                         SEQUENCE LISTING

<110>  Bayer Animal Health GmbH
 
<120>  Vaccine composition for breaking self-tolerance

<130>  211409WO

<150>  21154244.4
<151>  2021-01-29

<160>  329   

<170>  PatentIn version 3.5

<210> 1
<211> 15
<212> PRT
<213> Bacteria <prokaryote>


<220> 
<223> SEQ ID NO: 1 is the amino acid sequence of the Tetanus Toxin
      T-cell epitope p2

<400> 1
Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  

<210> 2
<211> 21
<212> PRT
<213> Bacteria <prokaryote>


<220> 
<223> SEQ ID NO: 2 is the amino acid sequence of the Tetanus Toxin
      T-cell epitope p30

<400> 2
Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      
Ala Ser His Leu Glu 
            20      

<210> 3
<211> 136
<212> PRT
<213> Canis


<220> 
<223> SEQ ID NO: 3 is the amino acid sequence of canine IL-31

<400> 3
Ser His Met Ala Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg Lys 
1               5                   10                  15      
Ile Ile Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr 
            20                  25                  30          
Gln Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu 
        35                  40                  45              
Cys Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile 
    50                  55                  60                  
Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile 
65                  70                  75                  80  
Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro 
                85                  90                  95      
Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe 
            100                 105                 110         
Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val Phe 
        115                 120                 125             
Lys Ser Leu Asn Ser Gly Pro Gln 
    130                 135     

<210> 4
<211> 507
<212> PRT
<213> Artificial Sequence


<220> 
<223> SEQ ID NO: 4 is one version of the amino acid sequence of the
      cIL-31 polyprotein used for the vaccine composition of Example 13

<400> 4
Ala Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg Lys Ile Ile Leu 
1               5                   10                  15      
Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr Gln Lys Lys 
            20                  25                  30          
Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr 
        35                  40                  45              
Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr 
    50                  55                  60                  
Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile 
65                  70                  75                  80  
Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu 
                85                  90                  95      
Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr 
            100                 105                 110         
Ile Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val Phe Lys Ser Leu 
        115                 120                 125             
Asn Ser Gly Pro Gln Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    130                 135                 140                 
Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ser His Met Ala 
145                 150                 155                 160 
Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu 
                165                 170                 175     
Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr Gln Lys Lys Glu 
            180                 185                 190         
Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr Ser 
        195                 200                 205             
Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe 
    210                 215                 220                 
Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile 
225                 230                 235                 240 
Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile 
                245                 250                 255     
Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile 
            260                 265                 270         
Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn 
        275                 280                 285             
Ser Gly Pro Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
    290                 295                 300                 
Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly 
305                 310                 315                 320 
Ser Ser His Met Ala Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg 
                325                 330                 335     
Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp 
            340                 345                 350         
Tyr Gln Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu 
        355                 360                 365             
Leu Cys Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala 
    370                 375                 380                 
Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile 
385                 390                 395                 400 
Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu 
                405                 410                 415     
Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser 
            420                 425                 430         
Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val 
        435                 440                 445             
Phe Lys Ser Leu Asn Ser Gly Pro Gln Ala Gly Ser Gly Phe Asn Asn 
    450                 455                 460                 
Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
465                 470                 475                 480 
Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
                485                 490                 495     
Gly Ile Thr Glu Leu His His His His His His 
            500                 505         

<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> SEQ ID NO: 5 is the nucleic acid sequence of the
      immunostimulatory oligonucleotide 1668-PTO

<400> 5
tccatgacgt tcctgatgct                                                20


<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> SEQ ID NO: 6 is the nucleic acid sequence of the
      immunostimulatory oligonucleotide 2006-PTO

<400> 6
tcgtcgtttt gtcgttttgt cgtt                                           24


<210> 7
<211> 7637
<212> DNA
<213> Artificial Sequence


<220> 
<223> SEQ ID NO: 7 is the nucleic acid sequence of the plasmid
      pcDNA3.4-cIL31-poly encoding the cIL-31 plyprotein construct of
      Example 1

<400> 7
gttaggcgtt ttgcgctgct tcgcgatgta cgggccagat atacgcgttg acattgatta       60

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag      120

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc      180

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga      240

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      300

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      360

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      420

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca      480

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat      540

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg      600

cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg      660

agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc cagcctccgg      720

actctagagg atcgaaccct tgaattcccg ccgccaccat gctgtctcac acaggccctt      780

ctagattcgc cctgttcctg ctgtgcagca tggaaaccct gctgagcagc cacatggccc      840

ctacacatca gctgcctcca tccgacgtgc ggaagatcat cctggaactg cagcctctga      900

gcagaggcct gctggaagat taccagaaaa aagaaaccgg cgtgcccgag agcaacagga      960

ccctgctgct gtgtctgacc agcgatagcc agcctcctag actgaacagc agcgccatcc     1020

tgccttactt cagagccatc agacccctga gcgacaagaa catcatcgac aagatcatcg     1080

agcagctgga caagctgaag ttccagcacg agcccgagac agagattagc gtgcccgccg     1140

ataccttcga gtgcaagagc ttcatcctga ccatcctgca gcagttcagc gcctgcctgg     1200

aaagcgtgtt caagagcctg aacagcggcc ctcaaggatc tggcggccag tacatcaagg     1260

ccaacagcaa gttcatcggc atcaccgagc tggccggctc tggatctcat atggctccaa     1320

ctcaccagct gccacctagt gatgtgcgca agattattct cgagctgcag cccctgtcta     1380

ggggcctgct tgaggactat caaaagaaag agacaggcgt ccccgagtcc aatcgcacac     1440

tgctgctttg cctgacatcc gacagccagc cacctcggct gaatagctct gccattctgc     1500

cctactttcg ggccattagg cccctgtccg ataagaatat cattgataag attattgaac     1560

agctcgataa gctcaaattt cagcacgaac cggaaaccga gatctccgtg cctgccgaca     1620

catttgaatg caagtctttt atcctcacga ttctccagca gttttccgcc tgtctggaat     1680

ccgtgtttaa gtccctgaat agcggacccc aggccggcag cggcttcaac aatttcaccg     1740

tgtccttttg gctgcgggtg cccaaagtgt ctgccagcca tcttgagtct ggcggcagct     1800

cacacatggc acccactcat caactcccac cttcagatgt gcggaaaatc atacttgagc     1860

tgcaaccact gagccgggga ctgttggagg attaccaaaa gaaagaaact ggggtcccag     1920

aaagcaatcg gactctgctc ctgtgcctca cctccgactc tcagcctcca aggctcaact     1980

cctccgctat cctgccatat ttccgggcca tccggcctct gtctgacaaa aacattattg     2040

acaaaattat cgaacaactt gacaaactca agtttcaaca tgagcccgaa accgaaattt     2100

ctgtgcccgc tgacactttt gagtgtaaat ccttcattct cacgatcctg caacaattct     2160

ctgcctgcct cgagtctgtg ttcaagtctc tgaactcagg ccctcaggcc ggctccgggt     2220

ttaacaactt tacagtgtct ttctggctca gagtccccaa ggtgtccgcc tctcaccttg     2280

aaggttccgg cggacagtat attaaggcta actctaagtt tatcgggatt acagagctgc     2340

accaccacca tcaccactga taagcttaag ggttcgatcc ctaccggtta gtaatgagtt     2400

tgatatctcg acaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt     2460

aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct     2520

attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt     2580

tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac     2640

gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct     2700

ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca     2760

ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaagct gacgtccttt     2820

ccatggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc     2880

ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct     2940

cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg     3000

cctggaaacg ggggaggcta actgaaacac ggaaggagac aataccggaa ggaacccgcg     3060

ctatgacggc aataaaaaga cagaataaaa cgcacgggtg ttgggtcgtt tgttcataaa     3120

cgcggggttc ggtcccaggg ctggcactct gtcgataccc caccgagacc ccattggggc     3180

caatacgccc gcgtttcttc cttttcccca ccccaccccc caagttcggg tgaaggccca     3240

gggctcgcag ccaacgtcgg ggcggcaggc cctgccatag cagatctgcg cagctggggc     3300

tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     3360

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     3420

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg gggcatccct     3480

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     3540

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     3600

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     3660

tattcttttg atttataagg gattttgggg atttcggcct attggttaaa aaatgagctg     3720

atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa     3780

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     3840

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     3900

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     3960

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     4020

ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     4080

tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat     4140

gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc aggttctccg gccgcttggg     4200

tggagaggct attcggctat gactgggcac aacagacaat cggctgctct gatgccgccg     4260

tgttccggct gtcagcgcag gggcgcccgg ttctttttgt caagaccgac ctgtccggtg     4320

ccctgaatga actgcaggac gaggcagcgc ggctatcgtg gctggccacg acgggcgttc     4380

cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag ggactggctg ctattgggcg     4440

aagtgccggg gcaggatctc ctgtcatctc accttgctcc tgccgagaaa gtatccatca     4500

tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc tacctgccca ttcgaccacc     4560

aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga agccggtctt gtcgatcagg     4620

atgatctgga cgaagagcat caggggctcg cgccagccga actgttcgcc aggctcaagg     4680

cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata     4740

tcatggtgga aaatggccgc ttttctggat tcatcgactg tggccggctg ggtgtggcgg     4800

accgctatca ggacatagcg ttggctaccc gtgatattgc tgaagagctt ggcggcgaat     4860

gggctgaccg cttcctcgtg ctttacggta tcgccgctcc cgattcgcag cgcatcgcct     4920

tctatcgcct tcttgacgag ttcttctgag cgggactctg gggttcgcga aatgaccgac     4980

caagcgacgc ccaacctgcc atcacgagat ttcgattcca ccgccgcctt ctatgaaagg     5040

ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga tcctccagcg cggggatctc     5100

atgctggagt tcttcgccca ccccaacttg tttattgcag cttataatgg ttacaaataa     5160

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt     5220

ttgtccaaac tcatcaatgt atcttatcat gtctgtatac cgtcgacctc tagctagagc     5280

ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     5340

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     5400

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     5460

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     5520

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     5580

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     5640

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     5700

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     5760

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     5820

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     5880

gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     5940

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     6000

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     6060

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     6120

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc     6180

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     6240

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     6300

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     6360

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     6420

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     6480

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     6540

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac     6600

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     6660

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     6720

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     6780

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     6840

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     6900

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     6960

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     7020

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     7080

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     7140

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     7200

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     7260

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     7320

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     7380

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     7440

ccacctgacg tcgacggatc gggagatctc ccgatcccct atggtcgact ctcagtacaa     7500

tctgctctga tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg     7560

ctgagtagtg cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca     7620

tgaagaatct gcttagg                                                    7637


<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 8
Tyr Tyr Asp Ile Asn 
1               5   

<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 9
Ser Tyr Asp Met Ser 
1               5   

<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 10
Asn Tyr Gly Met Ser 
1               5   

<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 11
Trp Ile Phe Pro Gly Asp Gly Gly Thr Lys Tyr Asn Glu Thr Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 12
Thr Ile Thr Ser Gly Gly Gly Tyr Thr Tyr Ser Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 13
Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile Lys 
1               5                   10                  15      
Gly 
    

<210> 14
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 14
Ala Arg Gly Gly Thr Ser Val Ile Arg Asp Ala Met Asp Tyr 
1               5                   10                  

<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 15
Ala Arg Gln Asn Trp Val Val Gly Leu Ala Tyr 
1               5                   10      

<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 16
Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr 
1               5                   10      

<210> 17
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 17
Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  

<210> 18
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 18
Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 19
Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr Gly Leu Met His 
1               5                   10                  15  

<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 20
Arg Ala Ser Asn Leu Glu Ser 
1               5           

<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 21
Gly Ala Ser Thr Arg Glu Ser 
1               5           

<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 22
Arg Ala Ser Asn Leu Glu Ala 
1               5           

<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 23
Gln Gln Ser Asn Lys Asp Pro Leu Thr 
1               5                   

<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 24
Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   

<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 25
Gln Gln Ser Arg Glu Tyr Pro Trp Thr 
1               5                   

<210> 26
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 26
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Trp Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
65                  70                  75                  80  
Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Lys Asp 
                85                  90                  95      
Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 

<210> 27
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 27
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Trp Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val 
65                  70                  75                  80  
Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Ser Asn Lys Asp 
                85                  90                  95      
Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 

<210> 28
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 28
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              
Gln Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  
Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      
Lys Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 29
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 29
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      
Asp Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Trp Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 30
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 30
Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 31
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 31
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          
Gly Thr Gly Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      
Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 32
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 32
Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          
Gly Thr Gly Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Lys Trp Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu 
65                  70                  75                  80  
Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr 
                85                  90                  95      
Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 

<210> 33
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 33
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Tyr Tyr 
            20                  25                  30          
Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Phe Pro Gly Asp Gly Gly Thr Lys Tyr Asn Glu Thr Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Gly Thr Ser Val Ile Arg Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     

<210> 34
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 34
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Lys Tyr Tyr 
            20                  25                  30          
Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              
Gly Trp Ile Phe Pro Gly Asp Gly Gly Thr Lys Tyr Asn Glu Thr Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Thr Ser Val Ile Arg Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 35
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 35
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          
Asp Met Ser Trp Val Arg Gln Ile Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Thr Ser Gly Gly Gly Tyr Thr Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gln Asn Trp Val Val Gly Leu Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala 
        115             

<210> 36
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 36
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              
Ala Thr Ile Thr Ser Gly Gly Gly Tyr Thr Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gln Asn Trp Val Val Gly Leu Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 37
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210> 38
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence related to the labeled neutralizing antibody suitable
      for the assay of the invention (cf. WO2013/011407 A1)

<400> 38
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Val Val Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 39
<211> 12
<212> PRT
<213> Bacteria <prokaryote>


<220> 
<223> SEQ ID NO: 39 is the amino acid sequence of the Tetanus Toxin
      T-cell epitope p4

<400> 39
Gly Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu 
1               5                   10          

<210> 40
<211> 510
<212> PRT
<213> Artificial Sequence


<220> 
<223> SEQ ID NO: 40 is another version of the amino acid sequence of
      the cIL-31 polyprotein used for the vaccine of Example 13

<400> 40
Ser His Met Ala Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg Lys 
1               5                   10                  15      
Ile Ile Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr 
            20                  25                  30          
Gln Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu 
        35                  40                  45              
Cys Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile 
    50                  55                  60                  
Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile 
65                  70                  75                  80  
Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro 
                85                  90                  95      
Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe 
            100                 105                 110         
Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val Phe 
        115                 120                 125             
Lys Ser Leu Asn Ser Gly Pro Gln Gly Ser Gly Gly Gln Tyr Ile Lys 
    130                 135                 140                 
Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ser 
145                 150                 155                 160 
His Met Ala Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg Lys Ile 
                165                 170                 175     
Ile Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr Gln 
            180                 185                 190         
Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys 
        195                 200                 205             
Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu 
    210                 215                 220                 
Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp 
225                 230                 235                 240 
Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu 
                245                 250                 255     
Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile 
            260                 265                 270         
Leu Thr Ile Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val Phe Lys 
        275                 280                 285             
Ser Leu Asn Ser Gly Pro Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr 
    290                 295                 300                 
Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
305                 310                 315                 320 
Ser Gly Gly Ser Ser His Met Ala Pro Thr His Gln Leu Pro Pro Ser 
                325                 330                 335     
Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu 
            340                 345                 350         
Leu Glu Asp Tyr Gln Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg 
        355                 360                 365             
Thr Leu Leu Leu Cys Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn 
    370                 375                 380                 
Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp 
385                 390                 395                 400 
Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe 
                405                 410                 415     
Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu 
            420                 425                 430         
Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Cys Leu 
        435                 440                 445             
Glu Ser Val Phe Lys Ser Leu Asn Ser Gly Pro Gln Ala Gly Ser Gly 
    450                 455                 460                 
Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
465                 470                 475                 480 
Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
                485                 490                 495     
Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
            500                 505                 510 

<210>  41
<211>  115
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  SEQ ID NO: 41 is the amino acid sequence of canine IL-5 protein.

<400>  41

Phe Ala Val Glu Asn Pro Met Asn Arg Leu Val Ala Glu Thr Leu Thr 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Trp Leu Ile Gly Asp Gly Asn Leu Met 
            20                  25                  30          


Ile Pro Thr Pro Glu Asn Lys Asn His Gln Leu Cys Ile Lys Glu Val 
        35                  40                  45              


Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln Thr Ala His Gly Glu Ala 
    50                  55                  60                  


Val Asp Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Glu His Ile Glu 
65                  70                  75                  80  


Arg Gln Lys Lys Arg Cys Ala Gly Glu Arg Trp Arg Val Thr Lys Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Val Phe Leu Gly Val Ile Asn Thr Glu Trp Thr 
            100                 105                 110         


Pro Glu Ser 
        115 


<210>  42
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 42 is the amino acid sequence of the cIL-5 polyprotein
       used for the vaccine construct of Example 13b.

<400>  42

Val Glu Asn Pro Met Asn Arg Leu Val Ala Glu Thr Leu Thr Leu Leu 
1               5                   10                  15      


Ser Thr His Arg Thr Trp Leu Ile Gly Asp Gly Asn Leu Met Ile Pro 
            20                  25                  30          


Thr Pro Glu Asn Lys Asn His Gln Leu Cys Ile Lys Glu Val Phe Gln 
        35                  40                  45              


Gly Ile Asp Thr Leu Lys Asn Gln Thr Ala His Gly Glu Ala Val Asp 
    50                  55                  60                  


Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Glu His Ile Glu Arg Gln 
65                  70                  75                  80  


Lys Lys Arg Cys Ala Gly Glu Arg Trp Arg Val Thr Lys Phe Leu Asp 
                85                  90                  95      


Tyr Leu Gln Val Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Pro Glu 
            100                 105                 110         


Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
        115                 120                 125             


Ile Thr Glu Leu Ala Gly Ser Gly Phe Ala Val Glu Asn Pro Met Asn 
    130                 135                 140                 


Arg Leu Val Ala Glu Thr Leu Thr Leu Leu Ser Thr His Arg Thr Trp 
145                 150                 155                 160 


Leu Ile Gly Asp Gly Asn Leu Met Ile Pro Thr Pro Glu Asn Lys Asn 
                165                 170                 175     


His Gln Leu Cys Ile Lys Glu Val Phe Gln Gly Ile Asp Thr Leu Lys 
            180                 185                 190         


Asn Gln Thr Ala His Gly Glu Ala Val Asp Lys Leu Phe Gln Asn Leu 
        195                 200                 205             


Ser Leu Ile Lys Glu His Ile Glu Arg Gln Lys Lys Arg Cys Ala Gly 
    210                 215                 220                 


Glu Arg Trp Arg Val Thr Lys Phe Leu Asp Tyr Leu Gln Val Phe Leu 
225                 230                 235                 240 


Gly Val Ile Asn Thr Glu Trp Thr Pro Glu Ser Ala Gly Ser Gly Phe 
                245                 250                 255     


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
            260                 265                 270         


Ser His Leu Glu Ser Gly Gly Ser Phe Ala Val Glu Asn Pro Met Asn 
        275                 280                 285             


Arg Leu Val Ala Glu Thr Leu Thr Leu Leu Ser Thr His Arg Thr Trp 
    290                 295                 300                 


Leu Ile Gly Asp Gly Asn Leu Met Ile Pro Thr Pro Glu Asn Lys Asn 
305                 310                 315                 320 


His Gln Leu Cys Ile Lys Glu Val Phe Gln Gly Ile Asp Thr Leu Lys 
                325                 330                 335     


Asn Gln Thr Ala His Gly Glu Ala Val Asp Lys Leu Phe Gln Asn Leu 
            340                 345                 350         


Ser Leu Ile Lys Glu His Ile Glu Arg Gln Lys Lys Arg Cys Ala Gly 
        355                 360                 365             


Glu Arg Trp Arg Val Thr Lys Phe Leu Asp Tyr Leu Gln Val Phe Leu 
    370                 375                 380                 


Gly Val Ile Asn Thr Glu Trp Thr Pro Glu Ser Ala Gly Ser Gly Phe 
385                 390                 395                 400 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
                405                 410                 415     


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
            420                 425                 430         


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
        435                 440                 445 


<210>  43
<211>  447
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 43 is an alternative amino acid sequence of the cIL-5 
       polyprotein that can be used for the vaccine construct of Example
       13b.

<400>  43

Phe Ala Val Glu Asn Pro Met Asn Arg Leu Val Ala Glu Thr Leu Thr 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Trp Leu Ile Gly Asp Gly Asn Leu Met 
            20                  25                  30          


Ile Pro Thr Pro Glu Asn Lys Asn His Gln Leu Cys Ile Lys Glu Val 
        35                  40                  45              


Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln Thr Ala His Gly Glu Ala 
    50                  55                  60                  


Val Asp Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Glu His Ile Glu 
65                  70                  75                  80  


Arg Gln Lys Lys Arg Cys Ala Gly Glu Arg Trp Arg Val Thr Lys Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Val Phe Leu Gly Val Ile Asn Thr Glu Trp Thr 
            100                 105                 110         


Pro Glu Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
        115                 120                 125             


Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Phe Ala Val Glu Asn Pro 
    130                 135                 140                 


Met Asn Arg Leu Val Ala Glu Thr Leu Thr Leu Leu Ser Thr His Arg 
145                 150                 155                 160 


Thr Trp Leu Ile Gly Asp Gly Asn Leu Met Ile Pro Thr Pro Glu Asn 
                165                 170                 175     


Lys Asn His Gln Leu Cys Ile Lys Glu Val Phe Gln Gly Ile Asp Thr 
            180                 185                 190         


Leu Lys Asn Gln Thr Ala His Gly Glu Ala Val Asp Lys Leu Phe Gln 
        195                 200                 205             


Asn Leu Ser Leu Ile Lys Glu His Ile Glu Arg Gln Lys Lys Arg Cys 
    210                 215                 220                 


Ala Gly Glu Arg Trp Arg Val Thr Lys Phe Leu Asp Tyr Leu Gln Val 
225                 230                 235                 240 


Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Pro Glu Ser Ala Gly Ser 
                245                 250                 255     


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
            260                 265                 270         


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Phe Ala Val Glu Asn Pro 
        275                 280                 285             


Met Asn Arg Leu Val Ala Glu Thr Leu Thr Leu Leu Ser Thr His Arg 
    290                 295                 300                 


Thr Trp Leu Ile Gly Asp Gly Asn Leu Met Ile Pro Thr Pro Glu Asn 
305                 310                 315                 320 


Lys Asn His Gln Leu Cys Ile Lys Glu Val Phe Gln Gly Ile Asp Thr 
                325                 330                 335     


Leu Lys Asn Gln Thr Ala His Gly Glu Ala Val Asp Lys Leu Phe Gln 
            340                 345                 350         


Asn Leu Ser Leu Ile Lys Glu His Ile Glu Arg Gln Lys Lys Arg Cys 
        355                 360                 365             


Ala Gly Glu Arg Trp Arg Val Thr Lys Phe Leu Asp Tyr Leu Gln Val 
    370                 375                 380                 


Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Pro Glu Ser Ala Gly Ser 
385                 390                 395                 400 


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
                405                 410                 415     


Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
            420                 425                 430         


Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
        435                 440                 445         


<210>  44
<211>  1419
<212>  DNA
<213>  Canis lupus familiaris

<220>
<223>  SEQ ID NO: 44 is the nucleic acid sequence of the plasmid 
pcDNA3.4-cIL-5-poly encoding the cIL-5 polyprotein construct of Example 1b.

<400>  44
gaattcccgc cgccaccatg ggatggagct gcatcatcct gttcctggtc gctacagcca       60

ccggcgtgca cagcgtggaa aaccccatga atagactggt ggccgaaacc ttgacactcc      120

tgagcaccca cagaacatgg ctgatcggcg acggaaacct gatgattcct acccctgaga      180

acaagaacca ccagctgtgt atcaaggagg tgttccaggg catagacaca ctgaagaatc      240

agaccgctca cggcgaggcc gtggataagc tgttccaaaa tttaagcctg atcaaggagc      300

acatcgagag acagaagaaa agatgcgccg gcgagagatg gagagtgacc aagttcctgg      360

actacctgca agtgttcctg ggagttatca ataccgagtg gacccctgaa tccggcagcg      420

gcggccagta catcaaggcc aatagcaagt tcatcggcat tacagaactg gccggcagcg      480

gcttcgccgt cgagaaccct atgaaccgcc tggtggctga aaccctgacc ctgctctcta      540

cccacagaac ctggctgatc ggcgacggca acctgatgat cccaacacca gagaacaaga      600

accaccagct gtgcattaaa gaggtgttcc agggtatcga taccctgaaa aaccagacag      660

cccatggaga agccgtggac aagctgttcc aaaacctgtc cctgatcaaa gaacacatcg      720

agcggcagaa aaaaagatgt gccggagaga ggtggcgggt caccaagttc ctggattacc      780

tgcaggtgtt tctgggcgtg atcaacacgg agtggacacc tgagagcgct ggcagcggct      840

ttaacaactt caccgtgtcc ttttggctga gagttcctaa ggtgtccgcc agccacctgg      900

aaagcggcgg atcttttgcc gtggaaaatc ccatgaaccg gctggtggcc gagaccctga      960

cactgctgtc tacacaccgg acctggctga tcggcgatgg caatctgatg atccccacac     1020

ctgagaacaa gaaccaccag ctgtgcatca aggaagtgtt ccagggcatc gacaccctta     1080

agaaccagac cgcccacggc gaggctgtgg acaagctgtt ccagaacctg tctctgatca     1140

aggaacacat cgagcggcag aagaagcggt gcgccggcga aagatggaga gtgacaaagt     1200

tcctggacta tctgcaggtg ttcctgggcg ttatcaacac cgagtggacc cctgagagcg     1260

ccggcagcgg tttcaacaac ttcaccgtga gcttctggct tagagtgccc aaggtgtctg     1320

catctcacct ggaaggcagc ggaggccagt acatcaaagc caacagcaag tttatcggca     1380

tcaccgagct gcaccatcat caccaccact gataagctt                            1419


<210>  45
<211>  441
<212>  DNA
<213>  Canis lupus familiaris

<220>
<223>  SEQ ID NO: 45 is the nucleic acid sequence of the plasmid 
pcDNA3.4-cIL-5 encoding the cIL-5 protein construct of Example 3b.

<400>  45
gaattcccgc cgccaccatg ggctggtcct gcatcatcct gttcctggtc gccaccgcca       60

caggcgtgca cagcgtggaa aatcctatga acagactggt ggctgaaacc ctcaccctgc      120

tgagcacaca cagaacctgg ctgatcggcg acggcaacct gatgatcccc acccctgaga      180

acaagaatca ccagctgtgt atcaaagagg tgttccaagg catcgacacc ctgaagaacc      240

agacagccca cggcgaggcc gtggacaagc tgtttcagaa cctgtctctg attaaggaac      300

acatcgagag acagaaaaag cggtgcgccg gagaaagatg gcgggtgaca aagttcctgg      360

attacctgca ggtgttcctg ggagtgatca acaccgagtg gaccccagag agccaccacc      420

accaccatca ctgataagct t                                                441


<210>  46
<211>  113
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  SEQ ID NO: 46 is the amino acid sequence of canine IL-13.

<400>  46

Ser Pro Ser Pro Val Thr Pro Ser Pro Thr Leu Lys Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Ala Ser Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Val Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Asp Cys Ser Ala Ile Gln Arg Thr Gln 
    50                  55                  60                  


Arg Met Leu Lys Ala Leu Cys Ser Gln Lys Pro Ala Ala Gly Gln Ile 
65                  70                  75                  80  


Ser Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile Gln Leu Val 
                85                  90                  95      


Lys Asn Leu Leu Thr Tyr Val Arg Gly Val Tyr Arg His Gly Asn Phe 
            100                 105                 110         


Arg 
    


<210>  47
<211>  441
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 47 is the amino acid sequence of the cIL-13 
       polyprotein used for the vaccine construct of Example 13c.

<400>  47

Ser Pro Ser Pro Val Thr Pro Ser Pro Thr Leu Lys Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Ala Ser Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Val Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Asp Cys Ser Ala Ile Gln Arg Thr Gln 
    50                  55                  60                  


Arg Met Leu Lys Ala Leu Cys Ser Gln Lys Pro Ala Ala Gly Gln Ile 
65                  70                  75                  80  


Ser Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile Gln Leu Val 
                85                  90                  95      


Lys Asn Leu Leu Thr Tyr Val Arg Gly Val Tyr Arg His Gly Asn Phe 
            100                 105                 110         


Arg Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
        115                 120                 125             


Ile Thr Glu Leu Ala Gly Ser Gly Ser Pro Ser Pro Val Thr Pro Ser 
    130                 135                 140                 


Pro Thr Leu Lys Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn 
145                 150                 155                 160 


Gln Ala Ser Leu Cys Asn Gly Ser Met Val Trp Ser Val Asn Leu Thr 
                165                 170                 175     


Ala Gly Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Asp 
            180                 185                 190         


Cys Ser Ala Ile Gln Arg Thr Gln Arg Met Leu Lys Ala Leu Cys Ser 
        195                 200                 205             


Gln Lys Pro Ala Ala Gly Gln Ile Ser Ser Glu Arg Ser Arg Asp Thr 
    210                 215                 220                 


Lys Ile Glu Val Ile Gln Leu Val Lys Asn Leu Leu Thr Tyr Val Arg 
225                 230                 235                 240 


Gly Val Tyr Arg His Gly Asn Phe Arg Ala Gly Ser Gly Phe Asn Asn 
                245                 250                 255     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            260                 265                 270         


Leu Glu Ser Gly Gly Ser Ser Pro Ser Pro Val Thr Pro Ser Pro Thr 
        275                 280                 285             


Leu Lys Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Ala 
    290                 295                 300                 


Ser Leu Cys Asn Gly Ser Met Val Trp Ser Val Asn Leu Thr Ala Gly 
305                 310                 315                 320 


Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Asp Cys Ser 
                325                 330                 335     


Ala Ile Gln Arg Thr Gln Arg Met Leu Lys Ala Leu Cys Ser Gln Lys 
            340                 345                 350         


Pro Ala Ala Gly Gln Ile Ser Ser Glu Arg Ser Arg Asp Thr Lys Ile 
        355                 360                 365             


Glu Val Ile Gln Leu Val Lys Asn Leu Leu Thr Tyr Val Arg Gly Val 
    370                 375                 380                 


Tyr Arg His Gly Asn Phe Arg Ala Gly Ser Gly Phe Asn Asn Phe Thr 
385                 390                 395                 400 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
                405                 410                 415     


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
            420                 425                 430         


Thr Glu Leu His His His His His His 
        435                 440     


<210>  48
<211>  1407
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 48 is the nucleic acid sequence of the plasmid 
       pcDNA3.4-cIL-13-poly encoding the cIL-13 polyprotein construct of
       Example 1c.

<400>  48
gaattcccgc cgccaccatg ggctggtcct gcatcatcct gttcctggtc gccacagcca       60

ccggcgtgca cagcagccca tctcctgtga cccctagccc taccctgaag gagctgatcg      120

aggaactggt gaatatcacc cagaaccagg cctctctgtg caacggcagc atggtgtggt      180

ccgtgaacct gacagccgga atgtactgcg ccgccctgga aagcctgatc aacgtgtcag      240

attgcagcgc catccaaaga acacagagaa tgctgaaagc cctgtgctct cagaagcctg      300

ctgccgggca gatcagctct gagagaagcc gggacacaaa aatcgaggtg atccagctgg      360

tgaagaacct gctgacctac gttagaggcg tgtacagaca cggcaacttc cggggctctg      420

gaggacagta catcaaggca aatagcaagt tcatcggcat cacagagctg gccggcagcg      480

gctctccttc acccgtgacc cctagcccta ctctgaagga actcattgag gaactggtga      540

atatcacaca aaatcaagcc agcctgtgta acggctccat ggtctggagt gtgaacctga      600

ccgctggcat gtactgcgcc gctctggaat ctctgatcaa cgtgtccgac tgcagcgcca      660

tccagcgaac ccagagaatg ctgaaggctc tgtgttccca gaaacctgcc gccggccaga      720

tcagcagcga gagaagcaga gatacaaaga tcgaggtgat ccagctggtg aagaacctgc      780

tgacctacgt gcggggcgtg tacagacacg gaaactttcg ggccggcagc ggatttaaca      840

acttcaccgt gtccttctgg ctgagagtgc ctaaggtgtc tgcttctcac ctggaaagcg      900

gaggctccag cccatctcct gtgacaccca gccccaccct gaaagagctg atcgaagagc      960

tggtgaacat cacccagaat caggccagcc tgtgcaacgg cagcatggtg tggagcgtga     1020

acctgacagc cggaatgtat tgtgccgctc tggagagcct gattaacgtg agcgactgca     1080

gcgctatcca gagaacccag cggatgctga aagccctgtg ttctcagaag cccgccgccg     1140

gccagatcag cagcgagcgg agccgcgaca ccaagatcga ggtgatccaa ctggtcaaga     1200

atctcctgac ctacgtgagg ggcgtttacc ggcacggcaa cttcagagcc ggcagcggct     1260

tcaacaactt caccgtgtct ttttggctca gagtgcccaa ggtgtccgcc agccacctgg     1320

aaggcagcgg cggccagtac atcaaggcca acagcaagtt catcggcatc accgagctgc     1380

accaccatca ccaccactga taagctt                                         1407


<210>  49
<211>  375
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 49 is the nucleic acid sequence of the bacterial 
       expression plasmid pET30a-cIL-13 encoding the cIL-13 protein 
       construct of Example 3c.

<400>  49
catatgtcac ccagtccagt aacaccctca ccaactctaa aggaactaat agaagaactg       60

gtgaacatta cccaaaacca agcgagcctg tgcaacggta gcatggtgtg gagcgttaac      120

ctgaccgcgg gcatgtactg cgcggcgctg gagagcctga tcaacgtgag cgactgcagc      180

gcgattcagc gtacccaacg tatgctgaag gcgctgtgca gccagaaacc ggcggcgggt      240

caaatcagca gcgagcgtag ccgtgatacc aagatcgaag tgattcagct ggttaaaaac      300

ctgctgacct atgttcgcgg cgtttatcgc cacggcaact ttcgtcacca ccatcatcac      360

cattaatgaa agctt                                                       375


<210>  50
<211>  154
<212>  PRT
<213>  Canis

<220>
<223>  SEQ ID NO: 50 is the amino acid sequence of amino acids 110-263
 of the full length dog IL-33 protein (Uniprot O97863) canine IL-33-WT.

<400>  50

Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser 
1               5                   10                  15      


Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu Asp 
            20                  25                  30          


Leu Arg Lys Gly Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr Tyr Asp 
        35                  40                  45              


Ser Gln Ser Pro Ser His Glu Thr Gly Asp Asp Val Asp Gly Gln Thr 
    50                  55                  60                  


Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu His 
65                  70                  75                  80  


Ala Asn Asn Glu Glu His Ser Val Glu Leu Gln Lys Cys Glu Asn Gln 
                85                  90                  95      


Leu Pro Asp Gln Ala Phe Phe Leu Leu His Arg Lys Ser Ser Glu Cys 
            100                 105                 110         


Val Ser Phe Glu Cys Lys Asn Asn Pro Gly Val Phe Ile Gly Val Lys 
        115                 120                 125             


Asp Asn His Leu Ala Leu Ile Lys Val Gly Asp Gln Thr Lys Asp Ser 
    130                 135                 140                 


Tyr Ile Glu Lys Thr Ile Phe Lys Leu Ser 
145                 150                 


<210>  51
<211>  154
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 51 is the altered amino acid sequence of canine 
       IL-33-CS , which is amino acids 110-263 of the full length dog 
       IL-33 protein (Uniprot O97863), where the 3 cysteine residues are
       replaced by serine (IL-33-CS) to improve stability of the gene 
       

<400>  51

Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser 
1               5                   10                  15      


Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu Asp 
            20                  25                  30          


Leu Arg Lys Gly Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr Tyr Asp 
        35                  40                  45              


Ser Gln Ser Pro Ser His Glu Thr Gly Asp Asp Val Asp Gly Gln Thr 
    50                  55                  60                  


Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu His 
65                  70                  75                  80  


Ala Asn Asn Glu Glu His Ser Val Glu Leu Gln Lys Ser Glu Asn Gln 
                85                  90                  95      


Leu Pro Asp Gln Ala Phe Phe Leu Leu His Arg Lys Ser Ser Glu Ser 
            100                 105                 110         


Val Ser Phe Glu Ser Lys Asn Asn Pro Gly Val Phe Ile Gly Val Lys 
        115                 120                 125             


Asp Asn His Leu Ala Leu Ile Lys Val Gly Asp Gln Thr Lys Asp Ser 
    130                 135                 140                 


Tyr Ile Glu Lys Thr Ile Phe Lys Leu Ser 
145                 150                 


<210>  52
<211>  498
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 52 is the nucleic acid sequence of the plasmid 
       pET30a(+)-canIL33-WT encoding the cIL-33_WT protein construct of 
       Example 3d.

<400>  52
catatgcacc accatcatca tcacagcatc caagaataca gcgcgagcct gagcacctac       60

aacgaccaga gcatcacctt cgtgtttgaa gatggtagct acgagatcta tgtggaagac      120

ctgcgtaaag gccaggagaa ggataaagtt ctgttccgtt actatgacag ccaaagcccg      180

agccacgaaa ccggtgacga tgtggacggc cagaccctgc tggttaacct gagcccgacc      240

aaggacaaag attttctgct gcacgcgaac aacgaggaac acagcgtgga gctgcaaaag      300

tgcgaaaacc agctgccgga tcaagcgttc tttctgctgc accgtaagag cagcgagtgc      360

gttagcttcg aatgcaaaaa caacccgggt gtgtttattg gcgttaagga caaccacctg      420

gcgctgatca aagtgggcga ccaaaccaag gacagctaca tcgagaagac cattttcaaa      480

ctgagctaat gaaagctt                                                    498


<210>  53
<211>  498
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 53 is the nucleic acid sequence of the plasmid 
       pET30a(+)-canIL33-CS encoding the cIL-33_CS protein construct 
       construct of Example 3e.

<400>  53
catatgcacc accaccacca ccactcaata caagaatact cagctagtct atcaacctat       60

aacgaccaga gcattacctt tgtttttgaa gatggtagct acgagatcta tgtggaagac      120

ctgcgtaaag gccaggagaa ggataaagtt ctgttccgtt actatgacag ccaaagcccg      180

agccacgaaa ccggtgacga tgtggatggc cagaccctgc tggttaacct gagcccgacc      240

aaggacaaag attttctgct gcacgcgaac aacgaggaac acagcgtgga gctgcaaaag      300

agcgaaaacc agctgccgga tcaagcgttc tttctgctgc accgtaagag cagcgagagc      360

gttagcttcg aaagcaaaaa caacccgggt gtgtttattg gcgttaagga caaccacctg      420

gcgctgatca aggttggcga ccagaccaaa gatagctaca tcgagaagac cattttcaaa      480

ctgagctaat gaaagctt                                                    498


<210>  54
<211>  564
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 54 is the amino acid sequence of the cIL-33-CS 
       polyprotein used for the vaccine construct of Example 13d.

<400>  54

Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser 
1               5                   10                  15      


Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu Asp 
            20                  25                  30          


Leu Arg Lys Gly Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr Tyr Asp 
        35                  40                  45              


Ser Gln Ser Pro Ser His Glu Thr Gly Asp Asp Val Asp Gly Gln Thr 
    50                  55                  60                  


Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu His 
65                  70                  75                  80  


Ala Asn Asn Glu Glu His Ser Val Glu Leu Gln Lys Ser Glu Asn Gln 
                85                  90                  95      


Leu Pro Asp Gln Ala Phe Phe Leu Leu His Arg Lys Ser Ser Glu Ser 
            100                 105                 110         


Val Ser Phe Glu Ser Lys Asn Asn Pro Gly Val Phe Ile Gly Val Lys 
        115                 120                 125             


Asp Asn His Leu Ala Leu Ile Lys Val Gly Asp Gln Thr Lys Asp Ser 
    130                 135                 140                 


Tyr Ile Glu Lys Thr Ile Phe Lys Leu Ser Gly Ser Gly Gly Gln Tyr 
145                 150                 155                 160 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser 
                165                 170                 175     


Gly Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp Gln 
            180                 185                 190         


Ser Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu 
        195                 200                 205             


Asp Leu Arg Lys Gly Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr Tyr 
    210                 215                 220                 


Asp Ser Gln Ser Pro Ser His Glu Thr Gly Asp Asp Val Asp Gly Gln 
225                 230                 235                 240 


Thr Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu 
                245                 250                 255     


His Ala Asn Asn Glu Glu His Ser Val Glu Leu Gln Lys Ser Glu Asn 
            260                 265                 270         


Gln Leu Pro Asp Gln Ala Phe Phe Leu Leu His Arg Lys Ser Ser Glu 
        275                 280                 285             


Ser Val Ser Phe Glu Ser Lys Asn Asn Pro Gly Val Phe Ile Gly Val 
    290                 295                 300                 


Lys Asp Asn His Leu Ala Leu Ile Lys Val Gly Asp Gln Thr Lys Asp 
305                 310                 315                 320 


Ser Tyr Ile Glu Lys Thr Ile Phe Lys Leu Ser Ala Gly Ser Gly Phe 
                325                 330                 335     


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
            340                 345                 350         


Ser His Leu Glu Ser Gly Gly Ser Ser Ile Gln Glu Tyr Ser Ala Ser 
        355                 360                 365             


Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Val Phe Glu Asp Gly 
    370                 375                 380                 


Ser Tyr Glu Ile Tyr Val Glu Asp Leu Arg Lys Gly Gln Glu Lys Asp 
385                 390                 395                 400 


Lys Val Leu Phe Arg Tyr Tyr Asp Ser Gln Ser Pro Ser His Glu Thr 
                405                 410                 415     


Gly Asp Asp Val Asp Gly Gln Thr Leu Leu Val Asn Leu Ser Pro Thr 
            420                 425                 430         


Lys Asp Lys Asp Phe Leu Leu His Ala Asn Asn Glu Glu His Ser Val 
        435                 440                 445             


Glu Leu Gln Lys Ser Glu Asn Gln Leu Pro Asp Gln Ala Phe Phe Leu 
    450                 455                 460                 


Leu His Arg Lys Ser Ser Glu Ser Val Ser Phe Glu Ser Lys Asn Asn 
465                 470                 475                 480 


Pro Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys 
                485                 490                 495     


Val Gly Asp Gln Thr Lys Asp Ser Tyr Ile Glu Lys Thr Ile Phe Lys 
            500                 505                 510         


Leu Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu 
        515                 520                 525             


Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln 
    530                 535                 540                 


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His 
545                 550                 555                 560 


His His His His 
                


<210>  55
<211>  1710
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 55 is the nucleic acid sequence of the plasmid 
       pET30a-cIL33-(CS-)poly encoding the cIL-33-CS polyprotein 
       construct of Example 1d.

