                         SEQUENCE LISTING

<110>  KRIYA THERAPEUTICS, INC.
      
<120>  VECTOR CONSTRUCTS FOR DELIVERY OF NUCLEIC ACIDS ENCODING 
       THERAPEUTIC ANTI-TNF ANTIBODIES AND METHODS OF USING THE SAME

<130>  4525.030PC01

<150>  US 63/141,916
<151>  2021-01-26

<160>  161   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1

<400>  1

Asp Tyr Ala Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  2

Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  3

Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr 
1               5                   10          


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1

<400>  4

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2

<400>  5

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  6

Gln Arg Tyr Asn Arg Ala Pro Tyr Thr 
1               5                   


<210>  7
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH #1 adalimumab VH

<400>  7
gaggtgcagc tggtcgaaag cggcggaggg ctcgttcaac ccggtcggtc cttgagactt       60

tcttgcgccg cttcaggctt cacctttgac gattacgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtaagtgcc atcacatgga actcgggcca tattgactat      180

gctgatagcg tggaaggtcg cttcactata tcccgagaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg tgcagaggat acggccgtct attactgtgc taaggtgagt      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tcc                                                                    363


<210>  8
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH #2 Codon modified adalimumab VH

<400>  8
gaggtgcagc tggttgaaag cggcggaggg cttgttcaac ctggtagatc cttgagactt       60

tcttgcgccg cttcaggctt cacctttgat gattatgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtaagtgcc atcacatgga acagtggcca tattgactat      180

gctgatagtg tggaaggtag attcactata tcccgcgaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg cgcagaggat actgcggtct attactgtgc taaggtgagt      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tcc                                                                    363


<210>  9
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH #3 Codon modified adalimumab VH

<400>  9
gaggtgcagc tggttgaaag tggaggaggg cttgttcaac ctggtagatc cttgagactt       60

tcttgtgctg cttcaggctt cacctttgat gattatgcaa tgcactgggt gaggcaggca      120

cctggaaagg ggctggagtg ggtaagtgcc atcacatgga acagtggcca tattgactat      180

gctgatagtg tggaaggtag attcactata tccagagaca atgccaaaaa ctctttatac      240

ctgcagatga attcactaag ggcagaggat actgctgtct attactgtgc taaggtgagt      300

tatctcagca cagcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tct                                                                    363


<210>  10
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain Sequence

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  11
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL #1 adalimumab VL

<400>  11
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca       60

attacttgca gagcttcgca gggaataagg aactacctcg catggtatca gcaaaagcct      120

gggaaagcgc caaagttgct tatctacgcc gctagcacgc tgcagtccgg tgttccgtct      180

cgcttctcag gcagtggaag cgggaccgac tttacattaa ctatttcctc tctgcagccc      240

gaggatgtgg ccacctatta ctgtcagcga tataatcgtg caccttacac attcggccaa      300

ggtaccaaag tagaaatcaa g                                                321


<210>  12
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL #2 Codon modified adalimumab VL

<400>  12
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca       60

attacttgca gagcttccca gggaataagg aactacctcg cgtggtatca gcaaaagcct      120

gggaaagcgc caaagttgct tatctatgcc gctagcactc tgcagtcagg tgttccttct      180

agattctcag gcagtggaag cgggactgac tttacattaa ctatttcctc tctgcagcct      240

gaggatgtgg ccacctatta ctgtcagcgg tataatcgcg caccttacac atttggccaa      300

ggtaccaaag tagaaatcaa g                                                321


<210>  13
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL #3 Codon modified adalimumab VL

<400>  13
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tagagtcaca       60

attacttgca gagcttccca gggaataagg aactacttgg catggtatca gcaaaagcct      120

gggaaagctc caaagttgct tatctatgct gctagcactc tgcagtcagg tgttccttct      180

agattctcag gcagtggaag tgggactgac tttacattaa ctatttcctc tctgcagcct      240

gaggatgtgg ccacctatta ctgtcagagg tataatagag caccttacac atttggccaa      300

ggtaccaaag tagaaatcaa g                                                321


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain Sequence

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain Constant Region

<400>  15
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  16
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Constant Region

<400>  16
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  17
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain #1 Sequence

<400>  17
gaggtgcagc tggtcgaaag cggcggaggg ctcgttcaac ccggtcggtc cttgagactt       60

tcttgcgccg cttcaggctt cacctttgac gattacgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtaagtgcc atcacatgga actcgggcca tattgactat      180

gctgatagcg tggaaggtcg cttcactata tcccgagaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg tgcagaggat acggccgtct attactgtgc taaggtgagt      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaatga                               1356


<210>  18
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain #2 Sequence

<400>  18
gaggtgcagc tggttgaaag cggcggaggg cttgttcaac ctggtagatc cttgagactt       60

tcttgcgccg cttcaggctt cacctttgat gattatgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtaagtgcc atcacatgga acagtggcca tattgactat      180

gctgatagtg tggaaggtag attcactata tcccgcgaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg cgcagaggat actgcggtct attactgtgc taaggtgagt      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tccgcctcca ccaagggccc aagtgtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccctgaacc tgtgacagtg      480

tcttggaact caggcgccct gaccagcgga gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagtgtggtg actgtgccct ccagcagctt gggcacccag      600

acctacatct gcaatgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccttgcc cagcacctga actcctgggg      720

ggaccatcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccgcacc      780

cctgaggtca catgtgtggt ggtggatgtg agccatgaag accctgaggt caagttcaac      840

tggtatgtgg atggtgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacat acagagtggt ctctgtcctc actgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccattga gaaaaccatc     1020

tccaaagcca aagggcagcc cagggaacca caggtgtaca ccctgccccc atcccgcgat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagtgac     1140

attgctgtgg agtgggagag caatgggcag cctgagaaca actacaagac cacacctcca     1200

gtgctggact ctgatggctc cttcttcctc tacagcaagc tcactgtgga caagagcagg     1260

tggcagcagg ggaatgtctt ctcatgcagt gtgatgcatg aggctctgca caaccactac     1320

acacagaaga gcctctccct gtctcctggt aaatga                               1356


<210>  19
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain #3 Sequence

<400>  19
gaggtgcagc tggttgaaag tggaggaggg cttgttcaac ctggtagatc cttgagactt       60

tcttgtgctg cttcaggctt cacctttgat gattatgcaa tgcactgggt gaggcaggca      120

cctggaaagg ggctggagtg ggtaagtgcc atcacatgga acagtggcca tattgactat      180

gctgatagtg tggaaggtag attcactata tccagagaca atgccaaaaa ctctttatac      240

ctgcagatga attcactaag ggcagaggat actgctgtct attactgtgc taaggtgagt      300

tatctcagca cagcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tctgcctcca ccaagggccc aagtgtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cagccctggg ctgcctggtc aaggactact tccctgaacc tgtgactgtg      480

tcttggaact caggtgccct gaccagtgga gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag ctctgtggtg acagtgccct ccagcagctt gggcacccag      600

acctacatct gcaatgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccttgcc cagcacctga actcctgggg      720

ggaccatcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctccagaacc      780

cctgaggtca catgtgtggt ggtggatgtg agccatgaag accctgaggt caagttcaac      840

tggtatgtgg atggtgtgga ggtgcataat gccaagacaa agcctaggga ggagcagtac      900

aacagcactt acagagtggt cagtgtcctc acagtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccattga gaaaaccatc     1020

tccaaagcca aagggcagcc cagggaacca caggtgtaca ccctgccccc atccagagat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tccctcagac     1140

attgctgtgg agtgggagag caatgggcag ccagagaaca actacaagac cactcctcct     1200

gtgctggact ctgatggctc cttcttcctc tacagcaagc tcacagtgga caagagcagg     1260

tggcagcagg ggaatgtctt ctcatgcagt gtgatgcatg aggctctgca caaccactac     1320

actcagaaga gcctctccct gtctccaggt aaatga                               1356


<210>  20
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Sequence

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  21
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain #1

<400>  21
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca       60

attacttgca gagcttcgca gggaataagg aactacctcg catggtatca gcaaaagcct      120

gggaaagcgc caaagttgct tatctacgcc gctagcacgc tgcagtccgg tgttccgtct      180

cgcttctcag gcagtggaag cgggaccgac tttacattaa ctatttcctc tctgcagccc      240

gaggatgtgg ccacctatta ctgtcagcga tataatcgtg caccttacac attcggccaa      300

ggtaccaaag tagaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      645


<210>  22
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain #2

<400>  22
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca       60

attacttgca gagcttccca gggaataagg aactacctcg cgtggtatca gcaaaagcct      120

gggaaagcgc caaagttgct tatctatgcc gctagcactc tgcagtcagg tgttccttct      180

agattctcag gcagtggaag cgggactgac tttacattaa ctatttcctc tctgcagcct      240

gaggatgtgg ccacctatta ctgtcagcgg tataatcgcg caccttacac atttggccaa      300

ggtaccaaag tagaaatcaa gcggactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaaagtgg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      540

ctgagcaaag cagactatga gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc      600

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      645


<210>  23
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain #3

<400>  23
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tagagtcaca       60

attacttgca gagcttccca gggaataagg aactacttgg catggtatca gcaaaagcct      120

gggaaagctc caaagttgct tatctatgct gctagcactc tgcagtcagg tgttccttct      180

agattctcag gcagtggaag tgggactgac tttacattaa ctatttcctc tctgcagcct      240

gaggatgtgg ccacctatta ctgtcagagg tataatagag caccttacac atttggccaa      300

ggtaccaaag tagaaatcaa gaggactgtg gctgcaccat ctgtcttcat cttcccccca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaatcagg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      540

ctgagcaaag cagactatga gaaacacaaa gtctatgcct gtgaagtcac ccatcagggc      600

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      645


<210>  24
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain Sequence

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  25
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES

<400>  25
gcccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt      480

acacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg      540

gggacgtggt tttcctttga aaaacacgat gataatatgg ccaca                      585


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site

<400>  26
agaaagagaa ggagtggctc agga                                              24


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Wherein Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Wherein Xaa can be either Lys or Arg

<400>  27

Arg Xaa Xaa Arg 
1               


<210>  28
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A site

<400>  28
gcccctgtga aacagaccct gaactttgac ctcttgaagc ttgctgggga tgtggagtct       60

aatcctggtc ca                                                           72


<210>  29
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 leader

<400>  29
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg       60


<210>  30
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-10 leader

<400>  30
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggcc             54


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-142 binding site

<400>  31
tccataaagt aggaaacact aca                                               23


<210>  32
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4x miR-142 binding site

<400>  32
tccataaagt aggaaacact acactattcc ataaagtagg aaacactaca tcactccata       60

aagtaggaaa cactacaagt ctccataaag taggaaacac taca                       104


<210>  33
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 intron

<400>  33
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  34
<211>  230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF-1(alpha)

<400>  34
gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg       60

gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg      120

atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag      180

tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag                 230


<210>  35
<211>  380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV enhancer

<400>  35
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  36
<211>  218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMVp

<400>  36
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agctcgttta gtgaaccg                              218


<210>  37
<211>  598
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV ehancer and promoter (CMVe/p)

<400>  37
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccg        598


<210>  38
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG

<400>  38
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaa                     1725


<210>  39
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic poly(A)

<400>  39
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210>  40
<211>  224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGH poly(A)

<400>  40
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatg                       224


<210>  41
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pause element

<400>  41
aacatacgct ctccatcaaa acaaaacgaa acaaaacaaa ctagcaaaat aggctgtccc       60

cagtgcaagt gcaggtgcca gaacatttct ct                                     92


<210>  42
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #1

<400>  42
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca      120

attacttgca gagcttcgca gggaataagg aactacctcg catggtatca gcaaaagcct      180

gggaaagcgc caaagttgct tatctacgcc gctagcacgc tgcagtccgg tgttccgtct      240

cgcttctcag gcagtggaag cgggaccgac tttacattaa ctatttcctc tctgcagccc      300

gaggatgtgg ccacctatta ctgtcagcga tataatcgtg caccttacac attcggccaa      360

ggtaccaaag tagaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  43
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #2

<400>  43
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactca       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca      120

attacttgca gagcttccca gggaataagg aactacctcg cgtggtatca gcaaaagcct      180

gggaaagcgc caaagttgct tatctatgcc gctagcactc tgcagtcagg tgttccttct      240

agattctcag gcagtggaag cgggactgac tttacattaa ctatttcctc tctgcagcct      300

gaggatgtgg ccacctatta ctgtcagcgg tataatcgcg caccttacac atttggccaa      360

ggtaccaaag tagaaatcaa gcggactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaaagtgg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      600

ctgagcaaag cagactatga gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc      660

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  44
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #3

<400>  44
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactca       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tagagtcaca      120

attacttgca gagcttccca gggaataagg aactacttgg catggtatca gcaaaagcct      180

gggaaagctc caaagttgct tatctatgct gctagcactc tgcagtcagg tgttccttct      240

agattctcag gcagtggaag tgggactgac tttacattaa ctatttcctc tctgcagcct      300

gaggatgtgg ccacctatta ctgtcagagg tataatagag caccttacac atttggccaa      360

ggtaccaaag tagaaatcaa gaggactgtg gctgcaccat ctgtcttcat cttcccccca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaatcagg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      600

ctgagcaaag cagactatga gaaacacaaa gtctatgcct gtgaagtcac ccatcagggc      660

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  45
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #4

<400>  45
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca      120

attacttgca gagcttcgca gggaataagg aactacctcg catggtatca gcaaaagcct      180

gggaaagcgc caaagttgct tatctacgcc gccagcacgc tgcagtccgg tgttccgtct      240

cgcttctctg gcagtggaag cgggaccgac tttacattaa ctatttcctc tctgcaaccc      300

gaggatgtgg ccacctatta ctgtcagcga tataatcgtg caccttacac attcggccaa      360

ggtaccaaag tagaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg caactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  46
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #5

<400>  46
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactca       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca      120

attacttgca gagcttccca gggaataagg aactacctcg cgtggtatca gcaaaagcct      180

gggaaagcgc caaagttgct tatctatgcc gccagcactc tgcagtcagg tgttcctagt      240

agattctctg gcagtggaag cgggactgac tttacattaa ctatttcctc tctgcaacct      300

gaggatgtgg ccacctatta ctgtcagcgg tataatcgcg caccttacac atttggccaa      360

ggtaccaaag tagaaatcaa gcggactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaaagtgg caactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      600

ctgagcaaag cagactatga gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc      660

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  47
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #6

<400>  47
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactca       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tagagtcaca      120

attacttgca gagcttccca gggaataagg aactacttgg catggtatca gcaaaagcct      180

gggaaagctc caaagttgct tatctatgct gccagcactc tgcagtcagg tgttcctagt      240

agattctcag gcagtggaag tgggactgac tttacattaa ctatttcctc tctgcaacct      300

gaggatgtgg ccacctatta ctgtcagagg tataatagag caccttacac atttggccaa      360

ggtaccaaag tagaaatcaa gaggactgtg gctgcaccat ctgtcttcat cttcccccca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaatcagg caactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      600

ctgagcaaag cagactatga gaaacacaaa gtctatgcct gtgaagtcac ccatcagggc      660

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  48
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #7

<400>  48
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca      120

attacttgca gagcttcgca gggaataagg aactacctcg catggtatca gcaaaagcct      180

gggaaagcgc caaagttgct tatctacgcc gccagcacgc tgcagtccgg tgttccgtct      240

cgcttctctg gcagtggaag cgggaccgac tttacattaa ctatttcctc tctgcaaccc      300

gaggatgtgg ccacctatta ctgtcagcga tataatcgtg caccttacac attcggccaa      360

ggtaccaaag tagaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg caactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  49
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #8

<400>  49
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactca       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca      120

attacttgca gagcttccca gggaataagg aactacctcg cgtggtatca gcaaaagcct      180

gggaaagcgc caaagttgct tatctatgcc gccagcactc tgcagtcagg tgttcctagt      240

agattctctg gcagtggaag cgggactgac tttacattaa ctatttcctc tctgcaacct      300

gaggatgtgg ccacctatta ctgtcagcgg tataatcgcg caccttacac atttggccaa      360

ggtaccaaag tagaaatcaa gcggactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaaagtgg caactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      600

ctgagcaaag cagactatga gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc      660

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  50
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #9

<400>  50
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactca       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tagagtcaca      120

attacttgca gagcttccca gggaataagg aactacttgg catggtatca gcaaaagcct      180

gggaaagctc caaagttgct tatctatgct gccagcactc tgcagtcagg tgttcctagt      240

agattctcag gcagtggaag tgggactgac tttacattaa ctatttcctc tctgcaacct      300

gaggatgtgg ccacctatta ctgtcagagg tataatagag caccttacac atttggccaa      360

ggtaccaaag tagaaatcaa gaggactgtg gctgcaccat ctgtcttcat cttcccccca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaatcagg caactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      600

ctgagcaaag cagactatga gaaacacaaa gtctatgcct gtgaagtcac ccatcagggc      660

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  51
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC ORF #10

<400>  51
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg       60

gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca      120

attacttgca gagcttcgca gggaataagg aactacctcg catggtatca gcaaaagcct      180

gggaaagcgc caaagttgct tatctacgcc gccagcacgc tgcagtccgg tgttccgtct      240

cgcttctctg gcagtggaag cgggaccgac tttacattaa ctatttcctc tctgcaaccc      300

gaggatgtgg ccacctatta ctgtcagcga tataatcgtg caccttacac attcggccaa      360

ggtaccaaag tagaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg caactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      705


<210>  52
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #1

<400>  52
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggccgaggtg       60

cagctggtcg aaagcggcgg agggctcgtt caacccggtc ggtccttgag actttcttgc      120

gccgcttcag gcttcacctt tgacgattac gcaatgcact gggtgaggca ggcgcctgga      180

aaggggctgg agtgggtaag tgccatcaca tggaactcgg gccatattga ctatgctgat      240

agcgtggaag gtcgcttcac tatatcccga gacaatgcca aaaactcttt atacctgcag      300

atgaattcac tacgtgcaga ggatacggcc gtctattact gtgctaaggt gagttatctc      360

agcaccgcat cctctctgga ctactgggga caagggacat tggttactgt gagctccgcc      420

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1080

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1260

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1380

aagagcctct ccctgtctcc gggtaaatga                                      1410


<210>  53
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #2

<400>  53
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggctgaggtg       60

cagctggttg aaagcggcgg agggcttgtt caacctggta gatccttgag actttcttgc      120

gccgcttcag gcttcacctt tgatgattat gcaatgcact gggtgaggca ggcgcctgga      180

aaggggctgg agtgggtaag tgccatcaca tggaacagtg gccatattga ctatgctgat      240

agtgtggaag gtagattcac tatatcccgc gacaatgcca aaaactcttt atacctgcag      300

atgaattcac tacgcgcaga ggatactgcg gtctattact gtgctaaggt gagttatctc      360

agcaccgcat cctctctgga ctactgggga caagggacat tggttactgt gagctccgcc      420

tccaccaagg gcccaagtgt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccctg aacctgtgac agtgtcttgg      540

aactcaggcg ccctgaccag cggagtgcac accttcccag ctgtcctaca gtcctcagga      600

ctctactccc tcagcagtgt ggtgactgtg ccctccagca gcttgggcac ccagacctac      660

atctgcaatg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccacct tgcccagcac ctgaactcct ggggggacca      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg cacccctgag      840

gtcacatgtg tggtggtgga tgtgagccat gaagaccctg aggtcaagtt caactggtat      900

gtggatggtg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      960

acatacagag tggtctctgt cctcactgtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccca ttgagaaaac catctccaaa     1080

gccaaagggc agcccaggga accacaggtg tacaccctgc ccccatcccg cgatgagctg     1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag tgacattgct     1200

gtggagtggg agagcaatgg gcagcctgag aacaactaca agaccacacc tccagtgctg     1260

gactctgatg gctccttctt cctctacagc aagctcactg tggacaagag caggtggcag     1320

caggggaatg tcttctcatg cagtgtgatg catgaggctc tgcacaacca ctacacacag     1380

aagagcctct ccctgtctcc tggtaaatga                                      1410


<210>  54
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #3

<400>  54
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggctgaggtg       60

cagctggttg aaagtggagg agggcttgtt caacctggta gatccttgag actttcttgt      120

gctgcttcag gcttcacctt tgatgattat gcaatgcact gggtgaggca ggcacctgga      180

aaggggctgg agtgggtaag tgccatcaca tggaacagtg gccatattga ctatgctgat      240

agtgtggaag gtagattcac tatatccaga gacaatgcca aaaactcttt atacctgcag      300

atgaattcac taagggcaga ggatactgct gtctattact gtgctaaggt gagttatctc      360

agcacagcat cctctctgga ctactgggga caagggacat tggttactgt gagctctgcc      420

tccaccaagg gcccaagtgt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcagccc tgggctgcct ggtcaaggac tacttccctg aacctgtgac tgtgtcttgg      540

aactcaggtg ccctgaccag tggagtgcac accttcccag ctgtcctaca gtcctcagga      600

ctctactccc tcagctctgt ggtgacagtg ccctccagca gcttgggcac ccagacctac      660

atctgcaatg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccacct tgcccagcac ctgaactcct ggggggacca      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctccag aacccctgag      840

gtcacatgtg tggtggtgga tgtgagccat gaagaccctg aggtcaagtt caactggtat      900

gtggatggtg tggaggtgca taatgccaag acaaagccta gggaggagca gtacaacagc      960

acttacagag tggtcagtgt cctcacagtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccca ttgagaaaac catctccaaa     1080

gccaaagggc agcccaggga accacaggtg tacaccctgc ccccatccag agatgagctg     1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatccctc agacattgct     1200

gtggagtggg agagcaatgg gcagccagag aacaactaca agaccactcc tcctgtgctg     1260

gactctgatg gctccttctt cctctacagc aagctcacag tggacaagag caggtggcag     1320

caggggaatg tcttctcatg cagtgtgatg catgaggctc tgcacaacca ctacactcag     1380

aagagcctct ccctgtctcc aggtaaatga                                      1410


<210>  55
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #4

<400>  55
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggccgaggtg       60

cagctggtcg aaagcggcgg agggctcgtt caacccggtc ggtccttgag actttcttgc      120

gccgcttctg gcttcacctt tgacgattac gcaatgcact gggtgaggca ggcgcctgga      180

aaggggctgg agtgggtatc agccatcaca tggaactcgg gccatattga ctatgctgat      240

agcgtggaag gtcgcttcac tatatcccga gacaatgcca aaaactcttt atacctgcag      300

atgaattcac tacgtgcaga ggatacggcc gtctattact gtgctaaggt gtcatatctc      360

agcaccgcat cctctctgga ctactgggga caagggacat tggttactgt gagctccgcc      420

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccta tcgagaaaac aatctccaaa     1080

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1140

accaagaacc aagtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1260

gactccgacg gctccttctt cctctactcc aagctcaccg tggacaagag caggtggcag     1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1380

aagagcctct ccctgtctcc gggtaaa                                         1407


<210>  56
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #5

<400>  56
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggctgaggtg       60

cagctggttg aaagcggcgg agggcttgtt caacctggta gatccttgag actttcttgc      120

gccgcttctg gcttcacctt tgatgattat gcaatgcact gggtgaggca ggcgcctgga      180

aaggggctgg agtgggtatc agccatcaca tggaacagtg gccatattga ctatgctgat      240

agtgtggaag gtagattcac tatatcccgc gacaatgcca aaaactcttt atacctgcag      300

atgaattcac tacgcgcaga ggatactgcg gtctattact gtgctaaggt gtcatatctc      360

agcaccgcat cctctctgga ctactgggga caagggacat tggttactgt gagctccgcc      420

tccaccaagg gcccaagtgt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccctg aacctgtgac agtgtcttgg      540

aactcaggcg ccctgaccag cggagtgcac accttcccag ctgtcctaca gtcctcagga      600

ctctactccc tcagcagtgt ggtgactgtg ccctccagca gcttgggcac ccagacctac      660

atctgcaatg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccacct tgcccagcac ctgaactcct ggggggacca      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg cacccctgag      840

gtcacatgtg tggtggtgga tgtgagccat gaagaccctg aggtcaagtt caactggtat      900

gtggatggtg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      960

acatacagag tggtctctgt cctcactgtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccta ttgagaaaac aatctccaaa     1080

gccaaagggc agcccaggga accacaggtg tacaccctgc ccccatcccg cgatgagctg     1140

accaagaacc aggtctccct gacctgcctg gtcaaaggct tctatcccag tgacattgct     1200

gtggagtggg agagcaatgg gcagcctgag aacaactaca agaccacacc tccagtgctg     1260

gactctgatg gctccttctt cctctactcc aagctcactg tggacaagag caggtggcag     1320

caggggaatg tcttctcatg cagtgtgatg catgaggctc tgcacaacca ctacacacag     1380

aagagcctct ccctgtctcc tggtaaa                                         1407


<210>  57
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #6

<400>  57
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggctgaggtg       60

cagctggttg aaagtggagg agggcttgtt caacctggta gatccttgag actttcttgt      120

gctgcttctg gcttcacctt tgatgattat gcaatgcact gggtgaggca ggcacctgga      180

aaggggctgg agtgggtatc agccatcaca tggaacagtg gccatattga ctatgctgat      240

agtgtggaag gtagattcac tatatccaga gacaatgcca aaaactcttt atacctgcag      300

atgaattcac taagggcaga ggatactgct gtctattact gtgctaaggt atcatatctc      360

agcacagcat cctctctgga ctactgggga caagggacat tggttactgt gagctctgcc      420

tccaccaagg gcccaagtgt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcagccc tgggctgcct ggtcaaggac tacttccctg aacctgtgac tgtgtcttgg      540

aactcaggtg ccctgaccag tggagtgcac accttcccag ctgtcctaca gtcctcagga      600

ctctactccc tgagctctgt ggtgacagtg ccctccagca gcttgggcac ccagacctac      660

atctgcaatg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccacct tgcccagcac ctgaactcct ggggggacca      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctccag aacccctgag      840

gtcacatgtg tggtggtgga tgtgagccat gaagaccctg aggtcaagtt caactggtat      900

gtggatggtg tggaggtgca taatgccaag acaaagccca gggaggagca gtacaacagc      960

acttacagag tggtcagtgt cctcacagtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccca ttgagaaaac catctccaaa     1080

gccaaagggc agcccaggga accacaggtg tacaccctgc ccccatccag agatgagctg     1140

accaagaacc aggtctccct gacctgcctg gtcaaaggct tctatccctc tgacattgct     1200

gtggagtggg agagcaatgg gcagccagag aacaactaca agaccactcc tcctgtgctg     1260

gactctgatg gctccttctt cctctactcc aagctcacag tggacaagag caggtggcag     1320

caggggaatg tcttctcatg cagtgtgatg catgaggctc tgcacaacca ctacactcag     1380

aagagcctct ccctgtctcc tggcaaa                                         1407


<210>  58
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #7

<400>  58
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggccgaggtg       60

cagctggtcg aaagcggcgg agggctcgtt caacccggtc ggtccttgag actttcttgc      120

gccgcttctg gcttcacctt tgacgattac gcaatgcact gggtgaggca ggcgcctgga      180

aaggggctgg agtgggtatc agccatcaca tggaactcgg gccatattga ctatgctgat      240

agcgtggaag gtcgcttcac tatatcccga gacaatgcca aaaactcttt atacctgcag      300

atgaattcac tacgtgcaga ggatacggcc gtctattact gtgctaaggt gtcatatctc      360

agcaccgcat cctctctgga ctactgggga caagggacat tggttactgt gagctccgcc      420

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccta tcgagaaaac aatctccaaa     1080

