<110>    CJ CheilJedang Corporation

<120>    Novel protein variant and a method for producing L-lysine using
         the same

<130>    OPP20212421KR 

<150>    KR 10-2021-0013694
<151>    2021-01-29

<150>    KR 10-2021-0013691
<151>    2021-01-29

<150>    KR 10-2021-0013693
<151>    2021-01-29

<150>    KR 10-2021-0013690
<151>    2021-01-29

<150>    PCT/KR2021/003261
<151>    2021-03-16

<160>    173

<170>    koPatentIn 3.0

<210>    1
<211>    433
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (F220C)_integral membrane transport protein


<400>    1
Met Thr Thr Ala Val Asp Gln Asn Ser Pro Pro Lys Gln Gln Leu Asn
  1               5                  10                  15 

Lys Arg Val Leu Leu Gly Ser Leu Ser Gly Ser Val Ile Glu Trp Phe
             20                  25                  30 

Asp Phe Leu Val Tyr Gly Thr Val Ala Ala Leu Val Phe Asn Lys Met
         35                  40                  45 

Tyr Phe Pro Ser Gly Asn Glu Phe Leu Ser Thr Ile Leu Ala Tyr Ala
     50                  55                  60 

Ser Phe Ser Leu Thr Phe Phe Phe Arg Pro Ile Gly Gly Val Ile Phe
 65                  70                  75                  80 

Ala His Ile Gly Asp Arg Ile Gly Arg Lys Lys Thr Leu Phe Ile Thr
                 85                  90                  95 

Leu Met Leu Met Gly Gly Gly Thr Val Ala Ile Gly Leu Leu Pro Asp
            100                 105                 110 

Tyr Asn Ala Ile Gly Ile Trp Ala Pro Ile Leu Leu Met Phe Leu Arg
        115                 120                 125 

Ile Leu Gln Gly Ile Gly Ile Gly Gly Glu Trp Gly Gly Ala Leu Leu
    130                 135                 140 

Leu Ala Tyr Glu Tyr Ala Pro Lys Lys Gln Arg Gly Leu Tyr Gly Ala
145                 150                 155                 160 

Val Pro Gln Met Gly Ile Ser Leu Gly Met Leu Leu Ala Ala Gly Val
                165                 170                 175 

Ile Ser Leu Leu Thr Leu Met Pro Glu Asp Gln Phe Leu Thr Trp Gly
            180                 185                 190 

Trp Arg Ile Pro Phe Val Gly Ser Ile Leu Leu Val Phe Ile Gly Leu
        195                 200                 205 

Phe Ile Arg Asn Gly Leu Asp Glu Thr Pro Glu Cys Lys Arg Ile Arg
    210                 215                 220 

Asp Ser Gly Gln Gln Val Lys Met Pro Leu Lys Glu Val Leu Thr Lys
225                 230                 235                 240 

Tyr Trp Pro Ala Val Leu Val Ser Ile Gly Ala Lys Ala Ala Glu Thr
                245                 250                 255 

Gly Pro Phe Tyr Ile Phe Gly Thr Tyr Ile Val Ala Tyr Ala Thr Asn
            260                 265                 270 

Phe Leu Asn Ile Arg Asp Asn Ile Val Leu Leu Ala Val Ala Cys Ala
        275                 280                 285 

Ala Leu Val Ala Thr Ile Trp Met Pro Leu Phe Gly Ser Phe Ser Asp
    290                 295                 300 

Arg Val Asn Arg Ala Val Leu Tyr Arg Ile Cys Ala Ser Ala Thr Ile
305                 310                 315                 320 

Val Leu Ile Val Pro Tyr Tyr Leu Val Leu Asn Thr Gly Glu Ile Trp
                325                 330                 335 

Ala Leu Phe Ile Thr Thr Val Ile Gly Phe Gly Ile Leu Trp Gly Ser
            340                 345                 350 

Val Asn Ala Ile Leu Gly Thr Val Ile Ala Glu Asn Phe Ala Pro Glu
        355                 360                 365 

Val Arg Tyr Thr Gly Ala Thr Leu Gly Tyr Gln Val Gly Ala Ala Leu
    370                 375                 380 

Phe Gly Gly Thr Ala Pro Ile Ile Ala Ala Trp Leu Phe Glu Ile Ser
385                 390                 395                 400 

Gly Gly Gln Trp Trp Pro Ile Ala Val Tyr Val Ala Ala Cys Cys Leu
                405                 410                 415 

Leu Ser Val Ile Ala Ser Phe Phe Ile Gln Arg Val Ala His Gln Glu
            420                 425                 430 

Asn
   


<210>    2
<211>    1302
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (F220C)_NCgl2816


<400>    2
atgacaaccg cagtagatca aaactcaccg cccaagcagc aactcaacaa gcgcgtcctg         60

ctgggcagct tgagtggcag cgttatcgaa tggttcgact tcctggttta cggaaccgtc        120

gccgcgctgg tcttcaacaa gatgtacttc cccagcggca acgagttcct ctccacaatc        180

ctggcgtacg catccttctc cctgaccttc ttcttccgcc ccattggtgg cgtcatcttc        240

gcccacatcg gcgaccgcat tgggcgtaag aagaccctgt tcatcacctt gatgctcatg        300

ggtggcggca ccgtcgccat tggtttgctg cccgactaca acgccatcgg catttgggca        360

ccaatccttc tgatgttcct ccgcattttg cagggcatcg gaattggcgg cgaatggggt        420

ggcgcactgc tcctggcata cgaatacgct ccaaagaagc agcgtgggct ctacggcgca        480

gttcctcaaa tgggcatttc cctgggcatg ctgcttgcag ctggcgtgat ctctctgctc        540

accctcatgc cggaagatca gttcctcacc tggggctggc gcatcccatt cgtcggatcc        600

atcctcctag tgttcatcgg cctgttcatc cgaaacggcc ttgatgaaac ccccgagtgc        660

aagcgtatcc gcgattccgg ccagcaggta aagatgcctc tgaaggaagt tctgaccaag        720

tactggccag ccgttctggt ctccatcggc gcaaaagctg ccgagaccgg ccccttctac        780

atcttcggca cctacatcgt tgcttacgca accaacttcc tgaacatccg cgacaacatt        840

gtccttctgg cagttgcttg cgccgccctc gttgccacca tctggatgcc actgttcgga        900

tccttctccg accgcgtcaa ccgtgcagtg ctctacagga tctgtgcatc cgcaaccatc        960

gtgctgattg tcccttacta cttggtcctc aacaccggcg aaatttgggc actgtttatc       1020

actaccgtga ttggcttcgg catcctctgg ggtagcgtca acgcaatcct cggaaccgtc       1080

atcgcagaaa acttcgcacc tgaggtccgc tacaccggcg ctaccctggg ttaccaagtc       1140

ggagcagcac tcttcggcgg taccgcaccc attatcgcag catggctgtt cgaaatctcc       1200

ggcggacaat ggtggccaat cgccgtctac gtcgctgcat gttgccttct ctctgtgatc       1260

gcctcgttct tcatccaacg cgtcgcgcac caagagaact aa                          1302


<210>    3
<211>    433
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_integral membrane transport protein


<400>    3
Met Thr Thr Ala Val Asp Gln Asn Ser Pro Pro Lys Gln Gln Leu Asn
  1               5                  10                  15 

Lys Arg Val Leu Leu Gly Ser Leu Ser Gly Ser Val Ile Glu Trp Phe
             20                  25                  30 

Asp Phe Leu Val Tyr Gly Thr Val Ala Ala Leu Val Phe Asn Lys Met
         35                  40                  45 

Tyr Phe Pro Ser Gly Asn Glu Phe Leu Ser Thr Ile Leu Ala Tyr Ala
     50                  55                  60 

Ser Phe Ser Leu Thr Phe Phe Phe Arg Pro Ile Gly Gly Val Ile Phe
 65                  70                  75                  80 

Ala His Ile Gly Asp Arg Ile Gly Arg Lys Lys Thr Leu Phe Ile Thr
                 85                  90                  95 

Leu Met Leu Met Gly Gly Gly Thr Val Ala Ile Gly Leu Leu Pro Asp
            100                 105                 110 

Tyr Asn Ala Ile Gly Ile Trp Ala Pro Ile Leu Leu Met Phe Leu Arg
        115                 120                 125 

Ile Leu Gln Gly Ile Gly Ile Gly Gly Glu Trp Gly Gly Ala Leu Leu
    130                 135                 140 

Leu Ala Tyr Glu Tyr Ala Pro Lys Lys Gln Arg Gly Leu Tyr Gly Ala
145                 150                 155                 160 

Val Pro Gln Met Gly Ile Ser Leu Gly Met Leu Leu Ala Ala Gly Val
                165                 170                 175 

Ile Ser Leu Leu Thr Leu Met Pro Glu Asp Gln Phe Leu Thr Trp Gly
            180                 185                 190 

Trp Arg Ile Pro Phe Val Gly Ser Ile Leu Leu Val Phe Ile Gly Leu
        195                 200                 205 

Phe Ile Arg Asn Gly Leu Asp Glu Thr Pro Glu Phe Lys Arg Ile Arg
    210                 215                 220 

Asp Ser Gly Gln Gln Val Lys Met Pro Leu Lys Glu Val Leu Thr Lys
225                 230                 235                 240 

Tyr Trp Pro Ala Val Leu Val Ser Ile Gly Ala Lys Ala Ala Glu Thr
                245                 250                 255 

Gly Pro Phe Tyr Ile Phe Gly Thr Tyr Ile Val Ala Tyr Ala Thr Asn
            260                 265                 270 

Phe Leu Asn Ile Arg Asp Asn Ile Val Leu Leu Ala Val Ala Cys Ala
        275                 280                 285 

Ala Leu Val Ala Thr Ile Trp Met Pro Leu Phe Gly Ser Phe Ser Asp
    290                 295                 300 

Arg Val Asn Arg Ala Val Leu Tyr Arg Ile Cys Ala Ser Ala Thr Ile
305                 310                 315                 320 

Val Leu Ile Val Pro Tyr Tyr Leu Val Leu Asn Thr Gly Glu Ile Trp
                325                 330                 335 

Ala Leu Phe Ile Thr Thr Val Ile Gly Phe Gly Ile Leu Trp Gly Ser
            340                 345                 350 

Val Asn Ala Ile Leu Gly Thr Val Ile Ala Glu Asn Phe Ala Pro Glu
        355                 360                 365 

Val Arg Tyr Thr Gly Ala Thr Leu Gly Tyr Gln Val Gly Ala Ala Leu
    370                 375                 380 

Phe Gly Gly Thr Ala Pro Ile Ile Ala Ala Trp Leu Phe Glu Ile Ser
385                 390                 395                 400 

Gly Gly Gln Trp Trp Pro Ile Ala Val Tyr Val Ala Ala Cys Cys Leu
                405                 410                 415 

Leu Ser Val Ile Ala Ser Phe Phe Ile Gln Arg Val Ala His Gln Glu
            420                 425                 430 

Asn
   


<210>    4
<211>    1302
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl2816


<400>    4
atgacaaccg cagtagatca aaactcaccg cccaagcagc aactcaacaa gcgcgtcctg         60

ctgggcagct tgagtggcag cgttatcgaa tggttcgact tcctggttta cggaaccgtc        120

gccgcgctgg tcttcaacaa gatgtacttc cccagcggca acgagttcct ctccacaatc        180

ctggcgtacg catccttctc cctgaccttc ttcttccgcc ccattggtgg cgtcatcttc        240

gcccacatcg gcgaccgcat tgggcgtaag aagaccctgt tcatcacctt gatgctcatg        300

ggtggcggca ccgtcgccat tggtttgctg cccgactaca acgccatcgg catttgggca        360

ccaatccttc tgatgttcct ccgcattttg cagggcatcg gaattggcgg cgaatggggt        420

ggcgcactgc tcctggcata cgaatacgct ccaaagaagc agcgtgggct ctacggcgca        480

gttcctcaaa tgggcatttc cctgggcatg ctgcttgcag ctggcgtgat ctctctgctc        540

accctcatgc cggaagatca gttcctcacc tggggctggc gcatcccatt cgtcggatcc        600

atcctcctag tgttcatcgg cctgttcatc cgaaacggcc ttgatgaaac ccccgagttc        660

aagcgtatcc gcgattccgg ccagcaggta aagatgcctc tgaaggaagt tctgaccaag        720

tactggccag ccgttctggt ctccatcggc gcaaaagctg ccgagaccgg ccccttctac        780

atcttcggca cctacatcgt tgcttacgca accaacttcc tgaacatccg cgacaacatt        840

gtccttctgg cagttgcttg cgccgccctc gttgccacca tctggatgcc actgttcgga        900

tccttctccg accgcgtcaa ccgtgcagtg ctctacagga tctgtgcatc cgcaaccatc        960

gtgctgattg tcccttacta cttggtcctc aacaccggcg aaatttgggc actgtttatc       1020

actaccgtga ttggcttcgg catcctctgg ggtagcgtca acgcaatcct cggaaccgtc       1080

atcgcagaaa acttcgcacc tgaggtccgc tacaccggcg ctaccctggg ttaccaagtc       1140

ggagcagcac tcttcggcgg taccgcaccc attatcgcag catggctgtt cgaaatctcc       1200

ggcggacaat ggtggccaat cgccgtctac gtcgctgcat gttgccttct ctctgtgatc       1260

gcctcgttct tcatccaacg cgtcgcgcac caagagaact aa                          1302


<210>    5
<211>    775
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (P43L)_DNA polymerase III subunits gamma and tau


<400>    5
Met Ala Leu Tyr Ser Lys Tyr Arg Pro Ala Ser Phe Gly Glu Leu Val
  1               5                  10                  15 

Gly Gln Ser Gln Val Thr Asp Pro Leu Ser Ala Ala Leu Asp Ser Gly
             20                  25                  30 

Arg Ile Asn His Ala Tyr Leu Phe Ser Gly Leu Arg Gly Cys Gly Lys
         35                  40                  45 

Thr Ser Ser Ala Arg Ile Leu Ala Arg Ser Leu Asn Cys Val Glu Gly
     50                  55                  60 

Pro Thr Ser Thr Pro Cys Gly Val Cys Asn Ser Cys Val Ala Leu Ala
 65                  70                  75                  80 

Pro Gly Gly Pro Gly Thr Leu Asp Val Thr Glu Leu Asp Ala Ala Ser
                 85                  90                  95 

Asn Asn Gly Val Asp Asp Met Arg Glu Leu Arg Glu Arg Ala Asn Tyr
            100                 105                 110 

Ala Pro Ala Glu Ser Arg Tyr Arg Val Phe Ile Ile Asp Glu Ala His
        115                 120                 125 

Met Ile Ser Thr Gln Gly Phe Asn Ala Leu Leu Lys Ile Val Glu Glu
    130                 135                 140 

Pro Pro Ala His Leu Ile Phe Ile Phe Ala Thr Thr Glu Pro Asp Lys
145                 150                 155                 160 

Met Ile Gly Thr Ile Arg Ser Arg Thr His Asn Tyr Pro Phe Arg Leu
                165                 170                 175 

Leu Thr Pro Gly Asp Met Arg Lys Val Leu Lys Asn Ala Val Asp Gly
            180                 185                 190 

Glu Gly Val His Val Asp Asp Ser Val Tyr Pro Leu Val Ile Arg Ala
        195                 200                 205 

Gly Gly Gly Ser Pro Arg Asp Ser Leu Ser Ile Leu Asp Gln Leu Ile
    210                 215                 220 

Ala Gly Ser Gly Pro Glu Gly Leu Thr Tyr Glu Arg Ala Leu Pro Leu
225                 230                 235                 240 

Leu Gly Val Thr Ser Phe Thr Leu Ile Asp Asp Ser Ile His Ala Leu
                245                 250                 255 

Ala Ser Lys Asp Asn Ala Ser Met Phe Thr Thr Ile Asp Asn Val Ile
            260                 265                 270 

Glu Glu Gly Leu Glu Pro Arg Arg Phe Thr Ile Asp Leu Leu Asp Arg
        275                 280                 285 

Leu Arg Asp Leu Met Val Leu Gln Ala Val Pro Glu Ala Leu Asn Leu
    290                 295                 300 

Gly Leu Val Asp Ala Pro Thr Asp Arg Ala Asp Ala Leu Ile Glu Gln
305                 310                 315                 320 

Ser Thr Leu Phe Lys Gly Asn Glu Leu Ala Asn Leu Ala Ser Met Val
                325                 330                 335 

Asn Ser Gly Leu Asp Asp Met Arg Gly Ala Thr Ser Pro Arg Leu Leu
            340                 345                 350 

Leu Glu Ile Leu Cys Ala Arg Leu Leu Leu Ala Ser Asn Thr Val Ala
        355                 360                 365 

Gly Pro Ala Val Ser Ser Ser Thr Asp Ala Ala Pro Ala Ala Thr Pro
    370                 375                 380 

Gly Gly Leu Thr Gly Ile Ala Ala Ala Arg Ala Lys Ala Arg Glu Tyr
385                 390                 395                 400 

Gly Gln Lys Lys Ala Ala Pro Ala Pro Ala Pro Thr Pro Ala Pro Glu
                405                 410                 415 

Pro Val Arg Glu Gln Ser Leu Ala Pro Thr Pro Glu Pro Thr Pro Ala
            420                 425                 430 

Ala Glu Pro Thr Ser Gln Pro Ala Pro Glu Pro Glu Pro Ala Arg Glu
        435                 440                 445 

Pro Val Val Glu Val Arg Glu Ala Ser Val Glu Lys Gln Pro Ala Ser
    450                 455                 460 

Ser Asp Pro Leu Glu Thr Ile Arg Ser Arg Trp Ser Glu Leu Arg Asn
465                 470                 475                 480 

Ile Val Glu Lys Gln Ser Val Arg Thr Ser Ile Met Leu Thr Glu Ala
                485                 490                 495 

Arg Val Leu Gly Leu Arg Gly Asp Thr Leu Val Leu Gly His Ser Thr
            500                 505                 510 

Gly Ala Leu Ala Ala Arg Leu Asn Ala Ala Asp His Asn Gly Ile Leu
        515                 520                 525 

Val Lys Val Leu Ala Glu Glu Thr Gly Leu Gln Leu Lys Val Glu Cys
    530                 535                 540 

Ile Val Gly Thr Asn Pro Ala Glu Ala Gly Phe Thr Ala Gln Pro Ala
545                 550                 555                 560 

Val Gln Lys Ser Thr Trp Asn Pro Asn Tyr Asp Ser Lys Pro Ala Thr
                565                 570                 575 

Pro Ser Ala Pro Ala Gln Pro Gln Thr Pro Lys Gln Glu Ser Val Pro
            580                 585                 590 

Thr Glu Pro Glu Glu Pro Glu Ser Ser Ala Glu Thr Ser Gly Trp Gly
        595                 600                 605 

Gln Pro Val Lys Ile Gly Gly Pro Ala Pro Glu Ala Gln Thr Pro Thr
    610                 615                 620 

Pro Pro Pro Ala Pro Val Val Pro Ala Thr Pro Ala Ala Pro Ala Ala
625                 630                 635                 640 

Gly Ala Ala Lys Pro Ala Trp Lys Glu Arg Val Glu Gln Ala Ala Ala
                645                 650                 655 

Asn Ala Ala Gln Gln Arg Gln His Arg Gln Gly Ser Ser Glu Pro Phe
            660                 665                 670 

Glu Arg Gly Val Pro Leu Pro Pro Glu Pro Asp Leu Pro Pro Asp Pro
        675                 680                 685 

Tyr Gly Tyr Pro Ala Asp Glu Gly Phe Pro Glu Arg Asn Gln Gly Phe
    690                 695                 700 

Gln Gln Gln Pro Ala Pro Pro Val Glu Gln Pro Ala Pro Glu Pro Ala
705                 710                 715                 720 

Thr Glu Pro Val Pro Ala Val Ala Pro Glu Pro Glu Val Ser Gln Leu
                725                 730                 735 

Ser Glu Glu Glu Gln Leu Ile Arg Glu Ala Asp Glu Glu Pro Gly Glu
            740                 745                 750 

Met Asp Arg Arg Asp Ala Lys Thr Ile Ala Met Glu Leu Leu Ala Gln
        755                 760                 765 

Glu Leu Gly Ala Lys Pro Leu
    770                 775


<210>    6
<211>    2328
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (P43L)_dnaZX


<400>    6
gtggctttgt atagcaagta tcgaccggca agttttggtg aactagttgg gcagtcgcaa         60

gtgactgacc ctctgtccgc agctttggat agcgggcgca tcaaccatgc gtaccttttt        120

tcgggtctgc gtggttgtgg caagacgtcg tcggcacgca tccttgcccg gtccctcaac        180

tgcgtggaag gcccaacttc cacgccgtgt ggggtgtgta attcttgcgt agcgctggcc        240

ccgggtggcc ctggaaccct tgatgtaaca gagctcgacg ccgcgagtaa caatggtgtc        300

gatgacatgc gtgaactgcg cgaacgcgcg aactacgccc cggcggaatc tcgctaccgc        360

gtgttcatca ttgacgaagc ccacatgatc agtacccaag gcttcaacgc cttgctgaaa        420

atcgttgaag agccaccagc gcacctgatt ttcatcttcg ccaccaccga gccggacaaa        480

atgatcggta cgatccgttc ccgcacgcac aattacccat tccgcctgct caccccaggg        540

gatatgcgca aagtgctgaa aaatgcggtc gatggcgaag gcgtccacgt cgacgattcc        600

gtttacccac tggtcatccg cgccggcggc ggcagccccc gcgacagcct ctccatcctc        660

gaccagctca tcgccggctc gggcccggag ggcttgacat atgagcgcgc cttgccgctg        720

ctcggtgtca caagcttcac gcttatcgac gattcgatcc atgcccttgc atctaaagac        780

aacgcaagca tgttcaccac gatcgataac gtcatcgaag aaggcctcga accgcgacgc        840

ttcacgatcg acctcctcga ccgcctccgc gacttgatgg tcctccaagc cgtcccagaa        900

gcactaaacc tcgggcttgt cgacgccccc accgaccgcg ccgacgccct aatcgaacaa        960

tccaccctgt tcaaaggcaa cgagctcgcc aacctagcct ccatggtgaa ctccggactc       1020

gacgacatgc gtggtgccac ctcaccgcgc ctccttctgg aaatcctctg cgcccgactg       1080

ctcctggcaa gcaataccgt ggcaggtcca gcggtcagta gttcgactga cgctgcgcct       1140

gcagctactc cgggtggtct cactggtatt gctgctgccc gcgcgaaagc acgggagtat       1200

ggacagaaga aggcagctcc agctcctgca ccaactcctg cgcccgagcc agtgcgcgaa       1260

cagtctcttg caccaacgcc tgaaccaacg ccagcggctg aacctacatc tcagcccgcg       1320

ccggaaccgg aacccgccag ggaaccagtg gtggaagtgc gggaggcgag cgtcgaaaag       1380

cagcctgcaa gcagtgatcc cctcgaaacc attcgaagcc gctggtcaga gctgcgcaac       1440

atcgtggaaa aacaaagtgt gcgcacctca atcatgctga ccgaagcgcg agttttggga       1500

ctgcgaggcg ataccctcgt gctcggtcac agcaccgggg cgttggctgc gcgtttgaac       1560

gctgctgatc acaacggaat tttggtcaag gtgttggctg aggaaactgg tctgcagctc       1620

aaggtcgaat gcattgtggg cacgaaccca gccgaagctg gatttaccgc ccagcctgct       1680

gtgcaaaaga gcacgtggaa ccccaactac gactccaaac cagccactcc aagtgcgcct       1740

gcgcagcctc agacgcctaa gcaagaatcc gtgcccaccg agccagagga gcctgagagt       1800

tcggctgaaa cttcgggatg ggggcaaccg gtaaaaatcg gtgggccagc acctgaggca       1860

cagactccaa cgcctccgcc tgctccggtg gttccggcta ctcctgctgc tccggctgcg       1920

ggtgctgcga aaccagcgtg gaaggaacgc gtcgaacaag ccgcggcaaa tgcagcgcaa       1980

caacgtcagc atcgccaggg cagctccgag cccttcgagc ggggtgttcc gctgccacca       2040

gaacctgacc tgccaccgga cccctatgga tacccagctg acgagggttt ccccgaacga       2100

aaccaagggt tccagcaaca gccagcgcct cccgttgagc aaccagctcc tgagcctgcg       2160

acggagccag ttccagcagt tgcgcctgag ccggaggtca gccagctatc tgaagaagag       2220

cagctgatcc gcgaagcaga cgaagagcca ggtgaaatgg atcgtcgtga tgcgaaaacc       2280

atcgcgatgg aactgcttgc tcaggaactc ggcgcgaaac ctttgtaa                    2328


<210>    7
<211>    775
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_DNA polymerase III subunits gamma and tau


<400>    7
Met Ala Leu Tyr Ser Lys Tyr Arg Pro Ala Ser Phe Gly Glu Leu Val
  1               5                  10                  15 

Gly Gln Ser Gln Val Thr Asp Pro Leu Ser Ala Ala Leu Asp Ser Gly
             20                  25                  30 

Arg Ile Asn His Ala Tyr Leu Phe Ser Gly Pro Arg Gly Cys Gly Lys
         35                  40                  45 

Thr Ser Ser Ala Arg Ile Leu Ala Arg Ser Leu Asn Cys Val Glu Gly
     50                  55                  60 

Pro Thr Ser Thr Pro Cys Gly Val Cys Asn Ser Cys Val Ala Leu Ala
 65                  70                  75                  80 

Pro Gly Gly Pro Gly Thr Leu Asp Val Thr Glu Leu Asp Ala Ala Ser
                 85                  90                  95 

Asn Asn Gly Val Asp Asp Met Arg Glu Leu Arg Glu Arg Ala Asn Tyr
            100                 105                 110 

Ala Pro Ala Glu Ser Arg Tyr Arg Val Phe Ile Ile Asp Glu Ala His
        115                 120                 125 

Met Ile Ser Thr Gln Gly Phe Asn Ala Leu Leu Lys Ile Val Glu Glu
    130                 135                 140 

Pro Pro Ala His Leu Ile Phe Ile Phe Ala Thr Thr Glu Pro Asp Lys
145                 150                 155                 160 

Met Ile Gly Thr Ile Arg Ser Arg Thr His Asn Tyr Pro Phe Arg Leu
                165                 170                 175 

Leu Thr Pro Gly Asp Met Arg Lys Val Leu Lys Asn Ala Val Asp Gly
            180                 185                 190 

Glu Gly Val His Val Asp Asp Ser Val Tyr Pro Leu Val Ile Arg Ala
        195                 200                 205 

Gly Gly Gly Ser Pro Arg Asp Ser Leu Ser Ile Leu Asp Gln Leu Ile
    210                 215                 220 

Ala Gly Ser Gly Pro Glu Gly Leu Thr Tyr Glu Arg Ala Leu Pro Leu
225                 230                 235                 240 

Leu Gly Val Thr Ser Phe Thr Leu Ile Asp Asp Ser Ile His Ala Leu
                245                 250                 255 

Ala Ser Lys Asp Asn Ala Ser Met Phe Thr Thr Ile Asp Asn Val Ile
            260                 265                 270 

Glu Glu Gly Leu Glu Pro Arg Arg Phe Thr Ile Asp Leu Leu Asp Arg
        275                 280                 285 

Leu Arg Asp Leu Met Val Leu Gln Ala Val Pro Glu Ala Leu Asn Leu
    290                 295                 300 

Gly Leu Val Asp Ala Pro Thr Asp Arg Ala Asp Ala Leu Ile Glu Gln
305                 310                 315                 320 

Ser Thr Leu Phe Lys Gly Asn Glu Leu Ala Asn Leu Ala Ser Met Val
                325                 330                 335 

Asn Ser Gly Leu Asp Asp Met Arg Gly Ala Thr Ser Pro Arg Leu Leu
            340                 345                 350 

Leu Glu Ile Leu Cys Ala Arg Leu Leu Leu Ala Ser Asn Thr Val Ala
        355                 360                 365 

Gly Pro Ala Val Ser Ser Ser Thr Asp Ala Ala Pro Ala Ala Thr Pro
    370                 375                 380 

Gly Gly Leu Thr Gly Ile Ala Ala Ala Arg Ala Lys Ala Arg Glu Tyr
385                 390                 395                 400 

Gly Gln Lys Lys Ala Ala Pro Ala Pro Ala Pro Thr Pro Ala Pro Glu
                405                 410                 415 

Pro Val Arg Glu Gln Ser Leu Ala Pro Thr Pro Glu Pro Thr Pro Ala
            420                 425                 430 

Ala Glu Pro Thr Ser Gln Pro Ala Pro Glu Pro Glu Pro Ala Arg Glu
        435                 440                 445 

Pro Val Val Glu Val Arg Glu Ala Ser Val Glu Lys Gln Pro Ala Ser
    450                 455                 460 

Ser Asp Pro Leu Glu Thr Ile Arg Ser Arg Trp Ser Glu Leu Arg Asn
465                 470                 475                 480 

Ile Val Glu Lys Gln Ser Val Arg Thr Ser Ile Met Leu Thr Glu Ala
                485                 490                 495 

Arg Val Leu Gly Leu Arg Gly Asp Thr Leu Val Leu Gly His Ser Thr
            500                 505                 510 

Gly Ala Leu Ala Ala Arg Leu Asn Ala Ala Asp His Asn Gly Ile Leu
        515                 520                 525 

Val Lys Val Leu Ala Glu Glu Thr Gly Leu Gln Leu Lys Val Glu Cys
    530                 535                 540 

Ile Val Gly Thr Asn Pro Ala Glu Ala Gly Phe Thr Ala Gln Pro Ala
545                 550                 555                 560 

Val Gln Lys Ser Thr Trp Asn Pro Asn Tyr Asp Ser Lys Pro Ala Thr
                565                 570                 575 

Pro Ser Ala Pro Ala Gln Pro Gln Thr Pro Lys Gln Glu Ser Val Pro
            580                 585                 590 

Thr Glu Pro Glu Glu Pro Glu Ser Ser Ala Glu Thr Ser Gly Trp Gly
        595                 600                 605 

Gln Pro Val Lys Ile Gly Gly Pro Ala Pro Glu Ala Gln Thr Pro Thr
    610                 615                 620 

Pro Pro Pro Ala Pro Val Val Pro Ala Thr Pro Ala Ala Pro Ala Ala
625                 630                 635                 640 

Gly Ala Ala Lys Pro Ala Trp Lys Glu Arg Val Glu Gln Ala Ala Ala
                645                 650                 655 

Asn Ala Ala Gln Gln Arg Gln His Arg Gln Gly Ser Ser Glu Pro Phe
            660                 665                 670 

Glu Arg Gly Val Pro Leu Pro Pro Glu Pro Asp Leu Pro Pro Asp Pro
        675                 680                 685 

Tyr Gly Tyr Pro Ala Asp Glu Gly Phe Pro Glu Arg Asn Gln Gly Phe
    690                 695                 700 

Gln Gln Gln Pro Ala Pro Pro Val Glu Gln Pro Ala Pro Glu Pro Ala
705                 710                 715                 720 

Thr Glu Pro Val Pro Ala Val Ala Pro Glu Pro Glu Val Ser Gln Leu
                725                 730                 735 

Ser Glu Glu Glu Gln Leu Ile Arg Glu Ala Asp Glu Glu Pro Gly Glu
            740                 745                 750 

Met Asp Arg Arg Asp Ala Lys Thr Ile Ala Met Glu Leu Leu Ala Gln
        755                 760                 765 

Glu Leu Gly Ala Lys Pro Leu
    770                 775


<210>    8
<211>    2328
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_dnaZX


