                               SEQUENCE LISTING

<110> SIGILON THERAPEUTICS, INC.
 
<120> COMPOSITIONS, DEVICES AND METHODS FOR INDUCING ANTIGEN-SPECIFIC 
      IMMUNE TOLERANCE

<130> S2225-7039WO

<140> PCT/US2022/013943
<141> 2022-01-26

<150> 63/141,892
<151> 2021-01-26

<160> 36    

<170> PatentIn version 3.5

<210> 1
<211> 178
<212> PRT
<213> Homo sapiens

<400> 1
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 2
<211> 537
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atgcactcta gcgccctgct gtgttgtctg gtgctgctga caggcgtcag agcctctcct       60

ggacagggaa cccagagcga gaatagctgc acccactttc caggcaacct gcctaacatg      120

ctgcgggacc tgagagatgc cttcagcaga gtgaaaacat tcttccagat gaaggaccag      180

ctggacaacc tgctgctgaa agagagcctg ctggaagatt tcaagggcta cctgggctgt      240

caggccctga gcgagatgat ccagttctac ctggaagaag tgatgcccca ggccgagaat      300

caggaccccg atattaaggc ccacgtgaac agcctgggcg agaacctgaa aaccctgcgg      360

ctgagactgc ggcggtgcca cagatttctg ccctgcgaga acaagagcaa ggccgtggaa      420

caagtgaaga acgccttcaa caagctgcaa gagaagggca tctacaaggc catgtccgag      480

ttcgacatct tcatcaacta catcgaggcc tacatgacca tgaagatccg gaactaa         537


<210> 3
<211> 181
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser 
            20                  25                  30          


Cys Thr His Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg 
        35                  40                  45              


Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu 
    50                  55                  60                  


Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr 
65                  70                  75                  80  


Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu 
                85                  90                  95      


Val Met Pro Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val 
            100                 105                 110         


Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg 
        115                 120                 125             


Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln 
    130                 135                 140                 


Val Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala 
145                 150                 155                 160 


Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr 
                165                 170                 175     


Met Lys Ile Arg Asn 
            180     


<210> 4
<211> 546
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgggctggc gcgccgccgg cgccctgctg ctggccctgc tgctgcacgg ccgcctgctg       60

gccagccccg gccagggcac ccagagcgag aacagctgca cccacttccc cggcaacctg      120

cccaacatgc tgcgcgacct gcgcgacgcc ttcagccgcg tgaagacctt cttccagatg      180

aaggaccagc tggacaacct gctgctgaag gagagcctgc tggaggactt caagggctac      240

ctgggctgcc aggccctgag cgagatgatc cagttctacc tggaggaggt gatgccccag      300

gccgagaacc aggaccccga catcaaggcc cacgtgaaca gcctgggcga gaacctgaag      360

accctgcgcc tgcgcctgcg ccgctgccac cgcttcctgc cctgcgagaa caagagcaag      420

gccgtggagc aggtgaagaa cgccttcaac aagctgcagg agaagggcat ctacaaggcc      480

atgagcgagt tcgacatctt catcaactac atcgaggcct acatgaccat gaagatccgc      540

aactaa                                                                 546


<210> 5
<211> 546
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctg       60

gcttctcctg gacagggcac acagagcgag aacagctgca cacacttccc cggcaacctg      120

cctaacatgc tgcgggatct gagagatgcc ttcagccgcg tgaaaacatt cttccagatg      180

aaggaccagc tggacaacct gctgctgaaa gagagcctgc tggaagattt caagggctac      240

ctgggctgtc aggccctgag cgagatgatc cagttctacc tggaagaagt gatgccccag      300

gccgagaatc aggaccccga tattaaggcc cacgtgaaca gcctgggcga gaacctgaaa      360

accctgcggc tgagactgcg gcggtgccac agatttctgc cctgcgagaa caagagcaag      420

gccgtggaac aagtgaagaa cgccttcaac aagctgcaag agaagggcat ctacaaggcc      480

atgtccgagt tcgacatctt catcaactac atcgaggcct acatgaccat gaagatccgg      540

aactaa                                                                 546


<210> 6
<211> 178
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Ile Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Ile Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Asn Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Leu Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 7
<211> 534
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atgcactcta gcgccctgct gtgttgtctg gtgctgctga caggcgtcag agcctctcct       60

ggacagggaa cccagagcga gaatagctgc acccactttc caggcatcct gcctaacatg      120

ctgcgggacc tgagagatgc cttcagcaga gtgaaaacat tcttccagat gaaggaccag      180

ctggacaacc tgctgctgaa agagagcctg ctggaagatt tcaagggcta cctgggctgt      240

caggccctga gcgagatgat ccagttctac ctggaagaag tgatgcccca ggccgagaat      300

caggaccccg atattaaggc ccacgtgatc agcctgggcg agaacctgaa taccctgcgg      360

ctgagactgc ggagatgcca cagactgctg ccctgcgaga acaagagcaa ggccgtggaa      420

caagtgaaga acgccttcaa caagctgcaa gagaagggca tctacaaggc catgtccgag      480

ttcgacatct tcatcaacta catcgaggcc tacatgacca tgaagatccg gaac            534


<210> 8
<211> 179
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210> 9
<211> 540
<212> DNA
<213> Homo sapiens

