cctggaggtt      120

tccagcttgc cgacaaccaa ctcaacaacc aattcagcca ccaaaataac agctaatacc      180

actgatgaac ccaccacaca acccaccaca gagcccacca cccaacccac catccaaccc      240

acccaaccaa ctacccagct cccaacagat tctcctaccc agcccactac tgggtccttc      300

tgcccaggac ctgttactct ctgctctgac ttggagagtc attcaacaga ggccgtgttg      360

ggggatgctt tggtagattt ctccctgaag ctctaccacg ccttctcagc aatgaagaag      420

gtggagacca acatggcctt ttccccattc agcatcgcca gcctccttac ccaggtcctg      480

ctcggggctg gggagaacac caaaacaaac ctggagagca tcctctctta ccccaaggac      540

ttcacctgtg tccaccaggc cctgaagggc ttcacgacca aaggtgtcac ctcagtctct      600

cagattttcc acagcccaga cctggccata agggacacct ttgtgaatgc ctctcggacc      660

ctgtacagca gcagccccag agtcctaagc aacaacagtg acgccaactt ggagctcatc      720

aacacctggg tggccaagaa caccaacaac aagatcagcc ggctgctaga cagtctgccc      780

tccgataccc gccttgtcct cctcaatgct atctacctga gtgccaagtg gaagacaaca      840

tttgatccca agaaaaccag aatggaaccc tttcacttca aaaactcagt tataaaagtg      900

cccatgatga atagcaagaa gtaccctgtg gcccatttca ttgaccaaac tttgaaagcc      960

aaggtggggc agctgcagct ctcccacaat ctgagtttgg tgatcctggt accccagaac     1020

ctgaaacatc gtcttgaaga catggaacag gctctcagcc cttctgtttt caaggccatc     1080

atggagaaac tggagatgtc caagttccag cccactctcc taacactacc ccgcatcaaa     1140

gtgacgacca gccaggatat gctctcaatc atggagaaat tggaattctt cgatttttct     1200

tatgacctta acctgtgtgg gctgacagag gaccctgatc ttcaggtttc tgcgatgcag     1260

caccagacag tgctggaact gacagagact ggggtggagg cggctgcagc ctccgccatc     1320

tctgtggccc gcaccctgct ggtctttgaa gtgcagcagc ccttcctctt cgtgctctgg     1380

gaccagcagc acaagttccc tgtcttcatg gggcgagtat atgaccccag ggccgacaaa     1440

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     1500

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1560

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1620

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1680

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1740

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1800

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1860

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1920

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1980

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2040

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     2100

ctgtctccgg gt                                                         2112


<210>  251
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  251
aatccaaatg ctaccagctc cagctcccag gatccagaga gtttgcaaga cagaggcgaa       60