<400>    8
gtggctttgt atagcaagta tcgaccggca agttttggtg aactagttgg gcagtcgcaa         60

gtgactgacc ctctgtccgc agctttggat agcgggcgca tcaaccatgc gtaccttttt        120

tcgggtccgc gtggttgtgg caagacgtcg tcggcacgca tccttgcccg gtccctcaac        180

tgcgtggaag gcccaacttc cacgccgtgt ggggtgtgta attcttgcgt agcgctggcc        240

ccgggtggcc ctggaaccct tgatgtaaca gagctcgacg ccgcgagtaa caatggtgtc        300

gatgacatgc gtgaactgcg cgaacgcgcg aactacgccc cggcggaatc tcgctaccgc        360

gtgttcatca ttgacgaagc ccacatgatc agtacccaag gcttcaacgc cttgctgaaa        420

atcgttgaag agccaccagc gcacctgatt ttcatcttcg ccaccaccga gccggacaaa        480

atgatcggta cgatccgttc ccgcacgcac aattacccat tccgcctgct caccccaggg        540

gatatgcgca aagtgctgaa aaatgcggtc gatggcgaag gcgtccacgt cgacgattcc        600

gtttacccac tggtcatccg cgccggcggc ggcagccccc gcgacagcct ctccatcctc        660

gaccagctca tcgccggctc gggcccggag ggcttgacat atgagcgcgc cttgccgctg        720

ctcggtgtca caagcttcac gcttatcgac gattcgatcc atgcccttgc atctaaagac        780

aacgcaagca tgttcaccac gatcgataac gtcatcgaag aaggcctcga accgcgacgc        840

ttcacgatcg acctcctcga ccgcctccgc gacttgatgg tcctccaagc cgtcccagaa        900

gcactaaacc tcgggcttgt cgacgccccc accgaccgcg ccgacgccct aatcgaacaa        960

tccaccctgt tcaaaggcaa cgagctcgcc aacctagcct ccatggtgaa ctccggactc       1020

gacgacatgc gtggtgccac ctcaccgcgc ctccttctgg aaatcctctg cgcccgactg       1080

ctcctggcaa gcaataccgt ggcaggtcca gcggtcagta gttcgactga cgctgcgcct       1140

gcagctactc cgggtggtct cactggtatt gctgctgccc gcgcgaaagc acgggagtat       1200

ggacagaaga aggcagctcc agctcctgca ccaactcctg cgcccgagcc agtgcgcgaa       1260

cagtctcttg caccaacgcc tgaaccaacg ccagcggctg aacctacatc tcagcccgcg       1320

ccggaaccgg aacccgccag ggaaccagtg gtggaagtgc gggaggcgag cgtcgaaaag       1380

cagcctgcaa gcagtgatcc cctcgaaacc attcgaagcc gctggtcaga gctgcgcaac       1440

atcgtggaaa aacaaagtgt gcgcacctca atcatgctga ccgaagcgcg agttttggga       1500

ctgcgaggcg ataccctcgt gctcggtcac agcaccgggg cgttggctgc gcgtttgaac       1560

gctgctgatc acaacggaat tttggtcaag gtgttggctg aggaaactgg tctgcagctc       1620

aaggtcgaat gcattgtggg cacgaaccca gccgaagctg gatttaccgc ccagcctgct       1680

gtgcaaaaga gcacgtggaa ccccaactac gactccaaac cagccactcc aagtgcgcct       1740

gcgcagcctc agacgcctaa gcaagaatcc gtgcccaccg agccagagga gcctgagagt       1800

tcggctgaaa cttcgggatg ggggcaaccg gtaaaaatcg gtgggccagc acctgaggca       1860

cagactccaa cgcctccgcc tgctccggtg gttccggcta ctcctgctgc tccggctgcg       1920

ggtgctgcga aaccagcgtg gaaggaacgc gtcgaacaag ccgcggcaaa tgcagcgcaa       1980

caacgtcagc atcgccaggg cagctccgag cccttcgagc ggggtgttcc gctgccacca       2040

gaacctgacc tgccaccgga cccctatgga tacccagctg acgagggttt ccccgaacga       2100

aaccaagggt tccagcaaca gccagcgcct cccgttgagc aaccagctcc tgagcctgcg       2160

acggagccag ttccagcagt tgcgcctgag ccggaggtca gccagctatc tgaagaagag       2220

cagctgatcc gcgaagcaga cgaagagcca ggtgaaatgg atcgtcgtga tgcgaaaacc       2280

atcgcgatgg aactgcttgc tcaggaactc ggcgcgaaac ctttgtaa                    2328


<210>    9
<211>    38
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (C33S)_NCgl3069_amino acid


<400>    9
Met Ala Val Ala Lys Asp Val Leu Ser Phe Ser Arg Pro Ile Pro Ala
  1               5                  10                  15 

Leu His Ala Ile Ile Gly Ala Leu Gly Trp Phe Gly Met Phe Ala Val
             20                  25                  30 

Ser Leu Trp Ser Thr Leu
         35            


<210>    10
<211>    117
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (C33S)_NCgl3069_nucleic acid


<400>    10
gtggctgtcg caaaagacgt gcttagtttt tcacgaccca ttcccgcact tcacgccatc         60

atcggcgcgc ttggatggtt tggaatgttc gcagttagtc tgtggagcac gctgtaa           117


<210>    11
<211>    38
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl3069_amino acid


<400>    11
Met Ala Val Ala Lys Asp Val Leu Ser Phe Ser Arg Pro Ile Pro Ala
  1               5                  10                  15 

Leu His Ala Ile Ile Gly Ala Leu Gly Trp Phe Gly Met Phe Ala Val
             20                  25                  30 

Cys Leu Trp Ser Thr Leu
         35            


<210>    12
<211>    117
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl3069_nucleic acid


<400>    12
gtggctgtcg caaaagacgt gcttagtttt tcacgaccca ttcccgcact tcacgccatc         60

atcggcgcgc ttggatggtt tggaatgttc gcagtttgtc tgtggagcac gctgtaa           117


<210>    13
<211>    318
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (N210D)_NusG


<400>    13
Met Ser Asp Glu Asn Ile Asn Glu Phe Glu Gln Asp Glu Asp Leu Asn
  1               5                  10                  15 

Phe Gly Ala Ser Phe Ser Asp Glu Phe Ala Asp Asp Asp Phe Asp Ala
             20                  25                  30 

Glu Ala Asp Val Glu Ala Asp Ala Ala Ala Glu Ala Ser Ala Leu Glu
         35                  40                  45 

Ala Glu Gln Asp Leu Glu Glu Glu Thr Leu Asp Ala Pro Glu Glu Ala
     50                  55                  60 

Ala Glu Glu Ala Pro Ala Ala Ala Glu Ser Glu Ala Pro Val Glu Glu
 65                  70                  75                  80 

Asp Glu Glu Ala Asp Ser Leu Ala Gln Ala Ala Ala Ala Leu Gly Asp
                 85                  90                  95 

Thr Asp Glu Gln Asp Ala Asp Ala Glu Tyr Lys Ala Arg Leu Arg Lys
            100                 105                 110 

Phe Thr Arg Glu Leu Lys Lys Gln Pro Gly Val Trp Tyr Ile Ile Gln
        115                 120                 125 

Cys Tyr Ser Gly Tyr Glu Asn Lys Val Lys Ala Asn Leu Asp Met Arg
    130                 135                 140 

Ala Gln Thr Leu Glu Val Glu Asp Asp Ile Phe Glu Val Val Val Pro
145                 150                 155                 160 

Ile Glu Gln Val Thr Glu Ile Arg Asp Gly Lys Arg Lys Leu Val Lys
                165                 170                 175 

Arg Lys Leu Leu Pro Gly Tyr Val Leu Val Arg Met Asp Met Asn Asp
            180                 185                 190 

Arg Val Trp Ser Val Val Arg Asp Thr Pro Gly Val Thr Ser Phe Val
        195                 200                 205 

Gly Asp Glu Gly Asn Ala Thr Pro Val Lys His Arg Asp Val Ala Lys
    210                 215                 220 

Phe Leu Met Pro Gln Glu Gln Ala Val Val Thr Gly Glu Ala Ala Ala
225                 230                 235                 240 

Ala Ala Ala Glu Gly Glu Gln Val Val Ala Met Pro Thr Asp Thr Lys
                245                 250                 255 

Lys Pro Gln Val Ala Val Asp Phe Thr Val Gly Glu Ala Val Thr Ile
            260                 265                 270 

Leu Thr Gly Ala Phe Ala Ser Val Ser Ala Thr Ile Ser Ser Ile Asp
        275                 280                 285 

Pro Glu Leu Gln Lys Leu Glu Val Leu Val Ser Ile Phe Gly Arg Glu
    290                 295                 300 

Thr Pro Val Asp Leu Ser Phe Asp Gln Val Glu Lys Val Ser
305                 310                 315            


<210>    14
<211>    957
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (N210D)_nusG


<400>    14
atgagcgatg agaacattaa cgagtttgag caggacgagg atctgaactt cggcgcgagc         60

tttagtgatg aattcgcaga tgacgatttc gatgcagaag cagacgtaga agcagatgct        120

gctgcagagg cctctgccct ggaagctgag caggatctgg aagaagagac cctagatgct        180

ccagaagaag ccgcagaaga agctcctgct gctgcagagt ccgaagctcc agtagaagag        240

gacgaagagg ctgacagcct tgctcaggcg gctgctgcac ttggtgacac cgatgagcag        300

gacgcggatg cagagtacaa ggctcgtctg cgtaagttca ctcgtgagct gaagaagcag        360

cctggtgttt ggtacatcat tcagtgctac tccggctacg agaacaaggt gaaggcgaac        420

cttgacatgc gtgctcagac ccttgaggtt gaggatgaca tctttgaggt tgttgttcct        480

atcgagcagg tcactgagat ccgtgatggt aagcgcaagc tggttaagcg taagttgctg        540

ccgggctacg ttttggtccg catggacatg aatgaccgcg tgtggtctgt tgttcgcgat        600

acacctggtg tgaccagctt tgtgggtgac gagggcaatg caactcctgt gaagcaccgc        660

gatgttgcga agttcttgat gcctcaggag caggctgttg tcaccggtga ggctgctgct        720

gcggctgccg agggtgagca ggttgtggct atgcctaccg ataccaagaa gcctcaggtt        780

gctgtggact tcactgttgg tgaggctgtg accattctga ctggtgcttt cgcttctgtt        840

tctgcaacga tttcttctat cgatcctgag ctgcagaagc tggaagtttt ggtgtccatc        900

tttggtcgtg aaactcctgt tgatctcagc ttcgaccagg ttgagaaggt tagctag           957


<210>    15
<211>    318
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_NusG


<400>    15
Met Ser Asp Glu Asn Ile Asn Glu Phe Glu Gln Asp Glu Asp Leu Asn
  1               5                  10                  15 

Phe Gly Ala Ser Phe Ser Asp Glu Phe Ala Asp Asp Asp Phe Asp Ala
             20                  25                  30 

Glu Ala Asp Val Glu Ala Asp Ala Ala Ala Glu Ala Ser Ala Leu Glu
         35                  40                  45 

Ala Glu Gln Asp Leu Glu Glu Glu Thr Leu Asp Ala Pro Glu Glu Ala
     50                  55                  60 

Ala Glu Glu Ala Pro Ala Ala Ala Glu Ser Glu Ala Pro Val Glu Glu
 65                  70                  75                  80 

Asp Glu Glu Ala Asp Ser Leu Ala Gln Ala Ala Ala Ala Leu Gly Asp
                 85                  90                  95 

Thr Asp Glu Gln Asp Ala Asp Ala Glu Tyr Lys Ala Arg Leu Arg Lys
            100                 105                 110 

Phe Thr Arg Glu Leu Lys Lys Gln Pro Gly Val Trp Tyr Ile Ile Gln
        115                 120                 125 

Cys Tyr Ser Gly Tyr Glu Asn Lys Val Lys Ala Asn Leu Asp Met Arg
    130                 135                 140 

Ala Gln Thr Leu Glu Val Glu Asp Asp Ile Phe Glu Val Val Val Pro
145                 150                 155                 160 

Ile Glu Gln Val Thr Glu Ile Arg Asp Gly Lys Arg Lys Leu Val Lys
                165                 170                 175 

Arg Lys Leu Leu Pro Gly Tyr Val Leu Val Arg Met Asp Met Asn Asp
            180                 185                 190 

Arg Val Trp Ser Val Val Arg Asp Thr Pro Gly Val Thr Ser Phe Val
        195                 200                 205 

Gly Asn Glu Gly Asn Ala Thr Pro Val Lys His Arg Asp Val Ala Lys
    210                 215                 220 

Phe Leu Met Pro Gln Glu Gln Ala Val Val Thr Gly Glu Ala Ala Ala
225                 230                 235                 240 

Ala Ala Ala Glu Gly Glu Gln Val Val Ala Met Pro Thr Asp Thr Lys
                245                 250                 255 

Lys Pro Gln Val Ala Val Asp Phe Thr Val Gly Glu Ala Val Thr Ile
            260                 265                 270 

Leu Thr Gly Ala Phe Ala Ser Val Ser Ala Thr Ile Ser Ser Ile Asp
        275                 280                 285 

Pro Glu Leu Gln Lys Leu Glu Val Leu Val Ser Ile Phe Gly Arg Glu
    290                 295                 300 

Thr Pro Val Asp Leu Ser Phe Asp Gln Val Glu Lys Val Ser
305                 310                 315            


<210>    16
<211>    957
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_nusG


<400>    16
atgagcgatg agaacattaa cgagtttgag caggacgagg atctgaactt cggcgcgagc         60

tttagtgatg aattcgcaga tgacgatttc gatgcagaag cagacgtaga agcagatgct        120

gctgcagagg cctctgccct ggaagctgag caggatctgg aagaagagac cctagatgct        180

ccagaagaag ccgcagaaga agctcctgct gctgcagagt ccgaagctcc agtagaagag        240

gacgaagagg ctgacagcct tgctcaggcg gctgctgcac ttggtgacac cgatgagcag        300

gacgcggatg cagagtacaa ggctcgtctg cgtaagttca ctcgtgagct gaagaagcag        360

cctggtgttt ggtacatcat tcagtgctac tccggctacg agaacaaggt gaaggcgaac        420

cttgacatgc gtgctcagac ccttgaggtt gaggatgaca tctttgaggt tgttgttcct        480

atcgagcagg tcactgagat ccgtgatggt aagcgcaagc tggttaagcg taagttgctg        540

ccgggctacg ttttggtccg catggacatg aatgaccgcg tgtggtctgt tgttcgcgat        600

acacctggtg tgaccagctt tgtgggtaac gagggcaatg caactcctgt gaagcaccgc        660

gatgttgcga agttcttgat gcctcaggag caggctgttg tcaccggtga ggctgctgct        720

gcggctgccg agggtgagca ggttgtggct atgcctaccg ataccaagaa gcctcaggtt        780

gctgtggact tcactgttgg tgaggctgtg accattctga ctggtgcttt cgcttctgtt        840

tctgcaacga tttcttctat cgatcctgag ctgcagaagc tggaagtttt ggtgtccatc        900

tttggtcgtg aaactcctgt tgatctcagc ttcgaccagg ttgagaaggt tagctag           957


<210>    17
<211>    269
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (V199M)_ABC transporter ATP-binding protein


<400>    17
Met Thr Thr Asn His Gln Leu Ser Ala Glu Glu Ile Ser Leu Ala Tyr
  1               5                  10                  15 

Gly Glu Arg Thr Ile Ile Asp Ser Leu Ser Val Asp Ile Val Pro Gly
             20                  25                  30 

Lys Ile Thr Ser Ile Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu
         35                  40                  45 

Leu Arg Ala Phe Ala Arg Leu Leu Lys Pro Ser Ala Gly Gln Ala Leu
     50                  55                  60 

Ile Asp Ala His Pro Leu Pro Ser Leu Pro Gly Lys Glu Leu Ala Arg
 65                  70                  75                  80 

Met Leu Gly Leu Leu Pro Gln Ser Pro Thr Ala Pro Glu Gly Ile Val
                 85                  90                  95 

Val Ala Asp Leu Val Gly Arg Gly Arg His Pro His Gln Gly Leu Met
            100                 105                 110 

Gly Arg Trp Ser Thr Arg Asp Tyr Glu Val Val Ala Gln Ala Leu Glu
        115                 120                 125 

Met Thr Asn Thr Thr Glu Leu Ala Glu Arg Pro Ile Asp Glu Leu Ser
    130                 135                 140 

Gly Gly Gln Arg Gln Arg Val Trp Ile Ala Met Ala Leu Ala Gln Glu
145                 150                 155                 160 

Thr Asp Ile Leu Leu Leu Asp Glu Pro Thr Thr Tyr Leu Asp Ile Ala
                165                 170                 175 

Asn Gln Leu Glu Val Leu Asp Leu Leu Thr Asp Leu Asn His Asn His
            180                 185                 190 

Gly Thr Thr Ile Val Met Met Leu His Glu Leu Gly Leu Ala Ala Arg
        195                 200                 205 

Tyr Ser Asp His Leu Ile Ala Met Asn Ala Gly Lys Ile Tyr Ala Gln
    210                 215                 220 

Gly Thr Pro Thr Asn Val Ile Thr Glu Thr Met Met Ser Glu Val Phe
225                 230                 235                 240 

His Thr Asp Ala Arg Ile Ile Ala Asp Pro Val Ser Gly Ala Pro Leu
                245                 250                 255 

Val Met Pro Met Gly Arg His His Ile Thr Ala Leu His
            260                 265                


<210>    18
<211>    810
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (V199M)_NCgl0636


<400>    18
gtgaccacca accatcaact atccgccgaa gaaatttccc tggcgtacgg cgagcgcacc         60

atcatcgatt cgctcagcgt cgacatcgtc cccggcaaaa tcacctccat cgtcggcccc        120

aacggatgcg gcaaatcaac gctgctgcgc gcctttgcgc gcctccttaa acctagcgcc        180

gggcaagcgc ttatcgacgc ccaccccctt ccttcactgc caggcaaaga actagctcgc        240

atgctcgggc tgttaccgca atcccccacc gcacctgaag gcatcgtcgt cgccgacctc        300

gtgggccgcg gccgccaccc ccaccaagga ctcatgggca gatggtccac acgcgactac        360

gaagtagtgg cccaagcatt ggaaatgacc aacaccaccg agcttgccga acgccccatc        420

gacgaactct ccggcggcca acgccaacgc gtctggatcg ccatggccct tgcccaagaa        480

acagacatcc tgcttcttga tgaacccacc acctacctcg acatcgccaa ccagctcgaa        540

gtgcttgatc tcctcactga cctcaaccac aaccacggca ccaccatcgt catgatgctc        600

cacgaattgg gacttgccgc acgttactct gaccacctca tcgccatgaa cgccggaaaa        660

atctacgccc aaggcacccc caccaacgtc atcaccgaaa ccatgatgag cgaggtcttc        720

cacaccgacg cccgcattat cgccgaccca gtctccggcg caccactggt catgcccatg        780

ggacgacacc acatcaccgc acttcactag                                         810


<210>    19
<211>    269
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_ABC transporter ATP-binding protein


<400>    19
Met Thr Thr Asn His Gln Leu Ser Ala Glu Glu Ile Ser Leu Ala Tyr
  1               5                  10                  15 

Gly Glu Arg Thr Ile Ile Asp Ser Leu Ser Val Asp Ile Val Pro Gly
             20                  25                  30 

Lys Ile Thr Ser Ile Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu
         35                  40                  45 

Leu Arg Ala Phe Ala Arg Leu Leu Lys Pro Ser Ala Gly Gln Ala Leu
     50                  55                  60 

Ile Asp Ala His Pro Leu Pro Ser Leu Pro Gly Lys Glu Leu Ala Arg
 65                  70                  75                  80 

Met Leu Gly Leu Leu Pro Gln Ser Pro Thr Ala Pro Glu Gly Ile Val
                 85                  90                  95 

Val Ala Asp Leu Val Gly Arg Gly Arg His Pro His Gln Gly Leu Met
            100                 105                 110 

Gly Arg Trp Ser Thr Arg Asp Tyr Glu Val Val Ala Gln Ala Leu Glu
        115                 120                 125 

Met Thr Asn Thr Thr Glu Leu Ala Glu Arg Pro Ile Asp Glu Leu Ser
    130                 135                 140 

Gly Gly Gln Arg Gln Arg Val Trp Ile Ala Met Ala Leu Ala Gln Glu
145                 150                 155                 160 

Thr Asp Ile Leu Leu Leu Asp Glu Pro Thr Thr Tyr Leu Asp Ile Ala
                165                 170                 175 

Asn Gln Leu Glu Val Leu Asp Leu Leu Thr Asp Leu Asn His Asn His
            180                 185                 190 

Gly Thr Thr Ile Val Met Val Leu His Glu Leu Gly Leu Ala Ala Arg
        195                 200                 205 

Tyr Ser Asp His Leu Ile Ala Met Asn Ala Gly Lys Ile Tyr Ala Gln
    210                 215                 220 

Gly Thr Pro Thr Asn Val Ile Thr Glu Thr Met Met Ser Glu Val Phe
225                 230                 235                 240 

His Thr Asp Ala Arg Ile Ile Ala Asp Pro Val Ser Gly Ala Pro Leu
                245                 250                 255 

Val Met Pro Met Gly Arg His His Ile Thr Ala Leu His
            260                 265                


<210>    20
<211>    810
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl0636


<400>    20
gtgaccacca accatcaact atccgccgaa gaaatttccc tggcgtacgg cgagcgcacc         60

atcatcgatt cgctcagcgt cgacatcgtc cccggcaaaa tcacctccat cgtcggcccc        120

aacggatgcg gcaaatcaac gctgctgcgc gcctttgcgc gcctccttaa acctagcgcc        180

gggcaagcgc ttatcgacgc ccaccccctt ccttcactgc caggcaaaga actagctcgc        240

atgctcgggc tgttaccgca atcccccacc gcacctgaag gcatcgtcgt cgccgacctc        300

gtgggccgcg gccgccaccc ccaccaagga ctcatgggca gatggtccac acgcgactac        360

gaagtagtgg cccaagcatt ggaaatgacc aacaccaccg agcttgccga acgccccatc        420

gacgaactct ccggcggcca acgccaacgc gtctggatcg ccatggccct tgcccaagaa        480

acagacatcc tgcttcttga tgaacccacc acctacctcg acatcgccaa ccagctcgaa        540

gtgcttgatc tcctcactga cctcaaccac aaccacggca ccaccatcgt catggtgctc        600

cacgaattgg gacttgccgc acgttactct gaccacctca tcgccatgaa cgccggaaaa        660

atctacgccc aaggcacccc caccaacgtc atcaccgaaa ccatgatgag cgaggtcttc        720

cacaccgacg cccgcattat cgccgaccca gtctccggcg caccactggt catgcccatg        780

ggacgacacc acatcaccgc acttcactag                                         810


<210>    21
<211>    328
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (T272I)_Malate dehydrogenase


<400>    21
Met Asn Ser Pro Gln Asn Val Ser Thr Lys Lys Val Thr Val Thr Gly
  1               5                  10                  15 

Ala Ala Gly Gln Ile Ser Tyr Ser Leu Leu Trp Arg Ile Ala Asn Gly
             20                  25                  30 

Glu Val Phe Gly Thr Asp Thr Pro Val Glu Leu Lys Leu Leu Glu Ile
         35                  40                  45 

Pro Gln Ala Leu Gly Gly Ala Glu Gly Val Ala Met Glu Leu Leu Asp
     50                  55                  60 

Ser Ala Phe Pro Leu Leu Arg Asn Ile Thr Ile Thr Ala Asp Ala Asn
 65                  70                  75                  80 

Glu Ala Phe Asp Gly Ala Asn Ala Ala Phe Leu Val Gly Ala Lys Pro
                 85                  90                  95 

Arg Gly Lys Gly Glu Glu Arg Ala Asp Leu Leu Ala Asn Asn Gly Lys
            100                 105                 110 

Ile Phe Gly Pro Gln Gly Lys Ala Ile Asn Asp Asn Ala Ala Asp Asp
        115                 120                 125 

Ile Arg Val Leu Val Val Gly Asn Pro Ala Asn Thr Asn Ala Leu Ile
    130                 135                 140 

Ala Ser Ala Ala Ala Pro Asp Val Pro Ala Ser Arg Phe Asn Ala Met
145                 150                 155                 160 

Met Arg Leu Asp His Asn Arg Ala Ile Ser Gln Leu Ala Thr Lys Leu
                165                 170                 175 

Gly Arg Gly Ser Ala Glu Phe Asn Asn Ile Val Val Trp Gly Asn His
            180                 185                 190 

Ser Ala Thr Gln Phe Pro Asp Ile Thr Tyr Ala Thr Val Gly Gly Glu
        195                 200                 205 

Lys Val Thr Asp Leu Val Asp His Asp Trp Tyr Val Glu Glu Phe Ile
    210                 215                 220 

Pro Arg Val Ala Asn Arg Gly Ala Glu Ile Ile Glu Val Arg Gly Lys
225                 230                 235                 240 

Ser Ser Ala Ala Ser Ala Ala Ser Ser Ala Ile Asp His Met Arg Asp
                245                 250                 255 

Trp Val Gln Gly Thr Glu Ala Trp Ser Ser Ala Ala Ile Pro Ser Ile
            260                 265                 270 

Gly Ala Tyr Gly Ile Pro Glu Gly Ile Phe Val Gly Leu Pro Thr Val
        275                 280                 285 

Ser Arg Asn Gly Glu Trp Glu Ile Val Glu Gly Leu Glu Ile Ser Asp
    290                 295                 300 

Phe Gln Arg Ala Arg Ile Asp Ala Asn Ala Gln Glu Leu Gln Ala Glu
305                 310                 315                 320 

Arg Glu Ala Val Arg Asp Leu Leu
                325            


<210>    22
<211>    987
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (T272I)_NCgl2297


<400>    22
atgaattccc cgcagaacgt ctccaccaag aaggtcaccg tcaccggcgc agctggtcaa         60

atctcttatt cactgttgtg gcgcatcgcc aacggtgaag tattcggcac cgacacccct        120

gtagaactga aacttctgga gatccctcag gctcttggcg gggcagaggg tgtggctatg        180

gaacttctgg attctgcctt ccccctcctg cgaaacatca ccatcaccgc ggatgccaat        240

gaggcattcg acggcgctaa tgcggcgttt ttggtcggtg cgaagcctcg cggaaaaggc        300

gaagagcgcg cagatttgct ggctaacaac ggcaagattt tcggacctca aggtaaagct        360

atcaatgaca acgccgcaga tgacattcgt gtcctagttg ttggaaaccc agcgaacacc        420

aacgcgttga ttgcttcagc tgcggcccca gatgttccag catcccgctt caacgcaatg        480

atgcgccttg atcacaaccg tgcgatctcc cagctggcca ccaagcttgg ccgtggatct        540

gcggaattta acaacattgt ggtctgggga aatcactccg caacccagtt cccagacatc        600

acctacgcaa ccgttggtgg agaaaaggtc actgacctgg ttgatcacga ttggtatgtg        660

gaggagttca ttcctcgcgt ggctaaccgt ggcgctgaaa tcattgaggt ccgtggaaag        720

tcttctgcag cttctgcagc atcctctgcg attgatcaca tgcgcgattg ggtacagggc        780

accgaggcgt ggtcctctgc ggcaattcct tccatcggtg catacggcat tcctgagggc        840

atttttgtcg gtctgccaac cgtatcccgc aacggtgagt gggaaatcgt tgaaggcctg        900

gagatttccg atttccagcg cgcccgcatc gacgcgaatg ctcaggaatt gcaggccgag        960

cgcgaggcag tgcgcgactt gctctaa                                            987


<210>    23
<211>    328
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_Malate dehydrogenase


<400>    23
Met Asn Ser Pro Gln Asn Val Ser Thr Lys Lys Val Thr Val Thr Gly
  1               5                  10                  15 

Ala Ala Gly Gln Ile Ser Tyr Ser Leu Leu Trp Arg Ile Ala Asn Gly
             20                  25                  30 

Glu Val Phe Gly Thr Asp Thr Pro Val Glu Leu Lys Leu Leu Glu Ile
         35                  40                  45 

Pro Gln Ala Leu Gly Gly Ala Glu Gly Val Ala Met Glu Leu Leu Asp
     50                  55                  60 

Ser Ala Phe Pro Leu Leu Arg Asn Ile Thr Ile Thr Ala Asp Ala Asn
 65                  70                  75                  80 

Glu Ala Phe Asp Gly Ala Asn Ala Ala Phe Leu Val Gly Ala Lys Pro
                 85                  90                  95 

Arg Gly Lys Gly Glu Glu Arg Ala Asp Leu Leu Ala Asn Asn Gly Lys
            100                 105                 110 

Ile Phe Gly Pro Gln Gly Lys Ala Ile Asn Asp Asn Ala Ala Asp Asp
        115                 120                 125 

Ile Arg Val Leu Val Val Gly Asn Pro Ala Asn Thr Asn Ala Leu Ile
    130                 135                 140 

Ala Ser Ala Ala Ala Pro Asp Val Pro Ala Ser Arg Phe Asn Ala Met
145                 150                 155                 160 

Met Arg Leu Asp His Asn Arg Ala Ile Ser Gln Leu Ala Thr Lys Leu
                165                 170                 175 

Gly Arg Gly Ser Ala Glu Phe Asn Asn Ile Val Val Trp Gly Asn His
            180                 185                 190 

Ser Ala Thr Gln Phe Pro Asp Ile Thr Tyr Ala Thr Val Gly Gly Glu
        195                 200                 205 

Lys Val Thr Asp Leu Val Asp His Asp Trp Tyr Val Glu Glu Phe Ile
    210                 215                 220 

Pro Arg Val Ala Asn Arg Gly Ala Glu Ile Ile Glu Val Arg Gly Lys
225                 230                 235                 240 

Ser Ser Ala Ala Ser Ala Ala Ser Ser Ala Ile Asp His Met Arg Asp
                245                 250                 255 

Trp Val Gln Gly Thr Glu Ala Trp Ser Ser Ala Ala Ile Pro Ser Thr
            260                 265                 270 

Gly Ala Tyr Gly Ile Pro Glu Gly Ile Phe Val Gly Leu Pro Thr Val
        275                 280                 285 

Ser Arg Asn Gly Glu Trp Glu Ile Val Glu Gly Leu Glu Ile Ser Asp
    290                 295                 300 

Phe Gln Arg Ala Arg Ile Asp Ala Asn Ala Gln Glu Leu Gln Ala Glu
305                 310                 315                 320 

Arg Glu Ala Val Arg Asp Leu Leu
                325            


<210>    24
<211>    987
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl2297


<400>    24
atgaattccc cgcagaacgt ctccaccaag aaggtcaccg tcaccggcgc agctggtcaa         60

atctcttatt cactgttgtg gcgcatcgcc aacggtgaag tattcggcac cgacacccct        120

gtagaactga aacttctgga gatccctcag gctcttggcg gggcagaggg tgtggctatg        180

gaacttctgg attctgcctt ccccctcctg cgaaacatca ccatcaccgc ggatgccaat        240

gaggcattcg acggcgctaa tgcggcgttt ttggtcggtg cgaagcctcg cggaaaaggc        300

gaagagcgcg cagatttgct ggctaacaac ggcaagattt tcggacctca aggtaaagct        360

atcaatgaca acgccgcaga tgacattcgt gtcctagttg ttggaaaccc agcgaacacc        420

aacgcgttga ttgcttcagc tgcggcccca gatgttccag catcccgctt caacgcaatg        480

atgcgccttg atcacaaccg tgcgatctcc cagctggcca ccaagcttgg ccgtggatct        540

gcggaattta acaacattgt ggtctgggga aatcactccg caacccagtt cccagacatc        600

acctacgcaa ccgttggtgg agaaaaggtc actgacctgg ttgatcacga ttggtatgtg        660

gaggagttca ttcctcgcgt ggctaaccgt ggcgctgaaa tcattgaggt ccgtggaaag        720

tcttctgcag cttctgcagc atcctctgcg attgatcaca tgcgcgattg ggtacagggc        780

accgaggcgt ggtcctctgc ggcaattcct tccaccggtg catacggcat tcctgagggc        840

atttttgtcg gtctgccaac cgtatcccgc aacggtgagt gggaaatcgt tgaaggcctg        900

gagatttccg atttccagcg cgcccgcatc gacgcgaatg ctcaggaatt gcaggccgag        960

cgcgaggcag tgcgcgactt gctctaa                                            987


<210>    25
<211>    688
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (R304Q)_primosome assembly protein


<400>    25
Met Ala Lys Thr Arg Val Pro Ala Pro Glu Lys Ser Val Ala Arg Val
  1               5                  10                  15 

Leu Pro Leu Leu Gly Leu Pro His Leu Asp Arg Leu Phe Asp Tyr Arg
             20                  25                  30 

Ile Ser Glu Asp Gln His Asp Asp Val Gln Pro Gly Val Arg Val Arg
         35                  40                  45 

Val Arg Phe Gly Gly Arg Leu Val Asp Ala Ile Val Met Ser Arg Thr
     50                  55                  60 

Ala Gln Thr Ser His Glu Gly Lys Leu Met Trp Leu Asp Arg Val Ile
 65                  70                  75                  80 

Ser Pro Ile Val Val Tyr Pro Pro Gln Thr Ala Lys Leu Ile Glu Gln
                 85                  90                  95 

Leu Ser Asp Arg Tyr Gly Gly Val Arg Ser Asp Leu Ile Arg Ser Ala
            100                 105                 110 

Leu Pro Ala Arg His Ala Gly Ala Glu Glu Ala Asp Thr Ser Thr Ser
        115                 120                 125 

Trp Glu Ser Leu Gly Glu Val Lys Glu Pro Asp Leu Ser Ser Trp Ser
    130                 135                 140 

Ala Tyr Gln His Gly Gln Ser Phe Val Asp Ala Val Leu Ala Gly Thr
145                 150                 155                 160 

Thr Ala Arg Ala Ser Trp Gln Ile Ala Pro Gly Asp Asp Trp Ala Leu
                165                 170                 175 

Ala Leu Ala Ser Leu Ala Val Lys Val Val Lys Asp Gly Gly Gly Ala
            180                 185                 190 

Leu Leu Val Val Pro Asp Gln Arg Asp Leu Asp Arg Leu Glu Ala Ala
        195                 200                 205 

Leu Arg Gly Leu Val Ala Ala Lys Gln Ile Thr Val Leu Asn Ser Gly
    210                 215                 220 

Leu Gly Pro Gln Ala Arg Tyr Arg Arg Phe Leu Ser Val Leu Ser Gly
225                 230                 235                 240 

Gln Gly Arg Leu Ile Ile Gly Thr Arg Ser Ala Ala Phe Ala Pro Val
                245                 250                 255 

Lys Asp Leu Lys Leu Ala Val Ile Leu Asn Asp Gly Asp Asp Asn Leu
            260                 265                 270 

Val Asp Pro Arg Ala Pro Tyr Ala His Ala Arg Glu Val Leu Thr Thr
        275                 280                 285 

Arg Ser Ser Leu Glu Ala Ser Ser Leu Ile Ile Ala Gly His Ala Gln
    290                 295                 300 

Thr Ala Glu Thr Gln Leu Leu Val Glu Ser Gly Trp Met His Asn Leu
305                 310                 315                 320 

Ile Ala Pro Arg Asp Thr Ile Arg Thr Arg Met Pro Arg Ile Gln Ala
                325                 330                 335 

Val Gly Asp Ser Asp Phe Gln Met Glu Arg Asp Pro Met Ala Arg Ser
            340                 345                 350 

Ala Arg Leu Pro Gly Ile Ala Phe His Ala Val Arg Ser Ala Leu Glu
        355                 360                 365 

