                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  METHODS AND COMPOSITIONS FOR TARGETING SV2 PROTEINS FOR IMMUNE 
       REGULATION

<130>  UCLA.P0131WO/1001196030

<140>  
<141>  2022-01-25

<150>  63/141,778
<151>  2021-01-26

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  17850
<212>  DNA
<213>  SARS-CoV-2

<400>  1
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct       60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact      120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc      180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt      240

cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac      300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg      360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg      420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa      480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact      540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg      600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag aacggtaata aaggagctgg      660

tggccatagt tacggcgccg atctaaagtc atttgactta ggcgacgagc ttggcactga      720

tccttatgaa gattttcaag aaaactggaa cactaaacat agcagtggtg ttacccgtga      780

actcatgcgt gagcttaacg gaggggcata cactcgctat gtcgataaca acttctgtgg      840

ccctgatggc taccctcttg agtgcattaa agaccttcta gcacgtgctg gtaaagcttc      900

atgcactttg tccgaacaac tggactttat tgacactaag aggggtgtat actgctgccg      960

tgaacatgag catgaaattg cttggtacac ggaacgttct gaaaagagct atgaattgca     1020

gacacctttt gaaattaaat tggcaaagaa atttgacacc ttcaatgggg aatgtccaaa     1080

ttttgtattt cccttaaatt ccataatcaa gactattcaa ccaagggttg aaaagaaaaa     1140

gcttgatggc tttatgggta gaattcgatc tgtctatcca gttgcgtcac caaatgaatg     1200

caaccaaatg tgcctttcaa ctctcatgaa gtgtgatcat tgtggtgaaa cttcatggca     1260

gacgggcgat tttgttaaag ccacttgcga attttgtggc actgagaatt tgactaaaga     1320

aggtgccact acttgtggtt acttacccca aaatgctgtt gttaaaattt attgtccagc     1380

atgtcacaat tcagaagtag gacctgagca tagtcttgcc gaataccata atgaatctgg     1440

cttgaaaacc attcttcgta agggtggtcg cactattgcc tttggaggct gtgtgttctc     1500

ttatgttggt tgccataaca agtgtgccta ttgggttcca cgtgctagcg ctaacatagg     1560

ttgtaaccat acaggtgttg ttggagaagg ttccgaaggt cttaatgaca accttcttga     1620

aatactccaa aaagagaaag tcaacatcaa tattgttggt gactttaaac ttaatgaaga     1680

gatcgccatt attttggcat ctttttctgc ttccacaagt gcttttgtgg aaactgtgaa     1740

aggtttggat tataaagcat tcaaacaaat tgttgaatcc tgtggtaatt ttaaagttac     1800

aaaaggaaaa gctaaaaaag gtgcctggaa tattggtgaa cagaaatcaa tactgagtcc     1860

tctttatgca tttgcatcag aggctgctcg tgttgtacga tcaattttct cccgcactct     1920

tgaaactgct caaaattctg tgcgtgtttt acagaaggcc gctataacaa tactagatgg     1980

aatttcacag tattcactga gactcattga tgctatgatg ttcacatctg atttggctac     2040

taacaatcta gttgtaatgg cctacattac aggtggtgtt gttcagttga cttcgcagtg     2100

gctaactaac atctttggca ctgtttatga aaaactcaaa cccgtccttg attggcttga     2160

agagaagttt aaggaaggtg tagagtttct tagagacggt tgggaaattg ttaaatttat     2220

ctcaacctgt gcttgtgaaa ttgtcggtgg acaaattgtc acctgtgcaa aggaaattaa     2280

ggagagtgtt cagacattct ttaagcttgt aaataaattt ttggctttgt gtgctgactc     2340

tatcattatt ggtggagcta aacttaaagc cttgaattta ggtgaaacat ttgtcacgca     2400

ctcaaaggga ttgtacagaa agtgtgttaa atccagagaa gaaactggcc tactcatgcc     2460

tctaaaagcc ccaaaagaaa ttatcttctt agagggagaa acacttccca cagaagtgtt     2520

aacagaggaa gttgtcttga aaactggtga tttacaacca ttagaacaac ctactagtga     2580

agctgttgaa gctccattgg ttggtacacc agtttgtatt aacgggctta tgttgctcga     2640

aatcaaagac acagaaaagt actgtgccct tgcacctaat atgatggtaa caaacaatac     2700

cttcacactc aaaggcggtg caccaacaaa ggttactttt ggtgatgaca ctgtgataga     2760

agtgcaaggt tacaagagtg tgaatatcac ttttgaactt gatgaaagga ttgataaagt     2820

acttaatgag aagtgctctg cctatacagt tgaactcggt acagaagtaa atgagttcgc     2880

ctgtgttgtg gcagatgctg tcataaaaac tttgcaacca gtatctgaat tacttacacc     2940

actgggcatt gatttagatg agtggagtat ggctacatac tacttatttg atgagtctgg     3000

tgagtttaaa ttggcttcac atatgtattg ttctttctac cctccagatg aggatgaaga     3060

agaaggtgat tgtgaagaag aagagtttga gccatcaact caatatgagt atggtactga     3120

agatgattac caaggtaaac ctttggaatt tggtgccact tctgctgctc ttcaacctga     3180

agaagagcaa gaagaagatt ggttagatga tgatagtcaa caaactgttg gtcaacaaga     3240

cggcagtgag gacaatcaga caactactat tcaaacaatt gttgaggttc aacctcaatt     3300

agagatggaa cttacaccag ttgttcagac tattgaagtg aatagtttta gtggttattt     3360

aaaacttact gacaatgtat acattaaaaa tgcagacatt gtggaagaag ctaaaaaggt     3420

aaaaccaaca gtggttgtta atgcagccaa tgtttacctt aaacatggag gaggtgttgc     3480

aggagcctta aataaggcta ctaacaatgc catgcaagtt gaatctgatg attacatagc     3540

tactaatgga ccacttaaag tgggtggtag ttgtgtttta agcggacaca atcttgctaa     3600

acactgtctt catgttgtcg gcccaaatgt taacaaaggt gaagacattc aacttcttaa     3660

gagtgcttat gaaaatttta atcagcacga agttctactt gcaccattat tatcagctgg     3720

tatttttggt gctgacccta tacattcttt aagagtttgt gtagatactg ttcgcacaaa     3780

tgtctactta gctgtctttg ataaaaatct ctatgacaaa cttgtttcaa gctttttgga     3840

aatgaagagt gaaaagcaag ttgaacaaaa gatcgctgag attcctaaag aggaagttaa     3900

gccatttata actgaaagta aaccttcagt tgaacagaga aaacaagatg ataagaaaat     3960

caaagcttgt gttgaagaag ttacaacaac tctggaagaa actaagttcc tcacagaaaa     4020

cttgttactt tatattgaca ttaatggcaa tcttcatcca gattctgcca ctcttgttag     4080

tgacattgac atcactttct taaagaaaga tgctccatat atagtgggtg atgttgttca     4140

agagggtgtt ttaactgctg tggttatacc tactaaaaag gctggtggca ctactgaaat     4200

gctagcgaaa gctttgagaa aagtgccaac agacaattat ataaccactt acccgggtca     4260

gggtttaaat ggttacactg tagaggaggc aaagacagtg cttaaaaagt gtaaaagtgc     4320

cttttacatt ctaccatcta ttatctctaa tgagaagcaa gaaattcttg gaactgtttc     4380

ttggaatttg cgagaaatgc ttgcacatgc agaagaaaca cgcaaattaa tgcctgtctg     4440

tgtggaaact aaagccatag tttcaactat acagcgtaaa tataagggta ttaaaataca     4500

agagggtgtg gttgattatg gtgctagatt ttacttttac accagtaaaa caactgtagc     4560

gtcacttatc aacacactta acgatctaaa tgaaactctt gttacaatgc cacttggcta     4620

tgtaacacat ggcttaaatt tggaagaagc tgctcggtat atgagatctc tcaaagtgcc     4680

agctacagtt tctgtttctt cacctgatgc tgttacagcg tataatggtt atcttacttc     4740

ttcttctaaa acacctgaag aacattttat tgaaaccatc tcacttgctg gttcctataa     4800

agattggtcc tattctggac aatctacaca actaggtata gaatttctta agagaggtga     4860

taaaagtgta tattacacta gtaatcctac cacattccac ctagatggtg aagttatcac     4920

ctttgacaat cttaagacac ttctttcttt gagagaagtg aggactatta aggtgtttac     4980

aacagtagac aacattaacc tccacacgca agttgtggac atgtcaatga catatggaca     5040

acagtttggt ccaacttatt tggatggagc tgatgttact aaaataaaac ctcataattc     5100

acatgaaggt aaaacatttt atgttttacc taatgatgac actctacgtg ttgaggcttt     5160

tgagtactac cacacaactg atcctagttt tctgggtagg tacatgtcag cattaaatca     5220

cactaaaaag tggaaatacc cacaagttaa tggtttaact tctattaaat gggcagataa     5280

caactgttat cttgccactg cattgttaac actccaacaa atagagttga agtttaatcc     5340

acctgctcta caagatgctt attacagagc aagggctggt gaagctgcta acttttgtgc     5400

acttatctta gcctactgta ataagacagt aggtgagtta ggtgatgtta gagaaacaat     5460

gagttacttg tttcaacatg ccaatttaga ttcttgcaaa agagtcttga acgtggtgtg     5520

taaaacttgt ggacaacagc agacaaccct taagggtgta gaagctgtta tgtacatggg     5580

cacactttct tatgaacaat ttaagaaagg tgttcagata ccttgtacgt gtggtaaaca     5640

agctacaaaa tatctagtac aacaggagtc accttttgtt atgatgtcag caccacctgc     5700

tcagtatgaa cttaagcatg gtacatttac ttgtgctagt gagtacactg gtaattacca     5760

gtgtggtcac tataaacata taacttctaa agaaactttg tattgcatag acggtgcttt     5820

acttacaaag tcctcagaat acaaaggtcc tattacggat gttttctaca aagaaaacag     5880

ttacacaaca accataaaac cagttactta taaattggat ggtgttgttt gtacagaaat     5940

tgaccctaag ttggacaatt attataagaa agacaattct tatttcacag agcaaccaat     6000

tgatcttgta ccaaaccaac catatccaaa cgcaagcttc gataatttta agtttgtatg     6060

tgataatatc aaatttgctg atgatttaaa ccagttaact ggttataaga aacctgcttc     6120

aagagagctt aaagttacat ttttccctga cttaaatggt gatgtggtgg ctattgatta     6180

taaacactac acaccctctt ttaagaaagg agctaaattg ttacataaac ctattgtttg     6240

gcatgttaac aatgcaacta ataaagccac gtataaacca aatacctggt gtatacgttg     6300