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1140

accaagaacc aagtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1260

gactccgacg gctccttctt cctctactcc aagctcaccg tggacaagag caggtggcag     1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1380

aagagcctct ccctgtctcc gggcaaa                                         1407


<210>  59
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #8

<400>  59
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggctgaggtg       60

cagctggttg aaagcggcgg agggcttgtt caacctggta gatccttgag actttcttgc      120

gccgcttctg gcttcacctt tgatgattat gcaatgcact gggtgaggca ggcgcctgga      180

aaggggctgg agtgggtatc agccatcaca tggaacagtg gccatattga ctatgctgat      240

agtgtggaag gtagattcac tatatcccgc gacaatgcca aaaactcttt atacctgcag      300

atgaattcac tacgcgcaga ggatactgcg gtctattact gtgctaaggt gtcatatctc      360

agcaccgcat cctctctgga ctactgggga caagggacat tggttactgt gagctccgcc      420

tccaccaagg gcccaagtgt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccctg aacctgtgac agtgtcttgg      540

aactcaggcg ccctgaccag cggagtgcac accttcccag ctgtcctaca gtcctcagga      600

ctctactccc tcagcagtgt ggtgactgtg ccctccagca gcttgggcac ccagacctac      660

atctgcaatg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccacct tgcccagcac ctgaactcct ggggggacca      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg cacccctgag      840

gtcacatgtg tggtggtgga tgtgagccat gaagaccctg aggtcaagtt caactggtat      900

gtggatggtg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      960

acatacagag tggtctctgt cctcactgtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccta ttgagaaaac aatctccaaa     1080

gccaaagggc agcccaggga accacaggtg tacaccctgc ccccatcccg cgatgagctg     1140

accaagaacc aggtctccct gacctgcctg gtcaaaggct tctatcccag tgacattgct     1200

gtggagtggg agagcaatgg gcagcctgag aacaactaca agaccacacc tccagtgctg     1260

gactctgatg gctccttctt cctctactcc aagctcactg tggacaagag caggtggcag     1320

caggggaatg tcttctcatg cagtgtgatg catgaggctc tgcacaacca ctacacacag     1380

aagagcctct ccctgtctcc tggcaaa                                         1407


<210>  60
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #9

<400>  60
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggctgaggtg       60

cagctggttg aaagtggagg agggcttgtt caacctggta gatccttgag actttcttgt      120

gctgcttctg gcttcacctt tgatgattat gcaatgcact gggtgaggca ggcacctgga      180

aaggggctgg agtgggtatc agccatcaca tggaacagtg gccatattga ctatgctgat      240

agtgtggaag gtagattcac tatatccaga gacaatgcca aaaactcttt atacctgcag      300

atgaattcac taagggcaga ggatactgct gtctattact gtgctaaggt atcatatctc      360

agcacagcat cctctctgga ctactgggga caagggacat tggttactgt gagctctgcc      420

tccaccaagg gcccaagtgt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcagccc tgggctgcct ggtcaaggac tacttccctg aacctgtgac tgtgtcttgg      540

aactcaggtg ccctgaccag tggagtgcac accttcccag ctgtcctaca gtcctcagga      600

ctctactccc tgagctctgt ggtgacagtg ccctccagca gcttgggcac ccagacctac      660

atctgcaatg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccacct tgcccagcac ctgaactcct ggggggacca      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctccag aacccctgag      840

gtcacatgtg tggtggtgga tgtgagccat gaagaccctg aggtcaagtt caactggtat      900

gtggatggtg tggaggtgca taatgccaag acaaagccca gggaggagca gtacaacagc      960

acttacagag tggtcagtgt cctcacagtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccca ttgagaaaac catctccaaa     1080

gccaaagggc agcccaggga accacaggtg tacaccctgc ccccatccag agatgagctg     1140

accaagaacc aggtctccct gacctgcctg gtcaaaggct tctatccctc tgacattgct     1200

gtggagtggg agagcaatgg gcagccagag aacaactaca agaccactcc tcctgtgctg     1260

gactctgatg gctccttctt cctctactcc aagctcacag tggacaagag caggtggcag     1320

caggggaatg tcttctcatg cagtgtgatg catgaggctc tgcacaacca ctacactcag     1380

aagagcctct ccctgtctcc tggcaaa                                         1407


<210>  61
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC ORF #10

<400>  61
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggccgaggtg       60

cagctggtcg aaagcggcgg agggctcgtt caacccggtc ggtccttgag actttcttgc      120

gccgcttctg gcttcacctt tgacgattac gcaatgcact gggtgaggca ggcgcctgga      180

aaggggctgg agtgggtatc agccatcaca tggaactcgg gccatattga ctatgctgat      240

agcgtggaag gtcgcttcac tatatcccga gacaatgcca aaaactcttt atacctgcag      300

atgaattcac tacgtgcaga ggatacggcc gtctattact gtgctaaggt gtcatatctc      360

agcaccgcat cctctctgga ctactgggga caagggacat tggttactgt gagctccgcc      420

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      720

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccta tcgagaaaac aatctccaaa     1080

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1140

accaagaacc aagtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1260

gactccgacg gctccttctt cctctactcc aagctcaccg tggacaagag caggtggcag     1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1380

aagagcctct ccctgtctcc gggcaaa                                         1407


<210>  62
<211>  4485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #1 H-F2A-L (including ITRs)

<400>  62
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc cgaggtgcag ctggtcgaaa gcggcggagg     1980

gctcgttcaa cccggtcggt ccttgagact ttcttgcgcc gcttctggct tcacctttga     2040

cgattacgca atgcactggg tgaggcaggc gcctggaaag gggctggagt gggtatcagc     2100

catcacatgg aactcgggcc atattgacta tgctgatagc gtggaaggtc gcttcactat     2160

atcccgagac aatgccaaaa actctttata cctgcagatg aattcactac gtgcagagga     2220

tacggccgtc tattactgtg ctaaggtgtc atatctcagc accgcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctccgcctcc accaagggcc catcggtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     2400

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     2460

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2520

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2760

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2820

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2880

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccctatcg agaaaacaat ctccaaagcc aaagggcagc cccgagaacc     3000

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccaag tcagcctgac     3060

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     3120

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     3180

ctactccaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     3240

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     3300

taaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca attacttgca gagcttcgca     3540

gggaataagg aactacctcg catggtatca gcaaaagcct gggaaagcgc caaagttgct     3600

tatctacgcc gccagcacgc tgcagtccgg tgttccgtct cgcttctctg gcagtggaag     3660

cgggaccgac tttacattaa ctatttcctc tctgcaaccc gaggatgtgg ccacctatta     3720

ctgtcagcga tataatcgtg caccttacac attcggccaa ggtaccaaag tagaaatcaa     3780

gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataacgccc tccaatcggg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga     4020

gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa     4080

gagcttcaac aggggagagt gttgacaatt gctgtgcctt ctagttgcca gccatctgtt     4140

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     4200

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     4260

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     4320

gcggtgggct ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc     4380

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4440

cccgggcggc ctcagtgagc gagcgagcgc gcagctgcag atctg                     4485


<210>  63
<211>  4595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #2 H-F2A-L-4xmiR142 (including ITRs)

<400>  63
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc cgaggtgcag ctggtcgaaa gcggcggagg     1980

gctcgttcaa cccggtcggt ccttgagact ttcttgcgcc gcttctggct tcacctttga     2040

cgattacgca atgcactggg tgaggcaggc gcctggaaag gggctggagt gggtatcagc     2100

catcacatgg aactcgggcc atattgacta tgctgatagc gtggaaggtc gcttcactat     2160

atcccgagac aatgccaaaa actctttata cctgcagatg aattcactac gtgcagagga     2220

tacggccgtc tattactgtg ctaaggtgtc atatctcagc accgcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctccgcctcc accaagggcc catcggtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     2400

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     2460

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2520

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2760

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2820

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2880

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccctatcg agaaaacaat ctccaaagcc aaagggcagc cccgagaacc     3000

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccaag tcagcctgac     3060

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     3120

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     3180

ctactccaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     3240

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     3300

taaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca attacttgca gagcttcgca     3540

gggaataagg aactacctcg catggtatca gcaaaagcct gggaaagcgc caaagttgct     3600

tatctacgcc gccagcacgc tgcagtccgg tgttccgtct cgcttctctg gcagtggaag     3660

cgggaccgac tttacattaa ctatttcctc tctgcaaccc gaggatgtgg ccacctatta     3720

ctgtcagcga tataatcgtg caccttacac attcggccaa ggtaccaaag tagaaatcaa     3780

gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataacgccc tccaatcggg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga     4020

gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa     4080

gagcttcaac aggggagagt gttgacctag gtccataaag taggaaacac tacactattc     4140

cataaagtag gaaacactac atcactccat aaagtaggaa acactacaag tctccataaa     4200

gtaggaaaca ctacacaatt gctgtgcctt ctagttgcca gccatctgtt gtttgcccct     4260

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     4320

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     4380

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     4440

ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4500

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4560

ctcagtgagc gagcgagcgc gcagctgcag atctg                                4595


<210>  64
<211>  4485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #3 H-F2A-L (including ITRs)

<400>  64
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc tgaggtgcag ctggttgaaa gcggcggagg     1980

gcttgttcaa cctggtagat ccttgagact ttcttgcgcc gcttctggct tcacctttga     2040

tgattatgca atgcactggg tgaggcaggc gcctggaaag gggctggagt gggtatcagc     2100

catcacatgg aacagtggcc atattgacta tgctgatagt gtggaaggta gattcactat     2160

atcccgcgac aatgccaaaa actctttata cctgcagatg aattcactac gcgcagagga     2220

tactgcggtc tattactgtg ctaaggtgtc atatctcagc accgcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctccgcctcc accaagggcc caagtgtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     2400

caaggactac ttccctgaac ctgtgacagt gtcttggaac tcaggcgccc tgaccagcgg     2460

agtgcacacc ttcccagctg tcctacagtc ctcaggactc tactccctca gcagtgtggt     2520

gactgtgccc tccagcagct tgggcaccca gacctacatc tgcaatgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccttgc ccagcacctg aactcctggg gggaccatca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctcccgcac ccctgaggtc acatgtgtgg tggtggatgt     2760

gagccatgaa gaccctgagg tcaagttcaa ctggtatgtg gatggtgtgg aggtgcataa     2820

tgccaagaca aagccgcggg aggagcagta caacagcaca tacagagtgg tctctgtcct     2880

cactgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccctattg agaaaacaat ctccaaagcc aaagggcagc ccagggaacc     3000

acaggtgtac accctgcccc catcccgcga tgagctgacc aagaaccagg tctccctgac     3060

ctgcctggtc aaaggcttct atcccagtga cattgctgtg gagtgggaga gcaatgggca     3120

gcctgagaac aactacaaga ccacacctcc agtgctggac tctgatggct ccttcttcct     3180

ctactccaag ctcactgtgg acaagagcag gtggcagcag gggaatgtct tctcatgcag     3240

tgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc tgtctcctgg     3300

taaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactca gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca attacttgca gagcttccca     3540

gggaataagg aactacctcg cgtggtatca gcaaaagcct gggaaagcgc caaagttgct     3600

tatctatgcc gccagcactc tgcagtcagg tgttcctagt agattctctg gcagtggaag     3660

cgggactgac tttacattaa ctatttcctc tctgcaacct gaggatgtgg ccacctatta     3720

ctgtcagcgg tataatcgcg caccttacac atttggccaa ggtaccaaag tagaaatcaa     3780

gcggactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataatgccc tccaaagtgg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacc ctgagcaaag cagactatga     4020

gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc ctgagctccc cagtcacaaa     4080

gagcttcaac aggggagagt gttgacaatt gctgtgcctt ctagttgcca gccatctgtt     4140

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     4200

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     4260

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     4320

gcggtgggct ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc     4380

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4440

cccgggcggc ctcagtgagc gagcgagcgc gcagctgcag atctg                     4485


<210>  65
<211>  4595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #4 H-F2A-L-4xmiR142 (including ITRs)

<400>  65
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc tgaggtgcag ctggttgaaa gcggcggagg     1980

gcttgttcaa cctggtagat ccttgagact ttcttgcgcc gcttctggct tcacctttga     2040

tgattatgca atgcactggg tgaggcaggc gcctggaaag gggctggagt gggtatcagc     2100

catcacatgg aacagtggcc atattgacta tgctgatagt gtggaaggta gattcactat     2160

atcccgcgac aatgccaaaa actctttata cctgcagatg aattcactac gcgcagagga     2220

tactgcggtc tattactgtg ctaaggtgtc atatctcagc accgcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctccgcctcc accaagggcc caagtgtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     2400

caaggactac ttccctgaac ctgtgacagt gtcttggaac tcaggcgccc tgaccagcgg     2460

agtgcacacc ttcccagctg tcctacagtc ctcaggactc tactccctca gcagtgtggt     2520

gactgtgccc tccagcagct tgggcaccca gacctacatc tgcaatgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccttgc ccagcacctg aactcctggg gggaccatca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctcccgcac ccctgaggtc acatgtgtgg tggtggatgt     2760

gagccatgaa gaccctgagg tcaagttcaa ctggtatgtg gatggtgtgg aggtgcataa     2820

tgccaagaca aagccgcggg aggagcagta caacagcaca tacagagtgg tctctgtcct     2880

cactgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccctattg agaaaacaat ctccaaagcc aaagggcagc ccagggaacc     3000

acaggtgtac accctgcccc catcccgcga tgagctgacc aagaaccagg tctccctgac     3060

ctgcctggtc aaaggcttct atcccagtga cattgctgtg gagtgggaga gcaatgggca     3120

gcctgagaac aactacaaga ccacacctcc agtgctggac tctgatggct ccttcttcct     3180

ctactccaag ctcactgtgg acaagagcag gtggcagcag gggaatgtct tctcatgcag     3240

tgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc tgtctcctgg     3300

taaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactca gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca attacttgca gagcttccca     3540

gggaataagg aactacctcg cgtggtatca gcaaaagcct gggaaagcgc caaagttgct     3600

tatctatgcc gccagcactc tgcagtcagg tgttcctagt agattctctg gcagtggaag     3660

cgggactgac tttacattaa ctatttcctc tctgcaacct gaggatgtgg ccacctatta     3720

ctgtcagcgg tataatcgcg caccttacac atttggccaa ggtaccaaag tagaaatcaa     3780

gcggactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataatgccc tccaaagtgg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacc ctgagcaaag cagactatga     4020

gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc ctgagctccc cagtcacaaa     4080

gagcttcaac aggggagagt gttgacctag gtccataaag taggaaacac tacactattc     4140

cataaagtag gaaacactac atcactccat aaagtaggaa acactacaag tctccataaa     4200

gtaggaaaca ctacacaatt gctgtgcctt ctagttgcca gccatctgtt gtttgcccct     4260

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     4320

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     4380

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     4440

ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4500

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4560

ctcagtgagc gagcgagcgc gcagctgcag atctg                                4595


<210>  66
<211>  4485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #5 H-F2A-L (including ITRs)

<400>  66
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc tgaggtgcag ctggttgaaa gtggaggagg     1980

gcttgttcaa cctggtagat ccttgagact ttcttgtgct gcttctggct tcacctttga     2040

tgattatgca atgcactggg tgaggcaggc acctggaaag gggctggagt gggtatcagc     2100

catcacatgg aacagtggcc atattgacta tgctgatagt gtggaaggta gattcactat     2160

atccagagac aatgccaaaa actctttata cctgcagatg aattcactaa gggcagagga     2220

tactgctgtc tattactgtg ctaaggtatc atatctcagc acagcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctctgcctcc accaagggcc caagtgtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcagccctgg gctgcctggt     2400

caaggactac ttccctgaac ctgtgactgt gtcttggaac tcaggtgccc tgaccagtgg     2460

agtgcacacc ttcccagctg tcctacagtc ctcaggactc tactccctga gctctgtggt     2520

gacagtgccc tccagcagct tgggcaccca gacctacatc tgcaatgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccttgc ccagcacctg aactcctggg gggaccatca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctccagaac ccctgaggtc acatgtgtgg tggtggatgt     2760

gagccatgaa gaccctgagg tcaagttcaa ctggtatgtg gatggtgtgg aggtgcataa     2820

tgccaagaca aagcccaggg aggagcagta caacagcact tacagagtgg tcagtgtcct     2880

cacagtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccccattg agaaaaccat ctccaaagcc aaagggcagc ccagggaacc     3000

acaggtgtac accctgcccc catccagaga tgagctgacc aagaaccagg tctccctgac     3060

ctgcctggtc aaaggcttct atccctctga cattgctgtg gagtgggaga gcaatgggca     3120

gccagagaac aactacaaga ccactcctcc tgtgctggac tctgatggct ccttcttcct     3180

ctactccaag ctcacagtgg acaagagcag gtggcagcag gggaatgtct tctcatgcag     3240

tgtgatgcat gaggctctgc acaaccacta cactcagaag agcctctccc tgtctcctgg     3300

caaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactca gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtggggga tagagtcaca attacttgca gagcttccca     3540

gggaataagg aactacttgg catggtatca gcaaaagcct gggaaagctc caaagttgct     3600

tatctatgct gccagcactc tgcagtcagg tgttcctagt agattctcag gcagtggaag     3660

tgggactgac tttacattaa ctatttcctc tctgcaacct gaggatgtgg ccacctatta     3720

ctgtcagagg tataatagag caccttacac atttggccaa ggtaccaaag tagaaatcaa     3780

gaggactgtg gctgcaccat ctgtcttcat cttcccccca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataatgccc tccaatcagg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacc ctgagcaaag cagactatga     4020

gaaacacaaa gtctatgcct gtgaagtcac ccatcagggc ctgagctccc cagtcacaaa     4080

gagcttcaac aggggagagt gttgacaatt gctgtgcctt ctagttgcca gccatctgtt     4140

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     4200

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     4260

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     4320

gcggtgggct ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc     4380

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4440

cccgggcggc ctcagtgagc gagcgagcgc gcagctgcag atctg                     4485


<210>  67
<211>  4595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #6 H-F2A-L-4xmiR142 (including ITRs)

<400>  67
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc tgaggtgcag ctggttgaaa gtggaggagg     1980

gcttgttcaa cctggtagat ccttgagact ttcttgtgct gcttctggct tcacctttga     2040

tgattatgca atgcactggg tgaggcaggc acctggaaag gggctggagt gggtatcagc     2100

catcacatgg aacagtggcc atattgacta tgctgatagt gtggaaggta gattcactat     2160

atccagagac aatgccaaaa actctttata cctgcagatg aattcactaa gggcagagga     2220

tactgctgtc tattactgtg ctaaggtatc atatctcagc acagcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctctgcctcc accaagggcc caagtgtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcagccctgg gctgcctggt     2400

caaggactac ttccctgaac ctgtgactgt gtcttggaac tcaggtgccc tgaccagtgg     2460

agtgcacacc ttcccagctg tcctacagtc ctcaggactc tactccctga gctctgtggt     2520

gacagtgccc tccagcagct tgggcaccca gacctacatc tgcaatgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccttgc ccagcacctg aactcctggg gggaccatca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctccagaac ccctgaggtc acatgtgtgg tggtggatgt     2760

gagccatgaa gaccctgagg tcaagttcaa ctggtatgtg gatggtgtgg aggtgcataa     2820

tgccaagaca aagcccaggg aggagcagta caacagcact tacagagtgg tcagtgtcct     2880

cacagtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccccattg agaaaaccat ctccaaagcc aaagggcagc ccagggaacc     3000

acaggtgtac accctgcccc catccagaga tgagctgacc aagaaccagg tctccctgac     3060

ctgcctggtc aaaggcttct atccctctga cattgctgtg gagtgggaga gcaatgggca     3120

gccagagaac aactacaaga ccactcctcc tgtgctggac tctgatggct ccttcttcct     3180

ctactccaag ctcacagtgg acaagagcag gtggcagcag gggaatgtct tctcatgcag     3240

tgtgatgcat gaggctctgc acaaccacta cactcagaag agcctctccc tgtctcctgg     3300

caaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactca gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtggggga tagagtcaca attacttgca gagcttccca     3540

gggaataagg aactacttgg catggtatca gcaaaagcct gggaaagctc caaagttgct     3600

tatctatgct gccagcactc tgcagtcagg tgttcctagt agattctcag gcagtggaag     3660

tgggactgac tttacattaa ctatttcctc tctgcaacct gaggatgtgg ccacctatta     3720

ctgtcagagg tataatagag caccttacac atttggccaa ggtaccaaag tagaaatcaa     3780

gaggactgtg gctgcaccat ctgtcttcat cttcccccca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataatgccc tccaatcagg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacc ctgagcaaag cagactatga     4020

gaaacacaaa gtctatgcct gtgaagtcac ccatcagggc ctgagctccc cagtcacaaa     4080

gagcttcaac aggggagagt gttgacctag gtccataaag taggaaacac tacactattc     4140

cataaagtag gaaacactac atcactccat aaagtaggaa acactacaag tctccataaa     4200

gtaggaaaca ctacacaatt gctgtgcctt ctagttgcca gccatctgtt gtttgcccct     4260

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     4320

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     4380

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     4440

ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4500

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4560

ctcagtgagc gagcgagcgc gcagctgcag atctg                                4595


<210>  68
<211>  4802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #7 L-IRES-H (including ITRs)

<400>  68
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tacaggatgc aactcctgtc     1920

ttgcattgca ctaagtcttg cacttgtcac aaactcggac atccagatga cccaaagccc     1980

ctcctctctg tcagccagtg tgggcgatcg ggtcacaatt acttgcagag cttcgcaggg     2040

aataaggaac tacctcgcat ggtatcagca aaagcctggg aaagcgccaa agttgcttat     2100

ctacgccgcc agcacgctgc agtccggtgt tccgtctcgc ttctctggca gtggaagcgg     2160

gaccgacttt acattaacta tttcctctct gcaacccgag gatgtggcca cctattactg     2220

tcagcgatat aatcgtgcac cttacacatt cggccaaggt accaaagtag aaatcaagcg     2280

aactgtggct gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg     2340

aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg     2400

gaaggtggat aacgccctcc aatcgggcaa ctcccaggag agtgtcacag agcaggacag     2460

caaggacagc acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa     2520

acacaaagtc tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag     2580

cttcaacagg ggagagtgtt gagcccctct ccctcccccc cccctaacgt tactggccga     2640

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg     2700

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg     2760

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt     2820

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac     2880

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca     2940

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg     3000

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg     3060

ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa     3120

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat     3180

ggccacaatg cacagctcag cactgctctg ttgcctggtc ctcctgactg gggtgagggc     3240

cgaggtgcag ctggtcgaaa gcggcggagg gctcgttcaa cccggtcggt ccttgagact     3300

ttcttgcgcc gcttctggct tcacctttga cgattacgca atgcactggg tgaggcaggc     3360

gcctggaaag gggctggagt gggtatcagc catcacatgg aactcgggcc atattgacta     3420

tgctgatagc gtggaaggtc gcttcactat atcccgagac aatgccaaaa actctttata     3480

cctgcagatg aattcactac gtgcagagga tacggccgtc tattactgtg ctaaggtgtc     3540

atatctcagc accgcatcct ctctggacta ctggggacaa gggacattgg ttactgtgag     3600

ctccgcctcc accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc     3660

tgggggcaca gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt     3720

gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc     3780

ctcaggactc tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca     3840

gacctacatc tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga     3900

gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg     3960

gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac     4020

ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa     4080

ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta     4140

caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg     4200

caaggagtac aagtgcaagg tctccaacaa agccctccca gcccctatcg agaaaacaat     4260

ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga     4320

tgagctgacc aagaaccaag tcagcctgac ctgcctggtc aaaggcttct atcccagcga     4380

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc     4440

cgtgctggac tccgacggct ccttcttcct ctactccaag ctcaccgtgg acaagagcag     4500

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta     4560

cacgcagaag agcctctccc tgtctccggg caaatgacaa ttgaataaaa gatctttatt     4620

ttcattagat ctgtgtgttg gttttttgtg tggagctcga gaggaacccc tagtgatgga     4680

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4740

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcagatc     4800

tg                                                                    4802


<210>  69
<211>  4914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #8 L-IRES-H-miR142 (including ITRs)

<400>  69
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tacaggatgc aactcctgtc     1920

ttgcattgca ctaagtcttg cacttgtcac aaactcggac atccagatga cccaaagccc     1980

ctcctctctg tcagccagtg tgggcgatcg ggtcacaatt acttgcagag cttcgcaggg     2040

aataaggaac tacctcgcat ggtatcagca aaagcctggg aaagcgccaa agttgcttat     2100

ctacgccgcc agcacgctgc agtccggtgt tccgtctcgc ttctctggca gtggaagcgg     2160

gaccgacttt acattaacta tttcctctct gcaacccgag gatgtggcca cctattactg     2220

tcagcgatat aatcgtgcac cttacacatt cggccaaggt accaaagtag aaatcaagcg     2280

aactgtggct gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg     2340

aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg     2400

gaaggtggat aacgccctcc aatcgggcaa ctcccaggag agtgtcacag agcaggacag     2460

caaggacagc acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa     2520

acacaaagtc tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag     2580

cttcaacagg ggagagtgtt gagcccctct ccctcccccc cccctaacgt tactggccga     2640

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg     2700

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg     2760

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt     2820

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac     2880

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca     2940

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg     3000

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg     3060

ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa     3120

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat     3180

ggccacaatg cacagctcag cactgctctg ttgcctggtc ctcctgactg gggtgagggc     3240

cgaggtgcag ctggtcgaaa gcggcggagg gctcgttcaa cccggtcggt ccttgagact     3300

ttcttgcgcc gcttctggct tcacctttga cgattacgca atgcactggg tgaggcaggc     3360

gcctggaaag gggctggagt gggtatcagc catcacatgg aactcgggcc atattgacta     3420

tgctgatagc gtggaaggtc gcttcactat atcccgagac aatgccaaaa actctttata     3480

cctgcagatg aattcactac gtgcagagga tacggccgtc tattactgtg ctaaggtgtc     3540

atatctcagc accgcatcct ctctggacta ctggggacaa gggacattgg ttactgtgag     3600

ctccgcctcc accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc     3660

tgggggcaca gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt     3720

gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc     3780

ctcaggactc tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca     3840

gacctacatc tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga     3900

gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg     3960

gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac     4020

ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa     4080

ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta     4140

caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg     4200

caaggagtac aagtgcaagg tctccaacaa agccctccca gcccctatcg agaaaacaat     4260

ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga     4320

tgagctgacc aagaaccaag tcagcctgac ctgcctggtc aaaggcttct atcccagcga     4380

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc     4440

cgtgctggac tccgacggct ccttcttcct ctactccaag ctcaccgtgg acaagagcag     4500

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta     4560

cacgcagaag agcctctccc tgtctccggg caaatgagtt taaactccat aaagtaggaa     4620

acactacact attccataaa gtaggaaaca ctacatcact ccataaagta ggaaacacta     4680

caagtctcca taaagtagga aacactacac aattgaataa aagatcttta ttttcattag     4740

atctgtgtgt tggttttttg tgtggagctc gagaggaacc cctagtgatg gagttggcca     4800

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     4860

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcaga tctg           4914


<210>  70
<211>  4802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #9 L-IRES-H (including ITRs)

<400>  70
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tacaggatgc aactcctgtc     1920

ttgcattgca ctaagtcttg cacttgtcac aaactcagac atccagatga cccaaagccc     1980

ctcctctctg tcagccagtg tgggggatcg cgtcacaatt acttgcagag cttcccaggg     2040

aataaggaac tacctcgcgt ggtatcagca aaagcctggg aaagcgccaa agttgcttat     2100

ctatgccgcc agcactctgc agtcaggtgt tcctagtaga ttctctggca gtggaagcgg     2160

gactgacttt acattaacta tttcctctct gcaacctgag gatgtggcca cctattactg     2220

tcagcggtat aatcgcgcac cttacacatt tggccaaggt accaaagtag aaatcaagcg     2280

gactgtggct gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg     2340

aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg     2400

gaaggtggat aatgccctcc aaagtggcaa ctcccaggag agtgtcacag agcaggacag     2460

caaggacagc acctacagcc tcagcagcac cctgaccctg agcaaagcag actatgagaa     2520

acacaaagtc tacgcgtgtg aagtcaccca tcagggcctg agctccccag tcacaaagag     2580

cttcaacagg ggagagtgtt gagcccctct ccctcccccc cccctaacgt tactggccga     2640

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg     2700

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg     2760

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt     2820

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac     2880

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca     2940

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg     3000

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg     3060

ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa     3120

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat     3180

ggccacaatg cacagctcag cactgctctg ttgcctggtc ctcctgactg gggtgagggc     3240

tgaggtgcag ctggttgaaa gcggcggagg gcttgttcaa cctggtagat ccttgagact     3300

ttcttgcgcc gcttctggct tcacctttga tgattatgca atgcactggg tgaggcaggc     3360

gcctggaaag gggctggagt gggtatcagc catcacatgg aacagtggcc atattgacta     3420

tgctgatagt gtggaaggta gattcactat atcccgcgac aatgccaaaa actctttata     3480

cctgcagatg aattcactac gcgcagagga tactgcggtc tattactgtg ctaaggtgtc     3540

atatctcagc accgcatcct ctctggacta ctggggacaa gggacattgg ttactgtgag     3600

ctccgcctcc accaagggcc caagtgtctt ccccctggca ccctcctcca agagcacctc     3660

tgggggcaca gcggccctgg gctgcctggt caaggactac ttccctgaac ctgtgacagt     3720

gtcttggaac tcaggcgccc tgaccagcgg agtgcacacc ttcccagctg tcctacagtc     3780

ctcaggactc tactccctca gcagtgtggt gactgtgccc tccagcagct tgggcaccca     3840

gacctacatc tgcaatgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga     3900

gcccaaatct tgtgacaaaa ctcacacatg cccaccttgc ccagcacctg aactcctggg     3960

gggaccatca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccgcac     4020

ccctgaggtc acatgtgtgg tggtggatgt gagccatgaa gaccctgagg tcaagttcaa     4080

ctggtatgtg gatggtgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta     4140

caacagcaca tacagagtgg tctctgtcct cactgtcctg caccaggact ggctgaatgg     4200

caaggagtac aagtgcaagg tctccaacaa agccctccca gcccctattg agaaaacaat     4260

ctccaaagcc aaagggcagc ccagggaacc acaggtgtac accctgcccc catcccgcga     4320

tgagctgacc aagaaccagg tctccctgac ctgcctggtc aaaggcttct atcccagtga     4380

cattgctgtg gagtgggaga gcaatgggca gcctgagaac aactacaaga ccacacctcc     4440

agtgctggac tctgatggct ccttcttcct ctactccaag ctcactgtgg acaagagcag     4500

gtggcagcag gggaatgtct tctcatgcag tgtgatgcat gaggctctgc acaaccacta     4560

cacacagaag agcctctccc tgtctcctgg caaatgacaa ttgaataaaa gatctttatt     4620

ttcattagat ctgtgtgttg gttttttgtg tggagctcga gaggaacccc tagtgatgga     4680

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4740

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcagatc     4800

tg                                                                    4802


<210>  71
<211>  4914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #10 L-IRES-H-4xmiR142 (including ITRs)

