                         SEQUENCE LISTING 
 
<110>  PHARMTEKX CO., LTD. AND HWEI-JIUNG WANG 
<120>  TUMOR NECROSIS FACTOR ALPHA RECOMBINANT ANTIBODY 
<130>  PI-110-013-US 
<160>  20     
<170>  PatentIn version 3.5 

<210>  1 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>  
<223>   

<400>  1 

Glu Val Arg Leu Val Glu Ser Gly Gly Thr Leu Val Lys Pro Gly Gly  
1               5                   10                  15       
Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ser Met Asp Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val  
        35                  40                  45               
Ala Gly Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ser Gln Thr Val  
    50                  55                  60                   
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr  
65                  70                  75                  80   
Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His  
        195                 200                 205              
Pro Pro Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn  
    210                 215                 220                  
Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu  
225                 230                 235                 240  
Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp  
                245                 250                 255      
Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp  
            260                 265                 270          
Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly  
        275                 280                 285              
Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn  
    290                 295                 300                  
Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp  
305                 310                 315                 320  
Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro  
                325                 330                 335      
Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln  
            340                 345                 350          
Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn  
        355                 360                 365              
Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile  
    370                 375                 380                  
Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr  
385                 390                 395                 400  
Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr  
                405                 410                 415      
Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe  
            420                 425                 430          
Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu  
        435                 440                 445              
Ser Leu Ser His Ser Pro Gly Lys 
     450                 455      

<210>  2 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222> 
<223>  

<400>  2 

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
1               5                   10                  15       
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ser Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
Gly Gly Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Asn Ser Ala Leu  
    50                  55                  60                   
Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe  
65                  70                  75                  80   
Leu Gln Met His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His  
        195                 200                 205              
Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg  
    210                 215                 220                  
Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro  
225                 230                 235                 240  
Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr  
                245                 250                 255      
Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp  
            260                 265                 270          
Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr  
        275                 280                 285              
Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val  
    290                 295                 300                  
Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu  
305                 310                 315                 320  
Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg  
                325                 330                 335      
Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val  
            340                 345                 350          
Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile  
        355                 360                 365              
Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp  
    370                 375                 380                  
Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro  
385                 390                 395                 400  
Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser  
                405                 410                 415      
Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val  
            420                 425                 430          
Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His  
        435                 440                 445              
Ser Pro Gly Lys  
    450          

<210>  3 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>  
<223>

<400>  3 

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg  
1               5                   10                  15       
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val  
    50                  55                  60                   
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr  
65                  70                  75                  80   
Leu Asp Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His  
        195                 200                 205              
Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg  
    210                 215                 220                  
Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro  
225                 230                 235                 240  
Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr  
                245                 250                 255      
Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp  
            260                 265                 270          
Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr  
        275                 280                 285              
Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val  
    290                 295                 300                  
Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu  
305                 310                 315                 320  
Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg  
                325                 330                 335      
Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val  
            340                 345                 350          
Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile  
        355                 360                 365              
Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp  
    370                 375                 380                  
Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro  
385                 390                 395                 400  
Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser  
                405                 410                 415      
Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val  
            420                 425                 430          
Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His  
        435                 440                 445              
Ser Pro Gly Lys  
    450          

<210>  4 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>  
<223>  

<400>  4 

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
1               5                   10                  15       
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val  
    50                  55                  60                   
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr  
65                  70                  75                  80   
Leu Gln Met His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His  
        195                 200                 205              
Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg  
    210                 215                 220                  
Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro  
225                 230                 235                 240  
Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr  
                245                 250                 255      
Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp  
            260                 265                 270          
Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr  
        275                 280                 285              
Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val  
    290                 295                 300                  
Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu  
305                 310                 315                 320  
Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg  
                325                 330                 335      
Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val  
            340                 345                 350          
Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile  
        355                 360                 365              
Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp  
    370                 375                 380                  
Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro  
385                 390                 395                 400  
Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser  
                405                 410                 415      
Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val  
            420                 425                 430          
Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His  
        435                 440                 445              
Ser Pro Gly Lys  
    450          