tctttggagc acaaaaccag ttgaaacatc aaattcgttt gatgtactga agtcagagga     6360

cgcgcaggga atggataatc ttgcctgcga agatctaaaa ccagtctctg aagaagtagt     6420

ggaaaatcct accatacaga aagacgttct tgagtgtaat gtgaaaacta ccgaagttgt     6480

aggagacatt atacttaaac cagcaaataa tagtttaaaa attacagaag aggttggcca     6540

cacagatcta atggctgctt atgtagacaa ttctagtctt actattaaga aacctaatga     6600

attatctaga gtattaggtt tgaaaaccct tgctactcat ggtttagctg ctgttaatag     6660

tgtcccttgg gatactatag ctaattatgc taagcctttt cttaacaaag ttgttagtac     6720

aactactaac atagttacac ggtgtttaaa ccgtgtttgt actaattata tgccttattt     6780

ctttacttta ttgctacaat tgtgtacttt tactagaagt acaaattcta gaattaaagc     6840

atctatgccg actactatag caaagaatac tgttaagagt gtcggtaaat tttgtctaga     6900

ggcttcattt aattatttga agtcacctaa tttttctaaa ctgataaata ttataatttg     6960

gtttttacta ttaagtgttt gcctaggttc tttaatctac tcaaccgctg ctttaggtgt     7020

tttaatgtct aatttaggca tgccttctta ctgtactggt tacagagaag gctatttgaa     7080

ctctactaat gtcactattg caacctactg tactggttct ataccttgta gtgtttgtct     7140

tagtggttta gattctttag acacctatcc ttctttagaa actatacaaa ttaccatttc     7200

atcttttaaa tgggatttaa ctgcttttgg cttagttgca gagtggtttt tggcatatat     7260

tcttttcact aggtttttct atgtacttgg attggctgca atcatgcaat tgtttttcag     7320

ctattttgca gtacatttta ttagtaattc ttggcttatg tggttaataa ttaatcttgt     7380

acaaatggcc ccgatttcag ctatggttag aatgtacatc ttctttgcat cattttatta     7440

tgtatggaaa agttatgtgc atgttgtaga cggttgtaat tcatcaactt gtatgatgtg     7500

ttacaaacgt aatagagcaa caagagtcga atgtacaact attgttaatg gtgttagaag     7560

gtccttttat gtctatgcta atggaggtaa aggcttttgc aaactacaca attggaattg     7620

tgttaattgt gatacattct gtgctggtag tacatttatt agtgatgaag ttgcgagaga     7680

cttgtcacta cagtttaaaa gaccaataaa tcctactgac cagtcttctt acatcgttga     7740

tagtgttaca gtgaagaatg gttccatcca tctttacttt gataaagctg gtcaaaagac     7800

ttatgaaaga cattctctct ctcattttgt taacttagac aacctgagag ctaataacac     7860

taaaggttca ttgcctatta atgttatagt ttttgatggt aaatcaaaat gtgaagaatc     7920

atctgcaaaa tcagcgtctg tttactacag tcagcttatg tgtcaaccta tactgttact     7980

agatcaggca ttagtgtctg atgttggtga tagtgcggaa gttgcagtta aaatgtttga     8040

tgcttacgtt aatacgtttt catcaacttt taacgtacca atggaaaaac tcaaaacact     8100

agttgcaact gcagaagctg aacttgcaaa gaatgtgtcc ttagacaatg tcttatctac     8160

ttttatttca gcagctcggc aagggtttgt tgattcagat gtagaaacta aagatgttgt     8220

tgaatgtctt aaattgtcac atcaatctga catagaagtt actggcgata gttgtaataa     8280

ctatatgctc acctataaca aagttgaaaa catgacaccc cgtgaccttg gtgcttgtat     8340

tgactgtagt gcgcgtcata ttaatgcgca ggtagcaaaa agtcacaaca ttgctttgat     8400

atggaacgtt aaagatttca tgtcattgtc tgaacaacta cgaaaacaaa tacgtagtgc     8460

tgctaaaaag aataacttac cttttaagtt gacatgtgca actactagac aagttgttaa     8520

tgttgtaaca acaaagatag cacttaaggg tggtaaaatt gttaataatt ggttgaagca     8580

gttaattaaa gttacacttg tgttcctttt tgttgctgct attttctatt taataacacc     8640

tgttcatgtc atgtctaaac atactgactt ttcaagtgaa atcataggat acaaggctat     8700

tgatggtggt gtcactcgtg acatagcatc tacagatact tgttttgcta acaaacatgc     8760

tgattttgac acatggttta gccagcgtgg tggtagttat actaatgaca aagcttgccc     8820

attgattgct gcagtcataa caagagaagt gggttttgtc gtgcctggtt tgcctggcac     8880

gatattacgc acaactaatg gtgacttttt gcatttctta cctagagttt ttagtgcagt     8940

tggtaacatc tgttacacac catcaaaact tatagagtac actgactttg caacatcagc     9000

ttgtgttttg gctgctgaat gtacaatttt taaagatgct tctggtaagc cagtaccata     9060

ttgttatgat accaatgtac tagaaggttc tgttgcttat gaaagtttac gccctgacac     9120

acgttatgtg ctcatggatg gctctattat tcaatttcct aacacctacc ttgaaggttc     9180

tgttagagtg gtaacaactt ttgattctga gtactgtagg cacggcactt gtgaaagatc     9240

agaagctggt gtttgtgtat ctactagtgg tagatgggta cttaacaatg attattacag     9300

atctttacca ggagttttct gtggtgtaga tgctgtaaat ttacttacta atatgtttac     9360

accactaatt caacctattg gtgctttgga catatcagca tctatagtag ctggtggtat     9420

tgtagctatc gtagtaacat gccttgccta ctattttatg aggtttagaa gagcttttgg     9480

tgaatacagt catgtagttg cctttaatac tttactattc cttatgtcat tcactgtact     9540

ctgtttaaca ccagtttact cattcttacc tggtgtttat tctgttattt acttgtactt     9600

gacattttat cttactaatg atgtttcttt tttagcacat attcagtgga tggttatgtt     9660

cacaccttta gtacctttct ggataacaat tgcttatatc atttgtattt ccacaaagca     9720

tttctattgg ttctttagta attacctaaa gagacgtgta gtctttaatg gtgtttcctt     9780

tagtactttt gaagaagctg cgctgtgcac ctttttgtta aataaagaaa tgtatctaaa     9840

gttgcgtagt gatgtgctat tacctcttac gcaatataat agatacttag ctctttataa     9900

taagtacaag tattttagtg gagcaatgga tacaactagc tacagagaag ctgcttgttg     9960

tcatctcgca aaggctctca atgacttcag taactcaggt tctgatgttc tttaccaacc    10020

accacaaacc tctatcacct cagctgtttt gcagagtggt tttagaaaaa tggcattccc    10080

atctggtaaa gttgagggtt gtatggtaca agtaacttgt ggtacaacta cacttaacgg    10140

tctttggctt gatgacgtag tttactgtcc aagacatgtg atctgcacct ctgaagacat    10200

gcttaaccct aattatgaag atttactcat tcgtaagtct aatcataatt tcttggtaca    10260

ggctggtaat gttcaactca gggttattgg acattctatg caaaattgtg tacttaagct    10320

taaggttgat acagccaatc ctaagacacc taagtataag tttgttcgca ttcaaccagg    10380

acagactttt tcagtgttag cttgttacaa tggttcacca tctggtgttt accaatgtgc    10440

tatgaggccc aatttcacta ttaagggttc attccttaat ggttcatgtg gtagtgttgg    10500

ttttaacata gattatgact gtgtctcttt ttgttacatg caccatatgg aattaccaac    10560

tggagttcat gctggcacag acttagaagg taacttttat ggaccttttg ttgacaggca    10620

aacagcacaa gcagctggta cggacacaac tattacagtt aatgttttag cttggttgta    10680

cgctgctgtt ataaatggag acaggtggtt tctcaatcga tttaccacaa ctcttaatga    10740

ctttaacctt gtggctatga agtacaatta tgaacctcta acacaagacc atgttgacat    10800

actaggacct ctttctgctc aaactggaat tgccgtttta gatatgtgtg cttcattaaa    10860

agaattactg caaaatggta tgaatggacg taccatattg ggtagtgctt tattagaaga    10920

tgaatttaca ccttttgatg ttgttagaca atgctcaggt gttactttcc aaagtgcagt    10980

gaaaagaaca atcaagggta cacaccactg gttgttactc acaattttga cttcactttt    11040

agttttagtc cagagtactc aatggtcttt gttctttttt ttgtatgaaa atgccttttt    11100

accttttgct atgggtatta ttgctatgtc tgcttttgca atgatgtttg tcaaacataa    11160

gcatgcattt ctctgtttgt ttttgttacc ttctcttgcc actgtagctt attttaatat    11220

ggtctatatg cctgctagtt gggtgatgcg tattatgaca tggttggata tggttgatac    11280

tagtttgtct ggttttaagc taaaagactg tgttatgtat gcatcagctg tagtgttact    11340

aatccttatg acagcaagaa ctgtgtatga tgatggtgct aggagagtgt ggacacttat    11400

gaatgtcttg acactcgttt ataaagttta ttatggtaat gctttagatc aagccatttc    11460

catgtgggct cttataatct ctgttacttc taactactca ggtgtagtta caactgtcat    11520

gtttttggcc agaggtattg tttttatgtg tgttgagtat tgccctattt tcttcataac    11580

tggtaataca cttcagtgta taatgctagt ttattgtttc ttaggctatt tttgtacttg    11640

ttactttggc ctcttttgtt tactcaaccg ctactttaga ctgactcttg gtgtttatga    11700

ttacttagtt tctacacagg agtttagata tatgaattca cagggactac tcccacccaa    11760

gaatagcata gatgccttca aactcaacat taaattgttg ggtgttggtg gcaaaccttg    11820

tatcaaagta gccactgtac agtctaaaat gtcagatgta aagtgcacat cagtagtctt    11880

actctcagtt ttgcaacaac tcagagtaga atcatcatct aaattgtggg ctcaatgtgt    11940

ccagttacac aatgacattc tcttagctaa agatactact gaagcctttg aaaaaatggt    12000

ttcactactt tctgttttgc tttccatgca gggtgctgta gacataaaca agctttgtga    12060

agaaatgctg gacaacaggg caaccttaca agctatagcc tcagagttta gttcccttcc    12120

atcatatgca gcttttgcta ctgctcaaga agcttatgag caggctgttg ctaatggtga    12180

ttctgaagtt gttcttaaaa agttgaagaa gtctttgaat gtggctaaat ctgaatttga    12240

ccgtgatgca gccatgcaac gtaagttgga aaagatggct gatcaagcta tgacccaaat    12300

gtataaacag gctagatctg aggacaagag ggcaaaagtt actagtgcta tgcagacaat    12360

gcttttcact atgcttagaa agttggataa tgatgcactc aacaacatta tcaacaatgc    12420

aagagatggt tgtgttccct tgaacataat acctcttaca acagcagcca aactaatggt    12480

tgtcatacca gactataaca catataaaaa tacgtgtgat ggtacaacat ttacttatgc    12540

atcagcattg tgggaaatcc aacaggttgt agatgcagat agtaaaattg ttcaacttag    12600

tgaaattagt atggacaatt cacctaattt agcatggcct cttattgtaa cagctttaag    12660

ggccaattct gctgtcaaat tacagaataa tgagcttagt cctgttgcac tacgacagat    12720

gtcttgtgct gccggtacta cacaaactgc ttgcactgat gacaatgcgt tagcttacta    12780

caacacaaca aagggaggta ggtttgtact tgcactgtta tccgatttac aggatttgaa    12840