gggaaggtcg caacaacagt tatctccaag atgctattcg ttgaacccat cctggaggtt      120

tccagcttgc cgacaaccaa ctcaacaacc aattcagcca ccaaaataac agctaatacc      180

actgatgaac ccaccacaca acccaccaca gagcccacca cccaacccac catccaaccc      240

acccaaccaa ctacccagct cccaacagat tctcctaccc agcccactac tgggtccttc      300

tgcccaggac ctgttactct ctgctctgac ttggagagtc attcaacaga ggccgtgttg      360

ggggatgctt tggtagattt ctccctgaag ctctaccacg ccttctcagc aatgaagaag      420

gtggagacca acatggcctt ttccccattc agcatcgcca gcctccttac ccaggtcctg      480

ctcggggctg gggagaacac caaaacaaac ctggagagca tcctctctta ccccaaggac      540

ttcacctgtg tccaccaggc cctgaagggc ttcacgacca aaggtgtcac ctcagtctct      600

cagattttcc acagcccaga cctggccata agggacacct ttgtgaatgc ctctcggacc      660

ctgtacagca gcagccccag agtcctaagc aacaacagtg acgccaactt ggagctcatc      720

aacacctggg tggccaagaa caccaacaac aagatcagcc ggctgctaga cagtctgccc      780

tccgataccc gccttgtcct cctcaatgct atctacctga gtgccaagtg gaagacaaca      840

tttgatccca agaaaaccag aatggaaccc tttcacttca aaaactcagt tataaaagtg      900

cccatgatga atagcaagaa gtaccctgtg gcccatttca ttgaccaaac tttgaaagcc      960

aaggtggggc agctgcagct ctcccacaat ctgagtttgg tgatcctggt accccagaac     1020

ctgaaacatc gtcttgaaga catggaacag gctctcagcc cttctgtttt caaggccatc     1080

atggagaaac tggagatgtc caagttccag cccactctcc taacactacc ccgcatcaaa     1140

gtgacgacca gccaggatat gctctcaatc atggagaaat tggaattctt cgatttttct     1200

tatgacctta acctgtgtgg gctgacagag gaccctgatc ttcaggtttc tgcgatgcag     1260

caccagacag tgctggaact gacagagact ggggtggagg cggctgcagc ctccgccatc     1320

tctgtggccc gcaccctgct ggtctttgaa gtgcagcagc ccttcctctt cgtgctctgg     1380

gaccagcagc acaagttccc tgtcttcatg gggcgagtat atgaccccag ggccgacaaa     1440

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     1500

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1560

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1620

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1680

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1740

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1800

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1860

gtcaatctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1920

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1980

tccttcttcc tcaatagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2040

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     2100

ctgtctccgg gt                                                         2112


<210>  252
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  252
aatccaaatg ctaccagctc cagctcccag gatccagaga gtttgcaaga cagaggcgaa       60