<400> 9
atggccgccc tgcagaaatc tgtgagctct ttccttatgg ggaccctggc caccagctgc       60

ctccttctct tggccctctt ggtacaggga ggagcagctg cgcccatcag ctcccactgc      120

aggcttgaca agtccaactt ccagcagccc tatatcacca accgcacctt catgctggct      180

aaggaggcta gcttggctga taacaacaca gacgttcgtc tcattgggga gaaactgttc      240

cacggagtca gtatgagtga gcgctgctat ctgatgaagc aggtgctgaa cttcaccctt      300

gaagaagtgc tgttccctca atctgatagg ttccagcctt atatgcagga ggtggtgccc      360

ttcctggcca ggctcagcaa caggctaagc acatgtcata ttgaaggtga tgacctgcat      420

atccagagga atgtgcaaaa gctgaaggac acagtgaaaa agcttggaga gagtggagag      480

atcaaagcaa ttggagaact ggatttgctg tttatgtctc tgagaaatgc ctgcatttga      540


<210> 10
<211> 540
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atggccgctc tgcagaaaag cgtgtccagc ttcctgatgg gcaccctggc cacatcttgt       60

ctgctgctgc ttgccctgct ggtgcaaggc ggagctgctg cccctatcag ctctcactgc      120

agactggaca agagcaactt ccagcagcct tacatcacca accggacctt catgctggcc      180

aaagaagcca gcctggccga caacaatacc gacgtgcggc tgatcggcga gaagctgttt      240

catggcgtgt ccatgagcga gcggtgctac ctgatgaagc aggtcctgaa cttcaccctg      300

gaagaggtgc tgttccctca gagcgaccgg tttcagccct acatgcaaga ggtggtgccc      360

ttcctggcca gactgagcaa cagactgtcc acctgtcaca tcgagggcga cgacctgcac      420

atccagagaa acgtgcagaa actgaaggac accgtgaaga agctgggcga gagcggagag      480

atcaaggcca tcggagaact ggacctgctg ttcatgagcc tgcggaacgc ctgtatctaa      540


<210> 11
<211> 167
<212> PRT
<213> Homo sapiens

<400> 11
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys 
            20                  25                  30          


Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala 
        35                  40                  45              


Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly 
    50                  55                  60                  


Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met 
65                  70                  75                  80  


Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser 
                85                  90                  95      


Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg 
            100                 105                 110         


Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His 
        115                 120                 125             


Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly 
    130                 135                 140                 


Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met 
145                 150                 155                 160 


Ser Leu Arg Asn Ala Cys Ile 
                165         


<210> 12
<211> 504
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctg       60

gccgctccta tcagcagcca ctgcagactg gacaagagca acttccagca gccttacatc      120

accaaccgga ccttcatgct ggccaaagaa gccagcctgg ccgacaacaa taccgacgtg      180

cggctgatcg gcgagaagct gtttcatggc gtgtccatga gcgagcggtg ctacctgatg      240

aagcaggtcc tgaacttcac cctggaagag gtgctgttcc ctcagagcga ccggtttcag      300

ccctacatgc aagaggtggt gcccttcctg gccagactga gcaacagact gtccacctgt      360

cacatcgagg gcgacgacct gcacatccag agaaacgtgc agaaactgaa ggacaccgtg      420

aagaagctgg gcgagagcgg agagatcaag gccatcggag aactggacct gctgttcatg      480

agcctgcgga acgcctgtat ctaa                                             504


<210> 13
<211> 223
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210> 14
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
            20                  25                  30          


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
        35                  40                  45              


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
    50                  55                  60                  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
65                  70                  75                  80  


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
                85                  90                  95      


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
            100                 105                 110         


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
        115                 120                 125             


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
    130                 135                 140                 


Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        275                 280                 285             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375             


<210> 15
<211> 1137
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctg       60

gccatgcatg tggctcagcc tgctgtggtg ctggcctctt ctagaggaat cgccagcttc      120

gtgtgcgagt acgcctctcc tggaaaggcc actgaagtgc gcgtgaccgt tctgagacag      180

gccgatagcc aagtgaccga agtgtgcgcc gccacctaca tgatgggcaa cgagctgacc      240

ttcctggacg acagcatctg taccggcacc agctccggca atcaagtgaa cctgaccatc      300

cagggcctga gagccatgga taccggcctg tacatctgca aggtggaact gatgtaccct      360

cctccttact acctcggcat cggcaacggc acccagatct acgtgatcga ccctgagcct      420

tgtcctgaca gcgaccaaga gcctaagagc agcgacaaga cccacacaag ccctccatct      480

ccagctccag aactgctcgg cggcagctcc gtgtttctgt tccctccaaa gcctaaggac      540

accctgatga tcagcagaac ccctgaagtg acctgcgtgg tggtggatgt gtcccacgag      600

gatcccgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc      660

aagcctagag aggaacagta caacagcacc tacagagtgg tgtccgtgct gaccgtgctg      720

caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct      780

gctcctatcg agaaaaccat cagcaaggcc aagggccagc ctagggaacc ccaggtttac      840

acactgcctc caagccggga tgagctgacc aagaatcagg tgtccctgac ctgcctggtc      900

aagggcttct acccttccga tatcgccgtg gaatgggaga gcaatggcca gcctgagaac      960

aactacaaga ccacacctcc tgtgctggac agcgacggct cattcttcct gtacagcaag     1020

ctgacagtgg acaagagcag atggcagcag ggcaacgtgt tcagctgcag cgtgatgcac     1080

gaggccctgc acaaccacta cacccagaag tccctgtctc tgagccctgg caaataa        1137


<210> 16
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
            20                  25                  30          