<210>  5 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>   

<400>  5 

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
1               5                   10                  15       
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
Gly Gly Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val  
    50                  55                  60                   
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr  
65                  70                  75                  80   
Leu Gln Met His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His  
        195                 200                 205              
Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg  
    210                 215                 220                  
Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro  
225                 230                 235                 240  
Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr  
                245                 250                 255      
Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp  
            260                 265                 270          
Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr  
        275                 280                 285              
Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val  
    290                 295                 300                  
Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu  
305                 310                 315                 320  
Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg  
                325                 330                 335      
Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val  
            340                 345                 350          
Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile  
        355                 360                 365              
Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp  
    370                 375                 380                  
Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro  
385                 390                 395                 400  
Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser  
                405                 410                 415      
Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val  
            420                 425                 430          
Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His  
        435                 440                 445              
Ser Pro Gly Lys  
    450          

<210>  6 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>  

<400>  6 

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
1               5                   10                  15       
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
Gly Gly Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val  
    50                  55                  60                   
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe  
65                  70                  75                  80   
Leu Gln Met His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His  
        195                 200                 205              
Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg  
    210                 215                 220                  
Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro  
225                 230                 235                 240  
Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr  
                245                 250                 255      
Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp  
            260                 265                 270          
Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr  
        275                 280                 285              
Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val  
    290                 295                 300                  
Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu  
305                 310                 315                 320  
Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg  
                325                 330                 335      
Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val  
            340                 345                 350          
Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile  
        355                 360                 365              
Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp  
    370                 375                 380                  
Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro  
385                 390                 395                 400  
Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser  
                405                 410                 415      
Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val  
            420                 425                 430          
Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His  
        435                 440                 445              
Ser Pro Gly Lys  
    450          

<210>  7 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>   

<400>  7 

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
1               5                   10                  15       
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
Gly Gly Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val  
    50                  55                  60                   
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe  
65                  70                  75                  80   
Leu Gln Met His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His  
        195                 200                 205              
Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg  
    210                 215                 220                  
Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro  
225                 230                 235                 240  
Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr  
                245                 250                 255      
Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp  
            260                 265                 270          
Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr  
        275                 280                 285              
Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val  
    290                 295                 300                  
Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu  
305                 310                 315                 320  
Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg  
                325                 330                 335      
Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val  
            340                 345                 350          
Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile  
        355                 360                 365              
Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp  
    370                 375                 380                  
Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro  
385                 390                 395                 400  
Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser  
                405                 410                 415      
Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val  
            420                 425                 430          
Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His  
        435                 440                 445              
Ser Pro Gly Lys  
    450          

<210>  8 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>

<400>  8 

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
1               5                   10                  15       
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
Gly Gly Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ala Leu  
    50                  55                  60                   
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe  
65                  70                  75                  80   
Leu Gln Met His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His  
        195                 200                 205              
Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg  
    210                 215                 220                  
Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro  
225                 230                 235                 240  
Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr  
                245                 250                 255      
Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp  
            260                 265                 270          
Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr  
        275                 280                 285              
Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val  
    290                 295                 300                  
Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu  
305                 310                 315                 320  
Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg  
                325                 330                 335      
Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val  
            340                 345                 350          
Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile  
        355                 360                 365              
Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp  
    370                 375                 380                  
Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro  
385                 390                 395                 400  
Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser  
                405                 410                 415      
Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val  
            420                 425                 430          
Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His  
        435                 440                 445              
Ser Pro Gly Lys  
    450          

<210>  9 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>  
<223>   

<400>  9 

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
1               5                   10                  15       
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
Gly Gly Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ala Leu  
    50                  55                  60                   
Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe  
65                  70                  75                  80   
Leu Gln Met His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His  
        195                 200                 205              
Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg  
    210                 215                 220                  
Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro  
225                 230                 235                 240  
Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr  
                245                 250                 255      
Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp  
            260                 265                 270          
Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr  
        275                 280                 285              
Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val  
    290                 295                 300                  
Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu  
305                 310                 315                 320  
Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg  
                325                 330                 335      
Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val  
            340                 345                 350          
Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile  
        355                 360                 365              
Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp  
    370                 375                 380                  
Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro  
385                 390                 395                 400  
Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser  
                405                 410                 415      
Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val  
            420                 425                 430          
Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His  
        435                 440                 445              
Ser Pro Gly Lys  
    450          

