<110>    CUROGEN Technology Co., Ltd.
         Research and Business Foundation SUNGKYUNKWAN UNIVERSITY

<120>    Pharmaceutical composition for treating non-alcoholic fatty
         liver, non-alcoholic steatohepatitis, or hepatic fibrosis using
         Ssu72 protein or a polynucleotide encoding the same

<130>    PT22-5257

<150>    KR 10-2021-0013620
<151>    2021-01-29

<160>    28

<170>    KoPatentIn 3.0

<210>    1
<211>    194
<212>    PRT
<213>    Human Ssu72 protein sequence

<400>    1
Met Pro Ser Ser Pro Leu Arg Val Ala Val Val Cys Ser Ser Asn Gln
  1               5                  10                  15 

Asn Arg Ser Met Glu Ala His Asn Ile Leu Ser Lys Arg Gly Phe Ser
             20                  25                  30 

Val Arg Ser Phe Gly Thr Gly Thr His Val Lys Leu Pro Gly Pro Ala
         35                  40                  45 

Pro Asp Lys Pro Asn Val Tyr Asp Phe Lys Thr Thr Tyr Asp Gln Met
     50                  55                  60 

Tyr Asn Asp Leu Leu Arg Lys Asp Lys Glu Leu Tyr Thr Gln Asn Gly
 65                  70                  75                  80 

Ile Leu His Met Leu Asp Arg Asn Lys Arg Ile Lys Pro Arg Pro Glu
                 85                  90                  95 

Arg Phe Gln Asn Cys Lys Asp Leu Phe Asp Leu Ile Leu Thr Cys Glu
            100                 105                 110 

Glu Arg Val Tyr Asp Gln Val Val Glu Asp Leu Asn Ser Arg Glu Gln
        115                 120                 125 

Glu Thr Cys Gln Pro Val His Val Val Asn Val Asp Ile Gln Asp Asn
    130                 135                 140 

His Glu Glu Ala Thr Leu Gly Ala Phe Leu Ile Cys Glu Leu Cys Gln
145                 150                 155                 160 

Cys Ile Gln His Thr Glu Asp Met Glu Asn Glu Ile Asp Glu Leu Leu
                165                 170                 175 

Gln Glu Phe Glu Glu Lys Ser Gly Arg Thr Phe Leu His Thr Val Cys
            180                 185                 190 

Phe Tyr
       


<210>    2
<211>    585
<212>    DNA
<213>    Human Ssu72 gene sequence

<400>    2
atgccgtcgt ccccgctgcg ggtggcggtg gtgtgctcga gcaaccagaa ccggagcatg         60

gaggcgcaca acatcctcag caaacgggga ttcagcgtcc gatcctttgg aacagggact        120

cacgtgaagc ttccaggacc agctcccgac aagcccaatg tttatgattt caaaaccaca        180

tatgaccaga tgtacaatga tcttcttagg aaagacaaag aactctatac acagaatggg        240

attttacata tgctggacag aaataagaga atcaagcccc ggccagaaag attccagaac        300

tgcaaagacc tgtttgatct gatcctcact tgcgaagaga gagtgtatga ccaggtggtg        360

gaagatctga attccagaga acaggagacc tgccagcctg tgcacgtggt caatgtggac        420

atccaggaca accacgagga ggccaccctg ggggcgtttc tcatctgtga gctctgccag        480

tgtatccagc acacggaaga catggagaac gagatcgacg agctgctgca ggagttcgag        540

gagaagagtg gccgcacctt tctgcacacc gtctgcttct actga                        585


<210>    3
<211>    5989
<212>    DNA
<213>    pCMV. HA-Ssu72 plasmid

<400>    3
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg         60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg        120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc        180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt        240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata        300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc        360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc        420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt        480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt        540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca        600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg        660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc        720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg        780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca        840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccag cttaccatgg        900