<400>  71
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tacaggatgc aactcctgtc     1920

ttgcattgca ctaagtcttg cacttgtcac aaactcagac atccagatga cccaaagccc     1980

ctcctctctg tcagccagtg tgggggatcg cgtcacaatt acttgcagag cttcccaggg     2040

aataaggaac tacctcgcgt ggtatcagca aaagcctggg aaagcgccaa agttgcttat     2100

ctatgccgcc agcactctgc agtcaggtgt tcctagtaga ttctctggca gtggaagcgg     2160

gactgacttt acattaacta tttcctctct gcaacctgag gatgtggcca cctattactg     2220

tcagcggtat aatcgcgcac cttacacatt tggccaaggt accaaagtag aaatcaagcg     2280

gactgtggct gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg     2340

aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg     2400

gaaggtggat aatgccctcc aaagtggcaa ctcccaggag agtgtcacag agcaggacag     2460

caaggacagc acctacagcc tcagcagcac cctgaccctg agcaaagcag actatgagaa     2520

acacaaagtc tacgcgtgtg aagtcaccca tcagggcctg agctccccag tcacaaagag     2580

cttcaacagg ggagagtgtt gagcccctct ccctcccccc cccctaacgt tactggccga     2640

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg     2700

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg     2760

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt     2820

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac     2880

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca     2940

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg     3000

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg     3060

ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa     3120

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat     3180

ggccacaatg cacagctcag cactgctctg ttgcctggtc ctcctgactg gggtgagggc     3240

tgaggtgcag ctggttgaaa gcggcggagg gcttgttcaa cctggtagat ccttgagact     3300

ttcttgcgcc gcttctggct tcacctttga tgattatgca atgcactggg tgaggcaggc     3360

gcctggaaag gggctggagt gggtatcagc catcacatgg aacagtggcc atattgacta     3420

tgctgatagt gtggaaggta gattcactat atcccgcgac aatgccaaaa actctttata     3480

cctgcagatg aattcactac gcgcagagga tactgcggtc tattactgtg ctaaggtgtc     3540

atatctcagc accgcatcct ctctggacta ctggggacaa gggacattgg ttactgtgag     3600

ctccgcctcc accaagggcc caagtgtctt ccccctggca ccctcctcca agagcacctc     3660

tgggggcaca gcggccctgg gctgcctggt caaggactac ttccctgaac ctgtgacagt     3720

gtcttggaac tcaggcgccc tgaccagcgg agtgcacacc ttcccagctg tcctacagtc     3780

ctcaggactc tactccctca gcagtgtggt gactgtgccc tccagcagct tgggcaccca     3840

gacctacatc tgcaatgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga     3900

gcccaaatct tgtgacaaaa ctcacacatg cccaccttgc ccagcacctg aactcctggg     3960

gggaccatca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccgcac     4020

ccctgaggtc acatgtgtgg tggtggatgt gagccatgaa gaccctgagg tcaagttcaa     4080

ctggtatgtg gatggtgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta     4140

caacagcaca tacagagtgg tctctgtcct cactgtcctg caccaggact ggctgaatgg     4200

caaggagtac aagtgcaagg tctccaacaa agccctccca gcccctattg agaaaacaat     4260

ctccaaagcc aaagggcagc ccagggaacc acaggtgtac accctgcccc catcccgcga     4320

tgagctgacc aagaaccagg tctccctgac ctgcctggtc aaaggcttct atcccagtga     4380

cattgctgtg gagtgggaga gcaatgggca gcctgagaac aactacaaga ccacacctcc     4440

agtgctggac tctgatggct ccttcttcct ctactccaag ctcactgtgg acaagagcag     4500

gtggcagcag gggaatgtct tctcatgcag tgtgatgcat gaggctctgc acaaccacta     4560

cacacagaag agcctctccc tgtctcctgg caaatgagtt taaactccat aaagtaggaa     4620

acactacact attccataaa gtaggaaaca ctacatcact ccataaagta ggaaacacta     4680

caagtctcca taaagtagga aacactacac aattgaataa aagatcttta ttttcattag     4740

atctgtgtgt tggttttttg tgtggagctc gagaggaacc cctagtgatg gagttggcca     4800

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     4860

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcaga tctg           4914


<210>  72
<211>  4802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #11 L-IRES-H (including ITRs)

<400>  72
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tacaggatgc aactcctgtc     1920

ttgcattgca ctaagtcttg cacttgtcac aaactcagac atccagatga cccaaagccc     1980

ctcctctctg tcagccagtg tgggggatag agtcacaatt acttgcagag cttcccaggg     2040

aataaggaac tacttggcat ggtatcagca aaagcctggg aaagctccaa agttgcttat     2100

ctatgctgcc agcactctgc agtcaggtgt tcctagtaga ttctcaggca gtggaagtgg     2160

gactgacttt acattaacta tttcctctct gcaacctgag gatgtggcca cctattactg     2220

tcagaggtat aatagagcac cttacacatt tggccaaggt accaaagtag aaatcaagag     2280

gactgtggct gcaccatctg tcttcatctt ccccccatct gatgagcagt tgaaatctgg     2340

aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg     2400

gaaggtggat aatgccctcc aatcaggcaa ctcccaggag agtgtcacag agcaggacag     2460

caaggacagc acctacagcc tcagcagcac cctgaccctg agcaaagcag actatgagaa     2520

acacaaagtc tatgcctgtg aagtcaccca tcagggcctg agctccccag tcacaaagag     2580

cttcaacagg ggagagtgtt gagcccctct ccctcccccc cccctaacgt tactggccga     2640

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg     2700

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg     2760

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt     2820

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac     2880

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca     2940

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg     3000

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg     3060

ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa     3120

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat     3180

ggccacaatg cacagctcag cactgctctg ttgcctggtc ctcctgactg gggtgagggc     3240

tgaggtgcag ctggttgaaa gtggaggagg gcttgttcaa cctggtagat ccttgagact     3300

ttcttgtgct gcttctggct tcacctttga tgattatgca atgcactggg tgaggcaggc     3360

acctggaaag gggctggagt gggtatcagc catcacatgg aacagtggcc atattgacta     3420

tgctgatagt gtggaaggta gattcactat atccagagac aatgccaaaa actctttata     3480

cctgcagatg aattcactaa gggcagagga tactgctgtc tattactgtg ctaaggtatc     3540

atatctcagc acagcatcct ctctggacta ctggggacaa gggacattgg ttactgtgag     3600

ctctgcctcc accaagggcc caagtgtctt ccccctggca ccctcctcca agagcacctc     3660

tgggggcaca gcagccctgg gctgcctggt caaggactac ttccctgaac ctgtgactgt     3720

gtcttggaac tcaggtgccc tgaccagtgg agtgcacacc ttcccagctg tcctacagtc     3780

ctcaggactc tactccctga gctctgtggt gacagtgccc tccagcagct tgggcaccca     3840

gacctacatc tgcaatgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga     3900

gcccaaatct tgtgacaaaa ctcacacatg cccaccttgc ccagcacctg aactcctggg     3960

gggaccatca gtcttcctct tccccccaaa acccaaggac accctcatga tctccagaac     4020

ccctgaggtc acatgtgtgg tggtggatgt gagccatgaa gaccctgagg tcaagttcaa     4080

ctggtatgtg gatggtgtgg aggtgcataa tgccaagaca aagcccaggg aggagcagta     4140

caacagcact tacagagtgg tcagtgtcct cacagtcctg caccaggact ggctgaatgg     4200

caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccattg agaaaaccat     4260

ctccaaagcc aaagggcagc ccagggaacc acaggtgtac accctgcccc catccagaga     4320

tgagctgacc aagaaccagg tctccctgac ctgcctggtc aaaggcttct atccctctga     4380

cattgctgtg gagtgggaga gcaatgggca gccagagaac aactacaaga ccactcctcc     4440

tgtgctggac tctgatggct ccttcttcct ctactccaag ctcacagtgg acaagagcag     4500

gtggcagcag gggaatgtct tctcatgcag tgtgatgcat gaggctctgc acaaccacta     4560

cactcagaag agcctctccc tgtctcctgg caaatgacaa ttgaataaaa gatctttatt     4620

ttcattagat ctgtgtgttg gttttttgtg tggagctcga gaggaacccc tagtgatgga     4680

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4740

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcagatc     4800

tg                                                                    4802


<210>  73
<211>  4914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #12 L-IRES-H-4xmiR142 (including ITRs)

<400>  73
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tacaggatgc aactcctgtc     1920

ttgcattgca ctaagtcttg cacttgtcac aaactcagac atccagatga cccaaagccc     1980

ctcctctctg tcagccagtg tgggggatag agtcacaatt acttgcagag cttcccaggg     2040

aataaggaac tacttggcat ggtatcagca aaagcctggg aaagctccaa agttgcttat     2100

ctatgctgcc agcactctgc agtcaggtgt tcctagtaga ttctcaggca gtggaagtgg     2160

gactgacttt acattaacta tttcctctct gcaacctgag gatgtggcca cctattactg     2220

tcagaggtat aatagagcac cttacacatt tggccaaggt accaaagtag aaatcaagag     2280

gactgtggct gcaccatctg tcttcatctt ccccccatct gatgagcagt tgaaatctgg     2340

aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg     2400

gaaggtggat aatgccctcc aatcaggcaa ctcccaggag agtgtcacag agcaggacag     2460

caaggacagc acctacagcc tcagcagcac cctgaccctg agcaaagcag actatgagaa     2520

acacaaagtc tatgcctgtg aagtcaccca tcagggcctg agctccccag tcacaaagag     2580

cttcaacagg ggagagtgtt gagcccctct ccctcccccc cccctaacgt tactggccga     2640

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg     2700

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg     2760

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt     2820

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac     2880

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca     2940

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg     3000

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg     3060

ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa     3120

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat     3180

ggccacaatg cacagctcag cactgctctg ttgcctggtc ctcctgactg gggtgagggc     3240

tgaggtgcag ctggttgaaa gtggaggagg gcttgttcaa cctggtagat ccttgagact     3300

ttcttgtgct gcttctggct tcacctttga tgattatgca atgcactggg tgaggcaggc     3360

acctggaaag gggctggagt gggtatcagc catcacatgg aacagtggcc atattgacta     3420

tgctgatagt gtggaaggta gattcactat atccagagac aatgccaaaa actctttata     3480

cctgcagatg aattcactaa gggcagagga tactgctgtc tattactgtg ctaaggtatc     3540

atatctcagc acagcatcct ctctggacta ctggggacaa gggacattgg ttactgtgag     3600

ctctgcctcc accaagggcc caagtgtctt ccccctggca ccctcctcca agagcacctc     3660

tgggggcaca gcagccctgg gctgcctggt caaggactac ttccctgaac ctgtgactgt     3720

gtcttggaac tcaggtgccc tgaccagtgg agtgcacacc ttcccagctg tcctacagtc     3780

ctcaggactc tactccctga gctctgtggt gacagtgccc tccagcagct tgggcaccca     3840

gacctacatc tgcaatgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga     3900

gcccaaatct tgtgacaaaa ctcacacatg cccaccttgc ccagcacctg aactcctggg     3960

gggaccatca gtcttcctct tccccccaaa acccaaggac accctcatga tctccagaac     4020

ccctgaggtc acatgtgtgg tggtggatgt gagccatgaa gaccctgagg tcaagttcaa     4080

ctggtatgtg gatggtgtgg aggtgcataa tgccaagaca aagcccaggg aggagcagta     4140

caacagcact tacagagtgg tcagtgtcct cacagtcctg caccaggact ggctgaatgg     4200

caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccattg agaaaaccat     4260

ctccaaagcc aaagggcagc ccagggaacc acaggtgtac accctgcccc catccagaga     4320

tgagctgacc aagaaccagg tctccctgac ctgcctggtc aaaggcttct atccctctga     4380

cattgctgtg gagtgggaga gcaatgggca gccagagaac aactacaaga ccactcctcc     4440

tgtgctggac tctgatggct ccttcttcct ctactccaag ctcacagtgg acaagagcag     4500

gtggcagcag gggaatgtct tctcatgcag tgtgatgcat gaggctctgc acaaccacta     4560

cactcagaag agcctctccc tgtctcctgg caaatgagtt taaactccat aaagtaggaa     4620

acactacact attccataaa gtaggaaaca ctacatcact ccataaagta ggaaacacta     4680

caagtctcca taaagtagga aacactacac aattgaataa aagatcttta ttttcattag     4740

atctgtgtgt tggttttttg tgtggagctc gagaggaacc cctagtgatg gagttggcca     4800

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     4860

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcaga tctg           4914


<210>  74
<211>  4170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #13 DP-HL-opposite (including ITRs)

<400>  74
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga ccacacaaaa aaccaacaca cagatctaat      180

gaaaataaag atcttttatt cctaggtcat ttgcccggag acagggagag gctcttctgc      240

gtgtagtggt tgtgcagagc ctcatgcatc acggagcatg agaagacgtt cccctgctgc      300

cacctgctct tgtccacggt gagcttggag tagaggaaga aggagccgtc ggagtccagc      360

acgggaggcg tggtcttgta gttgttctcc ggctgcccat tgctctccca ctccacggcg      420

atgtcgctgg gatagaagcc tttgaccagg caggtcaggc tgacttggtt cttggtcagc      480

tcatcccggg atgggggcag ggtgtacacc tgtggttctc ggggctgccc tttggctttg      540

gagattgttt tctcgatagg ggctgggagg gctttgttgg agaccttgca cttgtactcc      600

ttgccattca gccagtcctg gtgcaggacg gtgaggacgc tgaccacacg gtacgtgctg      660

ttgtactgct cctcccgcgg ctttgtcttg gcattatgca cctccacgcc gtccacgtac      720

cagttgaact tgacctcagg gtcttcgtgg ctcacgtcca ccaccacgca tgtgacctca      780

ggggtccggg agatcatgag ggtgtccttg ggttttgggg ggaagaggaa gactgacggt      840

ccccccagga gttcaggtgc tgggcacggt gggcatgtgt gagttttgtc acaagatttg      900

ggctcaactt tcttgtccac cttggtgttg ctgggcttgt gattcacgtt gcagatgtag      960

gtctgggtgc ccaagctgct ggagggcacg gtcaccacgc tgctgaggga gtagagtcct     1020

gaggactgta ggacagccgg gaaggtgtgc acgccgctgg tcagggcgcc tgagttccac     1080

gacaccgtca ccggttcggg gaagtagtcc ttgaccaggc agcccagggc cgctgtgccc     1140

ccagaggtgc tcttggagga gggtgccagg gggaagaccg atgggccctt ggtggaggcg     1200

gagctcacag taaccaatgt cccttgtccc cagtagtcca gagaggatgc ggtgctgaga     1260

tatgacacct tagcacagta atagacggcc gtatcctctg cacgtagtga attcatctgc     1320

aggtataaag agtttttggc attgtctcgg gatatagtga agcgaccttc cacgctatca     1380

gcatagtcaa tatggcccga gttccatgtg atggctgata cccactccag cccctttcca     1440

ggcgcctgcc tcacccagtg cattgcgtaa tcgtcaaagg tgaagccaga agcggcgcaa     1500

gaaagtctca aggaccgacc gggttgaacg agccctccgc cgctttcgac cagctgcacc     1560

tcggccctca ccccagtcag gaggaccagg caacagagca gtgctgagct gtgcatggtg     1620

gtttaaacta gccttaagag ctgtaattga actgggagtg gacacctgtg gagagaaagg     1680

caaagtggat gtcagtaaga ccaataggtg cctatcagaa acgcaagagt cttctctgtc     1740

tcgacaagcc cagtttctat tggtctcctt aaacctgtct tgtaaccttg atacttacct     1800

gcccagtgcc tcacgaccaa cttcgatctg taacggcgca gaacagaaaa cgaaacaaag     1860

acgtagagtt gagcaagcag ggtcaggcaa agcgtggaga gccggctgag tctaggtagg     1920

ctccaaggga gcgccggaca aaggcccggt ctcgacctga gctttaaact tacctagacg     1980

gcggacgcag ttcaggaggc accacaggcg ggaggcggca gaacgcgact caaccggcgt     2040

ggatggcggc ctcaggtagg gcggcgggcg cgtgaaggag agatgcgagc ccctcgaagc     2100

ttcagctgtg ttctggcggc aaacccgttg cgaaaaagaa cgttcacggc gactactgca     2160

cttatatacg gttctccccc accctcggga aaaaggcgga gccagtacac gacatcactt     2220

tcccagttta ccccgcgcca ccttctctag gcaccggttc aattgccgac ccctcccccc     2280

aacttctcgg ggactgtggg cgatgtgcgc tctgcccact gacgggcacc ggagcattga     2340

ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg     2400

gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc     2460

cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat     2520

tgacgtcaat gggtggacta tttacggtaa actgcccact tggcagtaca tcaagtgtat     2580

catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat     2640

gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc     2700

gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac     2760

tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa     2820

aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt     2880

aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc     2940

tggagaagga actgaaaaac cagaaagtta actggtaagt ttagtctttt tgtcttttat     3000

ttcaggtccc ggatccggtg gtggtgcaaa tcaaagaact gctcctcagt ggatgttgcc     3060

tttacttcta ggcctgtacg gaagtgttac ttctgctcta aaagctgcgg aattgtagcc     3120

cggttaatta agccaccatg tacaggatgc aactcctgtc ttgcattgca ctaagtcttg     3180

cacttgtcac aaactcggac atccagatga cccaaagccc ctcctctctg tcagccagtg     3240

tgggcgatcg ggtcacaatt acttgcagag cttcgcaggg aataaggaac tacctcgcat     3300

ggtatcagca aaagcctggg aaagcgccaa agttgcttat ctacgccgcc agcacgctgc     3360

agtccggtgt tccgtctcgc ttctctggca gtggaagcgg gaccgacttt acattaacta     3420

tttcctctct gcaacccgag gatgtggcca cctattactg tcagcgatat aatcgtgcac     3480

cttacacatt cggccaaggt accaaagtag aaatcaagcg aactgtggct gcaccatctg     3540

tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc     3600

tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat aacgccctcc     3660

aatcgggcaa ctcccaggag agtgtcacag agcaggacag caaggacagc acctacagcc     3720

tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc tacgcctgcg     3780

aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg ggagagtgtt     3840

gagcatgcct gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     3900

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3960

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     4020

ggactcgaga ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     4080

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     4140

tgagcgagcg agcgcgcagc tgcagatctg                                      4170


<210>  75
<211>  4294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #14 DP-HL-same (including ITRs)

<400>  75
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gaaggaactg aaaaaccaga      780

aagttaactg gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg      840

tgcaaatcaa agaactgctc ctcagtggat gttgccttta cttctaggcc tgtacggaag      900

tgttacttct gctctaaaag ctgcggaatt gtagcccggt taattaagcc accatgcaca      960

gctcagcact gctctgttgc ctggtcctcc tgactggggt gagggccgag gtgcagctgg     1020

tcgaaagcgg cggagggctc gttcaacccg gtcggtcctt gagactttct tgcgccgctt     1080

ctggcttcac ctttgacgat tacgcaatgc actgggtgag gcaggcgcct ggaaaggggc     1140

tggagtgggt atcagccatc acatggaact cgggccatat tgactatgct gatagcgtgg     1200

aaggtcgctt cactatatcc cgagacaatg ccaaaaactc tttatacctg cagatgaatt     1260

cactacgtgc agaggatacg gccgtctatt actgtgctaa ggtgtcatat ctcagcaccg     1320

catcctctct ggactactgg ggacaaggga cattggttac tgtgagctcc gcctccacca     1380

agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg     1440

ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag     1500

gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact     1560

ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca     1620

acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc aaatcttgtg     1680

acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct     1740

tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat     1800

gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg     1860

gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc     1920

gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt     1980

gcaaggtctc caacaaagcc ctcccagccc ctatcgagaa aacaatctcc aaagccaaag     2040

ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga     2100

accaagtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt     2160

gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg     2220

acggctcctt cttcctctac tccaagctca ccgtggacaa gagcaggtgg cagcagggga     2280

acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc     2340

tctccctgtc tccgggcaaa tgagcatgcc tgtgccttct agttgccagc catctgttgt     2400

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     2460

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     2520

ggtggggcag gacagcaagg gggaggattc tcagaactaa catacgctct ccatcaaaac     2580

aaaacgaaac aaaacaaact agcaaaatag gctgtcccca gtgcaagtgc aggtgccaga     2640

acatttctct atcgaaggat ctgcgatcgc tccggtgccc gtcagtgggc agagcgcaca     2700

tcgcccacag tccccgagaa gttgggggga ggggtcggca attgaaccgg tgcctagaga     2760

aggtggcgcg gggtaaactg ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag     2820

ggtgggggag aaccgtatat aagtgcagta gtcgccgtga acgttctttt tcgcaacggg     2880

tttgccgcca gaacacagct gaagcttcga ggggctcgca tctctccttc acgcgcccgc     2940

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     3000

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     3060

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     3120

accctgcttg ctcaactcta cgtctttgtt tcgttttctg ttctgcgccg ttacagatcg     3180

aagttggtcg tgaggcactg ggcaggtaag tatcaaggtt acaagacagg tttaaggaga     3240

ccaatagaaa ctgggcttgt cgagacagag aagactcttg cgtttctgat aggcacctat     3300

tggtcttact gacatccact ttgcctttct ctccacaggt gtccactccc agttcaatta     3360

cagctcttaa ggctagttta aaccaccatg tacaggatgc aactcctgtc ttgcattgca     3420

ctaagtcttg cacttgtcac aaactcggac atccagatga cccaaagccc ctcctctctg     3480

tcagccagtg tgggcgatcg ggtcacaatt acttgcagag cttcgcaggg aataaggaac     3540

tacctcgcat ggtatcagca aaagcctggg aaagcgccaa agttgcttat ctacgccgcc     3600

agcacgctgc agtccggtgt tccgtctcgc ttctctggca gtggaagcgg gaccgacttt     3660

acattaacta tttcctctct gcaacccgag gatgtggcca cctattactg tcagcgatat     3720

aatcgtgcac cttacacatt cggccaaggt accaaagtag aaatcaagcg aactgtggct     3780

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct     3840

gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat     3900

aacgccctcc aatcgggcaa ctcccaggag agtgtcacag agcaggacag caaggacagc     3960

acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc     4020

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg     4080

ggagagtgtt gacctaggaa taaaagatct ttattttcat tagatctgtg tgttggtttt     4140

ttgtgtgctc gagaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     4200

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     4260

tcagtgagcg agcgagcgcg cagctgcaga tctg                                 4294


<210>  76
<211>  4170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #15 DP-LH-opposite (including ITRs)

<400>  76
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga ccacacaaaa aaccaacaca cagatctaat      180

gaaaataaag atcttttatt cctaggtcaa cactctcccc tgttgaagct ctttgtgacg      240

ggcgagctca ggccctgatg ggtgacttcg caggcgtaga ctttgtgttt ctcgtagtct      300

gctttgctca gcgtcagggt gctgctgagg ctgtaggtgc tgtccttgct gtcctgctct      360

gtgacactct cctgggagtt gcccgattgg agggcgttat ccaccttcca ctgtactttg      420

gcctctctgg gatagaagtt attcagcagg cacacaacag aggcagttcc agatttcaac      480

tgctcatcag atggcgggaa gatgaagaca gatggtgcag ccacagttcg cttgatttct      540

actttggtac cttggccgaa tgtgtaaggt gcacgattat atcgctgaca gtaataggtg      600

gccacatcct cgggttgcag agaggaaata gttaatgtaa agtcggtccc gcttccactg      660

ccagagaagc gagacggaac accggactgc agcgtgctgg cggcgtagat aagcaacttt      720

ggcgctttcc caggcttttg ctgataccat gcgaggtagt tccttattcc ctgcgaagct      780

ctgcaagtaa ttgtgacccg atcgcccaca ctggctgaca gagaggaggg gctttgggtc      840

atctggatgt ccgagtttgt gacaagtgca agacttagtg caatgcaaga caggagttgc      900

atcctgtaca tggtggttta aactagcctt aagagctgta attgaactgg gagtggacac      960

ctgtggagag aaaggcaaag tggatgtcag taagaccaat aggtgcctat cagaaacgca     1020

agagtcttct ctgtctcgac aagcccagtt tctattggtc tccttaaacc tgtcttgtaa     1080

ccttgatact tacctgccca gtgcctcacg accaacttcg atctgtaacg gcgcagaaca     1140

gaaaacgaaa caaagacgta gagttgagca agcagggtca ggcaaagcgt ggagagccgg     1200

ctgagtctag gtaggctcca agggagcgcc ggacaaaggc ccggtctcga cctgagcttt     1260

aaacttacct agacggcgga cgcagttcag gaggcaccac aggcgggagg cggcagaacg     1320

cgactcaacc ggcgtggatg gcggcctcag gtagggcggc gggcgcgtga aggagagatg     1380

cgagcccctc gaagcttcag ctgtgttctg gcggcaaacc cgttgcgaaa aagaacgttc     1440

acggcgacta ctgcacttat atacggttct cccccaccct cgggaaaaag gcggagccag     1500

tacacgacat cactttccca gtttaccccg cgccaccttc tctaggcacc ggttcaattg     1560

ccgacccctc cccccaactt ctcggggact gtgggcgatg tgcgctctgc ccactgacgg     1620

gcaccggagc attgattatt gactagttat taatagtaat caattacggg gtcattagtt     1680

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga     1740

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca     1800

atagggactt tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca     1860

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg     1920

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc     1980

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt     2040

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt     2100

ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg     2160

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg     2220

aaccgtcaga tcgcctggag aaggaactga aaaaccagaa agttaactgg taagtttagt     2280

ctttttgtct tttatttcag gtcccggatc cggtggtggt gcaaatcaaa gaactgctcc     2340

tcagtggatg ttgcctttac ttctaggcct gtacggaagt gttacttctg ctctaaaagc     2400

tgcggaattg tagcccggtt aattaagcca ccatgcacag ctcagcactg ctctgttgcc     2460

tggtcctcct gactggggtg agggccgagg tgcagctggt cgaaagcggc ggagggctcg     2520

ttcaacccgg tcggtccttg agactttctt gcgccgcttc tggcttcacc tttgacgatt     2580

acgcaatgca ctgggtgagg caggcgcctg gaaaggggct ggagtgggta tcagccatca     2640

catggaactc gggccatatt gactatgctg atagcgtgga aggtcgcttc actatatccc     2700

gagacaatgc caaaaactct ttatacctgc agatgaattc actacgtgca gaggatacgg     2760

ccgtctatta ctgtgctaag gtgtcatatc tcagcaccgc atcctctctg gactactggg     2820

gacaagggac attggttact gtgagctccg cctccaccaa gggcccatcg gtcttccccc     2880

tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc ctggtcaagg     2940

actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc     3000

acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc gtggtgaccg     3060

tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac aagcccagca     3120

acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac acatgcccac     3180

cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc ccaaaaccca     3240

aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg gacgtgagcc     3300

acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg cataatgcca     3360

agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg     3420

tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc aacaaagccc     3480

tcccagcccc tatcgagaaa acaatctcca aagccaaagg gcagccccga gaaccacagg     3540

tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaagtcagc ctgacctgcc     3600

tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat gggcagccgg     3660

agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc ttcctctact     3720

ccaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca tgctccgtga     3780

tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct ccgggcaaat     3840

gagcatgcct gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     3900

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     3960

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     4020

ggactcgaga ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     4080

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     4140

tgagcgagcg agcgcgcagc tgcagatctg                                      4170


<210>  77
<211>  4294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #16 DP-LH-Same (including ITRs)