atgggctaga ttccctaaga gtgatggaac tggtactatc tatacagaac tggaaccacc    12900

ttgtaggttt gttacagaca cacctaaagg tcctaaagtg aagtatttat actttattaa    12960

aggattaaac aacctaaata gaggtatggt acttggtagt ttagctgcca cagtacgtct    13020

acaagctggt aatgcaacag aagtgcctgc caattcaact gtattatctt tctgtgcttt    13080

tgctgtagat gctgctaaag cttacaaaga ttatctagct agtgggggac aaccaatcac    13140

taattgtgtt aagatgttgt gtacacacac tggtactggt caggcaataa cagttacacc    13200

ggaagccaat atggatcaag aatcctttgg tggtgcatcg tgttgtctgt actgccgttg    13260

ccacatagat catccaaatc ctaaaggatt ttgtgactta aaaggtaagt atgtacaaat    13320

acctacaact tgtgctaatg accctgtggg ttttacactt aaaaacacag tctgtaccgt    13380

ctgcggtatg tggaaaggtt atggctgtag ttgtgatcaa ctccgcgaac ccatgcttca    13440

gtcagctgat gcacaatcgt ttttaaacgg gtttgcggtg taagtgcagc ccgtcttaca    13500

ccgtgcggca caggcactag tactgatgtc gtatacaggg cttttgacat ctacaatgat    13560

aaagtagctg gttttgctaa attcctaaaa actaattgtt gtcgcttcca agaaaaggac    13620

gaagatgaca atttaattga ttcttacttt gtagttaaga gacacacttt ctctaactac    13680

caacatgaag aaacaattta taatttactt aaggattgtc cagctgttgc taaacatgac    13740

ttctttaagt ttagaataga cggtgacatg gtaccacata tatcacgtca acgtcttact    13800

aaatacacaa tggcagacct cgtctatgct ttaaggcatt ttgatgaagg taattgtgac    13860

acattaaaag aaatacttgt cacatacaat tgttgtgatg atgattattt caataaaaag    13920

gactggtatg attttgtaga aaacccagat atattacgcg tatacgccaa cttaggtgaa    13980

cgtgtacgcc aagctttgtt aaaaacagta caattctgtg atgccatgcg aaatgctggt    14040

attgttggtg tactgacatt agataatcaa gatctcaatg gtaactggta tgatttcggt    14100

gatttcatac aaaccacgcc aggtagtgga gttcctgttg tagattctta ttattcattg    14160

ttaatgccta tattaacctt gaccagggct ttaactgcag agtcacatgt tgacactgac    14220

ttaacaaagc cttacattaa gtgggatttg ttaaaatatg acttcacgga agagaggtta    14280

aaactctttg accgttattt taaatattgg gatcagacat accacccaaa ttgtgttaac    14340

tgtttggatg acagatgcat tctgcattgt gcaaacttta atgttttatt ctctacagtg    14400

ttcccaccta caagttttgg accactagtg agaaaaatat ttgttgatgg tgttccattt    14460

gtagtttcaa ctggatacca cttcagagag ctaggtgttg tacataatca ggatgtaaac    14520

ttacatagct ctagacttag ttttaaggaa ttacttgtgt atgctgctga ccctgctatg    14580

cacgctgctt ctggtaatct attactagat aaacgcacta cgtgcttttc agtagctgca    14640

cttactaaca atgttgcttt tcaaactgtc aaacccggta attttaacaa agacttctat    14700

gactttgctg tgtctaaggg tttctttaag gaaggaagtt ctgttgaatt aaaacacttc    14760

ttctttgctc aggatggtaa tgctgctatc agcgattatg actactatcg ttataatcta    14820

ccaacaatgt gtgatatcag acaactacta tttgtagttg aagttgttga taagtacttt    14880

gattgttacg atggtggctg tattaatgct aaccaagtca tcgtcaacaa cctagacaaa    14940

tcagctggtt ttccatttaa taaatggggt aaggctagac tttattatga ttcaatgagt    15000

tatgaggatc aagatgcact tttcgcatat acaaaacgta atgtcatccc tactataact    15060

caaatgaatc ttaagtatgc cattagtgca aagaatagag ctcgcaccgt agctggtgtc    15120

tctatctgta gtactatgac caatagacag tttcatcaaa aattattgaa atcaatagcc    15180

gccactagag gagctactgt agtaattgga acaagcaaat tctatggtgg ttggcacaac    15240

atgttaaaaa ctgtttatag tgatgtagaa aaccctcacc ttatgggttg ggattatcct    15300

aaatgtgata gagccatgcc taacatgctt agaattatgg cctcacttgt tcttgctcgc    15360

aaacatacaa cgtgttgtag cttgtcacac cgtttctata gattagctaa tgagtgtgct    15420

caagtattga gtgaaatggt catgtgtggc ggttcactat atgttaaacc aggtggaacc    15480

tcatcaggag atgccacaac tgcttatgct aatagtgttt ttaacatttg tcaagctgtc    15540

acggccaatg ttaatgcact tttatctact gatggtaaca aaattgccga taagtatgtc    15600

cgcaatttac aacacagact ttatgagtgt ctctatagaa atagagatgt tgacacagac    15660

tttgtgaatg agttttacgc atatttgcgt aaacatttct caatgatgat actctctgac    15720

gatgctgttg tgtgtttcaa tagcacttat gcatctcaag gtctagtggc tagcataaag    15780

aactttaagt cagttcttta ttatcaaaac aatgttttta tgtctgaagc aaaatgttgg    15840

actgagactg accttactaa aggacctcat gaattttgct ctcaacatac aatgctagtt    15900

aaacagggtg atgattatgt gtaccttcct tacccagatc catcaagaat cctaggggcc    15960

ggctgttttg tagatgatat cgtaaaaaca gatggtacac ttatgattga acggttcgtg    16020

tctttagcta tagatgctta cccacttact aaacatccta atcaggagta tgctgatgtc    16080

tttcatttgt acttacaata cataagaaag ctacatgatg agttaacagg acacatgtta    16140

gacatgtatt ctgttatgct tactaatgat aacacttcaa ggtattggga acctgagttt    16200

tatgaggcta tgtacacacc gcatacagtc ttacaggctg ttggggcttg tgttctttgc    16260

aattcacaga cttcattaag atgtggtgct tgcatacgta gaccattctt atgttgtaaa    16320

tgctgttacg accatgtcat atcaacatca cataaattag tcttgtctgt taatccgtat    16380

gtttgcaatg ctccaggttg tgatgtcaca gatgtgactc aactttactt aggaggtatg    16440

agctattatt gtaaatcaca taaaccaccc attagttttc cattgtgtgc taatggacaa    16500

gtttttggtt tatataaaaa tacatgtgtt ggtagcgata atgttactga ctttaatgca    16560

attgcaacat gtgactggac aaatgctggt gattacattt tagctaacac ctgtactgaa    16620

agactcaagc tttttgcagc agaaacgctc aaagctactg aggagacatt taaactgtct    16680

tatggtattg ctactgtacg tgaagtgctg tctgacagag aattacatct ttcatgggaa    16740

gttggtaaac ctagaccacc acttaaccga aattatgtct ttactggtta tcgtgtaact    16800

aaaaacagta aagtacaaat aggagagtac acctttgaaa aaggtgacta tggtgatgct    16860

gttgtttacc gaggtacaac aacttacaaa ttaaatgttg gtgattattt tgtgctgaca    16920

tcacatacag taatgccatt aagtgcacct acactagtgc cacaagagca ctatgttaga    16980

attactggct tatacccaac actcaatatc tcagatgagt tttctagcaa tgttgcaaat    17040

tatcaaaagg ttggtatgca aaagtattct acactccagg gaccacctgg tactggtaag    17100

agtcattttg ctattggcct agctctctac tacccttctg ctcgcatagt gtatacagct    17160

tgctctcatg ccgctgttga tgcactatgt gagaaggcat taaaatattt gcctatagat    17220

aaatgtagta gaattatacc tgcacgtgct cgtgtagagt gttttgataa attcaaagtg    17280

aattcaacat tagaacagta tgtcttttgt actgtaaatg cattgcctga gacgacagca    17340

gatatagttg tctttgatga aatttcaatg gccacaaatt atgatttgag tgttgtcaat    17400

gccagattac gtgctaagca ctatgtgtac attggcgacc ctgctcaatt acctgcacca    17460

cgcacattgc taactaaggg cacactagaa ccagaatatt tcaattcagt gtgtagactt    17520

atgaaaacta taggtccaga catgttcctc ggaacttgtc ggcgttgtcc tgctgaaatt    17580

gttgacactg tgagtgcttt ggtttatgat aataagctta aagcacataa agacaaatca    17640

gctcaatgct ttaaaatgtt ttataagggt gttatcacgc atgatgtttc atctgcaatt    17700

aacaggccac aaataggcgt ggtaagagaa ttccttacac gtaaccctgc ttggagaaaa    17760

gctgtcttta tttcacctta taattcacag aatgctgtag cctcaaagat tttgggacta    17820

ccaactcaaa ctgttgattc atcacagggc                                     17850


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  2
tggatgatcg gtggagtgta                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
cacacacgag gacaaacacc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
aaggcacacc ataaggctga                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
tcgtagagct tgccatcgtt                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
tcgaaatgaa agttccagca                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
tgtgtgaggg acactcctta c                                                 21


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
cccaccctcc tcaatgacac                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
gcactgggaa tctcatggca                                                   20


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
agcacagtgg tgaaagagac ctt                                               23


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
tccaatgcat agctggtgat tt                                                22


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
cctggctctt gcttgcctt                                                    19


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
ggtcttgtgt gatgttgctc a                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
cagtacagcc ccaaaatggt                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
caagggcata tccaacaaca                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
tgttcctacc cccaatgtgt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
ggtcctcagt gtagcccaag                                                   20


<210>  18
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Glu Gly Phe Arg Asp Arg Ala Ala Phe Ile Arg Gly Ala Lys 
1               5                   10                  15      