Arg Asp Gln Pro Ala Leu Ile Gln Val Pro Arg Lys Gly Tyr Val Pro
    370                 375                 380 

Thr Leu Ala Cys Gly Asn Cys Arg Thr Pro Ala Arg Cys Arg His Cys
385                 390                 395                 400 

Asn Gly Pro Val Gly Leu Pro Gln Gly Ser Ser Asp Leu Ala Gly Val
                405                 410                 415 

Pro Thr Cys Arg Trp Cys Gly Arg Pro Asp Ser Arg Phe Lys Cys Gln
            420                 425                 430 

Asn Cys Gly Ser Pro Lys Leu Arg Ala Val Val Leu Gly Thr Glu Arg
        435                 440                 445 

Thr Ala Glu Glu Leu Gly Arg Ala Phe Pro Ser Val Arg Val Ile Thr
    450                 455                 460 

Ser Gly Gly Asn Lys Val Val Asp Ser Val Glu Asn Arg Ala Ser Ile
465                 470                 475                 480 

Val Val Ser Thr Pro Gly Ala Glu Pro Phe Val Ala Asn Ser Pro Glu
                485                 490                 495 

Arg Pro Glu Lys Ser Glu Lys Pro Glu His Lys Gly Ala Tyr Gly Ala
            500                 505                 510 

Leu Leu Leu Leu Asp Thr Trp Ala Leu Met Gly Arg Gln Asp Leu Arg
        515                 520                 525 

Ala Met Glu Asp Ala Leu His Lys Trp Ala Ala Ala Ala Thr Leu Val
    530                 535                 540 

His Ser His Leu His Gln Gly Gln Val Ile Val Val Ala Asp Pro Ser
545                 550                 555                 560 

Phe Pro Ala Val Gln Ser Leu Ile Arg Trp Asp Met Ala Gly Ala Ala
                565                 570                 575 

Ala Gln Glu Leu Ala Ser Arg Arg Glu Val Met Phe Pro Pro Ser Val
            580                 585                 590 

His Met Ala Ala Ile Asp Gly Ala Thr Ala Ala Leu Glu Ser Phe Leu
        595                 600                 605 

Asp Leu Ala Glu Leu Pro Asp His Ala Glu Val Leu Gly Pro Val Asp
    610                 615                 620 

Leu Pro Pro Gly Val Ser Leu Pro Gly Glu Tyr Asp Glu Gln Arg Phe
625                 630                 635                 640 

Gly Pro Pro Gln Arg Leu Leu Ile Arg Thr Pro Leu Gly Pro Arg Ser
                645                 650                 655 

Glu Leu Gly Arg Ala Leu Arg Ser Ala Gln Val Ala Arg Ala Val Arg
            660                 665                 670 

Lys Asn Asp Leu Pro Leu Arg Ile Gln Met Asp Pro Ile His Ile Gly
        675                 680                 685 




<210>    26
<211>    2067
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (R304Q)_NCgl1540


<400>    26
atggcaaaaa cccgcgtccc cgctcctgaa aagtcggtgg cgcgggtttt acctcttttg         60

gggttacctc acctggatcg actgtttgat taccgcatca gcgaagacca acacgatgat        120

gtgcaacctg gcgtgcgggt gcgcgtgcgt tttggtggac gtttagttga tgccatcgtg        180

atgtcacgca ccgcgcaaac ctcgcacgag ggaaagctga tgtggctgga tcgggtgatt        240

tcgccgatcg tggtgtatcc acctcaaaca gcaaagctaa ttgagcaact cagtgatcgc        300

tatggcgggg tacgttcgga tctcatccgt tcggcgctac cggcgcggca tgctggggca        360

gaagaggcag atacctccac gtcgtgggag tcattgggtg aggttaaaga acccgattta        420

tcgtcgtggt ctgcgtatca gcatggtcaa tcatttgttg acgccgtctt ggcgggaaca        480

actgcgcggg cgtcatggca gattgctccc ggagatgatt gggcgctggc tttggcttct        540

ttggcggtca aggttgtcaa agacggcggc ggagcgcttc tcgtagtgcc tgatcagcgc        600

gatctcgacc gcttggaagc tgcgcttcga ggtttggttg cggcgaaaca aatcactgtg        660

cttaattcag gtcttggtcc gcaggcacga tatcggcgtt tcctatcggt actcagtggg        720

cagggacgac tgattattgg aaccagaagt gccgcttttg cacccgtgaa ggatctgaaa        780

ctggccgtca ttttaaatga tggcgacgac aacctcgttg atcctagagc gccctatgcc        840

cacgccaggg aagtgctgac cacgcgttcc agtttggaag caagctcctt gattattgcg        900

ggacatgcgc agaccgcgga aacccaattg ctggtggaat cgggatggat gcacaatctc        960

atcgcaccga gggataccat tcgcactagg atgccgcgta ttcaggcagt gggcgattcc       1020

gatttccaga tggaacgcga tccaatggcc cgatcagcgc ggctgcctgg cattgcgttt       1080

catgcggtgc gcagcgcctt agaacgtgat caaccagcgc ttatccaggt accaaggaaa       1140

ggctacgtgc caaccttggc gtgtggaaac tgccgcaccc cagcgcggtg ccggcactgt       1200

aatgggcctg tgggacttcc ccagggaagc tctgatctag cgggagtgcc cacttgccga       1260

tggtgcggac gccctgattc gcggtttaag tgccaaaact gcggctctcc aaaactgcgt       1320

gctgtggtgc tgggaacgga acgcacagca gaagaactgg gccgcgcgtt cccgtctgtg       1380

cgggtaatta cctctggtgg caacaaggtg gtggattcgg tggaaaaccg agccagcatt       1440

gtggtgtcca cgccaggtgc agaacctttt gtggccaact cgccggagag accagagaaa       1500

tcggagaaac cagagcacaa gggcgcttac ggtgccttgt tattgctgga tacctgggcg       1560

ttgatgggtc ggcaagatct gcgcgccatg gaggacgcgc tgcacaagtg ggcagcggcg       1620

gccacgctgg tgcattctca tctgcaccag ggtcaagtca tcgtggttgc agatccatcg       1680

tttcctgctg tgcaatcgtt gattcggtgg gatatggcag gtgctgcagc gcaagagttg       1740

gctagccgac gcgaggttat gttcccgcct tctgtacaca tggcagcaat cgatggggct       1800

accgctgcat tggaaagttt cttggatttg gcggagcttc ccgatcatgc tgaagtcctc       1860

ggccctgttg atctgccacc gggtgtgagt ttgcctggtg aatatgatga gcagcgcttt       1920

ggtccgccgc agcgccttct catcagaact ccattgggac cgcggtctga gttgggtaga       1980

gcgctgcgct cagcccaggt ggcgcgtgcg gtgaggaaga atgatttgcc gttgcgtatt       2040

cagatggatc cgattcacat cggataa                                           2067


<210>    27
<211>    688
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_primosome assembly protein


<400>    27
Met Ala Lys Thr Arg Val Pro Ala Pro Glu Lys Ser Val Ala Arg Val
  1               5                  10                  15 

Leu Pro Leu Leu Gly Leu Pro His Leu Asp Arg Leu Phe Asp Tyr Arg
             20                  25                  30 

Ile Ser Glu Asp Gln His Asp Asp Val Gln Pro Gly Val Arg Val Arg
         35                  40                  45 

Val Arg Phe Gly Gly Arg Leu Val Asp Ala Ile Val Met Ser Arg Thr
     50                  55                  60 

Ala Gln Thr Ser His Glu Gly Lys Leu Met Trp Leu Asp Arg Val Ile
 65                  70                  75                  80 

Ser Pro Ile Val Val Tyr Pro Pro Gln Thr Ala Lys Leu Ile Glu Gln
                 85                  90                  95 

Leu Ser Asp Arg Tyr Gly Gly Val Arg Ser Asp Leu Ile Arg Ser Ala
            100                 105                 110 

Leu Pro Ala Arg His Ala Gly Ala Glu Glu Ala Asp Thr Ser Thr Ser
        115                 120                 125 

Trp Glu Ser Leu Gly Glu Val Lys Glu Pro Asp Leu Ser Ser Trp Ser
    130                 135                 140 

Ala Tyr Gln His Gly Gln Ser Phe Val Asp Ala Val Leu Ala Gly Thr
145                 150                 155                 160 

Thr Ala Arg Ala Ser Trp Gln Ile Ala Pro Gly Asp Asp Trp Ala Leu
                165                 170                 175 

Ala Leu Ala Ser Leu Ala Val Lys Val Val Lys Asp Gly Gly Gly Ala
            180                 185                 190 

Leu Leu Val Val Pro Asp Gln Arg Asp Leu Asp Arg Leu Glu Ala Ala
        195                 200                 205 

Leu Arg Gly Leu Val Ala Ala Lys Gln Ile Thr Val Leu Asn Ser Gly
    210                 215                 220 

Leu Gly Pro Gln Ala Arg Tyr Arg Arg Phe Leu Ser Val Leu Ser Gly
225                 230                 235                 240 

Gln Gly Arg Leu Ile Ile Gly Thr Arg Ser Ala Ala Phe Ala Pro Val
                245                 250                 255 

Lys Asp Leu Lys Leu Ala Val Ile Leu Asn Asp Gly Asp Asp Asn Leu
            260                 265                 270 

Val Asp Pro Arg Ala Pro Tyr Ala His Ala Arg Glu Val Leu Thr Thr
        275                 280                 285 

Arg Ser Ser Leu Glu Ala Ser Ser Leu Ile Ile Ala Gly His Ala Arg
    290                 295                 300 

Thr Ala Glu Thr Gln Leu Leu Val Glu Ser Gly Trp Met His Asn Leu
305                 310                 315                 320 

Ile Ala Pro Arg Asp Thr Ile Arg Thr Arg Met Pro Arg Ile Gln Ala
                325                 330                 335 

Val Gly Asp Ser Asp Phe Gln Met Glu Arg Asp Pro Met Ala Arg Ser
            340                 345                 350 

Ala Arg Leu Pro Gly Ile Ala Phe His Ala Val Arg Ser Ala Leu Glu
        355                 360                 365 

Arg Asp Gln Pro Ala Leu Ile Gln Val Pro Arg Lys Gly Tyr Val Pro
    370                 375                 380 

Thr Leu Ala Cys Gly Asn Cys Arg Thr Pro Ala Arg Cys Arg His Cys
385                 390                 395                 400 

Asn Gly Pro Val Gly Leu Pro Gln Gly Ser Ser Asp Leu Ala Gly Val
                405                 410                 415 

Pro Thr Cys Arg Trp Cys Gly Arg Pro Asp Ser Arg Phe Lys Cys Gln
            420                 425                 430 

Asn Cys Gly Ser Pro Lys Leu Arg Ala Val Val Leu Gly Thr Glu Arg
        435                 440                 445 

Thr Ala Glu Glu Leu Gly Arg Ala Phe Pro Ser Val Arg Val Ile Thr
    450                 455                 460 

Ser Gly Gly Asn Lys Val Val Asp Ser Val Glu Asn Arg Ala Ser Ile
465                 470                 475                 480 

Val Val Ser Thr Pro Gly Ala Glu Pro Phe Val Ala Asn Ser Pro Glu
                485                 490                 495 

Arg Pro Glu Lys Ser Glu Lys Pro Glu His Lys Gly Ala Tyr Gly Ala
            500                 505                 510 

Leu Leu Leu Leu Asp Thr Trp Ala Leu Met Gly Arg Gln Asp Leu Arg
        515                 520                 525 

Ala Met Glu Asp Ala Leu His Lys Trp Ala Ala Ala Ala Thr Leu Val
    530                 535                 540 

His Ser His Leu His Gln Gly Gln Val Ile Val Val Ala Asp Pro Ser
545                 550                 555                 560 

Phe Pro Ala Val Gln Ser Leu Ile Arg Trp Asp Met Ala Gly Ala Ala
                565                 570                 575 

Ala Gln Glu Leu Ala Ser Arg Arg Glu Val Met Phe Pro Pro Ser Val
            580                 585                 590 

His Met Ala Ala Ile Asp Gly Ala Thr Ala Ala Leu Glu Ser Phe Leu
        595                 600                 605 

Asp Leu Ala Glu Leu Pro Asp His Ala Glu Val Leu Gly Pro Val Asp
    610                 615                 620 

Leu Pro Pro Gly Val Ser Leu Pro Gly Glu Tyr Asp Glu Gln Arg Phe
625                 630                 635                 640 

Gly Pro Pro Gln Arg Leu Leu Ile Arg Thr Pro Leu Gly Pro Arg Ser
                645                 650                 655 

Glu Leu Gly Arg Ala Leu Arg Ser Ala Gln Val Ala Arg Ala Val Arg
            660                 665                 670 

Lys Asn Asp Leu Pro Leu Arg Ile Gln Met Asp Pro Ile His Ile Gly
        675                 680                 685 




<210>    28
<211>    2067
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl1540


<400>    28
atggcaaaaa cccgcgtccc cgctcctgaa aagtcggtgg cgcgggtttt acctcttttg         60

gggttacctc acctggatcg actgtttgat taccgcatca gcgaagacca acacgatgat        120

gtgcaacctg gcgtgcgggt gcgcgtgcgt tttggtggac gtttagttga tgccatcgtg        180

atgtcacgca ccgcgcaaac ctcgcacgag ggaaagctga tgtggctgga tcgggtgatt        240

tcgccgatcg tggtgtatcc acctcaaaca gcaaagctaa ttgagcaact cagtgatcgc        300

tatggcgggg tacgttcgga tctcatccgt tcggcgctac cggcgcggca tgctggggca        360

gaagaggcag atacctccac gtcgtgggag tcattgggtg aggttaaaga acccgattta        420

tcgtcgtggt ctgcgtatca gcatggtcaa tcatttgttg acgccgtctt ggcgggaaca        480

actgcgcggg cgtcatggca gattgctccc ggagatgatt gggcgctggc tttggcttct        540

ttggcggtca aggttgtcaa agacggcggc ggagcgcttc tcgtagtgcc tgatcagcgc        600

gatctcgacc gcttggaagc tgcgcttcga ggtttggttg cggcgaaaca aatcactgtg        660

cttaattcag gtcttggtcc gcaggcacga tatcggcgtt tcctatcggt actcagtggg        720

cagggacgac tgattattgg aaccagaagt gccgcttttg cacccgtgaa ggatctgaaa        780

ctggccgtca ttttaaatga tggcgacgac aacctcgttg atcctagagc gccctatgcc        840

cacgccaggg aagtgctgac cacgcgttcc agtttggaag caagctcctt gattattgcg        900

ggacatgcgc ggaccgcgga aacccaattg ctggtggaat cgggatggat gcacaatctc        960

atcgcaccga gggataccat tcgcactagg atgccgcgta ttcaggcagt gggcgattcc       1020

gatttccaga tggaacgcga tccaatggcc cgatcagcgc ggctgcctgg cattgcgttt       1080

catgcggtgc gcagcgcctt agaacgtgat caaccagcgc ttatccaggt accaaggaaa       1140

ggctacgtgc caaccttggc gtgtggaaac tgccgcaccc cagcgcggtg ccggcactgt       1200

aatgggcctg tgggacttcc ccagggaagc tctgatctag cgggagtgcc cacttgccga       1260

tggtgcggac gccctgattc gcggtttaag tgccaaaact gcggctctcc aaaactgcgt       1320

gctgtggtgc tgggaacgga acgcacagca gaagaactgg gccgcgcgtt cccgtctgtg       1380

cgggtaatta cctctggtgg caacaaggtg gtggattcgg tggaaaaccg agccagcatt       1440

gtggtgtcca cgccaggtgc agaacctttt gtggccaact cgccggagag accagagaaa       1500

tcggagaaac cagagcacaa gggcgcttac ggtgccttgt tattgctgga tacctgggcg       1560

ttgatgggtc ggcaagatct gcgcgccatg gaggacgcgc tgcacaagtg ggcagcggcg       1620

gccacgctgg tgcattctca tctgcaccag ggtcaagtca tcgtggttgc agatccatcg       1680

tttcctgctg tgcaatcgtt gattcggtgg gatatggcag gtgctgcagc gcaagagttg       1740

gctagccgac gcgaggttat gttcccgcct tctgtacaca tggcagcaat cgatggggct       1800

accgctgcat tggaaagttt cttggatttg gcggagcttc ccgatcatgc tgaagtcctc       1860

ggccctgttg atctgccacc gggtgtgagt ttgcctggtg aatatgatga gcagcgcttt       1920

ggtccgccgc agcgccttct catcagaact ccattgggac cgcggtctga gttgggtaga       1980

gcgctgcgct cagcccaggt ggcgcgtgcg gtgaggaaga atgatttgcc gttgcgtatt       2040

cagatggatc cgattcacat cggataa                                           2067


<210>    29
<211>    437
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (A169V)_type II citrate synthase


<400>    29
Met Phe Glu Arg Asp Ile Val Ala Thr Asp Asn Asn Lys Ala Val Leu
  1               5                  10                  15 

His Tyr Pro Gly Gly Glu Phe Glu Met Asp Ile Ile Glu Ala Ser Glu
             20                  25                  30 

Gly Asn Asn Gly Val Val Leu Gly Lys Met Leu Ser Glu Thr Gly Leu
         35                  40                  45 

Ile Thr Phe Asp Pro Gly Tyr Val Ser Thr Gly Ser Thr Glu Ser Lys
     50                  55                  60 

Ile Thr Tyr Ile Asp Gly Asp Ala Gly Ile Leu Arg Tyr Arg Gly Tyr
 65                  70                  75                  80 

Asp Ile Ala Asp Leu Ala Glu Asn Ala Thr Phe Asn Glu Val Ser Tyr
                 85                  90                  95 

Leu Leu Ile Asn Gly Glu Leu Pro Thr Pro Asp Glu Leu His Lys Phe
            100                 105                 110 

Asn Asp Glu Ile Arg His His Thr Leu Leu Asp Glu Asp Phe Lys Ser
        115                 120                 125 

Gln Phe Asn Val Phe Pro Arg Asp Ala His Pro Met Ala Thr Leu Ala
    130                 135                 140 

Ser Ser Val Asn Ile Leu Ser Thr Tyr Tyr Gln Asp Gln Leu Asn Pro
145                 150                 155                 160 

Leu Asp Glu Ala Gln Leu Asp Lys Val Thr Val Arg Leu Met Ala Lys
                165                 170                 175 

Val Pro Met Leu Ala Ala Tyr Ala His Arg Ala Arg Lys Gly Ala Pro
            180                 185                 190 

Tyr Met Tyr Pro Asp Asn Ser Leu Asn Ala Arg Glu Asn Phe Leu Arg
        195                 200                 205 

Met Met Phe Gly Tyr Pro Thr Glu Pro Tyr Glu Ile Asp Pro Ile Met
    210                 215                 220 

Val Lys Ala Leu Asp Lys Leu Leu Ile Leu His Ala Asp His Glu Gln
225                 230                 235                 240 

Asn Cys Ser Thr Ser Thr Val Arg Met Ile Gly Ser Ala Gln Ala Asn
                245                 250                 255 

Met Phe Val Ser Ile Ala Gly Gly Ile Asn Ala Leu Ser Gly Pro Leu
            260                 265                 270 

His Gly Gly Ala Asn Gln Ala Val Leu Glu Met Leu Glu Asp Ile Lys
        275                 280                 285 

Ser Asn His Gly Gly Asp Ala Thr Glu Phe Met Asn Lys Val Lys Asn
    290                 295                 300 

Lys Glu Asp Gly Val Arg Leu Met Gly Phe Gly His Arg Val Tyr Lys
305                 310                 315                 320 

Asn Tyr Asp Pro Arg Ala Ala Ile Val Lys Glu Thr Ala His Glu Ile
                325                 330                 335 

Leu Glu His Leu Gly Gly Asp Asp Leu Leu Asp Leu Ala Ile Lys Leu
            340                 345                 350 

Glu Glu Ile Ala Leu Ala Asp Asp Tyr Phe Ile Ser Arg Lys Leu Tyr
        355                 360                 365 

Pro Asn Val Asp Phe Tyr Thr Gly Leu Ile Tyr Arg Ala Met Gly Phe
    370                 375                 380 

Pro Thr Asp Phe Phe Thr Val Leu Phe Ala Ile Gly Arg Leu Pro Gly
385                 390                 395                 400 

Trp Ile Ala His Tyr Arg Glu Gln Leu Gly Ala Ala Gly Asn Lys Ile
                405                 410                 415 

Asn Arg Pro Arg Gln Val Tyr Thr Gly Asn Glu Ser Arg Lys Leu Val
            420                 425                 430 

Pro Arg Glu Glu Arg
        435        


<210>    30
<211>    1314
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (A169V)_gltA


<400>    30
atgtttgaaa gggatatcgt ggctactgat aacaacaagg ctgtcctgca ctaccccggt         60

ggcgagttcg aaatggacat catcgaggct tctgagggta acaacggtgt tgtcctgggc        120

aagatgctgt ctgagactgg actgatcact tttgacccag gttatgtgag cactggctcc        180

accgagtcga agatcaccta catcgatggc gatgcgggaa tcctgcgtta ccgcggctat        240

gacatcgctg atctggctga gaatgccacc ttcaacgagg tttcttacct acttatcaac        300

ggtgagctac caaccccaga tgagcttcac aagtttaacg acgagattcg ccaccacacc        360

cttctggacg aggacttcaa gtcccagttc aacgtgttcc cacgcgacgc tcacccaatg        420

gcaaccttgg cttcctcggt taacattttg tctacctact accaggacca gctgaaccca        480

ctcgatgagg cacagcttga taaggtaacc gttcgcctca tggcaaaggt tccaatgctg        540

gctgcgtacg cacaccgcgc acgcaagggt gctccttaca tgtacccaga caactccctc        600

aatgcgcgtg agaacttcct gcgcatgatg ttcggttacc caaccgagcc atacgagatc        660

gacccaatca tggtcaaggc tctggacaag ctgctcatcc tgcacgctga ccacgagcag        720

aactgctcca cctccaccgt tcgtatgatc ggttccgcac aggccaacat gtttgtctcc        780

atcgctggtg gcatcaacgc tctgtccggc ccactgcacg gtggcgcaaa ccaggctgtt        840

ctggagatgc tcgaagacat caagagcaac cacggtggcg acgcaaccga gttcatgaac        900

aaggtcaaga acaaggaaga cggcgtccgc ctcatgggct tcggacaccg cgtttacaag        960

aactacgatc cacgtgcagc aatcgtcaag gagaccgcac acgagatcct cgagcacctc       1020

ggtggcgacg atcttctgga tctggcaatc aagctggaag aaattgcact ggctgatgat       1080

tacttcatct cccgcaagct ctacccgaac gtagacttct acaccggcct gatctaccgc       1140

gcaatgggct tcccaactga cttcttcacc gtattgttcg caatcggtcg tctgccagga       1200

tggatcgctc actaccgcga gcagctcggt gcagcaggca acaagatcaa ccgcccacgc       1260

caggtctaca ccggcaacga atcccgcaag ttggttcctc gcgaggagcg ctaa             1314


<210>    31
<211>    437
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_type II citrate synthase


<400>    31
Met Phe Glu Arg Asp Ile Val Ala Thr Asp Asn Asn Lys Ala Val Leu
  1               5                  10                  15 

His Tyr Pro Gly Gly Glu Phe Glu Met Asp Ile Ile Glu Ala Ser Glu
             20                  25                  30 

Gly Asn Asn Gly Val Val Leu Gly Lys Met Leu Ser Glu Thr Gly Leu
         35                  40                  45 

Ile Thr Phe Asp Pro Gly Tyr Val Ser Thr Gly Ser Thr Glu Ser Lys
     50                  55                  60 

Ile Thr Tyr Ile Asp Gly Asp Ala Gly Ile Leu Arg Tyr Arg Gly Tyr
 65                  70                  75                  80 

Asp Ile Ala Asp Leu Ala Glu Asn Ala Thr Phe Asn Glu Val Ser Tyr
                 85                  90                  95 

Leu Leu Ile Asn Gly Glu Leu Pro Thr Pro Asp Glu Leu His Lys Phe
            100                 105                 110 

Asn Asp Glu Ile Arg His His Thr Leu Leu Asp Glu Asp Phe Lys Ser
        115                 120                 125 

Gln Phe Asn Val Phe Pro Arg Asp Ala His Pro Met Ala Thr Leu Ala
    130                 135                 140 

Ser Ser Val Asn Ile Leu Ser Thr Tyr Tyr Gln Asp Gln Leu Asn Pro
145                 150                 155                 160 

Leu Asp Glu Ala Gln Leu Asp Lys Ala Thr Val Arg Leu Met Ala Lys
                165                 170                 175 

Val Pro Met Leu Ala Ala Tyr Ala His Arg Ala Arg Lys Gly Ala Pro
            180                 185                 190 

Tyr Met Tyr Pro Asp Asn Ser Leu Asn Ala Arg Glu Asn Phe Leu Arg
        195                 200                 205 

Met Met Phe Gly Tyr Pro Thr Glu Pro Tyr Glu Ile Asp Pro Ile Met
    210                 215                 220 

Val Lys Ala Leu Asp Lys Leu Leu Ile Leu His Ala Asp His Glu Gln
225                 230                 235                 240 

Asn Cys Ser Thr Ser Thr Val Arg Met Ile Gly Ser Ala Gln Ala Asn
                245                 250                 255 

Met Phe Val Ser Ile Ala Gly Gly Ile Asn Ala Leu Ser Gly Pro Leu
            260                 265                 270 

His Gly Gly Ala Asn Gln Ala Val Leu Glu Met Leu Glu Asp Ile Lys
        275                 280                 285 

Ser Asn His Gly Gly Asp Ala Thr Glu Phe Met Asn Lys Val Lys Asn
    290                 295                 300 

Lys Glu Asp Gly Val Arg Leu Met Gly Phe Gly His Arg Val Tyr Lys
305                 310                 315                 320 

Asn Tyr Asp Pro Arg Ala Ala Ile Val Lys Glu Thr Ala His Glu Ile
                325                 330                 335 

Leu Glu His Leu Gly Gly Asp Asp Leu Leu Asp Leu Ala Ile Lys Leu
            340                 345                 350 

Glu Glu Ile Ala Leu Ala Asp Asp Tyr Phe Ile Ser Arg Lys Leu Tyr
        355                 360                 365 

Pro Asn Val Asp Phe Tyr Thr Gly Leu Ile Tyr Arg Ala Met Gly Phe
    370                 375                 380 

Pro Thr Asp Phe Phe Thr Val Leu Phe Ala Ile Gly Arg Leu Pro Gly
385                 390                 395                 400 

Trp Ile Ala His Tyr Arg Glu Gln Leu Gly Ala Ala Gly Asn Lys Ile
                405                 410                 415 

Asn Arg Pro Arg Gln Val Tyr Thr Gly Asn Glu Ser Arg Lys Leu Val
            420                 425                 430 

Pro Arg Glu Glu Arg
        435        


<210>    32
<211>    1314
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_gltA


<400>    32
atgtttgaaa gggatatcgt ggctactgat aacaacaagg ctgtcctgca ctaccccggt         60

ggcgagttcg aaatggacat catcgaggct tctgagggta acaacggtgt tgtcctgggc        120

aagatgctgt ctgagactgg actgatcact tttgacccag gttatgtgag cactggctcc        180

accgagtcga agatcaccta catcgatggc gatgcgggaa tcctgcgtta ccgcggctat        240

gacatcgctg atctggctga gaatgccacc ttcaacgagg tttcttacct acttatcaac        300

ggtgagctac caaccccaga tgagcttcac aagtttaacg acgagattcg ccaccacacc        360

cttctggacg aggacttcaa gtcccagttc aacgtgttcc cacgcgacgc tcacccaatg        420

gcaaccttgg cttcctcggt taacattttg tctacctact accaggacca gctgaaccca        480

ctcgatgagg cacagcttga taaggcaacc gttcgcctca tggcaaaggt tccaatgctg        540

gctgcgtacg cacaccgcgc acgcaagggt gctccttaca tgtacccaga caactccctc        600

aatgcgcgtg agaacttcct gcgcatgatg ttcggttacc caaccgagcc atacgagatc        660

gacccaatca tggtcaaggc tctggacaag ctgctcatcc tgcacgctga ccacgagcag        720

aactgctcca cctccaccgt tcgtatgatc ggttccgcac aggccaacat gtttgtctcc        780

atcgctggtg gcatcaacgc tctgtccggc ccactgcacg gtggcgcaaa ccaggctgtt        840

ctggagatgc tcgaagacat caagagcaac cacggtggcg acgcaaccga gttcatgaac        900

aaggtcaaga acaaggaaga cggcgtccgc ctcatgggct tcggacaccg cgtttacaag        960

aactacgatc cacgtgcagc aatcgtcaag gagaccgcac acgagatcct cgagcacctc       1020

ggtggcgacg atcttctgga tctggcaatc aagctggaag aaattgcact ggctgatgat       1080

tacttcatct cccgcaagct ctacccgaac gtagacttct acaccggcct gatctaccgc       1140

gcaatgggct tcccaactga cttcttcacc gtattgttcg caatcggtcg tctgccagga       1200

tggatcgctc actaccgcga gcagctcggt gcagcaggca acaagatcaa ccgcccacgc       1260

caggtctaca ccggcaacga atcccgcaag ttggttcctc gcgaggagcg ctaa             1314


<210>    33
<211>    369
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (E294K)_TerC


<400>    33
Met Glu Val Asn Leu Ala Thr Trp Leu Ile Thr Ile Ala Val Ile Ala
  1               5                  10                  15 

Gly Phe Phe Ile Phe Asp Phe Tyr Ser His Val Arg Thr Pro His Glu
             20                  25                  30 

Pro Thr Ile Lys Glu Ser Ala Trp Trp Ser Leu Phe Tyr Val Ala Leu
         35                  40                  45 

Ala Cys Val Phe Gly Val Phe Leu Trp Phe Ala Trp Gly Glu Pro Gly
     50                  55                  60 

Asn Pro His Gln His Gly Ile Glu Phe Phe Thr Gly Tyr Val Thr Glu
 65                  70                  75                  80 

Lys Ala Leu Ser Val Asp Asn Leu Phe Ile Phe Ala Leu Ile Met Gly
                 85                  90                  95 

Ser Phe Lys Ile Pro Arg Lys Tyr Gln Gln Lys Val Leu Leu Ile Gly
            100                 105                 110 

Ile Ala Leu Ala Leu Val Phe Arg Leu Ala Phe Ile Leu Ala Gly Ala
        115                 120                 125 

Ala Val Ile Glu Ala Trp Ser Asp Val Phe Tyr Ile Phe Ser Ile Trp
    130                 135                 140 

Leu Ile Tyr Thr Ala Val Lys Leu Leu Trp Asp Glu Val Arg Asp Thr
145                 150                 155                 160 

Pro Glu Thr Asp Pro Asn Asp Met Phe Ile Ile Lys Ala Leu Arg Lys
                165                 170                 175 

Val Ile Pro Val Thr Glu Gly Tyr His Gly Asp Lys Leu Thr His Arg
            180                 185                 190 

Phe Gly Gly Lys Leu His Leu Thr Pro Leu Phe Val Ala Leu Val Ser
        195                 200                 205 

Ile Gly Met Val Asp Leu Met Phe Ala Leu Asp Ser Ile Pro Ala Ile
    210                 215                 220 

Tyr Gly Ile Thr Thr Glu Pro Tyr Ile Val Phe Thr Thr Asn Ala Phe
225                 230                 235                 240 

Ala Leu Leu Gly Leu Arg Gln Met Tyr Phe Leu Leu Asp Gly Leu Leu
                245                 250                 255 

Asp Arg Leu Val Tyr Leu Pro Tyr Gly Leu Gly Leu Ile Leu Leu Phe
            260                 265                 270 

Ile Gly Ala Lys Leu Gly Leu His Ala Leu His Glu Asn Asn Leu Pro
        275                 280                 285 

Phe Ile Asn Gly Gly Lys Asn Val Ser Val Pro Glu Val Ser Thr Val
    290                 295                 300 

Phe Ser Leu Val Phe Ile Ile Gly Val Leu Thr Ile Thr Val Ile Ala
305                 310                 315                 320 

Ser Ile Ile Lys Asn Lys Arg Asp Glu Asn Gln Gly Gly Ile Pro Pro
                325                 330                 335 

Lys Trp Asn Ala Ala Lys Tyr Glu Gly Asp Asn Trp Glu Thr Gly Glu
            340                 345                 350 

Glu Pro Glu Thr Gly Ser Ala Thr Val Thr Asp Ile Ser Ser Glu Lys
        355                 360                 365 

Lys
   


<210>    34
<211>    1110
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (E294K)_terC