<400>  77
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gaaggaactg aaaaaccaga      780

aagttaactg gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg      840

tgcaaatcaa agaactgctc ctcagtggat gttgccttta cttctaggcc tgtacggaag      900

tgttacttct gctctaaaag ctgcggaatt gtagcccggt taattaagcc accatgtaca      960

ggatgcaact cctgtcttgc attgcactaa gtcttgcact tgtcacaaac tcggacatcc     1020

agatgaccca aagcccctcc tctctgtcag ccagtgtggg cgatcgggtc acaattactt     1080

gcagagcttc gcagggaata aggaactacc tcgcatggta tcagcaaaag cctgggaaag     1140

cgccaaagtt gcttatctac gccgccagca cgctgcagtc cggtgttccg tctcgcttct     1200

ctggcagtgg aagcgggacc gactttacat taactatttc ctctctgcaa cccgaggatg     1260

tggccaccta ttactgtcag cgatataatc gtgcacctta cacattcggc caaggtacca     1320

aagtagaaat caagcgaact gtggctgcac catctgtctt catcttcccg ccatctgatg     1380

agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc tatcccagag     1440

aggccaaagt acagtggaag gtggataacg ccctccaatc gggcaactcc caggagagtg     1500

tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg acgctgagca     1560

aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag ggcctgagct     1620

cgcccgtcac aaagagcttc aacaggggag agtgttgagc atgcctgtgc cttctagttg     1680

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     1740

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     1800

tattctgggg ggtggggtgg ggcaggacag caagggggag gattctcaga actaacatac     1860

gctctccatc aaaacaaaac gaaacaaaac aaactagcaa aataggctgt ccccagtgca     1920

agtgcaggtg ccagaacatt tctctatcga aggatctgcg atcgctccgg tgcccgtcag     1980

tgggcagagc gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga     2040

accggtgcct agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc     2100

cgcctttttc ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt     2160

ctttttcgca acgggtttgc cgccagaaca cagctgaagc ttcgaggggc tcgcatctct     2220

ccttcacgcg cccgccgccc tacctgaggc cgccatccac gccggttgag tcgcgttctg     2280

ccgcctcccg cctgtggtgc ctcctgaact gcgtccgccg tctaggtaag tttaaagctc     2340

aggtcgagac cgggcctttg tccggcgctc ccttggagcc tacctagact cagccggctc     2400

tccacgcttt gcctgaccct gcttgctcaa ctctacgtct ttgtttcgtt ttctgttctg     2460

cgccgttaca gatcgaagtt ggtcgtgagg cactgggcag gtaagtatca aggttacaag     2520

acaggtttaa ggagaccaat agaaactggg cttgtcgaga cagagaagac tcttgcgttt     2580

ctgataggca cctattggtc ttactgacat ccactttgcc tttctctcca caggtgtcca     2640

ctcccagttc aattacagct cttaaggcta gtttaaacca ccatgcacag ctcagcactg     2700

ctctgttgcc tggtcctcct gactggggtg agggccgagg tgcagctggt cgaaagcggc     2760

ggagggctcg ttcaacccgg tcggtccttg agactttctt gcgccgcttc tggcttcacc     2820

tttgacgatt acgcaatgca ctgggtgagg caggcgcctg gaaaggggct ggagtgggta     2880

tcagccatca catggaactc gggccatatt gactatgctg atagcgtgga aggtcgcttc     2940

actatatccc gagacaatgc caaaaactct ttatacctgc agatgaattc actacgtgca     3000

gaggatacgg ccgtctatta ctgtgctaag gtgtcatatc tcagcaccgc atcctctctg     3060

gactactggg gacaagggac attggttact gtgagctccg cctccaccaa gggcccatcg     3120

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     3180

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     3240

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     3300

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     3360

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3420

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     3480

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     3540

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     3600

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     3660

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     3720

aacaaagccc tcccagcccc tatcgagaaa acaatctcca aagccaaagg gcagccccga     3780

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaagtcagc     3840

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     3900

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     3960

ttcctctact ccaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     4020

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     4080

ccgggcaaat gacctaggaa taaaagatct ttattttcat tagatctgtg tgttggtttt     4140

ttgtgtgctc gagaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     4200

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     4260

tcagtgagcg agcgagcgcg cagctgcaga tctg                                 4294


<210>  78
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector nucleotide sequence

<400>  78
gccgccatg                                                                9


<210>  79
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector nucleotide sequence

<400>  79
gcggccgcca tg                                                           12


<210>  80
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Kozak consensus sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein N is a purine (adenine or guanine)

<400>  80
ccnccaugg                                                                9


<210>  81
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' LTR

<400>  81
ggggctcgca tctctccttc acgcgcccgc cgccctacct gaggccgcca tccacgccgg       60

ttgagtcgcg ttctgccgcc tcccgcctgt ggtgcctcct gaactgcgtc cgccgtctag      120

gtaagtttaa agctcaggtc gagaccgggc ctttgtccgg cgctcccttg gagcctacct      180

agactcagcc ggctctccac gctttgcctg accctgcttg ctcaactcta cgtctttgtt      240

tcgttttctg ttctgcgccg ttacagatc                                        269


<210>  82
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Intron (chimera of human betaglobin intron and immunoglobulin 
       heavy chain intron)

<400>  82
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  83

<400>  83
000

<210>  84
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 adalimumab  #1

<400>  84
gattacgcaa tgcac                                                        15


<210>  85
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 adalimumab  #1

<400>  85
gccatcacat ggaactcggg ccatattgac tatgctgata gcgtggaagg t                51


<210>  86
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 adalimumab  #1

<400>  86
gtgagttatc tcagcaccgc acctctctgg actac                                  35


<210>  87
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 Codon modified adalimumab  #2

<400>  87
gattatgcaa tgcac                                                        15


<210>  88
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 Codon modified adalimumab  #2

<400>  88
gccatcacat ggaacagtgg ccatattgac tatgctgata gtgtggaagg t                51


<210>  89
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 Codon modified adalimumab  #2

<400>  89
gtgagttatc tcagcaccgc atcctctctg gactac                                 36


<210>  90
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 Codon modified adalimumab #3 & VH-CDR1 Codon modified 
       adalimumab #4

<400>  90
gattatgcaa tgcac                                                        15


<210>  91
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 Codon modified adalimumab #3 & VH-CDR2 Codon modified 
       adalimumab #4

<400>  91
gccatcacat ggaacagtgg ccatattgac tatgctgata gtgtggaagg t                51


<210>  92
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 Codon modified adalimumab #3

<400>  92
gtgagttatc tcagcacagc atcctctctg gactac                                 36


<210>  93
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 adalimumab #1

<400>  93
agagcttcgc agggaataag gaactacctc gca                                    33


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 adalimumab #1

<400>  94
gccgctagca cgctgcagtc c                                                 21


<210>  95
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 adalimumab #1

<400>  95
cagcgatata atcgtgcacc ttacaca                                           27


<210>  96
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 Codon modified adalimumab #2

<400>  96
agagcttccc agggaataag gaactacctc gcg                                    33


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 Codon modified adalimumab #2

<400>  97
gccgctagca ctctgcagtc a                                                 21


<210>  98
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 Codon modified adalimumab #2

<400>  98
cagcggtata atcgcgcacc ttacaca                                           27


<210>  99
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 Codon modified adalimumab #3

<400>  99
agagcttccc agggaataag gaactacttg gca                                    33


<210>  100
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 Codon modified adalimumab #3

<400>  100
gctgctagca ctctgcagtc a                                                 21


<210>  101
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 Codon modified adalimumab #3

<400>  101
cagaggtata atagagcacc ttacaca                                           27


<210>  102
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH #4 Codon modified adalimumab VH

<400>  102
gaggtgcagc tggttgaaag cggcggaggg cttgttcaac ctggtagatc cttgagactt       60

tcttgcgccg cttctggctt cacctttgat gattatgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtatcagcc atcacatgga acagtggcca tattgactat      180

gctgatagtg tggaaggtag attcactata tcccgcgaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg cgcagaggat actgcggtct attactgtgc taaggtgtca      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tcc                                                                    363


<210>  103
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL #4 Codon modified adalimumab VL

<400>  103
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca       60

attacttgca gagcttccca gggaataagg aactacctcg cgtggtatca gcaaaagcct      120

gggaaagcgc caaagttgct tatctatgcc gccagcactc tgcagtcagg tgttcctagt      180

agattctctg gcagtggaag cgggactgac tttacattaa ctatttcctc tctgcaacct      240

gaggatgtgg ccacctatta ctgtcagcgg tataatcgcg caccttacac atttggccaa      300

ggtaccaaag tagaaatcaa g                                                321


<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 Codon modified adalimumab #4

<400>  106
gtgtcatatc tcagcaccgc atcctctctg gactac                                 36


<210>  107
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 Codon modified adalimumab #4

<400>  107
agagcttccc agggaataag gaactacctc gcg                                    33


<210>  108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 Codon modified adalimumab #4

<400>  108
gccgccagca ctctgcagtc a                                                 21


<210>  109
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 Codon modified adalimumab #4

<400>  109
cagcggtata atcgcgcacc ttacaca                                           27


<210>  110
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC #4

<400>  110
gaggtgcagc tggttgaaag cggcggaggg cttgttcaac ctggtagatc cttgagactt       60

tcttgcgccg cttctggctt cacctttgat gattatgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtatcagcc atcacatgga acagtggcca tattgactat      180

gctgatagtg tggaaggtag attcactata tcccgcgaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg cgcagaggat actgcggtct attactgtgc taaggtgtca      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tccgcctcca ccaagggccc aagtgtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccctgaacc tgtgacagtg      480

tcttggaact caggcgccct gaccagcgga gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagtgtggtg actgtgccct ccagcagctt gggcacccag      600

acctacatct gcaatgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccttgcc cagcacctga actcctgggg      720

ggaccatcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccgcacc      780

cctgaggtca catgtgtggt ggtggatgtg agccatgaag accctgaggt caagttcaac      840

tggtatgtgg atggtgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacat acagagtggt ctctgtcctc actgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccctattga gaaaacaatc     1020

tccaaagcca aagggcagcc cagggaacca caggtgtaca ccctgccccc atcccgcgat     1080

gagctgacca agaaccaggt ctccctgacc tgcctggtca aaggcttcta tcccagtgac     1140

attgctgtgg agtgggagag caatgggcag cctgagaaca actacaagac cacacctcca     1200

gtgctggact ctgatggctc cttcttcctc tactccaagc tcactgtgga caagagcagg     1260

tggcagcagg ggaatgtctt ctcatgcagt gtgatgcatg aggctctgca caaccactac     1320

acacagaaga gcctctccct gtctcctggt aaa                                  1353


<210>  111
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC #4

<400>  111
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca       60

attacttgca gagcttccca gggaataagg aactacctcg cgtggtatca gcaaaagcct      120

gggaaagcgc caaagttgct tatctatgcc gccagcactc tgcagtcagg tgttcctagt      180

agattctctg gcagtggaag cgggactgac tttacattaa ctatttcctc tctgcaacct      240

gaggatgtgg ccacctatta ctgtcagcgg tataatcgcg caccttacac atttggccaa      300

ggtaccaaag tagaaatcaa gcggactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaaagtgg caactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      540

ctgagcaaag cagactatga gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc      600

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      645


<210>  112
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-10 leader

<400>  112
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggct             54


<210>  113
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 leader

<400>  113
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaactca       60


<210>  114
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HGH poly(A)

<400>  114
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  115
<211>  4190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #1 H-F2A-L Antibody expression cassette (w/o ITRs)

<400>  115
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgcacag ctcagcactg ctctgttgcc tggtcctcct gactggggtg     1800

agggccgagg tgcagctggt cgaaagcggc ggagggctcg ttcaacccgg tcggtccttg     1860

agactttctt gcgccgcttc tggcttcacc tttgacgatt acgcaatgca ctgggtgagg     1920

caggcgcctg gaaaggggct ggagtgggta tcagccatca catggaactc gggccatatt     1980

gactatgctg atagcgtgga aggtcgcttc actatatccc gagacaatgc caaaaactct     2040

ttatacctgc agatgaattc actacgtgca gaggatacgg ccgtctatta ctgtgctaag     2100

gtgtcatatc tcagcaccgc atcctctctg gactactggg gacaagggac attggttact     2160

gtgagctccg cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc     2220

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg     2280

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     2340

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     2400

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa     2460

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc     2520

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     2580

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     2640

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     2700

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     2760

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc tatcgagaaa     2820

acaatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     2880

cgggatgagc tgaccaagaa ccaagtcagc ctgacctgcc tggtcaaagg cttctatccc     2940

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     3000

cctcccgtgc tggactccga cggctccttc ttcctctact ccaagctcac cgtggacaag     3060

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     3120

cactacacgc agaagagcct ctccctgtct ccgggtaaaa gaaagagaag gagtggctca     3180

ggagcccctg tgaaacagac cctgaacttt gacctcttga agcttgctgg ggatgtggag     3240

tctaatcctg gtccaatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     3300

cttgtcacaa actcggacat ccagatgacc caaagcccct cctctctgtc agccagtgtg     3360

ggcgatcggg tcacaattac ttgcagagct tcgcagggaa taaggaacta cctcgcatgg     3420

tatcagcaaa agcctgggaa agcgccaaag ttgcttatct acgccgccag cacgctgcag     3480

tccggtgttc cgtctcgctt ctctggcagt ggaagcggga ccgactttac attaactatt     3540

tcctctctgc aacccgagga tgtggccacc tattactgtc agcgatataa tcgtgcacct     3600

tacacattcg gccaaggtac caaagtagaa atcaagcgaa ctgtggctgc accatctgtc     3660

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     3720

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa     3780

tcgggcaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     3840

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa     3900

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttga     3960

caattgctgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     4020

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     4080

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     4140

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg                4190


<210>  116
<211>  4300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #2 H-F2A-L-4xmiR142 Antibody expression cassette (w/o ITRs)

<400>  116
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgcacag ctcagcactg ctctgttgcc tggtcctcct gactggggtg     1800

agggccgagg tgcagctggt cgaaagcggc ggagggctcg ttcaacccgg tcggtccttg     1860

agactttctt gcgccgcttc tggcttcacc tttgacgatt acgcaatgca ctgggtgagg     1920

caggcgcctg gaaaggggct ggagtgggta tcagccatca catggaactc gggccatatt     1980

gactatgctg atagcgtgga aggtcgcttc actatatccc gagacaatgc caaaaactct     2040

ttatacctgc agatgaattc actacgtgca gaggatacgg ccgtctatta ctgtgctaag     2100

gtgtcatatc tcagcaccgc atcctctctg gactactggg gacaagggac attggttact     2160

gtgagctccg cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc     2220

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg     2280

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     2340

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     2400

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa     2460

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc     2520

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     2580

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     2640

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     2700

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     2760

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc tatcgagaaa     2820

acaatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     2880

cgggatgagc tgaccaagaa ccaagtcagc ctgacctgcc tggtcaaagg cttctatccc     2940

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     3000

cctcccgtgc tggactccga cggctccttc ttcctctact ccaagctcac cgtggacaag     3060

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     3120

cactacacgc agaagagcct ctccctgtct ccgggtaaaa gaaagagaag gagtggctca     3180

ggagcccctg tgaaacagac cctgaacttt gacctcttga agcttgctgg ggatgtggag     3240

tctaatcctg gtccaatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     3300

cttgtcacaa actcggacat ccagatgacc caaagcccct cctctctgtc agccagtgtg     3360

ggcgatcggg tcacaattac ttgcagagct tcgcagggaa taaggaacta cctcgcatgg     3420

tatcagcaaa agcctgggaa agcgccaaag ttgcttatct acgccgccag cacgctgcag     3480

tccggtgttc cgtctcgctt ctctggcagt ggaagcggga ccgactttac attaactatt     3540

tcctctctgc aacccgagga tgtggccacc tattactgtc agcgatataa tcgtgcacct     3600

tacacattcg gccaaggtac caaagtagaa atcaagcgaa ctgtggctgc accatctgtc     3660

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     3720

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa     3780

tcgggcaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     3840

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa     3900

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttga     3960

cctaggtcca taaagtagga aacactacac tattccataa agtaggaaac actacatcac     4020

tccataaagt aggaaacact acaagtctcc ataaagtagg aaacactaca caattgctgt     4080

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga     4140

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag     4200

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     4260

agacaatagc aggcatgctg gggatgcggt gggctctatg                           4300


<210>  117
<211>  4190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #3 H-F2A-L Antibody expression cassette (w/o ITRs)

<400>  117
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgcacag ctcagcactg ctctgttgcc tggtcctcct gactggggtg     1800

agggctgagg tgcagctggt tgaaagcggc ggagggcttg ttcaacctgg tagatccttg     1860

agactttctt gcgccgcttc tggcttcacc tttgatgatt atgcaatgca ctgggtgagg     1920

caggcgcctg gaaaggggct ggagtgggta tcagccatca catggaacag tggccatatt     1980

gactatgctg atagtgtgga aggtagattc actatatccc gcgacaatgc caaaaactct     2040

ttatacctgc agatgaattc actacgcgca gaggatactg cggtctatta ctgtgctaag     2100

gtgtcatatc tcagcaccgc atcctctctg gactactggg gacaagggac attggttact     2160

gtgagctccg cctccaccaa gggcccaagt gtcttccccc tggcaccctc ctccaagagc     2220

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc tgaacctgtg     2280

acagtgtctt ggaactcagg cgccctgacc agcggagtgc acaccttccc agctgtccta     2340

cagtcctcag gactctactc cctcagcagt gtggtgactg tgccctccag cagcttgggc     2400

acccagacct acatctgcaa tgtgaatcac aagcccagca acaccaaggt ggacaagaaa     2460

gttgagccca aatcttgtga caaaactcac acatgcccac cttgcccagc acctgaactc     2520

ctggggggac catcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     2580

cgcacccctg aggtcacatg tgtggtggtg gatgtgagcc atgaagaccc tgaggtcaag     2640

ttcaactggt atgtggatgg tgtggaggtg cataatgcca agacaaagcc gcgggaggag     2700

cagtacaaca gcacatacag agtggtctct gtcctcactg tcctgcacca ggactggctg     2760

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc tattgagaaa     2820

acaatctcca aagccaaagg gcagcccagg gaaccacagg tgtacaccct gcccccatcc     2880

cgcgatgagc tgaccaagaa ccaggtctcc ctgacctgcc tggtcaaagg cttctatccc     2940

agtgacattg ctgtggagtg ggagagcaat gggcagcctg agaacaacta caagaccaca     3000

cctccagtgc tggactctga tggctccttc ttcctctact ccaagctcac tgtggacaag     3060

agcaggtggc agcaggggaa tgtcttctca tgcagtgtga tgcatgaggc tctgcacaac     3120

cactacacac agaagagcct ctccctgtct cctggtaaaa gaaagagaag gagtggctca     3180

ggagcccctg tgaaacagac cctgaacttt gacctcttga agcttgctgg ggatgtggag     3240

tctaatcctg gtccaatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     3300

cttgtcacaa actcagacat ccagatgacc caaagcccct cctctctgtc agccagtgtg     3360

ggggatcgcg tcacaattac ttgcagagct tcccagggaa taaggaacta cctcgcgtgg     3420

tatcagcaaa agcctgggaa agcgccaaag ttgcttatct atgccgccag cactctgcag     3480

tcaggtgttc ctagtagatt ctctggcagt ggaagcggga ctgactttac attaactatt     3540

tcctctctgc aacctgagga tgtggccacc tattactgtc agcggtataa tcgcgcacct     3600

tacacatttg gccaaggtac caaagtagaa atcaagcgga ctgtggctgc accatctgtc     3660

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     3720

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa tgccctccaa     3780

agtggcaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     3840

agcagcaccc tgaccctgag caaagcagac tatgagaaac acaaagtcta cgcgtgtgaa     3900

gtcacccatc agggcctgag ctccccagtc acaaagagct tcaacagggg agagtgttga     3960

caattgctgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     4020

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     4080

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     4140

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg                4190


<210>  118
<211>  4595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #4 H-F2A-L-4xmiR142 Antibody expression cassette (w/o ITRs)

<400>  118
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc tgaggtgcag ctggttgaaa gcggcggagg     1980

gcttgttcaa cctggtagat ccttgagact ttcttgcgcc gcttctggct tcacctttga     2040

tgattatgca atgcactggg tgaggcaggc gcctggaaag gggctggagt gggtatcagc     2100

catcacatgg aacagtggcc atattgacta tgctgatagt gtggaaggta gattcactat     2160

atcccgcgac aatgccaaaa actctttata cctgcagatg aattcactac gcgcagagga     2220

tactgcggtc tattactgtg ctaaggtgtc atatctcagc accgcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctccgcctcc accaagggcc caagtgtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     2400

caaggactac ttccctgaac ctgtgacagt gtcttggaac tcaggcgccc tgaccagcgg     2460

agtgcacacc ttcccagctg tcctacagtc ctcaggactc tactccctca gcagtgtggt     2520

gactgtgccc tccagcagct tgggcaccca gacctacatc tgcaatgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccttgc ccagcacctg aactcctggg gggaccatca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctcccgcac ccctgaggtc acatgtgtgg tggtggatgt     2760

gagccatgaa gaccctgagg tcaagttcaa ctggtatgtg gatggtgtgg aggtgcataa     2820

tgccaagaca aagccgcggg aggagcagta caacagcaca tacagagtgg tctctgtcct     2880

cactgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccctattg agaaaacaat ctccaaagcc aaagggcagc ccagggaacc     3000

acaggtgtac accctgcccc catcccgcga tgagctgacc aagaaccagg tctccctgac     3060

ctgcctggtc aaaggcttct atcccagtga cattgctgtg gagtgggaga gcaatgggca     3120

gcctgagaac aactacaaga ccacacctcc agtgctggac tctgatggct ccttcttcct     3180

ctactccaag ctcactgtgg acaagagcag gtggcagcag gggaatgtct tctcatgcag     3240

tgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc tgtctcctgg     3300

taaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactca gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca attacttgca gagcttccca     3540

gggaataagg aactacctcg cgtggtatca gcaaaagcct gggaaagcgc caaagttgct     3600

tatctatgcc gccagcactc tgcagtcagg tgttcctagt agattctctg gcagtggaag     3660

cgggactgac tttacattaa ctatttcctc tctgcaacct gaggatgtgg ccacctatta     3720

ctgtcagcgg tataatcgcg caccttacac atttggccaa ggtaccaaag tagaaatcaa     3780

gcggactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataatgccc tccaaagtgg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacc ctgagcaaag cagactatga     4020

gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc ctgagctccc cagtcacaaa     4080

gagcttcaac aggggagagt gttgacctag gtccataaag taggaaacac tacactattc     4140

cataaagtag gaaacactac atcactccat aaagtaggaa acactacaag tctccataaa     4200

gtaggaaaca ctacacaatt gctgtgcctt ctagttgcca gccatctgtt gtttgcccct     4260

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     4320

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     4380

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     4440

ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4500

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4560

ctcagtgagc gagcgagcgc gcagctgcag atctg                                4595


<210>  119
<211>  4190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #5 H-F2A-L Antibody expression cassette (w/o ITRs)

<400>  119
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgcacag ctcagcactg ctctgttgcc tggtcctcct gactggggtg     1800

agggctgagg tgcagctggt tgaaagtgga ggagggcttg ttcaacctgg tagatccttg     1860

agactttctt gtgctgcttc tggcttcacc tttgatgatt atgcaatgca ctgggtgagg     1920

caggcacctg gaaaggggct ggagtgggta tcagccatca catggaacag tggccatatt     1980

gactatgctg atagtgtgga aggtagattc actatatcca gagacaatgc caaaaactct     2040

ttatacctgc agatgaattc actaagggca gaggatactg ctgtctatta ctgtgctaag     2100

gtatcatatc tcagcacagc atcctctctg gactactggg gacaagggac attggttact     2160

gtgagctctg cctccaccaa gggcccaagt gtcttccccc tggcaccctc ctccaagagc     2220

acctctgggg gcacagcagc cctgggctgc ctggtcaagg actacttccc tgaacctgtg     2280

actgtgtctt ggaactcagg tgccctgacc agtggagtgc acaccttccc agctgtccta     2340

cagtcctcag gactctactc cctgagctct gtggtgacag tgccctccag cagcttgggc     2400

acccagacct acatctgcaa tgtgaatcac aagcccagca acaccaaggt ggacaagaaa     2460

gttgagccca aatcttgtga caaaactcac acatgcccac cttgcccagc acctgaactc     2520

ctggggggac catcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     2580

agaacccctg aggtcacatg tgtggtggtg gatgtgagcc atgaagaccc tgaggtcaag     2640

ttcaactggt atgtggatgg tgtggaggtg cataatgcca agacaaagcc cagggaggag     2700

cagtacaaca gcacttacag agtggtcagt gtcctcacag tcctgcacca ggactggctg     2760

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc cattgagaaa     2820

accatctcca aagccaaagg gcagcccagg gaaccacagg tgtacaccct gcccccatcc     2880

agagatgagc tgaccaagaa ccaggtctcc ctgacctgcc tggtcaaagg cttctatccc     2940

tctgacattg ctgtggagtg ggagagcaat gggcagccag agaacaacta caagaccact     3000

cctcctgtgc tggactctga tggctccttc ttcctctact ccaagctcac agtggacaag     3060

agcaggtggc agcaggggaa tgtcttctca tgcagtgtga tgcatgaggc tctgcacaac     3120

cactacactc agaagagcct ctccctgtct cctggcaaaa gaaagagaag gagtggctca     3180

ggagcccctg tgaaacagac cctgaacttt gacctcttga agcttgctgg ggatgtggag     3240

tctaatcctg gtccaatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     3300

cttgtcacaa actcagacat ccagatgacc caaagcccct cctctctgtc agccagtgtg     3360

ggggatagag tcacaattac ttgcagagct tcccagggaa taaggaacta cttggcatgg     3420

tatcagcaaa agcctgggaa agctccaaag ttgcttatct atgctgccag cactctgcag     3480

tcaggtgttc ctagtagatt ctcaggcagt ggaagtggga ctgactttac attaactatt     3540

tcctctctgc aacctgagga tgtggccacc tattactgtc agaggtataa tagagcacct     3600

tacacatttg gccaaggtac caaagtagaa atcaagagga ctgtggctgc accatctgtc     3660

ttcatcttcc ccccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     3720

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa tgccctccaa     3780

tcaggcaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     3840

agcagcaccc tgaccctgag caaagcagac tatgagaaac acaaagtcta tgcctgtgaa     3900

gtcacccatc agggcctgag ctccccagtc acaaagagct tcaacagggg agagtgttga     3960

caattgctgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     4020

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     4080

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     4140

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg                4190


<210>  120

<400>  120
000

<210>  121
<211>  4300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #6 H-F2A-L-4xmiR142 Antibody expression cassette (w/o ITRs)