<400>  55
catatgcacc accatcatca ccactccatc caagaatact ccgcttccct gagcacctat       60

aacgaccaat ccattacctt tgtgtttgaa gatggcagtt atgaaattta cgtcgaagat      120

ctgcgtaagg gtcaggaaaa agacaaagtg ctgtttcgct attacgatag tcaatccccg      180

tcacatgaaa ccggcgatga cgttgatggt cagacgctgc tggtcaacct gagcccgacc      240

aaagataaag acttcctgct gcatgcgaac aatgaagaac actcggtgga actgcagaaa      300

agcgaaaatc agctgccgga ccaagccttt ttcctgctgc atcgtaaaag ctctgaatcg      360

gttagctttg aaagcaaaaa caatccgggc gttttcattg gtgtcaaaga taaccacctg      420

gcactgatca aagtcggcga tcagacgaaa gactcgtaca tcgaaaaaac catcttcaaa      480

ctgtctggca gtggcggtca atacattaaa gcgaactcaa aattcattgg tatcaccgaa      540

ctggcgggct ccggttcaat ccaggaatat tcggccagcc tgtctaccta caatgaccaa      600

tcgattacgt ttgttttcga agatggcagc tatgaaatct acgtcgaaga cctgcgtaaa      660

ggtcaagaaa aagataaagt tctgttccgc tattacgaca gtcagtcccc gtcacacgaa      720

acgggcgatg acgtggatgg tcaaaccctg ctggttaacc tgagcccgac gaaagataaa      780

gactttctgc tgcatgcaaa caatgaagaa cactctgttg aactgcagaa aagtgaaaat      840

cagctgccgg atcaggcgtt tttcctgctg caccgcaaaa gttccgaatc ggtgagcttt      900

gaatctaaaa ataatccggg cgtgttcatt ggtgttaaag ataaccacct ggcgctgatc      960

aaagttggtg atcagaccaa agactcttac atcgaaaaaa cgatcttcaa actgtctgcc     1020

ggcagtggtt ttaacaattt caccgtgtcc ttctggctgc gcgtgccgaa agtttctgca     1080

agtcatctgg aatcaggcgg ttcatcgatt caggaatatt ccgcttcact gtcgacctac     1140

aatgaccaat ctattacgtt tgtgttcgaa gatggcagtt atgaaatcta cgttgaagat     1200

ctgcgtaagg gccaagaaaa agataaagtc ctgttccgct attacgatag ccaatctccg     1260

agtcacgaaa ccggcgatga cgtcgacggc cagacgctgc tggtgaacct gtctccgacg     1320

aaagacaaag actttctgct gcacgccaat aatgaagaac actccgttga actgcagaaa     1380

tcagaaaacc aactgccgga tcaagccttt ttcctgttac accgcaaaag ctctgaatcc     1440

gtctcatttg aatctaaaaa taacccgggc gtcttcattg gtgtgaaaga taatcacctg     1500

gccctgatca aagttggcga ccaaacgaaa gactcctata ttgaaaaaac gatttttaaa     1560

ctgtccgcag gctcaggctt caacaatttc accgtgagtt tctggctgcg cgtcccgaaa     1620

gtgtcggcta gccatctgga aggctcaggc ggtcaataca tcaaagcgaa cagcaaattc     1680

atcggcatca cggaactgta atgaaagctt                                      1710


<210>  56
<211>  108
<212>  PRT
<213>  Canis

<220>
<223>  SEQ ID NO: 56 is the amino acid sequence of canine IL-4.

<400>  56

His Asn Phe Asn Ile Thr Ile Lys Glu Ile Ile Lys Met Leu Asn Ile 
1               5                   10                  15      


Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val Lys Asp Val 
            20                  25                  30          


Phe Thr Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Ile Tyr Thr His Asn Cys Ser Asn Arg Tyr 
    50                  55                  60                  


Leu Arg Gly Leu Tyr Arg Asn Leu Ser Ser Met Ala Asn Lys Thr Cys 
65                  70                  75                  80  


Ser Met Asn Glu Ile Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg 
                85                  90                  95      


Leu Lys Val Ile Met Gln Lys Lys Tyr Tyr Arg His 
            100                 105             


<210>  57
<211>  426
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 57 is the amino acid sequence of the cIL-4 polyprotein
       used for the vaccine construct of Example 13e.

<400>  57

His Asn Phe Asn Ile Thr Ile Lys Glu Ile Ile Lys Met Leu Asn Ile 
1               5                   10                  15      


Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val Lys Asp Val 
            20                  25                  30          


Phe Thr Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Ile Tyr Thr His Asn Cys Ser Asn Arg Tyr 
    50                  55                  60                  


Leu Arg Gly Leu Tyr Arg Asn Leu Ser Ser Met Ala Asn Lys Thr Cys 
65                  70                  75                  80  


Ser Met Asn Glu Ile Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg 
                85                  90                  95      


Leu Lys Val Ile Met Gln Lys Lys Tyr Tyr Arg His Gly Ser Gly Gly 
            100                 105                 110         


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala 
        115                 120                 125             


Gly Ser Gly His Asn Phe Asn Ile Thr Ile Lys Glu Ile Ile Lys Met 
    130                 135                 140                 


Leu Asn Ile Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val 
145                 150                 155                 160 


Lys Asp Val Phe Thr Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe 
                165                 170                 175     


Cys Arg Ala Ala Thr Val Leu Arg Gln Ile Tyr Thr His Asn Cys Ser 
            180                 185                 190         


Asn Arg Tyr Leu Arg Gly Leu Tyr Arg Asn Leu Ser Ser Met Ala Asn 
        195                 200                 205             


Lys Thr Cys Ser Met Asn Glu Ile Lys Lys Ser Thr Leu Lys Asp Phe 
    210                 215                 220                 


Leu Glu Arg Leu Lys Val Ile Met Gln Lys Lys Tyr Tyr Arg His Ala 
225                 230                 235                 240 


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
                245                 250                 255     


Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser His Asn Phe Asn 
            260                 265                 270         


Ile Thr Ile Lys Glu Ile Ile Lys Met Leu Asn Ile Leu Thr Ala Arg 
        275                 280                 285             


Asn Asp Ser Cys Met Glu Leu Thr Val Lys Asp Val Phe Thr Ala Pro 
    290                 295                 300                 


Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala Ala Thr Val Leu 
305                 310                 315                 320 


Arg Gln Ile Tyr Thr His Asn Cys Ser Asn Arg Tyr Leu Arg Gly Leu 
                325                 330                 335     


Tyr Arg Asn Leu Ser Ser Met Ala Asn Lys Thr Cys Ser Met Asn Glu 
            340                 345                 350         


Ile Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Val Ile 
        355                 360                 365             


Met Gln Lys Lys Tyr Tyr Arg His Ala Gly Ser Gly Phe Asn Asn Phe 
    370                 375                 380                 


Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu 
385                 390                 395                 400 


Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
                405                 410                 415     


Ile Thr Glu Leu His His His His His His 
            420                 425     


<210>  58
<211>  1362
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 58 is the nucleic acid sequence of the plasmid 
       pcDNA3.4-cIL-5-poly encoding the cIL-4 polyprotein construct of 
       Example 1e.

<400>  58
gaattcccgc cgccaccatg ggttggagtt gcatcatcct atttctagtg gccacagcca       60

ccggcgtgca ctcgcacaac ttcaacataa caatcaaaga gatcatcaag atgctgaata      120

ttctgaccgc cagaaacgat tcctgcatgg aactgacagt caaggacgtg tttaccgctc      180

caaagaacac ctctgacaag gagatcttct gcagagctgc taccgtgctg cggcaaatct      240

acacccacaa ctgcagcaac cggtacctgc ggggcctgta ccggaacctg tcctctatgg      300

ccaacaagac ctgcagcatg aacgagatca agaagtccac cctgaaggac tttctggagc      360

ggctgaaggt catcatgcag aagaaatatt acaggcacgg cagtggcggc cagtacatca      420

aggccaattc taagttcatc ggcatcaccg agctggccgg ctctggccac aacttcaaca      480

tcaccatcaa agagatcatc aagatgctga acatcctgac cgcacggaac gactcttgca      540

tggaactgac cgtgaaggac gtgttcactg ctcctaagaa cacctctgat aaagaaatct      600

tctgtagagc cgctaccgtg ctgagacaga tctacacaca taactgctcc aacagatacc      660

tgagaggcct gtacagaaat ctgtcctcta tggccaacaa gacctgttcc atgaacgaaa      720

tcaaaaagtc caccctaaag gatttcctgg aacggctgaa ggtgatcatg cagaaaaagt      780

actaccggca cgctggcagc ggctttaaca actttacagt gtccttctgg ctgagagtgc      840

ctaaggtgtc cgcctcccat ttggagtccg gcggatctca caacttcaac atcaccatca      900

aggagatcat caagatgctg aacatcctga ccgctcggaa cgactcctgt atggaactca      960

cagtgaagga cgtgttcacc gcccccaaga atacctccga caaggagatc ttctgcagag     1020

ccgccacagt tctgcggcag atctataccc acaattgctc caacagatac ctcagaggcc     1080

tgtaccgcaa cctgagctcc atggctaaca aaacctgctc catgaacgag atcaagaaga     1140

gcaccctgaa agacttcctg gagagactga aggtgatcat gcagaagaag tactacagac     1200

acgccggatc tggcttcaat aacttcaccg tgtctttctg gctgagagtg cctaaggtgt     1260

ctgctagcca cctggaaggt tctggaggcc agtacatcaa ggccaactcc aagttcatcg     1320

gcattaccga gctgcaccat caccaccacc actgataagc tt                        1362


<210>  59
<211>  357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 59 is the nucleic acid sequence of the bacterial 
       expression plasmid pET30a-cIL-4 encoding the cIL-4 protein 
       construct of Example 3f.

<400>  59
catatgcacc accaccacca ccacaacttc aacataacaa taaaggaaat aatcaaaatg       60

ctgaacatcc tgaccgcgcg taacgatagc tgcatggagc tgaccgtgaa ggacgttttc      120

accgcgccga agaacaccag cgataaagaa atcttttgcc gtgcggcgac cgtgctgcgt      180

cagatttaca cccacaactg cagcaaccgt tacctgcgtg gtctgtatcg taacctgagc      240

agcatggcga acaaaacctg cagcatgaac gagatcaaga aaagcaccct gaaggatttc      300

ctggagcgcc tgaaggttat tatgcagaag aagtattacc gccactaatg aaagctt         357


<210>  60
<211>  133
<212>  PRT
<213>  Felis catus

<220>
<223>  SEQ ID NO: 60 is the amino acid sequence of feline IL-31.

<400>  60

Ala Pro Ala His Arg Leu Gln Pro Ser Asp Val Arg Lys Ile Ile Leu 
1               5                   10                  15      


Glu Leu Arg Pro Met Ser Lys Gly Leu Leu Gln Asp Tyr Val Ser Lys 
            20                  25                  30          


Glu Ile Gly Leu Pro Glu Ser Asn His Ser Ser Leu Pro Cys Leu Ser 
        35                  40                  45              


Ser Asp Ser Gln Leu Pro His Ile Asn Gly Ser Ala Ile Leu Pro Tyr 
    50                  55                  60                  


Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile 
65                  70                  75                  80  


Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln Arg Glu Pro Glu Ala Lys 
                85                  90                  95      


Val Ser Met Pro Ala Asp Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala 
            100                 105                 110         


Val Leu Gln Gln Phe Ser Ala Cys Leu Glu His Val Leu Gln Ser Leu 
        115                 120                 125             


Asn Ser Gly Pro Gln 
    130             


<210>  61
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 61 is the amino acid sequence of the feline IL-31 
       polyprotein used for the vaccine construct of Example 13f.

<400>  61

Ala Pro Ala His Arg Leu Gln Pro Ser Asp Val Arg Lys Ile Ile Leu 
1               5                   10                  15      


Glu Leu Arg Pro Met Ser Lys Gly Leu Leu Gln Asp Tyr Val Ser Lys 
            20                  25                  30          


Glu Ile Gly Leu Pro Glu Ser Asn His Ser Ser Leu Pro Cys Leu Ser 
        35                  40                  45              


Ser Asp Ser Gln Leu Pro His Ile Asn Gly Ser Ala Ile Leu Pro Tyr 
    50                  55                  60                  


Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile 
65                  70                  75                  80  


Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln Arg Glu Pro Glu Ala Lys 
                85                  90                  95      


Val Ser Met Pro Ala Asp Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala 
            100                 105                 110         


Val Leu Gln Gln Phe Ser Ala Cys Leu Glu His Val Leu Gln Ser Leu 
        115                 120                 125             


Asn Ser Gly Pro Gln Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    130                 135                 140                 


Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ala Pro Ala His 
145                 150                 155                 160 


Arg Leu Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Arg Pro 
                165                 170                 175     


Met Ser Lys Gly Leu Leu Gln Asp Tyr Val Ser Lys Glu Ile Gly Leu 
            180                 185                 190         


Pro Glu Ser Asn His Ser Ser Leu Pro Cys Leu Ser Ser Asp Ser Gln 
        195                 200                 205             


Leu Pro His Ile Asn Gly Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile 
    210                 215                 220                 


Arg Pro Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile Ile Glu Gln Leu 
225                 230                 235                 240 


Asp Lys Leu Lys Phe Gln Arg Glu Pro Glu Ala Lys Val Ser Met Pro 
                245                 250                 255     


Ala Asp Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala Val Leu Gln Gln 
            260                 265                 270         


Phe Ser Ala Cys Leu Glu His Val Leu Gln Ser Leu Asn Ser Gly Pro 
        275                 280                 285             


Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
    290                 295                 300                 


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Ala Pro 
305                 310                 315                 320 


Ala His Arg Leu Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu 
                325                 330                 335     


Arg Pro Met Ser Lys Gly Leu Leu Gln Asp Tyr Val Ser Lys Glu Ile 
            340                 345                 350         


Gly Leu Pro Glu Ser Asn His Ser Ser Leu Pro Cys Leu Ser Ser Asp 
        355                 360                 365             


Ser Gln Leu Pro His Ile Asn Gly Ser Ala Ile Leu Pro Tyr Phe Arg 
    370                 375                 380                 


Ala Ile Arg Pro Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile Ile Glu 
385                 390                 395                 400 


Gln Leu Asp Lys Leu Lys Phe Gln Arg Glu Pro Glu Ala Lys Val Ser 
                405                 410                 415     


Met Pro Ala Asp Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala Val Leu 
            420                 425                 430         


Gln Gln Phe Ser Ala Cys Leu Glu His Val Leu Gln Ser Leu Asn Ser 
        435                 440                 445             


Gly Pro Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
    450                 455                 460                 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly 
465                 470                 475                 480 


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His 
                485                 490                 495     


His His His His His 
            500     


<210>  62
<211>  7597
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 62 is the nucleic acid sequence of the plasmid 
       pcDNA3.4-felIL31-poly encoding the feline IL-31 polyprotein 
       construct of Example 1g.

<400>  62
gttaggcgtt ttgcgctgct tcgcgatgta cgggccagat atacgcgttg acattgatta       60

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag      120

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc      180

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga      240

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      300

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      360

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      420

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca      480

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat      540

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg      600

cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg      660

agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc cagcctccgg      720

actctagagg atcgaaccct tgaattcccg ccgccaccat gggatggtcc tgcatcattc      780

tgttcctggt ggccaccgcc acaggcgtgc acagcgcccc cgcccacaga ctgcaaccta      840

gcgacgtcag gaaaatcatc ttggagctga gacctatgag caaaggcctg ctgcaggact      900

acgtgtccaa agagattggc ctgccagaat ctaatcactc tagcctgcct tgcctgtcta      960

gcgacagcca gctgccccac atcaacggct ccgccatcct gccctacttt agagccatca     1020

gacctctgtc cgacaaaaac accatcgaca agatcatcga gcagctggac aagctgaagt     1080

tccagcggga acccgaagcc aaggtttcca tgcctgctga taatttcgag agaaagaact     1140

tcatcctggc tgtgctgcag cagttcagcg cttgcctgga gcacgtgctg cagagcctga     1200

atagcggacc tcagggcagc ggcggccagt acatcaaagc caattctaaa ttcatcggca     1260

tcaccgagct ggccggcagc ggcgcccctg ctcacagact gcagcctagc gatgtgcgga     1320

agatcatcct ggagctgaga cctatgagca agggcctgct gcaggactac gtgtccaagg     1380

aaatcggcct gcccgagagc aaccacagta gcctgccatg tctgagcagc gacagccagc     1440

tgccacatat caacggcagc gccatcctgc cttacttcag agccatccgg cctctgagcg     1500

acaagaacac catcgacaag atcatcgagc agctggataa gctgaaattc cagagagagc     1560

ctgaggccaa ggtcagcatg cctgccgaca actttgagcg gaagaatttt atcctggccg     1620

tgctgcagca gttcagcgcc tgcctggaac acgtgctgca atctctgaac agcggccccc     1680

aggccggatc tggcttcaac aacttcacag tgtctttttg gctgcgggtg cccaaggtgt     1740

ccgccagcca cctggaaagc ggcggatctg ctccagctca cagactccag ccttctgatg     1800

tgcggaagat cattctggaa ctcaggccca tgagcaaggg cctgctgcag gattacgtga     1860

gcaaggaaat cggactgcct gagagcaacc acagcagcct gccttgtctg tccagcgata     1920

gccagctgcc acacatcaac ggctctgcca ttctgcctta tttccgggcc attagacccc     1980

tgagcgacaa gaacacaatc gataagatca tcgaacagct ggacaagctg aagttccaaa     2040

gagagcccga ggccaaggtg tccatgcccg ccgacaactt cgagcgcaag aacttcatcc     2100

tggctgtgct ccagcaattt agcgcctgcc tggaacacgt gctgcagagc ctgaacagcg     2160

gacctcaagc cggctctggt tttaacaact tcaccgtgtc cttctggctg agagtgccta     2220

aggtctctgc atctcatctg gaaggcagcg gcggccagta catcaaggcc aacagcaagt     2280

tcatcggcat caccgagctg caccaccacc accaccactg ataagcttaa gggttcgatc     2340

cctaccggtt agtaatgagt ttgatatctc gacaatcaac ctctggatta caaaatttgt     2400

gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct     2460

ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat     2520

aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg     2580

gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag     2640

ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc     2700

tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg     2760

tcggggaagc tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg gattctgcgc     2820

gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc     2880

ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc     2940

tccctttggg ccgcctcccc gcctggaacg ggggaggcta actgaaacac ggaaggagac     3000

aataccggaa ggaacccgcg ctatgacggc aataaaaaga cagaataaaa cgcacgggtg     3060

ttgggtcgtt tgttcataaa cgcggggttc ggtcccaggg ctggcactct gtcgataccc     3120

caccgagacc ccattggggc caatacgccc gcgtttcttc cttttcccca ccccaccccc     3180

caagttcggg tgaaggccca gggctcgcag ccaacgtcgg ggcggcaggc cctgccatag     3240

cagatctgcg cagctggggc tctagggggt atccccacgc gccctgtagc ggcgcattaa     3300

gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc     3360

ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag     3420

ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca     3480

aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc     3540

gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa     3600

cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct     3660

attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattaattc tgtggaatgt     3720

gtgtcagtta gggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat     3780

gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag caggcagaag     3840

tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa ctccgcccat     3900

cccgccccta actccgccca gttccgccca ttctccgccc catggctgac taattttttt     3960

tatttatgca gaggccgagg ccgcctctgc ctctgagcta ttccagaagt agtgaggagg     4020

cttttttgga ggcctaggct tttgcaaaaa gctcccggga gcttgtatat ccattttcgg     4080

atctgatcaa gagacaggat gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc     4140

aggttctccg gccgcttggg tggagaggct attcggctat gactgggcac aacagacaat     4200

cggctgctct gatgccgccg tgttccggct gtcagcgcag gggcgcccgg ttctttttgt     4260

caagaccgac ctgtccggtg ccctgaatga actgcaggac gaggcagcgc ggctatcgtg     4320

gctggccacg acgggcgttc cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag     4380

ggactggctg ctattgggcg aagtgccggg gcaggatctc ctgtcatctc accttgctcc     4440

tgccgagaaa gtatccatca tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc     4500

tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga     4560

agccggtctt gtcgatcagg atgatctgga cgaagagcat caggggctcg cgccagccga     4620

actgttcgcc aggctcaagg cgcgcatgcc cgacggcgag gatctcgtcg tgacccatgg     4680

cgatgcctgc ttgccgaata tcatggtgga aaatggccgc ttttctggat tcatcgactg     4740

tggccggctg ggtgtggcgg accgctatca ggacatagcg ttggctaccc gtgatattgc     4800

tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg ctttacggta tcgccgctcc     4860

cgattcgcag cgcatcgcct tctatcgcct tcttgacgag ttcttctgag cgggactctg     4920

gggttcgcga aatgaccgac caagcgacgc ccaacctgcc atcacgagat ttcgattcca     4980

ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga     5040

tcctccagcg cggggatctc atgctggagt tcttcgccca ccccaacttg tttattgcag     5100

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     5160

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctgtatac     5220

cgtcgacctc tagctagagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt     5280

gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg     5340

gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt     5400

cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt     5460

tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc     5520

tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg     5580

ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     5640

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     5700

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     5760

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     5820

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     5880

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     5940

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     6000

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     6060

tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc     6120

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     6180

ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat     6240

ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac     6300

gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt     6360

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc     6420

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg     6480

cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg     6540

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     6600

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta     6660

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg     6720

ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct     6780

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     6840

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg     6900

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga     6960

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt     7020

gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca     7080

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt     7140

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt     7200

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga     7260

aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat cagggttatt     7320

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     7380

gcacatttcc ccgaaaagtg ccacctgacg tcgacggatc gggagatctc ccgatcccct     7440

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt atctgctccc     7500

tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta caacaaggca     7560

aggcttgacc gacaattgca tgaagaatct gcttagg                              7597


<210>  63
<211>  6511
<212>  DNA
<213>  Felis catus

<220>
<223>  SEQ ID NO: 63 is the nucleic acid sequence of the plasmid 
pcDNA3.4-fel-IL31 encoding the feline IL-31 protein construct of Example 3g.

<400>  63
gttaggcgtt ttgcgctgct tcgcgatgta cgggccagat atacgcgttg acattgatta       60

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag      120

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc      180

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga      240

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      300

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      360

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      420

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca      480

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat      540

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg      600

cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg      660

agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc cagcctccgg      720

actctagagg atcgaaccct tgaattcccg ccgccaccat gggctggagc tgcatcatcc      780

tgttcctggt ggccaccgcc acaggcgtgc acagcgcccc tgcccacaga ctgcagccta      840

gcgacgtgcg caagatcatt ctggagctca gacctatgag caaaggactg ctgcaggact      900

acgtgtccaa ggaaatcggc ctgcctgaga gcaaccactc ttctctgcct tgtctgagca      960

gcgacagcca gctgccccac atcaacggct ccgctatcct tccctacttt agagccatcc     1020

ggccactgtc tgataagaac accatcgaca aaatcatcga gcagctggat aagctgaagt     1080

tccagcggga acctgaggcc aaggtcagca tgccagccga caacttcgag agaaagaatt     1140

tcatcctggc cgtgctgcaa cagttcagcg cttgcctgga acacgtgctg cagagcctga     1200

actccggccc ccagcaccac caccaccatc actgataagc ttaagggttc gatccctacc     1260

ggttagtaat gagtttgata tctcgacaat caacctctgg attacaaaat ttgtgaaaga     1320

ttgactggta ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg     1380

cctttgtatc atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc     1440

tggttgctgt ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc     1500

actgtgtttg ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt     1560

tccgggactt tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt     1620

gcccgctgct ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg     1680

aagctgacgt cctttccatg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg     1740

tccttctgct acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg     1800

ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt     1860

tgggccgcct ccccgcctgg aacgggggag gctaactgaa acacggaagg agacaatacc     1920

ggaaggaacc cgcgctatga cggcaataaa aagacagaat aaaacgcacg ggtgttgggt     1980

cgtttgttca taaacgcggg gttcggtccc agggctggca ctctgtcgat accccaccga     2040

gaccccattg gggccaatac gcccgcgttt cttccttttc cccaccccac cccccaagtt     2100

cgggtgaagg cccagggctc gcagccaacg tcggggcggc aggccctgcc atagcagatc     2160

tgcgcagctg gggctctagg gggtatcccc acgcgccctg tagcggcgca ttaagcgcgg     2220

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc     2280

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     2340

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     2400

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     2460

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     2520

accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt     2580

taaaaaatga gctgatttaa caaaaattta acgcgaatta attctgtgga atgtgtgtca     2640

gttagggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct     2700

caattagtca gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca     2760

aagcatgcat ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc     2820

cctaactccg cccagttccg cccattctcc gccccatggc tgactaattt tttttattta     2880

tgcagaggcc gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt     2940

tggaggccta ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga     3000

tcaagagaca ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc     3060

tccggccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg     3120

ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac     3180

cgacctgtcc ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc     3240

cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg     3300

gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga     3360

gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg     3420

cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg     3480

tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt     3540

cgccaggctc aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc     3600

ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg     3660

gctgggtgtg gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga     3720

gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc     3780

gcagcgcatc gccttctatc gccttcttga cgagttcttc tgagcgggac tctggggttc     3840

gcgaaatgac cgaccaagcg acgcccaacc tgccatcacg agatttcgat tccaccgccg     3900

ccttctatga aaggttgggc ttcggaatcg ttttccggga cgccggctgg atgatcctcc     3960

agcgcgggga tctcatgctg gagttcttcg cccaccccaa cttgtttatt gcagcttata     4020

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     4080

attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgt ataccgtcga     4140

cctctagcta gagcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc     4200

cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4260

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4320

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4380

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4440

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4500

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4560

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4620

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4680

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     4740

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     4800

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     4860

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     4920

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     4980

agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     5040

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5100

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5160

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5220

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5280

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5340

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     5400

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     5460

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     5520

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     5580

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     5640

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     5700

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     5760

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     5820

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     5880

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     5940

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6000

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6060

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6120

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6180

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6240

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6300

ttccccgaaa agtgccacct gacgtcgacg gatcgggaga tctcccgatc ccctatggtg     6360

cactctcagt acaatctgct ctgatgccgc atagttaagc cagtatctgc tccctgcttg     6420

tgtgttggag gtcgctgagt agtgcgcgag caaaatttaa gctacaacaa ggcaaggctt     6480

gaccgacaat tgcatgaaga atctgcttag g                                    6511


<210>  64
<211>  157
<212>  PRT
<213>  Bos taurus 

<220>
<223>  SEQ ID NO: 64 is the amino acid sequence of bovine TNF-alpha.

<400>  64

Leu Arg Ser Ser Ser Gln Ala Ser Ser Asn Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asp Ile Asn Ser Pro Gly Gln Leu Arg Trp Trp Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ala Leu Met Ala Asn Gly Val Lys Leu Glu Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ala Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Arg Gly Gln Gly Cys Pro Ser Thr Pro Leu Phe Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Ile Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys His Arg Glu Thr Pro Glu Trp Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Gln Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Leu Pro Asp Tyr Leu Asp Tyr 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


<210>  65
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 65 is the amino acid sequence of the bovine TNF-alpha 
       polyprotein used for the immunization of Example 6f.

<400>  65

Met His His His His His His Leu Arg Ser Ser Ser Gln Ala Ser Ser 
1               5                   10                  15      


Asn Lys Pro Val Ala His Val Val Ala Asp Ile Asn Ser Pro Gly Gln 
            20                  25                  30          


Leu Arg Trp Trp Asp Ser Tyr Ala Asn Ala Leu Met Ala Asn Gly Val 
        35                  40                  45              


Lys Leu Glu Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu 
    50                  55                  60                  


Ile Tyr Ser Gln Val Leu Phe Arg Gly Gln Gly Cys Pro Ser Thr Pro 
65                  70                  75                  80  


Leu Phe Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr 
                85                  90                  95      


Lys Val Asn Ile Leu Ser Ala Ile Lys Ser Pro Cys His Arg Glu Thr 
            100                 105                 110         


Pro Glu Trp Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Gln Gly 
        115                 120                 125             


Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn 
    130                 135                 140                 


Leu Pro Asp Tyr Leu Asp Tyr Ala Glu Ser Gly Gln Val Tyr Phe Gly 
145                 150                 155                 160 


Ile Ile Ala Leu Gly Gly Ser Gly Gly Ser Phe Asn Asn Phe Thr Val 
                165                 170                 175     


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
            180                 185                 190         


Ser Gly Gly Ser Gly Leu Arg Ser Ser Ser Gln Ala Ser Ser Asn Lys 
        195                 200                 205             


Pro Val Ala His Val Val Ala Asp Ile Asn Ser Pro Gly Gln Leu Arg 
    210                 215                 220                 


Trp Trp Asp Ser Tyr Ala Asn Ala Leu Met Ala Asn Gly Val Lys Leu 
225                 230                 235                 240 


Glu Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu Ile Tyr 
                245                 250                 255     


Ser Gln Val Leu Phe Arg Gly Gln Gly Cys Pro Ser Thr Pro Leu Phe 
            260                 265                 270         


Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val 
        275                 280                 285             


Asn Ile Leu Ser Ala Ile Lys Ser Pro Cys His Arg Glu Thr Pro Glu 
    290                 295                 300                 


Trp Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Gln Gly Gly Val 
305                 310                 315                 320 


Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Leu Pro 
                325                 330                 335     


Asp Tyr Leu Asp Tyr Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile 
            340                 345                 350         


Ala Leu Gly Gly Ser Gly Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
        355                 360                 365             


Phe Ile Gly Ile Thr Glu Leu Gly Gly Gly Ser Gly Gly Leu Arg Ser 
    370                 375                 380                 


Ser Ser Gln Ala Ser Ser Asn Lys Pro Val Ala His Val Val Ala Asp 
385                 390                 395                 400 


Ile Asn Ser Pro Gly Gln Leu Arg Trp Trp Asp Ser Tyr Ala Asn Ala 
                405                 410                 415     


Leu Met Ala Asn Gly Val Lys Leu Glu Asp Asn Gln Leu Val Val Pro 
            420                 425                 430         


Ala Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Arg Gly Gln 
        435                 440                 445             


Gly Cys Pro Ser Thr Pro Leu Phe Leu Thr His Thr Ile Ser Arg Ile 
    450                 455                 460                 


Ala Val Ser Tyr Gln Thr Lys Val Asn Ile Leu Ser Ala Ile Lys Ser 
465                 470                 475                 480 


Pro Cys His Arg Glu Thr Pro Glu Trp Ala Glu Ala Lys Pro Trp Tyr 
                485                 490                 495     


Glu Pro Ile Tyr Gln Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
            500                 505                 510         


Leu Ser Ala Glu Ile Asn Leu Pro Asp Tyr Leu Asp Tyr Ala Glu Ser 
        515                 520                 525             


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Ser Gly Gly Ser 
    530                 535                 540                 


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
545                 550                 555                 560 


Ala Ser His Leu Glu Gly Gly Ser Gly Gly Gly Gln Tyr Ile Lys Ala 
                565                 570                 575     


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
            580                 585     


<210>  66
<211>  7017
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 66 is the nucleic acid sequence of the bacterial 
       expression plasmid pET30a-bov-TNF-alpha-poly encoding the bovine 
       TNF-alpha polyprotein construct of Example 1h.

<400>  66
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagctttc      180

attacagctc ggtgatgccg ataaacttgc tattcgcctt gatgtattgg ccgccgccgc      240

taccaccctc caggtggctt gcgctaacct tcggcacacg taaccaaaag ctaacggtga      300

aattattgaa gctgccaccg ctgccaccca gagctataat accaaaataa acttggccgc      360

tttccgcgta gtccaggtaa tccggcaggt taatttccgc agataaacga tcacccttct      420

ccagctggaa aacgccaccc tgataaatcg gctcgtacca cggtttcgct tcagcccatt      480

ccggggtttc gcgatgacaa ggagatttga tcgcgctcag gatattcact ttagtctggt      540

agctcaccgc aatgcggcta atggtatgcg tcagaaacag cggggtacta ggacatccct      600

ggccgcgaaa cagaacttgg ctgtaaatca gatacaggcc gtctgccggc acaaccagct      660

ggttatcctc cagtttcaca ccgttcgcca ttaaagcatt cgcgtagctg tcccaccaac      720

gcagttggcc cgggctgtta atgtccgcaa caacatgcgc caccggtttg ttagagctcg      780

cctgagaact agagcgcagg ccaccgctgc caccgcccag ttcggtaata ccgataaatt      840

tgctgttcgc cttgatatat tgaccgccac cgctgccacc cagagcgata ataccaaaat      900

aaacctgacc gctctccgcg tagtccagat aatccggcag gttgatttcc gcgctcagac      960

ggtcaccttt ttccagttga aacacgccac cctggtaaat cggctcatac cacggtttcg     1020

cttccgccca ctccggggtt tcgcgatggc acgggctctt gatcgcgctc agaatattca     1080

ctttggtctg gtagctcacc gcgatgcggc taatggtatg agtcagaaac agcggggtag     1140

aaggacagcc ctggccgcga aacagcactt ggctgtaaat caggtacagg ccatcagccg     1200

gcacaaccag ctgattatcc tccagtttca cgccattcgc catcagcgca ttcgcgtagc     1260

tatcccacca acgcagctgg cccgggctgt tgatgtccgc aaccacgtgc gcaaccggtt     1320

tgttgctgct cgcctggcta gaagagcgca ggccgctgcc accgctacct tccagatggc     1380

tcgcgctaac cttcggcaca cgcagccaaa agctaacggt aaagttgttg aagctgccac     1440

cgctgccacc cagcgcaatg atgccgaagt acacctgacc gctctccgca taatccaggt     1500

agtccggcag gttaatctcc gcgctcagac gatcaccttt ttccagttgg aacacgccac     1560

cctgatagat cggttcgtac cacggcttcg cctccgccca ttccggggtt tcacggtggc     1620

acgggctttt aatcgcgctc aggatgttaa ccttggtttg atagctcacc gcaatacggc     1680

tgatggtgtg ggtcagaaac agcggggtgc tcgggcaacc ttgaccacga aacagaacct     1740

ggctatagat caggtacagg ccatccgccg gcacaaccag ctggttgtct tccagcttca     1800

caccgttcgc catcagcgcg ttcgcgtagc tgtcccacca acgcagttga cccgggctat     1860

tgatgtccgc cactacgtga gctacgggtt tatttgaact agcttgtgaa cttgacctta     1920

ggtggtgatg gtgatgatgc atatgtatat ctccttctta aagttaaaca aaattatttc     1980

tagaggggaa ttgttatccg ctcacaattc ccctatagtg agtcgtatta atttcgcggg     2040

atcgagatcg atctcgatcc tctacgccgg acgcatcgtg gccggcatca ccggcgccac     2100

aggtgcggtt gctggcgcct atatcgccga catcaccgat ggggaagatc gggctcgcca     2160

cttcgggctc atgagcgctt gtttcggcgt gggtatggtg gcaggccccg tggccggggg     2220

actgttgggc gccatctcct tgcatgcacc attccttgcg gcggcggtgc tcaacggcct     2280

caacctacta ctgggctgct tcctaatgca ggagtcgcat aagggagagc gtcgagatcc     2340

cggacaccat cgaatggcgc aaaacctttc gcggtatggc atgatagcgc ccggaagaga     2400

gtcaattcag ggtggtgaat gtgaaaccag taacgttata cgatgtcgca gagtatgccg     2460

gtgtctctta tcagaccgtt tcccgcgtgg tgaaccaggc cagccacgtt tctgcgaaaa     2520

cgcgggaaaa agtggaagcg gcgatggcgg agctgaatta cattcccaac cgcgtggcac     2580

aacaactggc gggcaaacag tcgttgctga ttggcgttgc cacctccagt ctggccctgc     2640

acgcgccgtc gcaaattgtc gcggcgatta aatctcgcgc cgatcaactg ggtgccagcg     2700

tggtggtgtc gatggtagaa cgaagcggcg tcgaagcctg taaagcggcg gtgcacaatc     2760

ttctcgcgca acgcgtcagt gggctgatca ttaactatcc gctggatgac caggatgcca     2820

ttgctgtgga agctgcctgc actaatgttc cggcgttatt tcttgatgtc tctgaccaga     2880

cacccatcaa cagtattatt ttctcccatg aagacggtac gcgactgggc gtggagcatc     2940

tggtcgcatt gggtcaccag caaatcgcgc tgttagcggg cccattaagt tctgtctcgg     3000

cgcgtctgcg tctggctggc tggcataaat atctcactcg caatcaaatt cagccgatag     3060

cggaacggga aggcgactgg agtgccatgt ccggttttca acaaaccatg caaatgctga     3120

atgagggcat cgttcccact gcgatgctgg ttgccaacga tcagatggcg ctgggcgcaa     3180

tgcgcgccat taccgagtcc gggctgcgcg ttggtgcgga catctcggta gtgggatacg     3240

acgataccga agacagctca tgttatatcc cgccgttaac caccatcaaa caggattttc     3300

gcctgctggg gcaaaccagc gtggaccgct tgctgcaact ctctcagggc caggcggtga     3360

agggcaatca gctgttgccc gtctcactgg tgaaaagaaa aaccaccctg gcgcccaata     3420

cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt     3480

cccgactgga aagcgggcag tgagcgcaac gcaattaatg taagttagct cactcattag     3540

gcaccgggat ctcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3600

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3660

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3720

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3780

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     3840

gccccacggg tgcgcatgat cgtgctcctg tcgttgagga cccggctagg ctggcggggt     3900

tgccttactg gttagcagaa tgaatcaccg atacgcgagc gaacgtgaag cgactgctgc     3960

tgcaaaacgt ctgcgacctg agcaacaaca tgaatggtct tcggtttccg tgtttcgtaa     4020

agtctggaaa cgcggaagtc agcgccctgc accattatgt tccggatctg catcgcagga     4080

tgctgctggc taccctgtgg aacacctaca tctgtattaa cgaagcgctg gcattgaccc     4140

tgagtgattt ttctctggtc ccgccgcatc cataccgcca gttgtttacc ctcacaacgt     4200

tccagtaacc gggcatgttc atcatcagta acccgtatcg tgagcatcct ctctcgtttc     4260

atcggtatca ttacccccat gaacagaaat cccccttaca cggaggcatc agtgaccaaa     4320

caggaaaaaa ccgcccttaa catggcccgc tttatcagaa gccagacatt aacgcttctg     4380

gagaaactca acgagctgga cgcggatgaa caggcagaca tctgtgaatc gcttcacgac     4440

cacgctgatg agctttaccg cagctgcctc gcgcgtttcg gtgatgacgg tgaaaacctc     4500

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga     4560

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggcgcagc catgacccag     4620

tcacgtagcg atagcggagt gtatactggc ttaactatgc ggcatcagag cagattgtac     4680

tgagagtgca ccatatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg     4740

catcaggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg     4800

gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa     4860

cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc     4920

gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc     4980

aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag     5040

ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct     5100

cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta     5160

ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc     5220

cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc     5280

agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt     5340

gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct gcgctctgct     5400

gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc     5460

tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     5520

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     5580

agggattttg gtcatgaaca ataaaactgt ctgcttacat aaacagtaat acaaggggtg     5640

ttatgagcca tattcaacgg gaaacgtctt gctctaggcc gcgattaaat tccaacatgg     5700

atgctgattt atatgggtat aaatgggctc gcgataatgt cgggcaatca ggtgcgacaa     5760

tctatcgatt gtatgggaag cccgatgcgc cagagttgtt tctgaaacat ggcaaaggta     5820

gcgttgccaa tgatgttaca gatgagatgg tcagactaaa ctggctgacg gaatttatgc     5880

ctcttccgac catcaagcat tttatccgta ctcctgatga tgcatggtta ctcaccactg     5940

cgatccccgg gaaaacagca ttccaggtat tagaagaata tcctgattca ggtgaaaata     6000

ttgttgatgc gctggcagtg ttcctgcgcc ggttgcattc gattcctgtt tgtaattgtc     6060

cttttaacag cgatcgcgta tttcgtctcg ctcaggcgca atcacgaatg aataacggtt     6120

tggttgatgc gagtgatttt gatgacgagc gtaatggctg gcctgttgaa caagtctgga     6180

aagaaatgca taaacttttg ccattctcac cggattcagt cgtcactcat ggtgatttct     6240

cacttgataa ccttattttt gacgagggga aattaatagg ttgtattgat gttggacgag     6300

tcggaatcgc agaccgatac caggatcttg ccatcctatg gaactgcctc ggtgagtttt     6360

ctccttcatt acagaaacgg ctttttcaaa aatatggtat tgataatcct gatatgaata     6420

aattgcagtt tcatttgatg ctcgatgagt ttttctaaga attaattcat gagcggatac     6480

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     6540

gtgccacctg aaattgtaaa cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa     6600

atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa atcaaaagaa     6660

tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact attaaagaac     6720

gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa     6780

ccatcaccct aatcaagttt tttggggtcg aggtgccgta aagcactaaa tcggaaccct     6840

aaagggagcc cccgatttag agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa     6900

gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc     6960

gtaaccacca cacccgccgc gcttaatgcg ccgctacagg gcgcgtccca ttcgcca        7017


<210>  67
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 67 is the amino acid sequence of the artificial ER 
       import signal used for mammalian expression in the given 
       examples.

<400>  67

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  68
<211>  138
<212>  PRT
<213>  Sus scrofa

<220>
<223>  This is the amino acid sequence of Pig IL-31 protein.

<400>  68

Met Ala Pro Thr Ser Val Pro Ser Pro Glu Glu Gln Lys Gly Ile Ile 
1               5                   10                  15      


Lys Glu Leu Gln Ala Ser Val Lys Lys Val Leu Lys Asp Tyr Glu Glu 
            20                  25                  30          


Lys Glu Lys Gly Val Gln Glu Gln Glu Arg Phe Gln Ile Pro Cys Leu 
        35                  40                  45              


Thr Phe Asn Pro Gln Ser Pro His Asn Ile Glu Ser Ser Ala Ile Leu 
    50                  55                  60                  


Pro Tyr Leu Arg Ala Ile Lys Arg Ser Phe Asp Asn Asp Asp Asp Ile 
65                  70                  75                  80  


Ile Asp Ile Ile Asn His Leu His Lys Leu Lys Phe Gln Gln Gly Pro 
                85                  90                  95      


Glu Thr Thr Val Pro Val Pro Thr Asn Ser Phe Glu Gly Lys Ser Phe 
            100                 105                 110         


Thr Leu Ser Ile Leu Lys Ala Phe Ser Lys Cys Leu Thr Ser Asp Phe 
        115                 120                 125             


Asn Ser His Asp Pro Arg Arg Gly Gln Ser 
    130                 135             


<210>  69
<211>  141
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-31 protein.


<400>  69

Ser His Thr Leu Pro Val Arg Leu Leu Arg Pro Ser Asp Asp Val Gln 
1               5                   10                  15      


Lys Ile Val Glu Glu Leu Gln Ser Leu Ser Lys Met Leu Leu Lys Asp 
            20                  25                  30          


Val Glu Glu Glu Lys Gly Val Leu Val Ser Gln Asn Tyr Thr Leu Pro 
        35                  40                  45              


Cys Leu Ser Pro Asp Ala Gln Pro Pro Asn Asn Ile His Ser Pro Ala 
    50                  55                  60                  


Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln Leu Asp Asn Lys Ser Val 
65                  70                  75                  80  


Ile Asp Glu Ile Ile Glu His Leu Asp Lys Leu Ile Phe Gln Asp Ala 
                85                  90                  95      


Pro Glu Thr Asn Ile Ser Val Pro Thr Asp Thr His Glu Cys Lys Arg 
            100                 105                 110         


Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser Glu Cys Met Asp Leu Ala 
        115                 120                 125             


Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln Ala Thr Thr 
    130                 135                 140     


<210>  70
<211>  109
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-4 protein.


<400>  70

Gln Asn Phe Asn Asn Thr Leu Lys Glu Ile Ile Lys Thr Leu Asn Ile 
1               5                   10                  15      


Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val Met Asp Val 
            20                  25                  30          


Leu Ala Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala 
        35                  40                  45              


Thr Thr Val Leu Arg Gln Ile Tyr Thr His His Asn Cys Ser Thr Lys 
    50                  55                  60                  


Phe Leu Lys Gly Leu Asp Arg Asn Leu Ser Ser Met Ala Asn Arg Thr 
65                  70                  75                  80  


Cys Ser Val Asn Glu Val Lys Lys Cys Thr Leu Lys Asp Phe Leu Glu 
                85                  90                  95      


Arg Leu Lys Ala Ile Met Gln Lys Lys Tyr Ser Lys His 
            100                 105                 


<210>  71
<211>  109
<212>  PRT
<213>  Sus scrofa

<220>
<223>  This is the amino acid sequence of Pig IL-4 protein.


<400>  71

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ile 
1               5                   10                  15      


Leu Thr Ala Arg Lys Asn Ser Cys Met Glu Leu Pro Val Thr Asp Val 
            20                  25                  30          


Phe Ala Ala Pro Glu Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ser Thr Val Leu Arg His Ile Tyr Arg His His Thr Cys Met Lys Ser 
    50                  55                  60                  


Leu Leu Ser Gly Leu Asp Arg Asn Leu Ser Ser Met Ala Asn Met Thr 
65                  70                  75                  80  


Cys Ser Val His Glu Ala Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu 
                85                  90                  95      


Arg Leu Lys Thr Ile Met Lys Glu Lys Tyr Ser Lys Cys 
            100                 105                 


<210>  72
<211>  116
<212>  PRT
<213>  Gallus gallus

<220>
<223>  This is the amino acid sequence of Chicken IL-4 protein.