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
        35                  40                  45              


Lys Tyr Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
    50                  55                  60                  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
65                  70                  75                  80  


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
                85                  90                  95      


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
            100                 105                 110         


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly 
        115                 120                 125             


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
    130                 135                 140                 


Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        275                 280                 285             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375             


<210> 17
<211> 235
<212> PRT
<213> Homo sapiens

<400> 17
Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210> 18
<211> 174
<212> PRT
<213> Homo sapiens

<400> 18
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 
            20                  25                  30          


Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 
        35                  40                  45              


Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 
    50                  55                  60                  


Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 
65                  70                  75                  80  


Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 
                85                  90                  95      


Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 
            100                 105                 110         


Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 
        115                 120                 125             


Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 
    130                 135                 140                 


Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 
145                 150                 155                 160 


Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Ala Pro 
                165                 170                 


<210> 19
<211> 522
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctg       60

gccacacagg actgcagctt tcagcacagc cccatcagca gcgacttcgc cgtgaagatc      120

agagagctga gcgactacct gctgcaggac taccctgtga ccgtggctag caacctgcag      180

gacgaagaac tgtgtggtgg actgtggcga ctggtgctgg ctcagagatg gatggaacgg      240

ctgaaaacag tggccggcag caagatgcag ggcctgctgg aaagagtgaa caccgagatc      300

cacttcgtga ccaagtgcgc cttccagcct cctccaagct gcctgagatt cgtgcagacc      360

aacatcagca ggctgctgca agagacatcc gagcagctgg tggccctgaa gccttggatc      420

accagacaga acttcagccg gtgcctggaa ctgcagtgtc agcccgatag cagcacactg      480

cctccacctt ggagccccag acctctggaa gctacagctc ct                         522


<210> 20
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala 
            20      


<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210> 22
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210> 23
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala 
            20              


<210> 24
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr 
        


<210> 25
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg 
            20                  25                  30      


<210> 26
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly 
            20                  25                  


<210> 27
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210> 28
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210> 29
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Met Arg Pro Thr Trp Ala Trp Trp Leu Phe Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Leu Trp Ala Pro Ala Arg Gly 
            20              


<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala 
            20      


<210> 31
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210> 32
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210> 33
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala 
        


<210> 34
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Gly Arg Gly Asp Ser Pro 
1               5       


<210> 35
<211> 1137
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
atgggctggc gagctgctgg tgcacttctg ctggctctgc tgcttcatgg cagactgctg       60

gccatgcatg tggctcagcc tgctgtggtg ctggcctctt ctagaggaat cgccagcttc      120

gtgtgcgagt acgcctctcc tggcaagtac accgaagtgc gcgtgaccgt tctgagacag      180

gccgatagcc aagtgaccga agtgtgcgcc gccacctaca tgatgggcaa cgagctgacc      240

ttcctggacg acagcatctg taccggcacc agcagcggca atcaagtgaa cctgaccatc      300

cagggcctga gagccatgga taccggcctg tacatctgca aggtggaact gatgtaccct      360

ccgccttact acgaaggcat cggcaacggc acccagatct acgtgatcga ccctgagcct      420

tgtcctgaca gcgaccaaga gcctaagagc agcgacaaga cccacacaag ccctccatct      480

ccagctccag aactgctcgg cggcagctcc gtgtttctgt tccctccaaa gcctaaggac      540

accctgatga tcagcagaac ccctgaagtg acctgcgtgg tggtggatgt gtcccacgag      600

gatcccgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc      660

aagcctagag aggaacagta caacagcacc tacagagtgg tgtccgtgct gaccgtgctg      720

caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct      780

gctcctatcg agaaaaccat cagcaaggcc aagggccagc ctagggaacc ccaggtttac      840

acactgcctc caagccggga tgagctgacc aagaatcagg tgtccctgac ctgcctggtc      900

aagggcttct acccttccga tatcgccgtg gaatgggaga gcaatggcca gcctgagaac      960

aactacaaga ccacacctcc tgtgctggac agcgacggct cattcttcct gtacagcaag     1020

ctgacagtgg acaagagcag atggcagcag ggcaacgtgt tcagctgcag cgtgatgcac     1080

gaggccctgc acaaccacta cacccagaag tccctgtctc tgagccctgg caaataa        1137


<210> 36
<211> 174
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr 
145                 150                 155                 160 


Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
                165                 170                 