gggaaggtcg caacaacagt tatctccaag atgctattcg ttgaacccat cctggaggtt      120

tccagcttgc cgacaaccaa ctcaacaacc aattcagcca ccaaaataac agctaatacc      180

actgatgaac ccaccacaca acccaccaca gagcccacca cccaacccac catccaaccc      240

acccaaccaa ctacccagct cccaacagat tctcctaccc agcccactac tgggtccttc      300

tgcccaggac ctgttactct ctgctctgac ttggagagtc attcaacaga ggccgtgttg      360

ggggatgctt tggtagattt ctccctgaag ctctaccacg ccttctcagc aatgaagaag      420

gtggagacca acatggcctt ttccccattc agcatcgcca gcctccttac ccaggtcctg      480

ctcggggctg gggagaacac caaaacaaac ctggagagca tcctctctta ccccaaggac      540

ttcacctgtg tccaccaggc cctgaagggc ttcacgacca aaggtgtcac ctcagtctct      600

cagattttcc acagcccaga cctggccata agggacacct ttgtgaatgc ctctcggacc      660

ctgtacagca gcagccccag agtcctaagc aacaacagtg acgccaactt ggagctcatc      720

aacacctggg tggccaagaa caccaacaac aagatcagcc ggctgctaga cagtctgccc      780

tccgataccc gccttgtcct cctcaatgct atctacctga gtgccaagtg gaagacaaca      840

tttgatccca agaaaaccag aatggaaccc tttcacttca aaaactcagt tataaaagtg      900

cccatgatga atagcaagaa gtaccctgtg gcccatttca ttgaccaaac tttgaaagcc      960

aaggtggggc agctgcagct ctcccacaat ctgagtttgg tgatcctggt accccagaac     1020

ctgaaacatc gtcttgaaga catggaacag gctctcagcc cttctgtttt caaggccatc     1080

atggagaaac tggagatgtc caagttccag cccactctcc taacactacc ccgcatcaaa     1140

gtgacgacca gccaggatat gctctcaatc atggagaaat tggaattctt cgatttttct     1200

tatgacctta acctgtgtgg gctgacagag gaccctgatc ttcaggtttc tgcgatgcag     1260

caccagacag tgctggaact gacagagact ggggtggagg cggctgcagc ctccgccatc     1320

tctgtggccc gcaccctgct ggtctttgaa gtgcagcagc ccttcctctt cgtgctctgg     1380

gaccagcagc acaagttccc tgtcttcatg gggcgagtat atgaccccag ggccgacaaa     1440

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     1500

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1560

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1620

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1680

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1740

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1800

ccccgagaac cacaggtgta caccaagccc ccatcccggg atgagctgac caagaaccag     1860

gtcagcctga gctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1920

agcaatgggc agccggagaa caactacaag accacggtgc ccgtgctgga ctccgacggc     1980

tccttcagac tcgccagcta cctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2040

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     2100

ctgtctccgg gt                                                         2112


<210>  253
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  253
aatccaaatg ctaccagctc cagctcccag gatccagaga gtttgcaaga cagaggcgaa       60

gggaaggtcg caacaacagt tatctccaag atgctattcg ttgaacccat cctggaggtt      120

tccagcttgc cgacaaccaa ctcaacaacc aattcagcca ccaaaataac agctaatacc      180

actgatgaac ccaccacaca acccaccaca gagcccacca cccaacccac catccaaccc      240

acccaaccaa ctacccagct cccaacagat tctcctaccc agcccactac tgggtccttc      300

tgcccaggac ctgttactct ctgctctgac ttggagagtc attcaacaga ggccgtgttg      360

ggggatgctt tggtagattt ctccctgaag ctctaccacg ccttctcagc aatgaagaag      420

gtggagacca acatggcctt ttccccattc agcatcgcca gcctccttac ccaggtcctg      480

ctcggggctg gggagaacac caaaacaaac ctggagagca tcctctctta ccccaaggac      540

ttcacctgtg tccaccaggc cctgaagggc ttcacgacca aaggtgtcac ctcagtctct      600

cagattttcc acagcccaga cctggccata agggacacct ttgtgaatgc ctctcggacc      660

ctgtacagca gcagccccag agtcctaagc aacaacagtg acgccaactt ggagctcatc      720

aacacctggg tggccaagaa caccaacaac aagatcagcc ggctgctaga cagtctgccc      780

tccgataccc gccttgtcct cctcaatgct atctacctga gtgccaagtg gaagacaaca      840

tttgatccca agaaaaccag aatggaaccc tttcacttca aaaactcagt tataaaagtg      900

cccatgatga atagcaagaa gtaccctgtg gcccatttca ttgaccaaac tttgaaagcc      960

aaggtggggc agctgcagct ctcccacaat ctgagtttgg tgatcctggt accccagaac     1020

ctgaaacatc gtcttgaaga catggaacag gctctcagcc cttctgtttt caaggccatc     1080

atggagaaac tggagatgtc caagttccag cccactctcc taacactacc ccgcatcaaa     1140

gtgacgacca gccaggatat gctctcaatc atggagaaat tggaattctt cgatttttct     1200

tatgacctta acctgtgtgg gctgacagag gaccctgatc ttcaggtttc tgcgatgcag     1260

caccagacag tgctggaact gacagagact ggggtggagg cggctgcagc ctccgccatc     1320

tctgtggccc gcaccctgct ggtctttgaa gtgcagcagc ccttcctctt cgtgctctgg     1380

gaccagcagc acaagttccc tgtcttcatg gggcgagtat atgaccccag ggccgacaaa     1440

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     1500

ttccccccaa aacccaagga caccctctac atcacccggg agcctgaggt cacatgcgtg     1560

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1620

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1680

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1740

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1800

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1860

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1920

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1980

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2040

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     2100

ctgtctccgg gt                                                         2112


<210>  254
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  254
aatccaaatg ctaccagctc cagctcccag gatccagaga gtttgcaaga cagaggcgaa       60