<400>  121
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgcacag ctcagcactg ctctgttgcc tggtcctcct gactggggtg     1800

agggctgagg tgcagctggt tgaaagtgga ggagggcttg ttcaacctgg tagatccttg     1860

agactttctt gtgctgcttc tggcttcacc tttgatgatt atgcaatgca ctgggtgagg     1920

caggcacctg gaaaggggct ggagtgggta tcagccatca catggaacag tggccatatt     1980

gactatgctg atagtgtgga aggtagattc actatatcca gagacaatgc caaaaactct     2040

ttatacctgc agatgaattc actaagggca gaggatactg ctgtctatta ctgtgctaag     2100

gtatcatatc tcagcacagc atcctctctg gactactggg gacaagggac attggttact     2160

gtgagctctg cctccaccaa gggcccaagt gtcttccccc tggcaccctc ctccaagagc     2220

acctctgggg gcacagcagc cctgggctgc ctggtcaagg actacttccc tgaacctgtg     2280

actgtgtctt ggaactcagg tgccctgacc agtggagtgc acaccttccc agctgtccta     2340

cagtcctcag gactctactc cctgagctct gtggtgacag tgccctccag cagcttgggc     2400

acccagacct acatctgcaa tgtgaatcac aagcccagca acaccaaggt ggacaagaaa     2460

gttgagccca aatcttgtga caaaactcac acatgcccac cttgcccagc acctgaactc     2520

ctggggggac catcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     2580

agaacccctg aggtcacatg tgtggtggtg gatgtgagcc atgaagaccc tgaggtcaag     2640

ttcaactggt atgtggatgg tgtggaggtg cataatgcca agacaaagcc cagggaggag     2700

cagtacaaca gcacttacag agtggtcagt gtcctcacag tcctgcacca ggactggctg     2760

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc cattgagaaa     2820

accatctcca aagccaaagg gcagcccagg gaaccacagg tgtacaccct gcccccatcc     2880

agagatgagc tgaccaagaa ccaggtctcc ctgacctgcc tggtcaaagg cttctatccc     2940

tctgacattg ctgtggagtg ggagagcaat gggcagccag agaacaacta caagaccact     3000

cctcctgtgc tggactctga tggctccttc ttcctctact ccaagctcac agtggacaag     3060

agcaggtggc agcaggggaa tgtcttctca tgcagtgtga tgcatgaggc tctgcacaac     3120

cactacactc agaagagcct ctccctgtct cctggcaaaa gaaagagaag gagtggctca     3180

ggagcccctg tgaaacagac cctgaacttt gacctcttga agcttgctgg ggatgtggag     3240

tctaatcctg gtccaatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     3300

cttgtcacaa actcagacat ccagatgacc caaagcccct cctctctgtc agccagtgtg     3360

ggggatagag tcacaattac ttgcagagct tcccagggaa taaggaacta cttggcatgg     3420

tatcagcaaa agcctgggaa agctccaaag ttgcttatct atgctgccag cactctgcag     3480

tcaggtgttc ctagtagatt ctcaggcagt ggaagtggga ctgactttac attaactatt     3540

tcctctctgc aacctgagga tgtggccacc tattactgtc agaggtataa tagagcacct     3600

tacacatttg gccaaggtac caaagtagaa atcaagagga ctgtggctgc accatctgtc     3660

ttcatcttcc ccccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     3720

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa tgccctccaa     3780

tcaggcaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     3840

agcagcaccc tgaccctgag caaagcagac tatgagaaac acaaagtcta tgcctgtgaa     3900

gtcacccatc agggcctgag ctccccagtc acaaagagct tcaacagggg agagtgttga     3960

cctaggtcca taaagtagga aacactacac tattccataa agtaggaaac actacatcac     4020

tccataaagt aggaaacact acaagtctcc ataaagtagg aaacactaca caattgctgt     4080

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga     4140

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag     4200

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     4260

agacaatagc aggcatgctg gggatgcggt gggctctatg                           4300


<210>  122
<211>  4507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #7 L-IRES-H Antibody expression cassette (w/o ITRs)

<400>  122
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt     1800

gtcacaaact cggacatcca gatgacccaa agcccctcct ctctgtcagc cagtgtgggc     1860

gatcgggtca caattacttg cagagcttcg cagggaataa ggaactacct cgcatggtat     1920

cagcaaaagc ctgggaaagc gccaaagttg cttatctacg ccgccagcac gctgcagtcc     1980

ggtgttccgt ctcgcttctc tggcagtgga agcgggaccg actttacatt aactatttcc     2040

tctctgcaac ccgaggatgt ggccacctat tactgtcagc gatataatcg tgcaccttac     2100

acattcggcc aaggtaccaa agtagaaatc aagcgaactg tggctgcacc atctgtcttc     2160

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     2220

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg     2280

ggcaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     2340

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc     2400

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttgagcc     2460

cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg     2520

cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga     2580

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa     2640

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa     2700

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct     2760

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg     2820

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg     2880

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca     2940

catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg     3000

acgtggtttt cctttgaaaa acacgatgat aatatggcca caatgcacag ctcagcactg     3060

ctctgttgcc tggtcctcct gactggggtg agggccgagg tgcagctggt cgaaagcggc     3120

ggagggctcg ttcaacccgg tcggtccttg agactttctt gcgccgcttc tggcttcacc     3180

tttgacgatt acgcaatgca ctgggtgagg caggcgcctg gaaaggggct ggagtgggta     3240

tcagccatca catggaactc gggccatatt gactatgctg atagcgtgga aggtcgcttc     3300

actatatccc gagacaatgc caaaaactct ttatacctgc agatgaattc actacgtgca     3360

gaggatacgg ccgtctatta ctgtgctaag gtgtcatatc tcagcaccgc atcctctctg     3420

gactactggg gacaagggac attggttact gtgagctccg cctccaccaa gggcccatcg     3480

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     3540

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     3600

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     3660

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     3720

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3780

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     3840

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     3900

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     3960

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     4020

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     4080

aacaaagccc tcccagcccc tatcgagaaa acaatctcca aagccaaagg gcagccccga     4140

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaagtcagc     4200

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     4260

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     4320

ttcctctact ccaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     4380

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     4440

ccgggcaaat gacaattgaa taaaagatct ttattttcat tagatctgtg tgttggtttt     4500

ttgtgtg                                                               4507


<210>  123
<211>  4619
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #8 L-IRES-H-miR142 Antibody expression cassette (w/o ITRs)

<400>  123
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt     1800

gtcacaaact cggacatcca gatgacccaa agcccctcct ctctgtcagc cagtgtgggc     1860

gatcgggtca caattacttg cagagcttcg cagggaataa ggaactacct cgcatggtat     1920

cagcaaaagc ctgggaaagc gccaaagttg cttatctacg ccgccagcac gctgcagtcc     1980

ggtgttccgt ctcgcttctc tggcagtgga agcgggaccg actttacatt aactatttcc     2040

tctctgcaac ccgaggatgt ggccacctat tactgtcagc gatataatcg tgcaccttac     2100

acattcggcc aaggtaccaa agtagaaatc aagcgaactg tggctgcacc atctgtcttc     2160

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     2220

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg     2280

ggcaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     2340

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc     2400

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttgagcc     2460

cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg     2520

cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga     2580

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa     2640

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa     2700

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct     2760

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg     2820

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg     2880

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca     2940

catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg     3000

acgtggtttt cctttgaaaa acacgatgat aatatggcca caatgcacag ctcagcactg     3060

ctctgttgcc tggtcctcct gactggggtg agggccgagg tgcagctggt cgaaagcggc     3120

ggagggctcg ttcaacccgg tcggtccttg agactttctt gcgccgcttc tggcttcacc     3180

tttgacgatt acgcaatgca ctgggtgagg caggcgcctg gaaaggggct ggagtgggta     3240

tcagccatca catggaactc gggccatatt gactatgctg atagcgtgga aggtcgcttc     3300

actatatccc gagacaatgc caaaaactct ttatacctgc agatgaattc actacgtgca     3360

gaggatacgg ccgtctatta ctgtgctaag gtgtcatatc tcagcaccgc atcctctctg     3420

gactactggg gacaagggac attggttact gtgagctccg cctccaccaa gggcccatcg     3480

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     3540

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     3600

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     3660

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     3720

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3780

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     3840

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     3900

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     3960

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     4020

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     4080

aacaaagccc tcccagcccc tatcgagaaa acaatctcca aagccaaagg gcagccccga     4140

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaagtcagc     4200

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     4260

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     4320

ttcctctact ccaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     4380

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     4440

ccgggcaaat gagtttaaac tccataaagt aggaaacact acactattcc ataaagtagg     4500

aaacactaca tcactccata aagtaggaaa cactacaagt ctccataaag taggaaacac     4560

tacacaattg aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg      4619


<210>  124
<211>  4507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #9 L-IRES-H Antibody expression cassette (w/o ITRs)

<400>  124
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt     1800

gtcacaaact cagacatcca gatgacccaa agcccctcct ctctgtcagc cagtgtgggg     1860

gatcgcgtca caattacttg cagagcttcc cagggaataa ggaactacct cgcgtggtat     1920

cagcaaaagc ctgggaaagc gccaaagttg cttatctatg ccgccagcac tctgcagtca     1980

ggtgttccta gtagattctc tggcagtgga agcgggactg actttacatt aactatttcc     2040

tctctgcaac ctgaggatgt ggccacctat tactgtcagc ggtataatcg cgcaccttac     2100

acatttggcc aaggtaccaa agtagaaatc aagcggactg tggctgcacc atctgtcttc     2160

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     2220

aataacttct atcccagaga ggccaaagta cagtggaagg tggataatgc cctccaaagt     2280

ggcaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     2340

agcaccctga ccctgagcaa agcagactat gagaaacaca aagtctacgc gtgtgaagtc     2400

acccatcagg gcctgagctc cccagtcaca aagagcttca acaggggaga gtgttgagcc     2460

cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg     2520

cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga     2580

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa     2640

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa     2700

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct     2760

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg     2820

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg     2880

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca     2940

catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg     3000

acgtggtttt cctttgaaaa acacgatgat aatatggcca caatgcacag ctcagcactg     3060

ctctgttgcc tggtcctcct gactggggtg agggctgagg tgcagctggt tgaaagcggc     3120

ggagggcttg ttcaacctgg tagatccttg agactttctt gcgccgcttc tggcttcacc     3180

tttgatgatt atgcaatgca ctgggtgagg caggcgcctg gaaaggggct ggagtgggta     3240

tcagccatca catggaacag tggccatatt gactatgctg atagtgtgga aggtagattc     3300

actatatccc gcgacaatgc caaaaactct ttatacctgc agatgaattc actacgcgca     3360

gaggatactg cggtctatta ctgtgctaag gtgtcatatc tcagcaccgc atcctctctg     3420

gactactggg gacaagggac attggttact gtgagctccg cctccaccaa gggcccaagt     3480

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     3540

ctggtcaagg actacttccc tgaacctgtg acagtgtctt ggaactcagg cgccctgacc     3600

agcggagtgc acaccttccc agctgtccta cagtcctcag gactctactc cctcagcagt     3660

gtggtgactg tgccctccag cagcttgggc acccagacct acatctgcaa tgtgaatcac     3720

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3780

acatgcccac cttgcccagc acctgaactc ctggggggac catcagtctt cctcttcccc     3840

ccaaaaccca aggacaccct catgatctcc cgcacccctg aggtcacatg tgtggtggtg     3900

gatgtgagcc atgaagaccc tgaggtcaag ttcaactggt atgtggatgg tgtggaggtg     3960

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacatacag agtggtctct     4020

gtcctcactg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     4080

aacaaagccc tcccagcccc tattgagaaa acaatctcca aagccaaagg gcagcccagg     4140

gaaccacagg tgtacaccct gcccccatcc cgcgatgagc tgaccaagaa ccaggtctcc     4200

ctgacctgcc tggtcaaagg cttctatccc agtgacattg ctgtggagtg ggagagcaat     4260

gggcagcctg agaacaacta caagaccaca cctccagtgc tggactctga tggctccttc     4320

ttcctctact ccaagctcac tgtggacaag agcaggtggc agcaggggaa tgtcttctca     4380

tgcagtgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     4440

cctggcaaat gacaattgaa taaaagatct ttattttcat tagatctgtg tgttggtttt     4500

ttgtgtg                                                               4507


<210>  125
<211>  4619
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #10 L-IRES-H-4xmiR142 Antibody expression cassette (w/o ITRs)

<400>  125
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt     1800

gtcacaaact cagacatcca gatgacccaa agcccctcct ctctgtcagc cagtgtgggg     1860

gatcgcgtca caattacttg cagagcttcc cagggaataa ggaactacct cgcgtggtat     1920

cagcaaaagc ctgggaaagc gccaaagttg cttatctatg ccgccagcac tctgcagtca     1980

ggtgttccta gtagattctc tggcagtgga agcgggactg actttacatt aactatttcc     2040

tctctgcaac ctgaggatgt ggccacctat tactgtcagc ggtataatcg cgcaccttac     2100

acatttggcc aaggtaccaa agtagaaatc aagcggactg tggctgcacc atctgtcttc     2160

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     2220

aataacttct atcccagaga ggccaaagta cagtggaagg tggataatgc cctccaaagt     2280

ggcaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     2340

agcaccctga ccctgagcaa agcagactat gagaaacaca aagtctacgc gtgtgaagtc     2400

acccatcagg gcctgagctc cccagtcaca aagagcttca acaggggaga gtgttgagcc     2460

cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg     2520

cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga     2580

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa     2640

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa     2700

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct     2760

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg     2820

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg     2880

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca     2940

catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg     3000

acgtggtttt cctttgaaaa acacgatgat aatatggcca caatgcacag ctcagcactg     3060

ctctgttgcc tggtcctcct gactggggtg agggctgagg tgcagctggt tgaaagcggc     3120

ggagggcttg ttcaacctgg tagatccttg agactttctt gcgccgcttc tggcttcacc     3180

tttgatgatt atgcaatgca ctgggtgagg caggcgcctg gaaaggggct ggagtgggta     3240

tcagccatca catggaacag tggccatatt gactatgctg atagtgtgga aggtagattc     3300

actatatccc gcgacaatgc caaaaactct ttatacctgc agatgaattc actacgcgca     3360

gaggatactg cggtctatta ctgtgctaag gtgtcatatc tcagcaccgc atcctctctg     3420

gactactggg gacaagggac attggttact gtgagctccg cctccaccaa gggcccaagt     3480

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     3540

ctggtcaagg actacttccc tgaacctgtg acagtgtctt ggaactcagg cgccctgacc     3600

agcggagtgc acaccttccc agctgtccta cagtcctcag gactctactc cctcagcagt     3660

gtggtgactg tgccctccag cagcttgggc acccagacct acatctgcaa tgtgaatcac     3720

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3780

acatgcccac cttgcccagc acctgaactc ctggggggac catcagtctt cctcttcccc     3840

ccaaaaccca aggacaccct catgatctcc cgcacccctg aggtcacatg tgtggtggtg     3900

gatgtgagcc atgaagaccc tgaggtcaag ttcaactggt atgtggatgg tgtggaggtg     3960

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacatacag agtggtctct     4020

gtcctcactg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     4080

aacaaagccc tcccagcccc tattgagaaa acaatctcca aagccaaagg gcagcccagg     4140

gaaccacagg tgtacaccct gcccccatcc cgcgatgagc tgaccaagaa ccaggtctcc     4200

ctgacctgcc tggtcaaagg cttctatccc agtgacattg ctgtggagtg ggagagcaat     4260

gggcagcctg agaacaacta caagaccaca cctccagtgc tggactctga tggctccttc     4320

ttcctctact ccaagctcac tgtggacaag agcaggtggc agcaggggaa tgtcttctca     4380

tgcagtgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     4440

cctggcaaat gagtttaaac tccataaagt aggaaacact acactattcc ataaagtagg     4500

aaacactaca tcactccata aagtaggaaa cactacaagt ctccataaag taggaaacac     4560

tacacaattg aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg      4619


<210>  126
<211>  4507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #11 L-IRES-H ORF

<400>  126
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt     1800

gtcacaaact cagacatcca gatgacccaa agcccctcct ctctgtcagc cagtgtgggg     1860

gatagagtca caattacttg cagagcttcc cagggaataa ggaactactt ggcatggtat     1920

cagcaaaagc ctgggaaagc tccaaagttg cttatctatg ctgccagcac tctgcagtca     1980

ggtgttccta gtagattctc aggcagtgga agtgggactg actttacatt aactatttcc     2040

tctctgcaac ctgaggatgt ggccacctat tactgtcaga ggtataatag agcaccttac     2100

acatttggcc aaggtaccaa agtagaaatc aagaggactg tggctgcacc atctgtcttc     2160

atcttccccc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     2220

aataacttct atcccagaga ggccaaagta cagtggaagg tggataatgc cctccaatca     2280

ggcaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     2340

agcaccctga ccctgagcaa agcagactat gagaaacaca aagtctatgc ctgtgaagtc     2400

acccatcagg gcctgagctc cccagtcaca aagagcttca acaggggaga gtgttgagcc     2460

cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg     2520

cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga     2580

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa     2640

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa     2700

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct     2760

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg     2820

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg     2880

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca     2940

catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg     3000

acgtggtttt cctttgaaaa acacgatgat aatatggcca caatgcacag ctcagcactg     3060

ctctgttgcc tggtcctcct gactggggtg agggctgagg tgcagctggt tgaaagtgga     3120

ggagggcttg ttcaacctgg tagatccttg agactttctt gtgctgcttc tggcttcacc     3180

tttgatgatt atgcaatgca ctgggtgagg caggcacctg gaaaggggct ggagtgggta     3240

tcagccatca catggaacag tggccatatt gactatgctg atagtgtgga aggtagattc     3300

actatatcca gagacaatgc caaaaactct ttatacctgc agatgaattc actaagggca     3360

gaggatactg ctgtctatta ctgtgctaag gtatcatatc tcagcacagc atcctctctg     3420

gactactggg gacaagggac attggttact gtgagctctg cctccaccaa gggcccaagt     3480

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcagc cctgggctgc     3540

ctggtcaagg actacttccc tgaacctgtg actgtgtctt ggaactcagg tgccctgacc     3600

agtggagtgc acaccttccc agctgtccta cagtcctcag gactctactc cctgagctct     3660

gtggtgacag tgccctccag cagcttgggc acccagacct acatctgcaa tgtgaatcac     3720

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3780

acatgcccac cttgcccagc acctgaactc ctggggggac catcagtctt cctcttcccc     3840

ccaaaaccca aggacaccct catgatctcc agaacccctg aggtcacatg tgtggtggtg     3900

gatgtgagcc atgaagaccc tgaggtcaag ttcaactggt atgtggatgg tgtggaggtg     3960

cataatgcca agacaaagcc cagggaggag cagtacaaca gcacttacag agtggtcagt     4020

gtcctcacag tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     4080

aacaaagccc tcccagcccc cattgagaaa accatctcca aagccaaagg gcagcccagg     4140

gaaccacagg tgtacaccct gcccccatcc agagatgagc tgaccaagaa ccaggtctcc     4200

ctgacctgcc tggtcaaagg cttctatccc tctgacattg ctgtggagtg ggagagcaat     4260

gggcagccag agaacaacta caagaccact cctcctgtgc tggactctga tggctccttc     4320

ttcctctact ccaagctcac agtggacaag agcaggtggc agcaggggaa tgtcttctca     4380

tgcagtgtga tgcatgaggc tctgcacaac cactacactc agaagagcct ctccctgtct     4440

cctggcaaat gacaattgaa taaaagatct ttattttcat tagatctgtg tgttggtttt     4500

ttgtgtg                                                               4507


<210>  127
<211>  4619
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #12 L-IRES-H-4xmiR142 Antibody expression cassette (w/o ITRs)

<400>  127
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt     1800

gtcacaaact cagacatcca gatgacccaa agcccctcct ctctgtcagc cagtgtgggg     1860

gatagagtca caattacttg cagagcttcc cagggaataa ggaactactt ggcatggtat     1920

cagcaaaagc ctgggaaagc tccaaagttg cttatctatg ctgccagcac tctgcagtca     1980

ggtgttccta gtagattctc aggcagtgga agtgggactg actttacatt aactatttcc     2040

tctctgcaac ctgaggatgt ggccacctat tactgtcaga ggtataatag agcaccttac     2100

acatttggcc aaggtaccaa agtagaaatc aagaggactg tggctgcacc atctgtcttc     2160

atcttccccc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     2220

aataacttct atcccagaga ggccaaagta cagtggaagg tggataatgc cctccaatca     2280

ggcaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     2340

agcaccctga ccctgagcaa agcagactat gagaaacaca aagtctatgc ctgtgaagtc     2400

acccatcagg gcctgagctc cccagtcaca aagagcttca acaggggaga gtgttgagcc     2460

cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg     2520

cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga     2580

aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa     2640

tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa     2700

caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct     2760

gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg     2820

ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg     2880

ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca     2940

catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg     3000

acgtggtttt cctttgaaaa acacgatgat aatatggcca caatgcacag ctcagcactg     3060

ctctgttgcc tggtcctcct gactggggtg agggctgagg tgcagctggt tgaaagtgga     3120

ggagggcttg ttcaacctgg tagatccttg agactttctt gtgctgcttc tggcttcacc     3180

tttgatgatt atgcaatgca ctgggtgagg caggcacctg gaaaggggct ggagtgggta     3240

tcagccatca catggaacag tggccatatt gactatgctg atagtgtgga aggtagattc     3300

actatatcca gagacaatgc caaaaactct ttatacctgc agatgaattc actaagggca     3360

gaggatactg ctgtctatta ctgtgctaag gtatcatatc tcagcacagc atcctctctg     3420

gactactggg gacaagggac attggttact gtgagctctg cctccaccaa gggcccaagt     3480

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcagc cctgggctgc     3540

ctggtcaagg actacttccc tgaacctgtg actgtgtctt ggaactcagg tgccctgacc     3600

agtggagtgc acaccttccc agctgtccta cagtcctcag gactctactc cctgagctct     3660

gtggtgacag tgccctccag cagcttgggc acccagacct acatctgcaa tgtgaatcac     3720

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3780

acatgcccac cttgcccagc acctgaactc ctggggggac catcagtctt cctcttcccc     3840

ccaaaaccca aggacaccct catgatctcc agaacccctg aggtcacatg tgtggtggtg     3900

gatgtgagcc atgaagaccc tgaggtcaag ttcaactggt atgtggatgg tgtggaggtg     3960

cataatgcca agacaaagcc cagggaggag cagtacaaca gcacttacag agtggtcagt     4020

gtcctcacag tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     4080

aacaaagccc tcccagcccc cattgagaaa accatctcca aagccaaagg gcagcccagg     4140

gaaccacagg tgtacaccct gcccccatcc agagatgagc tgaccaagaa ccaggtctcc     4200

ctgacctgcc tggtcaaagg cttctatccc tctgacattg ctgtggagtg ggagagcaat     4260

gggcagccag agaacaacta caagaccact cctcctgtgc tggactctga tggctccttc     4320

ttcctctact ccaagctcac agtggacaag agcaggtggc agcaggggaa tgtcttctca     4380

tgcagtgtga tgcatgaggc tctgcacaac cactacactc agaagagcct ctccctgtct     4440

cctggcaaat gagtttaaac tccataaagt aggaaacact acactattcc ataaagtagg     4500

aaacactaca tcactccata aagtaggaaa cactacaagt ctccataaag taggaaacac     4560

tacacaattg aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg      4619


<210>  128
<211>  3872
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #13 DP-HL-opposite Antibody expression cassette (w/o ITRs)

<400>  128
cacacaaaaa accaacacac agatctaatg aaaataaaga tcttttattc ctaggtcatt       60

tgcccggaga cagggagagg ctcttctgcg tgtagtggtt gtgcagagcc tcatgcatca      120

cggagcatga gaagacgttc ccctgctgcc acctgctctt gtccacggtg agcttggagt      180

agaggaagaa ggagccgtcg gagtccagca cgggaggcgt ggtcttgtag ttgttctccg      240

gctgcccatt gctctcccac tccacggcga tgtcgctggg atagaagcct ttgaccaggc      300

aggtcaggct gacttggttc ttggtcagct catcccggga tgggggcagg gtgtacacct      360

gtggttctcg gggctgccct ttggctttgg agattgtttt ctcgataggg gctgggaggg      420

ctttgttgga gaccttgcac ttgtactcct tgccattcag ccagtcctgg tgcaggacgg      480

tgaggacgct gaccacacgg tacgtgctgt tgtactgctc ctcccgcggc tttgtcttgg      540

cattatgcac ctccacgccg tccacgtacc agttgaactt gacctcaggg tcttcgtggc      600

tcacgtccac caccacgcat gtgacctcag gggtccggga gatcatgagg gtgtccttgg      660

gttttggggg gaagaggaag actgacggtc cccccaggag ttcaggtgct gggcacggtg      720

ggcatgtgtg agttttgtca caagatttgg gctcaacttt cttgtccacc ttggtgttgc      780

tgggcttgtg attcacgttg cagatgtagg tctgggtgcc caagctgctg gagggcacgg      840

tcaccacgct gctgagggag tagagtcctg aggactgtag gacagccggg aaggtgtgca      900

cgccgctggt cagggcgcct gagttccacg acaccgtcac cggttcgggg aagtagtcct      960

tgaccaggca gcccagggcc gctgtgcccc cagaggtgct cttggaggag ggtgccaggg     1020

ggaagaccga tgggcccttg gtggaggcgg agctcacagt aaccaatgtc ccttgtcccc     1080

agtagtccag agaggatgcg gtgctgagat atgacacctt agcacagtaa tagacggccg     1140

tatcctctgc acgtagtgaa ttcatctgca ggtataaaga gtttttggca ttgtctcggg     1200

atatagtgaa gcgaccttcc acgctatcag catagtcaat atggcccgag ttccatgtga     1260

tggctgatac ccactccagc ccctttccag gcgcctgcct cacccagtgc attgcgtaat     1320

cgtcaaaggt gaagccagaa gcggcgcaag aaagtctcaa ggaccgaccg ggttgaacga     1380

gccctccgcc gctttcgacc agctgcacct cggccctcac cccagtcagg aggaccaggc     1440

aacagagcag tgctgagctg tgcatggtgg tttaaactag ccttaagagc tgtaattgaa     1500

ctgggagtgg acacctgtgg agagaaaggc aaagtggatg tcagtaagac caataggtgc     1560

ctatcagaaa cgcaagagtc ttctctgtct cgacaagccc agtttctatt ggtctcctta     1620

aacctgtctt gtaaccttga tacttacctg cccagtgcct cacgaccaac ttcgatctgt     1680

aacggcgcag aacagaaaac gaaacaaaga cgtagagttg agcaagcagg gtcaggcaaa     1740

gcgtggagag ccggctgagt ctaggtaggc tccaagggag cgccggacaa aggcccggtc     1800

tcgacctgag ctttaaactt acctagacgg cggacgcagt tcaggaggca ccacaggcgg     1860

gaggcggcag aacgcgactc aaccggcgtg gatggcggcc tcaggtaggg cggcgggcgc     1920

gtgaaggaga gatgcgagcc cctcgaagct tcagctgtgt tctggcggca aacccgttgc     1980

gaaaaagaac gttcacggcg actactgcac ttatatacgg ttctccccca ccctcgggaa     2040

aaaggcggag ccagtacacg acatcacttt cccagtttac cccgcgccac cttctctagg     2100

caccggttca attgccgacc cctcccccca acttctcggg gactgtgggc gatgtgcgct     2160

ctgcccactg acgggcaccg gagcattgat tattgactag ttattaatag taatcaatta     2220

cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg     2280

gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc     2340

ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggactat ttacggtaaa     2400

ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca     2460

atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta     2520

cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt     2580

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg     2640

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca     2700

actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca     2760

gagctcgttt agtgaaccgt cagatcgcct ggagaaggaa ctgaaaaacc agaaagttaa     2820

ctggtaagtt tagtcttttt gtcttttatt tcaggtcccg gatccggtgg tggtgcaaat     2880

caaagaactg ctcctcagtg gatgttgcct ttacttctag gcctgtacgg aagtgttact     2940

tctgctctaa aagctgcgga attgtagccc ggttaattaa gccaccatgt acaggatgca     3000

actcctgtct tgcattgcac taagtcttgc acttgtcaca aactcggaca tccagatgac     3060

ccaaagcccc tcctctctgt cagccagtgt gggcgatcgg gtcacaatta cttgcagagc     3120

ttcgcaggga ataaggaact acctcgcatg gtatcagcaa aagcctggga aagcgccaaa     3180

gttgcttatc tacgccgcca gcacgctgca gtccggtgtt ccgtctcgct tctctggcag     3240

tggaagcggg accgacttta cattaactat ttcctctctg caacccgagg atgtggccac     3300

ctattactgt cagcgatata atcgtgcacc ttacacattc ggccaaggta ccaaagtaga     3360

aatcaagcga actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt     3420

gaaatctgga actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa     3480

agtacagtgg aaggtggata acgccctcca atcgggcaac tcccaggaga gtgtcacaga     3540

gcaggacagc aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga     3600

ctacgagaaa cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt     3660

cacaaagagc ttcaacaggg gagagtgttg agcatgcctg tgccttctag ttgccagcca     3720

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     3780

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     3840

gggggtgggg tggggcagga cagcaagggg ga                                   3872


<210>  129
<211>  3999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #14 DP-HL-same Antibody expression cassette (w/o ITRs)