Asp Ile Ala Lys Glu Val Lys Lys His Ala Ala Lys Lys Val Val Lys 
            20                  25                  30          


Gly Leu Asp Arg Val Gln Asp Glu Tyr Ser Arg Arg Ser Tyr Ser Arg 
        35                  40                  45              


Phe Glu Glu Glu Asp Asp Asp Asp Asp Phe Pro Ala Pro Ser Asp Gly 
    50                  55                  60                  


Tyr Tyr Arg Gly Glu Gly Thr Gln Asp Glu Glu Glu Gly Gly Ala Ser 
65                  70                  75                  80  


Ser Asp Ala Thr Glu Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly 
                85                  90                  95      


Glu Tyr Gln Gly Ile Pro Arg Ala Glu Ser Gly Gly Lys Gly Glu Arg 
            100                 105                 110         


Met Ala Asp Gly Ala Pro Leu Ala Gly Val Arg Gly Gly Leu Ser Asp 
        115                 120                 125             


Gly Glu Gly Pro Pro Gly Gly Arg Gly Glu Ala Gln Arg Arg Lys Glu 
    130                 135                 140                 


Arg Glu Glu Leu Ala Gln Gln Tyr Glu Ala Ile Leu Arg Glu Cys Gly 
145                 150                 155                 160 


His Gly Arg Phe Gln Trp Thr Leu Tyr Phe Val Leu Gly Leu Ala Leu 
                165                 170                 175     


Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu Pro Ser 
            180                 185                 190         


Ala Glu Lys Asp Met Cys Leu Ser Asp Ser Asn Lys Gly Met Leu Gly 
        195                 200                 205             


Leu Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Leu Trp Gly Gly 
    210                 215                 220                 


Leu Ala Asp Arg Leu Gly Arg Arg Gln Cys Leu Leu Ile Ser Leu Ser 
225                 230                 235                 240 


Val Asn Ser Val Phe Ala Phe Phe Ser Ser Phe Val Gln Gly Tyr Gly 
                245                 250                 255     


Thr Phe Leu Phe Cys Arg Leu Leu Ser Gly Val Gly Ile Gly Gly Ser 
            260                 265                 270         


Ile Pro Ile Val Phe Ser Tyr Phe Ser Glu Phe Leu Ala Gln Glu Lys 
        275                 280                 285             


Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile Gly Gly 
    290                 295                 300                 


Val Tyr Ala Ala Ala Met Ala Trp Ala Ile Ile Pro His Tyr Gly Trp 
305                 310                 315                 320 


Ser Phe Gln Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg Val Phe 
                325                 330                 335     


Val Leu Val Cys Ala Phe Pro Ser Val Phe Ala Ile Gly Ala Leu Thr 
            340                 345                 350         


Thr Gln Pro Glu Ser Pro Arg Phe Phe Leu Glu Asn Gly Lys His Asp 
        355                 360                 365             


Glu Ala Trp Met Val Leu Lys Gln Val His Asp Thr Asn Met Arg Ala 
    370                 375                 380                 


Lys Gly His Pro Glu Arg Val Phe Ser Val Thr His Ile Lys Thr Ile 
385                 390                 395                 400 


His Gln Glu Asp Glu Leu Ile Glu Ile Gln Ser Asp Thr Gly Thr Trp 
                405                 410                 415     


Tyr Gln Arg Trp Gly Val Arg Ala Leu Ser Leu Gly Gly Gln Val Trp 
            420                 425                 430         


Gly Asn Phe Leu Ser Cys Phe Gly Pro Glu Tyr Arg Arg Ile Thr Leu 
        435                 440                 445             


Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr Tyr Gly Leu 
    450                 455                 460                 


Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala Val Asp Tyr 
465                 470                 475                 480 


Ala Ser Arg Thr Lys Val Phe Pro Gly Glu Arg Val Glu His Val Thr 
                485                 490                 495     


Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly Gln Tyr Phe 
            500                 505                 510         


Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser Phe Glu Asp 
        515                 520                 525             


Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser Ser Asn Thr 
    530                 535                 540                 


Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr Asn Thr Asp 
545                 550                 555                 560 


Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Ile Asn Ser Thr Phe 
                565                 570                 575     


Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly Thr Gly Glu 
            580                 585                 590         


Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr Leu Ala Val 
        595                 600                 605             


Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Lys Ile Gly Arg 
    610                 615                 620                 


Leu Arg Met Leu Ala Gly Ser Ser Val Met Ser Cys Val Ser Cys Phe 
625                 630                 635                 640 


Phe Leu Ser Phe Gly Asn Ser Glu Ser Ala Met Ile Ala Leu Leu Cys 
                645                 650                 655     


Leu Phe Gly Gly Val Ser Ile Ala Ser Trp Asn Ala Leu Asp Val Leu 
            660                 665                 670         


Thr Val Glu Leu Tyr Pro Ser Asp Lys Arg Thr Thr Ala Phe Gly Phe 
        675                 680                 685             


Leu Asn Ala Leu Cys Lys Leu Ala Ala Val Leu Gly Ile Ser Ile Phe 
    690                 695                 700                 


Thr Ser Phe Val Gly Ile Thr Lys Ala Ala Pro Ile Leu Phe Ala Ser 
705                 710                 715                 720 


Ala Ala Leu Ala Leu Gly Ser Ser Leu Ala Leu Lys Leu Pro Glu Thr 
                725                 730                 735     


Arg Gly Gln Val Leu Gln 
            740         


<210>  19
<211>  4378
<212>  DNA
<213>  Homo sapiens

<400>  19
gcattgccgc ttccctggtg ccgggagcag tcgccgctgc cgcctccgcc cgcggccggg       60