<400>    34
atggaagtaa acttagccac atggctaatc actatcgcag tgattgctgg cttcttcatt         60

ttcgatttct attcccacgt ccgcacccca cacgagccca ctatcaaaga atccgcatgg        120

tggagcctct tctacgtagc cctcgcctgt gttttcggcg tgttcctctg gtttgcttgg        180

ggcgagccag gtaacccaca ccagcacggc attgagttct tcaccggtta cgtgacagag        240

aaggcgttga gtgttgataa cctcttcatc ttcgcgctga tcatgggttc tttcaagatt        300

cctcgcaagt accagcagaa ggttctgctc atcggtatcg cgctggcact ggtcttccgc        360

ctggcattca tcctcgcagg tgctgcagtt atcgaagcct ggtccgatgt cttctacatc        420

ttctccatct ggctgatcta caccgctgtg aagctcctgt gggacgaagt tcgagacacc        480

cctgagaccg acccgaacga catgttcatc attaaggcgc tgcgcaaggt cattccggtt        540

actgagggct accacggcga caagctcact caccgcttcg gaggcaagct gcacctgacc        600

ccactgttcg ttgcacttgt atccatcggc atggttgacc tgatgttcgc actggactct        660

atcccagcga tttacggcat caccacggag ccttacatcg tgttcaccac taacgcattc        720

gccctgctgg gtctgcgcca aatgtacttc ctgcttgacg gcctgcttga ccgcctggtc        780

tacctgcctt atggcttggg tcttatcctg ctgttcattg gtgcaaagct tggtctgcat        840

gcactgcacg aaaacaacct gccattcatc aacggtggta aaaacgtctc cgtacctgag        900

gtttccaccg tgttctcctt ggtcttcatc attggtgtcc tgacaatcac cgtcatcgca        960

tccatcatca agaacaaacg cgacgaaaac cagggcggta ttccaccaaa gtggaacgct       1020

gcaaagtatg agggcgacaa ctgggagacc ggtgaggagc ctgaaaccgg atccgccacc       1080

gttaccgata tctcctcaga gaagaagtaa                                        1110


<210>    35
<211>    369
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_TerC


<400>    35
Met Glu Val Asn Leu Ala Thr Trp Leu Ile Thr Ile Ala Val Ile Ala
  1               5                  10                  15 

Gly Phe Phe Ile Phe Asp Phe Tyr Ser His Val Arg Thr Pro His Glu
             20                  25                  30 

Pro Thr Ile Lys Glu Ser Ala Trp Trp Ser Leu Phe Tyr Val Ala Leu
         35                  40                  45 

Ala Cys Val Phe Gly Val Phe Leu Trp Phe Ala Trp Gly Glu Pro Gly
     50                  55                  60 

Asn Pro His Gln His Gly Ile Glu Phe Phe Thr Gly Tyr Val Thr Glu
 65                  70                  75                  80 

Lys Ala Leu Ser Val Asp Asn Leu Phe Ile Phe Ala Leu Ile Met Gly
                 85                  90                  95 

Ser Phe Lys Ile Pro Arg Lys Tyr Gln Gln Lys Val Leu Leu Ile Gly
            100                 105                 110 

Ile Ala Leu Ala Leu Val Phe Arg Leu Ala Phe Ile Leu Ala Gly Ala
        115                 120                 125 

Ala Val Ile Glu Ala Trp Ser Asp Val Phe Tyr Ile Phe Ser Ile Trp
    130                 135                 140 

Leu Ile Tyr Thr Ala Val Lys Leu Leu Trp Asp Glu Val Arg Asp Thr
145                 150                 155                 160 

Pro Glu Thr Asp Pro Asn Asp Met Phe Ile Ile Lys Ala Leu Arg Lys
                165                 170                 175 

Val Ile Pro Val Thr Glu Gly Tyr His Gly Asp Lys Leu Thr His Arg
            180                 185                 190 

Phe Gly Gly Lys Leu His Leu Thr Pro Leu Phe Val Ala Leu Val Ser
        195                 200                 205 

Ile Gly Met Val Asp Leu Met Phe Ala Leu Asp Ser Ile Pro Ala Ile
    210                 215                 220 

Tyr Gly Ile Thr Thr Glu Pro Tyr Ile Val Phe Thr Thr Asn Ala Phe
225                 230                 235                 240 

Ala Leu Leu Gly Leu Arg Gln Met Tyr Phe Leu Leu Asp Gly Leu Leu
                245                 250                 255 

Asp Arg Leu Val Tyr Leu Pro Tyr Gly Leu Gly Leu Ile Leu Leu Phe
            260                 265                 270 

Ile Gly Ala Lys Leu Gly Leu His Ala Leu His Glu Asn Asn Leu Pro
        275                 280                 285 

Phe Ile Asn Gly Gly Glu Asn Val Ser Val Pro Glu Val Ser Thr Val
    290                 295                 300 

Phe Ser Leu Val Phe Ile Ile Gly Val Leu Thr Ile Thr Val Ile Ala
305                 310                 315                 320 

Ser Ile Ile Lys Asn Lys Arg Asp Glu Asn Gln Gly Gly Ile Pro Pro
                325                 330                 335 

Lys Trp Asn Ala Ala Lys Tyr Glu Gly Asp Asn Trp Glu Thr Gly Glu
            340                 345                 350 

Glu Pro Glu Thr Gly Ser Ala Thr Val Thr Asp Ile Ser Ser Glu Lys
        355                 360                 365 

Lys
   


<210>    36
<211>    1110
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_terC


<400>    36
atggaagtaa acttagccac atggctaatc actatcgcag tgattgctgg cttcttcatt         60

ttcgatttct attcccacgt ccgcacccca cacgagccca ctatcaaaga atccgcatgg        120

tggagcctct tctacgtagc cctcgcctgt gttttcggcg tgttcctctg gtttgcttgg        180

ggcgagccag gtaacccaca ccagcacggc attgagttct tcaccggtta cgtgacagag        240

aaggcgttga gtgttgataa cctcttcatc ttcgcgctga tcatgggttc tttcaagatt        300

cctcgcaagt accagcagaa ggttctgctc atcggtatcg cgctggcact ggtcttccgc        360

ctggcattca tcctcgcagg tgctgcagtt atcgaagcct ggtccgatgt cttctacatc        420

ttctccatct ggctgatcta caccgctgtg aagctcctgt gggacgaagt tcgagacacc        480

cctgagaccg acccgaacga catgttcatc attaaggcgc tgcgcaaggt cattccggtt        540

actgagggct accacggcga caagctcact caccgcttcg gaggcaagct gcacctgacc        600

ccactgttcg ttgcacttgt atccatcggc atggttgacc tgatgttcgc actggactct        660

atcccagcga tttacggcat caccacggag ccttacatcg tgttcaccac taacgcattc        720

gccctgctgg gtctgcgcca aatgtacttc ctgcttgacg gcctgcttga ccgcctggtc        780

tacctgcctt atggcttggg tcttatcctg ctgttcattg gtgcaaagct tggtctgcat        840

gcactgcacg aaaacaacct gccattcatc aacggtggtg aaaacgtctc cgtacctgag        900

gtttccaccg tgttctcctt ggtcttcatc attggtgtcc tgacaatcac cgtcatcgca        960

tccatcatca agaacaaacg cgacgaaaac cagggcggta ttccaccaaa gtggaacgct       1020

gcaaagtatg agggcgacaa ctgggagacc ggtgaggagc ctgaaaccgg atccgccacc       1080

gttaccgata tctcctcaga gaagaagtaa                                        1110


<210>    37
<211>    465
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (P358S)_mycothione reductase


<400>    37
Met Ser Glu Gln Pro Ala Ser Ile Lys His Tyr Asp Leu Ile Ile Ile
  1               5                  10                  15 

Gly Thr Gly Ser Gly Asn Ser Ile Pro Gly Pro Glu Phe Asp Asp Lys
             20                  25                  30 

Ser Ile Ala Ile Val Glu Lys Gly Ala Phe Gly Gly Thr Cys Leu Asn
         35                  40                  45 

Val Gly Cys Ile Pro Thr Lys Met Tyr Val Tyr Ala Ala Asp Ile Ala
     50                  55                  60 

Gln Glu Ile Gln Glu Ser Ala Arg Leu Gly Ile Asp Ala Thr Val Asn
 65                  70                  75                  80 

Ser Val Asp Trp Pro Ser Ile Val Ser Arg Val Phe Asp Lys Arg Ile
                 85                  90                  95 

Asp Leu Ile Ala Gln Gly Gly Glu Ala Tyr Arg Arg Gly Pro Glu Thr
            100                 105                 110 

Pro Asn Ile Asp Val Tyr Asp Met His Ala Ser Phe Val Asp Ser Lys
        115                 120                 125 

Thr Ile Ser Thr Gly Ile Ala Gly Gln Glu Gln Leu Ile Ser Gly Thr
    130                 135                 140 

Asp Ile Val Ile Ala Thr Gly Ser Arg Pro Tyr Ile Pro Glu Ala Ile
145                 150                 155                 160 

Ala Glu Ser Gly Ala Arg Tyr Tyr Thr Asn Glu Asp Ile Met Arg Leu
                165                 170                 175 

Ala Gln Gln Pro Glu Ser Leu Val Ile Val Gly Gly Gly Phe Ile Ala
            180                 185                 190 

Leu Glu Phe Ala His Val Phe Glu Ala Leu Gly Thr Lys Val Thr Ile
        195                 200                 205 

Leu Asn Arg Ser Asp Val Leu Leu Arg Glu Ala Asp Ala Asp Ile Ser
    210                 215                 220 

Ala Lys Ile Leu Glu Leu Ser Lys Lys Arg Phe Asp Val Arg Leu Ser
225                 230                 235                 240 

Thr Ala Val Thr Ala Val His Asn Lys Ala Asp Gly Gly Val Lys Ile
                245                 250                 255 

Ser Thr Asp Thr Gly Asp Asp Ile Glu Ala Asp Ile Leu Leu Val Ala
            260                 265                 270 

Thr Gly Arg Thr Pro Asn Gly Asn Gln Met Asn Leu Asp Ala Ala Gly
        275                 280                 285 

Ile Glu Met Asn Gly Arg Ser Ile Lys Val Asp Glu Phe Gly Arg Thr
    290                 295                 300 

Ser Val Glu Gly Val Trp Ala Leu Gly Asp Val Ser Ser Pro Tyr Lys
305                 310                 315                 320 

Leu Lys His Val Ala Asn Ala Glu Met Arg Ala Ile Lys His Asn Leu
                325                 330                 335 

Ala Asn Pro Asn Asp Leu Gln Lys Met Pro His Asp Phe Val Pro Ser
            340                 345                 350 

Ala Val Phe Thr Asn Ser Gln Ile Ser Gln Val Gly Met Thr Glu Gln
        355                 360                 365 

Glu Ala Arg Glu Ala Gly Leu Asp Ile Thr Val Lys Ile Gln Asn Tyr
    370                 375                 380 

Ser Asp Val Ala Tyr Gly Trp Ala Met Glu Asp Lys Asp Gly Phe Val
385                 390                 395                 400 

Lys Leu Ile Ala Asp Lys Asp Thr Gly Lys Leu Val Gly Ala His Ile
                405                 410                 415 

Ile Gly Ala Gln Ala Ser Thr Leu Ile Gln Gln Leu Ile Thr Val Met
            420                 425                 430 

Ala Phe Gly Ile Asp Ala Arg Glu Ala Ala Thr Lys Gln Tyr Trp Ile
        435                 440                 445 

His Pro Ala Leu Pro Glu Val Ile Glu Asn Ala Leu Leu Gly Leu Glu
    450                 455                 460 

Phe
465


<210>    38
<211>    1398
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (P358S)_mtr


<400>    38
atgtctgagc agccagcttc cattaagcat tatgacctca tcatcattgg taccggctct         60

ggaaactcca ttcctggacc agagtttgat gataaatcaa ttgccatcgt ggaaaagggt        120

gctttcggcg gaacttgcct caatgtgggc tgcatcccta ccaagatgta cgtttacgct        180

gcggatatcg ctcaagaaat tcaggagtct gctcgcctgg gtatcgatgc gacggtcaac        240

agcgtggatt ggccttccat cgtcagccgc gttttcgaca agcgcatcga cctcatcgcg        300

caaggcggcg aggcttatcg acgtggcccc gaaactccaa acatcgatgt gtatgacatg        360

cacgcatcgt ttgttgattc caagacaatc tccactggta ttgccggcca agaacagctg        420

atcagcggta ctgacattgt aatcgcaacc ggctcccgcc cttacatccc tgaagctatt        480

gcagagtccg gcgcacgcta ctacaccaac gaagacatca tgcgcctggc acagcagcct        540

gaatctttgg tgattgttgg tggcggtttc atcgctttgg aatttgctca cgtttttgaa        600

gcgcttggca ccaaggtcac catcctcaac cgctctgacg tgctgctgcg cgaggcagat        660

gcagacatct ccgcgaaaat cctcgagctt tccaaaaagc gtttcgacgt ccgcctcagc        720

actgcggtca ccgcagtaca caacaaggcc gacggcggcg tgaagatctc caccgacacc        780

ggcgacgaca tcgaggcaga tattttgctc gttgccactg gtcgcacccc taacggcaac        840

caaatgaact tggacgccgc aggcatcgag atgaacggtc gttccatcaa ggttgatgaa        900

ttcggtcgca ccagtgttga aggcgtgtgg gcgcttggcg atgtctcctc cccttacaag        960

ctcaagcacg tagccaatgc ggaaatgcga gcaatcaagc acaaccttgc caaccctaat       1020

gacctgcaga agatgccaca tgatttcgtg ccatcagctg ttttcaccaa ctctcagatc       1080

tcgcaggtcg gcatgactga gcaggaggcg cgtgaagctg gcctcgacat cactgtgaag       1140

atccagaact actctgatgt ggcttatggc tgggccatgg aagataagga tggattcgtt       1200

aagctcattg ccgataagga caccggcaag ttggtcggcg cgcacatcat tggtgctcaa       1260

gcctcaacac tgatccagca actgatcact gtcatggcat ttggaatcga tgcacgagaa       1320

gctgcaacca agcagtactg gattcaccct gctcttccag aagtcatcga aaacgctctt       1380

ctggggctag agttttag                                                     1398


<210>    39
<211>    465
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_mycothione reductase


<400>    39
Met Ser Glu Gln Pro Ala Ser Ile Lys His Tyr Asp Leu Ile Ile Ile
  1               5                  10                  15 

Gly Thr Gly Ser Gly Asn Ser Ile Pro Gly Pro Glu Phe Asp Asp Lys
             20                  25                  30 

Ser Ile Ala Ile Val Glu Lys Gly Ala Phe Gly Gly Thr Cys Leu Asn
         35                  40                  45 

Val Gly Cys Ile Pro Thr Lys Met Tyr Val Tyr Ala Ala Asp Ile Ala
     50                  55                  60 

Gln Glu Ile Gln Glu Ser Ala Arg Leu Gly Ile Asp Ala Thr Val Asn
 65                  70                  75                  80 

Ser Val Asp Trp Pro Ser Ile Val Ser Arg Val Phe Asp Lys Arg Ile
                 85                  90                  95 

Asp Leu Ile Ala Gln Gly Gly Glu Ala Tyr Arg Arg Gly Pro Glu Thr
            100                 105                 110 

Pro Asn Ile Asp Val Tyr Asp Met His Ala Ser Phe Val Asp Ser Lys
        115                 120                 125 

Thr Ile Ser Thr Gly Ile Ala Gly Gln Glu Gln Leu Ile Ser Gly Thr
    130                 135                 140 

Asp Ile Val Ile Ala Thr Gly Ser Arg Pro Tyr Ile Pro Glu Ala Ile
145                 150                 155                 160 

Ala Glu Ser Gly Ala Arg Tyr Tyr Thr Asn Glu Asp Ile Met Arg Leu
                165                 170                 175 

Ala Gln Gln Pro Glu Ser Leu Val Ile Val Gly Gly Gly Phe Ile Ala
            180                 185                 190 

Leu Glu Phe Ala His Val Phe Glu Ala Leu Gly Thr Lys Val Thr Ile
        195                 200                 205 

Leu Asn Arg Ser Asp Val Leu Leu Arg Glu Ala Asp Ala Asp Ile Ser
    210                 215                 220 

Ala Lys Ile Leu Glu Leu Ser Lys Lys Arg Phe Asp Val Arg Leu Ser
225                 230                 235                 240 

Thr Ala Val Thr Ala Val His Asn Lys Ala Asp Gly Gly Val Lys Ile
                245                 250                 255 

Ser Thr Asp Thr Gly Asp Asp Ile Glu Ala Asp Ile Leu Leu Val Ala
            260                 265                 270 

Thr Gly Arg Thr Pro Asn Gly Asn Gln Met Asn Leu Asp Ala Ala Gly
        275                 280                 285 

Ile Glu Met Asn Gly Arg Ser Ile Lys Val Asp Glu Phe Gly Arg Thr
    290                 295                 300 

Ser Val Glu Gly Val Trp Ala Leu Gly Asp Val Ser Ser Pro Tyr Lys
305                 310                 315                 320 

Leu Lys His Val Ala Asn Ala Glu Met Arg Ala Ile Lys His Asn Leu
                325                 330                 335 

Ala Asn Pro Asn Asp Leu Gln Lys Met Pro His Asp Phe Val Pro Ser
            340                 345                 350 

Ala Val Phe Thr Asn Pro Gln Ile Ser Gln Val Gly Met Thr Glu Gln
        355                 360                 365 

Glu Ala Arg Glu Ala Gly Leu Asp Ile Thr Val Lys Ile Gln Asn Tyr
    370                 375                 380 

Ser Asp Val Ala Tyr Gly Trp Ala Met Glu Asp Lys Asp Gly Phe Val
385                 390                 395                 400 

Lys Leu Ile Ala Asp Lys Asp Thr Gly Lys Leu Val Gly Ala His Ile
                405                 410                 415 

Ile Gly Ala Gln Ala Ser Thr Leu Ile Gln Gln Leu Ile Thr Val Met
            420                 425                 430 

Ala Phe Gly Ile Asp Ala Arg Glu Ala Ala Thr Lys Gln Tyr Trp Ile
        435                 440                 445 

His Pro Ala Leu Pro Glu Val Ile Glu Asn Ala Leu Leu Gly Leu Glu
    450                 455                 460 

Phe
465


<210>    40
<211>    1398
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_mtr


<400>    40
atgtctgagc agccagcttc cattaagcat tatgacctca tcatcattgg taccggctct         60

ggaaactcca ttcctggacc agagtttgat gataaatcaa ttgccatcgt ggaaaagggt        120

gctttcggcg gaacttgcct caatgtgggc tgcatcccta ccaagatgta cgtttacgct        180

gcggatatcg ctcaagaaat tcaggagtct gctcgcctgg gtatcgatgc gacggtcaac        240

agcgtggatt ggccttccat cgtcagccgc gttttcgaca agcgcatcga cctcatcgcg        300

caaggcggcg aggcttatcg acgtggcccc gaaactccaa acatcgatgt gtatgacatg        360

cacgcatcgt ttgttgattc caagacaatc tccactggta ttgccggcca agaacagctg        420

atcagcggta ctgacattgt aatcgcaacc ggctcccgcc cttacatccc tgaagctatt        480

gcagagtccg gcgcacgcta ctacaccaac gaagacatca tgcgcctggc acagcagcct        540

gaatctttgg tgattgttgg tggcggtttc atcgctttgg aatttgctca cgtttttgaa        600

gcgcttggca ccaaggtcac catcctcaac cgctctgacg tgctgctgcg cgaggcagat        660

gcagacatct ccgcgaaaat cctcgagctt tccaaaaagc gtttcgacgt ccgcctcagc        720

actgcggtca ccgcagtaca caacaaggcc gacggcggcg tgaagatctc caccgacacc        780

ggcgacgaca tcgaggcaga tattttgctc gttgccactg gtcgcacccc taacggcaac        840

caaatgaact tggacgccgc aggcatcgag atgaacggtc gttccatcaa ggttgatgaa        900

ttcggtcgca ccagtgttga aggcgtgtgg gcgcttggcg atgtctcctc cccttacaag        960

ctcaagcacg tagccaatgc ggaaatgcga gcaatcaagc acaaccttgc caaccctaat       1020

gacctgcaga agatgccaca tgatttcgtg ccatcagctg ttttcaccaa ccctcagatc       1080

tcgcaggtcg gcatgactga gcaggaggcg cgtgaagctg gcctcgacat cactgtgaag       1140

atccagaact actctgatgt ggcttatggc tgggccatgg aagataagga tggattcgtt       1200

aagctcattg ccgataagga caccggcaag ttggtcggcg cgcacatcat tggtgctcaa       1260

gcctcaacac tgatccagca actgatcact gtcatggcat ttggaatcga tgcacgagaa       1320

gctgcaacca agcagtactg gattcaccct gctcttccag aagtcatcga aaacgctctt       1380

ctggggctag agttttag                                                     1398


<210>    41
<211>    205
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (G130D)_Co/Zn/Cd efflux system component


<400>    41
Met Ser Glu Ala Phe Asp Ala Thr Lys Val Arg Lys Ala Val Leu Thr
  1               5                  10                  15 

Val Ala Leu Leu Asn Phe Ala Tyr Phe Phe Val Glu Phe Phe Ile Ala
             20                  25                  30 

Leu Ser Ala Gly Ser Val Ser Leu Leu Ala Asp Ser Val Asp Phe Leu
         35                  40                  45 

Glu Asp Thr Ser Ile Asn Leu Leu Ile Phe Ile Ala Leu Gly Trp Pro
     50                  55                  60 

Leu Ala Arg Arg Ala Val Met Gly Lys Leu Met Ala Ile Val Ile Leu
 65                  70                  75                  80 

Ala Pro Ala Ala Phe Ala Ala Trp Ala Ala Ile Gln Arg Phe Ser Ala
                 85                  90                  95 

Pro Gln Ala Pro Glu Val Phe Pro Ile Ile Val Ala Ser Leu Gly Ala
            100                 105                 110 

Val Val Ile Asn Gly Ala Ser Ala Ile Ile Ile Ser Arg Val Arg Gln
        115                 120                 125 

His Asp Gly Ser Leu Gly Gln Ala Ala Phe Leu Ser Ala Arg Asn Asp
    130                 135                 140 

Val Leu Ile Asn Ile Ala Ile Ile Met Met Ala Leu Ile Thr Ala Trp
145                 150                 155                 160 

Thr Thr Ser Gly Trp Pro Asp Leu Ile Leu Gly Cys Phe Ile Ile Leu
                165                 170                 175 

Leu Ala Leu His Ala Ala His Glu Val Trp Glu Val Ser Glu Glu Glu
            180                 185                 190 

Arg Leu Ala Ser Lys Ala Leu Ala Gly Glu Ala Ile Asp
        195                 200                 205


<210>    42
<211>    618
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (G130D)_N1992


<400>    42
atgagcgaag cttttgatgc aaccaaagtg cgcaaagctg tgctcaccgt cgcgctgctt         60

aacttcgctt atttctttgt agaattcttt attgcattaa gcgcaggctc cgtttctcta        120

ctggctgaca gtgtcgattt tcttgaagac acctccatca acctgctcat tttcattgcc        180

ctaggatggc cgttggcgag gcgcgcagtg atgggcaaac ttatggcgat tgtgattctt        240

gcacctgctg cttttgctgc gtgggcagcg attcaacggt tttccgcacc gcaagcgccc        300

gaagtgtttc cgatcatcgt cgcttctctg ggcgccgtcg tgatcaacgg cgcgagtgcc        360

atcattattt ctcgagtgcg acaacatgat ggctcgcttg gccaagctgc cttcctatcc        420

gcccgaaatg acgtcctgat caacattgcc atcatcatga tggccttaat taccgcatgg        480

acgacgtctg gatggccaga tttgatccta ggttgtttca tcattctgct cgcactgcac        540

gccgctcacg aggtgtggga agtcagtgag gaagaacgcc tcgcctccaa agcccttgct        600

ggggaagcca tcgattag                                                      618


<210>    43
<211>    205
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_Co/Zn/Cd efflux system component


<400>    43
Met Ser Glu Ala Phe Asp Ala Thr Lys Val Arg Lys Ala Val Leu Thr
  1               5                  10                  15 

Val Ala Leu Leu Asn Phe Ala Tyr Phe Phe Val Glu Phe Phe Ile Ala
             20                  25                  30 

Leu Ser Ala Gly Ser Val Ser Leu Leu Ala Asp Ser Val Asp Phe Leu
         35                  40                  45 

Glu Asp Thr Ser Ile Asn Leu Leu Ile Phe Ile Ala Leu Gly Trp Pro
     50                  55                  60 

Leu Ala Arg Arg Ala Val Met Gly Lys Leu Met Ala Ile Val Ile Leu
 65                  70                  75                  80 

Ala Pro Ala Ala Phe Ala Ala Trp Ala Ala Ile Gln Arg Phe Ser Ala
                 85                  90                  95 

Pro Gln Ala Pro Glu Val Phe Pro Ile Ile Val Ala Ser Leu Gly Ala
            100                 105                 110 

Val Val Ile Asn Gly Ala Ser Ala Ile Ile Ile Ser Arg Val Arg Gln
        115                 120                 125 

His Gly Gly Ser Leu Gly Gln Ala Ala Phe Leu Ser Ala Arg Asn Asp
    130                 135                 140 

Val Leu Ile Asn Ile Ala Ile Ile Met Met Ala Leu Ile Thr Ala Trp
145                 150                 155                 160 

Thr Thr Ser Gly Trp Pro Asp Leu Ile Leu Gly Cys Phe Ile Ile Leu
                165                 170                 175 

Leu Ala Leu His Ala Ala His Glu Val Trp Glu Val Ser Glu Glu Glu
            180                 185                 190 

Arg Leu Ala Ser Lys Ala Leu Ala Gly Glu Ala Ile Asp
        195                 200                 205


<210>    44
<211>    618
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_N1992


<400>    44
atgagcgaag cttttgatgc aaccaaagtg cgcaaagctg tgctcaccgt cgcgctgctt         60

aacttcgctt atttctttgt agaattcttt attgcattaa gcgcaggctc cgtttctcta        120

ctggctgaca gtgtcgattt tcttgaagac acctccatca acctgctcat tttcattgcc        180

ctaggatggc cgttggcgag gcgcgcagtg atgggcaaac ttatggcgat tgtgattctt        240

gcacctgctg cttttgctgc gtgggcagcg attcaacggt tttccgcacc gcaagcgccc        300

gaagtgtttc cgatcatcgt cgcttctctg ggcgccgtcg tgatcaacgg cgcgagtgcc        360

atcattattt ctcgagtgcg acaacatggt ggctcgcttg gccaagctgc cttcctatcc        420

gcccgaaatg acgtcctgat caacattgcc atcatcatga tggccttaat taccgcatgg        480

acgacgtctg gatggccaga tttgatccta ggttgtttca tcattctgct cgcactgcac        540

gccgctcacg aggtgtggga agtcagtgag gaagaacgcc tcgcctccaa agcccttgct        600

ggggaagcca tcgattag                                                      618


<210>    45
<211>    466
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (G382C)_3-deoxy-D-arabinoheptulosonate-7-phosphate synthase


<400>    45
Met Asn Arg Gly Val Ser Trp Thr Val Asp Ile Pro Lys Glu Val Leu
  1               5                  10                  15 

Pro Asp Leu Pro Pro Leu Pro Glu Gly Met Gln Gln Gln Phe Glu Asp
             20                  25                  30 

Thr Ile Ser Arg Asp Ala Lys Gln Gln Pro Thr Trp Asp Arg Ala Gln
         35                  40                  45 

Ala Glu Asn Val Arg Lys Ile Leu Glu Ser Val Pro Pro Ile Val Val
     50                  55                  60 

Ala Pro Glu Val Leu Glu Leu Lys Gln Lys Leu Ala Asp Val Ala Asn
 65                  70                  75                  80 

Gly Lys Ala Phe Leu Leu Gln Gly Gly Asp Cys Ala Glu Thr Phe Glu
                 85                  90                  95 

Ser Asn Thr Glu Pro His Ile Arg Ala Asn Val Lys Thr Leu Leu Gln
            100                 105                 110 

Met Ala Val Val Leu Thr Tyr Gly Ala Ser Thr Pro Val Ile Lys Met
        115                 120                 125 

Ala Arg Ile Ala Gly Gln Tyr Ala Lys Pro Arg Ser Ser Asp Leu Asp
    130                 135                 140 

Gly Asn Gly Leu Pro Asn Tyr Arg Gly Asp Ile Val Asn Gly Val Glu
145                 150                 155                 160 

Ala Thr Pro Glu Ala Arg Arg His Asp Pro Ala Arg Met Ile Arg Ala
                165                 170                 175 

Tyr Ala Asn Ala Ser Ala Ala Met Asn Leu Val Arg Ala Leu Thr Ser
            180                 185                 190 

Ser Gly Thr Ala Asp Leu Tyr Arg Leu Ser Glu Trp Asn Arg Glu Phe
        195                 200                 205 

Val Ala Asn Ser Pro Ala Gly Ala Arg Tyr Glu Ala Leu Ala Arg Glu
    210                 215                 220 

Ile Asp Ser Gly Leu Arg Phe Met Glu Ala Cys Gly Val Ser Asp Glu
225                 230                 235                 240 

Ser Leu Arg Ala Ala Asp Ile Tyr Cys Ser His Glu Ala Leu Leu Val
                245                 250                 255 

Asp Tyr Glu Arg Ser Met Leu Arg Leu Ala Thr Asp Glu Glu Gly Asn
            260                 265                 270 

Glu Glu Leu Tyr Asp Leu Ser Ala His Gln Leu Trp Ile Gly Glu Arg
        275                 280                 285 

Thr Arg Gly Met Asp Asp Phe His Val Asn Phe Ala Ser Met Ile Ser
    290                 295                 300 

Asn Pro Ile Gly Ile Lys Ile Gly Pro Gly Ile Thr Pro Glu Glu Ala
305                 310                 315                 320 

Val Ala Tyr Ala Asp Lys Leu Asp Pro Asn Phe Glu Pro Gly Arg Leu
                325                 330                 335 

Thr Ile Val Ala Arg Met Gly His Asp Lys Val Arg Ser Val Leu Pro
            340                 345                 350 

Gly Val Ile Gln Ala Val Glu Ala Ser Gly His Lys Val Ile Trp Gln
        355                 360                 365 

Ser Asp Pro Met His Gly Asn Thr Phe Thr Ala Ser Asn Cys Tyr Lys
    370                 375                 380 

Thr Arg His Phe Asp Lys Val Ile Asp Glu Val Gln Gly Phe Phe Glu
385                 390                 395                 400 

Val His Arg Ala Leu Gly Thr His Pro Gly Gly Ile His Ile Glu Phe
                405                 410                 415 

Thr Gly Glu Asp Val Thr Glu Cys Leu Gly Gly Ala Glu Asp Ile Thr
            420                 425                 430 

Asp Val Asp Leu Pro Gly Arg Tyr Glu Ser Ala Cys Asp Pro Arg Leu
        435                 440                 445 

Asn Thr Gln Gln Ser Leu Glu Leu Ala Phe Leu Val Ala Glu Met Leu
    450                 455                 460 

Arg Asn
465    


<210>    46
<211>    1401
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (G382C)_aroG


<400>    46
atgaataggg gtgtgagttg gacagttgat atccctaaag aagttctccc tgatttgcca         60

ccattgccag aaggcatgca gcagcagttc gaggacacca tttcccgtga cgctaagcag        120

caacctacgt gggatcgtgc acaggcagaa aacgtgcgca agatccttga gtcggttcct        180

ccaatcgttg ttgcccctga ggtacttgag ctgaagcaga agcttgctga tgttgccaac        240

ggtaaggcct tcctcttgca gggtggtgac tgtgcggaaa ctttcgagtc aaacactgag        300

ccgcacattc gcgccaacgt aaagactctg ctgcagatgg cagttgtttt gacctacggt        360

gcatccactc ctgtgatcaa gatggctcgt attgctggtc agtacgcaaa gcctcgctct        420

tctgatctgg atggaaatgg tctgccaaac taccgtggcg atatcgtcaa cggtgtggag        480

gcaaccccag aggctcgtcg ccacgatcct gcccgcatga tccgtgctta cgctaacgct        540

tctgctgcga tgaacttggt gcgcgcgctc accagctctg gcaccgctga tctttaccgt        600

ctcagcgagt ggaaccgcga gttcgttgcg aactccccag ctggtgcacg ctacgaggct        660

cttgctcgtg agatcgactc cggtctgcgc ttcatggaag catgtggcgt gtccgatgag        720

tccctgcgtg ctgcagatat ctactgctcc cacgaggctt tgctggtgga ttacgagcgt        780

tccatgctgc gtcttgcaac cgatgaggaa ggcaacgagg aactttacga tctttcagct        840

caccagctgt ggatcggcga gcgcacccgt ggcatggatg atttccatgt gaacttcgca        900

tccatgatct ctaacccaat cggcatcaag attggtcctg gtatcacccc tgaagaggct        960

gttgcatacg ctgacaagct cgatccgaac ttcgagcctg gccgtttgac catcgttgct       1020

cgcatgggcc acgacaaggt tcgctccgta cttcctggtg ttatccaggc tgttgaggca       1080

tccggacaca aggttatttg gcagtccgat ccgatgcacg gcaacacttt caccgcatcc       1140

aattgctaca agacccgtca cttcgacaag gttatcgatg aggtccaggg cttcttcgag       1200

gtccaccgcg cattgggcac ccacccaggc ggaatccaca ttgagttcac tggtgaagat       1260

gtcaccgagt gcctcggtgg cgctgaagac atcaccgatg ttgatctgcc aggccgctac       1320

gagtccgcat gcgatcctcg cctgaacact cagcagtctt tggagttggc tttcctcgtt       1380

gcagaaatgc tgcgtaacta a                                                 1401


<210>    47
<211>    466
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_3-deoxy-D-arabinoheptulosonate-7-phosphate synthase


<400>    47
Met Asn Arg Gly Val Ser Trp Thr Val Asp Ile Pro Lys Glu Val Leu
  1               5                  10                  15 

Pro Asp Leu Pro Pro Leu Pro Glu Gly Met Gln Gln Gln Phe Glu Asp
             20                  25                  30 

Thr Ile Ser Arg Asp Ala Lys Gln Gln Pro Thr Trp Asp Arg Ala Gln
         35                  40                  45 

Ala Glu Asn Val Arg Lys Ile Leu Glu Ser Val Pro Pro Ile Val Val
     50                  55                  60 

Ala Pro Glu Val Leu Glu Leu Lys Gln Lys Leu Ala Asp Val Ala Asn
 65                  70                  75                  80 