<400>  72

Val Pro Met Leu Cys Leu Gln Leu Ser Val Pro Leu Met Glu Ser Ile 
1               5                   10                  15      


Arg Ile Val Asn Asp Ile Gln Gly Glu Val Ser Cys Val Lys Met Asn 
            20                  25                  30          


Val Thr Asp Ile Phe Ala Asp Asn Lys Thr Asn Asn Lys Thr Glu Leu 
        35                  40                  45              


Leu Cys Lys Ala Ser Thr Ile Val Trp Glu Ser Gln His Cys His Lys 
    50                  55                  60                  


Asn Leu Gln Gly Leu Phe Leu Asn Met Arg Gln Leu Leu Asn Ala Ser 
65                  70                  75                  80  


Ser Thr Ser Leu Lys Ala Pro Cys Pro Thr Ala Ala Gly Asn Thr Thr 
                85                  90                  95      


Ser Met Glu Lys Phe Leu Ala Asp Leu Arg Thr Phe Phe His Gln Leu 
            100                 105                 110         


Ala Lys Asn Lys 
        115     


<210>  73
<211>  111
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine IL-4 protein.


<400>  73

His Lys Cys Asp Ile Thr Leu Ala Glu Ile Ile Lys Thr Leu Asn Ile 
1               5                   10                  15      


Leu Thr Thr Arg Lys Asn Ser Cys Met Glu Leu Pro Val Ala Asp Val 
            20                  25                  30          


Phe Ala Ala Pro Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Val 
        35                  40                  45              


Gly Ile Glu Leu Arg Arg Ile Tyr Arg Ser His Thr Cys Leu Asn Lys 
    50                  55                  60                  


Phe Leu Gly Gly Leu Asp Arg Asn Leu Asn Ser Leu Ala Ser Lys Thr 
65                  70                  75                  80  


Cys Ser Val Asn Glu Ala Lys Thr Ser Thr Ser Thr Leu Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Leu Lys Thr Ile Met Lys Glu Lys Tyr Ser Lys Cys 
            100                 105                 110     


<210>  74
<211>  129
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-4 Isoform 1 protein.


<400>  74

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  75
<211>  113
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-4 Isoform 2 protein.


<400>  75

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
            20                  25                  30          


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
        35                  40                  45              


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
    50                  55                  60                  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
65                  70                  75                  80  


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
                85                  90                  95      


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
            100                 105                 110         


Ser 
    


<210>  76
<211>  115
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-5 protein.


<400>  76

Ile Ala Val Gln Ser Pro Met Asn Arg Leu Val Ala Glu Thr Leu Ala 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Leu Leu Ile Gly Asp Gly Asn Leu Met 
            20                  25                  30          


Ile Pro Thr Pro Glu His Asn Asn His Gln Leu Cys Ile Glu Glu Val 
        35                  40                  45              


Phe Gln Gly Ile Asp Thr Leu Lys Asn Arg Thr Val Pro Gly Asp Ala 
    50                  55                  60                  


Val Glu Lys Leu Phe Arg Asn Leu Ser Leu Ile Lys Glu His Ile Asp 
65                  70                  75                  80  


Arg Gln Lys Lys Lys Cys Gly Gly Glu Arg Trp Arg Val Lys Lys Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Val Phe Leu Gly Val Ile Asn Thr Glu Trp Thr 
            100                 105                 110         


Met Glu Ser 
        115 


<210>  77
<211>  113
<212>  PRT
<213>  Sus scrofa

<220>
<223>  This is the amino acid sequence of Pig IL-5 protein.


<400>  77

Val Glu Asn Thr Met Asn Arg Leu Val Ala Glu Thr Leu Thr Leu Leu 
1               5                   10                  15      


Ser Ile His Arg Thr Leu Leu Ile Gly Asp Gly Asn Leu Met Ile Ser 
            20                  25                  30          


Thr Pro Val His Thr Asn His Gln Leu Cys Ile Glu Glu Val Phe Gln 
        35                  40                  45              


Gly Ile Asp Thr Leu Lys Asn Gln Thr Ala Arg Gly Asp Ala Val Glu 
    50                  55                  60                  


Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Glu Tyr Ile Asp Arg Gln 
65                  70                  75                  80  


Lys Lys Asn Cys Gly Gly Glu Arg Trp Arg Val Thr Gln Phe Leu Asp 
                85                  90                  95      


Tyr Leu Gln Val Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Met Glu 
            100                 105                 110         


Ser 
    


<210>  78
<211>  110
<212>  PRT
<213>  Gallus gallus

<220>
<223>  This is the amino acid sequence of Chicken IL-5, 126 aa protein.


<400>  78

Thr Pro Leu Arg Ser Asn Leu Ala Glu Leu Gln Thr Trp Leu Gln Gln 
1               5                   10                  15      


Ile Tyr Gln Ser Val Asp Met Leu Asn Leu Arg Ile Glu Thr Pro Val 
            20                  25                  30          


Ser Ala Asp Asp Glu Asn Cys Ile Lys Thr Leu Phe Glu Gly Thr Ala 
        35                  40                  45              


Leu Leu Lys Asn Asn Pro Glu Met Arg Arg Phe Gly Thr Phe Phe Gln 
    50                  55                  60                  


Ser Phe Asp Lys Leu Arg Pro Ser Leu Thr Ala Gln Leu Thr Gly Glu 
65                  70                  75                  80  


Gly Glu Cys Asp Thr Glu Arg Lys Asn Val Lys Lys Phe Ile Glu Lys 
                85                  90                  95      


Leu Arg Thr Phe Ile Arg Lys Leu Ser Arg Asp Ala Arg Val 
            100                 105                 110 


<210>  79
<211>  120
<212>  PRT
<213>  Gallus gallus

<220>
<223>  This is the amino acid sequence of Chicken IL-5, 136 aa protein.


<400>  79

Thr Pro Leu Arg Ser Asn Leu Ala Glu Leu Gln Thr Trp Leu Gln Gln 
1               5                   10                  15      


Ile Tyr Gln Ser Val Asp Met Leu Val Ser Ser Ile Phe Tyr Phe Cys 
            20                  25                  30          


Ser Met Asn Leu Arg Ile Glu Thr Pro Val Ser Ala Asp Asp Glu Asn 
        35                  40                  45              


Cys Ile Lys Thr Leu Phe Glu Gly Thr Ala Leu Leu Lys Asn Asn Pro 
    50                  55                  60                  


Glu Met Arg Arg Phe Gly Thr Phe Phe Gln Ser Phe Asp Lys Leu Arg 
65                  70                  75                  80  


Pro Ser Leu Thr Ala Gln Leu Thr Gly Glu Gly Glu Cys Asp Thr Glu 
                85                  90                  95      


Arg Lys Asn Val Lys Lys Phe Ile Glu Lys Leu Arg Thr Phe Ile Arg 
            100                 105                 110         


Lys Leu Ser Arg Asp Ala Arg Val 
        115                 120 


<210>  80
<211>  113
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine IL-5 protein.


<400>  80

Val Glu Ser Thr Met Asn Arg Leu Val Ala Glu Thr Leu Thr Leu Leu 
1               5                   10                  15      


Ser Ser His Arg Thr Leu Leu Ile Gly Asp Gly Asn Leu Met Ile Pro 
            20                  25                  30          


Thr Pro Gln His Thr Asn His Gln Leu Cys Ile Glu Glu Val Phe Gln 
        35                  40                  45              


Gly Ile Asp Thr Leu Lys Asn Gln Thr Ala Gln Gly Asp Ala Val Lys 
    50                  55                  60                  


Lys Ile Phe Gln Asn Leu Ser Leu Ile Lys Glu Tyr Ile Asp Leu Gln 
65                  70                  75                  80  


Lys Arg Lys Cys Gly Gly Glu Arg Trp Arg Val Lys Gln Phe Leu Asp 
                85                  90                  95      


Tyr Leu Gln Val Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Met Glu 
            100                 105                 110         


Ser 
    


<210>  81
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-5 protein.


<400>  81

Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu Thr Leu Ala 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu Thr Leu Arg 
            20                  25                  30          


Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr Glu Glu Ile 
        35                  40                  45              


Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln Gly Gly Thr 
    50                  55                  60                  


Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys Tyr Ile Asp 
65                  70                  75                  80  


Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val Asn Gln Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr Glu Trp Ile 
            100                 105                 110         


Ile Glu Ser 
        115 


<210>  82
<211>  112
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-13 protein.


<400>  82

Ser Pro Gly Pro His Ser Arg Arg Glu Leu Lys Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Val Ser Leu Cys Asn Gly Ser Met 
            20                  25                  30          


Val Trp Ser Val Asn Leu Thr Thr Gly Met Tyr Cys Ala Ala Leu Glu 
        35                  40                  45              


Ser Leu Ile Asn Val Ser Asp Cys Thr Ala Ile Gln Arg Thr Gln Arg 
    50                  55                  60                  


Met Leu Lys Ala Leu Cys Thr Gln Lys Pro Ser Ala Gly Gln Thr Ala 
65                  70                  75                  80  


Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile Gln Leu Val Lys 
                85                  90                  95      


Asn Leu Leu Asn His Leu Arg Arg Asn Phe Arg His Gly Asn Phe Lys 
            100                 105                 110         


<210>  83
<211>  113
<212>  PRT
<213>  Sus scrofa

<220>
<223>  This is the amino acid sequence of Pig IL-13 protein.


<400>  83

Ser Pro Gly Pro Val Pro Pro His Ser Thr Ala Leu Lys Glu Leu Ile 
1               5                   10                  15      


Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Thr Pro Leu Cys Asn 
            20                  25                  30          


Gly Ser Met Val Trp Ser Val Asn Leu Thr Thr Ser Met Gln Tyr Cys 
        35                  40                  45              


Ala Ala Leu Glu Ser Leu Ile Asn Ile Ser Asp Cys Ser Ala Ile Gln 
    50                  55                  60                  


Lys Thr Gln Arg Met Leu Ser Ala Leu Cys Ser His Lys Pro Pro Ser 
65                  70                  75                  80  


Glu Gln Val Pro Gly Lys His Ile Arg Asp Thr Lys Ile Glu Val Ala 
                85                  90                  95      


Gln Phe Val Lys Asp Leu Leu Lys His Leu Arg Met Ile Phe Arg His 
            100                 105                 110         


Gly 
    


<210>  84
<211>  101
<212>  PRT
<213>  Gallus gallus

<220>
<223>  This is the amino acid sequence of Chicken IL-13 protein.


<400>  84

Thr Pro Leu Ala Met Asn Leu Ser Lys Leu Lys Leu Ser Asp Ile Thr 
1               5                   10                  15      


Gln Gly Ile Gln Lys Leu Asn Arg Gly Val Gln Leu Ser Glu Gln Glu 
            20                  25                  30          


Leu Leu Cys Gln Ala Ala Thr Val Leu Asp Asn Met Thr Asp Cys Lys 
        35                  40                  45              


Lys Asp Tyr Glu Pro Leu Ile Thr Ser Leu Lys Ser Leu His Gly Met 
    50                  55                  60                  


Thr Asn Cys Pro Pro Ser Thr Asp Asn Glu Ile Tyr Leu Arg Asn Phe 
65                  70                  75                  80  


Leu Pro Ala Leu Gly Asn Tyr Thr Gln Ala Leu Tyr Arg Arg Ile Ser 
                85                  90                  95      


Ala Thr Ala Ala Asn 
            100     


<210>  85
<211>  114
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine IL-13 protein.


<400>  85

Ser Pro Ser Pro Val Pro Ser Ala Thr Ala Leu Lys Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Val Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Leu Asn Leu Thr Ser Ser Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Asp Ser Leu Ile Ser Ile Ser Asn Cys Ser Val Ile Gln Arg Thr 
    50                  55                  60                  


Lys Arg Met Leu Asn Ala Leu Cys Pro His Lys Pro Ser Ala Lys Gln 
65                  70                  75                  80  


Val Ser Ser Glu Tyr Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Leu Lys Asp Leu Leu Arg His Ser Arg Ile Val Phe Arg Asn Glu Arg 
            100                 105                 110         


Phe Asn 
        


<210>  86
<211>  122
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-13 protein.


<400>  86

Leu Thr Cys Leu Gly Gly Phe Ala Ser Pro Gly Pro Val Pro Pro Ser 
1               5                   10                  15      


Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn 
            20                  25                  30          


Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn Leu 
        35                  40                  45              


Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser 
    50                  55                  60                  


Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys 
65                  70                  75                  80  


Pro His Lys Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp 
                85                  90                  95      


Thr Lys Ile Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu 
            100                 105                 110         


Lys Lys Leu Phe Arg Glu Gly Arg Phe Asn 
        115                 120         


<210>  87
<211>  246
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-33 canonical isoform protein.


<400>  87

Met Lys Thr Lys Met Glu Tyr Ser Thr Thr Lys Ile Ser Pro Ala Lys 
1               5                   10                  15      


Met Asn Ser Ser Ala Gly Lys Ala Leu Val Lys Ser Pro Lys Leu Gly 
            20                  25                  30          


Lys Ser Gln Gln Lys Ala Glu Glu Val Cys Gln Met Tyr Phe Met Gln 
        35                  40                  45              


Leu Arg Ser Gly Leu Ile Lys Lys Thr Ala Cys Tyr Phe Lys Lys Glu 
    50                  55                  60                  


Thr Thr Lys Arg His Ser Thr Arg Arg Ala Gly Lys Tyr Lys Glu His 
65                  70                  75                  80  


Leu Val Phe Thr Ala Arg His Gln Gln Leu Glu Arg Pro Val Glu Gly 
                85                  90                  95      


Leu Ala Phe Gly Val Pro Met Val Gln Lys Cys Phe Gly Thr Thr Asp 
            100                 105                 110         


Val Pro Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp 
        115                 120                 125             


Gln Ser Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val 
    130                 135                 140                 


Glu Asp Leu Gly Lys Asp Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr 
145                 150                 155                 160 


Tyr Asp Phe Gln Ser Pro Ser Arg Glu Thr Gly Asp Ala Asp Asp Gly 
                165                 170                 175     


His Thr Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu 
            180                 185                 190         


Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu Gln Lys Cys Lys 
        195                 200                 205             


Lys Pro Leu Pro Asp Gln Ala Phe Phe Arg Leu His Arg Lys Ser Ser 
    210                 215                 220                 


Lys Cys Val Ser Phe Glu Cys Arg Pro Ala Pro Pro Phe Pro Pro Asp 
225                 230                 235                 240 


Leu Arg Ile Leu Gly Arg 
                245     


<210>  88
<211>  117
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of alternative form of Cat IL-33 canonical isoform protein.

<400>  88

Ser Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu 
1               5                   10                  15      


Asp Leu Gly Lys Asp Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr Tyr 
            20                  25                  30          


Asp Phe Gln Ser Pro Ser Arg Glu Thr Gly Asp Ala Asp Asp Gly His 
        35                  40                  45              


Thr Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu 
    50                  55                  60                  


His Ala Asn Asn Lys Glu His Ser Val Glu Leu Gln Lys Cys Lys Lys 
65                  70                  75                  80  


Pro Leu Pro Asp Gln Ala Phe Phe Arg Leu His Arg Lys Ser Ser Lys 
                85                  90                  95      


Cys Val Ser Phe Glu Cys Arg Pro Ala Pro Pro Phe Pro Pro Asp Leu 
            100                 105                 110         


Arg Ile Leu Gly Arg 
        115         


<210>  89
<211>  268
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-33 Isoform 268 aa protein.


<400>  89

Met Lys Thr Lys Met Glu Tyr Ser Thr Thr Lys Ile Ser Pro Ala Lys 
1               5                   10                  15      


Met Asn Ser Ser Ala Gly Lys Ala Leu Val Lys Ser Pro Lys Leu Gly 
            20                  25                  30          


Lys Ser Gln Gln Lys Ala Glu Glu Val Cys Gln Met Tyr Phe Met Gln 
        35                  40                  45              


Leu Arg Ser Gly Leu Ile Lys Lys Thr Ala Cys Tyr Phe Lys Lys Glu 
    50                  55                  60                  


Thr Thr Lys Arg His Ser Thr Arg Arg Ala Gly Lys Tyr Lys Glu His 
65                  70                  75                  80  


Leu Val Phe Thr Ala Arg His Gln Gln Leu Glu Arg Pro Val Glu Gly 
                85                  90                  95      


Leu Ala Phe Gly Val Pro Met Val Gln Lys Cys Phe Gly Thr Thr Asp 
            100                 105                 110         


Val Pro Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp 
        115                 120                 125             


Gln Ser Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val 
    130                 135                 140                 


Glu Asp Leu Gly Lys Asp Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr 
145                 150                 155                 160 


Tyr Asp Phe Gln Ser Pro Ser Arg Glu Thr Gly Asp Ala Asp Asp Gly 
                165                 170                 175     


His Thr Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu 
            180                 185                 190         


Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu Gln Lys Cys Lys 
        195                 200                 205             


Lys Pro Leu Pro Asp Gln Ala Phe Phe Arg Leu His Arg Lys Ser Ser 
    210                 215                 220                 


Lys Cys Val Ser Phe Glu Cys Lys Asn Asp Pro Gly Val Phe Ile Gly 
225                 230                 235                 240 


Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Glu Asp Gln Thr Glu 
                245                 250                 255     


Tyr Phe Ser Thr Glu Asn Ile Ile Phe Lys Leu Ser 
            260                 265             


<210>  90
<211>  139
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of alternative fomr of Cat IL-33 Isoform 268 aa protein.


<400>  90

Ser Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu 
1               5                   10                  15      


Asp Leu Gly Lys Asp Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr Tyr 
            20                  25                  30          


Asp Phe Gln Ser Pro Ser Arg Glu Thr Gly Asp Ala Asp Asp Gly His 
        35                  40                  45              


Thr Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu 
    50                  55                  60                  


His Ala Asn Asn Lys Glu His Ser Val Glu Leu Gln Lys Cys Lys Lys 
65                  70                  75                  80  


Pro Leu Pro Asp Gln Ala Phe Phe Arg Leu His Arg Lys Ser Ser Lys 
                85                  90                  95      


Cys Val Ser Phe Glu Cys Lys Asn Asp Pro Gly Val Phe Ile Gly Val 
            100                 105                 110         


Lys Asp Asn His Leu Ala Leu Ile Lys Val Glu Asp Gln Thr Glu Tyr 
        115                 120                 125             


Phe Ser Thr Glu Asn Ile Ile Phe Lys Leu Ser 
    130                 135                 


<210>  91
<211>  276
<212>  PRT
<213>  Sus scrofa

<220>
<223>  This is the amino acid sequence of Pig IL-33 (K7GS29) protein.


<400>  91

Met Lys Pro Glu Val Lys Tyr Ser Thr Thr Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      


Met Asn Ser Ser Ala Gly Lys Val Ser Ile Lys Ser Pro Lys Leu Arg 
            20                  25                  30          


Lys Ser Gln Gln Lys Ala Lys Glu Val Cys Gln Met Tyr Phe Met Gln 
        35                  40                  45              


Leu Arg Ser Gly Leu Ile Ile Glu Lys Lys Ala Cys Tyr Phe Gly Lys 
    50                  55                  60                  


Glu Thr Thr Lys Arg His Ser Pro Thr Lys Gly Lys Lys Cys Lys Lys 
65                  70                  75                  80  


Gln Pro Leu Val Leu Ala Ala Cys Gln Gln Gln Leu Gly His Leu Glu 
                85                  90                  95      


Arg Ser Val Glu Gly Phe Thr Phe Thr Asn Thr Met Val Gln Lys Tyr 
            100                 105                 110         


Thr Thr Ala Thr Asn Leu Leu Ser Ile Lys Glu His Ser Ala Ser Leu 
        115                 120                 125             


Ser Thr Tyr Asn Asp Gln Tyr Ile Thr Phe Ala Phe Glu Asp Gly Ser 
    130                 135                 140                 


Tyr Glu Ile Tyr Val Glu Asp Leu Arg Lys Asp Gln Glu Lys Asp Lys 
145                 150                 155                 160 


Val Leu Leu Arg Tyr Tyr Asp Ser Gln Ile Pro Ser Ser Glu Thr Asp 
                165                 170                 175     


Gly Gly Gly Asp His Arg Lys Leu Met Val Asn Leu Ser Pro Thr Lys 
            180                 185                 190         


Asp Lys Asp Phe Leu Leu His Ala Asn Ser Lys Glu His Ser Val Glu 
        195                 200                 205             


Leu Gln Lys Cys Glu Asn Pro Leu Pro Glu Gln Ala Phe Phe Val Leu 
    210                 215                 220                 


His Glu Gln Pro Ser Lys Cys Val Ser Phe Glu Cys Lys Ser His Pro 
225                 230                 235                 240 


Gly Val Phe Leu Gly Val Lys Asn Asn Gln Leu Ala Leu Ile Lys Leu 
                245                 250                 255     


Gly Glu His Pro Glu Asp Ser Asn Arg Glu Asn Thr Thr Phe Lys Leu 
            260                 265                 270         


Ser Asn Leu Met 
        275     


<210>  92
<211>  142
<212>  PRT
<213>  Sus scrofa

<220>
<223>  This is the amino acid sequence of Pig IL-33 thought to be the probable mature sequence of K7GS29. 


<400>  92

Tyr Ile Thr Phe Ala Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu 
1               5                   10                  15      


Asp Leu Arg Lys Asp Gln Glu Lys Asp Lys Val Leu Leu Arg Tyr Tyr 
            20                  25                  30          


Asp Ser Gln Ile Pro Ser Ser Glu Thr Asp Gly Gly Gly Asp His Arg 
        35                  40                  45              


Lys Leu Met Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu 
    50                  55                  60                  


His Ala Asn Ser Lys Glu His Ser Val Glu Leu Gln Lys Cys Glu Asn 
65                  70                  75                  80  


Pro Leu Pro Glu Gln Ala Phe Phe Val Leu His Glu Gln Pro Ser Lys 
                85                  90                  95      


Cys Val Ser Phe Glu Cys Lys Ser His Pro Gly Val Phe Leu Gly Val 
            100                 105                 110         


Lys Asn Asn Gln Leu Ala Leu Ile Lys Leu Gly Glu His Pro Glu Asp 
        115                 120                 125             


Ser Asn Arg Glu Asn Thr Thr Phe Lys Leu Ser Asn Leu Met 
    130                 135                 140         


<210>  93
<211>  259
<212>  PRT
<213>  Sus scrofa

<220>
<223>  This is another amino acid sequence of Pig IL-33 (K7GRC7).


<400>  93

Met Lys Pro Glu Val Lys Tyr Ser Thr Thr Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      


Met Asn Ser Ser Ala Gly Lys Val Ser Ile Lys Ser Pro Lys Leu Arg 
            20                  25                  30          


Lys Ser Gln Gln Lys Ala Lys Glu Val Cys Gln Met Tyr Phe Met Gln 
        35                  40                  45              


Leu Arg Ser Gly Leu Ile Ile Glu Lys Lys Ala Cys Tyr Phe Gly Lys 
    50                  55                  60                  


Glu Thr Thr Lys Arg His Ser Pro Thr Lys Gly Lys Lys Cys Lys Lys 
65                  70                  75                  80  


Gln Pro Leu Val Leu Ala Ala Cys Gln Gln Gln Leu Gly His Leu Glu 
                85                  90                  95      


Arg Ser Val Glu Gly Phe Thr Phe Thr Asn Thr Met Val Gln Lys Tyr 
            100                 105                 110         


Thr Thr Ala Thr Asn Leu Leu Ser Ile Lys Glu His Ser Ala Ser Leu 
        115                 120                 125             


Ser Thr Tyr Asn Asp Gln Tyr Ile Thr Phe Ala Phe Glu Asp Gly Ser 
    130                 135                 140                 


Tyr Glu Ile Tyr Val Glu Asp Leu Arg Lys Asp Gln Glu Lys Asp Gly 
145                 150                 155                 160 


Gly Gly Asp His Arg Lys Leu Met Val Asn Leu Ser Pro Thr Lys Asp 
                165                 170                 175     


Lys Asp Phe Leu Leu His Ala Asn Ser Lys Glu His Ser Val Glu Leu 
            180                 185                 190         


Gln Lys Cys Glu Asn Pro Leu Pro Glu Gln Ala Phe Phe Val Leu His 
        195                 200                 205             


Glu Gln Pro Ser Lys Cys Val Ser Phe Glu Cys Lys Ser His Pro Gly 
    210                 215                 220                 


Val Phe Leu Gly Val Lys Asn Asn Gln Leu Ala Leu Ile Lys Leu Gly 
225                 230                 235                 240 


Glu His Pro Glu Asp Ser Asn Arg Glu Asn Thr Thr Phe Lys Leu Ser 
                245                 250                 255     


Asn Leu Met 
            


<210>  94
<211>  125
<212>  PRT
<213>  Sus scrofa

<220>
<223>  This is another amino acid sequence of Pig IL-33 thought to be the probable mature sequence of K7GRC7.


<400>  94

Tyr Ile Thr Phe Ala Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu 
1               5                   10                  15      


Asp Leu Arg Lys Asp Gln Glu Lys Asp Gly Gly Gly Asp His Arg Lys 
            20                  25                  30          


Leu Met Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu His 
        35                  40                  45              


Ala Asn Ser Lys Glu His Ser Val Glu Leu Gln Lys Cys Glu Asn Pro 
    50                  55                  60                  


Leu Pro Glu Gln Ala Phe Phe Val Leu His Glu Gln Pro Ser Lys Cys 
65                  70                  75                  80  


Val Ser Phe Glu Cys Lys Ser His Pro Gly Val Phe Leu Gly Val Lys 
                85                  90                  95      


Asn Asn Gln Leu Ala Leu Ile Lys Leu Gly Glu His Pro Glu Asp Ser 
            100                 105                 110         


Asn Arg Glu Asn Thr Thr Phe Lys Leu Ser Asn Leu Met 
        115                 120                 125 


<210>  95
<211>  273
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine IL-33.


<400>  95

Met Lys Pro Lys Met Lys Tyr Ser Thr Thr Lys Ile Ser Pro Ala Lys 
1               5                   10                  15      


Met Lys Cys Ser Ala Gly Lys Ala Leu Val Lys Ser Pro Lys Leu Arg 
            20                  25                  30          


Lys Ser Gln Gln Lys Ala Glu Glu Val Cys Gln Ile Tyr Tyr Met Gln 
        35                  40                  45              


Leu Arg Ser Gly Leu Lys Ile Glu Lys Lys Val Cys Tyr Phe Arg Lys 
    50                  55                  60                  


Glu Thr Thr Lys Arg His Ser Leu Thr Ala Glu Lys Tyr Lys Glu His 
65                  70                  75                  80  


Leu Ala Leu Val Ala Cys Glu Gln Leu Asn His Leu Gln Gln Ser Val 
                85                  90                  95      


Glu Gln Gly Phe Thr Leu Gly Lys Thr Met Val Pro Tyr Thr Thr Ala 
            100                 105                 110         


Thr Gly Leu Pro Ser Ile Lys Glu His Ser Ala Ser Leu Ser Thr Tyr 
        115                 120                 125             


Asn Asp Gln Phe Ile Thr Phe Val Leu Glu Asp Gly Ser Tyr Glu Ile 
    130                 135                 140                 


Tyr Val Glu Asp Leu Ile Asp Asn Gln Glu Lys Asp Lys Val Leu Leu 
145                 150                 155                 160 


Arg Tyr Tyr Asp Ser Gln Phe Pro Ser Ser Glu Thr Asp Asp Gly Gly 
                165                 170                 175     


Ser His Arg Lys Leu Met Val Asn Leu Ser Pro Thr Lys Asp Lys Asp 
            180                 185                 190         


Phe Leu Leu His Ala Asn Ser Lys Glu His Ser Val Glu Leu Gln Lys 
        195                 200                 205             


Cys Glu Asn Gln Leu Pro Glu Gln Thr Phe Phe Val Leu His Glu Thr 
    210                 215                 220                 


Ser Ser Gln Cys Val Ser Phe Glu Cys Lys Ser Asn Pro Gly Val Phe 
225                 230                 235                 240 


Leu Gly Val Lys Asp Asn Gln Leu Ala Leu Ile Lys Arg Gly Glu His 
                245                 250                 255     


Pro Glu Asp Ser Asn Ser Gln Asn Ile Thr Phe Lys Leu Ser Asn Leu 
            260                 265                 270         


Met 
    


<210>  96
<211>  142
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of the probable mature sequence of Bovine IL-33.


<400>  96

Phe Ile Thr Phe Val Leu Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu 
1               5                   10                  15      


Asp Leu Ile Asp Asn Gln Glu Lys Asp Lys Val Leu Leu Arg Tyr Tyr 
            20                  25                  30          


Asp Ser Gln Phe Pro Ser Ser Glu Thr Asp Asp Gly Gly Ser His Arg 
        35                  40                  45              


Lys Leu Met Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu 
    50                  55                  60                  


His Ala Asn Ser Lys Glu His Ser Val Glu Leu Gln Lys Cys Glu Asn 
65                  70                  75                  80  


Gln Leu Pro Glu Gln Thr Phe Phe Val Leu His Glu Thr Ser Ser Gln 
                85                  90                  95      


Cys Val Ser Phe Glu Cys Lys Ser Asn Pro Gly Val Phe Leu Gly Val 
            100                 105                 110         


Lys Asp Asn Gln Leu Ala Leu Ile Lys Arg Gly Glu His Pro Glu Asp 
        115                 120                 125             


Ser Asn Ser Gln Asn Ile Thr Phe Lys Leu Ser Asn Leu Met 
    130                 135                 140         


<210>  97
<211>  270
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-33 - Full length (1-270).


<400>  97

Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      


Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser 
            20                  25                  30          


Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg 
        35                  40                  45              


Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr 
    50                  55                  60                  


Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu 
65                  70                  75                  80  


Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe 
                85                  90                  95      


Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser 
            100                 105                 110         


Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr 
        115                 120                 125             


Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu 
    130                 135                 140                 


Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu 
145                 150                 155                 160 


Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly 
                165                 170                 175     


Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe 
            180                 185                 190         


Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys 
        195                 200                 205             


Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His 
    210                 215                 220                 


Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile 
225                 230                 235                 240 


Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu 
                245                 250                 255     


Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
            260                 265                 270 


<210>  98
<211>  176
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-33 - Chain 1(95-270).


<400>  98

Ala Phe Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp 
1               5                   10                  15      


Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu 
            20                  25                  30          


Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser 
        35                  40                  45              


Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys 
    50                  55                  60                  


Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly 
65                  70                  75                  80  


Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys 
                85                  90                  95      


Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His 
            100                 105                 110         


Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn 
        115                 120                 125             


Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val 
    130                 135                 140                 


Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser 
145                 150                 155                 160 


Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
                165                 170                 175     


<210>  99
<211>  172
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-33 - Chain 2(99-270).


<400>  99

Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser Ile Thr 
1               5                   10                  15      


Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr Tyr Asn 
            20                  25                  30          


Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu Ile Tyr 
        35                  40                  45              


Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu Leu Ser 
    50                  55                  60                  


Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly Val Asp 
65                  70                  75                  80  


Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe Trp Leu 
                85                  90                  95      


His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys Glu Lys 
            100                 105                 110         


Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His Ser Asn 
        115                 120                 125             


Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile Gly Val 
    130                 135                 140                 


Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu Asn Leu 
145                 150                 155                 160 


Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
                165                 170         


<210>  100
<211>  162
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-33 - Chain 3 (109-270).


<400>  100

His Asp Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala 
1               5                   10                  15      


Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp 
            20                  25                  30          


Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys 
        35                  40                  45              


Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu 
    50                  55                  60                  


Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro 
65                  70                  75                  80  


Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu 
                85                  90                  95      


Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu 
            100                 105                 110         


His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro 
        115                 120                 125             


Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val 
    130                 135                 140                 


Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser 
145                 150                 155                 160 


Glu Thr 
        


<210>  101
<211>  157
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Canine TNF-alpha protein.


<400>  101

Val Lys Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Glu Ala Glu Gly Gln Leu Gln Trp Leu Ser Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Thr Asp Asn Gln Leu 
        35                  40                  45              


Ile Val Pro Ser Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Phe Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Thr Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Leu Pro Asn Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


<210>  102
<211>  157
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Feline TNF-alpha protein.


<400>  102

Leu Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Glu Ala Glu Gly Gln Leu Gln Trp Leu Ser Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Thr Asp Asn Gln Leu 
        35                  40                  45              


Lys Val Pro Ser Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Thr Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Phe Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Thr Glu Ile Asn Leu Pro Ala Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


<210>  103
<211>  153
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine IL1-beta protein.


<400>  103

Ala Pro Val Gln Ser Ile Lys Cys Lys Leu Gln Asp Arg Glu Gln Lys 
1               5                   10                  15      


Ser Leu Val Leu Ala Ser Pro Cys Val Leu Lys Ala Leu His Leu Leu 
            20                  25                  30          


Ser Gln Glu Met Asn Arg Glu Val Val Phe Cys Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Arg Asp Asn Lys Ile Pro Val Ala Leu Gly Ile Lys Asp 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Lys Lys Gly Asp Thr Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Glu Val Asp Pro Lys Val Tyr Pro Lys Arg Asn Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Tyr Lys Thr Glu Ile Lys Asn Thr Val Glu Phe 
            100                 105                 110         


Glu Ser Val Leu Tyr Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ile Glu 
        115                 120                 125             


Glu Arg Pro Val Phe Leu Gly His Phe Arg Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Arg Met Glu Thr Leu Ser Pro 
145                 150             


<210>  104
<211>  152
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Canine IL1-beta protein.


<400>  104

Ala Ala Met Gln Ser Val Asp Cys Lys Leu Gln Asp Ile Ser His Lys 
1               5                   10                  15      


Tyr Leu Val Leu Ser Asn Ser Tyr Glu Leu Arg Ala Leu His Leu Asn 
            20                  25                  30          


Gly Glu Asn Val Asn Lys Gln Val Val Phe His Met Ser Phe Val His 
        35                  40                  45              


Gly Asp Glu Ser Asn Asn Lys Ile Pro Val Val Leu Gly Ile Lys Gln 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Lys Val Asp Pro Lys Val Tyr Pro Lys Arg Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Lys Asn Thr Val Glu Phe 
            100                 105                 110         


Glu Ser Ser Gln Tyr Pro Asn Trp Tyr Ile Ser Thr Ser Gln Val Glu 
        115                 120                 125             


Gly Met Pro Val Phe Leu Gly Asn Thr Arg Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Thr Met Glu Phe Ser Ser 
145                 150         


<210>  105
<211>  152
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Feline IL1-beta protein.


<400>  105

Ala Ala Ile Gln Ser Gln Asp Tyr Thr Phe Arg Asp Ile Ser Gln Lys 
1               5                   10                  15      


Ser Leu Val Leu Ser Gly Ser Tyr Glu Leu Arg Ala Leu His Leu Asn 
            20                  25                  30          


Gly Gln Asn Met Asn Gln Gln Val Val Phe Arg Met Ser Phe Val His 
        35                  40                  45              


Gly Glu Glu Asn Ser Lys Lys Ile Pro Val Val Leu Cys Ile Lys Lys 
    50                  55                  60                  


Asn Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Met Leu Asp Pro Lys Val Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Thr Glu Ile Lys Gly Asn Val Glu Phe 
            100                 105                 110         


Glu Ser Ser Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala Glu 
        115                 120                 125             


Glu Met Pro Val Phe Leu Gly Asn Thr Lys Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Ile Met Glu Ser Ala Ser 
145                 150         


<210>  106
<211>  135
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-2 protein.


<400>  106

Ala Pro Ile Thr Ser Ser Ser Thr Lys Glu Thr Glu Gln Gln Met Glu 
1               5                   10                  15      


Gln Leu Leu Leu Asp Leu Gln Leu Leu Leu Asn Gly Val Asn Asn Tyr 
            20                  25                  30          


Glu Asn Pro Gln Leu Ser Arg Met Leu Thr Phe Lys Phe Tyr Thr Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Phe Thr His Leu Gln Cys Leu Ala Glu Glu Leu 
    50                  55                  60                  


Lys Asn Leu Glu Glu Val Leu Gly Leu Pro Gln Ser Lys Asn Val His 
65                  70                  75                  80  


Leu Thr Asp Thr Lys Glu Leu Ile Ser Asn Met Asn Val Thr Leu Leu 
                85                  90                  95      


Lys Leu Lys Gly Ser Glu Thr Ser Tyr Asn Cys Glu Tyr Asp Asp Glu 
            100                 105                 110         


Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys Trp Ile Thr Phe Cys Gln 
        115                 120                 125             


Ser Ile Phe Ser Thr Leu Thr 
    130                 135 


<210>  107
<211>  134
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-2 protein.


<400>  107

Ala Pro Ala Ser Ser Ser Thr Lys Glu Thr Gln Gln Gln Leu Glu Gln 
1               5                   10                  15      


Leu Leu Leu Asp Leu Arg Leu Leu Leu Asn Gly Val Asn Asn Pro Glu 
            20                  25                  30          


Asn Pro Lys Leu Ser Arg Met Leu Thr Phe Lys Phe Tyr Val Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Thr His Leu Gln Cys Leu Val Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Tyr Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Asn His Ile Lys Glu Leu Met Ser Asn Ile Asn Val Thr Val Leu Lys 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Arg Phe Thr Cys Asn Tyr Asp Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Lys Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Phe Ser Thr Leu Thr 
    130                 


<210>  108
<211>  133
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-2 protein.


<400>  108

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  109
<211>  120
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-3 protein.


<400>  109

Arg Pro Phe Ser Thr Asp Leu Pro Lys Gln Tyr Phe Thr Met Ile Asn 
1               5                   10                  15      


Glu Ile Met Glu Met Leu Asn Lys Ser Pro Ser Pro Ser Glu Glu Pro 
            20                  25                  30          


Leu Asp Ser Asn Glu Lys Glu Thr Leu Leu Glu Asp Thr Leu Leu Arg 
        35                  40                  45              


Pro Asn Leu Asp Val Phe Leu Asn Ala Ser Ser Lys Phe His Lys Asn 
    50                  55                  60                  


Gly Leu Leu Ile Trp Asn Asn Leu Lys Glu Phe Leu Pro Leu Leu Pro 
65                  70                  75                  80  


Thr Pro Thr Pro Arg Gly Glu Pro Ile Ser Ile Met Glu Asn Asn Trp 
                85                  90                  95      


Gly Asp Phe Gln Arg Lys Leu Lys Lys Tyr Leu Glu Ala Leu Asp Asn 
            100                 105                 110         


Phe Leu Asn Phe Lys Asn Lys Pro 
        115                 120 


<210>  110
<211>  133
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-3 protein.


<400>  110

Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp Val Asn Cys 
1               5                   10                  15      


Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu 
            20                  25                  30          


Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu 
        35                  40                  45              


Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala 
    50                  55                  60                  


Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn 
65                  70                  75                  80  


Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro 
                85                  90                  95      


Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr 
            100                 105                 110         


Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu 
        115                 120                 125             


Ser Leu Ala Ile Phe 
    130             


<210>  111
<211>  187
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-6 protein.


<400>  111

Phe Pro Thr Pro Gly Pro Leu Ala Gly Asp Ser Lys Asp Asp Ala Thr 
1               5                   10                  15      


Ser Asn Ser Leu Pro Leu Thr Ser Ala Asn Lys Val Glu Glu Leu Ile 
            20                  25                  30          


Lys Tyr Ile Leu Gly Lys Ile Ser Ala Leu Arg Lys Glu Met Cys Asp 
        35                  40                  45              


Lys Phe Asn Lys Cys Glu Asp Ser Lys Glu Ala Leu Ala Glu Asn Asn 
    50                  55                  60                  


Leu His Leu Pro Lys Leu Glu Gly Lys Asp Gly Cys Phe Gln Ser Gly 
65                  70                  75                  80  


Phe Asn Gln Glu Thr Cys Leu Thr Arg Ile Thr Thr Gly Leu Val Glu 
                85                  90                  95      


Phe Gln Leu His Leu Asn Ile Leu Gln Asn Asn Tyr Glu Gly Asp Lys 
            100                 105                 110         


Glu Asn Val Lys Ser Val His Met Ser Thr Lys Ile Leu Val Gln Met 
        115                 120                 125             


Leu Lys Ser Lys Val Lys Asn Gln Asp Glu Val Thr Thr Pro Asp Pro 
    130                 135                 140                 


Thr Thr Asp Ala Ser Leu Gln Ala Ile Leu Gln Ser Gln Asp Glu Cys 
145                 150                 155                 160 


Val Lys His Thr Thr Ile His Leu Ile Leu Arg Ser Leu Glu Asp Phe 
                165                 170                 175     


Leu Gln Phe Ser Leu Arg Ala Val Arg Ile Met 
            180                 185         


<210>  112
<211>  181
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-6 protein.


<400>  112

Thr Pro Gly Pro Leu Gly Gly Asp Ala Thr Ser Asn Arg Leu Pro Leu 
1               5                   10                  15      


Thr Ser Ala Asp Lys Met Glu Glu Leu Ile Lys Tyr Ile Leu Gly Lys 
            20                  25                  30          


Ile Ser Ala Leu Lys Lys Glu Met Cys Asp Asn Tyr Asn Lys Cys Glu 
        35                  40                  45              


Asp Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Leu 
    50                  55                  60                  


Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Gln Glu Thr Cys 
65                  70                  75                  80  


Leu Thr Arg Ile Thr Thr Gly Leu Gln Glu Phe Gln Ile Tyr Leu Lys 
                85                  90                  95      


Phe Leu Gln Asp Lys Tyr Glu Gly Asp Glu Glu Asn Ala Lys Ser Val 
            100                 105                 110         


Tyr Thr Ser Thr Asn Val Leu Leu Gln Met Leu Lys Arg Lys Gly Lys 
        115                 120                 125             


Asn Gln Asp Glu Val Thr Ile Pro Val Pro Thr Val Glu Val Gly Leu 
    130                 135                 140                 


Gln Ala Lys Leu Gln Ser Gln Glu Glu Trp Leu Arg His Thr Thr Ile 
145                 150                 155                 160 


His Leu Thr Leu Arg Arg Leu Glu Asp Phe Leu Gln Phe Ser Leu Arg 
                165                 170                 175     


Ala Val Arg Ile Met 
            180     


<210>  113
<211>  179
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine IL-6 protein.


<400>  113

Gly Pro Leu Gly Glu Asp Phe Lys Asn Asp Thr Thr Pro Gly Arg Leu 
1               5                   10                  15      


Leu Leu Thr Thr Pro Glu Lys Thr Glu Ala Leu Ile Lys Arg Met Val 
            20                  25                  30          


Asp Lys Ile Ser Ala Met Arg Lys Glu Ile Cys Glu Lys Asn Asp Glu 
        35                  40                  45              


Cys Glu Ser Ser Lys Glu Thr Leu Ala Glu Asn Lys Leu Asn Leu Pro 
    50                  55                  60                  


Lys Met Glu Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Gln Ala 
65                  70                  75                  80  


Ile Cys Leu Ile Arg Thr Thr Ala Gly Leu Leu Glu Tyr Gln Ile Tyr 
                85                  90                  95      


Leu Asp Tyr Leu Gln Asn Glu Tyr Glu Gly Asn Gln Glu Asn Val Arg 
            100                 105                 110         


Asp Leu Arg Lys Asn Ile Arg Thr Leu Ile Gln Ile Leu Lys Gln Lys 
        115                 120                 125             


Ile Ala Asp Leu Ile Thr Thr Pro Ala Thr Asn Thr Asp Leu Leu Glu 
    130                 135                 140                 


Lys Met Gln Ser Ser Asn Glu Trp Val Lys Asn Ala Lys Ile Ile Leu 
145                 150                 155                 160 


Ile Leu Arg Asn Leu Glu Asn Phe Leu Gln Phe Ser Leu Arg Ala Ile 
                165                 170                 175     


Arg Met Lys 
            


<210>  114
<211>  183
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-6 protein.