acccccgtcc tcgcccggga ctccttaccc ggggaaccta gaccaggtct ccagaggctt      120

gtggaagaga agcaggcgac ccttcctgag ttatcctggc ttagcctccc aatctggctc      180

cccttcccct tcccattccc ctgctccccc tgtcccttcc ccatccaccc aactgaactg      240

ggtataggtc aaagctcctc tccttccttt tccttcctag gcactcattg gctaggacct      300

gtttgctctt ttttttgtgc ccagagatac tggaacacgc ttcatctaag taactgtggg      360

gaggggtctt tttgactcta caagtccttg agcaaaaagc tgaaaaagaa gcaggaggtg      420

gagaagaccc agtgaagtgc cccaagcccc atcatggaag agggcttccg agaccgggca      480

gctttcatcc gtggggccaa agacattgct aaggaagtca aaaagcatgc ggccaagaag      540

gtggtgaagg gcctggacag agtccaggac gaatattccc gaagatcgta ctcccgcttt      600

gaggaggagg atgatgatga tgacttccct gctcccagtg atggttatta ccgaggagaa      660

gggacccagg atgaggagga aggtggtgca tccagtgatg ctactgaggg ccatgacgag      720

gatgatgaga tctatgaagg ggaatatcag ggcattcccc gggcagagtc tgggggcaaa      780

ggcgagcgga tggcagatgg ggcgcccctg gctggagtaa gggggggctt gagtgatggg      840

gagggtcccc ctgggggccg gggggaggca caacgacgga aagaacgaga agaactggcc      900

caacagtatg aagccatcct acgggagtgt ggccacggcc gcttccagtg gacactgtat      960

tttgtgcttg gtctggcgct gatggctgac ggtgtggagg tctttgtggt gggcttcgtg     1020

ctgcccagcg ctgagaaaga catgtgcctg tccgactcca acaaaggcat gctaggcctc     1080

atcgtctacc tgggcatgat ggtgggagcc ttcctctggg gaggtctggc tgaccggctg     1140

ggtcggaggc agtgtctgct catctcgctc tcagtcaaca gcgtcttcgc cttcttctca     1200

tcttttgtcc agggttacgg cactttcctc ttctgccgcc tactttctgg ggttgggatt     1260

ggagggtcca tccccattgt cttctcctat ttctccgagt ttctggccca ggagaaacga     1320

ggggagcatt tgagctggct ctgcatgttt tggatgattg gtggcgtgta cgcagctgct     1380

atggcctggg ccatcatccc ccactatggg tggagttttc agatgggttc tgcctaccag     1440

ttccacagct ggagggtctt cgtcctcgtc tgcgcctttc cttctgtgtt tgccattggg     1500

gctctgacca cgcagcctga gagcccccgt ttcttcctag agaatggaaa gcatgatgag     1560

gcctggatgg tgctgaagca ggtccatgat accaacatgc gagccaaagg acatcctgag     1620

cgagtgttct cagtaaccca cattaagacg attcatcagg aggatgaatt gattgagatc     1680

cagtcggaca cagggacctg gtaccagcgc tggggggtcc gggccttgag cctagggggg     1740

caggtttggg ggaattttct ctcctgtttt ggtcccgaat atcggcgcat cactctgatg     1800

atgatgggtg tgtggttcac catgtcattc agctactatg gcctgaccgt ctggtttcct     1860

gacatgatcc gccatctcca ggcagtggac tacgcatccc gcaccaaagt gttccccggg     1920

gagcgcgtag agcatgtaac ttttaacttc acgttggaga atcagatcca ccgaggcggg     1980

cagtacttca atgacaagtt cattgggctg cggctcaagt cagtgtcctt tgaggattcc     2040

ctgtttgaag agtgttattt tgaggatgtc acatccagca acacgttttt ccgcaactgc     2100

acattcatca acactgtgtt ctataacact gacctgttcg agtacaagtt tgtgaacagc     2160

cgtctgataa acagtacatt cctgcacaac aaggagggct gcccgctaga cgtgacaggg     2220

acgggcgaag gtgcctacat ggtatacttt gtgagcttcc tggggacact ggcagtgctt     2280

cctgggaata tcgtgtctgc cctgctcatg gacaagatcg gcaggctcag aatgcttgct     2340

ggctccagcg tgatgtcctg tgtctcctgc ttcttcctgt cttttgggaa cagtgagtcg     2400

gccatgatcg ctctgctctg cctttttggc ggggtcagca ttgcatcctg gaatgcgctg     2460

gacgtgttga ctgttgaact ctacccctca gacaagagga ccacagcttt tggcttcctg     2520

aatgccctgt gtaagctggc agctgtgctg gggatcagca tcttcacatc cttcgtggga     2580

atcaccaagg ctgcacccat cctctttgcc tcagctgccc ttgcccttgg cagctctctg     2640

gccctgaagc tgcctgagac ccgggggcag gtgctgcagt gaaggggtct ctagggcttt     2700

gggattggca ggcacactgt gagaccaaca actccttcct tcccctccct gccctgccat     2760

cctgacctcc agagccctca ctccccactc cccgtgtttg gtgtcttagc tgtgtgtgcg     2820

tgtgcgtgtg catgtgtgta aaccccgtgg gcagggacta cagggaaggc tccttcatcc     2880

cagttttgag atgaagctgt actccccatt tcccactgcc cttgactttg cacaagagaa     2940

ggctgagccc catccttctc cccctgttag agaggggccc ttgcttccct gttccagggg     3000

ttccagaata ggcttcctgc cttccccatc attccctctg cctaggccct ggtgaaacca     3060

caggtatgca attatgctag gggctggggc tctggtgtag accatggacc aaaagaactt     3120

cttagagtct gaagagtggg cctcgggtgc cctctcacat ctcctgttgg atgctggggg     3180

agaagcaata aacctcagcc ctctggcctc cactttcctc tcaatttggg ctgcaaatat     3240

gaagcctgaa ttttatgaaa ttagctttct gattcttatt tattaataga ttaagttctg     3300

aggcagctcc gcaggactgt gtgtgaatgt gtatgtatac ttacatatgt gtgtgcatgt     3360

gccatggggc ggggggtatc actatactgt cctcaaatat aagccaaggg taatttcagc     3420

ggatgcacac acaaccctgc ctcccacagt tcctccccta atctggtttc tgtgttgagc     3480

ctgggatgga ggagccctag gccagcctgg gataagagtc ccacagtcta gggagatctg     3540

agggcatccg acaaggccca tctccttccc tcctcaagaa gcagaggcct cctctggagt     3600

gagaggctcc acccactaca gcacaggcgg gaatagcaca gctgccctcc catgctccct     3660

acctgtcccc tcacagggag gggagcaggg gagggaaaga aaccaggcat ctggtcaaac     3720

cagcagatca aaaagcacaa agagctgggg cagaggcagg aagcaggggc cctcctggca     3780

gctcctctga gtggggagag gttgggcagt gagtgaggga cccctaatgc agggactaga     3840

agcctcagtt tccccatttt acccttccac acaatagcct ctgtaggtta ggctgcccca     3900

tcccacccta ctctgtgtgg ctgctttctt tggtgccctc ccctcacccc actgtagctg     3960

tgacgtgttg tagtttttag atgtttgtaa aatgtttaaa aaaatgttaa aaggaaaaaa     4020

gtgaaaataa caaaaaagaa aatcaaaatt caccttcgtc atgctgcgtc cagtgcccca     4080

accctgtggt cactctcccc attttgtaac actgtaccag gtggtgactg tttaactctt     4140

tggtgtctgt gctcaaaaga ctgccttctc cagtgcccag tgtatgagtg tgtgccctgt     4200

gcccttgtcc ctcactcccc acatgctgga cgtagccctc ttcctcgcac ccctgggagg     4260

gacccatcca tctcccttgc tctcctgggg aaccctaaac ccaactctgt tgatgtgaaa     4320

aatgcagtga aaaatattga cgaaaaataa aacggaaaca aatcctcaaa atacaaaa       4378


<210>  20
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Asp Tyr Lys Tyr Gln Asp Asn Tyr Gly Gly Tyr Ala Pro Ser 
1               5                   10                  15      


Asp Gly Tyr Tyr Arg Gly Asn Glu Ser Asn Pro Glu Glu Asp Ala Gln 
            20                  25                  30          


Ser Asp Val Thr Glu Gly His Asp Glu Glu Asp Glu Ile Tyr Glu Gly 
        35                  40                  45              


Glu Tyr Gln Gly Ile Pro His Pro Asp Asp Val Lys Ala Lys Gln Ala 
    50                  55                  60                  


Lys Met Ala Pro Ser Arg Met Asp Ser Leu Arg Gly Gln Thr Asp Leu 
65                  70                  75                  80  


Met Ala Glu Arg Leu Glu Asp Glu Glu Gln Leu Ala His Gln Tyr Glu 
                85                  90                  95      


Thr Ile Met Asp Glu Cys Gly His Gly Arg Phe Gln Trp Ile Leu Phe 
            100                 105                 110         


Phe Val Leu Gly Leu Ala Leu Met Ala Asp Gly Val Glu Val Phe Val 
        115                 120                 125             


Val Ser Phe Ala Leu Pro Ser Ala Glu Lys Asp Met Cys Leu Ser Ser 
    130                 135                 140                 


Ser Lys Lys Gly Met Leu Gly Met Ile Val Tyr Leu Gly Met Met Ala 
145                 150                 155                 160 


Gly Ala Phe Ile Leu Gly Gly Leu Ala Asp Lys Leu Gly Arg Lys Arg 
                165                 170                 175     


Val Leu Ser Met Ser Leu Ala Val Asn Ala Ser Phe Ala Ser Leu Ser 
            180                 185                 190         


Ser Phe Val Gln Gly Tyr Gly Ala Phe Leu Phe Cys Arg Leu Ile Ser 
        195                 200                 205             


Gly Ile Gly Ile Gly Gly Ala Leu Pro Ile Val Phe Ala Tyr Phe Ser 
    210                 215                 220                 


Glu Phe Leu Ser Arg Glu Lys Arg Gly Glu His Leu Ser Trp Leu Gly 
225                 230                 235                 240 


Ile Phe Trp Met Thr Gly Gly Leu Tyr Ala Ser Ala Met Ala Trp Ser 
                245                 250                 255     


Ile Ile Pro His Tyr Gly Trp Gly Phe Ser Met Gly Thr Asn Tyr His 
            260                 265                 270         


Phe His Ser Trp Arg Val Phe Val Ile Val Cys Ala Leu Pro Cys Thr 
        275                 280                 285             


Val Ser Met Val Ala Leu Lys Phe Met Pro Glu Ser Pro Arg Phe Leu 
    290                 295                 300                 


Leu Glu Met Gly Lys His Asp Glu Ala Trp Met Ile Leu Lys Gln Val 
305                 310                 315                 320 


His Asp Thr Asn Met Arg Ala Lys Gly Thr Pro Glu Lys Val Phe Thr 
                325                 330                 335     


Val Ser Asn Ile Lys Thr Pro Lys Gln Met Asp Glu Phe Ile Glu Ile 
            340                 345                 350         


Gln Ser Ser Thr Gly Thr Trp Tyr Gln Arg Trp Leu Val Arg Phe Lys 
        355                 360                 365             


Thr Ile Phe Lys Gln Val Trp Asp Asn Ala Leu Tyr Cys Val Met Gly 
    370                 375                 380                 


Pro Tyr Arg Met Asn Thr Leu Ile Leu Ala Val Val Trp Phe Ala Met 
385                 390                 395                 400 


Ala Phe Ser Tyr Tyr Gly Leu Thr Val Trp Phe Pro Asp Met Ile Arg 
                405                 410                 415     


Tyr Phe Gln Asp Glu Glu Tyr Lys Ser Lys Met Lys Val Phe Phe Gly 
            420                 425                 430         


Glu His Val Tyr Gly Ala Thr Ile Asn Phe Thr Met Glu Asn Gln Ile 
        435                 440                 445             


His Gln His Gly Lys Leu Val Asn Asp Lys Phe Thr Arg Met Tyr Phe 
    450                 455                 460                 


Lys His Val Leu Phe Glu Asp Thr Phe Phe Asp Glu Cys Tyr Phe Glu 
465                 470                 475                 480 


Asp Val Thr Ser Thr Asp Thr Tyr Phe Lys Asn Cys Thr Ile Glu Ser 
                485                 490                 495     


Thr Ile Phe Tyr Asn Thr Asp Leu Tyr Glu His Lys Phe Ile Asn Cys 
            500                 505                 510         


Arg Phe Ile Asn Ser Thr Phe Leu Glu Gln Lys Glu Gly Cys His Met 
        515                 520                 525             


Asp Leu Glu Gln Asp Asn Asp Phe Leu Ile Tyr Leu Val Ser Phe Leu 
    530                 535                 540                 


Gly Ser Leu Ser Val Leu Pro Gly Asn Ile Ile Ser Ala Leu Leu Met 
545                 550                 555                 560 


Asp Arg Ile Gly Arg Leu Lys Met Ile Gly Gly Ser Met Leu Ile Ser 
                565                 570                 575     


Ala Val Cys Cys Phe Phe Leu Phe Phe Gly Asn Ser Glu Ser Ala Met 
            580                 585                 590         


Ile Gly Trp Gln Cys Leu Phe Cys Gly Thr Ser Ile Ala Ala Trp Asn 
        595                 600                 605             


Ala Leu Asp Val Ile Thr Val Glu Leu Tyr Pro Thr Asn Gln Arg Ala 
    610                 615                 620                 


Thr Ala Phe Gly Ile Leu Asn Gly Leu Cys Lys Phe Gly Ala Ile Leu 
625                 630                 635                 640 


Gly Asn Thr Ile Phe Ala Ser Phe Val Gly Ile Thr Lys Val Val Pro 
                645                 650                 655     


Ile Leu Leu Ala Ala Ala Ser Leu Val Gly Gly Gly Leu Ile Ala Leu 
            660                 665                 670         


Arg Leu Pro Glu Thr Arg Glu Gln Val Leu Met 
        675                 680             


<210>  21
<211>  12651
<212>  DNA
<213>  Homo sapiens

<400>  21
gcccggatcg cccagctccg cgttagccgg agctgcacgc ggggctgccg gggcggacgc       60

