                         SEQUENCE LISTING

<110>  Immunis, Inc.
 
<120>  METHODS OF PREPARATION OF SECRETOMES, AND USES THEREOF

<130>  IMBIO.002.WO

<140>  PCT/US2022/013834
<141>  2022-01-26

<150>  63/142,456
<151>  2021-01-27

<150>  63/169,203
<151>  2021-03-31

<150>  63/177,346
<151>  2021-04-20

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform FST344 precursor [Homo sapiens]

<400>  1

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly 
    210                 215                 220                 


Lys Lys Cys Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu 
225                 230                 235                 240 


Cys Asp Glu Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala 
                245                 250                 255     


Ser Asp Asn Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala 
            260                 265                 270         


Cys Ser Ser Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
        275                 280                 285             


Ser Ile Ser Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp 
    290                 295                 300                 


Tyr Ser Phe Pro Ile Ser Ser Ile Leu Glu Trp 
305                 310                 315 


<210>  2
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform FST317 precursor [Homo sapiens]

<400>  2

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly 
    210                 215                 220                 


Lys Lys Cys Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu 
225                 230                 235                 240 


Cys Asp Glu Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala 
                245                 250                 255     


Ser Asp Asn Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala 
            260                 265                 270         


Cys Ser Ser Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
        275                 280                 285             


<210>  3
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform X1 [Homo sapiens]

<400>  3

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Ser Arg Tyr Ser Gly Leu Arg Lys Glu Lys Glu Lys Thr 
    210                 215                 220                 


Glu Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
225                 230                 235                 240 


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
                245                 250                 255     


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
            260                 265                 270         


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
        275                 280                 285             


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Ile Ser 
    290                 295                 300                 


Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr Ser Phe 
305                 310                 315                 320 


Pro Ile Ser Ser Ile Leu Glu Trp 
                325             


<210>  4
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform X2 [Homo sapiens]

<400>  4

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Ser Arg Tyr Ser Gly Leu Arg Lys Glu Lys Glu Lys Thr 
    210                 215                 220                 


Glu Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
225                 230                 235                 240 


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
                245                 250                 255     


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
            260                 265                 270         


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
        275                 280                 285             


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Ile Ser 
    290                 295                 300                 


Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr Ser Phe 
305                 310                 315                 320 


Pro Ile Ser Ser Ile Leu Glu Trp 
                325             


<210>  5
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform X3 [Homo sapiens]

<400>  5

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Thr Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys 
    210                 215                 220                 


Lys Cys Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys 
225                 230                 235                 240 


Asp Glu Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser 
                245                 250                 255     


Asp Asn Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys 
            260                 265                 270         


Ser Ser Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser 
        275                 280                 285             


Ile Ser Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr 
    290                 295                 300                 


Ser Phe Pro Ile Ser Ser Ile Leu Glu Trp 
305                 310                 


<210>  6
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform X4 [Homo sapiens]

<400>  6

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Thr Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys 
    210                 215                 220                 


Lys Cys Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys 
225                 230                 235                 240 


Asp Glu Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser 
                245                 250                 255     


Asp Asn Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys 
            260                 265                 270         


Ser Ser Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser 
        275                 280                 285             


Ile Ser Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr 
    290                 295                 300                 


Ser Phe Pro Ile Ser Ser Ile Leu Glu Trp 
305                 310                 


<210>  7
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform X5 [Homo sapiens]

<400>  7

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Ser Arg Tyr Ser Gly Leu Arg Lys Glu Lys Glu Lys Thr 
    210                 215                 220                 


Glu Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
225                 230                 235                 240 


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
                245                 250                 255     


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
            260                 265                 270         


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
        275                 280                 285             


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Pro Leu 
    290                 295                 300                 


Tyr Ser Pro Ile 
305             


<210>  8
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform X6 [Homo sapiens]