<400>  114

Val Pro Pro Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln 
1               5                   10                  15      


Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu 
            20                  25                  30          


Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met 
        35                  40                  45              


Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro 
    50                  55                  60                  


Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu 
65                  70                  75                  80  


Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr 
                85                  90                  95      


Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg 
            100                 105                 110         


Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys 
        115                 120                 125             


Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala 
    130                 135                 140                 


Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met 
145                 150                 155                 160 


Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser 
                165                 170                 175     


Leu Arg Ala Leu Arg Gln Met 
            180             


<210>  115
<211>  152
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-7 protein.


<400>  115

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210>  116
<211>  79
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-8 protein.


<400>  116

Ala Val Leu Ser Arg Val Ser Ser Glu Leu Arg Cys Gln Cys Ile Lys 
1               5                   10                  15      


Thr His Ser Thr Pro Phe His Pro Lys Tyr Ile Lys Glu Leu Arg Val 
            20                  25                  30          


Ile Asp Ser Gly Pro His Cys Glu Asn Ser Glu Ile Ile Val Lys Leu 
        35                  40                  45              


Phe Asn Gly Asn Glu Val Cys Leu Asp Pro Lys Glu Lys Trp Val Gln 
    50                  55                  60                  


Lys Val Val Gln Ile Phe Leu Lys Lys Ala Glu Lys Gln Asp Pro 
65                  70                  75                  


<210>  117
<211>  79
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-8 protein.


<400>  117

Ala Val Leu Ser Arg Ile Ser Ser Glu Leu Arg Cys Gln Cys Ile Lys 
1               5                   10                  15      


Thr His Ser Thr Pro Phe Asn Pro Lys Leu Ile Lys Glu Leu Thr Val 
            20                  25                  30          


Ile Asp Ser Gly Pro His Cys Glu Asn Ser Glu Ile Ile Val Lys Leu 
        35                  40                  45              


Val Asn Gly Lys Glu Val Cys Leu Asp Pro Lys Gln Lys Trp Val Gln 
    50                  55                  60                  


Lys Val Val Glu Ile Phe Leu Lys Lys Ala Glu Lys Gln Asn Ala 
65                  70                  75                  


<210>  118
<211>  79
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine IL-8 protein.


<400>  118

Ala Val Leu Ser Arg Met Ser Thr Glu Leu Arg Cys Gln Cys Ile Lys 
1               5                   10                  15      


Thr His Ser Thr Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val 
            20                  25                  30          


Ile Glu Ser Gly Pro His Cys Glu Asn Ser Glu Ile Ile Val Lys Leu 
        35                  40                  45              


Thr Asn Gly Asn Glu Val Cys Leu Asn Pro Lys Glu Lys Trp Val Gln 
    50                  55                  60                  


Lys Val Val Gln Val Phe Val Lys Arg Ala Glu Lys Gln Asp Pro 
65                  70                  75                  


<210>  119
<211>  79
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-8 - aa 21-99 protein.


<400>  119

Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys 
1               5                   10                  15      


Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu 
            20                  25                  30          


Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val 
        35                  40                  45              


Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp 
    50                  55                  60                  


Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser 
65                  70                  75                  


<210>  120
<211>  77
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-8 - aa 23-99 protein.


<400>  120

Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys 
1               5                   10                  15      


Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val 
            20                  25                  30          


Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu 
        35                  40                  45              


Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln 
    50                  55                  60                  


Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser 
65                  70                  75          


<210>  121
<211>  73
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-8 - aa 27-99 protein.


<400>  121

Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys 
1               5                   10                  15      


Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly 
            20                  25                  30          


Pro His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg 
        35                  40                  45              


Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu 
    50                  55                  60                  


Lys Phe Leu Lys Arg Ala Glu Asn Ser 
65                  70              


<210>  122
<211>  72
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-8 - aa 28-99 protein.


<400>  122

Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro 
1               5                   10                  15      


Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro 
            20                  25                  30          


His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu 
        35                  40                  45              


Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys 
    50                  55                  60                  


Phe Leu Lys Arg Ala Glu Asn Ser 
65                  70          


<210>  123
<211>  71
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-8 - aa 29-99 protein.


<400>  123

Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe 
1               5                   10                  15      


His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His 
            20                  25                  30          


Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu 
        35                  40                  45              


Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe 
    50                  55                  60                  


Leu Lys Arg Ala Glu Asn Ser 
65                  70      


<210>  124
<211>  70
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-8 - aa 30-99 protein.


<400>  124

Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His 
1               5                   10                  15      


Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys 
            20                  25                  30          


Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys 
        35                  40                  45              


Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu 
    50                  55                  60                  


Lys Arg Ala Glu Asn Ser 
65                  70  


<210>  125
<211>  69
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-8 - aa 31-99 protein.


<400>  125

Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro 
1               5                   10                  15      


Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala 
            20                  25                  30          


Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu 
        35                  40                  45              


Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys 
    50                  55                  60                  


Arg Ala Glu Asn Ser 
65                  


<210>  126
<211>  126
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-9 protein.


<400>  126

Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile 
1               5                   10                  15      


Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn 
            20                  25                  30          


Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg 
        35                  40                  45              


Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln 
    50                  55                  60                  


Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val 
65                  70                  75                  80  


Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn 
                85                  90                  95      


Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu 
            100                 105                 110         


Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
        115                 120                 125     


<210>  127
<211>  162
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-10 protein.


<400>  127

Ser Arg His Gln Ser Thr Leu Leu Glu Asp Asp Cys Thr His Phe Pro 
1               5                   10                  15      


Ala Ser Leu Pro His Met Leu Arg Glu Leu Arg Ala Ala Phe Gly Arg 
            20                  25                  30          


Val Lys Ile Phe Phe Gln Met Lys Asp Lys Leu Asp Asn Ile Leu Leu 
        35                  40                  45              


Thr Gly Ser Leu Leu Glu Asp Phe Lys Ser Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Arg Ala 
65                  70                  75                  80  


Glu Asn His Asp Pro Asp Ile Lys Asn His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Lys Leu Lys Thr Leu Arg Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
            100                 105                 110         


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
        115                 120                 125             


Ala Phe Ser Lys Leu Gln Glu Lys Gly Val Tyr Lys Ala Met Ser Glu 
    130                 135                 140                 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Thr Tyr Met Thr Met Arg Met 
145                 150                 155                 160 


Lys Ile 
        


<210>  128
<211>  160
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-10 protein.


<400>  128

Ser Arg His Gln Ser Thr Leu Ser Glu Asp Asn Cys Thr His Phe Ser 
1               5                   10                  15      


Val Ser Leu Pro His Met Leu Arg Glu Leu Arg Ala Ala Phe Gly Lys 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu His Ser Ile Leu Leu 
        35                  40                  45              


Thr Arg Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Glu Asp Pro Asp Ile Lys Gln His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Lys Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Val Val Glu Gln Val Lys Ser Thr Phe 
        115                 120                 125             


Ser Lys Leu Gln Glu Lys Gly Val Tyr Lys Ala Met Gly Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Met Lys Ile 
145                 150                 155                 160 


<210>  129
<211>  160
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-10 protein.


<400>  129

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210>  130
<211>  178
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-11 protein.


<400>  130

Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser Pro Asp Pro Arg Ala 
1               5                   10                  15      


Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser Leu Leu Ala Asp Thr 
            20                  25                  30          


Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe Pro Ala Asp Gly Asp 
        35                  40                  45              


His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met Ser Ala Gly Ala Leu 
    50                  55                  60                  


Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg Leu Arg Ala Asp Leu 
65                  70                  75                  80  


Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg Arg Ala Gly Gly Ser 
                85                  90                  95      


Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr Leu Gln Ala Arg Leu 
            100                 105                 110         


Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met Ser Arg Leu Ala Leu 
        115                 120                 125             


Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro Leu Ala Pro Pro Ser 
    130                 135                 140                 


Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala Ile Leu Gly Gly Leu 
145                 150                 155                 160 


His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu Leu Leu Leu Lys Thr 
                165                 170                 175     


Arg Leu 
        


<210>  131
<211>  546
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-14 protein.


<400>  131

Met Lys Asn Gln Asp Lys Lys Asn Gly Ala Ala Lys Gln Ser Asn Pro 
1               5                   10                  15      


Lys Ser Ser Pro Gly Gln Pro Glu Ala Gly Pro Glu Gly Ala Gln Glu 
            20                  25                  30          


Arg Pro Ser Gln Ala Ala Pro Ala Val Glu Ala Glu Gly Pro Gly Ser 
        35                  40                  45              


Ser Gln Ala Pro Arg Lys Pro Glu Gly Ala Gln Ala Arg Thr Ala Gln 
    50                  55                  60                  


Ser Gly Ala Leu Arg Asp Val Ser Glu Glu Leu Ser Arg Gln Leu Glu 
65                  70                  75                  80  


Asp Ile Leu Ser Thr Tyr Cys Val Asp Asn Asn Gln Gly Gly Pro Gly 
                85                  90                  95      


Glu Asp Gly Ala Gln Gly Glu Pro Ala Glu Pro Glu Asp Ala Glu Lys 
            100                 105                 110         


Ser Arg Thr Tyr Val Ala Arg Asn Gly Glu Pro Glu Pro Thr Pro Val 
        115                 120                 125             


Val Asn Gly Glu Lys Glu Pro Ser Lys Gly Asp Pro Asn Thr Glu Glu 
    130                 135                 140                 


Ile Arg Gln Ser Asp Glu Val Gly Asp Arg Asp His Arg Arg Pro Gln 
145                 150                 155                 160 


Glu Lys Lys Lys Ala Lys Gly Leu Gly Lys Glu Ile Thr Leu Leu Met 
                165                 170                 175     


Gln Thr Leu Asn Thr Leu Ser Thr Pro Glu Glu Lys Leu Ala Ala Leu 
            180                 185                 190         


Cys Lys Lys Tyr Ala Glu Leu Leu Glu Glu His Arg Asn Ser Gln Lys 
        195                 200                 205             


Gln Met Lys Leu Leu Gln Lys Lys Gln Ser Gln Leu Val Gln Glu Lys 
    210                 215                 220                 


Asp His Leu Arg Gly Glu His Ser Lys Ala Val Leu Ala Arg Ser Lys 
225                 230                 235                 240 


Leu Glu Ser Leu Cys Arg Glu Leu Gln Arg His Asn Arg Ser Leu Lys 
                245                 250                 255     


Glu Glu Gly Val Gln Arg Ala Arg Glu Glu Glu Glu Lys Arg Lys Glu 
            260                 265                 270         


Val Thr Ser His Phe Gln Val Thr Leu Asn Asp Ile Gln Leu Gln Met 
        275                 280                 285             


Glu Gln His Asn Glu Arg Asn Ser Lys Leu Arg Gln Glu Asn Met Glu 
    290                 295                 300                 


Leu Ala Glu Arg Leu Lys Lys Leu Ile Glu Gln Tyr Glu Leu Arg Glu 
305                 310                 315                 320 


Glu His Ile Asp Lys Val Phe Lys His Lys Asp Leu Gln Gln Gln Leu 
                325                 330                 335     


Val Asp Ala Lys Leu Gln Gln Ala Gln Glu Met Leu Lys Glu Ala Glu 
            340                 345                 350         


Glu Arg His Gln Arg Glu Lys Asp Phe Leu Leu Lys Glu Ala Val Glu 
        355                 360                 365             


Ser Gln Arg Met Cys Glu Leu Met Lys Gln Gln Glu Thr His Leu Lys 
    370                 375                 380                 


Gln Gln Leu Ala Leu Tyr Thr Glu Lys Phe Glu Glu Phe Gln Asn Thr 
385                 390                 395                 400 


Leu Ser Lys Ser Ser Glu Val Phe Thr Thr Phe Lys Gln Glu Met Glu 
                405                 410                 415     


Lys Met Thr Lys Lys Ile Lys Lys Leu Glu Lys Glu Thr Thr Met Tyr 
            420                 425                 430         


Arg Ser Arg Trp Glu Ser Ser Asn Lys Ala Leu Leu Glu Met Ala Glu 
        435                 440                 445             


Glu Lys Thr Val Arg Asp Lys Glu Leu Glu Gly Leu Gln Val Lys Ile 
    450                 455                 460                 


Gln Arg Leu Glu Lys Leu Cys Arg Ala Leu Gln Thr Glu Arg Asn Asp 
465                 470                 475                 480 


Leu Asn Lys Arg Val Gln Asp Leu Ser Ala Gly Gly Gln Gly Ser Leu 
                485                 490                 495     


Thr Asp Ser Gly Pro Glu Arg Arg Pro Glu Gly Pro Gly Ala Gln Ala 
            500                 505                 510         


Pro Ser Ser Pro Arg Val Thr Glu Ala Pro Cys Tyr Pro Gly Ala Pro 
        515                 520                 525             


Ser Thr Glu Ala Ser Gly Gln Thr Gly Pro Gln Glu Pro Thr Ser Ala 
    530                 535                 540                 


Arg Ala 
545     


<210>  132
<211>  114
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-15 protein.


<400>  132

Asn Trp Gln Asp Val Ile Ser Asp Leu Lys Ile Ile Asp Lys Ile Ile 
1               5                   10                  15      


Gln Ser Leu His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Asn Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu His 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Lys Asn Glu Thr Ile His Gln Thr Val Glu 
    50                  55                  60                  


Asn Ile Ile Ile Leu Ala Asn Ser Gly Leu Ser Ser Asn Arg Asn Ile 
65                  70                  75                  80  


Thr Glu Thr Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  133
<211>  114
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-15 protein.


<400>  133

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  134
<211>  1332
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-16 - 1-1332 aa protein.


<400>  134

Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      


Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          


Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              


Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  


Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      


Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         


Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             


Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 


Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     


Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         


Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             


Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 


Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 


Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     


Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         


Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             


Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 


Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 


Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     


Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         


Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             


Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 


His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 


Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     


Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 
            420                 425                 430         


Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             


Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 


Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 


Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     


Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         


Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             


Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 


Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 


Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     


Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 
            580                 585                 590         


Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 
        595                 600                 605             


Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 
    610                 615                 620                 


Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 
625                 630                 635                 640 


Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 
                645                 650                 655     


Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 
            660                 665                 670         


Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 
        675                 680                 685             


Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 
    690                 695                 700                 


Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 
705                 710                 715                 720 


Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 
                725                 730                 735     


Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 
            740                 745                 750         


His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 
        755                 760                 765             


Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 
    770                 775                 780                 


Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 
                805                 810                 815     


Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 
            820                 825                 830         


Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 
        835                 840                 845             


Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 
    850                 855                 860                 


Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 
865                 870                 875                 880 


Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 
                885                 890                 895     


Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 
            900                 905                 910         


Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 
        915                 920                 925             


Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 
    930                 935                 940                 


Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 
945                 950                 955                 960 


Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 
                965                 970                 975     


Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 
            980                 985                 990         


Gln Val Ser Ser Ala Val Met Lys  Ser Leu Leu Cys Leu  Pro Ser Ser 
        995                 1000                 1005             


Ile Ser  Cys Ala Gln Thr Pro  Cys Ile Pro Lys Glu  Gly Ala Ser 
    1010                 1015                 1020             


Pro Thr  Ser Ser Ser Asn Glu  Asp Ser Ala Ala Asn  Gly Ser Ala 
    1025                 1030                 1035             


Glu Thr  Ser Ala Leu Asp Thr  Gly Phe Ser Leu Asn  Leu Ser Glu 
    1040                 1045                 1050             


Leu Arg  Glu Tyr Thr Glu Gly  Leu Thr Glu Ala Lys  Glu Asp Asp 
    1055                 1060                 1065             


Asp Gly  Asp His Ser Ser Leu  Gln Ser Gly Gln Ser  Val Ile Ser 
    1070                 1075                 1080             


Leu Leu  Ser Ser Glu Glu Leu  Lys Lys Leu Ile Glu  Glu Val Lys 
    1085                 1090                 1095             


Val Leu  Asp Glu Ala Thr Leu  Lys Gln Leu Asp Gly  Ile His Val 
    1100                 1105                 1110             


Thr Ile  Leu His Lys Glu Glu  Gly Ala Gly Leu Gly  Phe Ser Leu 
    1115                 1120                 1125             


Ala Gly  Gly Ala Asp Leu Glu  Asn Lys Val Ile Thr  Val His Arg 
    1130                 1135                 1140             


Val Phe  Pro Asn Gly Leu Ala  Ser Gln Glu Gly Thr  Ile Gln Lys 
    1145                 1150                 1155             


Gly Asn  Glu Val Leu Ser Ile  Asn Gly Lys Ser Leu  Lys Gly Thr 
    1160                 1165                 1170             


Thr His  His Asp Ala Leu Ala  Ile Leu Arg Gln Ala  Arg Glu Pro 
    1175                 1180                 1185             


Arg Gln  Ala Val Ile Val Thr  Arg Lys Leu Thr Pro  Glu Ala Met 
    1190                 1195                 1200             


Pro Asp  Leu Asn Ser Ser Thr  Asp Ser Ala Ala Ser  Ala Ser Ala 
    1205                 1210                 1215             


Ala Ser  Asp Val Ser Val Glu  Ser Thr Ala Glu Ala  Thr Val Cys 
    1220                 1225                 1230             


Thr Val  Thr Leu Glu Lys Met  Ser Ala Gly Leu Gly  Phe Ser Leu 
    1235                 1240                 1245             


Glu Gly  Gly Lys Gly Ser Leu  His Gly Asp Lys Pro  Leu Thr Ile 
    1250                 1255                 1260             


Asn Arg  Ile Phe Lys Gly Ala  Ala Ser Glu Gln Ser  Glu Thr Val 
    1265                 1270                 1275             


Gln Pro  Gly Asp Glu Ile Leu  Gln Leu Gly Gly Thr  Ala Met Gln 
    1280                 1285                 1290             


Gly Leu  Thr Arg Phe Glu Ala  Trp Asn Ile Ile Lys  Ala Leu Pro 
    1295                 1300                 1305             


Asp Gly  Pro Val Thr Ile Val  Ile Arg Arg Lys Ser  Leu Gln Ser 
    1310                 1315                 1320             


Lys Glu  Thr Thr Ala Ala Gly  Asp Ser 
    1325                 1330         


<210>  135
<211>  121
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-16 - 1212-1332 aa protein.


<400>  135

Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 
1               5                   10                  15      


Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 
            20                  25                  30          


Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 
        35                  40                  45              


Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 
    50                  55                  60                  


Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 
                85                  90                  95      


Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 
            100                 105                 110         


Lys Glu Thr Thr Ala Ala Gly Asp Ser 
        115                 120     


<210>  136
<211>  127
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-17A protein.


<400>  136

Phe Pro Gln Asn Pro Gly Cys Arg Asn Thr Glu Asp Lys Asn Phe Pro 
1               5                   10                  15      


Gln His Val Lys Val Asn Leu Asn Ile Leu Asn Arg Asn Thr Asn Ser 
            20                  25                  30          


Arg Arg Pro Ser Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu 
        35                  40                  45              


His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala 
    50                  55                  60                  


Lys Cys Arg His Leu Gly Cys Val Asn Asn Glu Gly Asn Ile Asn Tyr 
65                  70                  75                  80  


His Met Asn Ser Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg 
                85                  90                  95      


Glu Ser Gln His Cys Pro His Ser Phe Arg Leu Glu Lys Met Leu Val 
            100                 105                 110         


Ala Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg His Val Ala 
        115                 120                 125         


<210>  137
<211>  127
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-17A protein.


<400>  137

Phe Pro Gln Asn Pro Gly Cys Pro Thr Thr Glu Asp Lys Asn Phe Pro 
1               5                   10                  15      


Gln His Val Lys Val Asn Val Asn Ile Leu Asn Gly Asn Lys Ser Ser 
            20                  25                  30          


Arg Arg Pro Leu Asp Tyr Tyr Arg Arg Ser Thr Ser Pro Trp Ser Leu 
        35                  40                  45              


His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala 
    50                  55                  60                  


Lys Cys Leu His Trp Gly Cys Val Asn Thr Glu Gly Lys Glu Asp His 
65                  70                  75                  80  


His Met Asn Ser Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg 
                85                  90                  95      


Glu Ser Arg His Cys Pro His Ser Phe Arg Leu Glu Lys Met Leu Val 
            100                 105                 110         


Thr Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg His Val Val 
        115                 120                 125         


<210>  138
<211>  158
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-17B protein.


<400>  138

Arg Asn Pro Lys Gly Lys Arg Lys Gly Pro Gly Arg Pro Gly Thr Leu 
1               5                   10                  15      


Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Gln Ala Lys 
            20                  25                  30          


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Leu Ser Glu Met Val 
        35                  40                  45              


Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala Arg Arg Lys Cys Glu Val 
    50                  55                  60                  


Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg Ser Leu Ser Pro Trp Gly 
65                  70                  75                  80  


Tyr Ser Ile Asn His Asp Pro Ser Arg Val Pro Ala Asp Leu Pro Glu 
                85                  90                  95      


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
            100                 105                 110         


Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
        115                 120                 125             


Arg Arg Leu Cys Pro Leu Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
    130                 135                 140                 


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe 
145                 150                 155             


<210>  139
<211>  158
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-17B protein.


<400>  139

Arg Asn Pro Lys Gly Lys Arg Lys Gly Pro Gly Arg Pro Gly Thr Leu 
1               5                   10                  15      


Ala Ser Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Gln Ala Lys 
            20                  25                  30          


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Leu Gly Glu Met Val 
        35                  40                  45              


Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala Arg Arg Lys Cys Glu Val 
    50                  55                  60                  


Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg Ser Leu Ser Pro Trp Gly 
65                  70                  75                  80  


Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Ala Asp Leu Pro Glu 
                85                  90                  95      


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
            100                 105                 110         


Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
        115                 120                 125             


Arg Arg Leu Cys Pro Leu Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
    130                 135                 140                 


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe 
145                 150                 155             


<210>  140
<211>  160
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-17B protein.


<400>  140

Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln Gly Arg Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Arg 
            20                  25                  30          


Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Ile Glu Glu 
        35                  40                  45              


Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala Gln Arg Lys Cys 
    50                  55                  60                  


Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg Ser Leu Ser Pro 
65                  70                  75                  80  


Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu 
                85                  90                  95      


Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met 
            100                 105                 110         


Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro 
        115                 120                 125             


Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr Gly Pro Cys Arg 
    130                 135                 140                 


Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe 
145                 150                 155                 160 


<210>  141
<211>  179
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-17C protein.


<400>  141

Arg His Gly Pro Gln Leu Trp Arg Gly Leu His Thr His Gly Thr Pro 
1               5                   10                  15      


Arg Cys Tyr Ser Ala Glu Glu Leu Pro Arg Gly Gln Ala Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Ala Ala Lys Trp Glu Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Gly Gly Arg Gly Arg Glu Gln Asp Gly Pro 
    50                  55                  60                  


Pro Ala Gly Ala Gln Cys Pro Val Leu Gln Pro Glu Glu Val Leu Glu 
65                  70                  75                  80  


Ala Asp Ile His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Ser Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Ile Ser Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Asn Ser Val Pro Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Arg Pro 
    130                 135                 140                 


Cys Ser Arg Asp Thr Thr Gly Leu Pro Thr Pro Gly Ala Phe Ser Phe 
145                 150                 155                 160 


His Ala Glu Phe Ile Arg Val Pro Ile Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Thr 
            


<210>  142
<211>  180
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-17C protein.


<400>  142

Arg His Gly Pro Gln Leu Trp Gly Gly Pro His Ala His Gly Thr Pro 
1               5                   10                  15      


Arg Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Pro Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Ala Ala Lys Trp Glu Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Gly Gly Arg Arg Arg Arg His Asp Gly Pro 
    50                  55                  60                  


Pro Ala Gly Thr Gln Cys Pro Val Leu Arg Pro Glu Asp Val Leu Glu 
65                  70                  75                  80  


Ala Gly Ile His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Ser Arg Tyr Pro Gln Lys Leu Ala Phe Ala Gln Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Val Ser Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Asn Ser Val Pro Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Gln Pro 
    130                 135                 140                 


Cys Ser Arg Glu Ala Thr Gly Leu Pro Thr Pro Gly Ala Phe Ser Phe 
145                 150                 155                 160 


His Ala Glu Phe Ile Arg Val Pro Val Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg 
            180 


<210>  143
<211>  179
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-17C protein.


<400>  143

His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly Thr Pro 
1               5                   10                  15      


His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu Arg Pro 
    50                  55                  60                  


Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val Leu Glu 
65                  70                  75                  80  


Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Arg Pro 
    130                 135                 140                 


Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe Ala Phe 
145                 150                 155                 160 


His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Val 
            


<210>  144
<211>  185
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-17D protein.


<400>  144

Ala Leu Arg Ala Ser Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala Glu 
1               5                   10                  15      


Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala Gly 
            20                  25                  30          


Val Leu Gly Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu Gln 
        35                  40                  45              


Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Gly Asp Arg Arg 
    50                  55                  60                  


Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr Arg 
65                  70                  75                  80  


Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Lys Tyr Leu Pro Glu Ala Tyr 
                85                  90                  95      


Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp Leu 
            100                 105                 110         


Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Ile Leu Arg Arg 
        115                 120                 125             


Thr Ser Ala Cys Ala Gly Gly Arg Trp Val Tyr Thr Glu Glu Tyr Val 
    130                 135                 140                 


Thr Val Pro Val Gly Cys Thr Cys Val Pro Glu Gln Glu Lys Glu Ala 
145                 150                 155                 160 


Asp Ala Val Asn Ser Ser Met Asp Lys Gln Gly Ala Arg Leu Leu Leu 
                165                 170                 175     


Gly Pro Gly Asp Lys Pro Gly Arg Pro 
            180                 185 


<210>  145
<211>  187
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-17D protein.


<400>  145

Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys 
1               5                   10                  15      


Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala 
            20                  25                  30          


Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg 
        35                  40                  45              


Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp 
    50                  55                  60                  


Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala 
65                  70                  75                  80  


Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu 
                85                  90                  95      


Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu 
            100                 105                 110         


Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu 
        115                 120                 125             


Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala 
    130                 135                 140                 


Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys 
145                 150                 155                 160 


Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu 
                165                 170                 175     


Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
            180                 185         


<210>  146
<211>  129
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-17F protein.


<400>  146

Arg Lys His Leu Lys Ala Gly Glu Thr Ala Leu Cys Pro Pro Leu Glu 
1               5                   10                  15      


Asp Asn Ser Val Arg Val Asp Ile Arg Ile Leu Arg Gln Asn Arg Gly 
            20                  25                  30          


Ile Ser Ile Ser Asn Asp Phe Gln Asn Arg Ser Ser Ser Pro Trp Asp 
        35                  40                  45              


Tyr Asn Ile Thr Arg Asp Pro His Arg Phe Pro Ser Glu Ile Ala Glu 
    50                  55                  60                  


Ala Gln Cys Arg His Ser Gly Cys Ile Asn Ala Glu Gly Gln Glu Asp 
65                  70                  75                  80  


Ser Ser Met Asn Ser Val Pro Ile Gln Gln Glu Phe Leu Val Leu Arg 
                85                  90                  95      


Arg Glu Pro Gln Gly Cys Ser Arg Ser Phe Arg Leu Glu Lys Val Leu 
            100                 105                 110         


Val Thr Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg Tyr Val Arg 
        115                 120                 125             


Ala 
    


<210>  147
<211>  130
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-17F protein.


<400>  147

Arg Lys Asn Pro Lys Ala Gly Asp Thr Ala Leu Cys Pro Pro Leu Glu 
1               5                   10                  15      


Asp Asn Ser Val Arg Val Asp Ile Arg Ile Leu Arg Gln Asn Gln Gly 
            20                  25                  30          


Gly Ile Ser Ile Ser Asn Asp Phe Gln Asn Arg Ser Ser Ser Pro Trp 
        35                  40                  45              


Asp Tyr Asn Val Thr Arg Asp Pro Asn Arg Phe Pro Ser Glu Ile Val 
    50                  55                  60                  


Glu Ala Gln Cys Arg His Ser Gly Cys Ile Asn Ala Glu Gly Gln Glu 
65                  70                  75                  80  


Asp Ser Ser Met Asn Ser Val Pro Ile Gln Gln Glu Phe Leu Val Leu 
                85                  90                  95      


Arg Arg Glu Pro Gln Gly Cys Ser Arg Thr Phe Arg Leu Glu Lys Val 
            100                 105                 110         


Arg Val Thr Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg Tyr Val 
        115                 120                 125             


Arg Ala 
    130 


<210>  148
<211>  133
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-17F protein.


<400>  148

Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val Gln 
    130             


<210>  149
<211>  157
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-18 protein.


<400>  149

Tyr Phe Gly Lys Leu Glu Pro Lys Leu Ser Ile Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Val Asn Glu Gly Asn Gln Pro Val Phe Glu Asp 
            20                  25                  30          


Met Pro Asp Ser Asp Cys Thr Asp Asn Ala Pro His Thr Ile Phe Ile 
        35                  40                  45              


Ile Tyr Met Tyr Lys Asp Ser Leu Thr Arg Gly Leu Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Tyr Lys Thr Met Ser Thr Leu Ser Cys Lys Asn Lys Thr 
65                  70                  75                  80  


Ile Ser Phe Gln Lys Met Ser Pro Pro Asp Ser Ile Asn Asp Glu Gly 
                85                  90                  95      


Asn Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asp Lys 
            100                 105                 110         


Ile Gln Phe Glu Ser Ser Leu Tyr Lys Gly His Phe Leu Ala Cys Lys 
        115                 120                 125             


Lys Glu Asn Asp Leu Phe Lys Leu Ile Leu Lys Asp Lys Asp Glu Asn 
    130                 135                 140                 


Gly Asp Lys Ser Ile Met Phe Thr Val Gln Asn Lys Ser 
145                 150                 155         


<210>  150
<211>  157
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-18 protein.


<400>  150

Tyr Phe Gly Lys Leu Glu His Lys Leu Ser Ile Leu Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asn Gln Gly Asp Gln Pro Val Phe Glu Asp 
            20                  25                  30          


Met Pro Asp Ser Asp Cys Thr Asp Asn Ala Pro Arg Thr Glu Phe Ile 
        35                  40                  45              


Ile Tyr Met Tyr Lys Asp Ser Leu Thr Arg Gly Leu Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Asn Tyr Lys Thr Met Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Ser Pro Pro Glu Ser Ile Asn Asp Glu Gly 
                85                  90                  95      


Asn Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asp Lys 
            100                 105                 110         


Ile Gln Phe Glu Ser Ser Leu Tyr Lys Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Lys Asp Leu Phe Lys Leu Ile Leu Lys Lys Lys Asp Glu Asn 
    130                 135                 140                 


Gly Asp Lys Ser Ile Met Phe Thr Val Gln Asn Lys Asn 
145                 150                 155         


<210>  151
<211>  157
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-18 protein.


<400>  151

Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210>  152
<211>  153
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-19 protein.


<400>  152

Leu Arg Arg Cys Leu Ile Ser Thr Asp Met His His Ile Glu Glu Ser 
1               5                   10                  15      


Phe Gln Glu Ile Lys Arg Ala Ile Gln Ala Lys Asp Thr Phe Pro Asn 
            20                  25                  30          


Val Thr Ile Leu Ser Thr Leu Glu Thr Leu Gln Ile Ile Lys Pro Leu 
        35                  40                  45              


Asp Val Cys Cys Val Thr Lys Asn Leu Leu Ala Phe Tyr Val Asp Arg 
    50                  55                  60                  


Val Phe Lys Asp His Gln Glu Pro Asn Pro Lys Ile Leu Arg Lys Ile 
65                  70                  75                  80  


Ser Ser Ile Ala Asn Ser Phe Leu Tyr Met Gln Lys Thr Leu Arg Gln 
                85                  90                  95      


Cys Gln Glu Gln Arg Gln Cys His Cys Arg Gln Glu Ala Thr Asn Ala 
            100                 105                 110         


Thr Arg Val Ile His Asp Asn Tyr Asp Gln Leu Glu Val His Ala Ala 
        115                 120                 125             


Ala Ile Lys Ser Leu Gly Glu Leu Asp Val Phe Leu Ala Trp Ile Asn 
    130                 135                 140                 


Lys Asn His Glu Val Met Phe Ser Ala 
145                 150             


<210>  153
<211>  152
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-20 protein.


<400>  153

Leu Lys Thr Leu Asn Leu Gly Ser Cys Val Ile Ala Thr Asn Leu Gln 
1               5                   10                  15      


Glu Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val Gln Ala Lys 
            20                  25                  30          


Asp Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu Ser Leu Gln 
        35                  40                  45              


Asp Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His Leu Leu Arg 
    50                  55                  60                  


Leu Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro Asp His Tyr 
65                  70                  75                  80  


Thr Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu Thr Ile Lys 
                85                  90                  95      


Lys Asp Leu Arg Leu Cys His Ala His Met Thr Cys His Cys Gly Glu 
            100                 105                 110         


Glu Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe Glu Lys Leu 
        115                 120                 125             


Glu Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu Asp Ile Leu 
    130                 135                 140                 


Leu Gln Trp Met Glu Glu Thr Glu 
145                 150         


<210>  154
<211>  129
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-21 protein.


<400>  154

His Lys Ser Ser Phe Gln Glu Gln Asp Leu Leu Leu Ile Arg Met Arg 
1               5                   10                  15      


Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu 
            20                  25                  30          


Asp Pro Glu Ser Leu Pro Ala Pro Glu Asp Val Lys Arg His Cys Glu 
        35                  40                  45              


Arg Ser Ala Phe Ser Cys Phe Gln Lys Val Gln Leu Lys Ala Ala Asn 
    50                  55                  60                  


Thr Gly Gly Asn Glu Gln Ile Ile Asn Val Leu Thr Lys Gln Leu Lys 
65                  70                  75                  80  


Arg Lys Leu Pro Pro Thr Asn Ala Gly Arg Arg Gln Lys His Arg Pro 
                85                  90                  95      


Ala Cys Pro Ser Cys Asp Ser Tyr Glu Lys Ala Pro Pro Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Ser Leu Ile Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Ser 
    


<210>  155
<211>  138
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-21 protein.


<400>  155

His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg 
1               5                   10                  15      


Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu 
            20                  25                  30          


Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu 
        35                  40                  45              


Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn 
    50                  55                  60                  


Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys 
65                  70                  75                  80  


Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu 
                85                  90                  95      


Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
    130                 135             


<210>  156
<211>  146
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-22 protein.


<400>  156

Leu Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Asn Met Gly Glu Arg Cys Tyr Leu Met Lys Glu Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Leu Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Lys Leu 
                85                  90                  95      


Ser Gln Cys His Ile Glu Asn Asp Asp Gln His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Gln Lys Leu Gly Glu Asn Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ala Leu Arg Asn Ala 
    130                 135                 140                 


Cys Val 
145     


<210>  157
<211>  146
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-22 protein.


<400>  157

Val Pro Ile Ser Ser His Cys Arg Leu Asp Gly Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe Tyr 
        35                  40                  45              


Glu Val Asn Met Gly Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Leu Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Lys Leu 
                85                  90                  95      


Ser Gln Cys His Ile Asp Ser Asp Asp Gln His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Asn Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Asn Gly Glu Ile 
        115                 120                 125             


Lys Val Ile Gly Glu Leu Asp Leu Leu Phe Met Ala Leu Arg Asn Ala 
    130                 135                 140                 


Cys Asn 
145     


<210>  158
<211>  146
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-22 protein.


<400>  158

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  159
<211>  102
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-24 protein.


<400>  159

Gln Glu Phe Arg Phe Gly Pro Cys Arg Val Gln Gly Val Ala Leu Arg 
1               5                   10                  15      


Glu Leu Arg Glu Ala Phe Trp Thr Val Lys Asp Thr Val Gln Ala Lys 
            20                  25                  30          


Asp Asn Ile Thr Ser Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asp 
        35                  40                  45              


Val Ser Gln Glu Asp Glu Met Phe Ser Ile Ser Glu Ser Ala Arg Arg 
    50                  55                  60                  


Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met 
                85                  90                  95      


Glu Lys Phe Tyr Glu Phe 
            100         


<210>  160
<211>  155
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-24 Family Protein.


<400>  160

Gln Glu Phe Arg Phe Gly Pro Cys Arg Val Gln Gly Val Ala Leu Arg 
1               5                   10                  15      


Glu Leu Arg Glu Ala Phe Trp Thr Val Lys Asp Thr Val Gln Ala Lys 
            20                  25                  30          


Asp Asn Ile Thr Ser Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asp 
        35                  40                  45              


Val Ser Asp Ala Glu Ser Cys Tyr Leu Ile Arg Ala Leu Leu Lys Phe 
    50                  55                  60                  


Tyr Leu Asn Thr Val Phe Lys Asn Tyr Leu Asp Glu Ala Ala Asp Val 
65                  70                  75                  80  


Arg Ile Arg Arg Ser Phe Ser Thr Leu Ala Asn Asn Phe Phe Val Ile 
                85                  90                  95      


Ala Ser Lys Leu Gln Pro Ser Gln Glu Asp Glu Met Phe Ser Ile Ser 
            100                 105                 110         


Glu Ser Ala Arg Arg Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln 
        115                 120                 125             


Leu Asp Ile Gln Ala Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile 
    130                 135                 140                 


Leu Leu Thr Trp Met Glu Lys Phe Tyr Glu Phe 
145                 150                 155 


<210>  161
<211>  102
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-24 protein.


<400>  161

Gln Glu Phe Gln Phe Gly Pro Cys Arg Val Glu Gly Val Val Leu Gln 
1               5                   10                  15      


Glu Leu Trp Glu Ala Phe Trp Ala Met Lys Asp Ile Val Gln Ala Lys 
            20                  25                  30          


Asp Asn Ile Thr Asn Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asn 
        35                  40                  45              


Val Ser Gln Glu Asn Glu Met Phe Ser Val Ser Asp Ser Ala Arg Arg 
    50                  55                  60                  


Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Glu Ala 
65                  70                  75                  80  


Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met 
                85                  90                  95      


Glu Lys Phe Tyr Gln Leu 
            100         


<210>  162
<211>  155
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-24 Family Protein.


<400>  162

Gln Glu Phe Gln Phe Gly Pro Cys Arg Val Glu Gly Val Val Leu Gln 
1               5                   10                  15      


Glu Leu Trp Glu Ala Phe Trp Ala Met Lys Asp Ile Val Gln Ala Lys 
            20                  25                  30          


Asp Asn Ile Thr Asn Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asn 
        35                  40                  45              


Val Ser Asn Ala Glu Ser Cys Tyr Leu Ile Arg Ala Leu Leu Lys Phe 
    50                  55                  60                  


Tyr Leu Asn Thr Val Phe Lys Asn Tyr Gln Asp Lys Ala Ala Asp Phe 
65                  70                  75                  80  


Arg Val Arg Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe Val Val Ile 
                85                  90                  95      


Val Ser Lys Leu Gln Pro Ser Gln Glu Asn Glu Met Phe Ser Val Ser 
            100                 105                 110         


Asp Ser Ala Arg Arg Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln 
        115                 120                 125             


Leu Asp Ile Glu Ala Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile 
    130                 135                 140                 


Leu Leu Thr Trp Met Glu Lys Phe Tyr Gln Leu 
145                 150                 155 


<210>  163
<211>  155
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-24 protein.


<400>  163

Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly Val Val Pro Gln 
1               5                   10                  15      


Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr Met Gln Ala Gln 
            20                  25                  30          


Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu Val Leu Gln Asn 
        35                  40                  45              


Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr Leu Leu Glu Phe 
    50                  55                  60                  


Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg Thr Val Glu Val 
65                  70                  75                  80  


Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe Val Leu Ile 
                85                  90                  95      


Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met Phe Ser Ile Arg 
            100                 105                 110         


Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala Phe Lys Gln 
        115                 120                 125             


Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu Val Asp Ile 
    130                 135                 140                 


Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
145                 150                 155 


<210>  164
<211>  145
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-25 protein.


<400>  164

Cys Thr His Trp Pro Asn Cys Cys Pro Ser Lys Arg Gln Asp Pro Thr 
1               5                   10                  15      


His Glu Trp Leu Lys Arg Asp Thr Val Leu Lys Phe Pro Gly Glu Thr 
            20                  25                  30          


Thr Ser Leu Thr His His Pro Glu Ser Cys Lys Ala Ser Glu Asp Gly 
        35                  40                  45              


Pro Leu Asn Ser Arg Ser Ile Ser Pro Trp Lys Tyr Glu Leu Asp Arg 
    50                  55                  60                  


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
65                  70                  75                  80  


Gln His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Leu Gly 
                85                  90                  95      


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
            100                 105                 110         


Cys Pro Gly Glu Gln Gly Ala Pro Asp Gly Tyr Cys Leu Glu Gln Arg 
        115                 120                 125             


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
    130                 135                 140                 


Ala 
145 


<210>  165
<211>  145
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-25 protein.


<400>  165

Leu Ser His Trp Ser Ser Cys Cys Pro Ser Lys Gly Gln Asn Pro Thr 
1               5                   10                  15      


His Glu Trp Leu Thr Glu Asn Thr Val Leu Met Thr Pro Pro Glu Ser 
            20                  25                  30          


Ala Ser Leu Ile His Ser Leu Glu Ser Cys Arg Ala Ser Glu Asp Gly 
        35                  40                  45              


Pro Leu Asn Ser Arg Ser Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
    50                  55                  60                  


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
65                  70                  75                  80  


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Leu Gly 
                85                  90                  95      


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
            100                 105                 110         


Cys Pro Gly Glu Gln Gly Thr Arg Asp Gly Tyr Cys Leu Glu Gln Arg 
        115                 120                 125             


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
    130                 135                 140                 


Ala 
145 


<210>  166
<211>  145
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-25 protein.


<400>  166

Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
1               5                   10                  15      


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
            20                  25                  30          


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
        35                  40                  45              


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
    50                  55                  60                  


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
65                  70                  75                  80  


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
                85                  90                  95      


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
            100                 105                 110         


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
        115                 120                 125             


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
    130                 135                 140                 


Gly 
145 


<210>  167
<211>  150
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-26 family protein.


<400>  167

Lys His Lys Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Gln Ala Val Asp Thr Leu Tyr Val Lys Ala Ala Trp Leu Lys 
            20                  25                  30          


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Arg Lys 
        35                  40                  45              


Lys Thr Lys Asn Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu 
    50                  55                  60                  


Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln Leu Gln Leu Lys Ile 
65                  70                  75                  80  


Cys Arg Glu Ile Arg Phe Val Glu Glu Leu His Ser Leu Arg Gln Gln 
                85                  90                  95      


Leu Ser Arg Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Thr 
            100                 105                 110         


Ile Thr Arg Met Lys Ser Thr Phe Tyr Gly Leu Gly Asn Lys Gly Ile 
        115                 120                 125             


Tyr Lys Ala Ile Ser Glu Leu Asn Ile Leu Leu Ser Trp Ile Lys Gln 
    130                 135                 140                 


Phe Leu Glu Ser Ile Lys 
145                 150 


<210>  168
<211>  127
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-26 protein.


<400>  168

Lys His Lys Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Gln Ala Val Asp Arg Leu Tyr Val Lys Ala Ala Trp Leu Lys 
            20                  25                  30          


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys 
        35                  40                  45              


Lys Thr Lys Lys Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu 
    50                  55                  60                  


Leu Ser Phe Phe Met Asp Asp Val Phe Gly Gln Leu Gln Leu Gln Val 
65                  70                  75                  80  


Cys Lys Glu Arg His Phe Val Glu Glu Phe His Ser Leu Arg Gln Gln 
                85                  90                  95      


Leu Ser Arg Cys Val Leu Ser Trp Val Arg Lys Thr Ser Leu Ile Lys 
            100                 105                 110         


Ser Pro Val Ser Gly Ala Cys Thr Leu Leu Thr Gly Arg Glu Met 
        115                 120                 125         


<210>  169
<211>  150
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-26 family protein.