tgctctgcct gcatccggag gcggccgcca gcggatttgc cacccaggtc ctaagactct      120

cagtccagag agggccctgc cccacaccca gaaggaagga atgctgccca gagatgacca      180

gaggaatcta gacagagcat aaccttcggt ggcaggacaa atcaggccag cacgcagtct      240

gccaagtcct gctcgctccc tgtcaagaaa aacagctgga tccatttcta atcaacactt      300

cccaacgcaa cacttctgag tctctgaagg agaccagagc ttgaaacttt ccagacttcc      360

aacagacatc gagtgcaaaa ggatatttag gttgtctttg cacaaatctg gttgatttga      420

gagataaagg gggggggaac cagtgtgact ttcacctaag aagtcacatg aacatatttc      480

acatttgaac tacataatga atgatggtta ttgaaatagc ccaaacctct accacagagc      540

gagggatata gctcaagggg caaccaggca gtcgcagaac caaggaatgg atgactacaa      600

gtatcaggac aattatgggg gctatgctcc cagtgatggc tattaccgcg gcaatgagtc      660

caacccagaa gaagatgcac agagtgatgt caccgaaggc catgatgagg aagacgagat      720

ctatgagggc gagtaccagg gtatccctca cccagatgat gtcaaggcca agcaggccaa      780

gatggcgccc tccagaatgg acagccttcg gggccagaca gacctgatgg ctgagaggct      840

ggaagatgag gagcagttgg cccaccagta cgagaccatc atggatgagt gtggccatgg      900

ccgcttccag tggatcctct ttttcgtctt gggtttggcc ctgatggccg atggggtgga      960

agtgttcgtg gtgagttttg ccctgcccag tgcagagaag gacatgtgtc tgtccagttc     1020

caaaaaagga atgctaggga tgatagtcta cttgggaatg atggcgggcg ccttcatcct     1080

gggaggcctg gctgataagc tgggaaggaa gcgagtcctc agcatgtctc tggccgtcaa     1140

tgcctccttc gcctccctct cttccttcgt gcagggatat ggagccttcc tcttctgccg     1200

actcatctca ggcatcggta ttgggggtgc tctaccgatt gtttttgcct atttttctga     1260

attcttgtct cgggagaagc gaggagaaca cctcagttgg ctgggcatct tctggatgac     1320

tgggggcctg tacgcatctg ccatggcctg gagcatcatc ccacactatg gctggggctt     1380

cagcatgggg accaattacc acttccatag ctggagagtg tttgtcatcg tctgtgctct     1440

gccctgcacc gtgtccatgg tggccctgaa gttcatgcca gagagcccaa ggtttctgct     1500

agagatgggc aaacatgatg aagcctggat gattctcaag caagtccatg acaccaacat     1560

gagagctaag gggaccccag agaaagtgtt cacggtttcc aacatcaaaa ctcccaagca     1620

aatggatgaa ttcattgaga tccaaagttc aacaggaacc tggtaccagc gctggctggt     1680

cagattcaag accattttca agcaggtctg ggataatgcc ctgtactgtg tgatggggcc     1740

ctacagaatg aatacactga ttctggccgt ggtttggttt gccatggcat tcagttacta     1800

tggactgaca gtttggtttc ctgatatgat ccgctatttt caagatgaag aatacaagtc     1860

taaaatgaag gtgttttttg gtgagcatgt gtacggcgcc acaatcaact tcacgatgga     1920

aaatcagatc caccaacatg ggaaacttgt gaatgataag ttcacaagaa tgtactttaa     1980

acatgtactc tttgaggaca cattctttga cgagtgctat tttgaagacg taacatcaac     2040

agatacctac ttcaaaaatt gtaccattga atcaaccatc ttttacaaca cagacctcta     2100

cgagcacaag ttcatcaact gtcggtttat caactccacc ttcctggagc agaaggaggg     2160

ctgccacatg gacttggagc aagataatga cttcctgatt tacctcgtca gcttcctggg     2220

cagcctgtct gtcttacccg ggaacatcat ttctgccctg ctcatggata gaattggaag     2280

gctcaagatg attggtggct ccatgctaat ctctgcagtc tgctgcttct tcctgttttt     2340

tggcaacagt gagtctgcaa tgatcggctg gcagtgcctg ttctgtggga caagcattgc     2400

agcctggaat gctctggatg tgatcacagt ggagctgtat cccaccaacc agagagcaac     2460

agccttcggc attctcaatg gattatgcaa atttggcgcc atcctgggaa acaccatctt     2520

tgcttctttt gttgggataa ccaaagtggt ccccatcctt ctggctgctg cttctctggt     2580

tgggggtggc ctgattgccc ttcgactgcc agagactcga gaacaggtcc tgatgtgaac     2640

aacctatggg aaaaggaaag gtcgagagaa tcttgtccag gacactgaaa tgcatccaca     2700

cttcctgcct atcacggtcc ggaggacacc ttggatagca cgggaggaga agttgacttt     2760

gtgaccccta gtttaggacc cacttcagct gtcaatatgt ttgtaactca ggtgactgat     2820

ttgggggtgc cctgagccac ccttagaatc acagagctgc gtgtttaact tcaagtcttc     2880

ccagtccaag gcagggagag gattctccag tgagtgcaca cactatgcga ggagcaagca     2940

tttctctaag tcaagtgcaa ggacttaact tgcgtttgaa aaggaattag agggtcagaa     3000

acacccaggt tcctccagaa agctccttgg agcccaacaa cttaacaaat caacttggct     3060

ggaagttaga gtcattatat gaagattggg cttgaagtat atatttttgc atttaaaagt     3120

atcacctatc atattttcca ctcgaaaatt gacatagtag cattgaggat actctgatct     3180

agaaagccaa gtatttgagc aacatctata gagatctact tttctcctat gtctcctagg     3240

ctttccatga taattaggta atacatttaa gaaggatatt tatttctgtt ttgctctatt     3300

caaagaaacg gaatgggata gttattctgt aaactaagtt tgtatataac tttatttggg     3360

tttaatttcc acaactggta tctgcaaata ttgccagcat tttagccata ttttgggaga     3420

acttggtgtt tgaggtccca ggaaatgagg tctgatcaaa tgaaatgcaa gcacaatttc     3480

ttacagccat ttaactttct gttgggagga tgaattaaca aactcacatt gtgcagtctg     3540

cttaatccag gcacttttct ttgtgcaggt gtagtgagta gttacttctc tcccttacac     3600

agatgacttg tgaaactcaa gctcaccatc ttcagtgctg gcattttact ttgccactac     3660

ccaaaaacaa tgtgagatgt gttcagtggc ctctggtact ctttgcaggc aagaatcaaa     3720

caacatgggg actgagggaa ggatggggaa gtgtagccac agttcttcca aatgtaaata     3780

ctttttgttt gttctagtgg taaaatgcaa atgcaatcca tatttgttag gatggtcagg     3840

tctcatgaga aatctatgct atgtgtccag agcttttgaa acagagtcca ttggagtggg     3900

agttagggag tgtagtggat gccaaatatg tttttcttca gtgcttaaga gaactgtttc     3960

ctgaagtcca gctttgaaca taaacagggg tgtgggttgg gggaggagct taggacaaac     4020

ctctctgatg aaggtcagca atagactgaa gtcttgactg catggaagag gaaaaacatc     4080

agaactgtct gacaatggag gggacagtga gctacgcaca actgccagcg gaggtgaact     4140

tgcacctgcc caggccggat gaacatcagc ctgcaagaac tagttgtttg agttgatttg     4200

cagtgctctc aatgggcaag tgccacattt tccctggcag agatctccaa aaatttaaaa     4260

cagaataata atggctatat cgagtgtttt ctcagtattg gagaaatgct taggtcctat     4320

gatagcttcg ggacatcttt ctgtaatttt cctcaattaa cgggttggta ggggtaaatc     4380

ttatgacacc tttccaccgt cgatttgaga tcagttttaa tggttaaaat gtttactctc     4440

cttctgtcaa ccctcacctt tttatttaca cccctccctt tttttctgta cagggagaga     4500

agacatattg actctgactg gacaccctga ttcctccaaa tatatatacc actgtgtatt     4560

aatctttctc tcagtgtttt ataggagtac taacatttat tgctctgtca ataatgaaag     4620

gctcgatgta atatagctgt aatttacttt ccatatgaat acagtggcta ggttcataaa     4680

agagaattgt gtgagtctgg gattaccaca tctaaaacat tattctttaa tgggataata     4740

caattcattg agcagctacc acttaaaaaa cttgcaggac agttagagcc tgcatttcta     4800

gttaagatgg atcttgtaaa tttaaaattg gattaacatt ggagtgctgg ggtggctgca     4860

ataatttggg ggctaactcc atttggtttc caagatctca cttctgcatt atctttatgg     4920

ctctttaaac cagccaccta gccaatcaag ggcaattccc atctcatcca tcactcaggt     4980

ctttgtaaag ggtgcagcca agctctgcag acttttgcag gattgtctag cctgagtacc     5040

gggctacttc ttaaatgccg tcactcctgc tgagataaat gcgtctttaa aaatagtctc     5100

tgtggcaggt cactggggga caatgtacag cattctggcc atccacttct ttttcacttc     5160

atgttctacc ccaagagact cccgatgtcg gctgtggagg gttaaaggga tgaggctttc     5220

ctttgtttag caaatctgtt cacagttctt gatgatgtat tttatgatgc ccagcttgga     5280

aatagttgct ttccatagtc tcaactgtat tgtgtcatct cctgatgctg atttttgatc     5340

ttttgtttta ttaaaaataa ttagtgaaag aggtgtgcct atctgtgaag tttgtagtac     5400

atcatcctga ggtcatgtaa caagtaaacc ccaacccagc gttccctcct acgttgtgtt     5460

agttcattaa aactaaataa taaaaataac tgtaagaaaa ccttaaggac tggggttaga     5520

gattattttc aggcactaag gtctcttctg tattccaaaa ttgattgaat cagctgggag     5580

aaacattgag aatcgcttcc ttcaactttt attttgcaac atggggacct tgagaggtta     5640

aacgatgtgg cccagattac atgtaatgtg aggagtgggc gagaaggcct aaggtgatgc     5700

tctcatgaca gttctgggga agcctgcagt ttggggaatg ggacaatgtg acaaatactc     5760

gccattccct gagaccattc attgactatt cccttgatgg ctttactata atgagaggaa     5820

gcatcagttt aaacataaaa agattagtat ttatccatcc atttattcat tcagcaaatc     5880

cttattgagc cctgaccatg ggccagtctc tctgccaagc cctggggaca cagtgatgaa     5940

aaaactggcc acagtttctg cttcctgcct cattccactt gcagtgagcg gatattaaat     6000

tggccataaa caccgagtac gatgacctta caatccgcaa actgcacctt tcatgtgtaa     6060

aaggattgct actactttac ttgtcagctg tggatttcca aatgtggtgg ctccctctta     6120

tttttttttc tttgaggagt gtaccaattt tttatcttta taaaccaggt aagggaaatg     6180

atgcccttgc ccattttcta cagacctaat cgatttttac ctaatcagtt ttacagaaag     6240

ggttacatgg aagaagagat aggggccagg aatgcaagag ggacattggt gagtggggta     6300

agaatccccg tagccctggg aaaggtgtct ccacttccac atctggcttt tctagggggc     6360

atctgtgcta actgacctgg gattatgttg gatggcatat gactgcaaat tcaaagaaac     6420

caatttataa taagtttata gtaagttaaa ggtttgtttt actctcatgt gaagggaatc     6480

tggaggaagg aaagccaggg ctggagtggc tgcctttgat catgggagca cactccttct     6540