<400>  129
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      600

agatcgcctg gagaaggaac tgaaaaacca gaaagttaac tggtaagttt agtctttttg      660

tcttttattt caggtcccgg atccggtggt ggtgcaaatc aaagaactgc tcctcagtgg      720

atgttgcctt tacttctagg cctgtacgga agtgttactt ctgctctaaa agctgcggaa      780

ttgtagcccg gttaattaag ccaccatgca cagctcagca ctgctctgtt gcctggtcct      840

cctgactggg gtgagggccg aggtgcagct ggtcgaaagc ggcggagggc tcgttcaacc      900

cggtcggtcc ttgagacttt cttgcgccgc ttctggcttc acctttgacg attacgcaat      960

gcactgggtg aggcaggcgc ctggaaaggg gctggagtgg gtatcagcca tcacatggaa     1020

ctcgggccat attgactatg ctgatagcgt ggaaggtcgc ttcactatat cccgagacaa     1080

tgccaaaaac tctttatacc tgcagatgaa ttcactacgt gcagaggata cggccgtcta     1140

ttactgtgct aaggtgtcat atctcagcac cgcatcctct ctggactact ggggacaagg     1200

gacattggtt actgtgagct ccgcctccac caagggccca tcggtcttcc ccctggcacc     1260

ctcctccaag agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt     1320

ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt     1380

cccggctgtc ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc     1440

cagcagcttg ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa     1500

ggtggacaag aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc     1560

agcacctgaa ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac     1620

cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga     1680

ccctgaggtc aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa     1740

gccgcgggag gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca     1800

ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc     1860

ccctatcgag aaaacaatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac     1920

cctgccccca tcccgggatg agctgaccaa gaaccaagtc agcctgacct gcctggtcaa     1980

aggcttctat cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa     2040

ctacaagacc acgcctcccg tgctggactc cgacggctcc ttcttcctct actccaagct     2100

caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga     2160

ggctctgcac aaccactaca cgcagaagag cctctccctg tctccgggca aatgagcatg     2220

cctgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     2280

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     2340

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     2400

tctcagaact aacatacgct ctccatcaaa acaaaacgaa acaaaacaaa ctagcaaaat     2460

aggctgtccc cagtgcaagt gcaggtgcca gaacatttct ctatcgaagg atctgcgatc     2520

gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg     2580

gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg     2640

atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag     2700

tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag ctgaagcttc     2760

gaggggctcg catctctcct tcacgcgccc gccgccctac ctgaggccgc catccacgcc     2820

ggttgagtcg cgttctgccg cctcccgcct gtggtgcctc ctgaactgcg tccgccgtct     2880

aggtaagttt aaagctcagg tcgagaccgg gcctttgtcc ggcgctccct tggagcctac     2940

ctagactcag ccggctctcc acgctttgcc tgaccctgct tgctcaactc tacgtctttg     3000

tttcgttttc tgttctgcgc cgttacagat cgaagttggt cgtgaggcac tgggcaggta     3060

agtatcaagg ttacaagaca ggtttaagga gaccaataga aactgggctt gtcgagacag     3120

agaagactct tgcgtttctg ataggcacct attggtctta ctgacatcca ctttgccttt     3180

ctctccacag gtgtccactc ccagttcaat tacagctctt aaggctagtt taaaccacca     3240

tgtacaggat gcaactcctg tcttgcattg cactaagtct tgcacttgtc acaaactcgg     3300

acatccagat gacccaaagc ccctcctctc tgtcagccag tgtgggcgat cgggtcacaa     3360

ttacttgcag agcttcgcag ggaataagga actacctcgc atggtatcag caaaagcctg     3420

ggaaagcgcc aaagttgctt atctacgccg ccagcacgct gcagtccggt gttccgtctc     3480

gcttctctgg cagtggaagc gggaccgact ttacattaac tatttcctct ctgcaacccg     3540

aggatgtggc cacctattac tgtcagcgat ataatcgtgc accttacaca ttcggccaag     3600

gtaccaaagt agaaatcaag cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat     3660

ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat aacttctatc     3720

ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggc aactcccagg     3780

agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc accctgacgc     3840

tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc catcagggcc     3900

tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttgacctagg aataaaagat     3960

ctttattttc attagatctg tgtgttggtt ttttgtgtg                            3999


<210>  130
<211>  3872
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #15 DP-LH-opposite Antibody expression cassette (w/o ITRs)

<400>  130
cacacaaaaa accaacacac agatctaatg aaaataaaga tcttttattc ctaggtcaac       60

actctcccct gttgaagctc tttgtgacgg gcgagctcag gccctgatgg gtgacttcgc      120

aggcgtagac tttgtgtttc tcgtagtctg ctttgctcag cgtcagggtg ctgctgaggc      180

tgtaggtgct gtccttgctg tcctgctctg tgacactctc ctgggagttg cccgattgga      240

gggcgttatc caccttccac tgtactttgg cctctctggg atagaagtta ttcagcaggc      300

acacaacaga ggcagttcca gatttcaact gctcatcaga tggcgggaag atgaagacag      360

atggtgcagc cacagttcgc ttgatttcta ctttggtacc ttggccgaat gtgtaaggtg      420

cacgattata tcgctgacag taataggtgg ccacatcctc gggttgcaga gaggaaatag      480

ttaatgtaaa gtcggtcccg cttccactgc cagagaagcg agacggaaca ccggactgca      540

gcgtgctggc ggcgtagata agcaactttg gcgctttccc aggcttttgc tgataccatg      600

cgaggtagtt ccttattccc tgcgaagctc tgcaagtaat tgtgacccga tcgcccacac      660

tggctgacag agaggagggg ctttgggtca tctggatgtc cgagtttgtg acaagtgcaa      720

gacttagtgc aatgcaagac aggagttgca tcctgtacat ggtggtttaa actagcctta      780

agagctgtaa ttgaactggg agtggacacc tgtggagaga aaggcaaagt ggatgtcagt      840

aagaccaata ggtgcctatc agaaacgcaa gagtcttctc tgtctcgaca agcccagttt      900

ctattggtct ccttaaacct gtcttgtaac cttgatactt acctgcccag tgcctcacga      960

ccaacttcga tctgtaacgg cgcagaacag aaaacgaaac aaagacgtag agttgagcaa     1020

gcagggtcag gcaaagcgtg gagagccggc tgagtctagg taggctccaa gggagcgccg     1080

gacaaaggcc cggtctcgac ctgagcttta aacttaccta gacggcggac gcagttcagg     1140

aggcaccaca ggcgggaggc ggcagaacgc gactcaaccg gcgtggatgg cggcctcagg     1200

tagggcggcg ggcgcgtgaa ggagagatgc gagcccctcg aagcttcagc tgtgttctgg     1260

cggcaaaccc gttgcgaaaa agaacgttca cggcgactac tgcacttata tacggttctc     1320

ccccaccctc gggaaaaagg cggagccagt acacgacatc actttcccag tttaccccgc     1380

gccaccttct ctaggcaccg gttcaattgc cgacccctcc ccccaacttc tcggggactg     1440

tgggcgatgt gcgctctgcc cactgacggg caccggagca ttgattattg actagttatt     1500

aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat     1560

aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa     1620

taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg     1680

actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc     1740

cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct     1800

tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga     1860

tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa     1920

gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc     1980

caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg     2040

aggtctatat aagcagagct cgtttagtga accgtcagat cgcctggaga aggaactgaa     2100

aaaccagaaa gttaactggt aagtttagtc tttttgtctt ttatttcagg tcccggatcc     2160

ggtggtggtg caaatcaaag aactgctcct cagtggatgt tgcctttact tctaggcctg     2220

tacggaagtg ttacttctgc tctaaaagct gcggaattgt agcccggtta attaagccac     2280

catgcacagc tcagcactgc tctgttgcct ggtcctcctg actggggtga gggccgaggt     2340

gcagctggtc gaaagcggcg gagggctcgt tcaacccggt cggtccttga gactttcttg     2400

cgccgcttct ggcttcacct ttgacgatta cgcaatgcac tgggtgaggc aggcgcctgg     2460

aaaggggctg gagtgggtat cagccatcac atggaactcg ggccatattg actatgctga     2520

tagcgtggaa ggtcgcttca ctatatcccg agacaatgcc aaaaactctt tatacctgca     2580

gatgaattca ctacgtgcag aggatacggc cgtctattac tgtgctaagg tgtcatatct     2640

cagcaccgca tcctctctgg actactgggg acaagggaca ttggttactg tgagctccgc     2700

ctccaccaag ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg     2760

cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg     2820

gaactcaggc gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg     2880

actctactcc ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta     2940

catctgcaac gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa     3000

atcttgtgac aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc     3060

gtcagtcttc ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga     3120

ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta     3180

cgtggacggc gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag     3240

cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga     3300

gtacaagtgc aaggtctcca acaaagccct cccagcccct atcgagaaaa caatctccaa     3360

agccaaaggg cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct     3420

gaccaagaac caagtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc     3480

cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct     3540

ggactccgac ggctccttct tcctctactc caagctcacc gtggacaaga gcaggtggca     3600

gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca     3660

gaagagcctc tccctgtctc cgggcaaatg agcatgcctg tgccttctag ttgccagcca     3720

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     3780

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     3840

gggggtgggg tggggcagga cagcaagggg ga                                   3872


<210>  131
<211>  3999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #16 DP-LH-Same Antibody expression cassette (w/o ITRs)

<400>  131
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      600

agatcgcctg gagaaggaac tgaaaaacca gaaagttaac tggtaagttt agtctttttg      660

tcttttattt caggtcccgg atccggtggt ggtgcaaatc aaagaactgc tcctcagtgg      720

atgttgcctt tacttctagg cctgtacgga agtgttactt ctgctctaaa agctgcggaa      780

ttgtagcccg gttaattaag ccaccatgta caggatgcaa ctcctgtctt gcattgcact      840

aagtcttgca cttgtcacaa actcggacat ccagatgacc caaagcccct cctctctgtc      900

agccagtgtg ggcgatcggg tcacaattac ttgcagagct tcgcagggaa taaggaacta      960

cctcgcatgg tatcagcaaa agcctgggaa agcgccaaag ttgcttatct acgccgccag     1020

cacgctgcag tccggtgttc cgtctcgctt ctctggcagt ggaagcggga ccgactttac     1080

attaactatt tcctctctgc aacccgagga tgtggccacc tattactgtc agcgatataa     1140

tcgtgcacct tacacattcg gccaaggtac caaagtagaa atcaagcgaa ctgtggctgc     1200

accatctgtc ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt     1260

tgtgtgcctg ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa     1320

cgccctccaa tcgggcaact cccaggagag tgtcacagag caggacagca aggacagcac     1380

ctacagcctc agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta     1440

cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg     1500

agagtgttga gcatgcctgt gccttctagt tgccagccat ctgttgtttg cccctccccc     1560

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     1620

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     1680

agcaaggggg aggattctca gaactaacat acgctctcca tcaaaacaaa acgaaacaaa     1740

acaaactagc aaaataggct gtccccagtg caagtgcagg tgccagaaca tttctctatc     1800

gaaggatctg cgatcgctcc ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc     1860

ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg tggcgcgggg     1920

taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt gggggagaac     1980

cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt gccgccagaa     2040

cacagctgaa gcttcgaggg gctcgcatct ctccttcacg cgcccgccgc cctacctgag     2100

gccgccatcc acgccggttg agtcgcgttc tgccgcctcc cgcctgtggt gcctcctgaa     2160

ctgcgtccgc cgtctaggta agtttaaagc tcaggtcgag accgggcctt tgtccggcgc     2220

tcccttggag cctacctaga ctcagccggc tctccacgct ttgcctgacc ctgcttgctc     2280

aactctacgt ctttgtttcg ttttctgttc tgcgccgtta cagatcgaag ttggtcgtga     2340

ggcactgggc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     2400

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     2460

atccactttg cctttctctc cacaggtgtc cactcccagt tcaattacag ctcttaaggc     2520

tagtttaaac caccatgcac agctcagcac tgctctgttg cctggtcctc ctgactgggg     2580

tgagggccga ggtgcagctg gtcgaaagcg gcggagggct cgttcaaccc ggtcggtcct     2640

tgagactttc ttgcgccgct tctggcttca cctttgacga ttacgcaatg cactgggtga     2700

ggcaggcgcc tggaaagggg ctggagtggg tatcagccat cacatggaac tcgggccata     2760

ttgactatgc tgatagcgtg gaaggtcgct tcactatatc ccgagacaat gccaaaaact     2820

ctttatacct gcagatgaat tcactacgtg cagaggatac ggccgtctat tactgtgcta     2880

aggtgtcata tctcagcacc gcatcctctc tggactactg gggacaaggg acattggtta     2940

ctgtgagctc cgcctccacc aagggcccat cggtcttccc cctggcaccc tcctccaaga     3000

gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc cccgaaccgg     3060

tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc     3120

tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc agcagcttgg     3180

gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag gtggacaaga     3240

aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca gcacctgaac     3300

tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct     3360

cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca     3420

agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag ccgcgggagg     3480

agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac caggactggc     3540

tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cctatcgaga     3600

aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat     3660

cccgggatga gctgaccaag aaccaagtca gcctgacctg cctggtcaaa ggcttctatc     3720

ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca     3780

cgcctcccgt gctggactcc gacggctcct tcttcctcta ctccaagctc accgtggaca     3840

agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca     3900

accactacac gcagaagagc ctctccctgt ctccgggcaa atgacctagg aataaaagat     3960

ctttattttc attagatctg tgtgttggtt ttttgtgtg                            3999


<210>  132
<211>  4147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #17 Dual promoter-L-H (including ITRs)

<400>  132
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gaaggaactg aaaaaccaga      780

aagttaactg gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg      840

tgcaaatcaa agaactgctc ctcagtggat gttgccttta cttctaggcc tgtacggaag      900

tgttacttct gctctaaaag ctgcggaatt gtagcccggt taattaagcc accatgtaca      960

ggatgcaact cctgtcttgc attgcactaa gtcttgcact tgtcacaaac tcagacatcc     1020

agatgaccca aagcccctcc tctctgtcag ccagtgtggg ggatagagtc acaattactt     1080

gcagagcttc ccagggaata aggaactact tggcatggta tcagcaaaag cctgggaaag     1140

ctccaaagtt gcttatctat gctgccagca ctctgcagtc aggtgttcct agtagattct     1200

caggcagtgg aagtgggact gactttacat taactatttc ctctctgcaa cctgaggatg     1260

tggccaccta ttactgtcag aggtataata gagcacctta cacatttggc caaggtacca     1320

aagtagaaat caagaggact gtggctgcac catctgtctt catcttcccc ccatctgatg     1380

agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc tatcccagag     1440

aggccaaagt acagtggaag gtggataatg ccctccaatc aggcaactcc caggagagtg     1500

tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg accctgagca     1560

aagcagacta tgagaaacac aaagtctatg cctgtgaagt cacccatcag ggcctgagct     1620

ccccagtcac aaagagcttc aacaggggag agtgttgagc atgcctgtgc cttctagttg     1680

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     1740

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     1800

tattctgggg ggtggggtgg ggcaggacag caagggggag gattctcaga actaacatac     1860

gctctccatc aaaacaaaac gaaacaaaac aaactagcaa aataggctgt ccccagtgca     1920

agtgcaggtg ccagaacatt tctctatcga aggatctgcg atcgctccgg tgcccgtcag     1980

tgggcagagc gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga     2040

accggtgcct agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc     2100

cgcctttttc ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt     2160

ctttttcgca acgggtttgc cgccagaaca cagctgaagc ttcgaggggc tcgcatctct     2220

ccttcacgcg cccgccgccc tacctgaggc cgccatccac gccggttgag tcgcgttctg     2280

ccgcctcccg cctgtggtgc ctcctgaact gcgtccgccg tctaggtaag tttaaagctc     2340

aggtcgagac cgggcctttg tccggcgctc ccttggagcc tacctagact cagccggctc     2400

tccacgcttt gcctgaccct gcttgctcaa ctctacgtct ttgtttcgtt ttctgttctg     2460

cgccgttaca gatcgaagtt ggtcgtgagg cactgggcag gtaagtatca aggttacaag     2520

acaggtttaa ggagaccaat agaaactggg cttgtcgaga cagagaagac tcttgcgttt     2580

ctgataggca cctattggtc ttactgacat ccactttgcc tttctctcca caggtgtcca     2640

ctcccagttc aattacagct cttaaggcta gtttaaacca ccatgcacag ctcagcactg     2700

ctctgttgcc tggtcctcct gactggggtg agggctgagg tgcagctggt tgaaagtgga     2760

ggagggcttg ttcaacctgg tagatccttg agactttctt gtgctgcttc tggcttcacc     2820

tttgatgatt atgcaatgca ctgggtgagg caggcacctg gaaaggggct ggagtgggta     2880

tcagccatca catggaacag tggccatatt gactatgctg atagtgtgga aggtagattc     2940

actatatcca gagacaatgc caaaaactct ttatacctgc agatgaattc actaagggca     3000

gaggatactg ctgtctatta ctgtgctaag gtatcatatc tcagcacagc atcctctctg     3060

gactactggg gacaagggac attggttact gtgagctctg cctccaccaa gggcccaagt     3120

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcagc cctgggctgc     3180

ctggtcaagg actacttccc tgaacctgtg actgtgtctt ggaactcagg tgccctgacc     3240

agtggagtgc acaccttccc agctgtccta cagtcctcag gactctactc cctgagctct     3300

gtggtgacag tgccctccag cagcttgggc acccagacct acatctgcaa tgtgaatcac     3360

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3420

acatgcccac cttgcccagc acctgaactc ctggggggac catcagtctt cctcttcccc     3480

ccaaaaccca aggacaccct catgatctcc agaacccctg aggtcacatg tgtggtggtg     3540

gatgtgagcc atgaagaccc tgaggtcaag ttcaactggt atgtggatgg tgtggaggtg     3600

cataatgcca agacaaagcc cagggaggag cagtacaaca gcacttacag agtggtcagt     3660

gtcctcacag tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     3720

aacaaagccc tcccagcccc cattgagaaa accatctcca aagccaaagg gcagcccagg     3780

gaaccacagg tgtacaccct gcccccatcc agagatgagc tgaccaagaa ccaggtctcc     3840

ctgacctgcc tggtcaaagg cttctatccc tctgacattg ctgtggagtg ggagagcaat     3900

gggcagccag agaacaacta caagaccact cctcctgtgc tggactctga tggctccttc     3960

ttcctctact ccaagctcac agtggacaag agcaggtggc agcaggggaa tgtcttctca     4020

tgcagtgtga tgcatgaggc tctgcacaac cactacactc agaagagcct ctccctgtct     4080

cctggcaaat gacctaggaa taaaagatct ttattttcat tagatctgtg tgttggtttt     4140

ttgtgtg                                                               4147


<210>  133
<211>  3999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #17 Dual promoter-L-H Antibody expression cassette (w/o ITRs)

<400>  133
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      600

agatcgcctg gagaaggaac tgaaaaacca gaaagttaac tggtaagttt agtctttttg      660

tcttttattt caggtcccgg atccggtggt ggtgcaaatc aaagaactgc tcctcagtgg      720

atgttgcctt tacttctagg cctgtacgga agtgttactt ctgctctaaa agctgcggaa      780

ttgtagcccg gttaattaag ccaccatgta caggatgcaa ctcctgtctt gcattgcact      840

aagtcttgca cttgtcacaa actcagacat ccagatgacc caaagcccct cctctctgtc      900

agccagtgtg ggggatagag tcacaattac ttgcagagct tcccagggaa taaggaacta      960

cttggcatgg tatcagcaaa agcctgggaa agctccaaag ttgcttatct atgctgccag     1020

cactctgcag tcaggtgttc ctagtagatt ctcaggcagt ggaagtggga ctgactttac     1080

attaactatt tcctctctgc aacctgagga tgtggccacc tattactgtc agaggtataa     1140

tagagcacct tacacatttg gccaaggtac caaagtagaa atcaagagga ctgtggctgc     1200

accatctgtc ttcatcttcc ccccatctga tgagcagttg aaatctggaa ctgcctctgt     1260

tgtgtgcctg ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa     1320

tgccctccaa tcaggcaact cccaggagag tgtcacagag caggacagca aggacagcac     1380

ctacagcctc agcagcaccc tgaccctgag caaagcagac tatgagaaac acaaagtcta     1440

tgcctgtgaa gtcacccatc agggcctgag ctccccagtc acaaagagct tcaacagggg     1500

agagtgttga gcatgcctgt gccttctagt tgccagccat ctgttgtttg cccctccccc     1560

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     1620

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     1680

agcaaggggg aggattctca gaactaacat acgctctcca tcaaaacaaa acgaaacaaa     1740

acaaactagc aaaataggct gtccccagtg caagtgcagg tgccagaaca tttctctatc     1800

gaaggatctg cgatcgctcc ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc     1860

ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg tggcgcgggg     1920

taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt gggggagaac     1980

cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt gccgccagaa     2040

cacagctgaa gcttcgaggg gctcgcatct ctccttcacg cgcccgccgc cctacctgag     2100

gccgccatcc acgccggttg agtcgcgttc tgccgcctcc cgcctgtggt gcctcctgaa     2160

ctgcgtccgc cgtctaggta agtttaaagc tcaggtcgag accgggcctt tgtccggcgc     2220

tcccttggag cctacctaga ctcagccggc tctccacgct ttgcctgacc ctgcttgctc     2280

aactctacgt ctttgtttcg ttttctgttc tgcgccgtta cagatcgaag ttggtcgtga     2340

ggcactgggc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     2400

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     2460

atccactttg cctttctctc cacaggtgtc cactcccagt tcaattacag ctcttaaggc     2520

tagtttaaac caccatgcac agctcagcac tgctctgttg cctggtcctc ctgactgggg     2580

tgagggctga ggtgcagctg gttgaaagtg gaggagggct tgttcaacct ggtagatcct     2640

tgagactttc ttgtgctgct tctggcttca cctttgatga ttatgcaatg cactgggtga     2700

ggcaggcacc tggaaagggg ctggagtggg tatcagccat cacatggaac agtggccata     2760

ttgactatgc tgatagtgtg gaaggtagat tcactatatc cagagacaat gccaaaaact     2820

ctttatacct gcagatgaat tcactaaggg cagaggatac tgctgtctat tactgtgcta     2880

aggtatcata tctcagcaca gcatcctctc tggactactg gggacaaggg acattggtta     2940

ctgtgagctc tgcctccacc aagggcccaa gtgtcttccc cctggcaccc tcctccaaga     3000

gcacctctgg gggcacagca gccctgggct gcctggtcaa ggactacttc cctgaacctg     3060

tgactgtgtc ttggaactca ggtgccctga ccagtggagt gcacaccttc ccagctgtcc     3120

tacagtcctc aggactctac tccctgagct ctgtggtgac agtgccctcc agcagcttgg     3180

gcacccagac ctacatctgc aatgtgaatc acaagcccag caacaccaag gtggacaaga     3240

aagttgagcc caaatcttgt gacaaaactc acacatgccc accttgccca gcacctgaac     3300

tcctgggggg accatcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct     3360

ccagaacccc tgaggtcaca tgtgtggtgg tggatgtgag ccatgaagac cctgaggtca     3420

agttcaactg gtatgtggat ggtgtggagg tgcataatgc caagacaaag cccagggagg     3480

agcagtacaa cagcacttac agagtggtca gtgtcctcac agtcctgcac caggactggc     3540

tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cccattgaga     3600

aaaccatctc caaagccaaa gggcagccca gggaaccaca ggtgtacacc ctgcccccat     3660

ccagagatga gctgaccaag aaccaggtct ccctgacctg cctggtcaaa ggcttctatc     3720

cctctgacat tgctgtggag tgggagagca atgggcagcc agagaacaac tacaagacca     3780

ctcctcctgt gctggactct gatggctcct tcttcctcta ctccaagctc acagtggaca     3840

agagcaggtg gcagcagggg aatgtcttct catgcagtgt gatgcatgag gctctgcaca     3900

accactacac tcagaagagc ctctccctgt ctcctggcaa atgacctagg aataaaagat     3960

ctttattttc attagatctg tgtgttggtt ttttgtgtg                            3999


<210>  134
<211>  4485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #18 Native adalimumab H-F2A-L (including ITRs)

<400>  134
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc cgaggtgcag ctggtcgaaa gcggcggagg     1980

gctcgttcaa cccggtcggt ccttgagact ttcttgcgcc gcttctggct tcacctttga     2040

cgattacgca atgcactggg tgaggcaggc gcctggaaag gggctggagt gggtatcagc     2100

catcacatgg aactcgggcc atattgacta tgctgatagc gtggaaggtc gcttcactat     2160

atcccgagac aatgccaaaa actctttata cctgcagatg aattcactac gtgcagagga     2220

tacggccgtc tattactgtg ctaaggtgtc atatctcagc accgcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctccgcctcc accaagggcc catcggtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     2400

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     2460

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2520

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2760

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2820

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2880

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccctatcg agaaaacaat ctccaaagcc aaagggcagc cccgagaacc     3000

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccaag tcagcctgac     3060

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     3120

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     3180

ctactccaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     3240

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     3300

taaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca attacttgca gagcttcgca     3540

gggaataagg aactacctcg catggtatca gcaaaagcct gggaaagcgc caaagttgct     3600

tatctacgcc gccagcacgc tgcagtccgg tgttccgtct cgcttctctg gcagtggaag     3660

cgggaccgac tttacattaa ctatttcctc tctgcaaccc gaggatgtgg ccacctatta     3720

ctgtcagcga tataatcgtg caccttacac attcggccaa ggtaccaaag tagaaatcaa     3780

gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataacgccc tccaatcggg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga     4020

gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa     4080

gagcttcaac aggggagagt gttgacaatt gctgtgcctt ctagttgcca gccatctgtt     4140

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     4200

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     4260

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     4320

gcggtgggct ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc     4380

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4440

cccgggcggc ctcagtgagc gagcgagcgc gcagctgcag atctg                     4485


<210>  135
<211>  4187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #18 Native adalimumab H-F2A-L Antibody expression cassette 
       (w/o ITRs)

<400>  135
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      540

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      600

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      660

agtcgctgcg cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      720

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      780

gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc tgcgtgaaag      840

ccttgagggg ctccgggagg gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt      900

gtgtgtgtgc gtggggagcg ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg      960

cgggcgcggc gcggggcttt gtgcgctccg cagtgtgcgc gagaggagcg cggccggggg     1020

cggtgccacg cggtgcgggg ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg     1080

cgtggggggg gtgagcaggg ggtgtgggcg cggcggtcgg gctgtaaccc ccccctgcac     1140

ccccctcccc gagttgctga gcacggcccg gcttcgggtg cggggctccg tgcggggcgt     1200

ggcgcggggc tcgccgtgcc gggcgggggg tggcggcggg tgggggtgcc gggcggggcg     1260

gggccgcctc gggccgggga gggctcgggg gaggggcgcg gcggcccccg gagcgccggc     1320

ggctgtcgag gcgcggcgag ccgcagccat tgccttttat ggtaatcgtg cgagagggcg     1380

cagggacttc ctttgtccca aatctgtgcg gagccgaaat ctgggaggcg ccgccgcacc     1440

ccctctagcg ggcgcggggc gaagcggtgc ggcgccggca ggaaggaaat gggcggggag     1500

ggccttcgtg cgtcgccgcg ccgccgtccc cttctccctc tccagcctcg gggctgtccg     1560

cggggggacg gctgccttcg ggggggacgg ggcagggcgg ggttcggctt ctggcgtgtg     1620

accggcggtc tagactctgc taaccatgtt catgccttct tctctttcct acagctcctg     1680

ggcaacgtgc tggttgttgt gctgtctcat cattttggca aagaattcaa gcttccagct     1740

agcgccacca tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg     1800

gccgaggtgc agctggtcga aagcggcgga gggctcgttc aacccggtcg gtccttgaga     1860

ctttcttgcg ccgcttctgg cttcaccttt gacgattacg caatgcactg ggtgaggcag     1920

gcgcctggaa aggggctgga gtgggtatca gccatcacat ggaactcggg ccatattgac     1980

tatgctgata gcgtggaagg tcgcttcact atatcccgag acaatgccaa aaactcttta     2040

tacctgcaga tgaattcact acgtgcagag gatacggccg tctattactg tgctaaggtg     2100

tcatatctca gcaccgcatc ctctctggac tactggggac aagggacatt ggttactgtg     2160

agctccgcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc     2220

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg     2280

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag     2340

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc     2400

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt     2460

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     2520

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     2580

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     2640

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     2700

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     2760

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccctat cgagaaaaca     2820

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     2880

gatgagctga ccaagaacca agtcagcctg acctgcctgg tcaaaggctt ctatcccagc     2940

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     3000

cccgtgctgg actccgacgg ctccttcttc ctctactcca agctcaccgt ggacaagagc     3060

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     3120

tacacgcaga agagcctctc cctgtctccg ggtaaaagaa agagaaggag tggctcagga     3180

gcccctgtga aacagaccct gaactttgac ctcttgaagc ttgctgggga tgtggagtct     3240

aatcctggtc caatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt     3300

gtcacaaact cggacatcca gatgacccaa agcccctcct ctctgtcagc cagtgtgggc     3360

gatcgggtca caattacttg cagagcttcg cagggaataa ggaactacct cgcatggtat     3420

cagcaaaagc ctgggaaagc gccaaagttg cttatctacg ccgccagcac gctgcagtcc     3480

ggtgttccgt ctcgcttctc tggcagtgga agcgggaccg actttacatt aactatttcc     3540

tctctgcaac ccgaggatgt ggccacctat tactgtcagc gatataatcg tgcaccttac     3600

acattcggcc aaggtaccaa agtagaaatc aagcgaactg tggctgcacc atctgtcttc     3660

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     3720

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg     3780

ggcaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     3840

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc     3900

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttgacaa     3960

ttgctgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga     4020

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt     4080

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg     4140

attgggaaga caatagcagg catgctgggg atgcggtggg ctctatg                   4187


<210>  136
<211>  4802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #19 Native adalimumab H-IRES-L (including ITRs)