<210>  10 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>   

<400>  10 

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
1               5                   10                  15       
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr  
            20                  25                  30           
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
Gly Gly Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Asn Ser Ala Leu  
    50                  55                  60                   
Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe  
65                  70                  75                  80   
Leu Gln Met His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly  
            100                 105                 110          
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser  
        115                 120                 125              
Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val  
    130                 135                 140                  
Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser  
                165                 170                 175      
Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val  
            180                 185                 190          
Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His  
        195                 200                 205              
Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg  
    210                 215                 220                  
Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro  
225                 230                 235                 240  
Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr  
                245                 250                 255      
Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp  
            260                 265                 270          
Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr  
        275                 280                 285              
Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val  
    290                 295                 300                  
Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu  
305                 310                 315                 320  
Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg  
                325                 330                 335      
Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val  
            340                 345                 350          
Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile  
        355                 360                 365              
Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp  
    370                 375                 380                  
Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro  
385                 390                 395                 400  
Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser  
                405                 410                 415      
Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val  
            420                 425                 430          
Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His  
        435                 440                 445              
Ser Pro Gly Lys      450          

<210>  11 
<211>  218 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>  

<400>  11 

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly  
1               5                   10                  15       
Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu His Trp Tyr Arg Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala  
65                  70                  75                  80   
Asp Asp Ala Gly Val Tyr Tyr Cys Gln His Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr  
            180                 185                 190          
Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser  
        195                 200                 205              
Phe Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215              

<210>  12 
<211>  217 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>  
<223>  

<400>  12 

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Gly  
1               5                   10                  15       
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro  
65                  70                  75                  80   
Glu Asp Val Ala Val Tyr Tyr Cys Gln His Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Asn Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser  
                165                 170                 175      
Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser  
            180                 185                 190          
Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe  
        195                 200                 205              
Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215          

<210>  13 
<211>  217 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>  

<400>  13 

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser  
                165                 170                 175      
Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser  
            180                 185                 190          
Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe  
        195                 200                 205              
Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215          

<210>  14 
<211>  217 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>  

<400>  14 

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro  
65                  70                  75                  80   
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Thr Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser  
                165                 170                 175      
Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser  
            180                 185                 190          
Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe  
        195                 200                 205              
Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215          

<210>  15 
<211>  217 
<212>  PRT 
<213>  Artificial Sequence  

<220> 
<221>   
<222>   
<223>

<400>  15 

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro  
65                  70                  75                  80   
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Thr Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser  
                165                 170                 175      
Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser  
            180                 185                 190          
Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe  
        195                 200                 205              
Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215          

<210>  16 
<211>  217 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>

<400>  16 

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro  
65                  70                  75                  80   
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Thr Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser  
                165                 170                 175      
Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser  
            180                 185                 190          
Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe  
        195                 200                 205              
Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215          

<210>  17 
<211>  217 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>   
<223>

<400>  17 

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro  
65                  70                  75                  80   
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Thr Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser  
                165                 170                 175      
Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser  
            180                 185                 190          
Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe  
        195                 200                 205              
Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215          

<210>  18 
<211>  217 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>  
<223>  

<400>  18 

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro  
65                  70                  75                  80   
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Thr Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser  
                165                 170                 175      
Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser  
            180                 185                 190          
Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe  
        195                 200                 205              
Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215          

<210>  19 
<211>  217 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>  
<223>  

<400>  19 

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro  
65                  70                  75                  80   
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Asn Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser  
                165                 170                 175      
Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser  
            180                 185                 190          
Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe  
        195                 200                 205              
Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215          

<210>  20 
<211>  217 
<212>  PRT 
<213>  Artificial Sequence 

<220> 
<221>   
<222>  
<223>  

<400>  20 

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr  
            20                  25                  30           
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro  
65                  70                  75                  80   
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr  
                85                  90                  95       
Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Thr Asp Ala Gln  
            100                 105                 110          
Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly  
        115                 120                 125              
Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile  
    130                 135                 140                  
Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln  
145                 150                 155                 160  
Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser  
                165                 170                 175      
Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser  
            180                 185                 190          
Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe  
        195                 200                 205              
Gln Arg Ser Glu Cys Gln Arg Val Asp  
    210                 215          