Gly Lys Ala Phe Leu Leu Gln Gly Gly Asp Cys Ala Glu Thr Phe Glu
                 85                  90                  95 

Ser Asn Thr Glu Pro His Ile Arg Ala Asn Val Lys Thr Leu Leu Gln
            100                 105                 110 

Met Ala Val Val Leu Thr Tyr Gly Ala Ser Thr Pro Val Ile Lys Met
        115                 120                 125 

Ala Arg Ile Ala Gly Gln Tyr Ala Lys Pro Arg Ser Ser Asp Leu Asp
    130                 135                 140 

Gly Asn Gly Leu Pro Asn Tyr Arg Gly Asp Ile Val Asn Gly Val Glu
145                 150                 155                 160 

Ala Thr Pro Glu Ala Arg Arg His Asp Pro Ala Arg Met Ile Arg Ala
                165                 170                 175 

Tyr Ala Asn Ala Ser Ala Ala Met Asn Leu Val Arg Ala Leu Thr Ser
            180                 185                 190 

Ser Gly Thr Ala Asp Leu Tyr Arg Leu Ser Glu Trp Asn Arg Glu Phe
        195                 200                 205 

Val Ala Asn Ser Pro Ala Gly Ala Arg Tyr Glu Ala Leu Ala Arg Glu
    210                 215                 220 

Ile Asp Ser Gly Leu Arg Phe Met Glu Ala Cys Gly Val Ser Asp Glu
225                 230                 235                 240 

Ser Leu Arg Ala Ala Asp Ile Tyr Cys Ser His Glu Ala Leu Leu Val
                245                 250                 255 

Asp Tyr Glu Arg Ser Met Leu Arg Leu Ala Thr Asp Glu Glu Gly Asn
            260                 265                 270 

Glu Glu Leu Tyr Asp Leu Ser Ala His Gln Leu Trp Ile Gly Glu Arg
        275                 280                 285 

Thr Arg Gly Met Asp Asp Phe His Val Asn Phe Ala Ser Met Ile Ser
    290                 295                 300 

Asn Pro Ile Gly Ile Lys Ile Gly Pro Gly Ile Thr Pro Glu Glu Ala
305                 310                 315                 320 

Val Ala Tyr Ala Asp Lys Leu Asp Pro Asn Phe Glu Pro Gly Arg Leu
                325                 330                 335 

Thr Ile Val Ala Arg Met Gly His Asp Lys Val Arg Ser Val Leu Pro
            340                 345                 350 

Gly Val Ile Gln Ala Val Glu Ala Ser Gly His Lys Val Ile Trp Gln
        355                 360                 365 

Ser Asp Pro Met His Gly Asn Thr Phe Thr Ala Ser Asn Gly Tyr Lys
    370                 375                 380 

Thr Arg His Phe Asp Lys Val Ile Asp Glu Val Gln Gly Phe Phe Glu
385                 390                 395                 400 

Val His Arg Ala Leu Gly Thr His Pro Gly Gly Ile His Ile Glu Phe
                405                 410                 415 

Thr Gly Glu Asp Val Thr Glu Cys Leu Gly Gly Ala Glu Asp Ile Thr
            420                 425                 430 

Asp Val Asp Leu Pro Gly Arg Tyr Glu Ser Ala Cys Asp Pro Arg Leu
        435                 440                 445 

Asn Thr Gln Gln Ser Leu Glu Leu Ala Phe Leu Val Ala Glu Met Leu
    450                 455                 460 

Arg Asn
465    


<210>    48
<211>    1401
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_aroG


<400>    48
atgaataggg gtgtgagttg gacagttgat atccctaaag aagttctccc tgatttgcca         60

ccattgccag aaggcatgca gcagcagttc gaggacacca tttcccgtga cgctaagcag        120

caacctacgt gggatcgtgc acaggcagaa aacgtgcgca agatccttga gtcggttcct        180

ccaatcgttg ttgcccctga ggtacttgag ctgaagcaga agcttgctga tgttgccaac        240

ggtaaggcct tcctcttgca gggtggtgac tgtgcggaaa ctttcgagtc aaacactgag        300

ccgcacattc gcgccaacgt aaagactctg ctgcagatgg cagttgtttt gacctacggt        360

gcatccactc ctgtgatcaa gatggctcgt attgctggtc agtacgcaaa gcctcgctct        420

tctgatctgg atggaaatgg tctgccaaac taccgtggcg atatcgtcaa cggtgtggag        480

gcaaccccag aggctcgtcg ccacgatcct gcccgcatga tccgtgctta cgctaacgct        540

tctgctgcga tgaacttggt gcgcgcgctc accagctctg gcaccgctga tctttaccgt        600

ctcagcgagt ggaaccgcga gttcgttgcg aactccccag ctggtgcacg ctacgaggct        660

cttgctcgtg agatcgactc cggtctgcgc ttcatggaag catgtggcgt gtccgatgag        720

tccctgcgtg ctgcagatat ctactgctcc cacgaggctt tgctggtgga ttacgagcgt        780

tccatgctgc gtcttgcaac cgatgaggaa ggcaacgagg aactttacga tctttcagct        840

caccagctgt ggatcggcga gcgcacccgt ggcatggatg atttccatgt gaacttcgca        900

tccatgatct ctaacccaat cggcatcaag attggtcctg gtatcacccc tgaagaggct        960

gttgcatacg ctgacaagct cgatccgaac ttcgagcctg gccgtttgac catcgttgct       1020

cgcatgggcc acgacaaggt tcgctccgta cttcctggtg ttatccaggc tgttgaggca       1080

tccggacaca aggttatttg gcagtccgat ccgatgcacg gcaacacttt caccgcatcc       1140

aatggctaca agacccgtca cttcgacaag gttatcgatg aggtccaggg cttcttcgag       1200

gtccaccgcg cattgggcac ccacccaggc ggaatccaca ttgagttcac tggtgaagat       1260

gtcaccgagt gcctcggtgg cgctgaagac atcaccgatg ttgatctgcc aggccgctac       1320

gagtccgcat gcgatcctcg cctgaacact cagcagtctt tggagttggc tttcctcgtt       1380

gcagaaatgc tgcgtaacta a                                                 1401


<210>    49
<211>    367
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (P209L)_N-succinyldiaminopimelate aminotransferase


<400>    49
Met Thr Ser Arg Thr Pro Leu Val Ser Val Leu Pro Asp Phe Pro Trp
  1               5                  10                  15 

Asp Ser Leu Ala Ser Ala Lys Ala Lys Ala Ala Ser His Pro Asp Gly
             20                  25                  30 

Ile Val Asn Leu Ser Val Gly Thr Pro Val Asp Pro Val Ala Pro Ser
         35                  40                  45 

Ile Gln Ile Ala Leu Ala Glu Ala Ala Gly Phe Ser Gly Tyr Pro Gln
     50                  55                  60 

Thr Ile Gly Thr Pro Glu Leu Arg Ala Ala Ile Arg Gly Ala Leu Glu
 65                  70                  75                  80 

Arg Arg Tyr Asn Met Thr Lys Leu Val Asp Ala Ser Leu Leu Pro Val
                 85                  90                  95 

Val Gly Thr Lys Glu Ala Ile Ala Leu Leu Pro Phe Ala Leu Gly Ile
            100                 105                 110 

Ser Gly Thr Val Val Ile Pro Glu Ile Ala Tyr Pro Thr Tyr Glu Val
        115                 120                 125 

Ala Val Val Ala Ala Gly Cys Thr Val Leu Arg Ser Asp Ser Leu Phe
    130                 135                 140 

Lys Leu Gly Pro Gln Ile Pro Ser Met Met Phe Ile Asn Ser Pro Ser
145                 150                 155                 160 

Asn Pro Thr Gly Lys Val Leu Gly Ile Pro His Leu Arg Lys Val Val
                165                 170                 175 

Lys Trp Ala Gln Glu Asn Asn Val Ile Leu Ala Ala Asp Glu Cys Tyr
            180                 185                 190 

Leu Gly Leu Gly Trp Asp Asp Glu Asn Pro Pro Ile Ser Ile Leu Asp
        195                 200                 205 

Leu Arg Val Cys Asp Gly Asp His Thr Asn Leu Ile Ala Ile His Ser
    210                 215                 220 

Leu Ser Lys Thr Ser Asn Leu Ala Ser Tyr Arg Ala Gly Tyr Leu Val
225                 230                 235                 240 

Gly Asp Pro Ala Leu Ile Gly Glu Leu Thr Glu Val Arg Lys Asn Leu
                245                 250                 255 

Gly Leu Met Val Pro Phe Pro Ile Gln Gln Ala Met Ile Ala Ala Leu
            260                 265                 270 

Asn Asp Asp Asp Gln Glu Ala Gly Gln Lys Leu Thr Tyr Ala Ile Arg
        275                 280                 285 

Arg Ala Lys Leu Met Arg Ala Leu Leu Glu Ser Gly Phe Gln Val Asp
    290                 295                 300 

Asn Ser Glu Ala Gly Leu Tyr Leu Trp Ala Thr Arg Glu Glu Pro Cys
305                 310                 315                 320 

Arg Asp Thr Val Asp Trp Phe Ala Glu Arg Gly Ile Leu Val Ala Pro
                325                 330                 335 

Gly Asp Phe Tyr Gly Pro Arg Gly Ala Gln His Val Arg Val Ala Met
            340                 345                 350 

Thr Glu Thr Asp Glu Arg Val Asp Ala Phe Val Ser Arg Leu Ser
        355                 360                 365 




<210>    50
<211>    1104
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (P209L)_NCgl1058


<400>    50
atgacctctc gcaccccgct tgtttctgtt cttcctgatt ttccgtggga ttcgctcgct         60

tccgcaaaag ccaaagctgc gtctcacccg gatgggatcg tgaatctttc tgttggcact        120

ccggttgatc cggtcgcgcc cagcattcag atcgcgttgg cagaagcagc ggggttttcg        180

ggttaccctc aaaccatcgg caccccggaa ctccgcgcag ccatcagggg cgcgcttgag        240

cggcgctaca acatgacaaa gcttgtcgac gcctccctcc tccccgtcgt gggtaccaag        300

gaggcaattg cccttcttcc attcgcgttg ggtatttccg gcaccgttgt catcccagag        360

attgcgtacc caacctacga agtcgctgtc gtggccgcag gatgcaccgt gttgcgttct        420

gattcgctgt ttaagctcgg cccgcagatc ccgtcgatga tgtttatcaa ctcaccatcc        480

aaccccacag gcaaggttct gggcatccca cacttgcgca aggttgtgaa gtgggcgcag        540

gaaaacaacg tgatcctcgc agctgatgaa tgctacttgg gtcttggctg ggacgatgaa        600

aacccaccga tctcaatttt ggatctacgt gtctgcgatg gcgaccacac caacttgatc        660

gccattcact cgctgtctaa aacctcaaac ctcgcttctt accgcgcagg ttacctcgtt        720

ggcgatccag cgctgattgg tgaactcacg gaagtccgta agaacttggg tctcatggtt        780

cctttcccaa tccagcaggc catgatcgca gccctcaacg acgatgacca agaggcaggg        840

cagaagctca cctacgcgat tcgtcgagca aaactcatgc gcgccctgtt ggaatccggc        900

tttcaggtag ataattctga agcgggtctg tacctctggg cgacgcgtga agaaccttgc        960

cgtgacactg tcgattggtt cgctgagcgt ggcattctcg ttgccccagg agacttctat       1020

ggccctcgcg gagcgcagca tgtgcgtgtg gcgatgaccg aaaccgacga gcgcgtcgac       1080

gcctttgttt ctcgcctgag ctaa                                              1104


<210>    51
<211>    367
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_N-succinyldiaminopimelate aminotransferase


<400>    51
Met Thr Ser Arg Thr Pro Leu Val Ser Val Leu Pro Asp Phe Pro Trp
  1               5                  10                  15 

Asp Ser Leu Ala Ser Ala Lys Ala Lys Ala Ala Ser His Pro Asp Gly
             20                  25                  30 

Ile Val Asn Leu Ser Val Gly Thr Pro Val Asp Pro Val Ala Pro Ser
         35                  40                  45 

Ile Gln Ile Ala Leu Ala Glu Ala Ala Gly Phe Ser Gly Tyr Pro Gln
     50                  55                  60 

Thr Ile Gly Thr Pro Glu Leu Arg Ala Ala Ile Arg Gly Ala Leu Glu
 65                  70                  75                  80 

Arg Arg Tyr Asn Met Thr Lys Leu Val Asp Ala Ser Leu Leu Pro Val
                 85                  90                  95 

Val Gly Thr Lys Glu Ala Ile Ala Leu Leu Pro Phe Ala Leu Gly Ile
            100                 105                 110 

Ser Gly Thr Val Val Ile Pro Glu Ile Ala Tyr Pro Thr Tyr Glu Val
        115                 120                 125 

Ala Val Val Ala Ala Gly Cys Thr Val Leu Arg Ser Asp Ser Leu Phe
    130                 135                 140 

Lys Leu Gly Pro Gln Ile Pro Ser Met Met Phe Ile Asn Ser Pro Ser
145                 150                 155                 160 

Asn Pro Thr Gly Lys Val Leu Gly Ile Pro His Leu Arg Lys Val Val
                165                 170                 175 

Lys Trp Ala Gln Glu Asn Asn Val Ile Leu Ala Ala Asp Glu Cys Tyr
            180                 185                 190 

Leu Gly Leu Gly Trp Asp Asp Glu Asn Pro Pro Ile Ser Ile Leu Asp
        195                 200                 205 

Pro Arg Val Cys Asp Gly Asp His Thr Asn Leu Ile Ala Ile His Ser
    210                 215                 220 

Leu Ser Lys Thr Ser Asn Leu Ala Ser Tyr Arg Ala Gly Tyr Leu Val
225                 230                 235                 240 

Gly Asp Pro Ala Leu Ile Gly Glu Leu Thr Glu Val Arg Lys Asn Leu
                245                 250                 255 

Gly Leu Met Val Pro Phe Pro Ile Gln Gln Ala Met Ile Ala Ala Leu
            260                 265                 270 

Asn Asp Asp Asp Gln Glu Ala Gly Gln Lys Leu Thr Tyr Ala Ile Arg
        275                 280                 285 

Arg Ala Lys Leu Met Arg Ala Leu Leu Glu Ser Gly Phe Gln Val Asp
    290                 295                 300 

Asn Ser Glu Ala Gly Leu Tyr Leu Trp Ala Thr Arg Glu Glu Pro Cys
305                 310                 315                 320 

Arg Asp Thr Val Asp Trp Phe Ala Glu Arg Gly Ile Leu Val Ala Pro
                325                 330                 335 

Gly Asp Phe Tyr Gly Pro Arg Gly Ala Gln His Val Arg Val Ala Met
            340                 345                 350 

Thr Glu Thr Asp Glu Arg Val Asp Ala Phe Val Ser Arg Leu Ser
        355                 360                 365 




<210>    52
<211>    1104
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl1058


<400>    52
atgacctctc gcaccccgct tgtttctgtt cttcctgatt ttccgtggga ttcgctcgct         60

tccgcaaaag ccaaagctgc gtctcacccg gatgggatcg tgaatctttc tgttggcact        120

ccggttgatc cggtcgcgcc cagcattcag atcgcgttgg cagaagcagc ggggttttcg        180

ggttaccctc aaaccatcgg caccccggaa ctccgcgcag ccatcagggg cgcgcttgag        240

cggcgctaca acatgacaaa gcttgtcgac gcctccctcc tccccgtcgt gggtaccaag        300

gaggcaattg cccttcttcc attcgcgttg ggtatttccg gcaccgttgt catcccagag        360

attgcgtacc caacctacga agtcgctgtc gtggccgcag gatgcaccgt gttgcgttct        420

gattcgctgt ttaagctcgg cccgcagatc ccgtcgatga tgtttatcaa ctcaccatcc        480

aaccccacag gcaaggttct gggcatccca cacttgcgca aggttgtgaa gtgggcgcag        540

gaaaacaacg tgatcctcgc agctgatgaa tgctacttgg gtcttggctg ggacgatgaa        600

aacccaccga tctcaatttt ggatccacgt gtctgcgatg gcgaccacac caacttgatc        660

gccattcact cgctgtctaa aacctcaaac ctcgcttctt accgcgcagg ttacctcgtt        720

ggcgatccag cgctgattgg tgaactcacg gaagtccgta agaacttggg tctcatggtt        780

cctttcccaa tccagcaggc catgatcgca gccctcaacg acgatgacca agaggcaggg        840

cagaagctca cctacgcgat tcgtcgagca aaactcatgc gcgccctgtt ggaatccggc        900

tttcaggtag ataattctga agcgggtctg tacctctggg cgacgcgtga agaaccttgc        960

cgtgacactg tcgattggtt cgctgagcgt ggcattctcg ttgccccagg agacttctat       1020

ggccctcgcg gagcgcagca tgtgcgtgtg gcgatgaccg aaaccgacga gcgcgtcgac       1080

gcctttgttt ctcgcctgag ctaa                                              1104


<210>    53
<211>    892
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (Y592F)_helicase


<400>    53
Met Ala Glu Ser Asn Ala Met Asp Arg Ala Gln Ile Ser Ala Leu Leu
  1               5                  10                  15 

Asp Arg Ala Gln His Thr Ile Asn Leu Ala Glu Gln Ala Asn Asn Val
             20                  25                  30 

Leu Arg Leu Leu Lys Thr Pro Gly Thr Ala Thr Val Gly Asp Asn Gly
         35                  40                  45 

Thr Leu Gly Thr Asp Thr Tyr Leu Ile Pro Ser Arg Asn Ile Thr Trp
     50                  55                  60 

Pro Asp Asn Leu Tyr Val Asn Val Phe Leu Asp Gly Met Asn Ala Glu
 65                  70                  75                  80 

Ala Thr Leu Thr Asp Tyr Val Ala Ser Val Ala Ser Ile Pro Arg Leu
                 85                  90                  95 

Cys Gln Ile Ile Asn Glu Gly Gln Gly Gly Met Phe Arg Arg Leu Phe
            100                 105                 110 

Asn Pro Thr Lys Val Gln Ala Gly Asp Gln Ala Val Phe Asp Leu Met
        115                 120                 125 

Val Lys Leu Asp Glu Ile Ser Ser Thr Thr His Glu Val Ser Arg Met
    130                 135                 140 

Leu Glu Gly Val His Ala Ala Arg Thr Arg Gln Gln Gln Gly Val Ala
145                 150                 155                 160 

Leu Phe Pro Gly Ile His Gly Val Gly Glu Arg Tyr Ile Glu Arg Ala
                165                 170                 175 

Gln Gln Val Leu Ala Ser Ala Leu Gly Ile Ala Gly Phe Gly Ala Glu
            180                 185                 190 

Pro Trp Asp Gly His Thr Leu Ala Gln Ala Arg Arg Val Val Gln Arg
        195                 200                 205 

Tyr Ala Gln Asp Pro Asn Ser Glu Tyr Arg Leu Lys Ser Glu Ala Glu
    210                 215                 220 

Lys His Leu Thr Ser Ile Asn Glu Leu Arg Val Gln Ile Leu Leu Glu
225                 230                 235                 240 

Gln Leu Pro Val Asp Ala Leu Arg Met Ala Thr Asp His Arg Leu Arg
                245                 250                 255 

Phe Gly Ser Leu Asp Ser Ile His Val Ala Thr Val Ala Asp Val Leu
            260                 265                 270 

Lys Thr His Thr Ser Ile Leu Thr Thr Val Gln Gly Ile Gly Ala Gln
        275                 280                 285 

Thr Ala Gly Arg Met Lys Ala Ala Ala Glu Thr Leu Lys Gln Glu Ala
    290                 295                 300 

Leu Arg Arg Gln Asn Thr Ser Ile Gly Asp Glu Pro Thr Gln Pro Ala
305                 310                 315                 320 

Met Arg Leu Ile Asn Val Leu Ala Arg Phe Asp Gln Thr Glu Thr Ile
                325                 330                 335 

Thr Pro Glu Glu Arg Ala Arg Arg Thr Arg Val Ile Asp Tyr Val Glu
            340                 345                 350 

His Ile Pro Pro Ser Leu Asp Pro Tyr Ile Val Ile Asn Pro Ala Thr
        355                 360                 365 

Pro Glu Phe Asn Asn Phe Thr Asp Asp Leu Arg Trp Ile Asp Ala Asn
    370                 375                 380 

Pro Asn Leu Phe His Pro Gln Thr Ile Thr Thr Pro Pro Ala Asp Ile
385                 390                 395                 400 

Trp Asp Asp Tyr Ile Ser Arg Pro Ala His Tyr Gln Gly Leu Leu Ala
                405                 410                 415 

Thr Leu Leu Gly Arg Asp Ile Glu Gly Ala Asp Glu Leu Leu Asp Ala
            420                 425                 430 

Thr Thr Leu Gln Lys Ile Arg Asp Leu Thr Leu Asp Lys Thr His Leu
        435                 440                 445 

Thr Asp Leu His Leu Arg Gly Tyr Gln Ser Phe Gly Ala Arg Phe Ala
    450                 455                 460 

Ile Ile Gln Lys Lys Thr Leu Leu Gly Asp Asp Met Gly Leu Gly Lys
465                 470                 475                 480 

Thr Val Gln Ala Leu Ser Ala Ala Ala His Leu Ala Ala Thr Glu Lys
                485                 490                 495 

Asp Phe Arg Thr Leu Val Val Val Pro Ala Ser Val Ile Val Asn Trp
            500                 505                 510 

Thr Arg Glu Cys Lys Arg Phe Leu Asn Leu Pro Val Phe Ile Ala His
        515                 520                 525 

Gly Asp Asn Lys Gln Asp Ala Ile Asn Ala Trp Ser Asn Thr Asn Gly
    530                 535                 540 

Ile Ala Ile Cys Thr Tyr Asp Gly Val Arg Thr Met Asp Ile Pro Ala
545                 550                 555                 560 

Pro Gly Leu Val Ile Ala Asp Glu Ala His Leu Ile Lys Asn Pro Ser
                565                 570                 575 

Thr Lys Arg Thr Gln Ala Leu Arg Lys Leu Ile Asp Ala Ala Pro Phe
            580                 585                 590 

Thr Leu Leu Met Thr Gly Thr Pro Leu Glu Asn Lys Val Glu Glu Phe
        595                 600                 605 

Val Asn Leu Val Arg Tyr Ile Gln Pro Glu Leu Ile Thr Arg Gly Met
    610                 615                 620 

Ser Lys Met Gln Ala Glu Asn Phe Arg Glu Arg Ile Ala Pro Ala Tyr
625                 630                 635                 640 

Leu Arg Arg Asn Gln Ala Asp Val Leu Asp Glu Leu Pro Glu Arg Thr
                645                 650                 655 

Asp Ser Ile Asp Trp Ile Asp Leu Thr Pro Glu Asp Arg Ser Ala Tyr
            660                 665                 670 

Asp Asp Gln Val Arg Gln Gly Ser Trp Met Gly Met Arg Arg Ser Ala
        675                 680                 685 

Met Leu Ser Pro Thr Pro Arg Leu Thr Ser Ala Lys Met Gln Arg Ile
    690                 695                 700 

Leu Glu Leu Phe Glu Glu Ala Glu Glu His Gly Arg Lys Ala Leu Ile
705                 710                 715                 720 

Phe Thr Tyr Phe Leu Asp Val Leu Asp Glu Leu Glu Lys His Leu Gly
                725                 730                 735 

Glu Arg Val Ile Gly Arg Ile Ser Gly Asp Val Pro Ala Thr Lys Arg
            740                 745                 750 

Gln Leu Leu Val Asp Ala Leu Ser His Ser Lys Pro Gly Ser Ala Leu
        755                 760                 765 

Ile Ala Gln Ile Thr Ala Gly Gly Val Gly Leu Asn Ile Gln Ser Ala
    770                 775                 780 

Ser Leu Cys Ile Ile Cys Glu Pro Gln Val Lys Pro Thr Ile Glu Gln
785                 790                 795                 800 

Gln Ala Val Ala Arg Val His Arg Met Gly Gln Thr Ala Thr Val Gln
                805                 810                 815 

Val His Arg Leu Ile Gly Asp Glu Thr Ala Asp Glu Arg Met Leu Glu
            820                 825                 830 

Ile Leu Ala Gly Lys Thr His Val Phe Asp Val Tyr Ala Arg Leu Ser
        835                 840                 845 

Glu Thr Ala Glu Ile Pro Asp Ala Val Asp Ile Thr Glu Ser Gln Leu
    850                 855                 860 

Ala Ala Arg Val Ile Asp Glu Glu Arg Ala Arg Leu Gly Leu Thr Glu
865                 870                 875                 880 

Ser Thr Gly Pro Lys Asp Glu Glu Thr Ala Leu Ser
                885                 890        


<210>    54
<211>    2679
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (Y592F)_NCgl1575


<400>    54
atggcagaat caaacgctat ggaccgggca caaatctctg cactgctaga tagagcacag         60

cacacaatca accttgccga acaagcaaac aacgtgctcc gactgttgaa aacacccgga        120

acggccacag taggggacaa cgggacactc ggcaccgata cctatctgat cccatcccgc        180

aacatcacct ggcctgacaa cctgtatgtc aacgtctttc tagacggcat gaatgcagaa        240

gccaccctta ccgattacgt cgcatcagtc gcttcgatcc cacgcctatg ccagatcatc        300

aacgagggcc aaggcggcat gttccgcaga ctattcaacc ccaccaaggt ccaagccggc        360

gaccaagctg tcttcgacct catggtcaaa ctcgacgaga tttcatctac cacccacgaa        420

gtctcccgca tgctcgaggg cgtccacgct gcccgcaccc gccaacaaca aggcgttgca        480

cttttcccag gtattcatgg agtgggagag cgctacatcg aacgcgcaca acaggtactc        540

gcctcagccc tcggtatcgc tggattcggt gccgaaccct gggacggaca tacccttgcc        600

caagcgcgcc gggtagtcca acgctacgcc caagatccta actccgaata ccggctgaaa        660

agcgaagccg agaaacacct cacatccatc aacgagctcc gcgtacagat actcctcgaa        720

caactccccg ttgatgccct acgcatggct accgaccacc gcctgcgctt tggatccctc        780

gattccatcc acgtcgcaac cgtcgccgac gtcctaaaaa cacacacctc catcctcacc        840

accgtgcaag gtatcggcgc ccaaaccgcg gggcggatga aagccgcagc agaaacactc        900

aaacaagaag cactacgccg ccaaaacacc tccatcggcg acgaacctac ccaacccgcc        960

atgcgtctaa tcaacgtgct ggcccgcttc gaccaaaccg aaaccatcac gcccgaagaa       1020

cgcgcccgcc gcacccgcgt catcgactac gtagaacaca tacccccaag cctcgacccc       1080

tacatcgtca tcaacccagc aacgcctgag ttcaacaact tcaccgacga cctccgctgg       1140

atcgacgcaa accccaacct cttccaccca caaacaatca ccaccccacc cgccgacatc       1200

tgggacgact acatctcccg tcccgctcac taccaaggcc tgctagccac gctgctcggc       1260

cgcgacatcg aaggcgcaga cgaactcctc gacgccacca ccctccaaaa aatcagagac       1320

ctcaccctcg acaaaactca tctcaccgac ctccacctcc gcggatacca atcattcggc       1380

gcccgcttcg ccatcatcca aaagaaaacc ctcctcggcg acgacatggg actcggcaaa       1440

acagtccaag ccctctccgc agctgcacac cttgccgcca ccgaaaaaga cttccgcacc       1500

ctcgtcgtcg tacccgcatc cgtcattgtt aactggaccc gcgaatgcaa acgcttcctc       1560

aacctccccg tattcatcgc ccacggagac aacaaacaag acgccatcaa cgcctggtct       1620

aacaccaacg gaatcgcaat ctgcacctac gacggcgtcc gcaccatgga catccccgcg       1680

ccgggtctgg tcattgccga tgaagcccac ctgatcaaaa acccctccac caaacgcacc       1740

caagcactgc gcaaacttat cgacgccgcc ccattcaccc ttctgatgac cggcacacca       1800

ctagaaaaca aagtggaaga gtttgtaaat ctcgtgcgct acatccaacc ggagctgatc       1860

acccgtggca tgtccaaaat gcaggccgag aatttccgcg agcgcatcgc accagcctat       1920

ctgcgcagaa atcaagctga tgtgcttgac gaactcccag agcgcaccga ctccatcgac       1980

tggatcgacc tcaccccaga agaccgcagc gcctacgacg accaagtccg ccaaggcagc       2040

tggatgggca tgcgccgctc cgccatgctc tcaccaacac cacgcctaac ttccgcaaaa       2100

atgcaacgca tcctagaact cttcgaagaa gcagaagaac acggccgcaa agccctcatc       2160

ttcacctact tcctcgacgt cctcgacgaa ctggaaaagc atctaggcga gcgcgtcatc       2220

ggccgcattt ccggcgacgt gccagccacc aagcgccaat tgcttgtcga cgccctgtcc       2280

cactccaaac ccggatccgc cctcattgcc caaatcaccg ccgggggagt aggcctaaac       2340

atccaatccg cgagcctatg cattatttgt gaacctcaag taaagccaac catcgaacag       2400

caggccgtcg cccgagtcca ccgcatgggc caaaccgcca ccgtccaagt ccaccgactc       2460

atcggcgacg aaaccgcaga cgaacgcatg ctagaaatcc tggcaggcaa aactcacgtc       2520

ttcgacgtct acgcccggct atctgaaacc gcagagattc cagatgctgt ggatatcact       2580

gaatcacagc tggcagcacg ggttattgat gaggagcgtg cacggttagg gcttactgaa       2640

tccactggcc ctaaagatga agaaacggcc ttaagctag                              2679


<210>    55
<211>    892
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_helicase


<400>    55
Met Ala Glu Ser Asn Ala Met Asp Arg Ala Gln Ile Ser Ala Leu Leu
  1               5                  10                  15 

Asp Arg Ala Gln His Thr Ile Asn Leu Ala Glu Gln Ala Asn Asn Val
             20                  25                  30 

Leu Arg Leu Leu Lys Thr Pro Gly Thr Ala Thr Val Gly Asp Asn Gly
         35                  40                  45 

Thr Leu Gly Thr Asp Thr Tyr Leu Ile Pro Ser Arg Asn Ile Thr Trp
     50                  55                  60 

Pro Asp Asn Leu Tyr Val Asn Val Phe Leu Asp Gly Met Asn Ala Glu
 65                  70                  75                  80 

Ala Thr Leu Thr Asp Tyr Val Ala Ser Val Ala Ser Ile Pro Arg Leu
                 85                  90                  95 

Cys Gln Ile Ile Asn Glu Gly Gln Gly Gly Met Phe Arg Arg Leu Phe
            100                 105                 110 

Asn Pro Thr Lys Val Gln Ala Gly Asp Gln Ala Val Phe Asp Leu Met
        115                 120                 125 

Val Lys Leu Asp Glu Ile Ser Ser Thr Thr His Glu Val Ser Arg Met
    130                 135                 140 

Leu Glu Gly Val His Ala Ala Arg Thr Arg Gln Gln Gln Gly Val Ala
145                 150                 155                 160 

Leu Phe Pro Gly Ile His Gly Val Gly Glu Arg Tyr Ile Glu Arg Ala
                165                 170                 175 

Gln Gln Val Leu Ala Ser Ala Leu Gly Ile Ala Gly Phe Gly Ala Glu
            180                 185                 190 

Pro Trp Asp Gly His Thr Leu Ala Gln Ala Arg Arg Val Val Gln Arg
        195                 200                 205 

Tyr Ala Gln Asp Pro Asn Ser Glu Tyr Arg Leu Lys Ser Glu Ala Glu
    210                 215                 220 

Lys His Leu Thr Ser Ile Asn Glu Leu Arg Val Gln Ile Leu Leu Glu
225                 230                 235                 240 

Gln Leu Pro Val Asp Ala Leu Arg Met Ala Thr Asp His Arg Leu Arg
                245                 250                 255 

Phe Gly Ser Leu Asp Ser Ile His Val Ala Thr Val Ala Asp Val Leu
            260                 265                 270 

Lys Thr His Thr Ser Ile Leu Thr Thr Val Gln Gly Ile Gly Ala Gln
        275                 280                 285 

Thr Ala Gly Arg Met Lys Ala Ala Ala Glu Thr Leu Lys Gln Glu Ala
    290                 295                 300 

Leu Arg Arg Gln Asn Thr Ser Ile Gly Asp Glu Pro Thr Gln Pro Ala
305                 310                 315                 320 

Met Arg Leu Ile Asn Val Leu Ala Arg Phe Asp Gln Thr Glu Thr Ile
                325                 330                 335 

Thr Pro Glu Glu Arg Ala Arg Arg Thr Arg Val Ile Asp Tyr Val Glu
            340                 345                 350 

His Ile Pro Pro Ser Leu Asp Pro Tyr Ile Val Ile Asn Pro Ala Thr
        355                 360                 365 

Pro Glu Phe Asn Asn Phe Thr Asp Asp Leu Arg Trp Ile Asp Ala Asn
    370                 375                 380 

Pro Asn Leu Phe His Pro Gln Thr Ile Thr Thr Pro Pro Ala Asp Ile
385                 390                 395                 400 

Trp Asp Asp Tyr Ile Ser Arg Pro Ala His Tyr Gln Gly Leu Leu Ala
                405                 410                 415 

Thr Leu Leu Gly Arg Asp Ile Glu Gly Ala Asp Glu Leu Leu Asp Ala
            420                 425                 430 

Thr Thr Leu Gln Lys Ile Arg Asp Leu Thr Leu Asp Lys Thr His Leu
        435                 440                 445 