<400>  8

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Ser Arg Tyr Ser Gly Leu Arg Lys Glu Lys Glu Lys Thr 
    210                 215                 220                 


Glu Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
225                 230                 235                 240 


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
                245                 250                 255     


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
            260                 265                 270         


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
        275                 280                 285             


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
    290                 295                 300     


<210>  9
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform X7 [Homo sapiens]

<400>  9

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Thr Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys 
    210                 215                 220                 


Lys Cys Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys 
225                 230                 235                 240 


Asp Glu Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser 
                245                 250                 255     


Asp Asn Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys 
            260                 265                 270         


Ser Ser Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
        275                 280                 285         


<210>  10
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin isoform X8 [Homo sapiens]

<400>  10

Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu Thr 
1               5                   10                  15      


Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn Lys 
            20                  25                  30          


Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr 
        35                  40                  45              


Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu 
    50                  55                  60                  


Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val 
65                  70                  75                  80  


Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro 
                85                  90                  95      


Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val 
            100                 105                 110         


Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu 
        115                 120                 125             


Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys 
    130                 135                 140                 


Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys 
145                 150                 155                 160 


Cys Ile Ser Arg Tyr Ser Gly Leu Arg Lys Glu Lys Glu Lys Thr Glu 
                165                 170                 175     


Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys Leu 
            180                 185                 190         


Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu Leu 
        195                 200                 205             


Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn Ala 
    210                 215                 220                 


Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser Gly 
225                 230                 235                 240 


Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Ile Ser Glu 
                245                 250                 255     


Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr Ser Phe Pro 
            260                 265                 270         


Ile Ser Ser Ile Leu Glu Trp 
        275                 


<210>  11
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin, isoform CRA_b [Homo sapiens]

<400>  11

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Val Tyr Gln 
            100                 105                 110     


<210>  12
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FST [Homo sapiens]

<400>  12

Gly Asn Cys Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu 
1               5                   10                  15      


Tyr Lys Thr Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu 
            20                  25                  30          


Ser Thr Ser Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys 
        35                  40                  45              


Trp Met Ile Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu 
    50                  55                  60                  


Thr Cys Glu Asn Val Asp Cys Gly Pro Glu Lys Lys Cys Arg Met Asn 
65                  70                  75                  80  


Lys Lys Asn Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile 
                85                  90                  95      


Thr Trp Lys Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Cys Asn 
            100                 105                 110         


Glu Cys Ala Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu 
        115                 120                 125             


Val Gln Tyr Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys 
    130                 135                 140                 


Pro Gly Ser Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys 
145                 150                 155                 160 


Val Thr Cys Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr 
                165                 170                 175     


Leu Cys Gly Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg 
            180                 185                 190         


Lys Ala Thr Cys Leu Leu Gly Arg Ser Ile Gly Leu Val Tyr Glu Gly 
        195                 200                 205             


Lys Cys Ile Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly 
    210                 215                 220                 


Lys Lys Cys Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu 
225                 230                 235                 240 


Cys Asp Glu Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala 
                245                 250                 255     


Ser Asp Asn Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala 
            260                 265                 270         


Cys Ser Ser Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
        275                 280                 285             


<210>  13
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin like 1 [ Homo sapiens]

<400>  13

Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala Asn Val Phe Cys 
1               5                   10                  15      


Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly Glu Pro Thr Cys 
            20                  25                  30          


Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro Val Cys Gly Ser 
        35                  40                  45              


Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His Arg Asp Ala Cys 
    50                  55                  60                  


Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly His Cys Lys Glu 
65                  70                  75                  80  


Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val Cys Tyr Gln Ser 
                85                  90                  95      


Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp Leu Glu Ala Glu 
            100                 105                 110         


Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn Tyr Ser Glu Ile 
        115                 120                 125             


Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp Ser Arg Leu Asp 
    130                 135                 140                 


Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu Thr Ala Ile Asn 
145                 150                 155                 160 


Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu Leu Arg Gly Leu 
                165                 170                 175     


Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn Ala Asp Trp Lys 
            180                 185                 190         


Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro Ser Phe Asn Pro 
        195                 200                 205             


Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr Ala Asp Gly Ala 
    210                 215                 220                 


Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala Cys Gly Asn Trp 
225                 230                 235                 240 


Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln Lys Gly Ala Gln 
                245                 250                 255     


Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln Glu Leu Gln Lys 
            260                 265                 270         


His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser Thr Lys Glu Ile 
        275                 280                 285             


<210>  14
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin-N-terminal domains

<400>  14

Thr Cys Glu Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn 
1               5                   10                  15      


Lys Lys Asn Lys Pro Arg Cys Val 
            20                  


<210>  15
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin-N-terminal domains

<400>  15

Thr Cys Glu Asn Val Asp Cys Gly Pro Glu Lys Lys Cys Arg Met Asn 
1               5                   10                  15      


Lys Lys Asn Lys Pro Arg Cys Val 
            20                  


<210>  16
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Follistatin-N-terminal domains

<400>  16

Cys Ala Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu 
1               5                   10                  15      


Lys Gly Glu Pro Thr Cys Leu 
            20              


<210>  17
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform 1

<400>  17

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Ala Asp Ser Ala Glu Asp Val Arg Lys Val 
        115                 120                 125             


Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val 
    130                 135                 140                 


His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly 
145                 150                 155                 160 


Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu 
                165                 170                 175     


Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val 
            180                 185                 190         


Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys 
        195                 200                 205             


Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala 
    210                 215                 220                 


Glu Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser 
225                 230                 235                 240 


Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val 
                245                 250                 255     


Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro 
            260                 265                 270         


Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro Pro 
        275                 280                 285             


Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe Met 
    290                 295                 300                 


Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro Arg 
305                 310                 315                 320 


Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly Pro 
                325                 330                 335     


Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
            340                 345                 350 


<210>  18
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform 2

<400>  18

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys 
        115                 120                 125             


Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His 
    130                 135                 140                 


Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser 
145                 150                 155                 160 


Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro 
                165                 170                 175     


Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala 
            180                 185                 190         


Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Gln 
        195                 200                 205             


Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala Glu 
    210                 215                 220                 


Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser Gln 
225                 230                 235                 240 


Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val Asp 
                245                 250                 255     


Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro Pro 
            260                 265                 270         


Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro Pro Gly 
        275                 280                 285             


His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe Met Gly 
    290                 295                 300                 


Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro Arg Lys 
305                 310                 315                 320 


Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly Pro Val 
                325                 330                 335     


Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
            340                 345                 


<210>  19
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform 3

<400>  19

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile Asp 
    50                  55                  60                  


Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala Arg 
65                  70                  75                  80  


Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys Asp 
                85                  90                  95      


Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala Lys 
            100                 105                 110         


Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys Gln 
        115                 120                 125             


Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His Ala 
    130                 135                 140                 


Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser Asn 
145                 150                 155                 160 


Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro Pro 
                165                 170                 175     


Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala Lys 
            180                 185                 190         


Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Gln Tyr 
        195                 200                 205             


Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala Glu Val 
    210                 215                 220                 


Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser Gln Pro 
225                 230                 235                 240 


Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val Asp Pro 
                245                 250                 255     


Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro Pro Ala 
            260                 265                 270         


Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro Pro Gly His 
        275                 280                 285             


Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe Met Gly Val 
    290                 295                 300                 


Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro Arg Lys Thr 
305                 310                 315                 320 


Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly Pro Val Val 
                325                 330                 335     


Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
            340                 345             


<210>  20
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A isoform 4

<400>  20

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys 
        115                 120                 125             


Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His 
    130                 135                 140                 


Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser 
145                 150                 155                 160 


Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro 
                165                 170                 175     


Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala 
            180                 185                 190         


Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Pro 
        195                 200                 205             


Val Ser Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr 
    210                 215                 220                 


Pro Val Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro 
225                 230                 235                 240 


Gly Leu Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala 
                245                 250                 255     


Ala Pro Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His 
            260                 265                 270         


Thr Phe Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser 
        275                 280                 285             


His Pro Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala 
    290                 295                 300                 


Ala Gly Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys 
305                 310                 315                 320 


Val 
    


<210>  21
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A protein isoforms

<400>  21

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Ala Asp Ser Ala Glu Asp Val Arg Lys Val 
        115                 120                 125             


Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val 
    130                 135                 140                 


His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly 
145                 150                 155                 160 


Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu 
                165                 170                 175     


Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val 
            180                 185                 190         


Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys 
        195                 200                 205             


Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala 
    210                 215                 220                 


Glu Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser 
225                 230                 235                 240 


Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val 
                245                 250                 255     


Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro 
            260                 265                 270         


Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu 
        275                 280             


<210>  22
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A protein isoforms linker

<400>  22

Leu Ala Ala Pro Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu 
1               5                   10                  15      


Arg His Thr Phe Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu 
            20                  25                  30          


Val Ser His Pro Arg Lys Thr Arg 
        35                  40  


<210>  23
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A protein isoforms Chain B

<400>  23

Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly Pro Val Val Pro 
1               5                   10                  15      


Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
            20                  25          


<210>  24
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A protein isoforms Chain A

<400>  24

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys 
        115                 120                 125             


Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His 
    130                 135                 140                 


Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser 
145                 150                 155                 160 


Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro 
                165                 170                 175     


Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala 
            180                 185                 190         


Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Gln 
        195                 200                 205             


Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala Glu 
    210                 215                 220                 


Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser Gln 
225                 230                 235                 240 


Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val Asp 
                245                 250                 255     


Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro Pro 
            260                 265                 270         


Ala Gly Ser Pro Pro Asp Ser His Val Leu 
        275                 280         


<210>  25
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A protein isoforms Chain A

<400>  25

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile Asp 
    50                  55                  60                  


Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala Arg 
65                  70                  75                  80  


Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys Asp 
                85                  90                  95      


Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala Lys 
            100                 105                 110         


Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys Gln 
        115                 120                 125             


Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His Ala 
    130                 135                 140                 


Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser Asn 
145                 150                 155                 160 


Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro Pro 
                165                 170                 175     


Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala Lys 
            180                 185                 190         


Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Gln Tyr 
        195                 200                 205             


Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly Ala Glu Val 
    210                 215                 220                 


Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser Ser Gln Pro 
225                 230                 235                 240 


Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val Val Asp Pro 
                245                 250                 255     


Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu Pro Pro Ala 
            260                 265                 270         


Gly Ser Pro Pro Asp Ser His Val Leu 
        275                 280     


<210>  26
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fetuin A protein isoforms Chain A

<400>  26

Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys Asp Asp 
1               5                   10                  15      


Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile Asn Gln 
            20                  25                  30          


Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp Glu Val 
        35                  40                  45              


Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile Glu Ile 
    50                  55                  60                  


Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro Val Ala 
65                  70                  75                  80  


Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly Asp Cys 
                85                  90                  95      


Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr Ala 
            100                 105                 110         


Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys Val Cys 
        115                 120                 125             


Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val Val His 
    130                 135                 140                 


Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser 
145                 150                 155                 160 


Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro Leu Pro 
                165                 170                 175     


Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys Val Ala 
            180                 185                 190         


Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu Lys Pro 
        195                 200                 205             


Val Ser Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr 
    210                 215                 220                 


Pro Val Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro 
225                 230                 235                 240 


Gly Leu Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu 
                245                 250                 


<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-beta binding domain

<400>  27

Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val Tyr 
1               5                   10                  15      


Ala Lys Cys 
            