<400>  169

Lys His Lys Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Gln Ala Val Asp Arg Leu Tyr Val Lys Ala Ala Trp Leu Lys 
            20                  25                  30          


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys 
        35                  40                  45              


Lys Thr Lys Lys Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu 
    50                  55                  60                  


Leu Ser Phe Phe Met Asp Asp Val Phe Gly Gln Leu Gln Leu Gln Val 
65                  70                  75                  80  


Cys Lys Glu Arg His Phe Val Glu Glu Phe His Ser Leu Arg Gln Gln 
                85                  90                  95      


Leu Ser Arg Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Thr 
            100                 105                 110         


Ile Thr Arg Met Lys Arg Thr Phe Tyr Gly Ile Gly Asn Lys Gly Ile 
        115                 120                 125             


Tyr Lys Ala Val Ser Glu Leu Asp Ile Leu Leu Ser Trp Ile Lys Gln 
    130                 135                 140                 


Phe Leu Glu Ser Ile Lys 
145                 150 


<210>  170
<211>  150
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-26 protein.


<400>  170

Lys His Lys Gln Ser Ser Phe Thr Lys Ser Cys Tyr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Gln Ala Val Asp Ala Leu Tyr Ile Lys Ala Ala Trp Leu Lys 
            20                  25                  30          


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys 
        35                  40                  45              


Lys Thr Lys Lys Gln Phe Met Lys Asn Cys Gln Phe Gln Glu Gln Leu 
    50                  55                  60                  


Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln Leu Gln Leu Gln Gly 
65                  70                  75                  80  


Cys Lys Lys Ile Arg Phe Val Glu Asp Phe His Ser Leu Arg Gln Lys 
                85                  90                  95      


Leu Ser His Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Ser 
            100                 105                 110         


Ile Thr Arg Met Lys Arg Ile Phe Tyr Arg Ile Gly Asn Lys Gly Ile 
        115                 120                 125             


Tyr Lys Ala Ile Ser Glu Leu Asp Ile Leu Leu Ser Trp Ile Lys Lys 
    130                 135                 140                 


Leu Leu Glu Ser Ser Gln 
145                 150 


<210>  171
<211>  204
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-27 protein.


<400>  171

Phe Pro Arg Pro Pro Gly Arg Ser Pro Leu Ser Leu Gln Glu Leu Arg 
1               5                   10                  15      


Arg Glu Phe Lys Val Ser Leu Gln Leu Ala Lys Lys Leu Phe Ser Glu 
            20                  25                  30          


Val Arg Ile Gln Ala His His Phe Ala Glu Ser Gln Leu Pro Gly Val 
        35                  40                  45              


Ser Leu Asp Leu Leu Pro Leu Gly Asp Gln Leu Pro Asn Val Ser Leu 
    50                  55                  60                  


Pro Phe Gln Ala Trp His Ser Leu Ser Asp Pro Glu Arg Leu Cys Phe 
65                  70                  75                  80  


Leu Ser Met Met Leu His Pro Phe His Ala Leu Leu Glu Ser Leu Gly 
                85                  90                  95      


Ser Gln Gly Gly Trp Thr Ser Ser Glu Lys Met His Leu Trp Thr Met 
            100                 105                 110         


Arg Leu Asp Leu Arg Asp Leu Gln Arg His Leu Arg Phe Gln Val Glu 
        115                 120                 125             


Tyr Pro Pro Thr Cys Ser Thr Pro Arg Asp Gln His Thr Lys Leu Lys 
    130                 135                 140                 


Leu Ile Gly Ser Leu Leu Lys Thr Ser Pro Ala Gln Arg Leu Gly Lys 
145                 150                 155                 160 


Phe Gly Gly Arg Cys Ser Arg Ser Ser Val Cys Val Cys Val Cys Val 
                165                 170                 175     


Cys Val Cys Val Cys Val Cys Pro Arg Pro Arg Leu Cys Ser Leu Asn 
            180                 185                 190         


Leu Cys Leu Pro Met Glu Ser Trp Ser Glu Gln Leu 
        195                 200                 


<210>  172
<211>  208
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-27 protein.


<400>  172

Phe Pro Arg Pro Pro Gly Arg Pro Pro Leu Ser Leu Gln Glu Leu Arg 
1               5                   10                  15      


Arg Glu Phe Lys Val Ser Leu His Leu Ala Arg Lys Leu Phe Ser Glu 
            20                  25                  30          


Val Arg Thr Gln Ala His Arg Phe Ala Glu Ser His Leu Pro Gly Val 
        35                  40                  45              


Ser Leu Asp Leu Leu Pro Leu Gly Asp Arg Leu Pro Asn Val Ser Leu 
    50                  55                  60                  


Thr Phe Gln Ala Trp His Ser Leu Ser Asp Pro Glu Arg Leu Cys Phe 
65                  70                  75                  80  


Leu Phe Met Thr Leu Arg Pro Phe His Ala Leu Leu Gly Ser Leu Gly 
                85                  90                  95      


Ser Gln Gly Gly Trp Thr Ser Ser Glu Lys Ile Asp Leu Trp Thr Met 
            100                 105                 110         


Arg Leu Asp Leu Arg Asp Leu Gln Arg His Leu His Phe Gln Val Leu 
        115                 120                 125             


Ala Ala Gly Leu Asn Leu Pro Glu Glu Glu Asp Asp Glu Glu Arg Lys 
    130                 135                 140                 


Glu Pro Leu Pro Gly Ala Pro Ser Gly Leu Ser Arg Val Ser Gly Gln 
145                 150                 155                 160 


Pro Ser Trp Pro Gln Leu Leu Tyr Thr Tyr Gln Leu Leu His Ser Leu 
                165                 170                 175     


Glu Leu Val Leu Ala Arg Ala Val Arg Asp Leu Leu Leu Leu Ser Gln 
            180                 185                 190         


Ala Gly Asn Pro Ala Pro Ala Ser Gly Ser Ser Phe Gly Ser Trp Pro 
        195                 200                 205             


<210>  173
<211>  171
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-29 protein.


<400>  173

Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Arg Arg Gly Cys His 
1               5                   10                  15      


Met Asp Arg Phe Gln Ser Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys 
            20                  25                  30          


Lys Thr Lys Asp Ala Leu Glu Glu Ser Leu Ser Trp Lys Asn Trp Ser 
        35                  40                  45              


Cys Ser Ser Arg Leu Phe Pro Arg Ser Arg Asp Leu Arg Leu Leu Gln 
    50                  55                  60                  


Ala Trp Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Asp Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Glu Asn Met Thr Asp Ser Ser Leu Gly Val Thr Leu Asp 
                85                  90                  95      


Gln Pro Leu Arg Thr Leu His His Ile His Ser Glu Leu Gln Ala Cys 
            100                 105                 110         


Val Pro Ala Gln Pro Thr Ala Asp Pro Arg Pro His Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Lys Ala Pro Lys Glu Ser Gln Gly Cys 
    130                 135                 140                 


Leu Glu Ala Ser Ile Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp 
145                 150                 155                 160 


Leu Lys Cys Val Ala Ser Arg Asp Leu Cys Val 
                165                 170     


<210>  174
<211>  170
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Dog IL-29 protein.


<400>  174

Gly Pro Val Pro Thr Ser Lys Pro Thr Met Ala Trp Arg Gly Cys Asp 
1               5                   10                  15      


Ile Gly Arg Phe Lys Ser Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys 
            20                  25                  30          


Lys Ala Lys Asp Ala Leu Glu Tyr Ser Leu Lys Asn Trp Ser Cys Asn 
        35                  40                  45              


Ser Arg Leu Phe Pro Arg Asn Arg Asp Leu Arg Gln Leu Gln Val Trp 
    50                  55                  60                  


Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val 
65                  70                  75                  80  


Leu Glu Thr Met Ala Asp Arg Ser Leu Gly Asp Ile Leu Asp Gln Pro 
                85                  90                  95      


Leu His Thr Leu Arg His Ile His Ser Gln Leu Gln Ala Cys Val Ser 
            100                 105                 110         


Ala Gln Pro Pro Ala Gly Pro Gln Pro Arg Gly Arg Leu His Pro Trp 
        115                 120                 125             


Leu His Arg Leu His Glu Ala Ser Lys Lys Glu Ser Gln Gly Cys Leu 
    130                 135                 140                 


Glu Ala Ser Val Leu Phe Asn Leu Phe Arg Leu Leu Lys Lys Asp Leu 
145                 150                 155                 160 


Glu Cys Val Ala Val Gly Asp Leu Cys Val 
                165                 170 


<210>  175
<211>  171
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-29 protein.


<400>  175

Gly Pro Val Pro Thr Ser Arg Pro Pro Pro Thr Arg Arg Gly Cys His 
1               5                   10                  15      


Val Gly Lys Phe Pro Ser Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys 
            20                  25                  30          


Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Pro Leu Lys Asn Trp Ser 
        35                  40                  45              


Cys Gly Ser Arg Leu Phe Pro Arg Thr Arg Asp Leu Ile Arg Leu Gln 
    50                  55                  60                  


Ala Trp Glu Arg Pro Ala Ala Leu Glu Ala Glu Leu Asp Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Gly Asn Met Thr Asp Ser Ser Leu Gly Val Val Leu Asp 
                85                  90                  95      


Gln Pro Leu Arg Val Val Arg His Ile His Ser Glu Leu Gln Ala Cys 
            100                 105                 110         


Val Arg Ala Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Arg Pro Pro Glu Glu Ser Gln Gly Cys 
    130                 135                 140                 


Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp 
145                 150                 155                 160 


Leu Lys Cys Val Thr Gly Gly Asp Leu Cys Val 
                165                 170     


<210>  176
<211>  171
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-29, IFN-lambda1 protein.


<400>  176

Gly Pro Val Pro Thr Ser Arg Pro Pro Pro Thr Arg Arg Gly Cys His 
1               5                   10                  15      


Val Gly Lys Phe Pro Ser Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys 
            20                  25                  30          


Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Pro Leu Lys Asn Trp Ser 
        35                  40                  45              


Cys Gly Ser Arg Leu Phe Pro Arg Thr Arg Asp Leu Ile Arg Leu Gln 
    50                  55                  60                  


Ala Trp Glu Arg Pro Ala Ala Leu Glu Ala Glu Leu Asp Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Gly Asn Met Thr Asp Ser Ser Leu Gly Val Val Leu Asp 
                85                  90                  95      


Gln Pro Leu Arg Val Leu Arg His Ile His Ser Glu Leu Gln Ala Cys 
            100                 105                 110         


Val Arg Ala Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Arg Ala Pro Glu Glu Ser Gln Gly Cys 
    130                 135                 140                 


Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp 
145                 150                 155                 160 


Leu Lys Cys Val Thr Gly Gly Asp Leu Cys Val 
                165                 170     


<210>  177
<211>  181
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-29, IFN-lambda1 protein.


<400>  177

Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys Gly Cys His 
1               5                   10                  15      


Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys 
            20                  25                  30          


Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser 
        35                  40                  45              


Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln 
    50                  55                  60                  


Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp 
                85                  90                  95      


Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Cys 
            100                 105                 110         


Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly 
    130                 135                 140                 


Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg 
145                 150                 155                 160 


Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg Thr Ser Thr 
                165                 170                 175     


His Pro Glu Ser Thr 
            180     


<210>  178
<211>  160
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Cat IL-32 protein.


<400>  178

Met Arg His Gln Met His Gln Leu Val Asp Ile Phe Cys Asp Arg Thr 
1               5                   10                  15      


Gln His Gln Ser Arg Gly Ala Pro Gln Gln Arg Leu Arg Leu Gly Glu 
            20                  25                  30          


Val Glu Asp Gly Phe Asn Glu Ile Met Leu Glu Ala Val Asp Leu His 
        35                  40                  45              


His His Gln Asn Asp Asp Glu Glu Ser Ser Pro Leu Leu Pro Glu Val 
    50                  55                  60                  


Arg Gln Glu Leu Arg Ser Arg Val Leu Arg Ser Ser Val Leu Asp Leu 
65                  70                  75                  80  


Glu Glu Lys Glu His Pro Val Val Gln Lys Thr Glu Glu Ser Phe Cys 
                85                  90                  95      


Asp Arg Ala Leu Arg Leu Phe Arg Arg Leu Leu Tyr Gln Leu Gln Leu 
            100                 105                 110         


Lys Trp Gln Ala Ala Leu Ala Trp Leu Arg Glu Lys Val Ala Ala Gly 
        115                 120                 125             


Phe Gln Ala Phe Cys Asp Ala Val Glu Ala Ile Cys Ser Ala Phe Asn 
    130                 135                 140                 


Ser Phe Cys Thr Ser Val Ala Gln Val Phe Arg Ser Ala Val Gln Ala 
145                 150                 155                 160 


<210>  179
<211>  214
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine IL-34 protein.


<400>  179

Asn Glu Gly Leu Glu Pro Trp Pro Leu Thr Arg Ser Asp Glu Cys Ala 
1               5                   10                  15      


Ile Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln 
            20                  25                  30          


Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Val Ser Val Pro Tyr 
        35                  40                  45              


Glu Gly Val Leu Arg Thr Ala Asn Val Thr Arg Leu Gln Arg Ala Gln 
    50                  55                  60                  


Val Ser Gln Gln Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser 
65                  70                  75                  80  


Ala Thr Glu Trp Val Gln Glu Val Leu Leu Glu Gly His Pro Ser Trp 
                85                  90                  95      


Lys Tyr Leu Glu Glu Val His Thr Leu Leu Leu Asp Val Lys Gln Gly 
            100                 105                 110         


Leu Gly Gly Val Glu Val Ser Pro Gln Val Glu Ala Val Leu Asn Leu 
        115                 120                 125             


Leu Ser Ala Pro Gly Ser Leu Lys Leu Val Arg Pro Lys Ala Leu Leu 
    130                 135                 140                 


Asp Asn Cys Phe Arg Val Met Gln Leu Leu Tyr Cys Pro Cys Cys Lys 
145                 150                 155                 160 


Glu Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Ala Pro Gln Pro Gln 
                165                 170                 175     


Pro Arg Ser Pro Ala Ser Ala Gln Cys Glu Ala Ala Gln Leu Tyr Pro 
            180                 185                 190         


Leu Pro Gln Pro Pro Ser Thr Ser Leu Pro Arg Val Leu Gly Pro Ser 
        195                 200                 205             


Ala Gly Pro Pro Thr Gln 
    210                 


<210>  180
<211>  153
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-36-alpha protein.


<400>  180

Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln Asp Ile Asn His Arg 
1               5                   10                  15      


Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala Val Pro Arg Lys Asp 
            20                  25                  30          


Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser Cys Arg His Val Glu 
        35                  40                  45              


Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu Gly Leu Asn Gly 
    50                  55                  60                  


Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly Asp Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly Arg Asn Ser Thr 
            100                 105                 110         


Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala Val Ser Ser Glu 
        115                 120                 125             


Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Lys Ala Asn Thr 
    130                 135                 140                 


Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150             


<210>  181
<211>  160
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-36-beta protein.


<400>  181

Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp Ser Arg Gln Met 
1               5                   10                  15      


Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala Pro Leu Ser Arg 
            20                  25                  30          


Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys Arg Asp Thr Glu 
        35                  40                  45              


Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu Gly Ile Lys Gly 
    50                  55                  60                  


Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly Lys Asp Thr Cys 
                85                  90                  95      


Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu Asp Val Arg Glu 
            100                 105                 110         


Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile Gly Val Gly Arg 
        115                 120                 125             


Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu Arg Lys Lys Asp 
    130                 135                 140                 


Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met Pro Gly Arg Met 
145                 150                 155                 160 


<210>  182
<211>  152
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-36-gamma protein.


<400>  182

Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln Gln 
1               5                   10                  15      


Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser Asp 
            20                  25                  30          


Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro Glu 
        35                  40                  45              


Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln Asn 
    50                  55                  60                  


Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser Thr 
            100                 105                 110         


Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys Arg 
        115                 120                 125             


Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn Thr 
    130                 135                 140                 


Ala Phe Glu Leu Asn Ile Asn Asp 
145                 150         


<210>  183
<211>  193
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Canis IL-37 protein.


<400>  183

Met Ser Phe Leu Glu Asp Ser Gly Val Lys Met Glu Ser Glu Asp Trp 
1               5                   10                  15      


Glu Arg Asp Glu Pro His Gly Cys Ser Glu Gly Pro Lys Val Lys Val 
            20                  25                  30          


Ser Tyr Pro Glu Lys Phe Ser Ile His Asp Arg Asp His Lys Val Leu 
        35                  40                  45              


Val Leu Asp Cys Asp Thr Leu Arg Ala Val Pro Phe Lys Thr Tyr Ile 
    50                  55                  60                  


Arg Pro Glu Met Phe Phe Val Leu Ala Ser Ser Leu Ser Ser Ala Ser 
65                  70                  75                  80  


Lys Glu Lys Gly Ser Pro Ile Leu Leu Ala Val Cys Lys Gly Glu Leu 
                85                  90                  95      


Cys Leu Cys Cys Glu Lys Asp Arg Arg Gln Ser Gln Pro Ser Leu Gln 
            100                 105                 110         


Leu Lys Lys Lys Lys Leu Thr Asn Leu Ala Ala Gln Lys Glu Ser Ala 
        115                 120                 125             


Arg Gln Pro Phe Ile Phe Tyr Arg Thr Lys Val Gly Ser Gln Asn Arg 
    130                 135                 140                 


Leu Glu Ser Ala Ala His Pro Gly Trp Phe Ile Cys Thr Ser Arg Asn 
145                 150                 155                 160 


Ser Gly Glu Pro Val Gly Val Thr Asn Val Leu Gly Lys Arg Lys His 
                165                 170                 175     


Thr Glu Phe Ser Phe His Arg Ala Glu Thr Ser Pro Ser Glu Val Ser 
            180                 185                 190         


Gly 
    


<210>  184
<211>  152
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-38 protein.


<400>  184

Met Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp 
1               5                   10                  15      


Gln Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro 
            20                  25                  30          


Val Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile Leu Pro Asn Arg 
        35                  40                  45              


Gly Leu Ala Arg Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly 
    50                  55                  60                  


Ser Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln 
65                  70                  75                  80  


Leu Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala 
                85                  90                  95      


Thr Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu 
            100                 105                 110         


Glu Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro 
        115                 120                 125             


Gln Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Glu Gln Ser Trp 
145                 150         


<210>  185
<211>  245
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-40 protein.


<400>  185

Arg Glu Glu Glu Ile Thr Pro Val Val Ser Ile Ala Tyr Lys Val Leu 
1               5                   10                  15      


Glu Val Phe Pro Lys Gly Arg Trp Val Leu Ile Thr Cys Cys Ala Pro 
            20                  25                  30          


Gln Pro Pro Pro Pro Ile Thr Tyr Ser Leu Cys Gly Thr Lys Asn Ile 
        35                  40                  45              


Lys Val Ala Lys Lys Val Val Lys Thr His Glu Pro Ala Ser Phe Asn 
    50                  55                  60                  


Leu Asn Val Thr Leu Lys Ser Ser Pro Asp Leu Leu Thr Tyr Phe Cys 
65                  70                  75                  80  


Trp Ala Ser Ser Thr Ser Gly Ala His Val Asp Ser Ala Arg Leu Gln 
                85                  90                  95      


Met His Trp Glu Leu Trp Ser Lys Pro Val Ser Glu Leu Arg Ala Asn 
            100                 105                 110         


Phe Thr Leu Gln Asp Arg Gly Ala Gly Pro Arg Val Glu Met Ile Cys 
        115                 120                 125             


Gln Ala Ser Ser Gly Ser Pro Pro Ile Thr Asn Ser Leu Ile Gly Lys 
    130                 135                 140                 


Asp Gly Gln Val His Leu Gln Gln Arg Pro Cys His Arg Gln Pro Ala 
145                 150                 155                 160 


Asn Phe Ser Phe Leu Pro Ser Gln Thr Ser Asp Trp Phe Trp Cys Gln 
                165                 170                 175     


Ala Ala Asn Asn Ala Asn Val Gln His Ser Ala Leu Thr Val Val Pro 
            180                 185                 190         


Pro Gly Gly Asp Gln Lys Met Glu Asp Trp Gln Gly Pro Leu Glu Ser 
        195                 200                 205             


Pro Ile Leu Ala Leu Pro Leu Tyr Arg Ser Thr Arg Arg Leu Ser Glu 
    210                 215                 220                 


Glu Glu Phe Gly Gly Phe Arg Ile Gly Asn Gly Glu Val Arg Gly Arg 
225                 230                 235                 240 


Lys Ala Ala Ala Met 
                245 


<210>  186
<211>  247
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Canis IL-40 isoform X2 protein.


<400>  186

Met Arg Leu Leu Leu Leu Leu Cys Leu Ala Leu Leu Ala Thr Cys Ser 
1               5                   10                  15      


Phe Ser Leu Glu Gln Glu Val Glu Val Thr Pro Glu Thr Phe Ile Ala 
            20                  25                  30          


Tyr Lys Val Arg Glu Val Phe Pro Ser Ser Arg Arg Val Val Ile Thr 
        35                  40                  45              


Cys His Ser Pro Arg Ala Pro Pro Pro Ile Thr Tyr Ser Leu Trp Gly 
    50                  55                  60                  


Ser Gln Gly Val Glu Val Ala Lys Lys Val Val Lys Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Ser Phe Ser Ile Asn Ile Thr Leu Lys Ser Arg Pro Glu Leu Leu 
                85                  90                  95      


Thr Tyr Ser Cys Arg Ala Ala Ser Leu Arg Gly Glu His Ser Ala Ser 
            100                 105                 110         


Thr Lys Leu Gln Met Tyr Trp Glu Leu Trp Ala Lys Pro Met Ala Gln 
        115                 120                 125             


Pro Arg Ala Asn Phe Val Leu Leu Glu Arg Gly Ser Gly Pro Arg Val 
    130                 135                 140                 


Glu Ile Ser Cys Gln Val Ser Ser Gly Ser Pro Pro Ile Thr Tyr Ser 
145                 150                 155                 160 


Leu Val Arg Lys Asp Gly Tyr Val His Arg Gln Gln Arg Pro Thr Tyr 
                165                 170                 175     


Gly Gln Pro Ala Asn Phe Ser Phe Pro Leu Thr Arg Thr Ser Asn Trp 
            180                 185                 190         


Leu Arg Cys Gln Ala Ala Asn Asp Ile Ser Val Gln Ser Ser Pro Phe 
        195                 200                 205             


Arg Leu Val Pro Pro Gly Tyr Leu Pro Gln Gly Pro Val Leu Val Leu 
    210                 215                 220                 


Ala Gly Ser Leu Thr Ser Ile Ala Ala Val Thr Ser Trp Val Leu Gly 
225                 230                 235                 240 


Pro Ala Leu Trp Thr Arg Leu 
                245         


<210>  187
<211>  266
<212>  PRT
<213>  Homo sapiens

<220>
<223>  This is the amino acid sequence of Human IL-41, Meteorin-like protein.


<400>  187

Gln Tyr Ser Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr His 
1               5                   10                  15      


Glu Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ala Ala 
            20                  25                  30          


Gly Ala Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu 
        35                  40                  45              


Arg Pro Asn Thr Phe Ser Pro Ala Arg His Leu Thr Val Cys Ile Arg 
    50                  55                  60                  


Ser Phe Thr Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly 
65                  70                  75                  80  


Glu Leu Arg Leu Leu Val Pro Asp Gly Asp Gly Arg Pro Gly Arg Val 
                85                  90                  95      


Gln Cys Phe Gly Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro 
            100                 105                 110         


Gln Gln Asp Ile Gly Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Val 
        115                 120                 125             


Arg Arg His Arg Ala Ser Asp Leu His Glu Leu Ser Ala Pro Cys Arg 
    130                 135                 140                 


Pro Cys Ser Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe 
145                 150                 155                 160 


Ala Val Arg Gly Ser Ile Gln Gln Val Thr His Glu Pro Glu Arg Gln 
                165                 170                 175     


Asp Ser Ala Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser 
            180                 185                 190         


Arg Val Phe Glu Pro Val Pro Glu Gly Asp Gly His Trp Gln Gly Arg 
        195                 200                 205             


Val Arg Thr Leu Leu Glu Cys Gly Val Arg Pro Gly His Gly Asp Phe 
    210                 215                 220                 


Leu Phe Thr Gly His Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala 
225                 230                 235                 240 


Pro Arg Phe Lys Asp Phe Gln Arg Met Tyr Arg Asp Ala Gln Glu Arg 
                245                 250                 255     


Gly Leu Asn Pro Cys Glu Val Gly Thr Asp 
            260                 265     


<210>  188
<211>  296
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Canine IL-41, Meteorin-like protein.


<400>  188

Met Pro Pro Ser Val Met Ser Gln Met Cys Thr Phe Leu His Arg Gln 
1               5                   10                  15      


Gln Phe Cys Thr Asn Arg Ser Phe Phe Gly Phe Ala Val Ala Leu Glu 
            20                  25                  30          


His Arg Ser Glu Arg Phe Asp Gln Ile Phe Cys Gly Leu Thr His Glu 
        35                  40                  45              


Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ser Ala Gly 
    50                  55                  60                  


Ser Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Val Arg 
65                  70                  75                  80  


Pro Asn Thr Phe Pro Pro Ser Arg His Leu Thr Leu Cys Ile Lys Pro 
                85                  90                  95      


Leu Lys Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu 
            100                 105                 110         


Leu Lys Leu Leu Val Arg Asp Gly Asp Arg Gly Pro Gly Gln Val Arg 
        115                 120                 125             


Cys Phe Gly Phe Glu Gln Gly Gly Leu Phe Val Glu Ala Ala Pro Gln 
    130                 135                 140                 


Gln Asp Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Thr Ser 
145                 150                 155                 160 


Arg His Ala Glu Ser Asp Leu His Thr Leu Ser Ala Pro Cys Arg Pro 
                165                 170                 175     


Cys Ser Asp Ala Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe Val 
            180                 185                 190         


Val Arg Gly Ser Ile Gln Asn Val Thr His Val Pro Glu Gln Gln Glu 
        195                 200                 205             


Ser Ala Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser Arg 
    210                 215                 220                 


Val Phe Arg Pro Ala Pro Glu Gly Gly Gly Trp Arg Gly Arg Val Ala 
225                 230                 235                 240 


Thr Leu Leu Glu Cys Gly Val Arg Pro Gly Arg Gly Glu Phe Leu Phe 
                245                 250                 255     


Thr Gly His Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg 
            260                 265                 270         


Phe Lys Asp Phe Gln Arg Met Tyr Gln Asp Ala Glu Glu Arg Gly Leu 
        275                 280                 285             


Asn Pro Cys Glu Met Gly Lys Asp 
    290                 295     


<210>  189
<211>  266
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Feline IL-41, Meteorin-like protein.


<400>  189

Gln Tyr Ser Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr His 
1               5                   10                  15      


Glu Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ser Ala 
            20                  25                  30          


Gly Ser Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Val 
        35                  40                  45              


Arg Pro Asn Thr Phe Pro Pro Ser Arg Arg His Leu Thr Leu Cys Ile 
    50                  55                  60                  


Lys Pro Leu Arg Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr 
65                  70                  75                  80  


Gly Glu Leu Gln Leu Leu Val Arg Asp Gly Asp Arg Gly Pro Arg Gln 
                85                  90                  95      


Val His Cys Phe Gly Phe Glu Gln Arg Gly Leu Phe Val Glu Ala Thr 
            100                 105                 110         


Pro Gln Gln Asp Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu 
        115                 120                 125             


Thr Ser Arg His Ala Glu Ser Asp Leu Arg Ala Gln Ser Ala Pro Cys 
    130                 135                 140                 


Arg Pro Cys Ser Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser Asp 
145                 150                 155                 160 


Phe Val Val Arg Gly Ser Ile Gln Asp Val Thr His Glu Pro Glu Gln 
                165                 170                 175     


Gln Glu Ser Ala Ile His Leu His Val Asn Arg Leu Tyr Arg Gln Lys 
            180                 185                 190         


Ser Thr Val Phe Arg Pro Ala Pro Glu Gly Gly Gly Trp Arg Gly His 
        195                 200                 205             


Val Thr Thr Leu Leu Glu Cys Gly Val Arg Pro Gly Arg Gly Glu Phe 
    210                 215                 220                 


Leu Phe Thr Gly Pro Ile His Phe Gly Glu Ala His Leu Gly Cys Ala 
225                 230                 235                 240 


Pro Arg Phe Lys Asp Phe Gln Arg Met Tyr Lys Asp Ala Glu Glu Lys 
                245                 250                 255     


Gly Leu Asn Pro Cys Glu Met Gly Thr Glu 
            260                 265     


<210>  190
<211>  143
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine interferon-gamma protein.


<400>  190

Gln Gly Gln Phe Phe Arg Glu Ile Glu Asn Leu Lys Glu Tyr Phe Asn 
1               5                   10                  15      


Ala Ser Ser Pro Asp Val Ala Lys Gly Gly Pro Leu Phe Ser Glu Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Asp Glu Ser Asp Lys Lys Ile Ile Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Phe Lys Leu Phe Glu Asn Leu Lys Asp Asn Gln 
    50                  55                  60                  


Val Ile Gln Arg Ser Met Asp Ile Ile Lys Gln Asp Met Phe Gln Lys 
65                  70                  75                  80  


Phe Leu Asn Gly Ser Ser Glu Lys Leu Glu Asp Phe Lys Lys Leu Ile 
                85                  90                  95      


Gln Ile Pro Val Asp Asp Leu Gln Ile Gln Arg Lys Ala Ile Asn Glu 
            100                 105                 110         


Leu Ile Lys Val Met Asn Asp Leu Ser Pro Lys Ser Asn Leu Arg Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly Arg Arg Ala Ser Met 
    130                 135                 140             


<210>  191
<211>  143
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Canis interferon-gamma protein.


<400>  191

Gln Ala Met Phe Phe Lys Glu Ile Glu Asn Leu Lys Glu Tyr Phe Asn 
1               5                   10                  15      


Ala Ser Asn Pro Asp Val Ser Asp Gly Gly Ser Leu Phe Val Asp Ile 
            20                  25                  30          


Leu Lys Lys Trp Arg Glu Glu Ser Asp Lys Thr Ile Ile Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Leu Lys Leu Phe Asp Asn Phe Lys Asp Asn Gln 
    50                  55                  60                  


Ile Ile Gln Arg Ser Met Asp Thr Ile Lys Glu Asp Met Leu Gly Lys 
65                  70                  75                  80  


Phe Leu Asn Ser Ser Thr Ser Lys Arg Glu Asp Phe Leu Lys Leu Ile 
                85                  90                  95      


Gln Ile Pro Val Asn Asp Leu Gln Val Gln Arg Lys Ala Ile Asn Glu 
            100                 105                 110         


Leu Ile Lys Val Met Asn Asp Leu Ser Pro Arg Ser Asn Leu Arg Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly Arg Arg Ala Ser Lys 
    130                 135                 140             


<210>  192
<211>  144
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Felis interferon-gamma protein.


<400>  192

Gln Ala Met Phe Phe Lys Glu Ile Glu Glu Leu Lys Gly Tyr Phe Asn 
1               5                   10                  15      


Ala Ser Asn Pro Asp Val Ala Asp Gly Gly Ser Leu Phe Val Asp Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Glu Glu Ser Asp Lys Thr Ile Ile Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Leu Lys Met Phe Glu Asn Leu Lys Asp Asp Asp 
    50                  55                  60                  


Gln Arg Ile Gln Arg Ser Met Asp Thr Ile Lys Glu Asp Met Leu Asp 
65                  70                  75                  80  


Lys Leu Leu Asn Thr Ser Ser Ser Lys Arg Asp Asp Phe Leu Lys Leu 
                85                  90                  95      


Ile Gln Ile Pro Val Asn Asp Leu Gln Val Gln Arg Lys Ala Ile Asn 
            100                 105                 110         


Glu Leu Phe Lys Val Met Asn Asp Leu Ser Pro Arg Ser Asn Leu Arg 
        115                 120                 125             


Lys Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly Arg Arg Ala Ser Lys 
    130                 135                 140                 


<210>  193
<211>  166
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine interferon-alpha A protein.


<400>  193

Cys His Leu Pro His Thr His Ser Leu Ala Asn Arg Arg Val Leu Met 
1               5                   10                  15      


Leu Leu Gln Gln Leu Arg Arg Val Ser Pro Ser Ser Cys Leu Gln Asp 
            20                  25                  30          


Arg Asn Asp Phe Glu Phe Leu Gln Glu Ala Leu Gly Gly Ser Gln Leu 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Val Thr Gln His Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Pro Ala Thr Trp Asp Lys Ser 
65                  70                  75                  80  


Leu Leu Asp Lys Leu Arg Ala Ala Leu Asp Gln Gln Leu Thr Asp Leu 
                85                  90                  95      


Gln Ala Cys Leu Thr Gln Glu Glu Gly Leu Arg Gly Ala Pro Leu Leu 
            100                 105                 110         


Lys Glu Asp Ser Ser Leu Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Arg His Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ala Phe Ser Ser Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Ser Phe Arg Arg Lys Asp 
                165     


<210>  194
<211>  164
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Canine interferon-alpha 1 of 2 protein.


<400>  194

Cys His Leu Pro Asp Thr His Gly Leu Arg Asn Trp Arg Val Leu Thr 
1               5                   10                  15      


Leu Leu Gly Gln Met Arg Arg Leu Ser Ala Gly Ser Cys Asp His Tyr 
            20                  25                  30          


Thr Asn Asp Phe Ala Phe Pro Lys Glu Leu Phe Asp Gly Gln Arg Leu 
        35                  40                  45              


Gln Glu Ala Gln Ala Leu Ser Val Val His Val Met Thr Gln Lys Val 
    50                  55                  60                  


Phe His Leu Phe Cys Pro Asp Thr Ser Ser Ala Pro Trp Asn Met Thr 
65                  70                  75                  80  


Leu Leu Glu Glu Leu Cys Ser Gly Leu Ser Glu Gln Leu Asp Asp Leu 
                85                  90                  95      


Glu Ala Cys Pro Leu Gln Glu Ala Gly Leu Ala Glu Thr Pro Leu Met 
            100                 105                 110         


His Glu Asp Ser Thr Leu Arg Thr Tyr Phe Gln Arg Ile Ser Leu Tyr 
        115                 120                 125             


Leu Gln Asp Arg Asn His Ser Pro Cys Ala Trp Glu Met Val Arg Ala 
    130                 135                 140                 


Glu Ile Gly Arg Ser Phe Phe Ser Ser Thr Ile Leu Gln Glu Arg Ile 
145                 150                 155                 160 


Arg Arg Arg Lys 
                


<210>  195
<211>  171
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Feline interferon-alpha protein.


<400>  195

Cys Asp Leu Pro Gln Thr His Gly Leu Leu Asn Arg Arg Ala Leu Thr 
1               5                   10                  15      


Leu Leu Gly Gln Met Arg Arg Leu Pro Ala Ser Ser Cys Gln Lys Asp 
            20                  25                  30          


Arg Asn Asp Phe Ala Phe Pro Gln Asp Val Phe Gly Gly Asp Gln Ser 
        35                  40                  45              


His Lys Ala Gln Ala Leu Ser Val Val His Val Thr Asn Gln Lys Ile 
    50                  55                  60                  


Phe His Phe Phe Cys Thr Glu Ala Ser Ser Ser Ala Ala Trp Asn Thr 
65                  70                  75                  80  


Thr Leu Leu Glu Glu Phe Cys Thr Gly Leu Asp Arg Gln Leu Thr Arg 
                85                  90                  95      


Leu Glu Ala Cys Val Leu Gln Glu Val Glu Glu Gly Glu Ala Pro Leu 
            100                 105                 110         


Thr Asn Glu Asp Ile His Pro Glu Asp Ser Ile Leu Arg Asn Tyr Phe 
        115                 120                 125             


Gln Arg Leu Ser Leu Tyr Leu Gln Glu Lys Lys Tyr Ser Pro Cys Ala 
    130                 135                 140                 


Trp Glu Ile Val Arg Ala Glu Ile Met Arg Ser Leu Tyr Tyr Ser Ser 
145                 150                 155                 160 


Thr Ala Leu Gln Lys Arg Leu Arg Ser Glu Lys 
                165                 170     


<210>  196
<211>  126
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine Granulocyte-macrophage colony-stimulating factor protein.


<400>  196

Ala Pro Thr Arg Pro Pro Asn Thr Ala Thr Arg Pro Trp Gln His Val 
1               5                   10                  15      


Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu Asn His Ser Ser Asp Thr 
            20                  25                  30          


Asp Ala Val Met Asn Asp Thr Glu Val Val Ser Glu Lys Phe Asp Ser 
        35                  40                  45              


Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Lys Leu Tyr Lys Asn Gly 
    50                  55                  60                  


Leu Gln Gly Ser Leu Thr Ser Leu Met Gly Ser Leu Thr Met Met Ala 
65                  70                  75                  80  


Thr His Tyr Glu Lys His Cys Pro Pro Thr Pro Glu Thr Ser Cys Gly 
                85                  90                  95      


Thr Gln Phe Ile Ser Phe Lys Asn Phe Lys Glu Asp Leu Lys Glu Phe 
            100                 105                 110         


Leu Phe Ile Ile Pro Phe Asp Cys Trp Glu Pro Ala Gln Lys 
        115                 120                 125     


<210>  197
<211>  127
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Canine Granulocyte-macrophage colony-stimulating factor protein.


<400>  197

Ala Pro Thr Arg Ser Pro Thr Leu Val Thr Arg Pro Ser Gln His Val 
1               5                   10                  15      


Asp Ala Ile Gln Glu Ala Leu Ser Leu Leu Asn Asn Ser Asn Asp Val 
            20                  25                  30          


Thr Ala Val Met Asn Lys Ala Val Lys Val Val Ser Glu Val Phe Asp 
        35                  40                  45              


Pro Glu Gly Pro Thr Cys Leu Glu Thr Arg Leu Gln Leu Tyr Lys Glu 
    50                  55                  60                  


Gly Leu Gln Gly Ser Leu Thr Ser Leu Lys Asn Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Asn His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Ser Pro Cys 
                85                  90                  95      


Ala Thr Gln Asn Ile Asn Phe Lys Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp Lys Pro Val Lys Lys 
        115                 120                 125         


<210>  198
<211>  127
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Feline GM-CSF protein.


<400>  198

Ala Pro Thr Ser Ser Pro Ser Ser Val Thr Arg Pro Trp Gln His Val 
1               5                   10                  15      


Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu Asn Asn Ser Ser Glu Ile 
            20                  25                  30          


Thr Ala Val Met Asn Glu Ala Val Glu Val Val Ser Glu Met Phe Asp 
        35                  40                  45              


Pro Glu Glu Pro Lys Cys Met Gln Thr His Leu Lys Leu Tyr Glu Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Ile Ser Leu Lys Glu Pro Leu Arg Met Met 
65                  70                  75                  80  


Ala Asn His Tyr Lys Gln His Cys Pro Leu Thr Pro Glu Thr Pro Cys 
                85                  90                  95      


Glu Thr Gln Thr Ile Thr Phe Lys Asn Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp Glu Pro Asp Gln Lys 
        115                 120                 125         


<210>  199
<211>  174
<212>  PRT
<213>  Bos taurus

<220>
<223>  This is the amino acid sequence of Bovine Granulocyte colony-stimulating factor protein.


<400>  199

Thr Pro Leu Gly Pro Ala Arg Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Ile Gln Ala Asp Gly Ala Glu Leu Gln 
            20                  25                  30          


Glu Arg Leu Cys Ala Ala His Lys Leu Cys His Pro Glu Glu Leu Met 
        35                  40                  45              


Leu Leu Arg His Ser Leu Gly Ile Pro Gln Ala Pro Leu Ser Ser Cys 
    50                  55                  60                  


Ser Ser Gln Ser Leu Gln Leu Thr Ser Cys Leu Asn Gln Leu His Gly 
65                  70                  75                  80  


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ala Gly Ile Ser 
                85                  90                  95      


Pro Glu Leu Ala Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Thr Asp 
            100                 105                 110         


Phe Ala Thr Asn Ile Trp Leu Gln Met Glu Asp Leu Gly Ala Ala Pro 
        115                 120                 125             


Ala Val Gln Pro Thr Gln Gly Ala Met Pro Thr Phe Thr Ser Ala Phe 
    130                 135                 140                 


Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser Gln Leu His Arg Phe 
145                 150                 155                 160 


Leu Glu Leu Ala Tyr Arg Gly Leu Arg Tyr Leu Ala Glu Pro 
                165                 170                 


<210>  200
<211>  175
<212>  PRT
<213>  Canis lupus familiaris

<220>
<223>  This is the amino acid sequence of Canine Granulocyte colony-stimulating factor protein.


<400>  200

Met Ala Pro Leu Gly Pro Thr Gly Pro Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Met Arg Lys Val Gln Ala Asp Gly Thr Ala Leu 
            20                  25                  30          


Gln Glu Thr Leu Cys Ala Thr His Gln Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ala Leu Gly Ile Pro Gln Pro Pro Leu Ser Ser 
    50                  55                  60                  


Cys Ser Ser Gln Ala Leu Gln Leu Met Gly Cys Leu Arg Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ala Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Ala Pro Thr Leu Asp Thr Leu Gln Leu Asp Thr Thr 
            100                 105                 110         


Asp Phe Ala Ile Asn Ile Trp Gln Gln Met Glu Asp Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Val Pro Pro Thr Gln Gly Thr Met Pro Ala Phe Thr Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser Asn Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Leu Ala Tyr Arg Ala Leu Arg His Phe Ala Lys Pro 
                165                 170                 175 


<210>  201
<211>  174
<212>  PRT
<213>  Felis catus

<220>
<223>  This is the amino acid sequence of Feline Granulocyte colony-stimulating factor protein.


<400>  201

Thr Pro Leu Gly Pro Thr Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Val Gln Ala Asp Gly Thr Ala Leu Gln 
            20                  25                  30          


Glu Arg Leu Cys Ala Ala His Lys Leu Cys His Pro Glu Glu Leu Val 
        35                  40                  45              


Leu Leu Gly His Ala Leu Gly Ile Pro Gln Ala Pro Leu Ser Ser Cys 
    50                  55                  60                  


Ser Ser Gln Ala Leu Gln Leu Thr Gly Cys Leu Arg Gln Leu His Ser 
65                  70                  75                  80  


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ala Gly Ile Ser 
                85                  90                  95      


Pro Glu Leu Ala Pro Thr Leu Asp Met Leu Gln Leu Asp Ile Thr Asp 
            100                 105                 110         


Phe Ala Ile Asn Ile Trp Gln Gln Met Glu Asp Val Gly Met Ala Pro 
        115                 120                 125             


Ala Val Pro Pro Thr Gln Gly Thr Met Pro Thr Phe Thr Ser Ala Phe 
    130                 135                 140                 


Gln Arg Arg Ala Gly Gly Thr Leu Val Ala Ser Asn Leu Gln Ser Phe 
145                 150                 155                 160 


Leu Glu Val Ala Tyr Arg Ala Leu Arg His Phe Thr Lys Pro 
                165                 170                 


<210>  202
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of pig IL-31 polyprotein.