gggaaggtcg caacaacagt tatctccaag atgctattcg ttgaacccat cctggaggtt      120

tccagcttgc cgacaaccaa ctcaacaacc aattcagcca ccaaaataac agctaatacc      180

actgatgaac ccaccacaca acccaccaca gagcccacca cccaacccac catccaaccc      240

acccaaccaa ctacccagct cccaacagat tctcctaccc agcccactac tgggtccttc      300

tgcccaggac ctgttactct ctgctctgac ttggagagtc attcaacaga ggccgtgttg      360

ggggatgctt tggtagattt ctccctgaag ctctaccacg ccttctcagc aatgaagaag      420

gtggagacca acatggcctt ttccccattc agcatcgcca gcctccttac ccaggtcctg      480

ctcggggctg gggagaacac caaaacaaac ctggagagca tcctctctta ccccaaggac      540

ttcacctgtg tccaccaggc cctgaagggc ttcacgacca aaggtgtcac ctcagtctct      600

cagattttcc acagcccaga cctggccata agggacacct ttgtgaatgc ctctcggacc      660

ctgtacagca gcagccccag agtcctaagc aacaacagtg acgccaactt ggagctcatc      720

aacacctggg tggccaagaa caccaacaac aagatcagcc ggctgctaga cagtctgccc      780

tccgataccc gccttgtcct cctcaatgct atctacctga gtgccaagtg gaagacaaca      840

tttgatccca agaaaaccag aatggaaccc tttcacttca aaaactcagt tataaaagtg      900

cccatgatga atagcaagaa gtaccctgtg gcccatttca ttgaccaaac tttgaaagcc      960

aaggtggggc agctgcagct ctcccacaat ctgagtttgg tgatcctggt accccagaac     1020

ctgaaacatc gtcttgaaga catggaacag gctctcagcc cttctgtttt caaggccatc     1080

atggagaaac tggagatgtc caagttccag cccactctcc taacactacc ccgcatcaaa     1140

gtgacgacca gccaggatat gctctcaatc atggagaaat tggaattctt cgatttttct     1200

tatgacctta acctgtgtgg gctgacagag gaccctgatc ttcaggtttc tgcgatgcag     1260

caccagacag tgctggaact gacagagact ggggtggagg cggctgcagc ctccgccatc     1320

tctgtggccc gcaccctgct ggtctttgaa gtgcagcagc ccttcctctt cgtgctctgg     1380

gaccagcagc acaagttccc tgtcttcatg gggcgagtat atgaccccag ggccgacaaa     1440

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     1500

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1560

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1620

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1680

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1740

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1800

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1860

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1920

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1980

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2040

ttctcatgct ccgtgctgca tgaggctctg cacagccact acacgcagaa gagcctctcc     2100

ctgtctccgg gt                                                         2112


<210>  255
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  255
aatccaaatg ctaccagctc cagctcccag gatccagaga gtttgcaaga cagaggcgaa       60