<400>  136
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg tacaggatgc aactcctgtc     1920

ttgcattgca ctaagtcttg cacttgtcac aaactcggac atccagatga cccaaagccc     1980

ctcctctctg tcagccagtg tgggcgatcg ggtcacaatt acttgcagag cttcgcaggg     2040

aataaggaac tacctcgcat ggtatcagca aaagcctggg aaagcgccaa agttgcttat     2100

ctacgccgcc agcacgctgc agtccggtgt tccgtctcgc ttctctggca gtggaagcgg     2160

gaccgacttt acattaacta tttcctctct gcaacccgag gatgtggcca cctattactg     2220

tcagcgatat aatcgtgcac cttacacatt cggccaaggt accaaagtag aaatcaagcg     2280

aactgtggct gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg     2340

aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg     2400

gaaggtggat aacgccctcc aatcgggcaa ctcccaggag agtgtcacag agcaggacag     2460

caaggacagc acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa     2520

acacaaagtc tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag     2580

cttcaacagg ggagagtgtt gagcccctct ccctcccccc cccctaacgt tactggccga     2640

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg     2700

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg     2760

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt     2820

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac     2880

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca     2940

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg     3000

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg     3060

ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag gttaaaaaaa     3120

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat     3180

ggccacaatg cacagctcag cactgctctg ttgcctggtc ctcctgactg gggtgagggc     3240

cgaggtgcag ctggtcgaaa gcggcggagg gctcgttcaa cccggtcggt ccttgagact     3300

ttcttgcgcc gcttctggct tcacctttga cgattacgca atgcactggg tgaggcaggc     3360

gcctggaaag gggctggagt gggtatcagc catcacatgg aactcgggcc atattgacta     3420

tgctgatagc gtggaaggtc gcttcactat atcccgagac aatgccaaaa actctttata     3480

cctgcagatg aattcactac gtgcagagga tacggccgtc tattactgtg ctaaggtgtc     3540

atatctcagc accgcatcct ctctggacta ctggggacaa gggacattgg ttactgtgag     3600

ctccgcctcc accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc     3660

tgggggcaca gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt     3720

gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc     3780

ctcaggactc tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca     3840

gacctacatc tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga     3900

gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg     3960

gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac     4020

ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa     4080

ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta     4140

caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg     4200

caaggagtac aagtgcaagg tctccaacaa agccctccca gcccctatcg agaaaacaat     4260

ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga     4320

tgagctgacc aagaaccaag tcagcctgac ctgcctggtc aaaggcttct atcccagcga     4380

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc     4440

cgtgctggac tccgacggct ccttcttcct ctactccaag ctcaccgtgg acaagagcag     4500

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta     4560

cacgcagaag agcctctccc tgtctccggg caaatgacaa ttgaataaaa gatctttatt     4620

ttcattagat ctgtgtgttg gttttttgtg tggagctcga gaggaacccc tagtgatgga     4680

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4740

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcagatc     4800

tg                                                                    4802


<210>  137
<211>  4504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #19 Native adalimumab H-IRES-L Antibody expression cassette 
       (w/o ITRs)

<400>  137
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      540

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      600

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      660

agtcgctgcg cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      720

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      780

gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc tgcgtgaaag      840

ccttgagggg ctccgggagg gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt      900

gtgtgtgtgc gtggggagcg ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg      960

cgggcgcggc gcggggcttt gtgcgctccg cagtgtgcgc gagaggagcg cggccggggg     1020

cggtgccacg cggtgcgggg ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg     1080

cgtggggggg gtgagcaggg ggtgtgggcg cggcggtcgg gctgtaaccc ccccctgcac     1140

ccccctcccc gagttgctga gcacggcccg gcttcgggtg cggggctccg tgcggggcgt     1200

ggcgcggggc tcgccgtgcc gggcgggggg tggcggcggg tgggggtgcc gggcggggcg     1260

gggccgcctc gggccgggga gggctcgggg gaggggcgcg gcggcccccg gagcgccggc     1320

ggctgtcgag gcgcggcgag ccgcagccat tgccttttat ggtaatcgtg cgagagggcg     1380

cagggacttc ctttgtccca aatctgtgcg gagccgaaat ctgggaggcg ccgccgcacc     1440

ccctctagcg ggcgcggggc gaagcggtgc ggcgccggca ggaaggaaat gggcggggag     1500

ggccttcgtg cgtcgccgcg ccgccgtccc cttctccctc tccagcctcg gggctgtccg     1560

cggggggacg gctgccttcg ggggggacgg ggcagggcgg ggttcggctt ctggcgtgtg     1620

accggcggtc tagactctgc taaccatgtt catgccttct tctctttcct acagctcctg     1680

ggcaacgtgc tggttgttgt gctgtctcat cattttggca aagaattcaa gcttccagct     1740

agcgccacca tgtacaggat gcaactcctg tcttgcattg cactaagtct tgcacttgtc     1800

acaaactcgg acatccagat gacccaaagc ccctcctctc tgtcagccag tgtgggcgat     1860

cgggtcacaa ttacttgcag agcttcgcag ggaataagga actacctcgc atggtatcag     1920

caaaagcctg ggaaagcgcc aaagttgctt atctacgccg ccagcacgct gcagtccggt     1980

gttccgtctc gcttctctgg cagtggaagc gggaccgact ttacattaac tatttcctct     2040

ctgcaacccg aggatgtggc cacctattac tgtcagcgat ataatcgtgc accttacaca     2100

ttcggccaag gtaccaaagt agaaatcaag cgaactgtgg ctgcaccatc tgtcttcatc     2160

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat     2220

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggc     2280

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc     2340

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc     2400

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttgagcccct     2460

ctccctcccc cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt     2520

ttgtctatat gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac     2580

ctggccctgt cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc     2640

aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa     2700

cgtctgtagc gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg     2760

gccaaaagcc acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg     2820

tgagttggat agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc     2880

tgaaggatgc ccagaaggta ccccattgta tgggatctga tctggggcct cggtacacat     2940

gctttacatg tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg     3000

tggttttcct ttgaaaaaca cgatgataat atggccacaa tgcacagctc agcactgctc     3060

tgttgcctgg tcctcctgac tggggtgagg gccgaggtgc agctggtcga aagcggcgga     3120

gggctcgttc aacccggtcg gtccttgaga ctttcttgcg ccgcttctgg cttcaccttt     3180

gacgattacg caatgcactg ggtgaggcag gcgcctggaa aggggctgga gtgggtatca     3240

gccatcacat ggaactcggg ccatattgac tatgctgata gcgtggaagg tcgcttcact     3300

atatcccgag acaatgccaa aaactcttta tacctgcaga tgaattcact acgtgcagag     3360

gatacggccg tctattactg tgctaaggtg tcatatctca gcaccgcatc ctctctggac     3420

tactggggac aagggacatt ggttactgtg agctccgcct ccaccaaggg cccatcggtc     3480

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg     3540

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc     3600

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg     3660

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag     3720

cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca     3780

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     3840

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     3900

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     3960

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     4020

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     4080

aaagccctcc cagcccctat cgagaaaaca atctccaaag ccaaagggca gccccgagaa     4140

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca agtcagcctg     4200

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     4260

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     4320

ctctactcca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     4380

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     4440

ggcaaatgac aattgaataa aagatcttta ttttcattag atctgtgtgt tggttttttg     4500

tgtg                                                                  4504


<210>  138
<211>  4294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #20 Native adalimumab dual promoter (including ITRs)

<400>  138
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gaaggaactg aaaaaccaga      780

aagttaactg gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg      840

tgcaaatcaa agaactgctc ctcagtggat gttgccttta cttctaggcc tgtacggaag      900

tgttacttct gctctaaaag ctgcggaatt gtagcccggt taattaagcc accatgtaca      960

ggatgcaact cctgtcttgc attgcactaa gtcttgcact tgtcacaaac tcggacatcc     1020

agatgaccca aagcccctcc tctctgtcag ccagtgtggg cgatcgggtc acaattactt     1080

gcagagcttc gcagggaata aggaactacc tcgcatggta tcagcaaaag cctgggaaag     1140

cgccaaagtt gcttatctac gccgccagca cgctgcagtc cggtgttccg tctcgcttct     1200

ctggcagtgg aagcgggacc gactttacat taactatttc ctctctgcaa cccgaggatg     1260

tggccaccta ttactgtcag cgatataatc gtgcacctta cacattcggc caaggtacca     1320

aagtagaaat caagcgaact gtggctgcac catctgtctt catcttcccg ccatctgatg     1380

agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc tatcccagag     1440

aggccaaagt acagtggaag gtggataacg ccctccaatc gggcaactcc caggagagtg     1500

tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg acgctgagca     1560

aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag ggcctgagct     1620

cgcccgtcac aaagagcttc aacaggggag agtgttgagc atgcctgtgc cttctagttg     1680

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     1740

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     1800

tattctgggg ggtggggtgg ggcaggacag caagggggag gattctcaga actaacatac     1860

gctctccatc aaaacaaaac gaaacaaaac aaactagcaa aataggctgt ccccagtgca     1920

agtgcaggtg ccagaacatt tctctatcga aggatctgcg atcgctccgg tgcccgtcag     1980

tgggcagagc gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga     2040

accggtgcct agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc     2100

cgcctttttc ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt     2160

ctttttcgca acgggtttgc cgccagaaca cagctgaagc ttcgaggggc tcgcatctct     2220

ccttcacgcg cccgccgccc tacctgaggc cgccatccac gccggttgag tcgcgttctg     2280

ccgcctcccg cctgtggtgc ctcctgaact gcgtccgccg tctaggtaag tttaaagctc     2340

aggtcgagac cgggcctttg tccggcgctc ccttggagcc tacctagact cagccggctc     2400

tccacgcttt gcctgaccct gcttgctcaa ctctacgtct ttgtttcgtt ttctgttctg     2460

cgccgttaca gatcgaagtt ggtcgtgagg cactgggcag gtaagtatca aggttacaag     2520

acaggtttaa ggagaccaat agaaactggg cttgtcgaga cagagaagac tcttgcgttt     2580

ctgataggca cctattggtc ttactgacat ccactttgcc tttctctcca caggtgtcca     2640

ctcccagttc aattacagct cttaaggcta gtttaaacca ccatgcacag ctcagcactg     2700

ctctgttgcc tggtcctcct gactggggtg agggccgagg tgcagctggt cgaaagcggc     2760

ggagggctcg ttcaacccgg tcggtccttg agactttctt gcgccgcttc tggcttcacc     2820

tttgacgatt acgcaatgca ctgggtgagg caggcgcctg gaaaggggct ggagtgggta     2880

tcagccatca catggaactc gggccatatt gactatgctg atagcgtgga aggtcgcttc     2940

actatatccc gagacaatgc caaaaactct ttatacctgc agatgaattc actacgtgca     3000

gaggatacgg ccgtctatta ctgtgctaag gtgtcatatc tcagcaccgc atcctctctg     3060

gactactggg gacaagggac attggttact gtgagctccg cctccaccaa gggcccatcg     3120

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     3180

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     3240

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     3300

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     3360

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3420

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     3480

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     3540

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     3600

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     3660

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     3720

aacaaagccc tcccagcccc tatcgagaaa acaatctcca aagccaaagg gcagccccga     3780

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaagtcagc     3840

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     3900

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     3960

ttcctctact ccaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     4020

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     4080

ccgggcaaat gacctaggaa taaaagatct ttattttcat tagatctgtg tgttggtttt     4140

ttgtgtgctc gagaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     4200

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     4260

tcagtgagcg agcgagcgcg cagctgcaga tctg                                 4294


<210>  139
<211>  3999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #20 Native adalimumab dual promoter Antibody expression 
       cassette (w/o ITRs)

<400>  139
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      600

agatcgcctg gagaaggaac tgaaaaacca gaaagttaac tggtaagttt agtctttttg      660

tcttttattt caggtcccgg atccggtggt ggtgcaaatc aaagaactgc tcctcagtgg      720

atgttgcctt tacttctagg cctgtacgga agtgttactt ctgctctaaa agctgcggaa      780

ttgtagcccg gttaattaag ccaccatgta caggatgcaa ctcctgtctt gcattgcact      840

aagtcttgca cttgtcacaa actcggacat ccagatgacc caaagcccct cctctctgtc      900

agccagtgtg ggcgatcggg tcacaattac ttgcagagct tcgcagggaa taaggaacta      960

cctcgcatgg tatcagcaaa agcctgggaa agcgccaaag ttgcttatct acgccgccag     1020

cacgctgcag tccggtgttc cgtctcgctt ctctggcagt ggaagcggga ccgactttac     1080

attaactatt tcctctctgc aacccgagga tgtggccacc tattactgtc agcgatataa     1140

tcgtgcacct tacacattcg gccaaggtac caaagtagaa atcaagcgaa ctgtggctgc     1200

accatctgtc ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt     1260

tgtgtgcctg ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa     1320

cgccctccaa tcgggcaact cccaggagag tgtcacagag caggacagca aggacagcac     1380

ctacagcctc agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta     1440

cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg     1500

agagtgttga gcatgcctgt gccttctagt tgccagccat ctgttgtttg cccctccccc     1560

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     1620

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     1680

agcaaggggg aggattctca gaactaacat acgctctcca tcaaaacaaa acgaaacaaa     1740

acaaactagc aaaataggct gtccccagtg caagtgcagg tgccagaaca tttctctatc     1800

gaaggatctg cgatcgctcc ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc     1860

ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg tggcgcgggg     1920

taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt gggggagaac     1980

cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt gccgccagaa     2040

cacagctgaa gcttcgaggg gctcgcatct ctccttcacg cgcccgccgc cctacctgag     2100

gccgccatcc acgccggttg agtcgcgttc tgccgcctcc cgcctgtggt gcctcctgaa     2160

ctgcgtccgc cgtctaggta agtttaaagc tcaggtcgag accgggcctt tgtccggcgc     2220

tcccttggag cctacctaga ctcagccggc tctccacgct ttgcctgacc ctgcttgctc     2280

aactctacgt ctttgtttcg ttttctgttc tgcgccgtta cagatcgaag ttggtcgtga     2340

ggcactgggc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     2400

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     2460

atccactttg cctttctctc cacaggtgtc cactcccagt tcaattacag ctcttaaggc     2520

tagtttaaac caccatgcac agctcagcac tgctctgttg cctggtcctc ctgactgggg     2580

tgagggccga ggtgcagctg gtcgaaagcg gcggagggct cgttcaaccc ggtcggtcct     2640

tgagactttc ttgcgccgct tctggcttca cctttgacga ttacgcaatg cactgggtga     2700

ggcaggcgcc tggaaagggg ctggagtggg tatcagccat cacatggaac tcgggccata     2760

ttgactatgc tgatagcgtg gaaggtcgct tcactatatc ccgagacaat gccaaaaact     2820

ctttatacct gcagatgaat tcactacgtg cagaggatac ggccgtctat tactgtgcta     2880

aggtgtcata tctcagcacc gcatcctctc tggactactg gggacaaggg acattggtta     2940

ctgtgagctc cgcctccacc aagggcccat cggtcttccc cctggcaccc tcctccaaga     3000

gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc cccgaaccgg     3060

tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc     3120

tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc agcagcttgg     3180

gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag gtggacaaga     3240

aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca gcacctgaac     3300

tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct     3360

cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca     3420

agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag ccgcgggagg     3480

agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac caggactggc     3540

tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cctatcgaga     3600

aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat     3660

cccgggatga gctgaccaag aaccaagtca gcctgacctg cctggtcaaa ggcttctatc     3720

ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca     3780

cgcctcccgt gctggactcc gacggctcct tcttcctcta ctccaagctc accgtggaca     3840

agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca     3900

accactacac gcagaagagc ctctccctgt ctccgggcaa atgacctagg aataaaagat     3960

ctttattttc attagatctg tgtgttggtt ttttgtgtg                            3999


<210>  140
<211>  4294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #21 (including ITRs)

<400>  140
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gaaggaactg aaaaaccaga      780

aagttaactg gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg      840

tgcaaatcaa agaactgctc ctcagtggat gttgccttta cttctaggcc tgtacggaag      900

tgttacttct gctctaaaag ctgcggaatt gtagcccggt taattaagcc accatgtaca      960

ggatgcaact cctgtcttgc attgcactaa gtcttgcact tgtcacaaac tcagacatcc     1020

agatgaccca aagcccctcc tctctgtcag ccagtgtggg ggatcgcgtc acaattactt     1080

gcagagcttc ccagggaata aggaactacc tcgcgtggta tcagcaaaag cctgggaaag     1140

cgccaaagtt gcttatctat gccgccagca ctctgcagtc aggtgttcct agtagattct     1200

ctggcagtgg aagcgggact gactttacat taactatttc ctctctgcaa cctgaggatg     1260

tggccaccta ttactgtcag cggtataatc gcgcacctta cacatttggc caaggtacca     1320

aagtagaaat caagcggact gtggctgcac catctgtctt catcttcccg ccatctgatg     1380

agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc tatcccagag     1440

aggccaaagt acagtggaag gtggataatg ccctccaaag tggcaactcc caggagagtg     1500

tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg accctgagca     1560

aagcagacta tgagaaacac aaagtctacg cgtgtgaagt cacccatcag ggcctgagct     1620

ccccagtcac aaagagcttc aacaggggag agtgttgagc atgcctgtgc cttctagttg     1680

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     1740

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     1800

tattctgggg ggtggggtgg ggcaggacag caagggggag gattctcaga actaacatac     1860

gctctccatc aaaacaaaac gaaacaaaac aaactagcaa aataggctgt ccccagtgca     1920

agtgcaggtg ccagaacatt tctctatcga aggatctgcg atcgctccgg tgcccgtcag     1980

tgggcagagc gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga     2040

accggtgcct agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc     2100

cgcctttttc ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt     2160

ctttttcgca acgggtttgc cgccagaaca cagctgaagc ttcgaggggc tcgcatctct     2220

ccttcacgcg cccgccgccc tacctgaggc cgccatccac gccggttgag tcgcgttctg     2280

ccgcctcccg cctgtggtgc ctcctgaact gcgtccgccg tctaggtaag tttaaagctc     2340

aggtcgagac cgggcctttg tccggcgctc ccttggagcc tacctagact cagccggctc     2400

tccacgcttt gcctgaccct gcttgctcaa ctctacgtct ttgtttcgtt ttctgttctg     2460

cgccgttaca gatcgaagtt ggtcgtgagg cactgggcag gtaagtatca aggttacaag     2520

acaggtttaa ggagaccaat agaaactggg cttgtcgaga cagagaagac tcttgcgttt     2580

ctgataggca cctattggtc ttactgacat ccactttgcc tttctctcca caggtgtcca     2640

ctcccagttc aattacagct cttaaggcta gtttaaacca ccatgcacag ctcagcactg     2700

ctctgttgcc tggtcctcct gactggggtg agggctgagg tgcagctggt tgaaagcggc     2760

ggagggcttg ttcaacctgg tagatccttg agactttctt gcgccgcttc tggcttcacc     2820

tttgatgatt atgcaatgca ctgggtgagg caggcgcctg gaaaggggct ggagtgggta     2880

tcagccatca catggaacag tggccatatt gactatgctg atagtgtgga aggtagattc     2940

actatatccc gcgacaatgc caaaaactct ttatacctgc agatgaattc actacgcgca     3000

gaggatactg cggtctatta ctgtgctaag gtgtcatatc tcagcaccgc atcctctctg     3060

gactactggg gacaagggac attggttact gtgagctccg cctccaccaa gggcccaagt     3120

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     3180

ctggtcaagg actacttccc tgaacctgtg acagtgtctt ggaactcagg cgccctgacc     3240

agcggagtgc acaccttccc agctgtccta cagtcctcag gactctactc cctcagcagt     3300

gtggtgactg tgccctccag cagcttgggc acccagacct acatctgcaa tgtgaatcac     3360

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga caaaactcac     3420

acatgcccac cttgcccagc acctgaactc ctggggggac catcagtctt cctcttcccc     3480

ccaaaaccca aggacaccct catgatctcc cgcacccctg aggtcacatg tgtggtggtg     3540

gatgtgagcc atgaagaccc tgaggtcaag ttcaactggt atgtggatgg tgtggaggtg     3600

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacatacag agtggtctct     3660

gtcctcactg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     3720

aacaaagccc tcccagcccc tattgagaaa acaatctcca aagccaaagg gcagcccagg     3780

gaaccacagg tgtacaccct gcccccatcc cgcgatgagc tgaccaagaa ccaggtctcc     3840

ctgacctgcc tggtcaaagg cttctatccc agtgacattg ctgtggagtg ggagagcaat     3900

gggcagcctg agaacaacta caagaccaca cctccagtgc tggactctga tggctccttc     3960

ttcctctact ccaagctcac tgtggacaag agcaggtggc agcaggggaa tgtcttctca     4020

tgcagtgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     4080

cctggcaaat gacctaggaa taaaagatct ttattttcat tagatctgtg tgttggtttt     4140

ttgtgtgctc gagaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     4200

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     4260

tcagtgagcg agcgagcgcg cagctgcaga tctg                                 4294


<210>  141
<211>  3999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #21 Antibody expression cassette (w/o ITRs)

<400>  141
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      600

agatcgcctg gagaaggaac tgaaaaacca gaaagttaac tggtaagttt agtctttttg      660

tcttttattt caggtcccgg atccggtggt ggtgcaaatc aaagaactgc tcctcagtgg      720

atgttgcctt tacttctagg cctgtacgga agtgttactt ctgctctaaa agctgcggaa      780

ttgtagcccg gttaattaag ccaccatgta caggatgcaa ctcctgtctt gcattgcact      840

aagtcttgca cttgtcacaa actcagacat ccagatgacc caaagcccct cctctctgtc      900

agccagtgtg ggggatcgcg tcacaattac ttgcagagct tcccagggaa taaggaacta      960

cctcgcgtgg tatcagcaaa agcctgggaa agcgccaaag ttgcttatct atgccgccag     1020

cactctgcag tcaggtgttc ctagtagatt ctctggcagt ggaagcggga ctgactttac     1080

attaactatt tcctctctgc aacctgagga tgtggccacc tattactgtc agcggtataa     1140

tcgcgcacct tacacatttg gccaaggtac caaagtagaa atcaagcgga ctgtggctgc     1200

accatctgtc ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt     1260

tgtgtgcctg ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa     1320

tgccctccaa agtggcaact cccaggagag tgtcacagag caggacagca aggacagcac     1380

ctacagcctc agcagcaccc tgaccctgag caaagcagac tatgagaaac acaaagtcta     1440

cgcgtgtgaa gtcacccatc agggcctgag ctccccagtc acaaagagct tcaacagggg     1500

agagtgttga gcatgcctgt gccttctagt tgccagccat ctgttgtttg cccctccccc     1560

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     1620

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     1680

agcaaggggg aggattctca gaactaacat acgctctcca tcaaaacaaa acgaaacaaa     1740

acaaactagc aaaataggct gtccccagtg caagtgcagg tgccagaaca tttctctatc     1800

gaaggatctg cgatcgctcc ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc     1860

ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg tggcgcgggg     1920

taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt gggggagaac     1980

cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt gccgccagaa     2040

cacagctgaa gcttcgaggg gctcgcatct ctccttcacg cgcccgccgc cctacctgag     2100

gccgccatcc acgccggttg agtcgcgttc tgccgcctcc cgcctgtggt gcctcctgaa     2160

ctgcgtccgc cgtctaggta agtttaaagc tcaggtcgag accgggcctt tgtccggcgc     2220

tcccttggag cctacctaga ctcagccggc tctccacgct ttgcctgacc ctgcttgctc     2280

aactctacgt ctttgtttcg ttttctgttc tgcgccgtta cagatcgaag ttggtcgtga     2340

ggcactgggc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     2400

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     2460

atccactttg cctttctctc cacaggtgtc cactcccagt tcaattacag ctcttaaggc     2520

tagtttaaac caccatgcac agctcagcac tgctctgttg cctggtcctc ctgactgggg     2580

tgagggctga ggtgcagctg gttgaaagcg gcggagggct tgttcaacct ggtagatcct     2640

tgagactttc ttgcgccgct tctggcttca cctttgatga ttatgcaatg cactgggtga     2700

ggcaggcgcc tggaaagggg ctggagtggg tatcagccat cacatggaac agtggccata     2760

ttgactatgc tgatagtgtg gaaggtagat tcactatatc ccgcgacaat gccaaaaact     2820

ctttatacct gcagatgaat tcactacgcg cagaggatac tgcggtctat tactgtgcta     2880

aggtgtcata tctcagcacc gcatcctctc tggactactg gggacaaggg acattggtta     2940

ctgtgagctc cgcctccacc aagggcccaa gtgtcttccc cctggcaccc tcctccaaga     3000

gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc cctgaacctg     3060

tgacagtgtc ttggaactca ggcgccctga ccagcggagt gcacaccttc ccagctgtcc     3120

tacagtcctc aggactctac tccctcagca gtgtggtgac tgtgccctcc agcagcttgg     3180

gcacccagac ctacatctgc aatgtgaatc acaagcccag caacaccaag gtggacaaga     3240

aagttgagcc caaatcttgt gacaaaactc acacatgccc accttgccca gcacctgaac     3300

tcctgggggg accatcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct     3360

cccgcacccc tgaggtcaca tgtgtggtgg tggatgtgag ccatgaagac cctgaggtca     3420

agttcaactg gtatgtggat ggtgtggagg tgcataatgc caagacaaag ccgcgggagg     3480

agcagtacaa cagcacatac agagtggtct ctgtcctcac tgtcctgcac caggactggc     3540

tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cctattgaga     3600

aaacaatctc caaagccaaa gggcagccca gggaaccaca ggtgtacacc ctgcccccat     3660

cccgcgatga gctgaccaag aaccaggtct ccctgacctg cctggtcaaa ggcttctatc     3720

ccagtgacat tgctgtggag tgggagagca atgggcagcc tgagaacaac tacaagacca     3780

cacctccagt gctggactct gatggctcct tcttcctcta ctccaagctc actgtggaca     3840

agagcaggtg gcagcagggg aatgtcttct catgcagtgt gatgcatgag gctctgcaca     3900

accactacac acagaagagc ctctccctgt ctcctggcaa atgacctagg aataaaagat     3960

ctttattttc attagatctg tgtgttggtt ttttgtgtg                            3999


<210>  142
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC #5

<400>  142
gaggtgcagc tggttgaaag tggaggaggg cttgttcaac ctggtagatc cttgagactt       60

tcttgtgctg cttctggctt cacctttgat gattatgcaa tgcactgggt gaggcaggca      120

cctggaaagg ggctggagtg ggtatcagcc atcacatgga acagtggcca tattgactat      180

gctgatagtg tggaaggtag attcactata tccagagaca atgccaaaaa ctctttatac      240

ctgcagatga attcactaag ggcagaggat actgctgtct attactgtgc taaggtatca      300

tatctcagca cagcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tctgcctcca ccaagggccc aagtgtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cagccctggg ctgcctggtc aaggactact tccctgaacc tgtgactgtg      480

tcttggaact caggtgccct gaccagtgga gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctgag ctctgtggtg acagtgccct ccagcagctt gggcacccag      600

acctacatct gcaatgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccttgcc cagcacctga actcctgggg      720

ggaccatcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctccagaacc      780

cctgaggtca catgtgtggt ggtggatgtg agccatgaag accctgaggt caagttcaac      840

tggtatgtgg atggtgtgga ggtgcataat gccaagacaa agcccaggga ggagcagtac      900

aacagcactt acagagtggt cagtgtcctc acagtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccattga gaaaaccatc     1020

tccaaagcca aagggcagcc cagggaacca caggtgtaca ccctgccccc atccagagat     1080

gagctgacca agaaccaggt ctccctgacc tgcctggtca aaggcttcta tccctctgac     1140

attgctgtgg agtgggagag caatgggcag ccagagaaca actacaagac cactcctcct     1200

gtgctggact ctgatggctc cttcttcctc tactccaagc tcacagtgga caagagcagg     1260

tggcagcagg ggaatgtctt ctcatgcagt gtgatgcatg aggctctgca caaccactac     1320

actcagaaga gcctctccct gtctcctggc aaa                                  1353


<210>  143
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH #5 Codon modified adalimumab VH