<400>  202

Met Ala Pro Thr Ser Val Pro Ser Pro Glu Glu Gln Lys Gly Ile Ile 
1               5                   10                  15      


Lys Glu Leu Gln Ala Ser Val Lys Lys Val Leu Lys Asp Tyr Glu Glu 
            20                  25                  30          


Lys Glu Lys Gly Val Gln Glu Gln Glu Arg Phe Gln Ile Pro Cys Leu 
        35                  40                  45              


Thr Phe Asn Pro Gln Ser Pro His Asn Ile Glu Ser Ser Ala Ile Leu 
    50                  55                  60                  


Pro Tyr Leu Arg Ala Ile Lys Arg Ser Phe Asp Asn Asp Asp Asp Ile 
65                  70                  75                  80  


Ile Asp Ile Ile Asn His Leu His Lys Leu Lys Phe Gln Gln Gly Pro 
                85                  90                  95      


Glu Thr Thr Val Pro Val Pro Thr Asn Ser Phe Glu Gly Lys Ser Phe 
            100                 105                 110         


Thr Leu Ser Ile Leu Lys Ala Phe Ser Lys Cys Leu Thr Ser Asp Phe 
        115                 120                 125             


Asn Ser His Asp Pro Arg Arg Gly Gln Ser Gly Ser Gly Gly Gln Tyr 
    130                 135                 140                 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser 
145                 150                 155                 160 


Gly Met Ala Pro Thr Ser Val Pro Ser Pro Glu Glu Gln Lys Gly Ile 
                165                 170                 175     


Ile Lys Glu Leu Gln Ala Ser Val Lys Lys Val Leu Lys Asp Tyr Glu 
            180                 185                 190         


Glu Lys Glu Lys Gly Val Gln Glu Gln Glu Arg Phe Gln Ile Pro Cys 
        195                 200                 205             


Leu Thr Phe Asn Pro Gln Ser Pro His Asn Ile Glu Ser Ser Ala Ile 
    210                 215                 220                 


Leu Pro Tyr Leu Arg Ala Ile Lys Arg Ser Phe Asp Asn Asp Asp Asp 
225                 230                 235                 240 


Ile Ile Asp Ile Ile Asn His Leu His Lys Leu Lys Phe Gln Gln Gly 
                245                 250                 255     


Pro Glu Thr Thr Val Pro Val Pro Thr Asn Ser Phe Glu Gly Lys Ser 
            260                 265                 270         


Phe Thr Leu Ser Ile Leu Lys Ala Phe Ser Lys Cys Leu Thr Ser Asp 
        275                 280                 285             


Phe Asn Ser His Asp Pro Arg Arg Gly Gln Ser Ala Gly Ser Gly Phe 
    290                 295                 300                 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
305                 310                 315                 320 


Ser His Leu Glu Ser Gly Gly Ser Met Ala Pro Thr Ser Val Pro Ser 
                325                 330                 335     


Pro Glu Glu Gln Lys Gly Ile Ile Lys Glu Leu Gln Ala Ser Val Lys 
            340                 345                 350         


Lys Val Leu Lys Asp Tyr Glu Glu Lys Glu Lys Gly Val Gln Glu Gln 
        355                 360                 365             


Glu Arg Phe Gln Ile Pro Cys Leu Thr Phe Asn Pro Gln Ser Pro His 
    370                 375                 380                 


Asn Ile Glu Ser Ser Ala Ile Leu Pro Tyr Leu Arg Ala Ile Lys Arg 
385                 390                 395                 400 


Ser Phe Asp Asn Asp Asp Asp Ile Ile Asp Ile Ile Asn His Leu His 
                405                 410                 415     


Lys Leu Lys Phe Gln Gln Gly Pro Glu Thr Thr Val Pro Val Pro Thr 
            420                 425                 430         


Asn Ser Phe Glu Gly Lys Ser Phe Thr Leu Ser Ile Leu Lys Ala Phe 
        435                 440                 445             


Ser Lys Cys Leu Thr Ser Asp Phe Asn Ser His Asp Pro Arg Arg Gly 
    450                 455                 460                 


Gln Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu 
465                 470                 475                 480 


Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln 
                485                 490                 495     


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His 
            500                 505                 510         


His His His His 
        515     


<210>  203
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-31 polyprotein.

<400>  203

Ser His Thr Leu Pro Val Arg Leu Leu Arg Pro Ser Asp Asp Val Gln 
1               5                   10                  15      


Lys Ile Val Glu Glu Leu Gln Ser Leu Ser Lys Met Leu Leu Lys Asp 
            20                  25                  30          


Val Glu Glu Glu Lys Gly Val Leu Val Ser Gln Asn Tyr Thr Leu Pro 
        35                  40                  45              


Cys Leu Ser Pro Asp Ala Gln Pro Pro Asn Asn Ile His Ser Pro Ala 
    50                  55                  60                  


Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln Leu Asp Asn Lys Ser Val 
65                  70                  75                  80  


Ile Asp Glu Ile Ile Glu His Leu Asp Lys Leu Ile Phe Gln Asp Ala 
                85                  90                  95      


Pro Glu Thr Asn Ile Ser Val Pro Thr Asp Thr His Glu Cys Lys Arg 
            100                 105                 110         


Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser Glu Cys Met Asp Leu Ala 
        115                 120                 125             


Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln Ala Thr Thr Gly Ser Gly 
    130                 135                 140                 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
145                 150                 155                 160 


Ala Gly Ser Gly Ser His Thr Leu Pro Val Arg Leu Leu Arg Pro Ser 
                165                 170                 175     


Asp Asp Val Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser Lys Met 
            180                 185                 190         


Leu Leu Lys Asp Val Glu Glu Glu Lys Gly Val Leu Val Ser Gln Asn 
        195                 200                 205             


Tyr Thr Leu Pro Cys Leu Ser Pro Asp Ala Gln Pro Pro Asn Asn Ile 
    210                 215                 220                 


His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln Leu Asp 
225                 230                 235                 240 


Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys Leu Ile 
                245                 250                 255     


Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp Thr His 
            260                 265                 270         


Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser Glu Cys 
        275                 280                 285             


Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln Ala Thr 
    290                 295                 300                 


Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
305                 310                 315                 320 


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Ser His 
                325                 330                 335     


Thr Leu Pro Val Arg Leu Leu Arg Pro Ser Asp Asp Val Gln Lys Ile 
            340                 345                 350         


Val Glu Glu Leu Gln Ser Leu Ser Lys Met Leu Leu Lys Asp Val Glu 
        355                 360                 365             


Glu Glu Lys Gly Val Leu Val Ser Gln Asn Tyr Thr Leu Pro Cys Leu 
    370                 375                 380                 


Ser Pro Asp Ala Gln Pro Pro Asn Asn Ile His Ser Pro Ala Ile Arg 
385                 390                 395                 400 


Ala Tyr Leu Lys Thr Ile Arg Gln Leu Asp Asn Lys Ser Val Ile Asp 
                405                 410                 415     


Glu Ile Ile Glu His Leu Asp Lys Leu Ile Phe Gln Asp Ala Pro Glu 
            420                 425                 430         


Thr Asn Ile Ser Val Pro Thr Asp Thr His Glu Cys Lys Arg Phe Ile 
        435                 440                 445             


Leu Thr Ile Ser Gln Gln Phe Ser Glu Cys Met Asp Leu Ala Leu Lys 
    450                 455                 460                 


Ser Leu Thr Ser Gly Ala Gln Gln Ala Thr Thr Ala Gly Ser Gly Phe 
465                 470                 475                 480 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
                485                 490                 495     


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
            500                 505                 510         


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
        515                 520                 525 


<210>  204
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-4 polyprotein.

<400>  204

Gln Asn Phe Asn Asn Thr Leu Lys Glu Ile Ile Lys Thr Leu Asn Ile 
1               5                   10                  15      


Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val Met Asp Val 
            20                  25                  30          


Leu Ala Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala 
        35                  40                  45              


Thr Thr Val Leu Arg Gln Ile Tyr Thr His His Asn Cys Ser Thr Lys 
    50                  55                  60                  


Phe Leu Lys Gly Leu Asp Arg Asn Leu Ser Ser Met Ala Asn Arg Thr 
65                  70                  75                  80  


Cys Ser Val Asn Glu Val Lys Lys Cys Thr Leu Lys Asp Phe Leu Glu 
                85                  90                  95      


Arg Leu Lys Ala Ile Met Gln Lys Lys Tyr Ser Lys His Gly Ser Gly 
            100                 105                 110         


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
        115                 120                 125             


Ala Gly Ser Gly Gln Asn Phe Asn Asn Thr Leu Lys Glu Ile Ile Lys 
    130                 135                 140                 


Thr Leu Asn Ile Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr 
145                 150                 155                 160 


Val Met Asp Val Leu Ala Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile 
                165                 170                 175     


Phe Cys Arg Ala Thr Thr Val Leu Arg Gln Ile Tyr Thr His His Asn 
            180                 185                 190         


Cys Ser Thr Lys Phe Leu Lys Gly Leu Asp Arg Asn Leu Ser Ser Met 
        195                 200                 205             


Ala Asn Arg Thr Cys Ser Val Asn Glu Val Lys Lys Cys Thr Leu Lys 
    210                 215                 220                 


Asp Phe Leu Glu Arg Leu Lys Ala Ile Met Gln Lys Lys Tyr Ser Lys 
225                 230                 235                 240 


His Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
                245                 250                 255     


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Gln Asn 
            260                 265                 270         


Phe Asn Asn Thr Leu Lys Glu Ile Ile Lys Thr Leu Asn Ile Leu Thr 
        275                 280                 285             


Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val Met Asp Val Leu Ala 
    290                 295                 300                 


Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala Thr Thr 
305                 310                 315                 320 


Val Leu Arg Gln Ile Tyr Thr His His Asn Cys Ser Thr Lys Phe Leu 
                325                 330                 335     


Lys Gly Leu Asp Arg Asn Leu Ser Ser Met Ala Asn Arg Thr Cys Ser 
            340                 345                 350         


Val Asn Glu Val Lys Lys Cys Thr Leu Lys Asp Phe Leu Glu Arg Leu 
        355                 360                 365             


Lys Ala Ile Met Gln Lys Lys Tyr Ser Lys His Ala Gly Ser Gly Phe 
    370                 375                 380                 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
385                 390                 395                 400 


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
                405                 410                 415     


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
            420                 425                 


<210>  205
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of pig IL-4 polyprotein.

<400>  205

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ile 
1               5                   10                  15      


Leu Thr Ala Arg Lys Asn Ser Cys Met Glu Leu Pro Val Thr Asp Val 
            20                  25                  30          


Phe Ala Ala Pro Glu Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ser Thr Val Leu Arg His Ile Tyr Arg His His Thr Cys Met Lys Ser 
    50                  55                  60                  


Leu Leu Ser Gly Leu Asp Arg Asn Leu Ser Ser Met Ala Asn Met Thr 
65                  70                  75                  80  


Cys Ser Val His Glu Ala Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu 
                85                  90                  95      


Arg Leu Lys Thr Ile Met Lys Glu Lys Tyr Ser Lys Cys Gly Ser Gly 
            100                 105                 110         


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
        115                 120                 125             


Ala Gly Ser Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
    130                 135                 140                 


Thr Leu Asn Ile Leu Thr Ala Arg Lys Asn Ser Cys Met Glu Leu Pro 
145                 150                 155                 160 


Val Thr Asp Val Phe Ala Ala Pro Glu Asn Thr Thr Glu Lys Glu Thr 
                165                 170                 175     


Phe Cys Arg Ala Ser Thr Val Leu Arg His Ile Tyr Arg His His Thr 
            180                 185                 190         


Cys Met Lys Ser Leu Leu Ser Gly Leu Asp Arg Asn Leu Ser Ser Met 
        195                 200                 205             


Ala Asn Met Thr Cys Ser Val His Glu Ala Lys Lys Ser Thr Leu Lys 
    210                 215                 220                 


Asp Phe Leu Glu Arg Leu Lys Thr Ile Met Lys Glu Lys Tyr Ser Lys 
225                 230                 235                 240 


Cys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
                245                 250                 255     


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser His Lys 
            260                 265                 270         


Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ile Leu Thr 
        275                 280                 285             


Ala Arg Lys Asn Ser Cys Met Glu Leu Pro Val Thr Asp Val Phe Ala 
    290                 295                 300                 


Ala Pro Glu Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ser Thr 
305                 310                 315                 320 


Val Leu Arg His Ile Tyr Arg His His Thr Cys Met Lys Ser Leu Leu 
                325                 330                 335     


Ser Gly Leu Asp Arg Asn Leu Ser Ser Met Ala Asn Met Thr Cys Ser 
            340                 345                 350         


Val His Glu Ala Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg Leu 
        355                 360                 365             


Lys Thr Ile Met Lys Glu Lys Tyr Ser Lys Cys Ala Gly Ser Gly Phe 
    370                 375                 380                 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
385                 390                 395                 400 


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
                405                 410                 415     


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
            420                 425                 


<210>  206
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of chicken IL-4 polyprotein.

<400>  206

Val Pro Met Leu Cys Leu Gln Leu Ser Val Pro Leu Met Glu Ser Ile 
1               5                   10                  15      


Arg Ile Val Asn Asp Ile Gln Gly Glu Val Ser Cys Val Lys Met Asn 
            20                  25                  30          


Val Thr Asp Ile Phe Ala Asp Asn Lys Thr Asn Asn Lys Thr Glu Leu 
        35                  40                  45              


Leu Cys Lys Ala Ser Thr Ile Val Trp Glu Ser Gln His Cys His Lys 
    50                  55                  60                  


Asn Leu Gln Gly Leu Phe Leu Asn Met Arg Gln Leu Leu Asn Ala Ser 
65                  70                  75                  80  


Ser Thr Ser Leu Lys Ala Pro Cys Pro Thr Ala Ala Gly Asn Thr Thr 
                85                  90                  95      


Ser Met Glu Lys Phe Leu Ala Asp Leu Arg Thr Phe Phe His Gln Leu 
            100                 105                 110         


Ala Lys Asn Lys Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
        115                 120                 125             


Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Val Pro Met Leu Cys 
    130                 135                 140                 


Leu Gln Leu Ser Val Pro Leu Met Glu Ser Ile Arg Ile Val Asn Asp 
145                 150                 155                 160 


Ile Gln Gly Glu Val Ser Cys Val Lys Met Asn Val Thr Asp Ile Phe 
                165                 170                 175     


Ala Asp Asn Lys Thr Asn Asn Lys Thr Glu Leu Leu Cys Lys Ala Ser 
            180                 185                 190         


Thr Ile Val Trp Glu Ser Gln His Cys His Lys Asn Leu Gln Gly Leu 
        195                 200                 205             


Phe Leu Asn Met Arg Gln Leu Leu Asn Ala Ser Ser Thr Ser Leu Lys 
    210                 215                 220                 


Ala Pro Cys Pro Thr Ala Ala Gly Asn Thr Thr Ser Met Glu Lys Phe 
225                 230                 235                 240 


Leu Ala Asp Leu Arg Thr Phe Phe His Gln Leu Ala Lys Asn Lys Ala 
                245                 250                 255     


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
            260                 265                 270         


Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Val Pro Met Leu 
        275                 280                 285             


Cys Leu Gln Leu Ser Val Pro Leu Met Glu Ser Ile Arg Ile Val Asn 
    290                 295                 300                 


Asp Ile Gln Gly Glu Val Ser Cys Val Lys Met Asn Val Thr Asp Ile 
305                 310                 315                 320 


Phe Ala Asp Asn Lys Thr Asn Asn Lys Thr Glu Leu Leu Cys Lys Ala 
                325                 330                 335     


Ser Thr Ile Val Trp Glu Ser Gln His Cys His Lys Asn Leu Gln Gly 
            340                 345                 350         


Leu Phe Leu Asn Met Arg Gln Leu Leu Asn Ala Ser Ser Thr Ser Leu 
        355                 360                 365             


Lys Ala Pro Cys Pro Thr Ala Ala Gly Asn Thr Thr Ser Met Glu Lys 
    370                 375                 380                 


Phe Leu Ala Asp Leu Arg Thr Phe Phe His Gln Leu Ala Lys Asn Lys 
385                 390                 395                 400 


Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val 
                405                 410                 415     


Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile 
            420                 425                 430         


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His 
        435                 440                 445             


His His 
    450 


<210>  207
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine IL-4 polyprotein.

<400>  207

His Lys Cys Asp Ile Thr Leu Ala Glu Ile Ile Lys Thr Leu Asn Ile 
1               5                   10                  15      


Leu Thr Thr Arg Lys Asn Ser Cys Met Glu Leu Pro Val Ala Asp Val 
            20                  25                  30          


Phe Ala Ala Pro Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Val 
        35                  40                  45              


Gly Ile Glu Leu Arg Arg Ile Tyr Arg Ser His Thr Cys Leu Asn Lys 
    50                  55                  60                  


Phe Leu Gly Gly Leu Asp Arg Asn Leu Asn Ser Leu Ala Ser Lys Thr 
65                  70                  75                  80  


Cys Ser Val Asn Glu Ala Lys Thr Ser Thr Ser Thr Leu Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Leu Lys Thr Ile Met Lys Glu Lys Tyr Ser Lys Cys Gly 
            100                 105                 110         


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
        115                 120                 125             


Glu Leu Ala Gly Ser Gly His Lys Cys Asp Ile Thr Leu Ala Glu Ile 
    130                 135                 140                 


Ile Lys Thr Leu Asn Ile Leu Thr Thr Arg Lys Asn Ser Cys Met Glu 
145                 150                 155                 160 


Leu Pro Val Ala Asp Val Phe Ala Ala Pro Lys Asn Thr Thr Glu Lys 
                165                 170                 175     


Glu Thr Phe Cys Arg Val Gly Ile Glu Leu Arg Arg Ile Tyr Arg Ser 
            180                 185                 190         


His Thr Cys Leu Asn Lys Phe Leu Gly Gly Leu Asp Arg Asn Leu Asn 
        195                 200                 205             


Ser Leu Ala Ser Lys Thr Cys Ser Val Asn Glu Ala Lys Thr Ser Thr 
    210                 215                 220                 


Ser Thr Leu Lys Asp Leu Leu Glu Arg Leu Lys Thr Ile Met Lys Glu 
225                 230                 235                 240 


Lys Tyr Ser Lys Cys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
                245                 250                 255     


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
            260                 265                 270         


Gly Ser His Lys Cys Asp Ile Thr Leu Ala Glu Ile Ile Lys Thr Leu 
        275                 280                 285             


Asn Ile Leu Thr Thr Arg Lys Asn Ser Cys Met Glu Leu Pro Val Ala 
    290                 295                 300                 


Asp Val Phe Ala Ala Pro Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys 
305                 310                 315                 320 


Arg Val Gly Ile Glu Leu Arg Arg Ile Tyr Arg Ser His Thr Cys Leu 
                325                 330                 335     


Asn Lys Phe Leu Gly Gly Leu Asp Arg Asn Leu Asn Ser Leu Ala Ser 
            340                 345                 350         


Lys Thr Cys Ser Val Asn Glu Ala Lys Thr Ser Thr Ser Thr Leu Lys 
        355                 360                 365             


Asp Leu Leu Glu Arg Leu Lys Thr Ile Met Lys Glu Lys Tyr Ser Lys 
    370                 375                 380                 


Cys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
385                 390                 395                 400 


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
                405                 410                 415     


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
            420                 425                 430         


His His His 
        435 


<210>  208
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-4 Isoform 1 
       polyprotein.

<400>  208

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
    130                 135                 140                 


Ile Thr Glu Leu Ala Gly Ser Gly His Lys Cys Asp Ile Thr Leu Gln 
145                 150                 155                 160 


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
                165                 170                 175     


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
            180                 185                 190         


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
        195                 200                 205             


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
    210                 215                 220                 


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
225                 230                 235                 240 


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
                245                 250                 255     


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
            260                 265                 270         


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Ala Gly Ser Gly Phe Asn Asn 
        275                 280                 285             


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
    290                 295                 300                 


Leu Glu Ser Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile 
305                 310                 315                 320 


Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu 
                325                 330                 335     


Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys 
            340                 345                 350         


Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His 
        355                 360                 365             


His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His 
    370                 375                 380                 


Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu 
385                 390                 395                 400 


Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln 
                405                 410                 415     


Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu 
            420                 425                 430         


Lys Tyr Ser Lys Cys Ser Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr 
        435                 440                 445             


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
    450                 455                 460                 


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
465                 470                 475                 480 


Thr Glu Leu His His His His His His 
                485                 


<210>  209
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-4 Isoform 2 
       polyprotein.

<400>  209

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
            20                  25                  30          


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
        35                  40                  45              


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
    50                  55                  60                  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
65                  70                  75                  80  


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
                85                  90                  95      


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
            100                 105                 110         


Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
        115                 120                 125             


Ile Thr Glu Leu Ala Gly Ser Gly His Lys Cys Asp Ile Thr Leu Gln 
    130                 135                 140                 


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Asn Thr Thr 
145                 150                 155                 160 


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
                165                 170                 175     


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
            180                 185                 190         


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
        195                 200                 205             


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
    210                 215                 220                 


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
225                 230                 235                 240 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Ala Gly Ser Gly Phe Asn Asn 
                245                 250                 255     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            260                 265                 270         


Leu Glu Ser Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile 
        275                 280                 285             


Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Asn Thr Thr Glu Lys 
    290                 295                 300                 


Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His 
305                 310                 315                 320 


His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His 
                325                 330                 335     


Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu 
            340                 345                 350         


Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln 
        355                 360                 365             


Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu 
    370                 375                 380                 


Lys Tyr Ser Lys Cys Ser Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr 
385                 390                 395                 400 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
                405                 410                 415     


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
            420                 425                 430         


Thr Glu Leu His His His His His His 
        435                 440     


<210>  210
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-5 polyprotein.

<400>  210

Ile Ala Val Gln Ser Pro Met Asn Arg Leu Val Ala Glu Thr Leu Ala 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Leu Leu Ile Gly Asp Gly Asn Leu Met 
            20                  25                  30          


Ile Pro Thr Pro Glu His Asn Asn His Gln Leu Cys Ile Glu Glu Val 
        35                  40                  45              


Phe Gln Gly Ile Asp Thr Leu Lys Asn Arg Thr Val Pro Gly Asp Ala 
    50                  55                  60                  


Val Glu Lys Leu Phe Arg Asn Leu Ser Leu Ile Lys Glu His Ile Asp 
65                  70                  75                  80  


Arg Gln Lys Lys Lys Cys Gly Gly Glu Arg Trp Arg Val Lys Lys Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Val Phe Leu Gly Val Ile Asn Thr Glu Trp Thr 
            100                 105                 110         


Met Glu Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
        115                 120                 125             


Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ile Ala Val Gln Ser Pro 
    130                 135                 140                 


Met Asn Arg Leu Val Ala Glu Thr Leu Ala Leu Leu Ser Thr His Arg 
145                 150                 155                 160 


Thr Leu Leu Ile Gly Asp Gly Asn Leu Met Ile Pro Thr Pro Glu His 
                165                 170                 175     


Asn Asn His Gln Leu Cys Ile Glu Glu Val Phe Gln Gly Ile Asp Thr 
            180                 185                 190         


Leu Lys Asn Arg Thr Val Pro Gly Asp Ala Val Glu Lys Leu Phe Arg 
        195                 200                 205             


Asn Leu Ser Leu Ile Lys Glu His Ile Asp Arg Gln Lys Lys Lys Cys 
    210                 215                 220                 


Gly Gly Glu Arg Trp Arg Val Lys Lys Phe Leu Asp Tyr Leu Gln Val 
225                 230                 235                 240 


Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Met Glu Ser Ala Gly Ser 
                245                 250                 255     


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
            260                 265                 270         


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Ile Ala Val Gln Ser Pro 
        275                 280                 285             


Met Asn Arg Leu Val Ala Glu Thr Leu Ala Leu Leu Ser Thr His Arg 
    290                 295                 300                 


Thr Leu Leu Ile Gly Asp Gly Asn Leu Met Ile Pro Thr Pro Glu His 
305                 310                 315                 320 


Asn Asn His Gln Leu Cys Ile Glu Glu Val Phe Gln Gly Ile Asp Thr 
                325                 330                 335     


Leu Lys Asn Arg Thr Val Pro Gly Asp Ala Val Glu Lys Leu Phe Arg 
            340                 345                 350         


Asn Leu Ser Leu Ile Lys Glu His Ile Asp Arg Gln Lys Lys Lys Cys 
        355                 360                 365             


Gly Gly Glu Arg Trp Arg Val Lys Lys Phe Leu Asp Tyr Leu Gln Val 
    370                 375                 380                 


Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Met Glu Ser Ala Gly Ser 
385                 390                 395                 400 


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
                405                 410                 415     


Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
            420                 425                 430         


Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
        435                 440                 445         


<210>  211
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of pig IL-5 polyprotein.

<400>  211

Val Glu Asn Thr Met Asn Arg Leu Val Ala Glu Thr Leu Thr Leu Leu 
1               5                   10                  15      


Ser Ile His Arg Thr Leu Leu Ile Gly Asp Gly Asn Leu Met Ile Ser 
            20                  25                  30          


Thr Pro Val His Thr Asn His Gln Leu Cys Ile Glu Glu Val Phe Gln 
        35                  40                  45              


Gly Ile Asp Thr Leu Lys Asn Gln Thr Ala Arg Gly Asp Ala Val Glu 
    50                  55                  60                  


Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Glu Tyr Ile Asp Arg Gln 
65                  70                  75                  80  


Lys Lys Asn Cys Gly Gly Glu Arg Trp Arg Val Thr Gln Phe Leu Asp 
                85                  90                  95      


Tyr Leu Gln Val Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Met Glu 
            100                 105                 110         


Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
        115                 120                 125             


Ile Thr Glu Leu Ala Gly Ser Gly Val Glu Asn Thr Met Asn Arg Leu 
    130                 135                 140                 


Val Ala Glu Thr Leu Thr Leu Leu Ser Ile His Arg Thr Leu Leu Ile 
145                 150                 155                 160 


Gly Asp Gly Asn Leu Met Ile Ser Thr Pro Val His Thr Asn His Gln 
                165                 170                 175     


Leu Cys Ile Glu Glu Val Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln 
            180                 185                 190         


Thr Ala Arg Gly Asp Ala Val Glu Lys Leu Phe Gln Asn Leu Ser Leu 
        195                 200                 205             


Ile Lys Glu Tyr Ile Asp Arg Gln Lys Lys Asn Cys Gly Gly Glu Arg 
    210                 215                 220                 


Trp Arg Val Thr Gln Phe Leu Asp Tyr Leu Gln Val Phe Leu Gly Val 
225                 230                 235                 240 


Ile Asn Thr Glu Trp Thr Met Glu Ser Ala Gly Ser Gly Phe Asn Asn 
                245                 250                 255     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            260                 265                 270         


Leu Glu Ser Gly Gly Ser Val Glu Asn Thr Met Asn Arg Leu Val Ala 
        275                 280                 285             


Glu Thr Leu Thr Leu Leu Ser Ile His Arg Thr Leu Leu Ile Gly Asp 
    290                 295                 300                 


Gly Asn Leu Met Ile Ser Thr Pro Val His Thr Asn His Gln Leu Cys 
305                 310                 315                 320 


Ile Glu Glu Val Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln Thr Ala 
                325                 330                 335     


Arg Gly Asp Ala Val Glu Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys 
            340                 345                 350         


Glu Tyr Ile Asp Arg Gln Lys Lys Asn Cys Gly Gly Glu Arg Trp Arg 
        355                 360                 365             


Val Thr Gln Phe Leu Asp Tyr Leu Gln Val Phe Leu Gly Val Ile Asn 
    370                 375                 380                 


Thr Glu Trp Thr Met Glu Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr 
385                 390                 395                 400 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
                405                 410                 415     


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
            420                 425                 430         


Thr Glu Leu His His His His His His 
        435                 440     


<210>  212
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of chicken IL-5 126 aa 
       polyprotein.

<400>  212

Thr Pro Leu Arg Ser Asn Leu Ala Glu Leu Gln Thr Trp Leu Gln Gln 
1               5                   10                  15      


Ile Tyr Gln Ser Val Asp Met Leu Asn Leu Arg Ile Glu Thr Pro Val 
            20                  25                  30          


Ser Ala Asp Asp Glu Asn Cys Ile Lys Thr Leu Phe Glu Gly Thr Ala 
        35                  40                  45              


Leu Leu Lys Asn Asn Pro Glu Met Arg Arg Phe Gly Thr Phe Phe Gln 
    50                  55                  60                  


Ser Phe Asp Lys Leu Arg Pro Ser Leu Thr Ala Gln Leu Thr Gly Glu 
65                  70                  75                  80  


Gly Glu Cys Asp Thr Glu Arg Lys Asn Val Lys Lys Phe Ile Glu Lys 
                85                  90                  95      


Leu Arg Thr Phe Ile Arg Lys Leu Ser Arg Asp Ala Arg Val Gly Ser 
            100                 105                 110         


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
        115                 120                 125             


Leu Ala Gly Ser Gly Thr Pro Leu Arg Ser Asn Leu Ala Glu Leu Gln 
    130                 135                 140                 


Thr Trp Leu Gln Gln Ile Tyr Gln Ser Val Asp Met Leu Asn Leu Arg 
145                 150                 155                 160 


Ile Glu Thr Pro Val Ser Ala Asp Asp Glu Asn Cys Ile Lys Thr Leu 
                165                 170                 175     


Phe Glu Gly Thr Ala Leu Leu Lys Asn Asn Pro Glu Met Arg Arg Phe 
            180                 185                 190         


Gly Thr Phe Phe Gln Ser Phe Asp Lys Leu Arg Pro Ser Leu Thr Ala 
        195                 200                 205             


Gln Leu Thr Gly Glu Gly Glu Cys Asp Thr Glu Arg Lys Asn Val Lys 
    210                 215                 220                 


Lys Phe Ile Glu Lys Leu Arg Thr Phe Ile Arg Lys Leu Ser Arg Asp 
225                 230                 235                 240 


Ala Arg Val Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
                245                 250                 255     


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
            260                 265                 270         


Thr Pro Leu Arg Ser Asn Leu Ala Glu Leu Gln Thr Trp Leu Gln Gln 
        275                 280                 285             


Ile Tyr Gln Ser Val Asp Met Leu Asn Leu Arg Ile Glu Thr Pro Val 
    290                 295                 300                 


Ser Ala Asp Asp Glu Asn Cys Ile Lys Thr Leu Phe Glu Gly Thr Ala 
305                 310                 315                 320 


Leu Leu Lys Asn Asn Pro Glu Met Arg Arg Phe Gly Thr Phe Phe Gln 
                325                 330                 335     


Ser Phe Asp Lys Leu Arg Pro Ser Leu Thr Ala Gln Leu Thr Gly Glu 
            340                 345                 350         


Gly Glu Cys Asp Thr Glu Arg Lys Asn Val Lys Lys Phe Ile Glu Lys 
        355                 360                 365             


Leu Arg Thr Phe Ile Arg Lys Leu Ser Arg Asp Ala Arg Val Ala Gly 
    370                 375                 380                 


Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
385                 390                 395                 400 


Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
                405                 410                 415     


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
            420                 425                 430         


<210>  213
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of chicken IL-5 136 aa 
       polyprotein.

<400>  213

Thr Pro Leu Arg Ser Asn Leu Ala Glu Leu Gln Thr Trp Leu Gln Gln 
1               5                   10                  15      


Ile Tyr Gln Ser Val Asp Met Leu Val Ser Ser Ile Phe Tyr Phe Cys 
            20                  25                  30          


Ser Met Asn Leu Arg Ile Glu Thr Pro Val Ser Ala Asp Asp Glu Asn 
        35                  40                  45              


Cys Ile Lys Thr Leu Phe Glu Gly Thr Ala Leu Leu Lys Asn Asn Pro 
    50                  55                  60                  


Glu Met Arg Arg Phe Gly Thr Phe Phe Gln Ser Phe Asp Lys Leu Arg 
65                  70                  75                  80  


Pro Ser Leu Thr Ala Gln Leu Thr Gly Glu Gly Glu Cys Asp Thr Glu 
                85                  90                  95      


Arg Lys Asn Val Lys Lys Phe Ile Glu Lys Leu Arg Thr Phe Ile Arg 
            100                 105                 110         


Lys Leu Ser Arg Asp Ala Arg Val Gly Ser Gly Gly Gln Tyr Ile Lys 
        115                 120                 125             


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Thr 
    130                 135                 140                 


Pro Leu Arg Ser Asn Leu Ala Glu Leu Gln Thr Trp Leu Gln Gln Ile 
145                 150                 155                 160 


Tyr Gln Ser Val Asp Met Leu Val Ser Ser Ile Phe Tyr Phe Cys Ser 
                165                 170                 175     


Met Asn Leu Arg Ile Glu Thr Pro Val Ser Ala Asp Asp Glu Asn Cys 
            180                 185                 190         


Ile Lys Thr Leu Phe Glu Gly Thr Ala Leu Leu Lys Asn Asn Pro Glu 
        195                 200                 205             


Met Arg Arg Phe Gly Thr Phe Phe Gln Ser Phe Asp Lys Leu Arg Pro 
    210                 215                 220                 


Ser Leu Thr Ala Gln Leu Thr Gly Glu Gly Glu Cys Asp Thr Glu Arg 
225                 230                 235                 240 


Lys Asn Val Lys Lys Phe Ile Glu Lys Leu Arg Thr Phe Ile Arg Lys 
                245                 250                 255     


Leu Ser Arg Asp Ala Arg Val Ala Gly Ser Gly Phe Asn Asn Phe Thr 
            260                 265                 270         


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
        275                 280                 285             


Ser Gly Gly Ser Thr Pro Leu Arg Ser Asn Leu Ala Glu Leu Gln Thr 
    290                 295                 300                 


Trp Leu Gln Gln Ile Tyr Gln Ser Val Asp Met Leu Val Ser Ser Ile 
305                 310                 315                 320 


Phe Tyr Phe Cys Ser Met Asn Leu Arg Ile Glu Thr Pro Val Ser Ala 
                325                 330                 335     


Asp Asp Glu Asn Cys Ile Lys Thr Leu Phe Glu Gly Thr Ala Leu Leu 
            340                 345                 350         


Lys Asn Asn Pro Glu Met Arg Arg Phe Gly Thr Phe Phe Gln Ser Phe 
        355                 360                 365             


Asp Lys Leu Arg Pro Ser Leu Thr Ala Gln Leu Thr Gly Glu Gly Glu 
    370                 375                 380                 


Cys Asp Thr Glu Arg Lys Asn Val Lys Lys Phe Ile Glu Lys Leu Arg 
385                 390                 395                 400 


Thr Phe Ile Arg Lys Leu Ser Arg Asp Ala Arg Val Ala Gly Ser Gly 
                405                 410                 415     


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
            420                 425                 430         


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
        435                 440                 445             


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
    450                 455                 460         


<210>  214
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine IL-5 polyprotein.

<400>  214

Val Glu Ser Thr Met Asn Arg Leu Val Ala Glu Thr Leu Thr Leu Leu 
1               5                   10                  15      


Ser Ser His Arg Thr Leu Leu Ile Gly Asp Gly Asn Leu Met Ile Pro 
            20                  25                  30          


Thr Pro Gln His Thr Asn His Gln Leu Cys Ile Glu Glu Val Phe Gln 
        35                  40                  45              


Gly Ile Asp Thr Leu Lys Asn Gln Thr Ala Gln Gly Asp Ala Val Lys 
    50                  55                  60                  


Lys Ile Phe Gln Asn Leu Ser Leu Ile Lys Glu Tyr Ile Asp Leu Gln 
65                  70                  75                  80  


Lys Arg Lys Cys Gly Gly Glu Arg Trp Arg Val Lys Gln Phe Leu Asp 
                85                  90                  95      


Tyr Leu Gln Val Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Met Glu 
            100                 105                 110         


Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
        115                 120                 125             


Ile Thr Glu Leu Ala Gly Ser Gly Val Glu Ser Thr Met Asn Arg Leu 
    130                 135                 140                 


Val Ala Glu Thr Leu Thr Leu Leu Ser Ser His Arg Thr Leu Leu Ile 
145                 150                 155                 160 


Gly Asp Gly Asn Leu Met Ile Pro Thr Pro Gln His Thr Asn His Gln 
                165                 170                 175     


Leu Cys Ile Glu Glu Val Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln 
            180                 185                 190         


Thr Ala Gln Gly Asp Ala Val Lys Lys Ile Phe Gln Asn Leu Ser Leu 
        195                 200                 205             


Ile Lys Glu Tyr Ile Asp Leu Gln Lys Arg Lys Cys Gly Gly Glu Arg 
    210                 215                 220                 


Trp Arg Val Lys Gln Phe Leu Asp Tyr Leu Gln Val Phe Leu Gly Val 
225                 230                 235                 240 


Ile Asn Thr Glu Trp Thr Met Glu Ser Ala Gly Ser Gly Phe Asn Asn 
                245                 250                 255     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            260                 265                 270         


Leu Glu Ser Gly Gly Ser Val Glu Ser Thr Met Asn Arg Leu Val Ala 
        275                 280                 285             


Glu Thr Leu Thr Leu Leu Ser Ser His Arg Thr Leu Leu Ile Gly Asp 
    290                 295                 300                 


Gly Asn Leu Met Ile Pro Thr Pro Gln His Thr Asn His Gln Leu Cys 
305                 310                 315                 320 


Ile Glu Glu Val Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln Thr Ala 
                325                 330                 335     


Gln Gly Asp Ala Val Lys Lys Ile Phe Gln Asn Leu Ser Leu Ile Lys 
            340                 345                 350         


Glu Tyr Ile Asp Leu Gln Lys Arg Lys Cys Gly Gly Glu Arg Trp Arg 
        355                 360                 365             


Val Lys Gln Phe Leu Asp Tyr Leu Gln Val Phe Leu Gly Val Ile Asn 
    370                 375                 380                 


Thr Glu Trp Thr Met Glu Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr 
385                 390                 395                 400 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
                405                 410                 415     


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
            420                 425                 430         


Thr Glu Leu His His His His His His 
        435                 440     


<210>  215
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-5 polyprotein.

<400>  215

Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu Thr Leu Ala 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu Thr Leu Arg 
            20                  25                  30          


Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr Glu Glu Ile 
        35                  40                  45              


Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln Gly Gly Thr 
    50                  55                  60                  


Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys Tyr Ile Asp 
65                  70                  75                  80  


Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val Asn Gln Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr Glu Trp Ile 
            100                 105                 110         


Ile Glu Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
        115                 120                 125             


Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ile Pro Thr Glu Ile Pro 
    130                 135                 140                 


Thr Ser Ala Leu Val Lys Glu Thr Leu Ala Leu Leu Ser Thr His Arg 
145                 150                 155                 160 


Thr Leu Leu Ile Ala Asn Glu Thr Leu Arg Ile Pro Val Pro Val His 
                165                 170                 175     


Lys Asn His Gln Leu Cys Thr Glu Glu Ile Phe Gln Gly Ile Gly Thr 
            180                 185                 190         


Leu Glu Ser Gln Thr Val Gln Gly Gly Thr Val Glu Arg Leu Phe Lys 
        195                 200                 205             


Asn Leu Ser Leu Ile Lys Lys Tyr Ile Asp Gly Gln Lys Lys Lys Cys 
    210                 215                 220                 


Gly Glu Glu Arg Arg Arg Val Asn Gln Phe Leu Asp Tyr Leu Gln Glu 
225                 230                 235                 240 


Phe Leu Gly Val Met Asn Thr Glu Trp Ile Ile Glu Ser Ala Gly Ser 
                245                 250                 255     


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
            260                 265                 270         


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Ile Pro Thr Glu Ile Pro 
        275                 280                 285             


Thr Ser Ala Leu Val Lys Glu Thr Leu Ala Leu Leu Ser Thr His Arg 
    290                 295                 300                 


Thr Leu Leu Ile Ala Asn Glu Thr Leu Arg Ile Pro Val Pro Val His 
305                 310                 315                 320 


Lys Asn His Gln Leu Cys Thr Glu Glu Ile Phe Gln Gly Ile Gly Thr 
                325                 330                 335     


Leu Glu Ser Gln Thr Val Gln Gly Gly Thr Val Glu Arg Leu Phe Lys 
            340                 345                 350         


Asn Leu Ser Leu Ile Lys Lys Tyr Ile Asp Gly Gln Lys Lys Lys Cys 
        355                 360                 365             


Gly Glu Glu Arg Arg Arg Val Asn Gln Phe Leu Asp Tyr Leu Gln Glu 
    370                 375                 380                 


Phe Leu Gly Val Met Asn Thr Glu Trp Ile Ile Glu Ser Ala Gly Ser 
385                 390                 395                 400 


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
                405                 410                 415     


Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
            420                 425                 430         


Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
        435                 440                 445         


<210>  216
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-13 polyprotein.

<400>  216

Ser Pro Gly Pro His Ser Arg Arg Glu Leu Lys Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Val Ser Leu Cys Asn Gly Ser Met 
            20                  25                  30          


Val Trp Ser Val Asn Leu Thr Thr Gly Met Tyr Cys Ala Ala Leu Glu 
        35                  40                  45              


Ser Leu Ile Asn Val Ser Asp Cys Thr Ala Ile Gln Arg Thr Gln Arg 
    50                  55                  60                  


Met Leu Lys Ala Leu Cys Thr Gln Lys Pro Ser Ala Gly Gln Thr Ala 
65                  70                  75                  80  


Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile Gln Leu Val Lys 
                85                  90                  95      


Asn Leu Leu Asn His Leu Arg Arg Asn Phe Arg His Gly Asn Phe Lys 
            100                 105                 110         


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
        115                 120                 125             


Thr Glu Leu Ala Gly Ser Gly Ser Pro Gly Pro His Ser Arg Arg Glu 
    130                 135                 140                 


Leu Lys Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Val 
145                 150                 155                 160 


Ser Leu Cys Asn Gly Ser Met Val Trp Ser Val Asn Leu Thr Thr Gly 
                165                 170                 175     


Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Asp Cys Thr 
            180                 185                 190         


Ala Ile Gln Arg Thr Gln Arg Met Leu Lys Ala Leu Cys Thr Gln Lys 
        195                 200                 205             


Pro Ser Ala Gly Gln Thr Ala Ser Glu Arg Ser Arg Asp Thr Lys Ile 
    210                 215                 220                 


Glu Val Ile Gln Leu Val Lys Asn Leu Leu Asn His Leu Arg Arg Asn 
225                 230                 235                 240 


Phe Arg His Gly Asn Phe Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                245                 250                 255     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            260                 265                 270         


Ser Gly Gly Ser Ser Pro Gly Pro His Ser Arg Arg Glu Leu Lys Glu 
        275                 280                 285             


Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Val Ser Leu Cys 
    290                 295                 300                 


Asn Gly Ser Met Val Trp Ser Val Asn Leu Thr Thr Gly Met Tyr Cys 
305                 310                 315                 320 


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Asp Cys Thr Ala Ile Gln 
                325                 330                 335     


Arg Thr Gln Arg Met Leu Lys Ala Leu Cys Thr Gln Lys Pro Ser Ala 
            340                 345                 350         


Gly Gln Thr Ala Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile 
        355                 360                 365             


Gln Leu Val Lys Asn Leu Leu Asn His Leu Arg Arg Asn Phe Arg His 
    370                 375                 380                 


Gly Asn Phe Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
385                 390                 395                 400 


Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly 
                405                 410                 415     


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
            420                 425                 430         


His His His His His His 
        435             


<210>  217
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of pig IL-13 polyprotein.

<400>  217

Ser Pro Gly Pro Val Pro Pro His Ser Thr Ala Leu Lys Glu Leu Ile 
1               5                   10                  15      


Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Thr Pro Leu Cys Asn 
            20                  25                  30          


Gly Ser Met Val Trp Ser Val Asn Leu Thr Thr Ser Met Gln Tyr Cys 
        35                  40                  45              


Ala Ala Leu Glu Ser Leu Ile Asn Ile Ser Asp Cys Ser Ala Ile Gln 
    50                  55                  60                  


Lys Thr Gln Arg Met Leu Ser Ala Leu Cys Ser His Lys Pro Pro Ser 
65                  70                  75                  80  


Glu Gln Val Pro Gly Lys His Ile Arg Asp Thr Lys Ile Glu Val Ala 
                85                  90                  95      


Gln Phe Val Lys Asp Leu Leu Lys His Leu Arg Met Ile Phe Arg His 
            100                 105                 110         


Gly Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
        115                 120                 125             


Ile Thr Glu Leu Ala Gly Ser Gly Ser Pro Gly Pro Val Pro Pro His 
    130                 135                 140                 


Ser Thr Ala Leu Lys Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln 
145                 150                 155                 160 


Asn Gln Lys Thr Pro Leu Cys Asn Gly Ser Met Val Trp Ser Val Asn 
                165                 170                 175     


Leu Thr Thr Ser Met Gln Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn 
            180                 185                 190         


Ile Ser Asp Cys Ser Ala Ile Gln Lys Thr Gln Arg Met Leu Ser Ala 
        195                 200                 205             


Leu Cys Ser His Lys Pro Pro Ser Glu Gln Val Pro Gly Lys His Ile 
    210                 215                 220                 


Arg Asp Thr Lys Ile Glu Val Ala Gln Phe Val Lys Asp Leu Leu Lys 
225                 230                 235                 240 


His Leu Arg Met Ile Phe Arg His Gly Ala Gly Ser Gly Phe Asn Asn 
                245                 250                 255     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            260                 265                 270         


Leu Glu Ser Gly Gly Ser Ser Pro Gly Pro Val Pro Pro His Ser Thr 
        275                 280                 285             


Ala Leu Lys Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln 
    290                 295                 300                 


Lys Thr Pro Leu Cys Asn Gly Ser Met Val Trp Ser Val Asn Leu Thr 
305                 310                 315                 320 


Thr Ser Met Gln Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Ile Ser 
                325                 330                 335     


Asp Cys Ser Ala Ile Gln Lys Thr Gln Arg Met Leu Ser Ala Leu Cys 
            340                 345                 350         


Ser His Lys Pro Pro Ser Glu Gln Val Pro Gly Lys His Ile Arg Asp 
        355                 360                 365             


Thr Lys Ile Glu Val Ala Gln Phe Val Lys Asp Leu Leu Lys His Leu 
    370                 375                 380                 


Arg Met Ile Phe Arg His Gly Ala Gly Ser Gly Phe Asn Asn Phe Thr 
385                 390                 395                 400 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
                405                 410                 415     


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
            420                 425                 430         


Thr Glu Leu His His His His His His 
        435                 440     


<210>  218
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of chicken IL-13 polyprotein.