gggaaggtcg caacaacagt tatctccaag atgctattcg ttgaacccat cctggaggtt      120

tccagcttgc cgacaaccaa ctcaacaacc aattcagcca ccaaaataac agctaatacc      180

actgatgaac ccaccacaca acccaccaca gagcccacca cccaacccac catccaaccc      240

acccaaccaa ctacccagct cccaacagat tctcctaccc agcccactac tgggtccttc      300

tgcccaggac ctgttactct ctgctctgac ttggagagtc attcaacaga ggccgtgttg      360

ggggatgctt tggtagattt ctccctgaag ctctaccacg ccttctcagc aatgaagaag      420

gtggagacca acatggcctt ttccccattc agcatcgcca gcctccttac ccaggtcctg      480

ctcggggctg gggagaacac caaaacaaac ctggagagca tcctctctta ccccaaggac      540

ttcacctgtg tccaccaggc cctgaagggc ttcacgacca aaggtgtcac ctcagtctct      600

cagattttcc acagcccaga cctggccata agggacacct ttgtgaatgc ctctcggacc      660

ctgtacagca gcagccccag agtcctaagc aacaacagtg acgccaactt ggagctcatc      720

aacacctggg tggccaagaa caccaacaac aagatcagcc ggctgctaga cagtctgccc      780

tccgataccc gccttgtcct cctcaatgct atctacctga gtgccaagtg gaagacaaca      840

tttgatccca agaaaaccag aatggaaccc tttcacttca aaaactcagt tataaaagtg      900

cccatgatga atagcaagaa gtaccctgtg gcccatttca ttgaccaaac tttgaaagcc      960

aaggtggggc agctgcagct ctcccacaat ctgagtttgg tgatcctggt accccagaac     1020

ctgaaacatc gtcttgaaga catggaacag gctctcagcc cttctgtttt caaggccatc     1080

atggagaaac tggagatgtc caagttccag cccactctcc taacactacc ccgcatcaaa     1140

gtgacgacca gccaggatat gctctcaatc atggagaaat tggaattctt cgatttttct     1200

tatgacctta acctgtgtgg gctgacagag gaccctgatc ttcaggtttc tgcgatgcag     1260

caccagacag tgctggaact gacagagact ggggtggagg cggctgcagc ctccgccatc     1320

tctgtggccc gcaccctgct ggtctttgaa gtgcagcagc ccttcctctt cgtgctctgg     1380

gaccagcagc acaagttccc tgtcttcatg gggcgagtat atgaccccag ggccgacaaa     1440

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     1500

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgagat cacatgcgtg     1560

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1620

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1680

gtcagcgtcc tcaccttcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1740

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1800

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1860

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1920

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1980

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2040

ttctcatgct ccgtgctgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     2100

ctgtctccgg gt                                                         2112


<210>  256
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  256
aaccccaatg ctacttctag ctcctctcag gaccctgaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctcagac ctggagagcc actctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtatcatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggggctg gggagaacac taagaccaac ctggaatcta tcctgagcta ccccaaggac      540

ttcacctgtg tgcaccaggc cctgaagggc ttcaccacca agggggtgac ctctgtgagc      600

cagatcttcc acagccctga cctggccatc agggatactt ttgtgaatgc cagcagaacc      660

ctgtactctt ctagccccag ggtgctgagc aataattctg atgctaacct ggagctgatc      720

aatacctggg tggctaagaa taccaacaac aagattagca ggctgctgga ctctctgcct      780

tctgatacca ggctggtgct gctgaatgcc atttacctgt ctgccaagtg gaagaccact      840

tttgacccta agaagactag gatggagcct ttccacttca agaactctgt cattaaggtg      900

cccatgatga acagcaagaa gtatcctgtg gcccacttta ttgaccagac tctgaaggcc      960

aaggtgggcc agctgcagct gagccacaac ctgagcctgg tgatcctggt gccccagaac     1020

ctgaagcaca ggctggagga catggagcag gctctgagcc cctctgtgtt caaggctatt     1080

atggagaagc tggagatgag caagttccag cccactctgc tgaccctgcc cagaatcaag     1140

gtgaccacct ctcaggacat gctgagcatc atggaaaagc tggagttctt tgacttttct     1200

tatgacctga atctgtgtgg cctgactgag gatcctgatc tgcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ttctgccatc     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagtttcc tgtgttcatg ggcagggtgt atgaccccag agcctga        1437


<210>  257
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  257
aaccccaatg ctacttctag ctcctctcag gaccctgaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggggctg gggagaacac taagaccaac ctggaatcta tcctgagcta ccccaaggac      540