Thr Asp Leu His Leu Arg Gly Tyr Gln Ser Phe Gly Ala Arg Phe Ala
    450                 455                 460 

Ile Ile Gln Lys Lys Thr Leu Leu Gly Asp Asp Met Gly Leu Gly Lys
465                 470                 475                 480 

Thr Val Gln Ala Leu Ser Ala Ala Ala His Leu Ala Ala Thr Glu Lys
                485                 490                 495 

Asp Phe Arg Thr Leu Val Val Val Pro Ala Ser Val Ile Val Asn Trp
            500                 505                 510 

Thr Arg Glu Cys Lys Arg Phe Leu Asn Leu Pro Val Phe Ile Ala His
        515                 520                 525 

Gly Asp Asn Lys Gln Asp Ala Ile Asn Ala Trp Ser Asn Thr Asn Gly
    530                 535                 540 

Ile Ala Ile Cys Thr Tyr Asp Gly Val Arg Thr Met Asp Ile Pro Ala
545                 550                 555                 560 

Pro Gly Leu Val Ile Ala Asp Glu Ala His Leu Ile Lys Asn Pro Ser
                565                 570                 575 

Thr Lys Arg Thr Gln Ala Leu Arg Lys Leu Ile Asp Ala Ala Pro Tyr
            580                 585                 590 

Thr Leu Leu Met Thr Gly Thr Pro Leu Glu Asn Lys Val Glu Glu Phe
        595                 600                 605 

Val Asn Leu Val Arg Tyr Ile Gln Pro Glu Leu Ile Thr Arg Gly Met
    610                 615                 620 

Ser Lys Met Gln Ala Glu Asn Phe Arg Glu Arg Ile Ala Pro Ala Tyr
625                 630                 635                 640 

Leu Arg Arg Asn Gln Ala Asp Val Leu Asp Glu Leu Pro Glu Arg Thr
                645                 650                 655 

Asp Ser Ile Asp Trp Ile Asp Leu Thr Pro Glu Asp Arg Ser Ala Tyr
            660                 665                 670 

Asp Asp Gln Val Arg Gln Gly Ser Trp Met Gly Met Arg Arg Ser Ala
        675                 680                 685 

Met Leu Ser Pro Thr Pro Arg Leu Thr Ser Ala Lys Met Gln Arg Ile
    690                 695                 700 

Leu Glu Leu Phe Glu Glu Ala Glu Glu His Gly Arg Lys Ala Leu Ile
705                 710                 715                 720 

Phe Thr Tyr Phe Leu Asp Val Leu Asp Glu Leu Glu Lys His Leu Gly
                725                 730                 735 

Glu Arg Val Ile Gly Arg Ile Ser Gly Asp Val Pro Ala Thr Lys Arg
            740                 745                 750 

Gln Leu Leu Val Asp Ala Leu Ser His Ser Lys Pro Gly Ser Ala Leu
        755                 760                 765 

Ile Ala Gln Ile Thr Ala Gly Gly Val Gly Leu Asn Ile Gln Ser Ala
    770                 775                 780 

Ser Leu Cys Ile Ile Cys Glu Pro Gln Val Lys Pro Thr Ile Glu Gln
785                 790                 795                 800 

Gln Ala Val Ala Arg Val His Arg Met Gly Gln Thr Ala Thr Val Gln
                805                 810                 815 

Val His Arg Leu Ile Gly Asp Glu Thr Ala Asp Glu Arg Met Leu Glu
            820                 825                 830 

Ile Leu Ala Gly Lys Thr His Val Phe Asp Val Tyr Ala Arg Leu Ser
        835                 840                 845 

Glu Thr Ala Glu Ile Pro Asp Ala Val Asp Ile Thr Glu Ser Gln Leu
    850                 855                 860 

Ala Ala Arg Val Ile Asp Glu Glu Arg Ala Arg Leu Gly Leu Thr Glu
865                 870                 875                 880 

Ser Thr Gly Pro Lys Asp Glu Glu Thr Ala Leu Ser
                885                 890        


<210>    56
<211>    2679
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl1575


<400>    56
atggcagaat caaacgctat ggaccgggca caaatctctg cactgctaga tagagcacag         60

cacacaatca accttgccga acaagcaaac aacgtgctcc gactgttgaa aacacccgga        120

acggccacag taggggacaa cgggacactc ggcaccgata cctatctgat cccatcccgc        180

aacatcacct ggcctgacaa cctgtatgtc aacgtctttc tagacggcat gaatgcagaa        240

gccaccctta ccgattacgt cgcatcagtc gcttcgatcc cacgcctatg ccagatcatc        300

aacgagggcc aaggcggcat gttccgcaga ctattcaacc ccaccaaggt ccaagccggc        360

gaccaagctg tcttcgacct catggtcaaa ctcgacgaga tttcatctac cacccacgaa        420

gtctcccgca tgctcgaggg cgtccacgct gcccgcaccc gccaacaaca aggcgttgca        480

cttttcccag gtattcatgg agtgggagag cgctacatcg aacgcgcaca acaggtactc        540

gcctcagccc tcggtatcgc tggattcggt gccgaaccct gggacggaca tacccttgcc        600

caagcgcgcc gggtagtcca acgctacgcc caagatccta actccgaata ccggctgaaa        660

agcgaagccg agaaacacct cacatccatc aacgagctcc gcgtacagat actcctcgaa        720

caactccccg ttgatgccct acgcatggct accgaccacc gcctgcgctt tggatccctc        780

gattccatcc acgtcgcaac cgtcgccgac gtcctaaaaa cacacacctc catcctcacc        840

accgtgcaag gtatcggcgc ccaaaccgcg gggcggatga aagccgcagc agaaacactc        900

aaacaagaag cactacgccg ccaaaacacc tccatcggcg acgaacctac ccaacccgcc        960

atgcgtctaa tcaacgtgct ggcccgcttc gaccaaaccg aaaccatcac gcccgaagaa       1020

cgcgcccgcc gcacccgcgt catcgactac gtagaacaca tacccccaag cctcgacccc       1080

tacatcgtca tcaacccagc aacgcctgag ttcaacaact tcaccgacga cctccgctgg       1140

atcgacgcaa accccaacct cttccaccca caaacaatca ccaccccacc cgccgacatc       1200

tgggacgact acatctcccg tcccgctcac taccaaggcc tgctagccac gctgctcggc       1260

cgcgacatcg aaggcgcaga cgaactcctc gacgccacca ccctccaaaa aatcagagac       1320

ctcaccctcg acaaaactca tctcaccgac ctccacctcc gcggatacca atcattcggc       1380

gcccgcttcg ccatcatcca aaagaaaacc ctcctcggcg acgacatggg actcggcaaa       1440

acagtccaag ccctctccgc agctgcacac cttgccgcca ccgaaaaaga cttccgcacc       1500

ctcgtcgtcg tacccgcatc cgtcattgtt aactggaccc gcgaatgcaa acgcttcctc       1560

aacctccccg tattcatcgc ccacggagac aacaaacaag acgccatcaa cgcctggtct       1620

aacaccaacg gaatcgcaat ctgcacctac gacggcgtcc gcaccatgga catccccgcg       1680

ccgggtctgg tcattgccga tgaagcccac ctgatcaaaa acccctccac caaacgcacc       1740

caagcactgc gcaaacttat cgacgccgcc ccatacaccc ttctgatgac cggcacacca       1800

ctagaaaaca aagtggaaga gtttgtaaat ctcgtgcgct acatccaacc ggagctgatc       1860

acccgtggca tgtccaaaat gcaggccgag aatttccgcg agcgcatcgc accagcctat       1920

ctgcgcagaa atcaagctga tgtgcttgac gaactcccag agcgcaccga ctccatcgac       1980

tggatcgacc tcaccccaga agaccgcagc gcctacgacg accaagtccg ccaaggcagc       2040

tggatgggca tgcgccgctc cgccatgctc tcaccaacac cacgcctaac ttccgcaaaa       2100

atgcaacgca tcctagaact cttcgaagaa gcagaagaac acggccgcaa agccctcatc       2160

ttcacctact tcctcgacgt cctcgacgaa ctggaaaagc atctaggcga gcgcgtcatc       2220

ggccgcattt ccggcgacgt gccagccacc aagcgccaat tgcttgtcga cgccctgtcc       2280

cactccaaac ccggatccgc cctcattgcc caaatcaccg ccgggggagt aggcctaaac       2340

atccaatccg cgagcctatg cattatttgt gaacctcaag taaagccaac catcgaacag       2400

caggccgtcg cccgagtcca ccgcatgggc caaaccgcca ccgtccaagt ccaccgactc       2460

atcggcgacg aaaccgcaga cgaacgcatg ctagaaatcc tggcaggcaa aactcacgtc       2520

ttcgacgtct acgcccggct atctgaaacc gcagagattc cagatgctgt ggatatcact       2580

gaatcacagc tggcagcacg ggttattgat gaggagcgtg cacggttagg gcttactgaa       2640

tccactggcc ctaaagatga agaaacggcc ttaagctag                              2679


<210>    57
<211>    217
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (E170K)_NCgl1089_amino acid


<400>    57
Met Ser Ile Trp Lys Arg Leu Leu Val Gln Tyr Pro Arg Phe Ala Asp
  1               5                  10                  15 

Thr Leu Thr Ala Gly Gln Pro Ile Thr Leu Glu Glu Leu Ala Thr Pro
             20                  25                  30 

Glu Val Ile Leu Glu Ala Val Ala Lys Gly Gln Glu Ile Phe Gly Ile
         35                  40                  45 

Glu Gln Pro Lys His Ala Ala Gln Leu Trp Phe His Ser Leu Cys Thr
     50                  55                  60 

Ala Ile Val Gly Pro Ala Val Thr Ala Met Val Glu Phe Asp Val Ile
 65                  70                  75                  80 

Pro Ser Leu Asp Ile Arg Arg Gly Gln Leu His Asn Ile Asp Gly Tyr
                 85                  90                  95 

Trp Phe Gly Phe Arg Pro Glu Glu Met Leu Val Asp Ala Ser Leu His
            100                 105                 110 

Leu Ser Gly Thr Gln Phe Gly Glu Ser Ile Arg Val Val Ile Asp Ala
        115                 120                 125 

Leu Cys Ala Ala Thr Asp Leu Arg Pro Ala Pro Leu Trp Ala Val Ala
    130                 135                 140 

Ser Asp Ala Leu Gly Ile Ala Ala Ser Gly Ala Gly Val Glu Ala Phe
145                 150                 155                 160 

Glu Glu Glu His Ala Arg Glu Val Ala Lys Ala Leu Ile Glu Gly Met
                165                 170                 175 

Asn Ser Val Asn Ser Val Pro Ser Pro Arg Phe Asn Asp Asp Asp Tyr
            180                 185                 190 

Phe Ile Arg Ala Gly Cys Cys Met Ile Phe His Ser Pro Arg Ala Asp
        195                 200                 205 

Phe Cys Thr Ser Cys Pro Gln Lys Arg
    210                 215        


<210>    58
<211>    654
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (E170K)_NCgl1089_nucleic acid


<400>    58
atgagcatct ggaaacgtct gttagtgcag tacccgcgct tcgccgacac cctcacagcc         60

ggccaaccca tcacgctcga ggaattagca accccggaag tgatcttgga agctgttgcc        120

aaaggccaag aaattttcgg cattgagcag ccaaaacatg cagcacaact ctggtttcac        180

tccctgtgca ccgcaattgt cggccccgcc gtcaccgcca tggtggaatt cgatgtcatc        240

cccagcctcg acatacgtcg aggtcagctg cataacatcg acggttactg gttcggcttc        300

aggccggagg agatgcttgt cgacgcctcc ctccacctgt cgggcaccca attcggcgag        360

agtatccgcg tggtgattga tgcattatgc gctgccacgg atctgcgacc ggcacccctg        420

tgggcggttg cctcagatgc gttgggaatc gcagctagcg gcgcaggtgt cgaggccttt        480

gaagaagaac atgcccgcga ggtggcgaaa gccctcattg aaggaatgaa tagtgtgaac        540

tcagttccat cgccgcggtt taacgacgac gattatttca ttcgagctgg atgctgcatg        600

attttccact caccacgagc tgatttttgc acgtcgtgcc cacagaagag gtga              654


<210>    59
<211>    217
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl1089_amino acid


<400>    59
Met Ser Ile Trp Lys Arg Leu Leu Val Gln Tyr Pro Arg Phe Ala Asp
  1               5                  10                  15 

Thr Leu Thr Ala Gly Gln Pro Ile Thr Leu Glu Glu Leu Ala Thr Pro
             20                  25                  30 

Glu Val Ile Leu Glu Ala Val Ala Lys Gly Gln Glu Ile Phe Gly Ile
         35                  40                  45 

Glu Gln Pro Lys His Ala Ala Gln Leu Trp Phe His Ser Leu Cys Thr
     50                  55                  60 

Ala Ile Val Gly Pro Ala Val Thr Ala Met Val Glu Phe Asp Val Ile
 65                  70                  75                  80 

Pro Ser Leu Asp Ile Arg Arg Gly Gln Leu His Asn Ile Asp Gly Tyr
                 85                  90                  95 

Trp Phe Gly Phe Arg Pro Glu Glu Met Leu Val Asp Ala Ser Leu His
            100                 105                 110 

Leu Ser Gly Thr Gln Phe Gly Glu Ser Ile Arg Val Val Ile Asp Ala
        115                 120                 125 

Leu Cys Ala Ala Thr Asp Leu Arg Pro Ala Pro Leu Trp Ala Val Ala
    130                 135                 140 

Ser Asp Ala Leu Gly Ile Ala Ala Ser Gly Ala Gly Val Glu Ala Phe
145                 150                 155                 160 

Glu Glu Glu His Ala Arg Glu Val Ala Glu Ala Leu Ile Glu Gly Met
                165                 170                 175 

Asn Ser Val Asn Ser Val Pro Ser Pro Arg Phe Asn Asp Asp Asp Tyr
            180                 185                 190 

Phe Ile Arg Ala Gly Cys Cys Met Ile Phe His Ser Pro Arg Ala Asp
        195                 200                 205 

Phe Cys Thr Ser Cys Pro Gln Lys Arg
    210                 215        


<210>    60
<211>    654
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl1089_nucleic acid


<400>    60
atgagcatct ggaaacgtct gttagtgcag tacccgcgct tcgccgacac cctcacagcc         60

ggccaaccca tcacgctcga ggaattagca accccggaag tgatcttgga agctgttgcc        120

aaaggccaag aaattttcgg cattgagcag ccaaaacatg cagcacaact ctggtttcac        180

tccctgtgca ccgcaattgt cggccccgcc gtcaccgcca tggtggaatt cgatgtcatc        240

cccagcctcg acatacgtcg aggtcagctg cataacatcg acggttactg gttcggcttc        300

aggccggagg agatgcttgt cgacgcctcc ctccacctgt cgggcaccca attcggcgag        360

agtatccgcg tggtgattga tgcattatgc gctgccacgg atctgcgacc ggcacccctg        420

tgggcggttg cctcagatgc gttgggaatc gcagctagcg gcgcaggtgt cgaggccttt        480

gaagaagaac atgcccgcga ggtggcggaa gccctcattg aaggaatgaa tagtgtgaac        540

tcagttccat cgccgcggtt taacgacgac gattatttca ttcgagctgg atgctgcatg        600

attttccact caccacgagc tgatttttgc acgtcgtgcc cacagaagag gtga              654



<210>    61
<211>    337
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (A321V)_sugar phosphate isomerase/epimerase


<400>    61
Met Lys Leu Gly Leu Tyr Asn Ala Ile Phe His Asp Arg Thr Leu Pro
  1               5                  10                  15 

Glu Ala Leu Ala Ala Ile Lys Ala Ala Gly Leu Thr Gly Ile Glu Leu
             20                  25                  30 

Asn Thr Gly Gly Phe Leu Pro Ala Thr His Ile Pro Thr Ile Asp Asp
         35                  40                  45 

Ile Leu Val Ser Asp Asp Ala Arg Asp Glu Phe Leu Gly Ile Phe Glu
     50                  55                  60 

Gly Thr Gly Val Asp Ile Tyr Gly Leu Asn Cys Asn Gly Asn Pro Leu
 65                  70                  75                  80 

His Pro Asn Lys Ala Ile Gly Asp Lys His Ala Glu Asp Ile Arg Arg
                 85                  90                  95 

Ser Ile Arg Leu Ala Glu Arg Leu Gly Gln Asn Arg Val Val Thr Met
            100                 105                 110 

Ser Gly Leu Pro Gly Gly Glu Pro Gly Ala Lys Tyr Thr Asn Trp Val
        115                 120                 125 

Val Asn Ala Trp Asn Ser Ala Ala Leu Asp Val Leu Asp Tyr Gln Trp
    130                 135                 140 

Asp Ile Ala Ala Glu Phe Trp Arg Glu Thr Asp Arg Phe Ala Ala Asp
145                 150                 155                 160 

His Gly Val Lys Val Ala Leu Glu Leu His Pro Gln Asn Ile Val Phe
                165                 170                 175 

Asn Ser Ala Asp Val His Lys Leu Ile Asp Leu Thr Gly Ala Thr His
            180                 185                 190 

Val Gly Val Glu Leu Asp Ala Ser His Leu Phe Trp Gln Gln Met Asp
        195                 200                 205 

Pro Ile Ala Val Ile Asp His Leu Gly Glu Leu Ile Phe His Ala Ala
    210                 215                 220 

Ala Lys Asp Val Arg Val Asn Lys Glu Trp Ala Gln Leu Asn Gly Val
225                 230                 235                 240 

Leu Asp Asn Ser Phe Arg Arg Leu Asp Pro Ser Glu Asn Arg Thr Asn
                245                 250                 255 

Leu Gly Gly Asp Glu Trp Ala Asn Glu Trp Pro Lys Asn Ser Ala Trp
            260                 265                 270 

Asp Phe Val Ala Leu Gly Arg Gly His Asp Val Ala Tyr Trp Thr Glu
        275                 280                 285 

Phe Leu Arg Ala Leu His Arg Val Asp Pro Asn Met Leu Val Asn Ile
    290                 295                 300 

Glu His Glu Asp Val Ser Leu Gly Arg Glu Glu Gly Val Asn Glu Ala
305                 310                 315                 320 

Val Lys Val Leu Ile Glu Ala Asn Lys Ala Leu Glu Glu Ser Leu Val
                325                 330                 335 

Ser
   


<210>    62
<211>    1014
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (A321V)_NCgl0169


<400>    62
atgaaactcg gtctctacaa cgcgatcttc cacgaccgca ccctgccaga agcgctcgca         60

gccatcaaag ctgcaggtct caccggaatt gaactcaaca ccggcggatt tttgcctgca        120

acccacatcc cgaccatcga tgacatcctg gtcagcgatg atgcccgcga tgaattcctc        180

gggattttcg aaggcaccgg cgtcgacatc tacggcctta actgcaacgg caacccgctt        240

caccccaaca aggcgatcgg ggacaagcat gccgaagaca ttcgacgttc catccgcctc        300

gcagagcgcc tcggccaaaa ccgtgtggtc accatgtctg gtcttcctgg tggcgaacca        360

ggcgcgaagt acaccaactg ggttgtcaac gcgtggaact ccgcagcctt ggatgtcctt        420

gattaccaat gggatatcgc agctgaattc tggcgcgaga ccgaccgctt cgccgcagat        480

cacggcgtga aagtggctct tgagctgcac ccacagaaca tcgtgttcaa ctccgctgac        540

gtgcataagc tcatcgatct caccggcgcc acccacgtgg gcgtcgaact ggatgcatca        600

cacctgttct ggcagcagat ggacccaatc gctgtgattg atcacctcgg cgagctcatc        660

ttccacgccg ccgccaaaga cgtgcgagtt aataaggaat gggctcagct caacggtgtg        720

ctggacaaca gcttccgacg ccttgaccca tccgaaaacc gcaccaactt gggcggcgac        780

gagtgggcga atgaatggcc aaagaactct gcttgggatt tcgttgctct gggccgcggt        840

catgacgttg cttactggac cgaattcctc cgcgcacttc accgcgtcga tccaaacatg        900

ctggtcaaca tcgaacacga ggatgtttca ctcggtcgcg aagaaggcgt caacgaagcc        960

gttaaggtgc tgatcgaggc caacaaggca ctcgaagagt ccctggtttc ttaa             1014


<210>    63
<211>    337
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_sugar phosphate isomerase/epimerase


<400>    63
Met Lys Leu Gly Leu Tyr Asn Ala Ile Phe His Asp Arg Thr Leu Pro
  1               5                  10                  15 

Glu Ala Leu Ala Ala Ile Lys Ala Ala Gly Leu Thr Gly Ile Glu Leu
             20                  25                  30 

Asn Thr Gly Gly Phe Leu Pro Ala Thr His Ile Pro Thr Ile Asp Asp
         35                  40                  45 

Ile Leu Val Ser Asp Asp Ala Arg Asp Glu Phe Leu Gly Ile Phe Glu
     50                  55                  60 

Gly Thr Gly Val Asp Ile Tyr Gly Leu Asn Cys Asn Gly Asn Pro Leu
 65                  70                  75                  80 

His Pro Asn Lys Ala Ile Gly Asp Lys His Ala Glu Asp Ile Arg Arg
                 85                  90                  95 

Ser Ile Arg Leu Ala Glu Arg Leu Gly Gln Asn Arg Val Val Thr Met
            100                 105                 110 

Ser Gly Leu Pro Gly Gly Glu Pro Gly Ala Lys Tyr Thr Asn Trp Val
        115                 120                 125 

Val Asn Ala Trp Asn Ser Ala Ala Leu Asp Val Leu Asp Tyr Gln Trp
    130                 135                 140 

Asp Ile Ala Ala Glu Phe Trp Arg Glu Thr Asp Arg Phe Ala Ala Asp
145                 150                 155                 160 

His Gly Val Lys Val Ala Leu Glu Leu His Pro Gln Asn Ile Val Phe
                165                 170                 175 

Asn Ser Ala Asp Val His Lys Leu Ile Asp Leu Thr Gly Ala Thr His
            180                 185                 190 

Val Gly Val Glu Leu Asp Ala Ser His Leu Phe Trp Gln Gln Met Asp
        195                 200                 205 

Pro Ile Ala Val Ile Asp His Leu Gly Glu Leu Ile Phe His Ala Ala
    210                 215                 220 

Ala Lys Asp Val Arg Val Asn Lys Glu Trp Ala Gln Leu Asn Gly Val
225                 230                 235                 240 

Leu Asp Asn Ser Phe Arg Arg Leu Asp Pro Ser Glu Asn Arg Thr Asn
                245                 250                 255 

Leu Gly Gly Asp Glu Trp Ala Asn Glu Trp Pro Lys Asn Ser Ala Trp
            260                 265                 270 

Asp Phe Val Ala Leu Gly Arg Gly His Asp Val Ala Tyr Trp Thr Glu
        275                 280                 285 

Phe Leu Arg Ala Leu His Arg Val Asp Pro Asn Met Leu Val Asn Ile
    290                 295                 300 

Glu His Glu Asp Val Ser Leu Gly Arg Glu Glu Gly Val Asn Glu Ala
305                 310                 315                 320 

Ala Lys Val Leu Ile Glu Ala Asn Lys Ala Leu Glu Glu Ser Leu Val
                325                 330                 335 

Ser
   


<210>    64
<211>    1014
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl0169


<400>    64
atgaaactcg gtctctacaa cgcgatcttc cacgaccgca ccctgccaga agcgctcgca         60

gccatcaaag ctgcaggtct caccggaatt gaactcaaca ccggcggatt tttgcctgca        120

acccacatcc cgaccatcga tgacatcctg gtcagcgatg atgcccgcga tgaattcctc        180

gggattttcg aaggcaccgg cgtcgacatc tacggcctta actgcaacgg caacccgctt        240

caccccaaca aggcgatcgg ggacaagcat gccgaagaca ttcgacgttc catccgcctc        300

gcagagcgcc tcggccaaaa ccgtgtggtc accatgtctg gtcttcctgg tggcgaacca        360

ggcgcgaagt acaccaactg ggttgtcaac gcgtggaact ccgcagcctt ggatgtcctt        420

gattaccaat gggatatcgc agctgaattc tggcgcgaga ccgaccgctt cgccgcagat        480

cacggcgtga aagtggctct tgagctgcac ccacagaaca tcgtgttcaa ctccgctgac        540

gtgcataagc tcatcgatct caccggcgcc acccacgtgg gcgtcgaact ggatgcatca        600

cacctgttct ggcagcagat ggacccaatc gctgtgattg atcacctcgg cgagctcatc        660

ttccacgccg ccgccaaaga cgtgcgagtt aataaggaat gggctcagct caacggtgtg        720

ctggacaaca gcttccgacg ccttgaccca tccgaaaacc gcaccaactt gggcggcgac        780

gagtgggcga atgaatggcc aaagaactct gcttgggatt tcgttgctct gggccgcggt        840

catgacgttg cttactggac cgaattcctc cgcgcacttc accgcgtcga tccaaacatg        900

ctggtcaaca tcgaacacga ggatgtttca ctcggtcgcg aagaaggcgt caacgaagcc        960

gctaaggtgc tgatcgaggc caacaaggca ctcgaagagt ccctggtttc ttaa             1014



<210>    65
<211>    441
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (I307V)_cell division membrane protein


<400>    65
Met Asn Thr Leu Glu Arg Leu Lys Leu Arg Arg Thr Glu Met Trp Leu
  1               5                  10                  15 

Leu Ile Leu Ala Thr Leu Val Val Ser Ile Met Phe Ile Ser Leu Glu
             20                  25                  30 

Leu Ala Met Gly Asn Glu Leu Gly Thr His Ile Leu Met Leu Met Gly
         35                  40                  45 

Gly Tyr Ile Gly Ile Phe Ile Val Ala His Leu Ala Met Ala Trp Val
     50                  55                  60 

Ala Pro Phe Ala Asp Gln Ile Met Leu Pro Val Val Ala Val Leu Asn
 65                  70                  75                  80 

Gly Ile Gly Leu Val Met Ile Tyr Arg Leu Asp Glu Ala Thr Gly Tyr
                 85                  90                  95 

Ser Thr Val Asn Ser Gln Leu Met Trp Thr Val Val Gly Val Thr Leu
            100                 105                 110 

Met Val Ala Val Leu Leu Leu Leu Arg Asp Tyr Lys Ser Leu Ser Arg
        115                 120                 125 

Tyr Ser Tyr Leu Leu Gly Val Val Gly Ile Val Leu Leu Ala Leu Pro
    130                 135                 140 

Leu Val Trp Pro Gln Pro Gly Gly Val Glu Ala Arg Ile Trp Ile Trp
145                 150                 155                 160 

Leu Gly Pro Phe Ser Ile Gln Pro Gly Glu Phe Ser Lys Ile Leu Leu
                165                 170                 175 

Leu Leu Phe Phe Ala Gln Leu Leu Ala Thr Lys Arg Ala Leu Phe Thr
            180                 185                 190 

Val Ala Gly Tyr Arg Phe Leu Gly Met Asp Phe Pro Arg Leu Arg Asp
        195                 200                 205 

Leu Ala Pro Ile Leu Val Val Trp Ala Leu Ala Ile Leu Ile Met Ala
    210                 215                 220 

Gly Ala Asn Asp Phe Gly Pro Ala Leu Leu Leu Phe Thr Thr Val Leu
225                 230                 235                 240 

Ala Met Val Tyr Leu Ala Thr Gly Arg Gly Ser Trp Leu Leu Ile Gly
                245                 250                 255 

Ala Val Leu Val Ala Val Gly Ala Phe Ala Val Tyr Gln Val Ser Ser
            260                 265                 270 

Lys Ile Gln Glu Arg Val Gln Asn Phe Val Asp Pro Val Ala His Tyr
        275                 280                 285 

Asp Thr Thr Gly Tyr Gln Leu Ser Gln Ser Leu Phe Gly Met Ser Trp
    290                 295                 300 

Gly Gly Val Thr Gly Thr Gly Ile Gly Gln Gly Tyr Pro Asn Met Ile
305                 310                 315                 320 

Pro Val Val His Ser Asp Phe Ile Leu Ala Ala Ile Gly Glu Glu Leu
                325                 330                 335 

Gly Leu Ile Gly Leu Ala Ala Ile Ile Val Leu Phe Gly Val Phe Val
            340                 345                 350 

Thr Arg Gly Met Arg Thr Ala Thr Leu Ala Arg Asp Ser Tyr Gly Lys
        355                 360                 365 

Leu Val Ala Ser Gly Leu Ser Met Thr Ile Met Ile Gln Ile Phe Val
    370                 375                 380 

Val Val Ala Gly Ile Ser Ser Leu Met Pro Met Thr Gly Leu Thr Thr
385                 390                 395                 400 

Pro Phe Met Ser Gln Gly Gly Ser Ser Leu Met Ala Asn Tyr Ile Leu
                405                 410                 415 

Met Ala Ile Ile Leu Arg Ile Ser Asp Ser Ala Arg Arg Pro Val Met
            420                 425                 430 

Ser Lys Gln Ala Ser Glu Val Ala Ala
        435                 440    


<210>    66
<211>    1326
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (I307V)_NCgl0043


<400>    66
atgaacacgc ttgaacgatt aaagcttcgt cgcacggaaa tgtggctgct gatacttgcc         60

acactcgttg tgtcgatcat gttcatcagc ctcgagctgg ccatgggcaa tgagttgggt        120

acccatattt tgatgctgat gggcggatat atcggtatct tcatcgtcgc gcacctagcc        180

atggcatggg tggcgccgtt tgctgatcaa atcatgctgc ctgtggtggc ggtgctcaat        240

ggcattggtt tggtgatgat ttatcgcctt gatgaggcca cgggctacag cacggtcaat        300

agccaattga tgtggacggt tgttggcgtc acgctgatgg tggctgtgtt gttgctgttg        360

cgtgattaca agtcgctttc gcgttattcc tacctcctcg gtgtggtggg catcgtgctg        420

ctggcgctgc ctctcgtgtg gccgcagcca ggcggcgtgg aagcccgcat ctggatttgg        480

cttggacctt tctccatcca gccaggtgag ttctccaaga ttttgctgct gctgttcttt        540

gctcagctgc tagccaccaa gcgtgctttg tttactgttg cgggctaccg tttcctcggc        600

atggatttcc ctcgtttgcg tgacctcgcg ccgattcttg tggtgtgggc gttggctatt        660

ttgatcatgg ctggcgccaa cgacttcggt cctgcactgc tgcttttcac taccgttttg        720

gccatggtgt acctggctac cggccgtggt tcctggctgt tgattggtgc tgtgttggtg        780

gctgtcggcg cgttcgcggt gtaccaagtt tcaagcaaga ttcaggaacg cgtgcaaaac        840

ttcgtggatc ctgtggccca ctatgacacc accggttacc agctgtccca gtccttgttt        900

ggcatgagtt ggggcggagt caccggcacc ggcattggtc agggttaccc caacatgatc        960

cctgtcgtgc actcggactt cattctcgca gccattggtg aggagcttgg tctgattggc       1020

ctggcggcca tcatcgtgct gtttggtgtg tttgtcaccc gcggtatgcg caccgctacc       1080

ctggctcgtg acagctacgg aaagctcgtg gcatctggtc tgtcgatgac catcatgatc       1140

cagattttcg tcgtcgtggc aggtatttct tcactgatgc ccatgacagg tttgaccact       1200

ccgtttatgt cccagggtgg ttcatccctg atggctaact acattctgat ggccatcatc       1260

ttgcgtattt ctgacagtgc ccgccgacct gtcatgtcca agcaagcatc ggaggtggct       1320

gcgtga                                                                  1326


<210>    67
<211>    441
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_cell division membrane protein


<400>    67
Met Asn Thr Leu Glu Arg Leu Lys Leu Arg Arg Thr Glu Met Trp Leu
  1               5                  10                  15 

Leu Ile Leu Ala Thr Leu Val Val Ser Ile Met Phe Ile Ser Leu Glu
             20                  25                  30 

Leu Ala Met Gly Asn Glu Leu Gly Thr His Ile Leu Met Leu Met Gly
         35                  40                  45 

Gly Tyr Ile Gly Ile Phe Ile Val Ala His Leu Ala Met Ala Trp Val
     50                  55                  60 

Ala Pro Phe Ala Asp Gln Ile Met Leu Pro Val Val Ala Val Leu Asn
 65                  70                  75                  80 

Gly Ile Gly Leu Val Met Ile Tyr Arg Leu Asp Glu Ala Thr Gly Tyr
                 85                  90                  95 

Ser Thr Val Asn Ser Gln Leu Met Trp Thr Val Val Gly Val Thr Leu
            100                 105                 110 

Met Val Ala Val Leu Leu Leu Leu Arg Asp Tyr Lys Ser Leu Ser Arg
        115                 120                 125 

Tyr Ser Tyr Leu Leu Gly Val Val Gly Ile Val Leu Leu Ala Leu Pro
    130                 135                 140 

Leu Val Trp Pro Gln Pro Gly Gly Val Glu Ala Arg Ile Trp Ile Trp
145                 150                 155                 160 

Leu Gly Pro Phe Ser Ile Gln Pro Gly Glu Phe Ser Lys Ile Leu Leu
                165                 170                 175 

Leu Leu Phe Phe Ala Gln Leu Leu Ala Thr Lys Arg Ala Leu Phe Thr
            180                 185                 190 

Val Ala Gly Tyr Arg Phe Leu Gly Met Asp Phe Pro Arg Leu Arg Asp
        195                 200                 205 

Leu Ala Pro Ile Leu Val Val Trp Ala Leu Ala Ile Leu Ile Met Ala
    210                 215                 220 