cctaccccta cgacgtgccc gactacgcct ccctcggatc catgccgtcg tccccgctgc        960

gggtggcggt ggtgtgctcg agcaaccaga accggagcat ggaggcgcac aacatcctca       1020

gcaaacgggg attcagcgtc cgatcctttg gaacagggac tcacgtgaag cttccaggac       1080

cagctcccga caagcccaat gtttatgatt tcaaaaccac atatgaccag atgtacaatg       1140

atcttcttag gaaagacaaa gaactctata cacagaatgg gattttacat atgctggaca       1200

gaaataagag aatcaagccc cggccagaaa gattccagaa ctgcaaagac ctgtttgatc       1260

tgatcctcac ttgcgaagag agagtgtatg accaggtggt ggaagatctg aattccagag       1320

aacaggagac ctgccagcct gtgcacgtgg tcaatgtgga catccaggac aaccacgagg       1380

aggccaccct gggggcgttt ctcatctgtg agctctgcca gtgtatccag cacacggaag       1440

acatggagaa cgagatcgac gagctgctgc aggagttcga ggagaagagt ggccgcacct       1500

ttctgcacac cgtctgcttc tactgatcta gagggcccta ttctatagtg tcacctaaat       1560

gctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc       1620

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa       1680

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg       1740

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg       1800

ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta tccccacgcg       1860

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca       1920

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc       1980

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct       2040

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg       2100

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc       2160

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg       2220

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg       2280

aattaattct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag       2340

gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggtgtgga aagtccccag       2400

gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc       2460

cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc       2520

atggctgact aatttttttt atttatgcag aggccgaggc cgcctctgcc tctgagctat       2580

tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag ctcccgggag       2640

cttgtatatc cattttcgga tctgatcaag agacaggatg aggatcgttt cgcatgattg       2700

aacaagatgg attgcacgca ggttctccgg ccgcttgggt ggagaggcta ttcggctatg       2760

actgggcaca acagacaatc ggctgctctg atgccgccgt gttccggctg tcagcgcagg       2820

ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa ctgcaggacg       2880

aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct gtgctcgacg       2940

ttgtcactga agcgggaagg gactggctgc tattgggcga agtgccgggg caggatctcc       3000

tgtcatctca ccttgctcct gccgagaaag tatccatcat ggctgatgca atgcggcggc       3060

tgcatacgct tgatccggct acctgcccat tcgaccacca agcgaaacat cgcatcgagc       3120

gagcacgtac tcggatggaa gccggtcttg tcgatcagga tgatctggac gaagagcatc       3180

aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc gcgcatgccc gacggcgagg       3240

atctcgtcgt gacccatggc gatgcctgct tgccgaatat catggtggaa aatggccgct       3300

tttctggatt catcgactgt ggccggctgg gtgtggcgga ccgctatcag gacatagcgt       3360

tggctacccg tgatattgct gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc       3420

tttacggtat cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt       3480

tcttctgagc gggactctgg ggttcgaaat gaccgaccaa gcgacgccca acctgccatc       3540

acgagatttc gattccaccg ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg       3600

ggacgccggc tggatgatcc tccagcgcgg ggatctcatg ctggagttct tcgcccaccc       3660

caacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac       3720

aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc       3780

ttatcatgtc tgtataccgt cgacctctag ctagagcttg gcgtaatcat ggtcatagct       3840

gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag ccggaagcat       3900

aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg cgttgcgctc       3960

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg       4020

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct       4080

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt       4140

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc       4200

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga       4260

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata       4320

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac       4380

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg       4440

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc       4500

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag       4560

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt       4620

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt       4680

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg       4740

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac       4800

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca       4860

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac       4920

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac       4980

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt       5040

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt       5100

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt       5160

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc       5220

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa       5280

tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg       5340

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt       5400

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc       5460

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt       5520

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg       5580

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac       5640

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc       5700

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt       5760

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg       5820

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat attattgaag       5880

catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa       5940

acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtc                   5989


<210>    4
<211>    6456
<212>    DNA
<213>    AAV8. TBG. HA-Ssu72

<400>    4
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt         60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact        120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg        180