gcccgatcat tgggagcaca ctccttctgc ctgatcgttg ggagcacact cctgcctgat     6600

catgggcgca cgttccttct gcctgatcgt tgggagcaca ctccttctgc ctgatcatgg     6660

gagcacactc cttctgcctg atcattggga gcacgctcct tctgcctgat cgttgggagc     6720

acactctttc tgcctgatcg ttgggagcac accccttctg cctgatcatt gggagcacac     6780

tccttctgcc tgatcatggg cacacgctcc ttctgcccga tcatgggcac acgctccttc     6840

tgcccgatcg ttgggagcac actccttctg cccaatcatt gggctcacgc tccttctgcc     6900

cgatcgctgg gctcacgctc cttctgcccg atcttgggcg cacgctcctt ctgcccgatc     6960

gttgggcgca cgctccttct gcccgatcgt tgggcgcatg ctccttctgc ccgatcgttg     7020

ggagcacgct cattctgccc gattgttggg agcacgctcc ttctgcccga tcgttgggcg     7080

cacgctcctt ctgcccgatc gttgggcgca cgcttcttct gcctgatcgt tgggcgcacg     7140

ctccttctgc ctgatcgttg ggcgcacgct ccttctgcct gatcgttggg agcacgctcc     7200

ttctgcctga ttgttggaag cacgctcctt ctgccttcag actccttgat ttttagtgca     7260

gtttccatca ctgaggctgc ctcatgggct gagatggctg ttgaagcact gaacctcaca     7320

tccacaattc aggcaggaag cagaaggaag ggcaatgggc aaaggggctg tgccttgcag     7380

ccgatccagc ctccctttgc tgcagaggag gcagggaaat gcggtattta ctgggaacat     7440

tgctgcccct cctccaaatt gagggtcttg gctcgaagga caaaagccag aaaggatagg     7500

tggattagtg cttcttaaac ttttgcgtgc atcagaatca cccagaaaga tgttaaaact     7560

cactcttcaa ggccccatcc ccagagattc ggattctggg gatttggaat ctggggtggg     7620

gtctgaagaa tctgcatttt ttaacaaact cccaggtgac atagatggca tcaattctca     7680

agccatattt tgagtagcac tgacactctt ccaataggtg gtactttgac ttgtcaggga     7740

agttctattg ctctgataac ttaaaaccaa cccaaccaga agctcacaaa aactagcagc     7800

ctgtgaaaaa tgatcaccat tttcctagag ctccgagaca actagtggta gtgcaacagt     7860

aacccaaaaa tgtcaatgaa aatatttcct tccccagaaa ctgcttggtt tcactcaggt     7920

cctgtcctta tgggcctgtg tctggttgca gggcttgaag tatttcggaa gctcagcaga     7980

ggttgaaccc tttcccctgg gggttggtga tctttgtttt ggccatttcc acctggtgaa     8040

gattttcata gacaaatatg cttgtggcat cctgtaattc attgtgcctt atgatggacc     8100

tctgattcta taagcttccc cctagctagg gatgcacggg ggtgatcaag acatgactag     8160

atgtgaacct gacctgcaga cagtccacct gaacgtgcct ggaaatgtct cccgaaaagg     8220

atgaaaagcc tcctccttta gacaaggaag acagagtgga gcaaatttct ctacatagat     8280

ctcattcgaa aacaaattta cagaatgcag aatggctact gtgtgtcttg tgctatgcta     8340

ggtctctctc tctctaagtg gactctgacc ctgtccaaaa cattgtgctt ttgcatgtag     8400

ctgtgtcgca tttaggccca gctctaagaa ccgtttggaa ataaatcaca tagagccttt     8460

gattgtgagg caggcttaaa gtacattttg tttgatttgc agaggcatgg tgaggaattt     8520

atatgcatgg ctgttgtggc agcagcgaga tttccaaaaa gatgaatgat gaaatgaaac     8580

agactgaagc tatctcacaa atgttaaatg gagaaataaa agttgttata gtcattgcta     8640

attacagaat gagcaagaga tttatttagc aggaccatac tatgccccct ggaaggttca     8700

gtttatgagc tggagcacaa ggatttactg tcatttcacc tgaaaacaca catttagctg     8760

tccatttacc tttaatccta caggcttaaa atactttaaa atttcagaga ccattaatat     8820

gtattccttt agaaagcaaa ggtctttcag aagctgtcct ctaccaaagt taatgtggtc     8880

accacatttg atgattttgc taggtaggga ggtttattta atcacagcta ctgtcactca     8940

ggaggatgag ccatttaaaa atggtggccc tgtcctccac ttcttaccta ccatatataa     9000

tctcagtaat tcagatttct ctaaatcagc attagtgatc atttcaatag ggtatgaaca     9060

aaaggcctat aaaaatagct ttccaattcg ccaccaaaaa tgcaaaaatg acaagtaagt     9120

gaggtaacgc atgagctaaa tagcttgatt tagtcactct aaaatgtggg tgtgtatata     9180

tacatacata tatatacaca cacacattat gttatacacc ataaatatat agaagtttta     9240

cttgtcaatt aaaactataa ataaagtggc tttccagaaa aattagatat tggactctat     9300

cacaaaggaa ttgcataaaa atacttacaa acataactat aagcaattga tgagcaaatt     9360

acaaatgact gttttttatt aaaacattcc tccaaaagaa cggcaaagca aatcccatag     9420

acacccaaaa tactaaaagt gacaaaacaa tacttcttta aaaatgtatt ttatgatcta     9480

tttattgata ttctaatggt tttaagaagg ataattttcc aaaacctaaa tgctacacat     9540

tttacagtgg caatatcaac cttatcatga gctaaagatt tgcaatcaga acattggtag     9600

agtgcattgc tgagttataa caagtgtctc aggacgagga tatttggtag gtatccttaa     9660

atatatagat gcttaccagt aggtttaata gaagatttct gaaaggtagc gcaagttttt     9720

atttcattat ttttattttt atttttttga gacagagtct cactctgtca tctaggctgg     9780

agtgcagtgg tgcaatcttg gcttgctgca atctccacct cccaggttca agcgattctc     9840

ccacctcagc ctcccgagta gctgggatta caggcatgcg ccaccatgcc tggctaattt     9900

ttgtattttt agtagagacg gggtttcgcc atgttggcca ggctcgtctc gaactcctgg     9960

cctcaagtga tctgcccgcc tcagcctccc aaagtgctgg gattacaaat gtgagctact    10020

atgcctggtc ccaacttctt aaaattaaat tttggggaag ttcatggaga tatttttgac    10080

atgtaaaagt agaaaacaaa ccatccatag tgtgtgcata tatacacaca aggtttggtt    10140

taatatactt gctgtgcact agtcagtttt gattcaggtt acataaggga taaaatatag    10200

aaagacattt taaagtttga aatatgtgct aagtagttag agatttggca gttttgccac    10260

atttcaaatg ggccaaacat taaaataact tatccatgaa tttcaggttt caaggaagga    10320

ggaatatctg actatttttt tttgtgtgtg agatttggtc tcagcttttt ggtccatctg    10380

aatcctggaa gtccccaact ctaccagacc aaaagggtgt ctctattttt tgttgttact    10440

tctctgttct tgatgtaatg agttaagtag atgaaagaga ttaaggtgca gggaagggct    10500

cttaaaagtt taatgtttca gctttccata gtcattcata cttgtgaatc ttcttcctct    10560

tctacttcaa agtagccaaa acttggaaag ttcaaattaa tctttgggct ccaaagagca    10620

attctgaagg attaacaggt ttcattctct ccagtgggag gtggcctaga caggtgccgg    10680

ttttggggag aggtgagagt acccagatgt gggtgactat ttcctgttct tccctgaaag    10740

tcaggccagt ggtctcgaat cattcccaca gcaactgcta caaaagtgac tatcttaatc    10800

ctttggctag atgggatacc tcttctacct tttcagaggt gagctgttga gtagtaatgt    10860

ccgctacaac accacgctcc cggaatggtg gttcctaaga gcaaagtcag ttaatacaat    10920

ttctccaggt atccagctat ctccaggtgt gcggtcctgt gaagcactct aagaactgta    10980

aaaaatattt cataggtata gaaggcattt gtaatactgt tggttcaaat gtgctgacat    11040

gtagccagtg gaggaagatg tttctttgga agcctgccat ctttctgtaa cgcaccttca    11100

acctgagata attaagagtc attacgtttc ccagtcccat gtcacattga ccagtcctgt    11160

ggtcctatgg ctaagcggag gacacggcca caagctgtga gtcatgaaaa ggagggtgca    11220

ggtgataggc aaagggaccc attagccagt ttacaatgac tggcaactga ccagatagag    11280

cttaccgtat gtccatgtag agttgctcat attagtctgt aaataattct atgcatagtg    11340

aatgcagctt ctgaattatt aaactgatgc tataaatgtg aactgacaaa acccactttt    11400

ggtctctctt catatttttc gtggtttcat ttatctctcc cttcagatgt ttttccatct    11460

gactgtcact ggatagtgga attgctctga ttaccgatgc cttttttgtt ctttggtata    11520

ttaaaatagt agtaacagtt gatctggtga ttggtgaata cagtttaatc tttaatacct    11580

tgtgatccag atatttaaca aacacacatg aaatttactg aatgacaaga actgtgataa    11640

agacttttaa agcctatccc ctttaacctt cataataacc taatgagtaa gtgttatttt    11700

cttcccttta gaagtgggga aactggaaca caggaaagtc acttgtcaaa ggccaaatag    11760

ctacagactg agtattcctt atcccaaatg tttgggacca gaagtgttct ggatttccgg    11820

ttttaaaaga ttttgggata ttggcattat acctaccagc tgagcatccc aagtctgcac    11880

atttgatatc taaaatactc cagtgagctt ttccttggag tacacgttgg cgctcaaaaa    11940

gttttcaatt tgggagcatt tcggattttt gacttttgga tttggatttg gaatgctcaa    12000

cctgttttca gagtcagagc caagttctga atgctcatca cctggcatat agtatggtat    12060

aatcacccca ccaaacctct tccaaaagaa gccagggtca tctgctgcag atgtttctgg    12120

gccactaggc caatattaac caaattatta tagacaccat cttaatgtag aggatcccac    12180

aagactgtga cctaataaaa ccctcatttt ccctatgcat tgtgactaac acagtatttg    12240

atacgtagta ggtctcaata gatgatgaat agaccgatga atgagcacat gagttgaatg    12300

gtgaggagca agtgaagtgt catatgtaaa agagttaatt ctcagattga ttcaaatgcg    12360

gacttaacac tgcagctgta actctgggtc cgggtcttgg tggctcctgc tttgctgagc    12420

tttaaaactt tagtaacctg atgatggaga gatctggggg gtgcagagga gggacctggt    12480

tctggagtgg tgatgctggt tgtcagaggg ctgagggtgg tggccttttg ctaactggta    12540

tggaagcatt tcggtatttt aacaagtatg aaagtagcta tgtgaatttg ccaaatagaa    12600

atcttggagg ccaggtgcag tggttcacac ctgtaatccc agcattttgg g             12651


<210>  22
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Asp Ser Tyr Lys Asp Arg Thr Ser Leu Met Lys Gly Ala Lys 
1               5                   10                  15      


Asp Ile Ala Arg Glu Val Lys Lys Gln Thr Val Lys Lys Val Asn Gln 
            20                  25                  30          


Ala Val Asp Arg Ala Gln Asp Glu Tyr Thr Gln Arg Ser Tyr Ser Arg 
        35                  40                  45              