Gly Ala Asn Asp Phe Gly Pro Ala Leu Leu Leu Phe Thr Thr Val Leu
225                 230                 235                 240 

Ala Met Val Tyr Leu Ala Thr Gly Arg Gly Ser Trp Leu Leu Ile Gly
                245                 250                 255 

Ala Val Leu Val Ala Val Gly Ala Phe Ala Val Tyr Gln Val Ser Ser
            260                 265                 270 

Lys Ile Gln Glu Arg Val Gln Asn Phe Val Asp Pro Val Ala His Tyr
        275                 280                 285 

Asp Thr Thr Gly Tyr Gln Leu Ser Gln Ser Leu Phe Gly Met Ser Trp
    290                 295                 300 

Gly Gly Ile Thr Gly Thr Gly Ile Gly Gln Gly Tyr Pro Asn Met Ile
305                 310                 315                 320 

Pro Val Val His Ser Asp Phe Ile Leu Ala Ala Ile Gly Glu Glu Leu
                325                 330                 335 

Gly Leu Ile Gly Leu Ala Ala Ile Ile Val Leu Phe Gly Val Phe Val
            340                 345                 350 

Thr Arg Gly Met Arg Thr Ala Thr Leu Ala Arg Asp Ser Tyr Gly Lys
        355                 360                 365 

Leu Val Ala Ser Gly Leu Ser Met Thr Ile Met Ile Gln Ile Phe Val
    370                 375                 380 

Val Val Ala Gly Ile Ser Ser Leu Met Pro Met Thr Gly Leu Thr Thr
385                 390                 395                 400 

Pro Phe Met Ser Gln Gly Gly Ser Ser Leu Met Ala Asn Tyr Ile Leu
                405                 410                 415 

Met Ala Ile Ile Leu Arg Ile Ser Asp Ser Ala Arg Arg Pro Val Met
            420                 425                 430 

Ser Lys Gln Ala Ser Glu Val Ala Ala
        435                 440    


<210>    68
<211>    1326
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl0043


<400>    68
atgaacacgc ttgaacgatt aaagcttcgt cgcacggaaa tgtggctgct gatacttgcc         60

acactcgttg tgtcgatcat gttcatcagc ctcgagctgg ccatgggcaa tgagttgggt        120

acccatattt tgatgctgat gggcggatat atcggtatct tcatcgtcgc gcacctagcc        180

atggcatggg tggcgccgtt tgctgatcaa atcatgctgc ctgtggtggc ggtgctcaat        240

ggcattggtt tggtgatgat ttatcgcctt gatgaggcca cgggctacag cacggtcaat        300

agccaattga tgtggacggt tgttggcgtc acgctgatgg tggctgtgtt gttgctgttg        360

cgtgattaca agtcgctttc gcgttattcc tacctcctcg gtgtggtggg catcgtgctg        420

ctggcgctgc ctctcgtgtg gccgcagcca ggcggcgtgg aagcccgcat ctggatttgg        480

cttggacctt tctccatcca gccaggtgag ttctccaaga ttttgctgct gctgttcttt        540

gctcagctgc tagccaccaa gcgtgctttg tttactgttg cgggctaccg tttcctcggc        600

atggatttcc ctcgtttgcg tgacctcgcg ccgattcttg tggtgtgggc gttggctatt        660

ttgatcatgg ctggcgccaa cgacttcggt cctgcactgc tgcttttcac taccgttttg        720

gccatggtgt acctggctac cggccgtggt tcctggctgt tgattggtgc tgtgttggtg        780

gctgtcggcg cgttcgcggt gtaccaagtt tcaagcaaga ttcaggaacg cgtgcaaaac        840

ttcgtggatc ctgtggccca ctatgacacc accggttacc agctgtccca gtccttgttt        900

ggcatgagtt ggggcggaat caccggcacc ggcattggtc agggttaccc caacatgatc        960

cctgtcgtgc actcggactt cattctcgca gccattggtg aggagcttgg tctgattggc       1020

ctggcggcca tcatcgtgct gtttggtgtg tttgtcaccc gcggtatgcg caccgctacc       1080

ctggctcgtg acagctacgg aaagctcgtg gcatctggtc tgtcgatgac catcatgatc       1140

cagattttcg tcgtcgtggc aggtatttct tcactgatgc ccatgacagg tttgaccact       1200

ccgtttatgt cccagggtgg ttcatccctg atggctaact acattctgat ggccatcatc       1260

ttgcgtattt ctgacagtgc ccgccgacct gtcatgtcca agcaagcatc ggaggtggct       1320

gcgtga                                                                  1326



<210>    69
<211>    985
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (D676Y)_NCgl0752_amino acid


<400>    69
Met Ser Thr Gly Leu Thr Pro Pro Pro Gln Pro Ile Lys Arg Pro Pro
  1               5                  10                  15 

Lys Ala Val Thr Trp Ile Phe Ala Ile Ile Ala Leu Val Ile Leu Ile
             20                  25                  30 

Ala Pro Met Ser Val Gly Phe Tyr Thr Asp Trp Leu Trp Phe Gly Glu
         35                  40                  45 

Val Asp Phe Arg Gly Val Phe Ser Lys Val Ile Val Thr Arg Ile Val
     50                  55                  60 

Leu Phe Val Ile Phe Ala Leu Ile Ala Gly Phe Val Thr Trp Leu Ala
 65                  70                  75                  80 

Gly Tyr Phe Val Thr Lys Leu Arg Pro Asp Glu Met Ser Ala Phe Asp
                 85                  90                  95 

Thr Gln Ser Pro Val Tyr Gln Tyr Arg Gln Met Ile Glu Asn Ser Leu
            100                 105                 110 

Arg Arg Val Met Val Ile Ile Pro Ile Phe Val Ala Leu Leu Ala Gly
        115                 120                 125 

Leu Ile Gly Gln Arg Ser Trp Arg Thr Val Gln Met Trp Leu Asn Gly
    130                 135                 140 

Gln Asp Phe Gly Val Ser Asp Gln Gln Phe Gly Leu Asp Tyr Gly Phe
145                 150                 155                 160 

Tyr Ala Phe Asp Leu Pro Met Leu Arg Leu Ile Ala Asp Ser Leu Ser
                165                 170                 175 

Met Met Leu Ile Val Ala Phe Leu Ile Ala Leu Val Gly His Tyr Leu
            180                 185                 190 

Met Gly Gly Ile Arg Ala Gly Asn Gln Met Thr Gly Gln Lys Ser Phe
        195                 200                 205 

Val Ser Arg Gly Ala Arg Thr Gln Leu Ala Val Thr Ala Gly Leu Trp
    210                 215                 220 

Met Leu Val Lys Val Ala Gly Tyr Trp Leu Asp Arg Tyr Asp Leu Leu
225                 230                 235                 240 

Thr Lys Glu Asn Ser Thr Phe Thr Gly Ala Ser Tyr Thr Asp Ile Asn
                245                 250                 255 

Ala Gln Leu Pro Ala Lys Ile Ile Leu Leu Val Ile Ala Leu Phe Val
            260                 265                 270 

Ala Ile Ala Phe Phe Ser Ala Ile Phe Leu Lys Asp Leu Arg Ile Pro
        275                 280                 285 

Gly Leu Ala Val Val Leu Met Leu Leu Ser Ser Val Ile Ile Gly Ala
    290                 295                 300 

Ala Trp Pro Leu Met Leu Glu Arg Phe Ser Val Gln Pro Asn Arg Ala
305                 310                 315                 320 

Glu Lys Glu Ala Glu Tyr Ile Ser Arg Asn Ile Glu Ser Thr Arg Tyr
                325                 330                 335 

Ala Tyr Gly Ile Thr Asp Glu Asp Val Thr Tyr Glu Glu Asn Trp Gly
            340                 345                 350 

Ala Gly Glu Thr Thr Asn Glu Glu Val Ala Ala Asp Ser Ala Thr Ile
        355                 360                 365 

Ser Asn Ile Arg Leu Leu Asp Pro Gln Ile Leu Ser Pro Thr Phe Thr
    370                 375                 380 

Gln Gln Gln Gln Leu Arg Asn Phe Tyr Gly Phe Pro Asp Gln Leu Ala
385                 390                 395                 400 

Met Asp Arg Phe Glu Val Asp Gly Lys Leu Arg Asp Phe Val Val Ala
                405                 410                 415 

Ala Arg Glu Leu Asp Pro Asn Ala Leu Gln Gln Asn Gln Gln Asp Trp
            420                 425                 430 

Ile Asn Arg His Thr Val Tyr Thr His Gly Asn Gly Phe Ile Ala Ala
        435                 440                 445 

Gln Ala Asn Gln Val Asp Glu Val Ala Arg Asp Val Gly Ser Thr Arg
    450                 455                 460 

Gly Gly Tyr Pro Val Tyr Thr Val Ser Asp Leu Gln Ser Asn Ala Arg
465                 470                 475                 480 

Ala Ala Glu Ser Glu Asp Ala Glu Glu Leu Gly Ile Lys Val Asp Glu
                485                 490                 495 

Pro Arg Val Tyr Tyr Gly Pro Leu Ile Ala Ser Ala Thr Asp Gly Ala
            500                 505                 510 

Asp Tyr Ala Ile Val Gly Asp Thr Gly Asp Gly Pro Val Glu Tyr Asp
        515                 520                 525 

Thr Asp Thr Ser Ser Tyr Thr Tyr Glu Gly Ala Gly Gly Val Asp Ile
    530                 535                 540 

Gly Asn Met Val Asn Arg Ala Met Phe Ala Leu Arg Tyr Gln Glu Met
545                 550                 555                 560 

Asn Met Leu Leu Ser Asp Arg Val Gly Ser Glu Ser Lys Ile Leu Phe
                565                 570                 575 

Glu Arg Asp Pro Arg Ser Arg Val Glu Lys Val Ala Pro Trp Leu Thr
            580                 585                 590 

Thr Asp Ser Lys Thr Tyr Pro Thr Val Ile Asp Gly Arg Ile Lys Trp
        595                 600                 605 

Ile Val Asp Gly Tyr Thr Thr Leu Asp Ser Leu Pro Tyr Ser Thr Arg
    610                 615                 620 

Thr Ser Leu Thr Glu Ala Thr Gln Asp Ala Val Met Pro Asp Gly Thr
625                 630                 635                 640 

Pro Gln Pro Leu Ile Thr Asp Arg Val Gly Tyr Ile Arg Asn Ser Val
                645                 650                 655 

Lys Ala Val Val Asp Ala Tyr Asp Gly Thr Val Glu Leu Tyr Glu Phe
            660                 665                 670 

Asp Thr Glu Tyr Pro Val Leu Lys Ala Trp Arg Gly Val Phe Pro Asp
        675                 680                 685 

Thr Val Lys Asp Gly Ser Glu Ile Ser Asp Glu Leu Arg Ala His Leu
    690                 695                 700 

Arg Tyr Pro Glu Asp Leu Phe Lys Val Gln Arg Asp Met Leu Ala Lys
705                 710                 715                 720 

Tyr Asn Val Asp Asp Ser Gly Thr Phe Phe Thr Asn Asp Ala Phe Trp
                725                 730                 735 

Ser Val Pro Gly Asp Pro Thr Ala Ala Glu Gly Arg Gln Glu Leu Lys
            740                 745                 750 

Gln Pro Pro Tyr Tyr Val Val Ala Ala Asp Pro Glu Thr Gly Glu Ser
        755                 760                 765 

Ser Phe Gln Leu Ile Thr Pro Phe Arg Gly Leu Gln Arg Glu Tyr Leu
    770                 775                 780 

Ser Ala His Met Ser Ala Ser Ser Asp Pro Val Thr Tyr Gly Glu Ile
785                 790                 795                 800 

Thr Val Arg Val Leu Pro Thr Asp Ser Val Thr Gln Gly Pro Lys Gln
                805                 810                 815 

Ala Gln Asp Ala Met Met Ser Ser Asp Gln Val Ala Gln Asp Gln Thr
            820                 825                 830 

Leu Trp Arg Gly Ser Asn Asp Leu His Asn Gly Asn Leu Leu Thr Leu
        835                 840                 845 

Pro Val Gly Gly Gly Glu Ile Leu Tyr Val Glu Pro Ile Tyr Ser Gln
    850                 855                 860 

Arg Lys Asp Gln Ala Ser Ala Phe Pro Lys Leu Leu Arg Val Leu Val
865                 870                 875                 880 

Phe Tyr Lys Gly Gln Val Gly Tyr Ala Pro Thr Ile Ala Glu Ala Leu
                885                 890                 895 

Ser Gln Val Gly Ile Asp Pro Lys Glu Ala Gln Asp Ile Glu Glu Val
            900                 905                 910 

Asp Gly Thr Ala Thr Thr Pro Ser Thr Asp Glu Thr Asp Thr Asp Thr
        915                 920                 925 

Asp Gln Pro Ala Thr Glu Thr Pro Thr Ala Pro Val Ser Glu Ala Glu
    930                 935                 940 

Gly Ile Ala Ala Ile Asn Asp Ala Leu Ser Asn Leu Glu Ala Ala Arg
945                 950                 955                 960 

Asp Ser Ser Phe Glu Glu Tyr Gly Arg Ala Leu Asp Ala Leu Asp Arg
                965                 970                 975 

Ala Val Asp Ser Tyr Gln Ser Ala Gln
            980                 985


<210>    70
<211>    2958
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (D676Y)_NCgl0752_nucleic acid


<400>    70
ttgtcgactg gtctcacacc tcctccccaa ccgatcaagc gacctcccaa ggcggtgaca         60

tggatcttcg ccattatcgc gttggtcatt ctcatcgccc caatgagtgt tggcttctat        120

accgactggc tttggttcgg tgaagtcgat ttccgaggcg ttttcagcaa ggttattgtc        180

actcgcattg ttctctttgt gatctttgcg ctaattgctg ggtttgtcac atggcttgct        240

ggttattttg tgacaaaact tcgacctgat gagatgtcgg cgtttgatac ccagtcgcct        300

gtgtatcagt accgtcagat gatcgaaaac agccttcgtc gcgttatggt gatcattcca        360

attttcgtcg cgttgctggc tggcctaatt ggtcagcgtt cgtggcgcac cgttcaaatg        420

tggctgaatg gccaggactt tggcgtttcg gatcagcagt tcggcttgga ttatggattc        480

tacgcgtttg atcttccgat gcttcgcctc atcgctgact cactgtcgat gatgttgatc        540

gttgctttcc tgatcgcact cgttggccat tacctcatgg gtggcattcg cgctggaaac        600

cagatgacgg gccagaagtc ctttgtatcc cgtggtgcgc gcactcagct tgcggtaact        660

gctggtctgt ggatgcttgt taaggtcgct ggctactggc tggatcgcta tgacctgctg        720

actaaggaaa actcaacctt cacaggtgca agctacaccg acatcaatgc acagctgcca        780

gcgaagatca tcctgctggt tatcgcattg ttcgtggcga tcgcgttctt ctctgcgatc        840

ttcctgaagg acctccgcat cccaggtctt gccgtagttc tgatgctgct gagctctgtg        900

atcattggtg ctgcttggcc tttgatgctg gagcgtttct ccgttcagcc aaaccgtgca        960

gaaaaagaag ccgagtacat ttctcgaaac attgaatcga ctcgctatgc ctatggcatc       1020

accgatgaag atgtcaccta cgaggaaaac tggggagcag gggagaccac caatgaagaa       1080

gtcgccgctg attctgcaac gatttctaac attcgtctgc tggatccaca gatcctgtca       1140

ccaaccttca cccagcaaca gcagctgcga aacttctacg gtttcccaga ccagctggcg       1200

atggaccgct ttgaagtaga tggcaaactc cgcgactttg ttgtggcagc acgtgagctc       1260

gatccaaacg ccctgcagca aaaccagcag gactggatta accgtcacac tgtttatacc       1320

cacggcaacg gcttcattgc agctcaagca aaccaggtgg atgaggtcgc ccgcgacgtc       1380

ggatccactc gtggtggtta ccctgtctac accgtctctg atttgcagtc gaatgctcgt       1440

gctgcagaaa gcgaagatgc tgaggagctt ggcatcaagg ttgatgagcc tcgtgtgtac       1500

tacggaccac tgattgcttc tgcgactgat ggtgctgact acgcaattgt cggtgacacc       1560

ggcgatggcc cagtcgagta cgacactgac acctccagct acacctacga aggtgctggc       1620

ggcgtggaca ttggaaacat ggtcaaccgt gcgatgtttg cattgcgcta ccaggaaatg       1680

aacatgctcc tgtctgatcg tgttggttcc gaatccaaga tcctatttga gcgcgatcct       1740

cgttcccgtg tggaaaaggt tgcaccttgg ttgaccactg actccaagac ctacccaact       1800

gtgattgatg gtcgcatcaa gtggatcgtc gatggctaca ccaccttgga tagtcttccg       1860

tactccacgc gcacctcact gacggaagcg actcaggatg ctgtcatgcc tgacggcacc       1920

ccacagccac tgatcacaga tagggtcggt tacatccgca actccgtgaa ggctgttgtt       1980

gatgcgtacg acggaactgt tgaactctac gaattcgaca ccgaatatcc tgttctgaag       2040

gcatggcgtg gcgtgttccc agacaccgtg aaggacgggt cggagatttc cgatgagctt       2100

cgcgcacacc tgcgttaccc agaagatttg ttcaaggtcc agcgtgacat gctggccaag       2160

tacaacgttg atgattctgg aacattcttc accaacgatg cgttctggtc tgtcccaggt       2220

gacccaactg cagcggaggg ccgccaggaa cttaagcagc ctccttacta cgtggtggca       2280

gcagacccag agaccggtga gtccagcttc cagctgatca ccccgttccg tggacttcag       2340

cgcgagtacc tctctgcaca catgtctgcg tcgtctgatc cagttaccta cggtgaaatc       2400

actgttcgtg tgctgcctac cgattctgtg acccagggtc caaagcaggc ccaggatgcg       2460

atgatgtcat ctgaccaggt tgctcaggac caaacactgt ggcgtggatc gaacgatctg       2520

cacaacggaa acctgttgac cttgccagtt ggtggcggag agatcctcta cgttgagccg       2580

atttactcgc agcgcaagga tcaggcatcg gccttcccga agcttctgcg cgtgctggtc       2640

ttctacaagg gtcaggttgg ttacgcacca acgatcgctg aagccctatc gcaggtcggc       2700

attgatccga aggaagcgca ggacatcgaa gaggtagatg gcaccgctac gacgccatcg       2760

actgatgaga ctgacactga cactgatcag cctgcaaccg aaaccccaac tgcaccagtg       2820

agtgaggcgg aaggaatcgc ggccatcaac gatgcgttga gcaaccttga agctgctcgc       2880

gatagctctt tcgaagagta tggtcgtgca ctcgatgcgc ttgatcgtgc cgtcgatagc       2940

taccagtccg cacagtag                                                     2958


<210>    71
<211>    985
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl0752_amino acid


<400>    71
Met Ser Thr Gly Leu Thr Pro Pro Pro Gln Pro Ile Lys Arg Pro Pro
  1               5                  10                  15 

Lys Ala Val Thr Trp Ile Phe Ala Ile Ile Ala Leu Val Ile Leu Ile
             20                  25                  30 

Ala Pro Met Ser Val Gly Phe Tyr Thr Asp Trp Leu Trp Phe Gly Glu
         35                  40                  45 

Val Asp Phe Arg Gly Val Phe Ser Lys Val Ile Val Thr Arg Ile Val
     50                  55                  60 

Leu Phe Val Ile Phe Ala Leu Ile Ala Gly Phe Val Thr Trp Leu Ala
 65                  70                  75                  80 

Gly Tyr Phe Val Thr Lys Leu Arg Pro Asp Glu Met Ser Ala Phe Asp
                 85                  90                  95 

Thr Gln Ser Pro Val Tyr Gln Tyr Arg Gln Met Ile Glu Asn Ser Leu
            100                 105                 110 

Arg Arg Val Met Val Ile Ile Pro Ile Phe Val Ala Leu Leu Ala Gly
        115                 120                 125 

Leu Ile Gly Gln Arg Ser Trp Arg Thr Val Gln Met Trp Leu Asn Gly
    130                 135                 140 

Gln Asp Phe Gly Val Ser Asp Gln Gln Phe Gly Leu Asp Tyr Gly Phe
145                 150                 155                 160 

Tyr Ala Phe Asp Leu Pro Met Leu Arg Leu Ile Ala Asp Ser Leu Ser
                165                 170                 175 

Met Met Leu Ile Val Ala Phe Leu Ile Ala Leu Val Gly His Tyr Leu
            180                 185                 190 

Met Gly Gly Ile Arg Ala Gly Asn Gln Met Thr Gly Gln Lys Ser Phe
        195                 200                 205 

Val Ser Arg Gly Ala Arg Thr Gln Leu Ala Val Thr Ala Gly Leu Trp
    210                 215                 220 

Met Leu Val Lys Val Ala Gly Tyr Trp Leu Asp Arg Tyr Asp Leu Leu
225                 230                 235                 240 

Thr Lys Glu Asn Ser Thr Phe Thr Gly Ala Ser Tyr Thr Asp Ile Asn
                245                 250                 255 

Ala Gln Leu Pro Ala Lys Ile Ile Leu Leu Val Ile Ala Leu Phe Val
            260                 265                 270 

Ala Ile Ala Phe Phe Ser Ala Ile Phe Leu Lys Asp Leu Arg Ile Pro
        275                 280                 285 

Gly Leu Ala Val Val Leu Met Leu Leu Ser Ser Val Ile Ile Gly Ala
    290                 295                 300 

Ala Trp Pro Leu Met Leu Glu Arg Phe Ser Val Gln Pro Asn Arg Ala
305                 310                 315                 320 

Glu Lys Glu Ala Glu Tyr Ile Ser Arg Asn Ile Glu Ser Thr Arg Tyr
                325                 330                 335 

Ala Tyr Gly Ile Thr Asp Glu Asp Val Thr Tyr Glu Glu Asn Trp Gly
            340                 345                 350 

Ala Gly Glu Thr Thr Asn Glu Glu Val Ala Ala Asp Ser Ala Thr Ile
        355                 360                 365 

Ser Asn Ile Arg Leu Leu Asp Pro Gln Ile Leu Ser Pro Thr Phe Thr
    370                 375                 380 

Gln Gln Gln Gln Leu Arg Asn Phe Tyr Gly Phe Pro Asp Gln Leu Ala
385                 390                 395                 400 

Met Asp Arg Phe Glu Val Asp Gly Lys Leu Arg Asp Phe Val Val Ala
                405                 410                 415 

Ala Arg Glu Leu Asp Pro Asn Ala Leu Gln Gln Asn Gln Gln Asp Trp
            420                 425                 430 

Ile Asn Arg His Thr Val Tyr Thr His Gly Asn Gly Phe Ile Ala Ala
        435                 440                 445 

Gln Ala Asn Gln Val Asp Glu Val Ala Arg Asp Val Gly Ser Thr Arg
    450                 455                 460 

Gly Gly Tyr Pro Val Tyr Thr Val Ser Asp Leu Gln Ser Asn Ala Arg
465                 470                 475                 480 

Ala Ala Glu Ser Glu Asp Ala Glu Glu Leu Gly Ile Lys Val Asp Glu
                485                 490                 495 

Pro Arg Val Tyr Tyr Gly Pro Leu Ile Ala Ser Ala Thr Asp Gly Ala
            500                 505                 510 

Asp Tyr Ala Ile Val Gly Asp Thr Gly Asp Gly Pro Val Glu Tyr Asp
        515                 520                 525 

Thr Asp Thr Ser Ser Tyr Thr Tyr Glu Gly Ala Gly Gly Val Asp Ile
    530                 535                 540 

Gly Asn Met Val Asn Arg Ala Met Phe Ala Leu Arg Tyr Gln Glu Met
545                 550                 555                 560 

Asn Met Leu Leu Ser Asp Arg Val Gly Ser Glu Ser Lys Ile Leu Phe
                565                 570                 575 

Glu Arg Asp Pro Arg Ser Arg Val Glu Lys Val Ala Pro Trp Leu Thr
            580                 585                 590 

Thr Asp Ser Lys Thr Tyr Pro Thr Val Ile Asp Gly Arg Ile Lys Trp
        595                 600                 605 

Ile Val Asp Gly Tyr Thr Thr Leu Asp Ser Leu Pro Tyr Ser Thr Arg
    610                 615                 620 

Thr Ser Leu Thr Glu Ala Thr Gln Asp Ala Val Met Pro Asp Gly Thr
625                 630                 635                 640 

Pro Gln Pro Leu Ile Thr Asp Arg Val Gly Tyr Ile Arg Asn Ser Val
                645                 650                 655 

Lys Ala Val Val Asp Ala Tyr Asp Gly Thr Val Glu Leu Tyr Glu Phe
            660                 665                 670 

Asp Thr Glu Asp Pro Val Leu Lys Ala Trp Arg Gly Val Phe Pro Asp
        675                 680                 685 

Thr Val Lys Asp Gly Ser Glu Ile Ser Asp Glu Leu Arg Ala His Leu
    690                 695                 700 

Arg Tyr Pro Glu Asp Leu Phe Lys Val Gln Arg Asp Met Leu Ala Lys
705                 710                 715                 720 

Tyr Asn Val Asp Asp Ser Gly Thr Phe Phe Thr Asn Asp Ala Phe Trp
                725                 730                 735 

Ser Val Pro Gly Asp Pro Thr Ala Ala Glu Gly Arg Gln Glu Leu Lys
            740                 745                 750 

Gln Pro Pro Tyr Tyr Val Val Ala Ala Asp Pro Glu Thr Gly Glu Ser
        755                 760                 765 

Ser Phe Gln Leu Ile Thr Pro Phe Arg Gly Leu Gln Arg Glu Tyr Leu
    770                 775                 780 

Ser Ala His Met Ser Ala Ser Ser Asp Pro Val Thr Tyr Gly Glu Ile
785                 790                 795                 800 

Thr Val Arg Val Leu Pro Thr Asp Ser Val Thr Gln Gly Pro Lys Gln
                805                 810                 815 

Ala Gln Asp Ala Met Met Ser Ser Asp Gln Val Ala Gln Asp Gln Thr
            820                 825                 830 

Leu Trp Arg Gly Ser Asn Asp Leu His Asn Gly Asn Leu Leu Thr Leu
        835                 840                 845 

Pro Val Gly Gly Gly Glu Ile Leu Tyr Val Glu Pro Ile Tyr Ser Gln
    850                 855                 860 

Arg Lys Asp Gln Ala Ser Ala Phe Pro Lys Leu Leu Arg Val Leu Val
865                 870                 875                 880 

Phe Tyr Lys Gly Gln Val Gly Tyr Ala Pro Thr Ile Ala Glu Ala Leu
                885                 890                 895 

Ser Gln Val Gly Ile Asp Pro Lys Glu Ala Gln Asp Ile Glu Glu Val
            900                 905                 910 

Asp Gly Thr Ala Thr Thr Pro Ser Thr Asp Glu Thr Asp Thr Asp Thr
        915                 920                 925 

Asp Gln Pro Ala Thr Glu Thr Pro Thr Ala Pro Val Ser Glu Ala Glu
    930                 935                 940 

Gly Ile Ala Ala Ile Asn Asp Ala Leu Ser Asn Leu Glu Ala Ala Arg
945                 950                 955                 960 

Asp Ser Ser Phe Glu Glu Tyr Gly Arg Ala Leu Asp Ala Leu Asp Arg
                965                 970                 975 

Ala Val Asp Ser Tyr Gln Ser Ala Gln
            980                 985


<210>    72
<211>    2958
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl0752_nucleic acid


<400>    72
ttgtcgactg gtctcacacc tcctccccaa ccgatcaagc gacctcccaa ggcggtgaca         60

tggatcttcg ccattatcgc gttggtcatt ctcatcgccc caatgagtgt tggcttctat        120

accgactggc tttggttcgg tgaagtcgat ttccgaggcg ttttcagcaa ggttattgtc        180

actcgcattg ttctctttgt gatctttgcg ctaattgctg ggtttgtcac atggcttgct        240

ggttattttg tgacaaaact tcgacctgat gagatgtcgg cgtttgatac ccagtcgcct        300

gtgtatcagt accgtcagat gatcgaaaac agccttcgtc gcgttatggt gatcattcca        360

attttcgtcg cgttgctggc tggcctaatt ggtcagcgtt cgtggcgcac cgttcaaatg        420

tggctgaatg gccaggactt tggcgtttcg gatcagcagt tcggcttgga ttatggattc        480

tacgcgtttg atcttccgat gcttcgcctc atcgctgact cactgtcgat gatgttgatc        540

gttgctttcc tgatcgcact cgttggccat tacctcatgg gtggcattcg cgctggaaac        600

cagatgacgg gccagaagtc ctttgtatcc cgtggtgcgc gcactcagct tgcggtaact        660

gctggtctgt ggatgcttgt taaggtcgct ggctactggc tggatcgcta tgacctgctg        720

actaaggaaa actcaacctt cacaggtgca agctacaccg acatcaatgc acagctgcca        780

gcgaagatca tcctgctggt tatcgcattg ttcgtggcga tcgcgttctt ctctgcgatc        840

ttcctgaagg acctccgcat cccaggtctt gccgtagttc tgatgctgct gagctctgtg        900

atcattggtg ctgcttggcc tttgatgctg gagcgtttct ccgttcagcc aaaccgtgca        960

gaaaaagaag ccgagtacat ttctcgaaac attgaatcga ctcgctatgc ctatggcatc       1020

accgatgaag atgtcaccta cgaggaaaac tggggagcag gggagaccac caatgaagaa       1080

gtcgccgctg attctgcaac gatttctaac attcgtctgc tggatccaca gatcctgtca       1140

ccaaccttca cccagcaaca gcagctgcga aacttctacg gtttcccaga ccagctggcg       1200

atggaccgct ttgaagtaga tggcaaactc cgcgactttg ttgtggcagc acgtgagctc       1260

gatccaaacg ccctgcagca aaaccagcag gactggatta accgtcacac tgtttatacc       1320

cacggcaacg gcttcattgc agctcaagca aaccaggtgg atgaggtcgc ccgcgacgtc       1380

ggatccactc gtggtggtta ccctgtctac accgtctctg atttgcagtc gaatgctcgt       1440

gctgcagaaa gcgaagatgc tgaggagctt ggcatcaagg ttgatgagcc tcgtgtgtac       1500

tacggaccac tgattgcttc tgcgactgat ggtgctgact acgcaattgt cggtgacacc       1560

ggcgatggcc cagtcgagta cgacactgac acctccagct acacctacga aggtgctggc       1620

ggcgtggaca ttggaaacat ggtcaaccgt gcgatgtttg cattgcgcta ccaggaaatg       1680

aacatgctcc tgtctgatcg tgttggttcc gaatccaaga tcctatttga gcgcgatcct       1740

cgttcccgtg tggaaaaggt tgcaccttgg ttgaccactg actccaagac ctacccaact       1800

gtgattgatg gtcgcatcaa gtggatcgtc gatggctaca ccaccttgga tagtcttccg       1860

tactccacgc gcacctcact gacggaagcg actcaggatg ctgtcatgcc tgacggcacc       1920

ccacagccac tgatcacaga tagggtcggt tacatccgca actccgtgaa ggctgttgtt       1980

gatgcgtacg acggaactgt tgaactctac gaattcgaca ccgaagatcc tgttctgaag       2040

gcatggcgtg gcgtgttccc agacaccgtg aaggacgggt cggagatttc cgatgagctt       2100

cgcgcacacc tgcgttaccc agaagatttg ttcaaggtcc agcgtgacat gctggccaag       2160

tacaacgttg atgattctgg aacattcttc accaacgatg cgttctggtc tgtcccaggt       2220

gacccaactg cagcggaggg ccgccaggaa cttaagcagc ctccttacta cgtggtggca       2280

gcagacccag agaccggtga gtccagcttc cagctgatca ccccgttccg tggacttcag       2340

cgcgagtacc tctctgcaca catgtctgcg tcgtctgatc cagttaccta cggtgaaatc       2400

actgttcgtg tgctgcctac cgattctgtg acccagggtc caaagcaggc ccaggatgcg       2460

atgatgtcat ctgaccaggt tgctcaggac caaacactgt ggcgtggatc gaacgatctg       2520

cacaacggaa acctgttgac cttgccagtt ggtggcggag agatcctcta cgttgagccg       2580

atttactcgc agcgcaagga tcaggcatcg gccttcccga agcttctgcg cgtgctggtc       2640

ttctacaagg gtcaggttgg ttacgcacca acgatcgctg aagccctatc gcaggtcggc       2700

attgatccga aggaagcgca ggacatcgaa gaggtagatg gcaccgctac gacgccatcg       2760

actgatgaga ctgacactga cactgatcag cctgcaaccg aaaccccaac tgcaccagtg       2820

agtgaggcgg aaggaatcgc ggccatcaac gatgcgttga gcaaccttga agctgctcgc       2880

gatagctctt tcgaagagta tggtcgtgca ctcgatgcgc ttgatcgtgc cgtcgatagc       2940

taccagtccg cacagtag                                                     2958



<210>    73
<211>    481
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (H377Q)_major facilitator superfamily permease


<400>    73
Met Asp Ser Gln Ile Asn Thr Gln Thr Ser Pro Ala Ala Ala Lys Leu
  1               5                  10                  15 

Pro Arg Glu Val Val Val Val Leu Ser Ile Leu Val Val Ser Ala Met
             20                  25                  30 

Ile Met Ile Leu Asn Glu Thr Ile Leu Ser Val Ala Leu Pro Ser Ile
         35                  40                  45 

Met Glu Asp Phe Ser Val Pro Glu Thr Thr Ala Gln Trp Leu Thr Thr
     50                  55                  60 