ttcacctgtg tgcaccaggc cctgaagggc ttcaccacca agggggtgac ctctgtgagc      600

cagatcttcc acagccctga cctggccatc agggatactt ttgtgaatgc cagcagaacc      660

ctgtactctt ctagccccag ggtgctgagc aataattctg atgctaacct ggagctgatc      720

aatacctggg tggctaagaa taccaacaac aagattagca ggctgctgga ctctctgcct      780

tctgatacca ggctggtgct gctgaatgcc atttacctgt ctgccaagtg gaagaccact      840

tttgacccta agaagactag gatggagcct ttccacttca agaactctgt cattaaggtg      900

cccatgatga acagcaagaa gtatcctgtg gcccacttta ttgaccagac tctgaaggcc      960

aaggtgggcc agctgcagct gagccataac ctgagcctgg tgatcctggt gccccagaac     1020

ctgaagcata ggctggagga catggagcag gctctgagcc cctctgtgtt caaggctatt     1080

atggagaagc tggagatgag caagttccag cccactctgc tgaccctgcc cagaatcaag     1140

gtgaccacct ctcaggacat gctgagcatc atggaaaagc tggagttctt tgacttttct     1200

tatgacctga atctgtgtgg cctgactgag gatcctgatc tgcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ttctgccatc     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagtttcc tgtgttcatg ggcagggtgt atgaccccag agcctga        1437


<210>  258
<211>  2092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  258
aaccccaatg ctacttctag ctcctctcag gaccctgaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggtaaga ccctgcttga attctctcca ggtcatttgt tggacactcc cataagagtc      540

accaatccag acacttacaa agccatgcct ctgggaagaa gctgtaaaaa tgggctatta      600

tatattgggg gtggggtaga gggatgtatc ttttcattct tgaacattcc atcatttcac      660

agtgatgtaa taggcacgat tgcttgtaaa actctgtgac tatacaagaa catataaaat      720

aaggtcgcag ccactaacca tgtttcatgg caaggagagg tgataagaaa gatgaaatta      780

ttatcagaag aagcagaaag ccagcagcct agtgtctgac ttagtgggag gtcaaaaaaa      840

tgtaaatcct ctgccatctt gagggattac tgtcaagtcc catttggtaa ttaccctagg      900

aatggcacaa acaaattact acaagcagtg gggacagagc tattactccc cagagagaat      960

tctaaaaagg ctacagaatc tttcttgaga gattgagaga acacttccag ctcagatgat     1020

ctgtgatccc ctccaaagca gggaataccc tccattccag cctggtcccc aaccctcatt     1080

cccaaggaag gcccccgact catcctgcaa gtatctttca tctctgccct ttgttgcagg     1140

ggctggggag aacactaaga ccaacctgga atctatcctg agctacccca aggacttcac     1200

ctgtgtgcac caggccctga agggcttcac caccaagggg gtgacctctg tgagccagat     1260

cttccacagc cctgacctgg ccatcaggga tacttttgtg aatgccagca gaaccctgta     1320

ctcttctagc cccagggtgc tgagcaataa ttctgatgct aacctggagc tgatcaatac     1380

ctgggtggct aagaatacca acaacaagat tagcaggctg ctggactctc tgccttctga     1440

taccaggctg gtgctgctga atgccattta cctgtctgcc aagtggaaga ccacttttga     1500

ccctaagaag actaggatgg agcctttcca cttcaagaac tctgtcatta aggtgcccat     1560

gatgaacagc aagaagtatc ctgtggccca ctttattgac cagactctga aggccaaggt     1620

gggccagctg cagctgagcc ataacctgag cctggtgatc ctggtgcccc agaacctgaa     1680

gcataggctg gaggacatgg agcaggctct gagcccctct gtgttcaagg ctattatgga     1740

gaagctggag atgagcaagt tccagcccac tctgctgacc ctgcccagaa tcaaggtgac     1800

cacctctcag gacatgctga gcatcatgga aaagctggag ttctttgact tttcttatga     1860

cctgaatctg tgtggcctga ctgaggatcc tgatctgcag gtgtctgcca tgcagcacca     1920

gactgtgctg gagctgactg agactggggt ggaggctgct gctgcttctg ccatctctgt     1980

ggccaggacc ctgctggtgt ttgaggtgca gcagcccttc ctgtttgtgc tgtgggacca     2040

gcagcacaag tttcctgtgt tcatgggcag ggtgtatgac cccagagcct ga             2092


<210>  259
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  259
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagc                                                                  66