Phe Gln Asp Glu Glu Asp Asp Asp Asp Tyr Tyr Pro Ala Gly Glu Thr 
    50                  55                  60                  


Tyr Asn Gly Glu Ala Asn Asp Asp Glu Gly Ser Ser Glu Ala Thr Glu 
65                  70                  75                  80  


Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly Glu Tyr Gln Gly Ile 
                85                  90                  95      


Pro Ser Met Asn Gln Ala Lys Asp Ser Ile Val Ser Val Gly Gln Pro 
            100                 105                 110         


Lys Gly Asp Glu Tyr Lys Asp Arg Arg Glu Leu Glu Ser Glu Arg Arg 
        115                 120                 125             


Ala Asp Glu Glu Glu Leu Ala Gln Gln Tyr Glu Leu Ile Ile Gln Glu 
    130                 135                 140                 


Cys Gly His Gly Arg Phe Gln Trp Ala Leu Phe Phe Val Leu Gly Met 
145                 150                 155                 160 


Ala Leu Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu 
                165                 170                 175     


Pro Ser Ala Glu Thr Asp Leu Cys Ile Pro Asn Ser Gly Ser Gly Trp 
            180                 185                 190         


Leu Gly Ser Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Phe Trp 
        195                 200                 205             


Gly Gly Leu Ala Asp Lys Val Gly Arg Lys Gln Ser Leu Leu Ile Cys 
    210                 215                 220                 


Met Ser Val Asn Gly Phe Phe Ala Phe Leu Ser Ser Phe Val Gln Gly 
225                 230                 235                 240 


Tyr Gly Phe Phe Leu Phe Cys Arg Leu Leu Ser Gly Phe Gly Ile Gly 
                245                 250                 255     


Gly Ala Ile Pro Thr Val Phe Ser Tyr Phe Ala Glu Val Leu Ala Arg 
            260                 265                 270         


Glu Lys Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile 
        275                 280                 285             


Gly Gly Ile Tyr Ala Ser Ala Met Ala Trp Ala Ile Ile Pro His Tyr 
    290                 295                 300                 


Gly Trp Ser Phe Ser Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg 
305                 310                 315                 320 


Val Phe Val Ile Val Cys Ala Leu Pro Cys Val Ser Ser Val Val Ala 
                325                 330                 335     


Leu Thr Phe Met Pro Glu Ser Pro Arg Phe Leu Leu Glu Val Gly Lys 
            340                 345                 350         


His Asp Glu Ala Trp Met Ile Leu Lys Leu Ile His Asp Thr Asn Met 
        355                 360                 365             


Arg Ala Arg Gly Gln Pro Glu Lys Val Phe Thr Val Asn Lys Ile Lys 
    370                 375                 380                 


Thr Pro Lys Gln Ile Asp Glu Leu Ile Glu Ile Glu Ser Asp Thr Gly 
385                 390                 395                 400 


Thr Trp Tyr Arg Arg Cys Phe Val Arg Ile Arg Thr Glu Leu Tyr Gly 
                405                 410                 415     


Ile Trp Leu Thr Phe Met Arg Cys Phe Asn Tyr Pro Val Arg Asp Asn 
            420                 425                 430         


Thr Ile Lys Leu Thr Ile Val Trp Phe Thr Leu Ser Phe Gly Tyr Tyr 
        435                 440                 445             


Gly Leu Ser Val Trp Phe Pro Asp Val Ile Lys Pro Leu Gln Ser Asp 
    450                 455                 460                 


Glu Tyr Ala Leu Leu Thr Arg Asn Val Glu Arg Asp Lys Tyr Ala Asn 
465                 470                 475                 480 


Phe Thr Ile Asn Phe Thr Met Glu Asn Gln Ile His Thr Gly Met Glu 
                485                 490                 495     


Tyr Asp Asn Gly Arg Phe Ile Gly Val Lys Phe Lys Ser Val Thr Phe 
            500                 505                 510         


Lys Asp Ser Val Phe Lys Ser Cys Thr Phe Glu Asp Val Thr Ser Val 
        515                 520                 525             


Asn Thr Tyr Phe Lys Asn Cys Thr Phe Ile Asp Thr Val Phe Asp Asn 
    530                 535                 540                 


Thr Asp Phe Glu Pro Tyr Lys Phe Ile Asp Ser Glu Phe Lys Asn Cys 
545                 550                 555                 560 


Ser Phe Phe His Asn Lys Thr Gly Cys Gln Ile Thr Phe Asp Asp Asp 
                565                 570                 575     


Tyr Ser Ala Tyr Trp Ile Tyr Phe Val Asn Phe Leu Gly Thr Leu Ala 
            580                 585                 590         


Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Arg Ile Gly 
        595                 600                 605             


Arg Leu Thr Met Leu Gly Gly Ser Met Val Leu Ser Gly Ile Ser Cys 
    610                 615                 620                 


Phe Phe Leu Trp Phe Gly Thr Ser Glu Ser Met Met Ile Gly Met Leu 
625                 630                 635                 640 


Cys Leu Tyr Asn Gly Leu Thr Ile Ser Ala Trp Asn Ser Leu Asp Val 
                645                 650                 655     


Val Thr Val Glu Leu Tyr Pro Thr Asp Arg Arg Arg Arg Val Leu Pro 
            660                 665                 670         


Cys Cys Pro Gly 
        675     


<210>  23
<211>  3041
<212>  DNA
<213>  Homo sapiens

<400>  23
accactccgc gcgctgcagg cgagagtggc agacggaggc agcccgggga agcgagccgg       60

agcggcgccc gcactgaggc ggctgcagtg ctgacaccac tcagggcaag ggtgtccgac      120

ggctggagcg ttctgttttg aacccaaagt ggatgatgct gtcagagctg aaccactgaa      180

aggaggctgt gaaaatttcc catcttctca ttggccatca gttgagataa gatggaagac      240

tcttacaagg ataggacttc actgatgaag ggtgccaagg acattgccag agaggtgaag      300

aaacaaacag taaagaaggt gaatcaagct gtggaccgag cccaggatga atacacccag      360

aggtcctaca gtcggttcca agatgaagaa gatgatgatg actactaccc ggctggagaa      420

acctataatg gtgaggccaa cgatgacgaa ggctcaagtg aagccactga ggggcatgat      480

gaagatgatg agatctatga gggggagtat cagggcatcc ccagtatgaa ccaagcgaag      540

gacagcatcg tgtcagtggg gcagcccaag ggcgatgagt acaaggaccg gcgggagctg      600

gaatcagaaa ggagagctga cgaggaagag ttagcccagc agtatgagct gataatccaa      660

gaatgcggtc atggtcgttt tcagtgggcc cttttcttcg tcctgggcat ggctcttatg      720

gcagacggtg tagaggtgtt tgtcgttggc ttcgtgttac ccagtgctga gacagacctc      780

tgcatcccaa attcaggatc tggatggcta ggcagcatag tgtacctcgg gatgatggtg      840

ggggcgttct tctggggagg actggcagac aaagtgggaa ggaaacagtc tcttctgatt      900

tgcatgtctg tcaacggatt ctttgccttc ctttcttcat ttgtccaagg ttatggcttc      960

tttctcttct gtcgcttact ttctggattc gggattggag gagccatacc cactgtgttc     1020

tcgtactttg ctgaagtcct ggcccgggaa aagcggggcg aacacttgag ctggctctgc     1080

atgttctgga tgatcggtgg catctacgcc tctgccatgg cctgggccat catcccgcac     1140

tacgggtgga gcttcagcat gggatcggcc taccagtttc acagttggcg tgtgtttgtc     1200

atcgtctgtg cactcccctg tgtctcctcc gtggtggccc tcacattcat gcctgaaagc     1260

ccacgattct tgttggaggt tggaaaacat gatgaagctt ggatgattct gaagttaatt     1320

catgacacca acatgagagc ccggggtcag cctgagaagg tcttcacggt aaacaaaata     1380

aaaactccta aacaaataga tgagctgatt gaaattgaga gtgacacagg aacatggtat     1440

aggaggtgtt ttgttcggat ccgcaccgag ctgtacggaa tttggttgac ttttatgaga     1500

tgtttcaact acccagtcag ggataataca ataaagctta caattgtttg gttcaccctg     1560

tcctttgggt actatggatt atccgtttgg ttccctgatg tcattaaacc tctgcagtcc     1620

gatgaatatg cattgctaac cagaaatgtg gagagagata aatatgcaaa tttcactatt     1680

aactttacaa tggaaaatca gattcatact ggaatggaat acgacaatgg cagattcata     1740

ggggtcaagt tcaaatctgt aactttcaaa gactctgttt ttaagtcctg cacctttgag     1800

gatgtaactt cagtgaacac ctacttcaag aactgcacat ttattgacac tgtttttgac     1860

aacacagatt ttgagccata taaattcatt gacagtgaat ttaaaaactg ctcgtttttt     1920

cacaacaaga cgggatgtca gattaccttt gatgatgact atagtgccta ctggatttat     1980

tttgtcaact ttctggggac attggcagta ttgccaggga acattgtgtc tgctctgctg     2040

atggacagaa ttgggcgctt aacaatgcta ggtggctcta tggtgctttc ggggatcagc     2100

tgtttcttcc tttggttcgg caccagtgaa tccatgatga taggcatgct gtgtctgtac     2160

aatggattga ccatctcagc ctggaactct cttgacgtgg tcactgtgga actgtacccc     2220

acagaccgga gacgcagagt cttgccatgt tgccccggct gatcttgaac tcctggcctc     2280

aagcaatcct cctgcctcag cctcccaaag ttctgggatt acagtctcga gccactgcac     2340

ctggctttct ttccattttt gaggattaaa attacttgaa attttccaaa tatattatac     2400

aaggtcttgc taagaactta gtagatttct ttattgttgt cttttttctc tctcttttgc     2460

cttgtagaaa tatcccacaa agtgaagtaa ccaagtcaac aagtgtgaac aattttatag     2520

ctctccttaa atttactata cagctctcag aaacaacgga gccagtttat agcaggagcc     2580

attagtgggt gtggacctct tttctaagat ctgcttctaa acttggcttt atcacataaa     2640

gagagaaaag cattacaaac aatttgaagg aattctttgt cttataaaaa aaattctgaa     2700

aacctccttg tattcccact aggaggtata gttaaccttg caactccaca aacagaccac     2760

tttacacact tgcccagggg cctttgtttt tgcttgcccc tcctctgaaa tgctctctac     2820

aggtgattaa gtggcttttc cctttactta ggtgtctact caggtaaaat cttaaccaag     2880

acgcctttac ttaaaatgtc cctctgcccc accctgaggc ttttaacttg catagccctc     2940

atcatcacct gacataatat gtacttcttt gcttttatag atattatctg tgtccctcca     3000

ctaggatgtc catttcatgg gaataaagac tttgtctctt t                         3041