<400>  143
gaggtgcagc tggttgaaag tggaggaggg cttgttcaac ctggtagatc cttgagactt       60

tcttgtgctg cttctggctt cacctttgat gattatgcaa tgcactgggt gaggcaggca      120

cctggaaagg ggctggagtg ggtatcagcc atcacatgga acagtggcca tattgactat      180

gctgatagtg tggaaggtag attcactata tccagagaca atgccaaaaa ctctttatac      240

ctgcagatga attcactaag ggcagaggat actgctgtct attactgtgc taaggtatca      300

tatctcagca cagcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tct                                                                    363


<210>  144
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC #5

<400>  144
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tagagtcaca       60

attacttgca gagcttccca gggaataagg aactacttgg catggtatca gcaaaagcct      120

gggaaagctc caaagttgct tatctatgct gccagcactc tgcagtcagg tgttcctagt      180

agattctcag gcagtggaag tgggactgac tttacattaa ctatttcctc tctgcaacct      240

gaggatgtgg ccacctatta ctgtcagagg tataatagag caccttacac atttggccaa      300

ggtaccaaag tagaaatcaa gaggactgtg gctgcaccat ctgtcttcat cttcccccca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataatgccc tccaatcagg caactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc      540

ctgagcaaag cagactatga gaaacacaaa gtctatgcct gtgaagtcac ccatcagggc      600

ctgagctccc cagtcacaaa gagcttcaac aggggagagt gttga                      645


<210>  145
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL #5 Codon modified adalimumab

<400>  145
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtggggga tagagtcaca       60

attacttgca gagcttccca gggaataagg aactacttgg catggtatca gcaaaagcct      120

gggaaagctc caaagttgct tatctatgct gccagcactc tgcagtcagg tgttcctagt      180

agattctcag gcagtggaag tgggactgac tttacattaa ctatttcctc tctgcaacct      240

gaggatgtgg ccacctatta ctgtcagagg tataatagag caccttacac atttggccaa      300

ggtaccaaag tagaaatcaa g                                                321


<210>  146
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC #6

<400>  146
gaggtgcagc tggtcgaaag cggcggaggg ctcgttcaac ccggtcggtc cttgagactt       60

tcttgcgccg cttctggctt cacctttgac gattacgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtatcagcc atcacatgga actcgggcca tattgactat      180

gctgatagcg tggaaggtcg cttcactata tcccgagaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg tgcagaggat acggccgtct attactgtgc taaggtgtca      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccctatcga gaaaacaatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaagt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tactccaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  147
<211>  362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH #6 adalimumab

<400>  147
gaggtgcagc tggtcgaaag cggcggaggg ctcgttcaac ccggtcggtc cttgagactt       60

tcttgcgccg cttctggctt cacctttgac gattacgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtatcagcc atcacatgga actcgggcca tattgactat      180

gctgatagcg tggaaggtcg cttcactata tcccgagaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg tgcagaggat acggccgtct attactgtgc taaggtgtca      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tc                                                                     362


<210>  148
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC #6

<400>  148
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca       60

attacttgca gagcttcgca gggaataagg aactacctcg catggtatca gcaaaagcct      120

gggaaagcgc caaagttgct tatctacgcc gccagcacgc tgcagtccgg tgttccgtct      180

cgcttctctg gcagtggaag cgggaccgac tttacattaa ctatttcctc tctgcaaccc      240

gaggatgtgg ccacctatta ctgtcagcga tataatcgtg caccttacac attcggccaa      300

ggtaccaaag tagaaatcaa gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg caactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      645


<210>  149
<211>  313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL #6 adalimumab

<400>  149
gacatccaga tgacccaaag cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca       60

attacttgca gagcttcgca gggaataagg aactacctcg catggtatca gcaaaagcct      120

gggaaagcgc caaagttgct tatctacgcc gccagcacgc tgcagtccgg tgttccgtct      180

cgcttctctg gcagtggaag cgggaccgac tttacattaa ctatttcctc tctgcaaccc      240

gaggatgtgg ccacctatta ctgtcagcga tataatcgtg caccttacac attcggccaa      300

ggtaccaaag tag                                                         313


<210>  150
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC  #7

<400>  150
gaggtgcagc tggttgaaag cggcggaggg cttgttcaac ctggtagatc cttgagactt       60

tcttgcgccg cttctggctt cacctttgat gattatgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtatcagcc atcacatgga acagtggcca tattgactat      180

gctgatagtg tggaaggtag attcactata tcccgcgaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg cgcagaggat actgcggtct attactgtgc taaggtgtca      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tccgcctcca ccaagggccc aagtgtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccctgaacc tgtgacagtg      480

tcttggaact caggcgccct gaccagcgga gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagtgtggtg actgtgccct ccagcagctt gggcacccag      600

acctacatct gcaatgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccttgcc cagcacctga actcctgggg      720

ggaccatcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccgcacc      780

cctgaggtca catgtgtggt ggtggatgtg agccatgaag accctgaggt caagttcaac      840

tggtatgtgg atggtgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacat acagagtggt ctctgtcctc actgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccctattga gaaaacaatc     1020

tccaaagcca aagggcagcc cagggaacca caggtgtaca ccctgccccc atcccgcgat     1080

gagctgacca agaaccaggt ctccctgacc tgcctggtca aaggcttcta tcccagtgac     1140

attgctgtgg agtgggagag caatgggcag cctgagaaca actacaagac cacacctcca     1200

gtgctggact ctgatggctc cttcttcctc tactccaagc tcactgtgga caagagcagg     1260

tggcagcagg ggaatgtctt ctcatgcagt gtgatgcatg aggctctgca caaccactac     1320

acacagaaga gcctctccct gtctcctggc aaa                                  1353


<210>  151
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC  #8

<400>  151
gaggtgcagc tggtcgaaag cggcggaggg ctcgttcaac ccggtcggtc cttgagactt       60

tcttgcgccg cttctggctt cacctttgac gattacgcaa tgcactgggt gaggcaggcg      120

cctggaaagg ggctggagtg ggtatcagcc atcacatgga actcgggcca tattgactat      180

gctgatagcg tggaaggtcg cttcactata tcccgagaca atgccaaaaa ctctttatac      240

ctgcagatga attcactacg tgcagaggat acggccgtct attactgtgc taaggtgtca      300

tatctcagca ccgcatcctc tctggactac tggggacaag ggacattggt tactgtgagc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccctatcga gaaaacaatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaagt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tactccaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggc aaa                                  1353


<210>  152
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bGH PolyA

<400>  152
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180


<210>  153
<211>  4485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #23 (including ITRs)

<400>  153
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc tgaggtgcag ctggttgaaa gcggcggagg     1980

gcttgttcaa cctggtagat ccttgagact ttcttgcgcc gcttctggct tcacctttga     2040

tgattatgca atgcactggg tgaggcaggc gcctggaaag gggctggagt gggtatcagc     2100

catcacatgg aacagtggcc atattgacta tgctgatagt gtggaaggta gattcactat     2160

atcccgcgac aatgccaaaa actctttata cctgcagatg aattcactac gcgcagagga     2220

tactgcggtc tattactgtg ctaaggtgtc atatctcagc accgcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctccgcctcc accaagggcc caagtgtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     2400

caaggactac ttccctgaac ctgtgacagt gtcttggaac tcaggcgccc tgaccagcgg     2460

agtgcacacc ttcccagctg tcctacagtc ctcaggactc tactccctca gcagtgtggt     2520

gactgtgccc tccagcagct tgggcaccca gacctacatc tgcaatgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccttgc ccagcacctg aactcctggg gggaccatca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctcccgcac ccctgaggtc acatgtgtgg tggtggatgt     2760

gagccatgaa gaccctgagg tcaagttcaa ctggtatgtg gatggtgtgg aggtgcataa     2820

tgccaagaca aagccgcggg aggagcagta caacagcaca tacagagtgg tctctgtcct     2880

cactgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccctattg agaaaacaat ctccaaagcc aaagggcagc ccagggaacc     3000

acaggtgtac accctgcccc catcccgcga tgagctgacc aagaaccagg tctccctgac     3060

ctgcctggtc aaaggcttct atcccagtga cattgctgtg gagtgggaga gcaatgggca     3120

gcctgagaac aactacaaga ccacacctcc agtgctggac tctgatggct ccttcttcct     3180

ctactccaag ctcactgtgg acaagagcag gtggcagcag gggaatgtct tctcatgcag     3240

tgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc tgtctcctgg     3300

taaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactca gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca attacttgca gagcttccca     3540

gggaataagg aactacctcg cgtggtatca gcaaaagcct gggaaagcgc caaagttgct     3600

tatctatgcc gccagcactc tgcagtcagg tgttcctagt agattctctg gcagtggaag     3660

cgggactgac tttacattaa ctatttcctc tctgcaacct gaggatgtgg ccacctatta     3720

ctgtcagcgg tataatcgcg caccttacac atttggccaa ggtaccaaag tagaaatcaa     3780

gcggactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataatgccc tccaaagtgg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacc ctgagcaaag cagactatga     4020

gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc ctgagctccc cagtcacaaa     4080

gagcttcaac aggggagagt gttgacaatt gctgtgcctt ctagttgcca gccatctgtt     4140

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     4200

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     4260

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     4320

gcggtgggct ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc     4380

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4440

cccgggcggc ctcagtgagc gagcgagcgc gcagctgcag atctg                     4485


<210>  154
<211>  4190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #23 Antibody expression cassette (w/o ITRs)

<400>  154
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgcacag ctcagcactg ctctgttgcc tggtcctcct gactggggtg     1800

agggctgagg tgcagctggt tgaaagcggc ggagggcttg ttcaacctgg tagatccttg     1860

agactttctt gcgccgcttc tggcttcacc tttgatgatt atgcaatgca ctgggtgagg     1920

caggcgcctg gaaaggggct ggagtgggta tcagccatca catggaacag tggccatatt     1980

gactatgctg atagtgtgga aggtagattc actatatccc gcgacaatgc caaaaactct     2040

ttatacctgc agatgaattc actacgcgca gaggatactg cggtctatta ctgtgctaag     2100

gtgtcatatc tcagcaccgc atcctctctg gactactggg gacaagggac attggttact     2160

gtgagctccg cctccaccaa gggcccaagt gtcttccccc tggcaccctc ctccaagagc     2220

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc tgaacctgtg     2280

acagtgtctt ggaactcagg cgccctgacc agcggagtgc acaccttccc agctgtccta     2340

cagtcctcag gactctactc cctcagcagt gtggtgactg tgccctccag cagcttgggc     2400

acccagacct acatctgcaa tgtgaatcac aagcccagca acaccaaggt ggacaagaaa     2460

gttgagccca aatcttgtga caaaactcac acatgcccac cttgcccagc acctgaactc     2520

ctggggggac catcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     2580

cgcacccctg aggtcacatg tgtggtggtg gatgtgagcc atgaagaccc tgaggtcaag     2640

ttcaactggt atgtggatgg tgtggaggtg cataatgcca agacaaagcc gcgggaggag     2700

cagtacaaca gcacatacag agtggtctct gtcctcactg tcctgcacca ggactggctg     2760

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc tattgagaaa     2820

acaatctcca aagccaaagg gcagcccagg gaaccacagg tgtacaccct gcccccatcc     2880

cgcgatgagc tgaccaagaa ccaggtctcc ctgacctgcc tggtcaaagg cttctatccc     2940

agtgacattg ctgtggagtg ggagagcaat gggcagcctg agaacaacta caagaccaca     3000

cctccagtgc tggactctga tggctccttc ttcctctact ccaagctcac tgtggacaag     3060

agcaggtggc agcaggggaa tgtcttctca tgcagtgtga tgcatgaggc tctgcacaac     3120

cactacacac agaagagcct ctccctgtct cctggtaaaa gaaagagaag gagtggctca     3180

ggagcccctg tgaaacagac cctgaacttt gacctcttga agcttgctgg ggatgtggag     3240

tctaatcctg gtccaatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     3300

cttgtcacaa actcagacat ccagatgacc caaagcccct cctctctgtc agccagtgtg     3360

ggggatcgcg tcacaattac ttgcagagct tcccagggaa taaggaacta cctcgcgtgg     3420

tatcagcaaa agcctgggaa agcgccaaag ttgcttatct atgccgccag cactctgcag     3480

tcaggtgttc ctagtagatt ctctggcagt ggaagcggga ctgactttac attaactatt     3540

tcctctctgc aacctgagga tgtggccacc tattactgtc agcggtataa tcgcgcacct     3600

tacacatttg gccaaggtac caaagtagaa atcaagcgga ctgtggctgc accatctgtc     3660

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     3720

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa tgccctccaa     3780

agtggcaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     3840

agcagcaccc tgaccctgag caaagcagac tatgagaaac acaaagtcta cgcgtgtgaa     3900

gtcacccatc agggcctgag ctccccagtc acaaagagct tcaacagggg agagtgttga     3960

caattgctgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     4020

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     4080

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     4140

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg                4190


<210>  155
<211>  4737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #24 (including ITRs)

<400>  155
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc tgaggtgcag ctggttgaaa gcggcggagg     1980

gcttgttcaa cctggtagat ccttgagact ttcttgcgcc gcttctggct tcacctttga     2040

tgattatgca atgcactggg tgaggcaggc gcctggaaag gggctggagt gggtatcagc     2100

catcacatgg aacagtggcc atattgacta tgctgatagt gtggaaggta gattcactat     2160

atcccgcgac aatgccaaaa actctttata cctgcagatg aattcactac gcgcagagga     2220

tactgcggtc tattactgtg ctaaggtgtc atatctcagc accgcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctccgcctcc accaagggcc caagtgtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     2400

caaggactac ttccctgaac ctgtgacagt gtcttggaac tcaggcgccc tgaccagcgg     2460

agtgcacacc ttcccagctg tcctacagtc ctcaggactc tactccctca gcagtgtggt     2520

gactgtgccc tccagcagct tgggcaccca gacctacatc tgcaatgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccttgc ccagcacctg aactcctggg gggaccatca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctcccgcac ccctgaggtc acatgtgtgg tggtggatgt     2760

gagccatgaa gaccctgagg tcaagttcaa ctggtatgtg gatggtgtgg aggtgcataa     2820

tgccaagaca aagccgcggg aggagcagta caacagcaca tacagagtgg tctctgtcct     2880

cactgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccctattg agaaaacaat ctccaaagcc aaagggcagc ccagggaacc     3000

acaggtgtac accctgcccc catcccgcga tgagctgacc aagaaccagg tctccctgac     3060

ctgcctggtc aaaggcttct atcccagtga cattgctgtg gagtgggaga gcaatgggca     3120

gcctgagaac aactacaaga ccacacctcc agtgctggac tctgatggct ccttcttcct     3180

ctactccaag ctcactgtgg acaagagcag gtggcagcag gggaatgtct tctcatgcag     3240

tgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc tgtctcctgg     3300

taaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactca gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtggggga tcgcgtcaca attacttgca gagcttccca     3540

gggaataagg aactacctcg cgtggtatca gcaaaagcct gggaaagcgc caaagttgct     3600

tatctatgcc gccagcactc tgcagtcagg tgttcctagt agattctctg gcagtggaag     3660

cgggactgac tttacattaa ctatttcctc tctgcaacct gaggatgtgg ccacctatta     3720

ctgtcagcgg tataatcgcg caccttacac atttggccaa ggtaccaaag tagaaatcaa     3780

gcggactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataatgccc tccaaagtgg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacc ctgagcaaag cagactatga     4020

gaaacacaaa gtctacgcgt gtgaagtcac ccatcagggc ctgagctccc cagtcacaaa     4080

gagcttcaac aggggagagt gttgacaatt ggatctacgg gtggcatccc tgtgacccct     4140

ccccagtgcc tctcctggcc ctggaagttg ccactccagt gcccaccagc cttgtcctaa     4200

taaaattaag ttgcatcatt ttgtctgact aggtgtcctt ctataatatt atggggtgga     4260

ggggggtggt atggagcaag gggcaagttg ggaagacaac ctgtagggcc tgcggggtct     4320

attgggaacc aagctggagt gcagtggcac aatcttggct cactgcaatc tccgcctcct     4380

gggttcaagc gattctcctg cctcagcctc ccgagttgtt gggattccag gcatgcatga     4440

ccaggctcag ctaatttttg tttttttggt agagacgggg tttcaccata ttggccaggc     4500

tggtctccaa ctcctaatct caggtgatct acccaccttg gcctcccaaa ttgctgggat     4560

tacaggcgtg aaccactgct cccttccctg tccttctgga gctcgagagg aacccctagt     4620

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4680

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcag        4737


<210>  156
<211>  4592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #24 Antibody expression cassette (w/o ITRs)

<400>  156
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgcacag ctcagcactg ctctgttgcc tggtcctcct gactggggtg     1800

agggctgagg tgcagctggt tgaaagcggc ggagggcttg ttcaacctgg tagatccttg     1860

agactttctt gcgccgcttc tggcttcacc tttgatgatt atgcaatgca ctgggtgagg     1920

caggcgcctg gaaaggggct ggagtgggta tcagccatca catggaacag tggccatatt     1980

gactatgctg atagtgtgga aggtagattc actatatccc gcgacaatgc caaaaactct     2040

ttatacctgc agatgaattc actacgcgca gaggatactg cggtctatta ctgtgctaag     2100

gtgtcatatc tcagcaccgc atcctctctg gactactggg gacaagggac attggttact     2160

gtgagctccg cctccaccaa gggcccaagt gtcttccccc tggcaccctc ctccaagagc     2220

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc tgaacctgtg     2280

acagtgtctt ggaactcagg cgccctgacc agcggagtgc acaccttccc agctgtccta     2340

cagtcctcag gactctactc cctcagcagt gtggtgactg tgccctccag cagcttgggc     2400

acccagacct acatctgcaa tgtgaatcac aagcccagca acaccaaggt ggacaagaaa     2460

gttgagccca aatcttgtga caaaactcac acatgcccac cttgcccagc acctgaactc     2520

ctggggggac catcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     2580

cgcacccctg aggtcacatg tgtggtggtg gatgtgagcc atgaagaccc tgaggtcaag     2640

ttcaactggt atgtggatgg tgtggaggtg cataatgcca agacaaagcc gcgggaggag     2700

cagtacaaca gcacatacag agtggtctct gtcctcactg tcctgcacca ggactggctg     2760

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc tattgagaaa     2820

acaatctcca aagccaaagg gcagcccagg gaaccacagg tgtacaccct gcccccatcc     2880

cgcgatgagc tgaccaagaa ccaggtctcc ctgacctgcc tggtcaaagg cttctatccc     2940

agtgacattg ctgtggagtg ggagagcaat gggcagcctg agaacaacta caagaccaca     3000

cctccagtgc tggactctga tggctccttc ttcctctact ccaagctcac tgtggacaag     3060

agcaggtggc agcaggggaa tgtcttctca tgcagtgtga tgcatgaggc tctgcacaac     3120

cactacacac agaagagcct ctccctgtct cctggtaaaa gaaagagaag gagtggctca     3180

ggagcccctg tgaaacagac cctgaacttt gacctcttga agcttgctgg ggatgtggag     3240

tctaatcctg gtccaatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     3300

cttgtcacaa actcagacat ccagatgacc caaagcccct cctctctgtc agccagtgtg     3360

ggggatcgcg tcacaattac ttgcagagct tcccagggaa taaggaacta cctcgcgtgg     3420

tatcagcaaa agcctgggaa agcgccaaag ttgcttatct atgccgccag cactctgcag     3480

tcaggtgttc ctagtagatt ctctggcagt ggaagcggga ctgactttac attaactatt     3540

tcctctctgc aacctgagga tgtggccacc tattactgtc agcggtataa tcgcgcacct     3600

tacacatttg gccaaggtac caaagtagaa atcaagcgga ctgtggctgc accatctgtc     3660

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     3720

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa tgccctccaa     3780

agtggcaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     3840

agcagcaccc tgaccctgag caaagcagac tatgagaaac acaaagtcta cgcgtgtgaa     3900

gtcacccatc agggcctgag ctccccagtc acaaagagct tcaacagggg agagtgttga     3960

caattggatc tacgggtggc atccctgtga cccctcccca gtgcctctcc tggccctgga     4020

agttgccact ccagtgccca ccagccttgt cctaataaaa ttaagttgca tcattttgtc     4080

tgactaggtg tccttctata atattatggg gtggaggggg gtggtatgga gcaaggggca     4140

agttgggaag acaacctgta gggcctgcgg ggtctattgg gaaccaagct ggagtgcagt     4200

ggcacaatct tggctcactg caatctccgc ctcctgggtt caagcgattc tcctgcctca     4260

gcctcccgag ttgttgggat tccaggcatg catgaccagg ctcagctaat ttttgttttt     4320

ttggtagaga cggggtttca ccatattggc caggctggtc tccaactcct aatctcaggt     4380

gatctaccca ccttggcctc ccaaattgct gggattacag gcgtgaacca ctgctccctt     4440

ccctgtcctt ctggagctcg agaggaaccc ctagtgatgg agttggccac tccctctctg     4500

cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc     4560

cgggcggcct cagtgagcga gcgagcgcgc ag                                   4592


<210>  157
<211>  4595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #22

<400>  157
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tagtattaaa cgcgtgtcga cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggg tcgaggtgag      540

ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa ttttgtattt      600

atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg cgcgcgccag      660

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      720

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      780

ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg ctgccttcgc cccgtgcccc      840

gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact gaccgcgtta ctcccacagg      900

tgagcgggcg ggacggccct tctcctccgg gctgtaatta gcgcttggtt taatgacggc      960

tcgtttcttt tctgtggctg cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg     1020

gggggagcgg ctcggggggt gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct     1080

ccgcgctgcc cggcggctgt gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca     1140

gtgtgcgcga gaggagcgcg gccgggggcg gtgccacgcg gtgcgggggg ggctgcgagg     1200

ggaacaaagg ctgcgtgcgg ggtgtgtgcg tggggggggt gagcaggggg tgtgggcgcg     1260

gcggtcgggc tgtaaccccc ccctgcaccc ccctccccga gttgctgagc acggcccggc     1320

ttcgggtgcg gggctccgtg cggggcgtgg cgcggggctc gccgtgccgg gcggggggtg     1380

gcggcgggtg ggggtgccgg gcggggcggg gccgcctcgg gccggggagg gctcggggga     1440

ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc gcggcgagcc gcagccattg     1500

ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa tctgtgcgga     1560

gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcggggcga agcggtgcgg     1620

cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg tcgccgcgcc gccgtcccct     1680

tctccctctc cagcctcggg gctgtccgcg gggggacggc tgccttcggg ggggacgggg     1740

cagggcgggg ttcggcttct ggcgtgtgac cggcggtcta gactctgcta accatgttca     1800

tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc tgtctcatca     1860

ttttggcaaa gaattcaagc ttccagctag cgccaccatg cacagctcag cactgctctg     1920

ttgcctggtc ctcctgactg gggtgagggc cgaggtgcag ctggtcgaaa gcggcggagg     1980

gctcgttcaa cccggtcggt ccttgagact ttcttgcgcc gcttctggct tcacctttga     2040

cgattacgca atgcactggg tgaggcaggc gcctggaaag gggctggagt gggtatcagc     2100

catcacatgg aactcgggcc atattgacta tgctgatagc gtggaaggtc gcttcactat     2160

atcccgagac aatgccaaaa actctttata cctgcagatg aattcactac gtgcagagga     2220

tacggccgtc tattactgtg ctaaggtgtc atatctcagc accgcatcct ctctggacta     2280

ctggggacaa gggacattgg ttactgtgag ctccgcctcc accaagggcc catcggtctt     2340

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     2400

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     2460

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2520

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2580

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2640

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2700

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2760

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2820

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2880

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2940

agccctccca gcccctatcg agaaaacaat ctccaaagcc aaagggcagc cccgagaacc     3000

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccaag tcagcctgac     3060

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     3120

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     3180

ctactccaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     3240

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     3300

taaaagaaag agaaggagtg gctcaggagc ccctgtgaaa cagaccctga actttgacct     3360

cttgaagctt gctggggatg tggagtctaa tcctggtcca atgtacagga tgcaactcct     3420

gtcttgcatt gcactaagtc ttgcacttgt cacaaactcg gacatccaga tgacccaaag     3480

cccctcctct ctgtcagcca gtgtgggcga tcgggtcaca attacttgca gagcttcgca     3540

gggaataagg aactacctcg catggtatca gcaaaagcct gggaaagcgc caaagttgct     3600

tatctacgcc gccagcacgc tgcagtccgg tgttccgtct cgcttctctg gcagtggaag     3660

cgggaccgac tttacattaa ctatttcctc tctgcaaccc gaggatgtgg ccacctatta     3720

ctgtcagcga tataatcgtg caccttacac attcggccaa ggtaccaaag tagaaatcaa     3780

gcgaactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc     3840

tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca     3900

gtggaaggtg gataacgccc tccaatcggg caactcccag gagagtgtca cagagcagga     3960

cagcaaggac agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga     4020

gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa     4080

gagcttcaac aggggagagt gttgacctag gtccataaag taggaaacac tacactattc     4140

cataaagtag gaaacactac atcactccat aaagtaggaa acactacaag tctccataaa     4200

gtaggaaaca ctacacaatt gctgtgcctt ctagttgcca gccatctgtt gtttgcccct     4260

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     4320

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     4380

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     4440

ctatggagct cgagaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4500

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4560

ctcagtgagc gagcgagcgc gcagctgcag atctg                                4595


<210>  158
<211>  3960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EC #22 Antibody expression cassette (w/o ITRs)

<400>  158
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      720

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      780

tccgggctgt aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga      840

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      900

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      960

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagagga gcgcggccgg     1020

gggcggtgcc acgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     1080

gtgcgtgggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     1140

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg     1200

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc gggtgggggt gccgggcggg     1260

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     1320

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     1380

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     1440

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     1500

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     1560

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     1620

gtgaccggcg gtctagactc tgctaaccat gttcatgcct tcttctcttt cctacagctc     1680

ctgggcaacg tgctggttgt tgtgctgtct catcattttg gcaaagaatt caagcttcca     1740

gctagcgcca ccatgcacag ctcagcactg ctctgttgcc tggtcctcct gactggggtg     1800

agggccgagg tgcagctggt cgaaagcggc ggagggctcg ttcaacccgg tcggtccttg     1860

agactttctt gcgccgcttc tggcttcacc tttgacgatt acgcaatgca ctgggtgagg     1920

caggcgcctg gaaaggggct ggagtgggta tcagccatca catggaactc gggccatatt     1980

gactatgctg atagcgtgga aggtcgcttc actatatccc gagacaatgc caaaaactct     2040

ttatacctgc agatgaattc actacgtgca gaggatacgg ccgtctatta ctgtgctaag     2100

gtgtcatatc tcagcaccgc atcctctctg gactactggg gacaagggac attggttact     2160

gtgagctccg cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc     2220

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg     2280

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     2340

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     2400

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa     2460

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc     2520

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     2580

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     2640

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     2700

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     2760

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc tatcgagaaa     2820

acaatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     2880

cgggatgagc tgaccaagaa ccaagtcagc ctgacctgcc tggtcaaagg cttctatccc     2940

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     3000

cctcccgtgc tggactccga cggctccttc ttcctctact ccaagctcac cgtggacaag     3060

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     3120

cactacacgc agaagagcct ctccctgtct ccgggtaaaa gaaagagaag gagtggctca     3180

ggagcccctg tgaaacagac cctgaacttt gacctcttga agcttgctgg ggatgtggag     3240

tctaatcctg gtccaatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca     3300

cttgtcacaa actcggacat ccagatgacc caaagcccct cctctctgtc agccagtgtg     3360

ggcgatcggg tcacaattac ttgcagagct tcgcagggaa taaggaacta cctcgcatgg     3420

tatcagcaaa agcctgggaa agcgccaaag ttgcttatct acgccgccag cacgctgcag     3480

tccggtgttc cgtctcgctt ctctggcagt ggaagcggga ccgactttac attaactatt     3540

tcctctctgc aacccgagga tgtggccacc tattactgtc agcgatataa tcgtgcacct     3600

tacacattcg gccaaggtac caaagtagaa atcaagcgaa ctgtggctgc accatctgtc     3660

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     3720

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa     3780

tcgggcaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     3840

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa     3900

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttga     3960


<210>  159
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain CDR3 Codon modified adalimumab #5

<400>  159
gtatcatatc tcagcacagc atcctctctg gactac                                 36


<210>  160
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR2 Codon modified adalimumab #5

<400>  160
gctgccagca ctctgcagtc a                                                 21


<210>  161
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain  CDR 2 Adalimumab #6

<400>  161
gccgccagca cgctgcagtc c                                                 21