<210>  260
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  260
atggccagca ggctgaccct gctgactctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagc                                                                  66


<210>  261
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  261
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagc                                                                  66


<210>  262
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  262
atggctagca gactgactct gctgaccctg ctgctgctgc tgctggctgg ggacagggcc       60

agcagc                                                                  66


<210>  263
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  263
atggccagca ggctgaccct gctgaccctg ctgctgctcc tgctggctgg ggatagggcc       60

agcagc                                                                  66


<210>  264
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  264
atggcctcta ggctgactct gctgactctg ctgctcctgc tgctggctgg ggacagggcc       60

agctct                                                                  66


<210>  265
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  265
atggctagca ggctgaccct gctgaccctg ctgctcctgc tgctggctgg ggacagggcc       60

tctagc                                                                  66


<210>  266
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  266
atggcctcca ggctgaccct gctgaccctc ctgctgctcc tgctggctgg ggatagagcc       60

tctagc                                                                  66


<210>  267
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  267
atggcctcca ggctgaccct gctcaccctc ctgctgctcc tgctggctgg ggacagggcc       60

tccagc                                                                  66


<210>  268
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding signal sequence

<400>  268
atggcctcca ggctgaccct gctgaccctc ctgctgctcc tgctggctgg ggacagagcc       60

agcagc                                                                  66


<210>  269
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encoding SERPING1

<400>  269
aaccccaatg ctacttctag ctcctctcag gaccctgaga gcctgcagga caggggggag       60

ggcaaggtgg ccaccactgt gatctctaag atgctgtttg tggagcccat cctggaggtg      120

agcagcctgc ccaccaccaa cagcaccacc aactctgcca ctaagatcac tgccaacacc      180

actgatgagc ccaccaccca gcccactact gagcccacca cccagcctac tatccagccc      240

acccagccca ctacccagct gcccactgac agccctaccc agcccaccac tggcagcttc      300

tgccctgggc ctgtgaccct gtgctctgac ctggagagcc attctactga ggctgtgctg      360

ggggatgccc tggtggactt ctctctgaag ctgtaccatg ctttctctgc catgaagaag      420

gtggagacta acatggcttt tagccccttc agcattgcta gcctgctgac ccaggtgctg      480

ctgggggctg gggagaacac taagaccaac ctggaatcta tcctgagcta ccccaaggac      540

ttcacctgtg tgcaccaggc cctgaagggc ttcaccacca agggggtgac ctctgtgagc      600

cagatcttcc acagccctga cctggccatc agggatactt ttgtgaatgc cagcagaacc      660

ctgtactctt ctagccccag ggtgctgagc aataattctg atgctaacct ggagctgatc      720

aatacctggg tggctaagaa taccaacaac aagattagca ggctgctgga ctctctgcct      780

tctgatacca ggctggtgct gctgaatgcc atttacctgt ctgccaagtg gaagaccact      840

tttgacccta agaagactag gatggagcct ttccacttca agaactctgt cattaaggtg      900

cccatgatga acagcaagaa gtatcctgtg gcccacttta ttgaccagac tctgaaggcc      960

aaggtgggcc agctgcagct gagccataac ctgagcctgg tgatcctggt gccccagaac     1020

ctgaagcata ggctggagga catggagcag gctctgagcc cctctgtgtt caaggctatt     1080

atggagaagc tggagatgag caagttccag cccactctgc tgaccctgcc cagaatcaag     1140

gtgaccacct ctcaggacat gctgagcatc atggaaaagc tggagttctt tgacttttct     1200

tatgacctga atctgtgtgg cctgactgag gatcctgatc tgcaggtgtc tgccatgcag     1260

caccagactg tgctggagct gactgagact ggggtggagg ctgctgctgc ttctgccatc     1320

tctgtggcca ggaccctgct ggtgtttgag gtgcagcagc ccttcctgtt tgtgctgtgg     1380

gaccagcagc acaagtttcc tgtgttcatg ggcagggtgt atgaccccag agcctga        1437