Gly Phe Met Leu Thr Met Ala Val Val Ile Pro Thr Thr Gly Tyr Leu
 65                  70                  75                  80 

Leu Asp Arg Phe Ser Thr Lys Thr Ile Phe Val Thr Ala Leu Leu Phe
                 85                  90                  95 

Phe Thr Val Gly Thr Leu Thr Ala Ala Leu Ala Pro Thr Phe Ala Val
            100                 105                 110 

Leu Leu Gly Ala Arg Ile Val Gln Ala Val Gly Thr Ala Leu Val Met
        115                 120                 125 

Pro Leu Leu Met Thr Val Thr Leu Thr Val Val Pro Ala Glu Arg Arg
    130                 135                 140 

Gly Ser Met Met Gly Ile Ile Ser Ile Val Ile Ser Val Ala Pro Ala
145                 150                 155                 160 

Leu Gly Pro Thr Leu Ser Gly Val Ile Leu Asn Ser Leu Thr Trp His
                165                 170                 175 

Trp Leu Phe Trp Met Met Leu Pro Ile Val Val Ile Ala Leu Val Ile
            180                 185                 190 

Gly Phe Phe Leu Ile Lys Asn Ile Gly Glu Thr Lys Ile Thr Pro Leu
        195                 200                 205 

Asp Val Leu Ser Val Ile Leu Ser Val Phe Ala Phe Gly Gly Leu Val
    210                 215                 220 

Tyr Gly Phe Ser Ser Phe Gly Ala Ile Leu Glu Gly Glu Gly Thr Val
225                 230                 235                 240 

Gly Ile Phe Ala Ile Val Val Gly Ala Ile Ala Leu Leu Ile Phe Ala
                245                 250                 255 

Leu Arg Gln His Gln Leu Gly Lys Gln Asp Lys Ala Leu Met Asp Leu
            260                 265                 270 

Arg Ala Phe Lys Val Arg Asn Phe Ser Phe Ser Leu Thr Thr Ile Leu
        275                 280                 285 

Leu Ala Phe Gly Ala Met Leu Gly Thr Val Met Val Leu Pro Ile Tyr
    290                 295                 300 

Leu Gln Thr Ser Leu Gly Val Thr Ala Leu Val Thr Gly Leu Val Val
305                 310                 315                 320 

Met Pro Gly Gly Leu Leu Gln Gly Leu Ile Ser Pro Phe Ile Gly Arg
                325                 330                 335 

Phe Tyr Asp Lys Val Gly Pro Arg Pro Leu Leu Ile Pro Gly Ala Ile
            340                 345                 350 

Ala Leu Ala Ile Ala Ala Ser Ser Met Thr Phe Leu Asn Glu Asn Ser
        355                 360                 365 

Pro Val Trp Met Val Val Val Met Gln Val Val Phe Ser Ile Gly Met
    370                 375                 380 

Cys Leu Met Met Thr Pro Leu Met Thr Thr Ala Leu Gly Ala Leu Pro
385                 390                 395                 400 

Lys His Leu Tyr Gly His Gly Ser Ala Ile Leu Asn Thr Phe Gln Gln
                405                 410                 415 

Leu Ala Gly Ala Ala Gly Thr Ala Ile Met Ile Ala Ala Leu Ser Phe
            420                 425                 430 

Gly Thr Ser Ile Ala Ala Ser Ser Gly Ser Ala His Ala Glu Ala Val
        435                 440                 445 

Ala Ala Gly Thr Lys Val Ala Phe Ile Ala Gly Ala Ile Ile Ala Val
    450                 455                 460 

Ile Ala Leu Val Val Ser Leu Phe Val Thr Arg Val Glu Glu Glu Ala
465                 470                 475                 480 

His
   


<210>    74
<211>    1446
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (H377Q)_NCgl2592


<400>    74
atggattccc aaattaatac tcagacctct ccggcagctg cgaagctgcc tagggaggtc         60

gttgttgttc tttcgatcct cgtggtttcc gcgatgatca tgattcttaa tgaaaccatt        120

ctgtcggttg cgttgccttc catcatggaa gatttctccg tgcctgaaac tactgcacag        180

tggttgacca ctggctttat gttgacgatg gcagtggtga ttccaactac tggttatctg        240

cttgatcgtt tttccactaa gacgatcttt gttactgcgt tgttgttctt tacggttggt        300

acgttgactg cggcgttggc tccaacgttt gcggtgctgc ttggtgctcg tatcgttcag        360

gcggttggta ctgcgctggt gatgcctttg ctgatgacgg ttacgttgac ggtggttcct        420

gcggagcgtc gtggttcgat gatgggcatt atttccatcg tgatttctgt tgcgccggcg        480

cttggtccta cgttgtctgg tgtcattctt aactctttga cctggcactg gttgttttgg        540

atgatgcttc cgatcgttgt tatcgctttg gtaattggtt tcttcttgat caaaaatatc        600

ggcgaaacca agatcacccc actggatgtt ctgtctgtca tcctttcggt gtttgccttc        660

ggtggtttgg tgtacggctt cagttccttc ggagcaatcc tggagggcga aggcaccgta        720

ggtatcttcg cgatcgtcgt tggcgccatc gcactcctca tctttgcttt gcgacagcac        780

caactcggca agcaagacaa agcactgatg gatctccgag ccttcaaggt gaggaacttc        840

agcttctcct tgaccaccat ccttttggcg ttcggcgcga tgctcggaac cgtcatggtt        900

ttgccaatct acctgcagac ttccctcgga gttactgctt tggtgaccgg tttggttgtt        960

atgcccggcg gcctcctcca gggtctgatc agcccattca tcggacgttt ctacgacaag       1020

gtcggtccac gtccgctgct gattcccgga gcaattgcgc tggctatcgc ggcatcctcg       1080

atgactttcc tcaatgagaa ttcacccgtg tggatggtcg tggtcatgca agttgtgttc       1140

agcatcggca tgtgtttgat gatgacccct ctcatgacca ccgctctcgg cgcccttccg       1200

aagcacctct atggtcacgg ctccgcaatt ttgaacacgt tccaacagct cgcaggcgca       1260

gccggaacag cgatcatgat tgcagcactt tccttcggca cttccattgc agcgtcttcg       1320

ggatctgcgc atgctgaagc tgttgccgct ggtaccaagg ttgcgttcat cgcaggcgca       1380

atcatcgcgg tgatcgcttt ggttgtttcc ctcttcgtca ctcgcgtcga ggaagaagct       1440

cactaa                                                                  1446


<210>    75
<211>    481
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    (WT)_major facilitator superfamily permease


<400>    75
Met Asp Ser Gln Ile Asn Thr Gln Thr Ser Pro Ala Ala Ala Lys Leu
  1               5                  10                  15 

Pro Arg Glu Val Val Val Val Leu Ser Ile Leu Val Val Ser Ala Met
             20                  25                  30 

Ile Met Ile Leu Asn Glu Thr Ile Leu Ser Val Ala Leu Pro Ser Ile
         35                  40                  45 

Met Glu Asp Phe Ser Val Pro Glu Thr Thr Ala Gln Trp Leu Thr Thr
     50                  55                  60 

Gly Phe Met Leu Thr Met Ala Val Val Ile Pro Thr Thr Gly Tyr Leu
 65                  70                  75                  80 

Leu Asp Arg Phe Ser Thr Lys Thr Ile Phe Val Thr Ala Leu Leu Phe
                 85                  90                  95 

Phe Thr Val Gly Thr Leu Thr Ala Ala Leu Ala Pro Thr Phe Ala Val
            100                 105                 110 

Leu Leu Gly Ala Arg Ile Val Gln Ala Val Gly Thr Ala Leu Val Met
        115                 120                 125 

Pro Leu Leu Met Thr Val Thr Leu Thr Val Val Pro Ala Glu Arg Arg
    130                 135                 140 

Gly Ser Met Met Gly Ile Ile Ser Ile Val Ile Ser Val Ala Pro Ala
145                 150                 155                 160 

Leu Gly Pro Thr Leu Ser Gly Val Ile Leu Asn Ser Leu Thr Trp His
                165                 170                 175 

Trp Leu Phe Trp Met Met Leu Pro Ile Val Val Ile Ala Leu Val Ile
            180                 185                 190 

Gly Phe Phe Leu Ile Lys Asn Ile Gly Glu Thr Lys Ile Thr Pro Leu
        195                 200                 205 

Asp Val Leu Ser Val Ile Leu Ser Val Phe Ala Phe Gly Gly Leu Val
    210                 215                 220 

Tyr Gly Phe Ser Ser Phe Gly Ala Ile Leu Glu Gly Glu Gly Thr Val
225                 230                 235                 240 

Gly Ile Phe Ala Ile Val Val Gly Ala Ile Ala Leu Leu Ile Phe Ala
                245                 250                 255 

Leu Arg Gln His Gln Leu Gly Lys Gln Asp Lys Ala Leu Met Asp Leu
            260                 265                 270 

Arg Ala Phe Lys Val Arg Asn Phe Ser Phe Ser Leu Thr Thr Ile Leu
        275                 280                 285 

Leu Ala Phe Gly Ala Met Leu Gly Thr Val Met Val Leu Pro Ile Tyr
    290                 295                 300 

Leu Gln Thr Ser Leu Gly Val Thr Ala Leu Val Thr Gly Leu Val Val
305                 310                 315                 320 

Met Pro Gly Gly Leu Leu Gln Gly Leu Ile Ser Pro Phe Ile Gly Arg
                325                 330                 335 

Phe Tyr Asp Lys Val Gly Pro Arg Pro Leu Leu Ile Pro Gly Ala Ile
            340                 345                 350 

Ala Leu Ala Ile Ala Ala Ser Ser Met Thr Phe Leu Asn Glu Asn Ser
        355                 360                 365 

Pro Val Trp Met Val Val Val Met His Val Val Phe Ser Ile Gly Met
    370                 375                 380 

Cys Leu Met Met Thr Pro Leu Met Thr Thr Ala Leu Gly Ala Leu Pro
385                 390                 395                 400 

Lys His Leu Tyr Gly His Gly Ser Ala Ile Leu Asn Thr Phe Gln Gln
                405                 410                 415 

Leu Ala Gly Ala Ala Gly Thr Ala Ile Met Ile Ala Ala Leu Ser Phe
            420                 425                 430 

Gly Thr Ser Ile Ala Ala Ser Ser Gly Ser Ala His Ala Glu Ala Val
        435                 440                 445 

Ala Ala Gly Thr Lys Val Ala Phe Ile Ala Gly Ala Ile Ile Ala Val
    450                 455                 460 

Ile Ala Leu Val Val Ser Leu Phe Val Thr Arg Val Glu Glu Glu Ala
465                 470                 475                 480 

His
   


<210>    76
<211>    1446
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    (WT)_NCgl2592


<400>    76
atggattccc aaattaatac tcagacctct ccggcagctg cgaagctgcc tagggaggtc         60

gttgttgttc tttcgatcct cgtggtttcc gcgatgatca tgattcttaa tgaaaccatt        120

ctgtcggttg cgttgccttc catcatggaa gatttctccg tgcctgaaac tactgcacag        180

tggttgacca ctggctttat gttgacgatg gcagtggtga ttccaactac tggttatctg        240

cttgatcgtt tttccactaa gacgatcttt gttactgcgt tgttgttctt tacggttggt        300

acgttgactg cggcgttggc tccaacgttt gcggtgctgc ttggtgctcg tatcgttcag        360

gcggttggta ctgcgctggt gatgcctttg ctgatgacgg ttacgttgac ggtggttcct        420

gcggagcgtc gtggttcgat gatgggcatt atttccatcg tgatttctgt tgcgccggcg        480

cttggtccta cgttgtctgg tgtcattctt aactctttga cctggcactg gttgttttgg        540

atgatgcttc cgatcgttgt tatcgctttg gtaattggtt tcttcttgat caaaaatatc        600

ggcgaaacca agatcacccc actggatgtt ctgtctgtca tcctttcggt gtttgccttc        660

ggtggtttgg tgtacggctt cagttccttc ggagcaatcc tggagggcga aggcaccgta        720

ggtatcttcg cgatcgtcgt tggcgccatc gcactcctca tctttgcttt gcgacagcac        780

caactcggca agcaagacaa agcactgatg gatctccgag ccttcaaggt gaggaacttc        840

agcttctcct tgaccaccat ccttttggcg ttcggcgcga tgctcggaac cgtcatggtt        900

ttgccaatct acctgcagac ttccctcgga gttactgctt tggtgaccgg tttggttgtt        960

atgcccggcg gcctcctcca gggtctgatc agcccattca tcggacgttt ctacgacaag       1020

gtcggtccac gtccgctgct gattcccgga gcaattgcgc tggctatcgc ggcatcctcg       1080

atgactttcc tcaatgagaa ttcacccgtg tggatggtcg tggtcatgca cgttgtgttc       1140

agcatcggca tgtgtttgat gatgacccct ctcatgacca ccgctctcgg cgcccttccg       1200

aagcacctct atggtcacgg ctccgcaatt ttgaacacgt tccaacagct cgcaggcgca       1260

gccggaacag cgatcatgat tgcagcactt tccttcggca cttccattgc agcgtcttcg       1320

ggatctgcgc atgctgaagc tgttgccgct ggtaccaagg ttgcgttcat cgcaggcgca       1380

atcatcgcgg tgatcgcttt ggttgtttcc ctcttcgtca ctcgcgtcga ggaagaagct       1440

cactaa                                                                  1446


<210>    77
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2816_1F


<400>    77
tcgagctcgg tacccaagat gtacttcccc agcgg                                    35


<210>    78
<211>    41
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2816_2R


<400>    78
cggaatcgcg gatacgcttg cactcggggg tttcatcaag g                             41


<210>    79
<211>    41
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2816_3F


<400>    79
ccttgatgaa acccccgagt gcaagcgtat ccgcgattcc g                             41


<210>    80
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2816_4R


<400>    80
ctctagagga tccccgcgat aatgggtgcg gtacc                                    35


<210>    81
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2816_5F


<400>    81
aagatgtact tccccagcgg                                                     20


<210>    82
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2816_6R


<400>    82
gcgataatgg gtgcggtacc                                                     20


<210>    83
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    dnaZX_1F


<400>    83
tcgagctcgg tacccccaag agggtttttc tgtggt                                   36


<210>    84
<211>    44
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    dnaZX_2R


<400>    84
cgtcttgcca caaccacgca gacccgaaaa aaggtacgca tggt                          44


<210>    85
<211>    44
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    dnaZX_3F


<400>    85
accatgcgta ccttttttcg ggtctgcgtg gttgtggcaa gacg                          44


<210>    86
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    dnaZX_4R


<400>    86
ctctagagga tccccgccgc cgccggcgcg gatgac                                   36


<210>    87
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    dnaZX_5F


<400>    87
ccaagagggt ttttctgtgg t                                                   21


<210>    88
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    dnaZX_6R


<400>    88
gccgccgccg gcgcggatga c                                                   21


<210>    89
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl3069_1F


<400>    89
tcgagctcgg taccctgcca gccaatcaca tggga                                    35


<210>    90
<211>    41
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl3069_2R


<400>    90
ggtttggaat gttcgcagtt agtctgtgga gcacgctgta a                             41


<210>    91
<211>    41
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl3069_3F


<400>    91
ttacagcgtg ctccacagac taactgcgaa cattccaaac c                             41


<210>    92
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl3069_4R


<400>    92
ctctagagga tccccaggcc gggacactac gtgtg                                    35


<210>    93
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl3069_5F


<400>    93
tgccagccaa tcacatggga                                                     20


<210>    94
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl3069_6R


<400>    94
aggccgggac actacgtgtg                                                     20


<210>    95
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nusG_1F


<400>    95
tcgagctcgg tacccctcca gaagaagccg cagaag                                   36


<210>    96
<211>    44
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nusG_2R


<400>    96
caggagttgc attgccctcg tcacccacaa agctggtcac acca                          44


<210>    97
<211>    44
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nusG_3F


<400>    97
tggtgtgacc agctttgtgg gtgacgaggg caatgcaact cctg                          44


<210>    98
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nusG_4R


<400>    98
ctctagagga tccccctagc taaccttctc aacctg                                   36


<210>    99
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nusG_5F


<400>    99
ctccagaaga agccgcagaa g                                                   21


<210>    100
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nusG_6R


<400>    100
ctagctaacc ttctcaacct g                                                   21


<210>    101
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0636_1F


<400>    101
tcgagctcgg tacccggccc caacggatgc ggcaaa                                   36


<210>    102
<211>    44
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0636_2R


<400>    102
aagtcccaat tcgtggagca tcatgacgat ggtggtgccg tggt                          44


<210>    103
<211>    44
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0636_3F


<400>    103
accacggcac caccatcgtc atgatgctcc acgaattggg actt                          44


<210>    104
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0636_4R


<400>    104
ctctagagga tccccagtag gtgcgcatga cgccgc                                   36


<210>    105
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0636_5F


<400>    105
ggccccaacg gatgcggcaa a                                                   21


<210>    106
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0636_6R


<400>    106
agtaggtgcg catgacgccg c                                                   21


<210>    107
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2297_1F


<400>    107
tcgagctcgg taccctttgc tggctaacaa cggca                                    35


<210>    108
<211>    41
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2297_2R


<400>    108
caggaatgcc gtatgcaccg atggaaggaa ttgccgcaga g                             41


<210>    109
<211>    41
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2297_3F


<400>    109
ctctgcggca attccttcca tcggtgcata cggcattcct g                             41


<210>    110
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2297_4R


<400>    110
ctctagagga tccccaagtt ctgccatgcg acgct                                    35


<210>    111
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2297_5F


<400>    111
tttgctggct aacaacggca                                                     20


<210>    112
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2297_6R


<400>    112
aagttctgcc atgcgacgct                                                     20


<210>    113
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1540_1F


<400>    113
tcgagctcgg tacccacccg atttatcgtc gtggt                                    35


<210>    114
<211>    41
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1540_2R


<400>    114
gcaattgggt ttccgcggtc tgcgcatgtc ccgcaataat c                             41


<210>    115
<211>    41
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1540_3F


<400>    115
gattattgcg ggacatgcgc agaccgcgga aacccaattg c                             41


<210>    116
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1540_4R


<400>    116
ctctagagga tccccccacc ttgttgccac cagag                                    35


<210>    117
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1540_5F


<400>    117
acccgattta tcgtcgtggt                                                     20


<210>    118
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1540_6R


<400>    118
ccaccttgtt gccaccagag                                                     20


<210>    119
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0795_1F


<400>    119
tgaattcgag ctcggtaccc aacaaatatg tttgaaagg                                39


<210>    120
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0795_2R


<400>    120
catgaggcga acggttacct tatcaagctg tgc                                      33


<210>    121
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0795_3F


<400>    121
gcacagcttg ataaggtaac cgttcgcctc atg                                      33


<210>    122
<211>    40
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0795_4R


<400>    122
gtcgactcta gaggatcccc ttcttccagc ttgattgcca                               40


<210>    123
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0795_5F


<400>    123
aacaaatatg tttgaaagg                                                      19


<210>    124
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0795_6R


<400>    124
ttcttccagc ttgattgcca                                                     20


<210>    125
<211>    40
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1892_1F


<400>    125
tgaattcgag ctcggtaccc ttcatcctcg caggtgctgc                               40


<210>    126
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1892_2R


<400>    126
ggtacggaga cgtttttacc accgttgatg aat                                      33


<210>    127
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1892_3F


<400>    127
attcatcaac ggtggtaaaa acgtctccgt acc                                      33


<210>    128
<211>    40
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1892_4R


<400>    128
gtcgactcta gaggatcccc atgaacaatg atccattcca                               40


<210>    129
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1892_5F


<400>    129
ttcatcctcg caggtgctgc                                                     20


<210>    130
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1892_6R


<400>    130
atgaacaatg atccattcca                                                     20


<210>    131
<211>    40
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1928_1F


<400>    131
tgaattcgag ctcggtaccc tgaatctttg gtgattgttg                               40


<210>    132
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1928_2R


<400>    132
acctgcgaga tctgagagtt ggtgaaaaca gct                                      33


<210>    133
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1928_3F


<400>    133
agctgttttc accaactctc agatctcgca ggt                                      33


<210>    134
<211>    40
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1928_4R


<400>    134
gtcgactcta gaggatcccc aagtctatat gtatttcctt                               40


<210>    135
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1928_5F


<400>    135
tgaatctttg gtgattgttg                                                     20


<210>    136
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1928_6R


<400>    136
aagtctatat gtatttcctt                                                     20


<210>    137
<211>    40
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1992_1F


<400>    137
tgaattcgag ctcggtaccc tttgcgctgt cattgaatgc                               40


<210>    138
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1992_2R


<400>    138
ttggccaagc gagccatcat gttgtcgcac tcg                                      33


<210>    139
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1992_3F


<400>    139
cgagtgcgac aacatgatgg ctcgcttggc caa                                      33


<210>    140
<211>    40
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1992_4R


<400>    140
gtcgactcta gaggatcccc cagaggaatc aaacgggcaa                               40


<210>    141
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1992_5F


<400>    141
tttgcgctgt cattgaatgc                                                     20


<210>    142
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl1992_6R


<400>    142
agaggaatca aacgggcaa                                                      19


<210>    143
<211>    40
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2098_1F


<400>    143
tgaattcgag ctcggtaccc ttcgttgcga actccccagc                               40


<210>    144
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2098_2R


<400>    144
tgacgggtct tgtagcaatt ggatgcggtg aaa                                      33


<210>    145
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2098_3F


<400>    145
tttcaccgca tccaattgct acaagacccg tca                                      33


<210>    146
<211>    40
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2098_4R


<400>    146
gtcgactcta gaggatcccc agttatcttg agcgtcatgc                               40


<210>    147
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2098_5F


<400>    147
ttcgttgcga actccccagc                                                     20


<210>    148
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2098_6R


<400>    148
agttatcttg agcgtcatgc                                                     20


<210>    149
<211>    37
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0169_1F


<400>    149
tgaattcgag ctcggtaccc gcttcgccgc agatcac                                  37


<210>    150
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0169_2R


<400>    150
ctcgatcagc accttaacgg cttcgttgac gcc                                      33


<210>    151
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0169_3F


<400>    151
ggcgtcaacg aagccgttaa ggtgctgatc gag                                      33


<210>    152
<211>    38
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0169_4R


<400>    152
gtcgactcta gaggatcccc gcgctcttcg tcaagtac                                 38


<210>    153
<211>    17
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0169_5F


<400>    153
ccaggcgcga agtacac                                                        17


<210>    154
<211>    17
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0169_6R


<400>    154
cgacggggag tgaccac                                                        17


<210>    155
<211>    37
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0043_1F


<400>    155
tgaattcgag ctcggtaccc ggtgggcatc gtgctgc                                  37


<210>    156
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0043_2R


<400>    156
atgccggtgc cggtgactcc gccccaactc atg                                      33


<210>    157
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0043_3F


<400>    157
catgagttgg ggcggagtca ccggcaccgg cat                                      33


<210>    158
<211>    37
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0043_4R


<400>    158
gtcgactcta gaggatcccc ggaaaccacg tgcgttc                                  37


<210>    159
<211>    17
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0043_5F


<400>    159
cgggctacag cacggtc                                                        17


<210>    160
<211>    17
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0043_6R


<400>    160
gcgagtactt ggccacc                                                        17


<210>    161
<211>    38
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0752_1F


<400>    161
tgaattcgag ctcggtaccc gctgaggagc ttggcatc                                 38


<210>    162
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0752_2R


<400>    162
gccttcagaa caggatattc ggtgtcgaat tcg                                      33


<210>    163
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0752_3F


<400>    163
cgaattcgac accgaatatc ctgttctgaa ggc                                      33


<210>    164
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0752_4R


<400>    164
gtcgactcta gaggatcccc cgatcctctc gggctg                                   36


<210>    165
<211>    17
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0752_5F


<400>    165
ggatccactc gtggtgg                                                        17


<210>    166
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl0752_6R


<400>    166
gatgcggtgt ctctaggc                                                       18


<210>    167
<211>    38
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2592_1F


<400>    167
tgaattcgag ctcggtaccc cggtggtttg gtgtacgg                                 38


<210>    168
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2592_2R


<400>    168
cgatgctgaa cacaacttgc atgaccacga cca                                      33


<210>    169
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2592_3F


<400>    169
tggtcgtggt catgcaagtt gtgttcagca tcg                                      33


<210>    170
<211>    38
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2592_4R


<400>    170
gtcgactcta gaggatcccc cgcttaaggt gaggtggc                                 38


<210>    171
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2592_5F


<400>    171
ggatgatgct tccgatcg                                                       18


<210>    172
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    NCgl2592_6R


<400>    172
gccgacctac caacaagc                                                       18


<210>    173
<211>    5803
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    pDCM2


<400>    173
gttcgcttgc tgtccataaa accgcccagt ctagctatcg ccatgtaagc ccactgcaag         60

ctacctgctt tctctttgcg cttgcgtttt cccttgtcca gatagcccag tagctgacat        120

tcatccgggg tcagcaccgt ttctgcggac tggctttcta cgtgttccgc ttcctttagc        180

agcccttgcg ccctgagtgc ttgcggcagc gtgaagctag cttttatcgc cattcgccat        240

tcaggctgcg caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc        300

tggcgaaagg gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt        360

cacgacgttg taaaacgacg gccagtgaat tcgagctcgg tacccgggga tcctctagag        420

tcgacctgca ggcatgcaag cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat        480

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg        540

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag        600

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt        660

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg        720

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg        780

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag        840

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga        900

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct        960

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc       1020

tttctccctt cgggaagcgt ggcgctttct caatgctcac gctgtaggta tctcagttcg       1080

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc       1140

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca       1200

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag       1260

ttcttgaagt ggtggcctaa ctacggctac actagaagga cagtatttgg tatctgcgct       1320

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc       1380

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga       1440

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca       1500

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttgggg       1560

tgggcgaaga actccagcat gagatccccg cgctggagga tcatccagcc ctgatagaaa       1620

cagaagccac tggagcacct caaaaacacc atcatacact aaatcagtaa gttggcagca       1680

tcacccgacg cactttgcgc cgaataaata cctgtgacgg aagatcactt cgcagaataa       1740

ataaatcctg gtgtccctgt tgataccggg aagccctggg ccaacttttg gcgaaaatga       1800

gacgttgatc ggcacgtaag aggttccaac tttcaccata atgaaataag atcactaccg       1860

ggcgtatttt ttgagttatc gagattttca ggagctgata gaaacagaag ccactggagc       1920

acctcaaaaa caccatcata cactaaatca gtaagttggc agcatcaccc gacgcacttt       1980

gcgccgaata aatacctgtg acggaagatc acttcgcaga ataaataaat cctggtgtcc       2040

ctgttgatac cgggaagccc tgggccaact tttggcgaaa atgagacgtt gatcggcacg       2100

taagaggttc caactttcac cataatgaaa taagatcact accgggcgta ttttttgagt       2160

tatcgagatt ttcaggagct ctttggcatc gtctctcgcc tgtcccctca gttcagtaat       2220

ttcctgcatt tgcctgtttc cagtcggtag atattccaca aaacagcagg gaagcagcgc       2280

ttttccgctg cataaccctg cttcggggtc attatagcga ttttttcggt atatccatcc       2340

tttttcgcac gatatacagg attttgccaa agggttcgtg tagactttcc ttggtgtatc       2400

caacggcgtc agccgggcag gataggtgaa gtaggcccac ccgcgagcgg gtgttccttc       2460

ttcactgtcc cttattcgca cctggcggtg ctcaacggga atcctgctct gcgaggctgg       2520

ccggctaccg ccggcgtaac agatgagggc aagcggatgg ctgatgaaac caagccaacc       2580

aggaagggca gcccacctat caaggtgtac tgccttccag acgaacgaag agcgattgag       2640

gaaaaggcgg cggcggccgg catgagcctg tcggcctacc tgctggccgt cggccagggc       2700

tacaaaatca cgggcgtcgt ggactatgag cacgtccgcg agggcgtccc ggaaaacgat       2760

tccgaagccc aacctttcat agaaggcggc ggtggaatcg aaatctcgtg atggcaggtt       2820

gggcgtcgct tggtcggtca tttcgaaaaa ggttaggaat acggttagcc atttgcctgc       2880

ttttatatag ttcantatgg gattcacctt tatgttgata agaaataaaa gaaaatgcca       2940

ataggatatc ggcattttct tttgcgtttt tatttgttaa ctgttaattg tccttgttca       3000

aggatgctgt ctttgacaac agatgttttc ttgcctttga tgttcagcag gaagctcggc       3060

gcaaacgttg attgtttgtc tgcgtagaat cctctgtttg tcatatagct tgtaatcacg       3120

acattgtttc ctttcgcttg aggtacagcg aagtgtgagt aagtaaaggt tacatcgtta       3180

ggcggatcaa gatccatttt taacacaagg ccagttttgt tcagcggctt gtatgggcca       3240

gttaaagaat tagaaacata accaagcatg taaatatcgt tagacgtaat gccgtcaatc       3300

gtcatttttg atccgcggga gtcagtgaac aggtaccatt tgccgttcat tttaaagacg       3360

ttcgcgcgtt caatttcatc tgttactgtg ttagatgcaa tcagcggttt catcactttt       3420

ttcagtgtgt aatcatcgtt tagctcaatc ataccgagag cgccgtttgc taactcagcc       3480

gtgcgttttt tatcgctttg cagaagtttt tgactttctt gacggaagaa tgatgtgctt       3540

ttgccatagt atgctttgtt aaataaagat tcttcgcctt ggtagccatc ttcagttcca       3600

gtgtttgctt caaatactaa gtatttgtgg cctttatctt ctacgtagtg aggatctctc       3660

agcgtatggt tgtcgcctga gctgtagttg ccttcatcga tgaactgctg tacattttga       3720

tacgtttttc cgtcaccgtc aaagattgat ttataatcct ctacaccgtt gatgttcaaa       3780

gagctgtctg atgctgatac gttaacttgt gcagttgtca gtgtttgttt gccgtaatgt       3840

ttaccggaga aatcagtgta gaataaacgg atttttccgt cagatgtaaa tgtggctgaa       3900

cctgaccatt cttgtgtttg gtcttttagg atagaatcat ttgcatcgaa tttgtcgctg       3960

tctttaaaga cgcggccagc gtttttccag ctgtcaatag aagtttcgcc gactttttga       4020

tagaacatgt aaatcgatgt gtcatccgca tttttaggat ctccggctaa tgcaaagacg       4080

atgtggtagc cgtgatagtt tgcgacagtg ccgtcagcgt tttgtaatgg ccagctgtcc       4140

caaacgtcca ggccttttgc agaagagata tttttaattg tggacgaatc aaattcagaa       4200

acttgatatt tttcattttt ttgctgttca gggatttgca gcatatcatg gcgtgtaata       4260

tgggaaatgc cgtatgtttc cttatatggc ttttggttcg tttctttcgc aaacgcttga       4320

gttgcgcctc ctgccagcag tgcggtagta aaggttaata ctgttgcttg ttttgcaaac       4380

tttttgatgt tcatcgttca tgtctccttt tttatgtact gtgttagcgg tctgcttctt       4440

ccagccctcc tgtttgaaga tggcaagtta gttacgcaca ataaaaaaag acctaaaata       4500

tgtaaggggt gacgccaaag tatacacttt gccctttaca cattttaggt cttgcctgct       4560

ttatcagtaa caaacccgcg cgatttactt ttcgacctca ttctattaga ctctcgtttg       4620

gattgcaact ggtctatttt cctcttttgt ttgatagaaa atcataaaag gatttgcaga       4680

ctacgggcct aaagaactaa aaaatctatc tgtttctttt cattctctgt attttttata       4740

gtttctgttg catgggcata aagttgcctt tttaatcaca attcagaaaa tatcataata       4800

tctcatttca ctaaataata gtgaacggca ggtatatgtg atgggttaaa aaggatcacc       4860

ccagagtccc gctcagaaga actcgtcaag aaggcgatag aaggcgatgc gctgcgaatc       4920

gggagcggcg ataccgtaaa gcacgaggaa gcggtcagcc cattcgccgc caagctcttc       4980

agcaatatca cgggtagcca acgctatgtc ctgatagcgg tccgccacac ccagccggcc       5040

acagtcgatg aatccagaaa agcggccatt ttccaccatg atattcggca agcaggcatc       5100

gccatgggtc acgacgagat cctcgccgtc gggcatccgc gccttgagcc tggcgaacag       5160

ttcggctggc gcgagcccct gatgctcttc gtccagatca tcctgatcga caagaccggc       5220

ttccatccga gtacgtgctc gctcgatgcg atgtttcgct tggtggtcga atgggcaggt       5280

agccggatca agcgtatgca gccgccgcat tgcatcagcc atgatggata ctttctcggc       5340

aggagcaagg tgagatgaca ggagatcctg ccccggcact tcgcccaata gcagccagtc       5400

ccttcccgct tcagtgacaa cgtcgagaca gctgcgcaag gaacgcccgt cgtggccagc       5460

cacgatagcc gcgctgcctc gtcttggagt tcattcaggg caccggacag gtcggtcttg       5520

acaaaaagaa ccgggcgccc ctgcgctgac agccggaaca cggcggcatc agagcagccg       5580

attgtctgtt gtgcccagtc atagccgaat agcctctcca cccaagcggc cggagaacct       5640

gcgtgcaatc catcttgttc aatcatgcga aacgatcctc atcctgtctc ttgatcagat       5700

cttgatcccc tgcgccatca gatccttggc ggcaagaaag ccatccagtt tactttgcag       5760

ggcttcccaa ccttaccaga gggcgcccca gctggcaatt ccg                         5803