<400>  218

Thr Pro Leu Ala Met Asn Leu Ser Lys Leu Lys Leu Ser Asp Ile Thr 
1               5                   10                  15      


Gln Gly Ile Gln Lys Leu Asn Arg Gly Val Gln Leu Ser Glu Gln Glu 
            20                  25                  30          


Leu Leu Cys Gln Ala Ala Thr Val Leu Asp Asn Met Thr Asp Cys Lys 
        35                  40                  45              


Lys Asp Tyr Glu Pro Leu Ile Thr Ser Leu Lys Ser Leu His Gly Met 
    50                  55                  60                  


Thr Asn Cys Pro Pro Ser Thr Asp Asn Glu Ile Tyr Leu Arg Asn Phe 
65                  70                  75                  80  


Leu Pro Ala Leu Gly Asn Tyr Thr Gln Ala Leu Tyr Arg Arg Ile Ser 
                85                  90                  95      


Ala Thr Ala Ala Asn Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
            100                 105                 110         


Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Thr Pro Leu Ala 
        115                 120                 125             


Met Asn Leu Ser Lys Leu Lys Leu Ser Asp Ile Thr Gln Gly Ile Gln 
    130                 135                 140                 


Lys Leu Asn Arg Gly Val Gln Leu Ser Glu Gln Glu Leu Leu Cys Gln 
145                 150                 155                 160 


Ala Ala Thr Val Leu Asp Asn Met Thr Asp Cys Lys Lys Asp Tyr Glu 
                165                 170                 175     


Pro Leu Ile Thr Ser Leu Lys Ser Leu His Gly Met Thr Asn Cys Pro 
            180                 185                 190         


Pro Ser Thr Asp Asn Glu Ile Tyr Leu Arg Asn Phe Leu Pro Ala Leu 
        195                 200                 205             


Gly Asn Tyr Thr Gln Ala Leu Tyr Arg Arg Ile Ser Ala Thr Ala Ala 
    210                 215                 220                 


Asn Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
225                 230                 235                 240 


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Thr Pro 
                245                 250                 255     


Leu Ala Met Asn Leu Ser Lys Leu Lys Leu Ser Asp Ile Thr Gln Gly 
            260                 265                 270         


Ile Gln Lys Leu Asn Arg Gly Val Gln Leu Ser Glu Gln Glu Leu Leu 
        275                 280                 285             


Cys Gln Ala Ala Thr Val Leu Asp Asn Met Thr Asp Cys Lys Lys Asp 
    290                 295                 300                 


Tyr Glu Pro Leu Ile Thr Ser Leu Lys Ser Leu His Gly Met Thr Asn 
305                 310                 315                 320 


Cys Pro Pro Ser Thr Asp Asn Glu Ile Tyr Leu Arg Asn Phe Leu Pro 
                325                 330                 335     


Ala Leu Gly Asn Tyr Thr Gln Ala Leu Tyr Arg Arg Ile Ser Ala Thr 
            340                 345                 350         


Ala Ala Asn Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
        355                 360                 365             


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly 
    370                 375                 380                 


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His 
385                 390                 395                 400 


His His His His His 
                405 


<210>  219
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine IL-13 polyprotein.

<400>  219

Ser Pro Ser Pro Val Pro Ser Ala Thr Ala Leu Lys Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Val Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Leu Asn Leu Thr Ser Ser Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Asp Ser Leu Ile Ser Ile Ser Asn Cys Ser Val Ile Gln Arg Thr 
    50                  55                  60                  


Lys Arg Met Leu Asn Ala Leu Cys Pro His Lys Pro Ser Ala Lys Gln 
65                  70                  75                  80  


Val Ser Ser Glu Tyr Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Leu Lys Asp Leu Leu Arg His Ser Arg Ile Val Phe Arg Asn Glu Arg 
            100                 105                 110         


Phe Asn Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
        115                 120                 125             


Gly Ile Thr Glu Leu Ala Gly Ser Gly Ser Pro Ser Pro Val Pro Ser 
    130                 135                 140                 


Ala Thr Ala Leu Lys Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln 
145                 150                 155                 160 


Asn Gln Lys Val Pro Leu Cys Asn Gly Ser Met Val Trp Ser Leu Asn 
                165                 170                 175     


Leu Thr Ser Ser Met Tyr Cys Ala Ala Leu Asp Ser Leu Ile Ser Ile 
            180                 185                 190         


Ser Asn Cys Ser Val Ile Gln Arg Thr Lys Arg Met Leu Asn Ala Leu 
        195                 200                 205             


Cys Pro His Lys Pro Ser Ala Lys Gln Val Ser Ser Glu Tyr Val Arg 
    210                 215                 220                 


Asp Thr Lys Ile Glu Val Ala Gln Phe Leu Lys Asp Leu Leu Arg His 
225                 230                 235                 240 


Ser Arg Ile Val Phe Arg Asn Glu Arg Phe Asn Ala Gly Ser Gly Phe 
                245                 250                 255     


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
            260                 265                 270         


Ser His Leu Glu Ser Gly Gly Ser Ser Pro Ser Pro Val Pro Ser Ala 
        275                 280                 285             


Thr Ala Leu Lys Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn 
    290                 295                 300                 


Gln Lys Val Pro Leu Cys Asn Gly Ser Met Val Trp Ser Leu Asn Leu 
305                 310                 315                 320 


Thr Ser Ser Met Tyr Cys Ala Ala Leu Asp Ser Leu Ile Ser Ile Ser 
                325                 330                 335     


Asn Cys Ser Val Ile Gln Arg Thr Lys Arg Met Leu Asn Ala Leu Cys 
            340                 345                 350         


Pro His Lys Pro Ser Ala Lys Gln Val Ser Ser Glu Tyr Val Arg Asp 
        355                 360                 365             


Thr Lys Ile Glu Val Ala Gln Phe Leu Lys Asp Leu Leu Arg His Ser 
    370                 375                 380                 


Arg Ile Val Phe Arg Asn Glu Arg Phe Asn Ala Gly Ser Gly Phe Asn 
385                 390                 395                 400 


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
                405                 410                 415     


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
            420                 425                 430         


Ile Gly Ile Thr Glu Leu His His His His His His 
        435                 440                 


<210>  220
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-13 polyprotein.

<400>  220

Leu Thr Cys Leu Gly Gly Phe Ala Ser Pro Gly Pro Val Pro Pro Ser 
1               5                   10                  15      


Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn 
            20                  25                  30          


Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn Leu 
        35                  40                  45              


Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser 
    50                  55                  60                  


Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys 
65                  70                  75                  80  


Pro His Lys Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp 
                85                  90                  95      


Thr Lys Ile Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu 
            100                 105                 110         


Lys Lys Leu Phe Arg Glu Gly Arg Phe Asn Gly Ser Gly Gly Gln Tyr 
        115                 120                 125             


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser 
    130                 135                 140                 


Gly Leu Thr Cys Leu Gly Gly Phe Ala Ser Pro Gly Pro Val Pro Pro 
145                 150                 155                 160 


Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln 
                165                 170                 175     


Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn 
            180                 185                 190         


Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val 
        195                 200                 205             


Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe 
    210                 215                 220                 


Cys Pro His Lys Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg 
225                 230                 235                 240 


Asp Thr Lys Ile Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His 
                245                 250                 255     


Leu Lys Lys Leu Phe Arg Glu Gly Arg Phe Asn Ala Gly Ser Gly Phe 
            260                 265                 270         


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
        275                 280                 285             


Ser His Leu Glu Ser Gly Gly Ser Leu Thr Cys Leu Gly Gly Phe Ala 
    290                 295                 300                 


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
305                 310                 315                 320 


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
                325                 330                 335     


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
            340                 345                 350         


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
        355                 360                 365             


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
    370                 375                 380                 


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
385                 390                 395                 400 


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg 
                405                 410                 415     


Phe Asn Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu 
            420                 425                 430         


Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln 
        435                 440                 445             


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His 
    450                 455                 460                 


His His His His 
465             


<210>  221
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-33 Canonical isoform 
       (246 aa) polyprotein.

<400>  221

Met Lys Thr Lys Met Glu Tyr Ser Thr Thr Lys Ile Ser Pro Ala Lys 
1               5                   10                  15      


Met Asn Ser Ser Ala Gly Lys Ala Leu Val Lys Ser Pro Lys Leu Gly 
            20                  25                  30          


Lys Ser Gln Gln Lys Ala Glu Glu Val Cys Gln Met Tyr Phe Met Gln 
        35                  40                  45              


Leu Arg Ser Gly Leu Ile Lys Lys Thr Ala Cys Tyr Phe Lys Lys Glu 
    50                  55                  60                  


Thr Thr Lys Arg His Ser Thr Arg Arg Ala Gly Lys Tyr Lys Glu His 
65                  70                  75                  80  


Leu Val Phe Thr Ala Arg His Gln Gln Leu Glu Arg Pro Val Glu Gly 
                85                  90                  95      


Leu Ala Phe Gly Val Pro Met Val Gln Lys Cys Phe Gly Thr Thr Asp 
            100                 105                 110         


Val Pro Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp 
        115                 120                 125             


Gln Ser Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val 
    130                 135                 140                 


Glu Asp Leu Gly Lys Asp Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr 
145                 150                 155                 160 


Tyr Asp Phe Gln Ser Pro Ser Arg Glu Thr Gly Asp Ala Asp Asp Gly 
                165                 170                 175     


His Thr Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu 
            180                 185                 190         


Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu Gln Lys Cys Lys 
        195                 200                 205             


Lys Pro Leu Pro Asp Gln Ala Phe Phe Arg Leu His Arg Lys Ser Ser 
    210                 215                 220                 


Lys Cys Val Ser Phe Glu Cys Arg Pro Ala Pro Pro Phe Pro Pro Asp 
225                 230                 235                 240 


Leu Arg Ile Leu Gly Arg Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
                245                 250                 255     


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Met Lys Thr 
            260                 265                 270         


Lys Met Glu Tyr Ser Thr Thr Lys Ile Ser Pro Ala Lys Met Asn Ser 
        275                 280                 285             


Ser Ala Gly Lys Ala Leu Val Lys Ser Pro Lys Leu Gly Lys Ser Gln 
    290                 295                 300                 


Gln Lys Ala Glu Glu Val Cys Gln Met Tyr Phe Met Gln Leu Arg Ser 
305                 310                 315                 320 


Gly Leu Ile Lys Lys Thr Ala Cys Tyr Phe Lys Lys Glu Thr Thr Lys 
                325                 330                 335     


Arg His Ser Thr Arg Arg Ala Gly Lys Tyr Lys Glu His Leu Val Phe 
            340                 345                 350         


Thr Ala Arg His Gln Gln Leu Glu Arg Pro Val Glu Gly Leu Ala Phe 
        355                 360                 365             


Gly Val Pro Met Val Gln Lys Cys Phe Gly Thr Thr Asp Val Pro Ser 
    370                 375                 380                 


Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile 
385                 390                 395                 400 


Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu Asp Leu 
                405                 410                 415     


Gly Lys Asp Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr Tyr Asp Phe 
            420                 425                 430         


Gln Ser Pro Ser Arg Glu Thr Gly Asp Ala Asp Asp Gly His Thr Leu 
        435                 440                 445             


Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu His Ala 
    450                 455                 460                 


Asn Asn Lys Glu His Ser Val Glu Leu Gln Lys Cys Lys Lys Pro Leu 
465                 470                 475                 480 


Pro Asp Gln Ala Phe Phe Arg Leu His Arg Lys Ser Ser Lys Cys Val 
                485                 490                 495     


Ser Phe Glu Cys Arg Pro Ala Pro Pro Phe Pro Pro Asp Leu Arg Ile 
            500                 505                 510         


Leu Gly Arg Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
        515                 520                 525             


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
    530                 535                 540                 


Met Lys Thr Lys Met Glu Tyr Ser Thr Thr Lys Ile Ser Pro Ala Lys 
545                 550                 555                 560 


Met Asn Ser Ser Ala Gly Lys Ala Leu Val Lys Ser Pro Lys Leu Gly 
                565                 570                 575     


Lys Ser Gln Gln Lys Ala Glu Glu Val Cys Gln Met Tyr Phe Met Gln 
            580                 585                 590         


Leu Arg Ser Gly Leu Ile Lys Lys Thr Ala Cys Tyr Phe Lys Lys Glu 
        595                 600                 605             


Thr Thr Lys Arg His Ser Thr Arg Arg Ala Gly Lys Tyr Lys Glu His 
    610                 615                 620                 


Leu Val Phe Thr Ala Arg His Gln Gln Leu Glu Arg Pro Val Glu Gly 
625                 630                 635                 640 


Leu Ala Phe Gly Val Pro Met Val Gln Lys Cys Phe Gly Thr Thr Asp 
                645                 650                 655     


Val Pro Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp 
            660                 665                 670         


Gln Ser Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val 
        675                 680                 685             


Glu Asp Leu Gly Lys Asp Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr 
    690                 695                 700                 


Tyr Asp Phe Gln Ser Pro Ser Arg Glu Thr Gly Asp Ala Asp Asp Gly 
705                 710                 715                 720 


His Thr Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu 
                725                 730                 735     


Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu Gln Lys Cys Lys 
            740                 745                 750         


Lys Pro Leu Pro Asp Gln Ala Phe Phe Arg Leu His Arg Lys Ser Ser 
        755                 760                 765             


Lys Cys Val Ser Phe Glu Cys Arg Pro Ala Pro Pro Phe Pro Pro Asp 
    770                 775                 780                 


Leu Arg Ile Leu Gly Arg Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
785                 790                 795                 800 


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
                805                 810                 815     


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
            820                 825                 830         


Glu Leu His His His His His His 
        835                 840 


<210>  222
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-33 Other isoform (268 
       aa) polyprotein.

<400>  222

Met Lys Thr Lys Met Glu Tyr Ser Thr Thr Lys Ile Ser Pro Ala Lys 
1               5                   10                  15      


Met Asn Ser Ser Ala Gly Lys Ala Leu Val Lys Ser Pro Lys Leu Gly 
            20                  25                  30          


Lys Ser Gln Gln Lys Ala Glu Glu Val Cys Gln Met Tyr Phe Met Gln 
        35                  40                  45              


Leu Arg Ser Gly Leu Ile Lys Lys Thr Ala Cys Tyr Phe Lys Lys Glu 
    50                  55                  60                  


Thr Thr Lys Arg His Ser Thr Arg Arg Ala Gly Lys Tyr Lys Glu His 
65                  70                  75                  80  


Leu Val Phe Thr Ala Arg His Gln Gln Leu Glu Arg Pro Val Glu Gly 
                85                  90                  95      


Leu Ala Phe Gly Val Pro Met Val Gln Lys Cys Phe Gly Thr Thr Asp 
            100                 105                 110         


Val Pro Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp 
        115                 120                 125             


Gln Ser Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val 
    130                 135                 140                 


Glu Asp Leu Gly Lys Asp Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr 
145                 150                 155                 160 


Tyr Asp Phe Gln Ser Pro Ser Arg Glu Thr Gly Asp Ala Asp Asp Gly 
                165                 170                 175     


His Thr Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu 
            180                 185                 190         


Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu Gln Lys Cys Lys 
        195                 200                 205             


Lys Pro Leu Pro Asp Gln Ala Phe Phe Arg Leu His Arg Lys Ser Ser 
    210                 215                 220                 


Lys Cys Val Ser Phe Glu Cys Lys Asn Asp Pro Gly Val Phe Ile Gly 
225                 230                 235                 240 


Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Glu Asp Gln Thr Glu 
                245                 250                 255     


Tyr Phe Ser Thr Glu Asn Ile Ile Phe Lys Leu Ser Gly Ser Gly Gly 
            260                 265                 270         


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala 
        275                 280                 285             


Gly Ser Gly Met Lys Thr Lys Met Glu Tyr Ser Thr Thr Lys Ile Ser 
    290                 295                 300                 


Pro Ala Lys Met Asn Ser Ser Ala Gly Lys Ala Leu Val Lys Ser Pro 
305                 310                 315                 320 


Lys Leu Gly Lys Ser Gln Gln Lys Ala Glu Glu Val Cys Gln Met Tyr 
                325                 330                 335     


Phe Met Gln Leu Arg Ser Gly Leu Ile Lys Lys Thr Ala Cys Tyr Phe 
            340                 345                 350         


Lys Lys Glu Thr Thr Lys Arg His Ser Thr Arg Arg Ala Gly Lys Tyr 
        355                 360                 365             


Lys Glu His Leu Val Phe Thr Ala Arg His Gln Gln Leu Glu Arg Pro 
    370                 375                 380                 


Val Glu Gly Leu Ala Phe Gly Val Pro Met Val Gln Lys Cys Phe Gly 
385                 390                 395                 400 


Thr Thr Asp Val Pro Ser Ile Gln Glu Tyr Ser Ala Ser Leu Ser Thr 
                405                 410                 415     


Tyr Asn Asp Gln Ser Ile Thr Phe Val Phe Glu Asp Gly Ser Tyr Glu 
            420                 425                 430         


Ile Tyr Val Glu Asp Leu Gly Lys Asp Gln Glu Lys Asp Lys Val Leu 
        435                 440                 445             


Phe Arg Tyr Tyr Asp Phe Gln Ser Pro Ser Arg Glu Thr Gly Asp Ala 
    450                 455                 460                 


Asp Asp Gly His Thr Leu Leu Val Asn Leu Ser Pro Thr Lys Asp Lys 
465                 470                 475                 480 


Asp Phe Leu Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu Gln 
                485                 490                 495     


Lys Cys Lys Lys Pro Leu Pro Asp Gln Ala Phe Phe Arg Leu His Arg 
            500                 505                 510         


Lys Ser Ser Lys Cys Val Ser Phe Glu Cys Lys Asn Asp Pro Gly Val 
        515                 520                 525             


Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Glu Asp 
    530                 535                 540                 


Gln Thr Glu Tyr Phe Ser Thr Glu Asn Ile Ile Phe Lys Leu Ser Ala 
545                 550                 555                 560 


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
                565                 570                 575     


Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Met Lys Thr Lys 
            580                 585                 590         


Met Glu Tyr Ser Thr Thr Lys Ile Ser Pro Ala Lys Met Asn Ser Ser 
        595                 600                 605             


Ala Gly Lys Ala Leu Val Lys Ser Pro Lys Leu Gly Lys Ser Gln Gln 
    610                 615                 620                 


Lys Ala Glu Glu Val Cys Gln Met Tyr Phe Met Gln Leu Arg Ser Gly 
625                 630                 635                 640 


Leu Ile Lys Lys Thr Ala Cys Tyr Phe Lys Lys Glu Thr Thr Lys Arg 
                645                 650                 655     


His Ser Thr Arg Arg Ala Gly Lys Tyr Lys Glu His Leu Val Phe Thr 
            660                 665                 670         


Ala Arg His Gln Gln Leu Glu Arg Pro Val Glu Gly Leu Ala Phe Gly 
        675                 680                 685             


Val Pro Met Val Gln Lys Cys Phe Gly Thr Thr Asp Val Pro Ser Ile 
    690                 695                 700                 


Gln Glu Tyr Ser Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr 
705                 710                 715                 720 


Phe Val Phe Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu Asp Leu Gly 
                725                 730                 735     


Lys Asp Gln Glu Lys Asp Lys Val Leu Phe Arg Tyr Tyr Asp Phe Gln 
            740                 745                 750         


Ser Pro Ser Arg Glu Thr Gly Asp Ala Asp Asp Gly His Thr Leu Leu 
        755                 760                 765             


Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu His Ala Asn 
    770                 775                 780                 


Asn Lys Glu His Ser Val Glu Leu Gln Lys Cys Lys Lys Pro Leu Pro 
785                 790                 795                 800 


Asp Gln Ala Phe Phe Arg Leu His Arg Lys Ser Ser Lys Cys Val Ser 
                805                 810                 815     


Phe Glu Cys Lys Asn Asp Pro Gly Val Phe Ile Gly Val Lys Asp Asn 
            820                 825                 830         


His Leu Ala Leu Ile Lys Val Glu Asp Gln Thr Glu Tyr Phe Ser Thr 
        835                 840                 845             


Glu Asn Ile Ile Phe Lys Leu Ser Ala Gly Ser Gly Phe Asn Asn Phe 
    850                 855                 860                 


Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu 
865                 870                 875                 880 


Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
                885                 890                 895     


Ile Thr Glu Leu His His His His His His 
            900                 905     


<210>  223
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of pig IL-33 polyprotein.

<400>  223

Lys Pro Glu Val Lys Tyr Ser Thr Thr Lys Ile Ser Thr Ala Lys Met 
1               5                   10                  15      


Asn Ser Ser Ala Gly Lys Val Ser Ile Lys Ser Pro Lys Leu Arg Asn 
            20                  25                  30          


Lys Val Leu Leu Arg Tyr Tyr Asp Ser Gln Ile Pro Ser Ser Glu Thr 
        35                  40                  45              


Asp Gly Gly Gly Asp His Arg Lys Leu Met Val Asn Leu Ser Pro Thr 
    50                  55                  60                  


Lys Asp Lys Asp Phe Leu Leu His Ala Asn Ser Lys Glu His Ser Val 
65                  70                  75                  80  


Glu Leu Gln Lys Cys Glu Asn Pro Leu Pro Glu Gln Ala Phe Phe Val 
                85                  90                  95      


Leu His Glu Gln Pro Ser Lys Cys Val Ser Phe Glu Cys Lys Ser His 
            100                 105                 110         


Pro Gly Val Phe Leu Gly Val Lys Asn Asn Gln Leu Ala Leu Ile Lys 
        115                 120                 125             


Leu Gly Glu His Pro Glu Asp Ser Asn Arg Glu Asn Thr Thr Phe Lys 
    130                 135                 140                 


Leu Thr Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
145                 150                 155                 160 


Gly Ile Thr Glu Leu Ala Gly Ser Gly Lys Pro Glu Val Lys Tyr Ser 
                165                 170                 175     


Thr Thr Lys Ile Ser Thr Ala Lys Met Asn Ser Ser Ala Gly Lys Val 
            180                 185                 190         


Ser Ile Lys Ser Pro Lys Leu Arg Asn Lys Val Leu Leu Arg Tyr Tyr 
        195                 200                 205             


Asp Ser Gln Ile Pro Ser Ser Glu Thr Asp Gly Gly Gly Asp His Arg 
    210                 215                 220                 


Lys Leu Met Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu 
225                 230                 235                 240 


His Ala Asn Ser Lys Glu His Ser Val Glu Leu Gln Lys Cys Glu Asn 
                245                 250                 255     


Pro Leu Pro Glu Gln Ala Phe Phe Val Leu His Glu Gln Pro Ser Lys 
            260                 265                 270         


Cys Val Ser Phe Glu Cys Lys Ser His Pro Gly Val Phe Leu Gly Val 
        275                 280                 285             


Lys Asn Asn Gln Leu Ala Leu Ile Lys Leu Gly Glu His Pro Glu Asp 
    290                 295                 300                 


Ser Asn Arg Glu Asn Thr Thr Phe Lys Leu Thr Ala Gly Ser Gly Phe 
305                 310                 315                 320 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
                325                 330                 335     


Ser His Leu Glu Ser Gly Gly Ser Lys Pro Glu Val Lys Tyr Ser Thr 
            340                 345                 350         


Thr Lys Ile Ser Thr Ala Lys Met Asn Ser Ser Ala Gly Lys Val Ser 
        355                 360                 365             


Ile Lys Ser Pro Lys Leu Arg Asn Lys Val Leu Leu Arg Tyr Tyr Asp 
    370                 375                 380                 


Ser Gln Ile Pro Ser Ser Glu Thr Asp Gly Gly Gly Asp His Arg Lys 
385                 390                 395                 400 


Leu Met Val Asn Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu His 
                405                 410                 415     


Ala Asn Ser Lys Glu His Ser Val Glu Leu Gln Lys Cys Glu Asn Pro 
            420                 425                 430         


Leu Pro Glu Gln Ala Phe Phe Val Leu His Glu Gln Pro Ser Lys Cys 
        435                 440                 445             


Val Ser Phe Glu Cys Lys Ser His Pro Gly Val Phe Leu Gly Val Lys 
    450                 455                 460                 


Asn Asn Gln Leu Ala Leu Ile Lys Leu Gly Glu His Pro Glu Asp Ser 
465                 470                 475                 480 


Asn Arg Glu Asn Thr Thr Phe Lys Leu Thr Ala Gly Ser Gly Phe Asn 
                485                 490                 495     


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
            500                 505                 510         


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
        515                 520                 525             


Ile Gly Ile Thr Glu Leu His His His His His His 
    530                 535                 540 


<210>  224
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine IL-33 polyprotein.

<400>  224

Met Lys Pro Lys Met Lys Tyr Ser Thr Thr Lys Ile Ser Pro Ala Lys 
1               5                   10                  15      


Met Lys Cys Ser Ala Gly Lys Ala Leu Val Lys Ser Pro Lys Leu Arg 
            20                  25                  30          


Lys Ser Gln Gln Lys Ala Glu Glu Val Cys Gln Ile Tyr Tyr Met Gln 
        35                  40                  45              


Leu Arg Ser Gly Leu Lys Ile Glu Lys Lys Val Cys Tyr Phe Arg Lys 
    50                  55                  60                  


Glu Thr Thr Lys Arg His Ser Leu Thr Ala Glu Lys Tyr Lys Glu His 
65                  70                  75                  80  


Leu Ala Leu Val Ala Cys Glu Gln Leu Asn His Leu Gln Gln Ser Val 
                85                  90                  95      


Glu Gln Gly Phe Thr Leu Gly Lys Thr Met Val Pro Tyr Thr Thr Ala 
            100                 105                 110         


Thr Gly Leu Pro Ser Ile Lys Glu His Ser Ala Ser Leu Ser Thr Tyr 
        115                 120                 125             


Asn Asp Gln Phe Ile Thr Phe Val Leu Glu Asp Gly Ser Tyr Glu Ile 
    130                 135                 140                 


Tyr Val Glu Asp Leu Ile Asp Asn Gln Glu Lys Asp Lys Val Leu Leu 
145                 150                 155                 160 


Arg Tyr Tyr Asp Ser Gln Phe Pro Ser Ser Glu Thr Asp Asp Gly Gly 
                165                 170                 175     


Ser His Arg Lys Leu Met Val Asn Leu Ser Pro Thr Lys Asp Lys Asp 
            180                 185                 190         


Phe Leu Leu His Ala Asn Ser Lys Glu His Ser Val Glu Leu Gln Lys 
        195                 200                 205             


Cys Glu Asn Gln Leu Pro Glu Gln Thr Phe Phe Val Leu His Glu Thr 
    210                 215                 220                 


Ser Ser Gln Cys Val Ser Phe Glu Cys Lys Ser Asn Pro Gly Val Phe 
225                 230                 235                 240 


Leu Gly Val Lys Asp Asn Gln Leu Ala Leu Ile Lys Arg Gly Glu His 
                245                 250                 255     


Pro Glu Asp Ser Asn Ser Gln Asn Ile Thr Phe Lys Leu Ser Asn Leu 
            260                 265                 270         


Met Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
        275                 280                 285             


Ile Thr Glu Leu Ala Gly Ser Gly Met Lys Pro Lys Met Lys Tyr Ser 
    290                 295                 300                 


Thr Thr Lys Ile Ser Pro Ala Lys Met Lys Cys Ser Ala Gly Lys Ala 
305                 310                 315                 320 


Leu Val Lys Ser Pro Lys Leu Arg Lys Ser Gln Gln Lys Ala Glu Glu 
                325                 330                 335     


Val Cys Gln Ile Tyr Tyr Met Gln Leu Arg Ser Gly Leu Lys Ile Glu 
            340                 345                 350         


Lys Lys Val Cys Tyr Phe Arg Lys Glu Thr Thr Lys Arg His Ser Leu 
        355                 360                 365             


Thr Ala Glu Lys Tyr Lys Glu His Leu Ala Leu Val Ala Cys Glu Gln 
    370                 375                 380                 


Leu Asn His Leu Gln Gln Ser Val Glu Gln Gly Phe Thr Leu Gly Lys 
385                 390                 395                 400 


Thr Met Val Pro Tyr Thr Thr Ala Thr Gly Leu Pro Ser Ile Lys Glu 
                405                 410                 415     


His Ser Ala Ser Leu Ser Thr Tyr Asn Asp Gln Phe Ile Thr Phe Val 
            420                 425                 430         


Leu Glu Asp Gly Ser Tyr Glu Ile Tyr Val Glu Asp Leu Ile Asp Asn 
        435                 440                 445             


Gln Glu Lys Asp Lys Val Leu Leu Arg Tyr Tyr Asp Ser Gln Phe Pro 
    450                 455                 460                 


Ser Ser Glu Thr Asp Asp Gly Gly Ser His Arg Lys Leu Met Val Asn 
465                 470                 475                 480 


Leu Ser Pro Thr Lys Asp Lys Asp Phe Leu Leu His Ala Asn Ser Lys 
                485                 490                 495     


Glu His Ser Val Glu Leu Gln Lys Cys Glu Asn Gln Leu Pro Glu Gln 
            500                 505                 510         


Thr Phe Phe Val Leu His Glu Thr Ser Ser Gln Cys Val Ser Phe Glu 
        515                 520                 525             


Cys Lys Ser Asn Pro Gly Val Phe Leu Gly Val Lys Asp Asn Gln Leu 
    530                 535                 540                 


Ala Leu Ile Lys Arg Gly Glu His Pro Glu Asp Ser Asn Ser Gln Asn 
545                 550                 555                 560 


Ile Thr Phe Lys Leu Ser Asn Leu Met Ala Gly Ser Gly Phe Asn Asn 
                565                 570                 575     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            580                 585                 590         


Leu Glu Ser Gly Gly Ser Met Lys Pro Lys Met Lys Tyr Ser Thr Thr 
        595                 600                 605             


Lys Ile Ser Pro Ala Lys Met Lys Cys Ser Ala Gly Lys Ala Leu Val 
    610                 615                 620                 


Lys Ser Pro Lys Leu Arg Lys Ser Gln Gln Lys Ala Glu Glu Val Cys 
625                 630                 635                 640 


Gln Ile Tyr Tyr Met Gln Leu Arg Ser Gly Leu Lys Ile Glu Lys Lys 
                645                 650                 655     


Val Cys Tyr Phe Arg Lys Glu Thr Thr Lys Arg His Ser Leu Thr Ala 
            660                 665                 670         


Glu Lys Tyr Lys Glu His Leu Ala Leu Val Ala Cys Glu Gln Leu Asn 
        675                 680                 685             


His Leu Gln Gln Ser Val Glu Gln Gly Phe Thr Leu Gly Lys Thr Met 
    690                 695                 700                 


Val Pro Tyr Thr Thr Ala Thr Gly Leu Pro Ser Ile Lys Glu His Ser 
705                 710                 715                 720 


Ala Ser Leu Ser Thr Tyr Asn Asp Gln Phe Ile Thr Phe Val Leu Glu 
                725                 730                 735     


Asp Gly Ser Tyr Glu Ile Tyr Val Glu Asp Leu Ile Asp Asn Gln Glu 
            740                 745                 750         


Lys Asp Lys Val Leu Leu Arg Tyr Tyr Asp Ser Gln Phe Pro Ser Ser 
        755                 760                 765             


Glu Thr Asp Asp Gly Gly Ser His Arg Lys Leu Met Val Asn Leu Ser 
    770                 775                 780                 


Pro Thr Lys Asp Lys Asp Phe Leu Leu His Ala Asn Ser Lys Glu His 
785                 790                 795                 800 


Ser Val Glu Leu Gln Lys Cys Glu Asn Gln Leu Pro Glu Gln Thr Phe 
                805                 810                 815     


Phe Val Leu His Glu Thr Ser Ser Gln Cys Val Ser Phe Glu Cys Lys 
            820                 825                 830         


Ser Asn Pro Gly Val Phe Leu Gly Val Lys Asp Asn Gln Leu Ala Leu 
        835                 840                 845             


Ile Lys Arg Gly Glu His Pro Glu Asp Ser Asn Ser Gln Asn Ile Thr 
    850                 855                 860                 


Phe Lys Leu Ser Asn Leu Met Ala Gly Ser Gly Phe Asn Asn Phe Thr 
865                 870                 875                 880 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
                885                 890                 895     


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
            900                 905                 910         


Thr Glu Leu His His His His His His 
        915                 920     


<210>  225
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-33 Full length 
       (1-270) polyprotein.

<400>  225

Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      


Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser 
            20                  25                  30          


Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg 
        35                  40                  45              


Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr 
    50                  55                  60                  


Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu 
65                  70                  75                  80  


Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe 
                85                  90                  95      


Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser 
            100                 105                 110         


Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr 
        115                 120                 125             


Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu 
    130                 135                 140                 


Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu 
145                 150                 155                 160 


Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly 
                165                 170                 175     


Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe 
            180                 185                 190         


Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys 
        195                 200                 205             


Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His 
    210                 215                 220                 


Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile 
225                 230                 235                 240 


Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu 
                245                 250                 255     


Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr Gly Ser 
            260                 265                 270         


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
        275                 280                 285             


Leu Ala Gly Ser Gly Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys 
    290                 295                 300                 


Ile Ser Thr Ala Lys Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe 
305                 310                 315                 320 


Lys Leu Gly Lys Ser Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr 
                325                 330                 335     


Phe Met Lys Leu Arg Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr 
            340                 345                 350         


Phe Arg Arg Glu Thr Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys 
        355                 360                 365             


His Lys Arg His Leu Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val 
    370                 375                 380                 


Glu Cys Phe Ala Phe Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala 
385                 390                 395                 400 


Leu His Asp Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu 
                405                 410                 415     


Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu 
            420                 425                 430         


Asp Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys 
        435                 440                 445             


Lys Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn 
    450                 455                 460                 


Glu Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser 
465                 470                 475                 480 


Pro Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val 
                485                 490                 495     


Glu Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val 
            500                 505                 510         


Leu His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp 
        515                 520                 525             


Pro Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys 
    530                 535                 540                 


Val Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu 
545                 550                 555                 560 


Ser Glu Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
                565                 570                 575     


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
            580                 585                 590         


Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys 
        595                 600                 605             


Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser 
    610                 615                 620                 


Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg 
625                 630                 635                 640 


Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr 
                645                 650                 655     


Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu 
            660                 665                 670         


Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe 
        675                 680                 685             


Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser 
    690                 695                 700                 


Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr 
705                 710                 715                 720 


Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu 
                725                 730                 735     


Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu 
            740                 745                 750         


Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly 
        755                 760                 765             


Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe 
    770                 775                 780                 


Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys 
785                 790                 795                 800 


Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His 
                805                 810                 815     


Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile 
            820                 825                 830         


Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu 
        835                 840                 845             


Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr Ala Gly 
    850                 855                 860                 


Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
865                 870                 875                 880 


Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
                885                 890                 895     


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
            900                 905                 910         


<210>  226
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-33 Chain 1 (95-270) 
       polyprotein.

<400>  226

Ala Phe Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp 
1               5                   10                  15      


Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu 
            20                  25                  30          


Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser 
        35                  40                  45              


Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys 
    50                  55                  60                  


Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly 
65                  70                  75                  80  


Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys 
                85                  90                  95      


Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His 
            100                 105                 110         


Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn 
        115                 120                 125             


Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val 
    130                 135                 140                 


Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser 
145                 150                 155                 160 


Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
                165                 170                 175     


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
            180                 185                 190         


Thr Glu Leu Ala Gly Ser Gly Ala Phe Gly Ile Ser Gly Val Gln Lys 
        195                 200                 205             


Tyr Thr Arg Ala Leu His Asp Ser Ser Ile Thr Gly Ile Ser Pro Ile 
    210                 215                 220                 


Thr Glu Tyr Leu Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr 
225                 230                 235                 240 


Phe Ala Leu Glu Asp Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys 
                245                 250                 255     


Lys Asp Glu Lys Lys Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln 
            260                 265                 270         


His Pro Ser Asn Glu Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met 
        275                 280                 285             


Val Thr Leu Ser Pro Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys 
    290                 295                 300                 


Glu His Ser Val Glu Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln 
305                 310                 315                 320 


Ala Phe Phe Val Leu His Asn Met His Ser Asn Cys Val Ser Phe Glu 
                325                 330                 335     


Cys Lys Thr Asp Pro Gly Val Phe Ile Gly Val Lys Asp Asn His Leu 
            340                 345                 350         


Ala Leu Ile Lys Val Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile 
        355                 360                 365             


Leu Phe Lys Leu Ser Glu Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr 
    370                 375                 380                 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
385                 390                 395                 400 


Ser Gly Gly Ser Ala Phe Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg 
                405                 410                 415     


Ala Leu His Asp Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr 
            420                 425                 430         


Leu Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu 
        435                 440                 445             


Glu Asp Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu 
    450                 455                 460                 


Lys Lys Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser 
465                 470                 475                 480 


Asn Glu Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu 
                485                 490                 495     


Ser Pro Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser 
            500                 505                 510         


Val Glu Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe 
        515                 520                 525             


Val Leu His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr 
    530                 535                 540                 


Asp Pro Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile 
545                 550                 555                 560 


Lys Val Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys 
                565                 570                 575     


Leu Ser Glu Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
            580                 585                 590         


Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly 
        595                 600                 605             


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
    610                 615                 620                 


His His His His His His 
625                 630 


<210>  227
<211>  618
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-33 Chain 2 (99-270) 
       polyprotein.

<400>  227

Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser Ile Thr 
1               5                   10                  15      


Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr Tyr Asn 
            20                  25                  30          


Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu Ile Tyr 
        35                  40                  45              


Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu Leu Ser 
    50                  55                  60                  


Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly Val Asp 
65                  70                  75                  80  


Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe Trp Leu 
                85                  90                  95      


His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys Glu Lys 
            100                 105                 110         


Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His Ser Asn 
        115                 120                 125             


Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile Gly Val 
    130                 135                 140                 


Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu Asn Leu 
145                 150                 155                 160 


Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr Gly Ser Gly Gly 
                165                 170                 175     


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala 
            180                 185                 190         


Gly Ser Gly Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser 
        195                 200                 205             


Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser 
    210                 215                 220                 


Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr 
225                 230                 235                 240 


Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val 
                245                 250                 255     


Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp 
            260                 265                 270         


Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp 
        275                 280                 285             


Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys 
    290                 295                 300                 


Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met 
305                 310                 315                 320 


His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe 
                325                 330                 335     


Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser 
            340                 345                 350         


Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr Ala 
        355                 360                 365             


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
    370                 375                 380                 


Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Ser Gly Val Gln 
385                 390                 395                 400 


Lys Tyr Thr Arg Ala Leu His Asp Ser Ser Ile Thr Gly Ile Ser Pro 
                405                 410                 415     


Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile 
            420                 425                 430         


Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu 
        435                 440                 445             


Lys Lys Asp Glu Lys Lys Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser 
    450                 455                 460                 


Gln His Pro Ser Asn Glu Ser Gly Asp Gly Val Asp Gly Lys Met Leu 
465                 470                 475                 480 


Met Val Thr Leu Ser Pro Thr Lys Asp Phe Trp Leu His Ala Asn Asn 
                485                 490                 495     


Lys Glu His Ser Val Glu Leu His Lys Cys Glu Lys Pro Leu Pro Asp 
            500                 505                 510         


Gln Ala Phe Phe Val Leu His Asn Met His Ser Asn Cys Val Ser Phe 
        515                 520                 525             


Glu Cys Lys Thr Asp Pro Gly Val Phe Ile Gly Val Lys Asp Asn His 
    530                 535                 540                 


Leu Ala Leu Ile Lys Val Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn 
545                 550                 555                 560 


Ile Leu Phe Lys Leu Ser Glu Thr Ala Gly Ser Gly Phe Asn Asn Phe 
                565                 570                 575     


Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu 
            580                 585                 590         


Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
        595                 600                 605             


Ile Thr Glu Leu His His His His His His 
    610                 615             


<210>  228
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-33 Chain 3 (109-270) 
       polyprotein.

<400>  228

His Asp Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala 
1               5                   10                  15      


Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp 
            20                  25                  30          


Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys 
        35                  40                  45              


Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu 
    50                  55                  60                  


Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro 
65                  70                  75                  80  


Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu 
                85                  90                  95      


Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu 
            100                 105                 110         


His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro 
        115                 120                 125             


Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val 
    130                 135                 140                 


Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser 
145                 150                 155                 160 


Glu Thr Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
                165                 170                 175     


Gly Ile Thr Glu Leu Ala Gly Ser Gly His Asp Ser Ser Ile Thr Gly 
            180                 185                 190         


Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr Tyr Asn Asp 
        195                 200                 205             


Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu Ile Tyr Val 
    210                 215                 220                 


Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu Leu Ser Tyr 
225                 230                 235                 240 


Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly Val Asp Gly 
                245                 250                 255     


Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe Trp Leu His 
            260                 265                 270         


Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys Glu Lys Pro 
        275                 280                 285             


Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His Ser Asn Cys 
    290                 295                 300                 


Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile Gly Val Lys 
305                 310                 315                 320 


Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu Asn Leu Cys 
                325                 330                 335     


Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr Ala Gly Ser Gly Phe 
            340                 345                 350         


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
        355                 360                 365             


Ser His Leu Glu Ser Gly Gly Ser His Asp Ser Ser Ile Thr Gly Ile 
    370                 375                 380                 


Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr Tyr Asn Asp Gln 
385                 390                 395                 400 


Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu Ile Tyr Val Glu 
                405                 410                 415     


Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu Leu Ser Tyr Tyr 
            420                 425                 430         


Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly Val Asp Gly Lys 
        435                 440                 445             


Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe Trp Leu His Ala 
    450                 455                 460                 


Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys Glu Lys Pro Leu 
465                 470                 475                 480 


Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His Ser Asn Cys Val 
                485                 490                 495     


Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile Gly Val Lys Asp 
            500                 505                 510         


Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu Asn Leu Cys Thr 
        515                 520                 525             


Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr Ala Gly Ser Gly Phe Asn 
    530                 535                 540                 


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
545                 550                 555                 560 


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
                565                 570                 575     


Ile Gly Ile Thr Glu Leu His His His His His His 
            580                 585             


<210>  229
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of canine TNF-alpha polyprotein.