atcctctaga actatagcta gaattcgccc ttaagctagc aggttaattt ttaaaaagca        240

gtcaaaagtc caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat        300

ctcaggagca caaacattcc agatccaggt taatttttaa aaagcagtca aaagtccaag        360

tggcccttgg cagcatttac tctctctgtt tgctctggtt aataatctca ggagcacaaa        420

cattccagat ccggcgcgcc agggctggaa gctacctttg acatcatttc ctctgcgaat        480

gcatgtataa tttctacaga acctattaga aaggatcacc cagcctctgc ttttgtacaa        540

ctttccctta aaaaactgcc aattccactg ctgtttggcc caatagtgag aactttttcc        600

tgctgcctct tggtgctttt gcctatggcc cctattctgc ctgctgaaga cactcttgcc        660

agcatggact taaacccctc cagctctgac aatcctcttt ctcttttgtt ttacatgaag        720

ggtctggcag ccaaagcaat cactcaaagt tcaaacctta tcattttttg ctttgttcct        780

cttggccttg gttttgtaca tcagctttga aaataccatc ccagggttaa tgctggggtt        840

aatttataac taagagtgct ctagttttgc aatacaggac atgctataaa aatggaaaga        900

tgttgctttc tgagagacag ctttattgcg gtagtttatc acagttaaat tgctaacgca        960

gtcagtgctt ctgacacaac agtctcgaac ttaagctgca gaagttggtc gtgaggcact       1020

gggcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa actgggcttg       1080

tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac tgacatccac       1140

tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta aggctagagt       1200

acttaatacg actcactata ggctagcacc atggaattct tttacccata cgatgttcct       1260

gactatgcgg gctatcccta tgacgtcccg gactatgcag gatccatgcc gtcgtccccg       1320

ctgcgggtgg cggtggtgtg ctcgagcaac cagaaccgga gcatggaggc gcacaacatc       1380

ctcagcaaac ggggattcag cgtccgatcc tttggaacag ggactcacgt gaagcttcca       1440

ggaccagctc ccgacaagcc caatgtttat gatttcaaaa ccacatatga ccagatgtac       1500

aatgatcttc ttaggaaaga caaagaactc tatacacaga atgggatttt acatatgctg       1560

gacagaaata agagaatcaa gccccggcca gaaagattcc agaactgcaa agacctgttt       1620

gatctgatcc tcacttgcga agagagagtg tatgaccagg tggtggaaga tctgaattcc       1680

agagaacagg agacctgcca gcctgtgcac gtggtcaatg tggacatcca ggacaaccac       1740

gaggaggcca ccctgggggc gtttctcatc tgtgagctct gccagtgtat ccagcacacg       1800

gaagacatgg agaacgagat cgacgagctg ctgcaggagt tcgaggagaa gagtggccgc       1860

acctttctgc acaccgtctg cttctactga ggtacccgct cgaggttaac gaattccgcc       1920

cccccccccc ccccccccct ctccctcccc cccccctaac gttactggcc gaagccgctt       1980

ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc cgtcttttgg       2040

caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta ggggtctttc       2100

ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga       2160

agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga accccccacc       2220

tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg caaaggcggc       2280

acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat ggctctcctc       2340

aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta tgggatctga       2400

tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa aacgtctagg       2460

ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat atggccacaa       2520

ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg gtcgagctgg       2580

acggcgacgt aaacggccac aagttcagcg tgtctggcga gggcgagggc gatgccacct       2640

acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg ccctggccca       2700

ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc gaccacatga       2760

agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag cgcaccatct       2820

tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc       2880

tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac atcctggggc       2940

acaagctgga gtacaactac aacagccaca acgtctatat catggccgac aagcagaaga       3000

acggcatcaa ggcgaacttc aagatccgcc acaacatcga ggacggcagc gtgcagctcg       3060

ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg cccgacaacc       3120

actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc gatcacatgg       3180

tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag ctgtacaagt       3240

aagtcgaccc gggcggcctc gaggacgggg tgaactacgc ctgaggatcc gatctttttc       3300

cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact tctggctaat       3360

aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc tcactcggaa       3420

gcaattcgtt gatctgaatt tcgaccaccc ataataccca ttaccctggt agataagtag       3480

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct       3540

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt       3600

gcccgggcgg cctcagtgag cgagcgagcg cgcagcctta attaacctaa ttcactggcc       3660

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca       3720

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc       3780

caacagttgc gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg       3840

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct       3900

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta       3960

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa       4020

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct       4080

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc       4140

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg       4200

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt       4260

acaatttagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct       4320

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat       4380

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg       4440

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg       4500

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc       4560

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat       4620

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact       4680

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca       4740

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact       4800

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg       4860

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg       4920

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg       4980

aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg       5040

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag       5100

ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc       5160

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga       5220

tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat       5280

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc       5340

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag       5400

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct       5460

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac       5520

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc       5580

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg       5640

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt       5700

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt       5760

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc       5820

tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca       5880

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata       5940

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg       6000

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct       6060

ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta       6120

ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag       6180

tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga       6240

ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg       6300

caattaatgt gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg       6360

ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc       6420

atgattacgc cagatttaat taaggcctta attagg                                 6456


<210>    5
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TGF-beta forward primer


<400>    5
caccggagag ccctggata                                                      19


<210>    6
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TGF-beta reverse primer


<400>    6
caccggagag ccctggata                                                      19


<210>    7
<211>    25
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Colla1 forward primer


<400>    7
gggtctagac atgttcagct ttgtg                                               25


<210>    8
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Colla1 reverse primer


<400>    8
acccttaggc cattgtgtat gc                                                  22


<210>    9
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Fasn forward primer


<400>    9
attgcatcaa gcaagtgcag                                                     20


<210>    10
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Fasn reverse primer


<400>    10
gagccgtcaa acaggaaag                                                      19


<210>    11
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Srebp1c forward primer


<400>    11
ggcttgtcct ttgggaagc                                                      19


<210>    12
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Srebp1c reverse primer


<400>    12
cgcctatgct ggtgcaca                                                       18


<210>    13
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    ACC1 forward primer


<400>    13
ccaggccatg ttgagacgct                                                     20


<210>    14
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    ACC1 reverse primer


<400>    14
ccagccagcc tcttgactat                                                     20


<210>    15
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    PPARa forward primer


<400>    15
ggatgtcaca caatgcaatt cg                                                  22


<210>    16
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    PPARa reverse primer


<400>    16
tcacagaacg gcttcctcag gt                                                  22


<210>    17
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Pgcla forward primer


<400>    17
ccctgccatt gttaagacc                                                      19


<210>    18
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Pgcla reverse primer


<400>    18
tgctgctgtt cctgttttc                                                      19


<210>    19
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Col3a1 forward primer


<400>    19
tacacctgct cctgtgcttc                                                     20


<210>    20
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Col3a1 reverse primer


<400>    20
cattcctccc actccagact                                                     20


<210>    21
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MMP12 forward primer


<400>    21
accagagcca cactatccc                                                      19


<210>    22
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MMP12 reverse primer


<400>    22
ctcctgcctc acatcatacc                                                     20


<210>    23
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MMP13 forward primer


<400>    23
ctggcacacg cttttcctc                                                      19


<210>    24
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MMP13 reverse primer


<400>    24
atgggcagca acaataaaca ag                                                  22


<210>    25
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    SMA forward primer


<400>    25
ctgacagagg caccactgaa                                                     20


<210>    26
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    SMA reverse primer


<400>    26
catctccaga gtccagcaca                                                     20


<210>    27
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Timp forward primer


<400>    27
ctcaaagacc tatagtgctg gc                                                  22


<210>    28
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Timp reverse primer


<400>    28
caaagtgacg gctctggtag                                                     20