<400>  229

Val Lys Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Glu Ala Glu Gly Gln Leu Gln Trp Leu Ser Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Thr Asp Asn Gln Leu 
        35                  40                  45              


Ile Val Pro Ser Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Phe Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Thr Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Leu Pro Asn Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Ser Gly 
145                 150                 155                 160 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                165                 170                 175     


Ala Gly Ser Gly Val Lys Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro 
            180                 185                 190         


Val Ala His Val Val Ala Asn Pro Glu Ala Glu Gly Gln Leu Gln Trp 
        195                 200                 205             


Leu Ser Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Thr 
    210                 215                 220                 


Asp Asn Gln Leu Ile Val Pro Ser Asp Gly Leu Tyr Leu Ile Tyr Ser 
225                 230                 235                 240 


Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu 
                245                 250                 255     


Thr His Thr Ile Ser Arg Phe Ala Val Ser Tyr Gln Thr Lys Val Asn 
            260                 265                 270         


Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly 
        275                 280                 285             


Thr Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe 
    290                 295                 300                 


Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Leu Pro Asn 
305                 310                 315                 320 


Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala 
                325                 330                 335     


Leu Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
            340                 345                 350         


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Val Lys 
        355                 360                 365             


Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala 
    370                 375                 380                 


Asn Pro Glu Ala Glu Gly Gln Leu Gln Trp Leu Ser Arg Arg Ala Asn 
385                 390                 395                 400 


Ala Leu Leu Ala Asn Gly Val Glu Leu Thr Asp Asn Gln Leu Ile Val 
                405                 410                 415     


Pro Ser Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly 
            420                 425                 430         


Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg 
        435                 440                 445             


Phe Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys 
    450                 455                 460                 


Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Thr Glu Ala Lys Pro Trp 
465                 470                 475                 480 


Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp 
                485                 490                 495     


Arg Leu Ser Ala Glu Ile Asn Leu Pro Asn Tyr Leu Asp Phe Ala Glu 
            500                 505                 510         


Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Ala Gly Ser Gly Phe 
        515                 520                 525             


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
    530                 535                 540                 


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
545                 550                 555                 560 


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
                565                 570             


<210>  230
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of feline TNF-alpha polyprotein.

<400>  230

Leu Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Glu Ala Glu Gly Gln Leu Gln Trp Leu Ser Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Thr Asp Asn Gln Leu 
        35                  40                  45              


Lys Val Pro Ser Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Thr Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Phe Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Thr Glu Ile Asn Leu Pro Ala Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Ser Gly 
145                 150                 155                 160 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                165                 170                 175     


Ala Gly Ser Gly Leu Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro 
            180                 185                 190         


Val Ala His Val Val Ala Asn Pro Glu Ala Glu Gly Gln Leu Gln Trp 
        195                 200                 205             


Leu Ser Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Thr 
    210                 215                 220                 


Asp Asn Gln Leu Lys Val Pro Ser Asp Gly Leu Tyr Leu Ile Tyr Ser 
225                 230                 235                 240 


Gln Val Leu Phe Thr Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu 
                245                 250                 255     


Thr His Thr Ile Ser Arg Phe Ala Val Ser Tyr Gln Thr Lys Val Asn 
            260                 265                 270         


Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly 
        275                 280                 285             


Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe 
    290                 295                 300                 


Gln Leu Glu Lys Gly Asp Arg Leu Ser Thr Glu Ile Asn Leu Pro Ala 
305                 310                 315                 320 


Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala 
                325                 330                 335     


Leu Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
            340                 345                 350         


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Leu Arg 
        355                 360                 365             


Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala 
    370                 375                 380                 


Asn Pro Glu Ala Glu Gly Gln Leu Gln Trp Leu Ser Arg Arg Ala Asn 
385                 390                 395                 400 


Ala Leu Leu Ala Asn Gly Val Glu Leu Thr Asp Asn Gln Leu Lys Val 
                405                 410                 415     


Pro Ser Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Thr Gly 
            420                 425                 430         


Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg 
        435                 440                 445             


Phe Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys 
    450                 455                 460                 


Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp 
465                 470                 475                 480 


Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp 
                485                 490                 495     


Arg Leu Ser Thr Glu Ile Asn Leu Pro Ala Tyr Leu Asp Phe Ala Glu 
            500                 505                 510         


Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Ala Gly Ser Gly Phe 
        515                 520                 525             


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
    530                 535                 540                 


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
545                 550                 555                 560 


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
                565                 570             


<210>  231
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine IL1-beta polyprotein.

<400>  231

Ala Pro Val Gln Ser Ile Lys Cys Lys Leu Gln Asp Arg Glu Gln Lys 
1               5                   10                  15      


Ser Leu Val Leu Ala Ser Pro Cys Val Leu Lys Ala Leu His Leu Leu 
            20                  25                  30          


Ser Gln Glu Met Asn Arg Glu Val Val Phe Cys Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Arg Asp Asn Lys Ile Pro Val Ala Leu Gly Ile Lys Asp 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Lys Lys Gly Asp Thr Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Glu Val Asp Pro Lys Val Tyr Pro Lys Arg Asn Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Tyr Lys Thr Glu Ile Lys Asn Thr Val Glu Phe 
            100                 105                 110         


Glu Ser Val Leu Tyr Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ile Glu 
        115                 120                 125             


Glu Arg Pro Val Phe Leu Gly His Phe Arg Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Arg Met Glu Thr Leu Ser Pro Gly Ser Gly Gly Gln Tyr Ile 
145                 150                 155                 160 


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly 
                165                 170                 175     


Ala Pro Val Gln Ser Ile Lys Cys Lys Leu Gln Asp Arg Glu Gln Lys 
            180                 185                 190         


Ser Leu Val Leu Ala Ser Pro Cys Val Leu Lys Ala Leu His Leu Leu 
        195                 200                 205             


Ser Gln Glu Met Asn Arg Glu Val Val Phe Cys Met Ser Phe Val Gln 
    210                 215                 220                 


Gly Glu Glu Arg Asp Asn Lys Ile Pro Val Ala Leu Gly Ile Lys Asp 
225                 230                 235                 240 


Lys Asn Leu Tyr Leu Ser Cys Val Lys Lys Gly Asp Thr Pro Thr Leu 
                245                 250                 255     


Gln Leu Glu Glu Val Asp Pro Lys Val Tyr Pro Lys Arg Asn Met Glu 
            260                 265                 270         


Lys Arg Phe Val Phe Tyr Lys Thr Glu Ile Lys Asn Thr Val Glu Phe 
        275                 280                 285             


Glu Ser Val Leu Tyr Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ile Glu 
    290                 295                 300                 


Glu Arg Pro Val Phe Leu Gly His Phe Arg Gly Gly Gln Asp Ile Thr 
305                 310                 315                 320 


Asp Phe Arg Met Glu Thr Leu Ser Pro Ala Gly Ser Gly Phe Asn Asn 
                325                 330                 335     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            340                 345                 350         


Leu Glu Ser Gly Gly Ser Ala Pro Val Gln Ser Ile Lys Cys Lys Leu 
        355                 360                 365             


Gln Asp Arg Glu Gln Lys Ser Leu Val Leu Ala Ser Pro Cys Val Leu 
    370                 375                 380                 


Lys Ala Leu His Leu Leu Ser Gln Glu Met Asn Arg Glu Val Val Phe 
385                 390                 395                 400 


Cys Met Ser Phe Val Gln Gly Glu Glu Arg Asp Asn Lys Ile Pro Val 
                405                 410                 415     


Ala Leu Gly Ile Lys Asp Lys Asn Leu Tyr Leu Ser Cys Val Lys Lys 
            420                 425                 430         


Gly Asp Thr Pro Thr Leu Gln Leu Glu Glu Val Asp Pro Lys Val Tyr 
        435                 440                 445             


Pro Lys Arg Asn Met Glu Lys Arg Phe Val Phe Tyr Lys Thr Glu Ile 
    450                 455                 460                 


Lys Asn Thr Val Glu Phe Glu Ser Val Leu Tyr Pro Asn Trp Tyr Ile 
465                 470                 475                 480 


Ser Thr Ser Gln Ile Glu Glu Arg Pro Val Phe Leu Gly His Phe Arg 
                485                 490                 495     


Gly Gly Gln Asp Ile Thr Asp Phe Arg Met Glu Thr Leu Ser Pro Ala 
            500                 505                 510         


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
        515                 520                 525             


Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys 
    530                 535                 540                 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His 
545                 550                 555                 560 


His 
    


<210>  232
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of canine IL1-beta polyprotein.

<400>  232

Ala Ala Met Gln Ser Val Asp Cys Lys Leu Gln Asp Ile Ser His Lys 
1               5                   10                  15      


Tyr Leu Val Leu Ser Asn Ser Tyr Glu Leu Arg Ala Leu His Leu Asn 
            20                  25                  30          


Gly Glu Asn Val Asn Lys Gln Val Val Phe His Met Ser Phe Val His 
        35                  40                  45              


Gly Asp Glu Ser Asn Asn Lys Ile Pro Val Val Leu Gly Ile Lys Gln 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Lys Val Asp Pro Lys Val Tyr Pro Lys Arg Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Lys Asn Thr Val Glu Phe 
            100                 105                 110         


Glu Ser Ser Gln Tyr Pro Asn Trp Tyr Ile Ser Thr Ser Gln Val Glu 
        115                 120                 125             


Gly Met Pro Val Phe Leu Gly Asn Thr Arg Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Thr Met Glu Phe Ser Ser Gly Ser Gly Gly Gln Tyr Ile Lys 
145                 150                 155                 160 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ala 
                165                 170                 175     


Ala Met Gln Ser Val Asp Cys Lys Leu Gln Asp Ile Ser His Lys Tyr 
            180                 185                 190         


Leu Val Leu Ser Asn Ser Tyr Glu Leu Arg Ala Leu His Leu Asn Gly 
        195                 200                 205             


Glu Asn Val Asn Lys Gln Val Val Phe His Met Ser Phe Val His Gly 
    210                 215                 220                 


Asp Glu Ser Asn Asn Lys Ile Pro Val Val Leu Gly Ile Lys Gln Lys 
225                 230                 235                 240 


Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly Lys Pro Thr Leu Gln 
                245                 250                 255     


Leu Glu Lys Val Asp Pro Lys Val Tyr Pro Lys Arg Lys Met Glu Lys 
            260                 265                 270         


Arg Phe Val Phe Asn Lys Ile Glu Ile Lys Asn Thr Val Glu Phe Glu 
        275                 280                 285             


Ser Ser Gln Tyr Pro Asn Trp Tyr Ile Ser Thr Ser Gln Val Glu Gly 
    290                 295                 300                 


Met Pro Val Phe Leu Gly Asn Thr Arg Gly Gly Gln Asp Ile Thr Asp 
305                 310                 315                 320 


Phe Thr Met Glu Phe Ser Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                325                 330                 335     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            340                 345                 350         


Ser Gly Gly Ser Ala Ala Met Gln Ser Val Asp Cys Lys Leu Gln Asp 
        355                 360                 365             


Ile Ser His Lys Tyr Leu Val Leu Ser Asn Ser Tyr Glu Leu Arg Ala 
    370                 375                 380                 


Leu His Leu Asn Gly Glu Asn Val Asn Lys Gln Val Val Phe His Met 
385                 390                 395                 400 


Ser Phe Val His Gly Asp Glu Ser Asn Asn Lys Ile Pro Val Val Leu 
                405                 410                 415     


Gly Ile Lys Gln Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly 
            420                 425                 430         


Lys Pro Thr Leu Gln Leu Glu Lys Val Asp Pro Lys Val Tyr Pro Lys 
        435                 440                 445             


Arg Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Lys Asn 
    450                 455                 460                 


Thr Val Glu Phe Glu Ser Ser Gln Tyr Pro Asn Trp Tyr Ile Ser Thr 
465                 470                 475                 480 


Ser Gln Val Glu Gly Met Pro Val Phe Leu Gly Asn Thr Arg Gly Gly 
                485                 490                 495     


Gln Asp Ile Thr Asp Phe Thr Met Glu Phe Ser Ser Ala Gly Ser Gly 
            500                 505                 510         


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
        515                 520                 525             


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    530                 535                 540                 


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
545                 550                 555             


<210>  233
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of feline IL1-beta polyprotein.

<400>  233

Ala Ala Ile Gln Ser Gln Asp Tyr Thr Phe Arg Asp Ile Ser Gln Lys 
1               5                   10                  15      


Ser Leu Val Leu Ser Gly Ser Tyr Glu Leu Arg Ala Leu His Leu Asn 
            20                  25                  30          


Gly Gln Asn Met Asn Gln Gln Val Val Phe Arg Met Ser Phe Val His 
        35                  40                  45              


Gly Glu Glu Asn Ser Lys Lys Ile Pro Val Val Leu Cys Ile Lys Lys 
    50                  55                  60                  


Asn Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Met Leu Asp Pro Lys Val Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Thr Glu Ile Lys Gly Asn Val Glu Phe 
            100                 105                 110         


Glu Ser Ser Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala Glu 
        115                 120                 125             


Glu Met Pro Val Phe Leu Gly Asn Thr Lys Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Ile Met Glu Ser Ala Ser Gly Ser Gly Gly Gln Tyr Ile Lys 
145                 150                 155                 160 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ala 
                165                 170                 175     


Ala Ile Gln Ser Gln Asp Tyr Thr Phe Arg Asp Ile Ser Gln Lys Ser 
            180                 185                 190         


Leu Val Leu Ser Gly Ser Tyr Glu Leu Arg Ala Leu His Leu Asn Gly 
        195                 200                 205             


Gln Asn Met Asn Gln Gln Val Val Phe Arg Met Ser Phe Val His Gly 
    210                 215                 220                 


Glu Glu Asn Ser Lys Lys Ile Pro Val Val Leu Cys Ile Lys Lys Asn 
225                 230                 235                 240 


Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly Lys Pro Thr Leu Gln 
                245                 250                 255     


Leu Glu Met Leu Asp Pro Lys Val Tyr Pro Lys Lys Lys Met Glu Lys 
            260                 265                 270         


Arg Phe Val Phe Asn Lys Thr Glu Ile Lys Gly Asn Val Glu Phe Glu 
        275                 280                 285             


Ser Ser Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala Glu Glu 
    290                 295                 300                 


Met Pro Val Phe Leu Gly Asn Thr Lys Gly Gly Gln Asp Ile Thr Asp 
305                 310                 315                 320 


Phe Ile Met Glu Ser Ala Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                325                 330                 335     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            340                 345                 350         


Ser Gly Gly Ser Ala Ala Ile Gln Ser Gln Asp Tyr Thr Phe Arg Asp 
        355                 360                 365             


Ile Ser Gln Lys Ser Leu Val Leu Ser Gly Ser Tyr Glu Leu Arg Ala 
    370                 375                 380                 


Leu His Leu Asn Gly Gln Asn Met Asn Gln Gln Val Val Phe Arg Met 
385                 390                 395                 400 


Ser Phe Val His Gly Glu Glu Asn Ser Lys Lys Ile Pro Val Val Leu 
                405                 410                 415     


Cys Ile Lys Lys Asn Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly 
            420                 425                 430         


Lys Pro Thr Leu Gln Leu Glu Met Leu Asp Pro Lys Val Tyr Pro Lys 
        435                 440                 445             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Thr Glu Ile Lys Gly 
    450                 455                 460                 


Asn Val Glu Phe Glu Ser Ser Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
465                 470                 475                 480 


Ser Gln Ala Glu Glu Met Pro Val Phe Leu Gly Asn Thr Lys Gly Gly 
                485                 490                 495     


Gln Asp Ile Thr Asp Phe Ile Met Glu Ser Ala Ser Ala Gly Ser Gly 
            500                 505                 510         


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
        515                 520                 525             


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    530                 535                 540                 


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
545                 550                 555             


<210>  234
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-2 polyprotein.

<400>  234

Ala Pro Ile Thr Ser Ser Ser Thr Lys Glu Thr Glu Gln Gln Met Glu 
1               5                   10                  15      


Gln Leu Leu Leu Asp Leu Gln Leu Leu Leu Asn Gly Val Asn Asn Tyr 
            20                  25                  30          


Glu Asn Pro Gln Leu Ser Arg Met Leu Thr Phe Lys Phe Tyr Thr Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Phe Thr His Leu Gln Cys Leu Ala Glu Glu Leu 
    50                  55                  60                  


Lys Asn Leu Glu Glu Val Leu Gly Leu Pro Gln Ser Lys Asn Val His 
65                  70                  75                  80  


Leu Thr Asp Thr Lys Glu Leu Ile Ser Asn Met Asn Val Thr Leu Leu 
                85                  90                  95      


Lys Leu Lys Gly Ser Glu Thr Ser Tyr Asn Cys Glu Tyr Asp Asp Glu 
            100                 105                 110         


Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys Trp Ile Thr Phe Cys Gln 
        115                 120                 125             


Ser Ile Phe Ser Thr Leu Thr Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
    130                 135                 140                 


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ala Pro 
145                 150                 155                 160 


Ile Thr Ser Ser Ser Thr Lys Glu Thr Glu Gln Gln Met Glu Gln Leu 
                165                 170                 175     


Leu Leu Asp Leu Gln Leu Leu Leu Asn Gly Val Asn Asn Tyr Glu Asn 
            180                 185                 190         


Pro Gln Leu Ser Arg Met Leu Thr Phe Lys Phe Tyr Thr Pro Lys Lys 
        195                 200                 205             


Ala Thr Glu Phe Thr His Leu Gln Cys Leu Ala Glu Glu Leu Lys Asn 
    210                 215                 220                 


Leu Glu Glu Val Leu Gly Leu Pro Gln Ser Lys Asn Val His Leu Thr 
225                 230                 235                 240 


Asp Thr Lys Glu Leu Ile Ser Asn Met Asn Val Thr Leu Leu Lys Leu 
                245                 250                 255     


Lys Gly Ser Glu Thr Ser Tyr Asn Cys Glu Tyr Asp Asp Glu Thr Ala 
            260                 265                 270         


Thr Ile Thr Glu Phe Leu Asn Lys Trp Ile Thr Phe Cys Gln Ser Ile 
        275                 280                 285             


Phe Ser Thr Leu Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
    290                 295                 300                 


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
305                 310                 315                 320 


Gly Ser Ala Pro Ile Thr Ser Ser Ser Thr Lys Glu Thr Glu Gln Gln 
                325                 330                 335     


Met Glu Gln Leu Leu Leu Asp Leu Gln Leu Leu Leu Asn Gly Val Asn 
            340                 345                 350         


Asn Tyr Glu Asn Pro Gln Leu Ser Arg Met Leu Thr Phe Lys Phe Tyr 
        355                 360                 365             


Thr Pro Lys Lys Ala Thr Glu Phe Thr His Leu Gln Cys Leu Ala Glu 
    370                 375                 380                 


Glu Leu Lys Asn Leu Glu Glu Val Leu Gly Leu Pro Gln Ser Lys Asn 
385                 390                 395                 400 


Val His Leu Thr Asp Thr Lys Glu Leu Ile Ser Asn Met Asn Val Thr 
                405                 410                 415     


Leu Leu Lys Leu Lys Gly Ser Glu Thr Ser Tyr Asn Cys Glu Tyr Asp 
            420                 425                 430         


Asp Glu Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys Trp Ile Thr Phe 
        435                 440                 445             


Cys Gln Ser Ile Phe Ser Thr Leu Thr Ala Gly Ser Gly Phe Asn Asn 
    450                 455                 460                 


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
465                 470                 475                 480 


Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
                485                 490                 495     


Gly Ile Thr Glu Leu His His His His His His 
            500                 505         


<210>  235
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-2 polyprotein.

<400>  235

Ala Pro Ala Ser Ser Ser Thr Lys Glu Thr Gln Gln Gln Leu Glu Gln 
1               5                   10                  15      


Leu Leu Leu Asp Leu Arg Leu Leu Leu Asn Gly Val Asn Asn Pro Glu 
            20                  25                  30          


Asn Pro Lys Leu Ser Arg Met Leu Thr Phe Lys Phe Tyr Val Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Thr His Leu Gln Cys Leu Val Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Tyr Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Asn His Ile Lys Glu Leu Met Ser Asn Ile Asn Val Thr Val Leu Lys 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Arg Phe Thr Cys Asn Tyr Asp Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Lys Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Phe Ser Thr Leu Thr Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
    130                 135                 140                 


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ala Pro Ala 
145                 150                 155                 160 


Ser Ser Ser Thr Lys Glu Thr Gln Gln Gln Leu Glu Gln Leu Leu Leu 
                165                 170                 175     


Asp Leu Arg Leu Leu Leu Asn Gly Val Asn Asn Pro Glu Asn Pro Lys 
            180                 185                 190         


Leu Ser Arg Met Leu Thr Phe Lys Phe Tyr Val Pro Lys Lys Ala Thr 
        195                 200                 205             


Glu Leu Thr His Leu Gln Cys Leu Val Glu Glu Leu Lys Pro Leu Glu 
    210                 215                 220                 


Glu Val Leu Tyr Leu Ala Gln Ser Lys Asn Phe His Leu Asn His Ile 
225                 230                 235                 240 


Lys Glu Leu Met Ser Asn Ile Asn Val Thr Val Leu Lys Leu Lys Gly 
                245                 250                 255     


Ser Glu Thr Arg Phe Thr Cys Asn Tyr Asp Asp Glu Thr Ala Thr Ile 
            260                 265                 270         


Val Glu Phe Leu Asn Lys Trp Ile Thr Phe Cys Gln Ser Ile Phe Ser 
        275                 280                 285             


Thr Leu Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
    290                 295                 300                 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
305                 310                 315                 320 


Ala Pro Ala Ser Ser Ser Thr Lys Glu Thr Gln Gln Gln Leu Glu Gln 
                325                 330                 335     


Leu Leu Leu Asp Leu Arg Leu Leu Leu Asn Gly Val Asn Asn Pro Glu 
            340                 345                 350         


Asn Pro Lys Leu Ser Arg Met Leu Thr Phe Lys Phe Tyr Val Pro Lys 
        355                 360                 365             


Lys Ala Thr Glu Leu Thr His Leu Gln Cys Leu Val Glu Glu Leu Lys 
    370                 375                 380                 


Pro Leu Glu Glu Val Leu Tyr Leu Ala Gln Ser Lys Asn Phe His Leu 
385                 390                 395                 400 


Asn His Ile Lys Glu Leu Met Ser Asn Ile Asn Val Thr Val Leu Lys 
                405                 410                 415     


Leu Lys Gly Ser Glu Thr Arg Phe Thr Cys Asn Tyr Asp Asp Glu Thr 
            420                 425                 430         


Ala Thr Ile Val Glu Phe Leu Asn Lys Trp Ile Thr Phe Cys Gln Ser 
        435                 440                 445             


Ile Phe Ser Thr Leu Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
    450                 455                 460                 


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
465                 470                 475                 480 


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
                485                 490                 495     


Glu Leu His His His His His His 
            500                 


<210>  236
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-2 polyprotein.

<400>  236

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    130                 135                 140                 


Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ala Pro Thr Ser 
145                 150                 155                 160 


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
                165                 170                 175     


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
            180                 185                 190         


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
        195                 200                 205             


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
    210                 215                 220                 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
225                 230                 235                 240 


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
                245                 250                 255     


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
            260                 265                 270         


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
        275                 280                 285             


Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
    290                 295                 300                 


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Ala Pro 
305                 310                 315                 320 


Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu 
                325                 330                 335     


Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro 
            340                 345                 350         


Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala 
        355                 360                 365             


Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu 
    370                 375                 380                 


Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro 
385                 390                 395                 400 


Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly 
                405                 410                 415     


Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile 
            420                 425                 430         


Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser 
        435                 440                 445             


Thr Leu Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
    450                 455                 460                 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly 
465                 470                 475                 480 


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His 
                485                 490                 495     


His His His His His 
            500     


<210>  237
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-3 polyprotein.

<400>  237

Arg Pro Phe Ser Thr Asp Leu Pro Lys Gln Tyr Phe Thr Met Ile Asn 
1               5                   10                  15      


Glu Ile Met Glu Met Leu Asn Lys Ser Pro Ser Pro Ser Glu Glu Pro 
            20                  25                  30          


Leu Asp Ser Asn Glu Lys Glu Thr Leu Leu Glu Asp Thr Leu Leu Arg 
        35                  40                  45              


Pro Asn Leu Asp Val Phe Leu Asn Ala Ser Ser Lys Phe His Lys Asn 
    50                  55                  60                  


Gly Leu Leu Ile Trp Asn Asn Leu Lys Glu Phe Leu Pro Leu Leu Pro 
65                  70                  75                  80  


Thr Pro Thr Pro Arg Gly Glu Pro Ile Ser Ile Met Glu Asn Asn Trp 
                85                  90                  95      


Gly Asp Phe Gln Arg Lys Leu Lys Lys Tyr Leu Glu Ala Leu Asp Asn 
            100                 105                 110         


Phe Leu Asn Phe Lys Asn Lys Pro Gly Ser Gly Gly Gln Tyr Ile Lys 
        115                 120                 125             


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Arg 
    130                 135                 140                 


Pro Phe Ser Thr Asp Leu Pro Lys Gln Tyr Phe Thr Met Ile Asn Glu 
145                 150                 155                 160 


Ile Met Glu Met Leu Asn Lys Ser Pro Ser Pro Ser Glu Glu Pro Leu 
                165                 170                 175     


Asp Ser Asn Glu Lys Glu Thr Leu Leu Glu Asp Thr Leu Leu Arg Pro 
            180                 185                 190         


Asn Leu Asp Val Phe Leu Asn Ala Ser Ser Lys Phe His Lys Asn Gly 
        195                 200                 205             


Leu Leu Ile Trp Asn Asn Leu Lys Glu Phe Leu Pro Leu Leu Pro Thr 
    210                 215                 220                 


Pro Thr Pro Arg Gly Glu Pro Ile Ser Ile Met Glu Asn Asn Trp Gly 
225                 230                 235                 240 


Asp Phe Gln Arg Lys Leu Lys Lys Tyr Leu Glu Ala Leu Asp Asn Phe 
                245                 250                 255     


Leu Asn Phe Lys Asn Lys Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr 
            260                 265                 270         


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
        275                 280                 285             


Ser Gly Gly Ser Arg Pro Phe Ser Thr Asp Leu Pro Lys Gln Tyr Phe 
    290                 295                 300                 


Thr Met Ile Asn Glu Ile Met Glu Met Leu Asn Lys Ser Pro Ser Pro 
305                 310                 315                 320 


Ser Glu Glu Pro Leu Asp Ser Asn Glu Lys Glu Thr Leu Leu Glu Asp 
                325                 330                 335     


Thr Leu Leu Arg Pro Asn Leu Asp Val Phe Leu Asn Ala Ser Ser Lys 
            340                 345                 350         


Phe His Lys Asn Gly Leu Leu Ile Trp Asn Asn Leu Lys Glu Phe Leu 
        355                 360                 365             


Pro Leu Leu Pro Thr Pro Thr Pro Arg Gly Glu Pro Ile Ser Ile Met 
    370                 375                 380                 


Glu Asn Asn Trp Gly Asp Phe Gln Arg Lys Leu Lys Lys Tyr Leu Glu 
385                 390                 395                 400 


Ala Leu Asp Asn Phe Leu Asn Phe Lys Asn Lys Pro Ala Gly Ser Gly 
                405                 410                 415     


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
            420                 425                 430         


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
        435                 440                 445             


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
    450                 455                 460         


<210>  238
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-3 polyprotein.

<400>  238

Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp Val Asn Cys 
1               5                   10                  15      


Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu 
            20                  25                  30          


Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu 
        35                  40                  45              


Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala 
    50                  55                  60                  


Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn 
65                  70                  75                  80  


Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro 
                85                  90                  95      


Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr 
            100                 105                 110         


Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu 
        115                 120                 125             


Ser Leu Ala Ile Phe Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    130                 135                 140                 


Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ala Pro Met Thr 
145                 150                 155                 160 


Gln Thr Thr Pro Leu Lys Thr Ser Trp Val Asn Cys Ser Asn Met Ile 
                165                 170                 175     


Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp 
            180                 185                 190         


Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn 
        195                 200                 205             


Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu 
    210                 215                 220                 


Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys 
225                 230                 235                 240 


Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His Ile Lys 
                245                 250                 255     


Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys 
            260                 265                 270         


Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu Ser Leu Ala Ile 
        275                 280                 285             


Phe Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
    290                 295                 300                 


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Ala Pro 
305                 310                 315                 320 


Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp Val Asn Cys Ser Asn 
                325                 330                 335     


Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu Pro Leu 
            340                 345                 350         


Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu Met Glu 
        355                 360                 365             


Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala Val Lys 
    370                 375                 380                 


Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn Leu Leu 
385                 390                 395                 400 


Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro Ile His 
                405                 410                 415     


Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr Phe Tyr 
            420                 425                 430         


Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu Ser Leu 
        435                 440                 445             


Ala Ile Phe Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
    450                 455                 460                 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly 
465                 470                 475                 480 


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His 
                485                 490                 495     


His His His His His 
            500     


<210>  239
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-6 polyprotein.

<400>  239

Phe Pro Thr Pro Gly Pro Leu Ala Gly Asp Ser Lys Asp Asp Ala Thr 
1               5                   10                  15      


Ser Asn Ser Leu Pro Leu Thr Ser Ala Asn Lys Val Glu Glu Leu Ile 
            20                  25                  30          


Lys Tyr Ile Leu Gly Lys Ile Ser Ala Leu Arg Lys Glu Met Cys Asp 
        35                  40                  45              


Lys Phe Asn Lys Cys Glu Asp Ser Lys Glu Ala Leu Ala Glu Asn Asn 
    50                  55                  60                  


Leu His Leu Pro Lys Leu Glu Gly Lys Asp Gly Cys Phe Gln Ser Gly 
65                  70                  75                  80  


Phe Asn Gln Glu Thr Cys Leu Thr Arg Ile Thr Thr Gly Leu Val Glu 
                85                  90                  95      


Phe Gln Leu His Leu Asn Ile Leu Gln Asn Asn Tyr Glu Gly Asp Lys 
            100                 105                 110         


Glu Asn Val Lys Ser Val His Met Ser Thr Lys Ile Leu Val Gln Met 
        115                 120                 125             


Leu Lys Ser Lys Val Lys Asn Gln Asp Glu Val Thr Thr Pro Asp Pro 
    130                 135                 140                 


Thr Thr Asp Ala Ser Leu Gln Ala Ile Leu Gln Ser Gln Asp Glu Cys 
145                 150                 155                 160 


Val Lys His Thr Thr Ile His Leu Ile Leu Arg Ser Leu Glu Asp Phe 
                165                 170                 175     


Leu Gln Phe Ser Leu Arg Ala Val Arg Ile Met Gly Ser Gly Gly Gln 
            180                 185                 190         


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly 
        195                 200                 205             


Ser Gly Phe Pro Thr Pro Gly Pro Leu Ala Gly Asp Ser Lys Asp Asp 
    210                 215                 220                 


Ala Thr Ser Asn Ser Leu Pro Leu Thr Ser Ala Asn Lys Val Glu Glu 
225                 230                 235                 240 


Leu Ile Lys Tyr Ile Leu Gly Lys Ile Ser Ala Leu Arg Lys Glu Met 
                245                 250                 255     


Cys Asp Lys Phe Asn Lys Cys Glu Asp Ser Lys Glu Ala Leu Ala Glu 
            260                 265                 270         


Asn Asn Leu His Leu Pro Lys Leu Glu Gly Lys Asp Gly Cys Phe Gln 
        275                 280                 285             


Ser Gly Phe Asn Gln Glu Thr Cys Leu Thr Arg Ile Thr Thr Gly Leu 
    290                 295                 300                 


Val Glu Phe Gln Leu His Leu Asn Ile Leu Gln Asn Asn Tyr Glu Gly 
305                 310                 315                 320 


Asp Lys Glu Asn Val Lys Ser Val His Met Ser Thr Lys Ile Leu Val 
                325                 330                 335     


Gln Met Leu Lys Ser Lys Val Lys Asn Gln Asp Glu Val Thr Thr Pro 
            340                 345                 350         


Asp Pro Thr Thr Asp Ala Ser Leu Gln Ala Ile Leu Gln Ser Gln Asp 
        355                 360                 365             


Glu Cys Val Lys His Thr Thr Ile His Leu Ile Leu Arg Ser Leu Glu 
    370                 375                 380                 


Asp Phe Leu Gln Phe Ser Leu Arg Ala Val Arg Ile Met Ala Gly Ser 
385                 390                 395                 400 


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
                405                 410                 415     


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Phe Pro Thr Pro Gly Pro 
            420                 425                 430         


Leu Ala Gly Asp Ser Lys Asp Asp Ala Thr Ser Asn Ser Leu Pro Leu 
        435                 440                 445             


Thr Ser Ala Asn Lys Val Glu Glu Leu Ile Lys Tyr Ile Leu Gly Lys 
    450                 455                 460                 


Ile Ser Ala Leu Arg Lys Glu Met Cys Asp Lys Phe Asn Lys Cys Glu 
465                 470                 475                 480 


Asp Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu His Leu Pro Lys Leu 
                485                 490                 495     


Glu Gly Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Gln Glu Thr Cys 
            500                 505                 510         


Leu Thr Arg Ile Thr Thr Gly Leu Val Glu Phe Gln Leu His Leu Asn 
        515                 520                 525             


Ile Leu Gln Asn Asn Tyr Glu Gly Asp Lys Glu Asn Val Lys Ser Val 
    530                 535                 540                 


His Met Ser Thr Lys Ile Leu Val Gln Met Leu Lys Ser Lys Val Lys 
545                 550                 555                 560 


Asn Gln Asp Glu Val Thr Thr Pro Asp Pro Thr Thr Asp Ala Ser Leu 
                565                 570                 575     


Gln Ala Ile Leu Gln Ser Gln Asp Glu Cys Val Lys His Thr Thr Ile 
            580                 585                 590         


His Leu Ile Leu Arg Ser Leu Glu Asp Phe Leu Gln Phe Ser Leu Arg 
        595                 600                 605             


Ala Val Arg Ile Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
    610                 615                 620                 


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser 
625                 630                 635                 640 


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
                645                 650                 655     


Leu His His His His His His 
            660             


<210>  240
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-6 polyprotein.

<400>  240

Thr Pro Gly Pro Leu Gly Gly Asp Ala Thr Ser Asn Arg Leu Pro Leu 
1               5                   10                  15      


Thr Ser Ala Asp Lys Met Glu Glu Leu Ile Lys Tyr Ile Leu Gly Lys 
            20                  25                  30          


Ile Ser Ala Leu Lys Lys Glu Met Cys Asp Asn Tyr Asn Lys Cys Glu 
        35                  40                  45              


Asp Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Leu 
    50                  55                  60                  


Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Gln Glu Thr Cys 
65                  70                  75                  80  


Leu Thr Arg Ile Thr Thr Gly Leu Gln Glu Phe Gln Ile Tyr Leu Lys 
                85                  90                  95      


Phe Leu Gln Asp Lys Tyr Glu Gly Asp Glu Glu Asn Ala Lys Ser Val 
            100                 105                 110         


Tyr Thr Ser Thr Asn Val Leu Leu Gln Met Leu Lys Arg Lys Gly Lys 
        115                 120                 125             


Asn Gln Asp Glu Val Thr Ile Pro Val Pro Thr Val Glu Val Gly Leu 
    130                 135                 140                 


Gln Ala Lys Leu Gln Ser Gln Glu Glu Trp Leu Arg His Thr Thr Ile 
145                 150                 155                 160 


His Leu Thr Leu Arg Arg Leu Glu Asp Phe Leu Gln Phe Ser Leu Arg 
                165                 170                 175     


Ala Val Arg Ile Met Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
            180                 185                 190         


Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Thr Pro Gly Pro 
        195                 200                 205             


Leu Gly Gly Asp Ala Thr Ser Asn Arg Leu Pro Leu Thr Ser Ala Asp 
    210                 215                 220                 


Lys Met Glu Glu Leu Ile Lys Tyr Ile Leu Gly Lys Ile Ser Ala Leu 
225                 230                 235                 240 


Lys Lys Glu Met Cys Asp Asn Tyr Asn Lys Cys Glu Asp Ser Lys Glu 
                245                 250                 255     


Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Leu Ala Glu Lys Asp 
            260                 265                 270         


Gly Cys Phe Gln Ser Gly Phe Asn Gln Glu Thr Cys Leu Thr Arg Ile 
        275                 280                 285             


Thr Thr Gly Leu Gln Glu Phe Gln Ile Tyr Leu Lys Phe Leu Gln Asp 
    290                 295                 300                 


Lys Tyr Glu Gly Asp Glu Glu Asn Ala Lys Ser Val Tyr Thr Ser Thr 
305                 310                 315                 320 


Asn Val Leu Leu Gln Met Leu Lys Arg Lys Gly Lys Asn Gln Asp Glu 
                325                 330                 335     


Val Thr Ile Pro Val Pro Thr Val Glu Val Gly Leu Gln Ala Lys Leu 
            340                 345                 350         


Gln Ser Gln Glu Glu Trp Leu Arg His Thr Thr Ile His Leu Thr Leu 
        355                 360                 365             


Arg Arg Leu Glu Asp Phe Leu Gln Phe Ser Leu Arg Ala Val Arg Ile 
    370                 375                 380                 


Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
385                 390                 395                 400 


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Thr Pro 
                405                 410                 415     


Gly Pro Leu Gly Gly Asp Ala Thr Ser Asn Arg Leu Pro Leu Thr Ser 
            420                 425                 430         


Ala Asp Lys Met Glu Glu Leu Ile Lys Tyr Ile Leu Gly Lys Ile Ser 
        435                 440                 445             


Ala Leu Lys Lys Glu Met Cys Asp Asn Tyr Asn Lys Cys Glu Asp Ser 
    450                 455                 460                 


Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Leu Ala Glu 
465                 470                 475                 480 


Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Gln Glu Thr Cys Leu Thr 
                485                 490                 495     


Arg Ile Thr Thr Gly Leu Gln Glu Phe Gln Ile Tyr Leu Lys Phe Leu 
            500                 505                 510         


Gln Asp Lys Tyr Glu Gly Asp Glu Glu Asn Ala Lys Ser Val Tyr Thr 
        515                 520                 525             


Ser Thr Asn Val Leu Leu Gln Met Leu Lys Arg Lys Gly Lys Asn Gln 
    530                 535                 540                 


Asp Glu Val Thr Ile Pro Val Pro Thr Val Glu Val Gly Leu Gln Ala 
545                 550                 555                 560 


Lys Leu Gln Ser Gln Glu Glu Trp Leu Arg His Thr Thr Ile His Leu 
                565                 570                 575     


Thr Leu Arg Arg Leu Glu Asp Phe Leu Gln Phe Ser Leu Arg Ala Val 
            580                 585                 590         


Arg Ile Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
        595                 600                 605             


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly 
    610                 615                 620                 


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His 
625                 630                 635                 640 


His His His His His 
                645 


<210>  241
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-6 polyprotein.

<400>  241

Val Pro Pro Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln 
1               5                   10                  15      


Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu 
            20                  25                  30          


Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met 
        35                  40                  45              


Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro 
    50                  55                  60                  


Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu 
65                  70                  75                  80  


Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr 
                85                  90                  95      


Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg 
            100                 105                 110         


Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys 
        115                 120                 125             


Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala 
    130                 135                 140                 


Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met 
145                 150                 155                 160 


Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser 
                165                 170                 175     


Leu Arg Ala Leu Arg Gln Met Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
            180                 185                 190         


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Val Pro 
        195                 200                 205             


Pro Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu 
    210                 215                 220                 


Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly 
225                 230                 235                 240 


Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu 
                245                 250                 255     


Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met 
            260                 265                 270         


Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys 
        275                 280                 285             


Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu 
    290                 295                 300                 


Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val 
305                 310                 315                 320 


Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys 
                325                 330                 335     


Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu 
            340                 345                 350         


Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr 
        355                 360                 365             


His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg 
    370                 375                 380                 


Ala Leu Arg Gln Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
385                 390                 395                 400 


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
                405                 410                 415     


Gly Ser Val Pro Pro Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His 
            420                 425                 430         


Arg Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr 
        435                 440                 445             


Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser 
    450                 455                 460                 


Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn 
465                 470                 475                 480 


Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn 
                485                 490                 495     


Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu 
            500                 505                 510         


Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln 
        515                 520                 525             


Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln 
    530                 535                 540                 


Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr 
545                 550                 555                 560 


Asn Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln 
                565                 570                 575     


Asp Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln 
            580                 585                 590         


Ser Ser Leu Arg Ala Leu Arg Gln Met Ala Gly Ser Gly Phe Asn Asn 
        595                 600                 605             


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
    610                 615                 620                 


Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
625                 630                 635                 640 


Gly Ile Thr Glu Leu His His His His His His 
                645                 650     


<210>  242
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine IL-6 polyprotein.

<400>  242

Gly Pro Leu Gly Glu Asp Phe Lys Asn Asp Thr Thr Pro Gly Arg Leu 
1               5                   10                  15      


Leu Leu Thr Thr Pro Glu Lys Thr Glu Ala Leu Ile Lys Arg Met Val 
            20                  25                  30          


Asp Lys Ile Ser Ala Met Arg Lys Glu Ile Cys Glu Lys Asn Asp Glu 
        35                  40                  45              


Cys Glu Ser Ser Lys Glu Thr Leu Ala Glu Asn Lys Leu Asn Leu Pro 
    50                  55                  60                  


Lys Met Glu Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Gln Ala 
65                  70                  75                  80  


Ile Cys Leu Ile Arg Thr Thr Ala Gly Leu Leu Glu Tyr Gln Ile Tyr 
                85                  90                  95      


Leu Asp Tyr Leu Gln Asn Glu Tyr Glu Gly Asn Gln Glu Asn Val Arg 
            100                 105                 110         


Asp Leu Arg Lys Asn Ile Arg Thr Leu Ile Gln Ile Leu Lys Gln Lys 
        115                 120                 125             


Ile Ala Asp Leu Ile Thr Thr Pro Ala Thr Asn Thr Asp Leu Leu Glu 
    130                 135                 140                 


Lys Met Gln Ser Ser Asn Glu Trp Val Lys Asn Ala Lys Ile Ile Leu 
145                 150                 155                 160 


Ile Leu Arg Asn Leu Glu Asn Phe Leu Gln Phe Ser Leu Arg Ala Ile 
                165                 170                 175     


Arg Met Lys Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
            180                 185                 190         


Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Gly Pro Leu Gly Glu Asp 
        195                 200                 205             


Phe Lys Asn Asp Thr Thr Pro Gly Arg Leu Leu Leu Thr Thr Pro Glu 
    210                 215                 220                 


Lys Thr Glu Ala Leu Ile Lys Arg Met Val Asp Lys Ile Ser Ala Met 
225                 230                 235                 240 


Arg Lys Glu Ile Cys Glu Lys Asn Asp Glu Cys Glu Ser Ser Lys Glu 
                245                 250                 255     


Thr Leu Ala Glu Asn Lys Leu Asn Leu Pro Lys Met Glu Glu Lys Asp 
            260                 265                 270         


Gly Cys Phe Gln Ser Gly Phe Asn Gln Ala Ile Cys Leu Ile Arg Thr 
        275                 280                 285             


Thr Ala Gly Leu Leu Glu Tyr Gln Ile Tyr Leu Asp Tyr Leu Gln Asn 
    290                 295                 300                 


Glu Tyr Glu Gly Asn Gln Glu Asn Val Arg Asp Leu Arg Lys Asn Ile 
305                 310                 315                 320 


Arg Thr Leu Ile Gln Ile Leu Lys Gln Lys Ile Ala Asp Leu Ile Thr 
                325                 330                 335     


Thr Pro Ala Thr Asn Thr Asp Leu Leu Glu Lys Met Gln Ser Ser Asn 
            340                 345                 350         


Glu Trp Val Lys Asn Ala Lys Ile Ile Leu Ile Leu Arg Asn Leu Glu 
        355                 360                 365             


Asn Phe Leu Gln Phe Ser Leu Arg Ala Ile Arg Met Lys Ala Gly Ser 
    370                 375                 380                 


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
385                 390                 395                 400 


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Gly Pro Leu Gly Glu Asp 
                405                 410                 415     


Phe Lys Asn Asp Thr Thr Pro Gly Arg Leu Leu Leu Thr Thr Pro Glu 
            420                 425                 430         


Lys Thr Glu Ala Leu Ile Lys Arg Met Val Asp Lys Ile Ser Ala Met 
        435                 440                 445             


Arg Lys Glu Ile Cys Glu Lys Asn Asp Glu Cys Glu Ser Ser Lys Glu 
    450                 455                 460                 


Thr Leu Ala Glu Asn Lys Leu Asn Leu Pro Lys Met Glu Glu Lys Asp 
465                 470                 475                 480 


Gly Cys Phe Gln Ser Gly Phe Asn Gln Ala Ile Cys Leu Ile Arg Thr 
                485                 490                 495     


Thr Ala Gly Leu Leu Glu Tyr Gln Ile Tyr Leu Asp Tyr Leu Gln Asn 
            500                 505                 510         


Glu Tyr Glu Gly Asn Gln Glu Asn Val Arg Asp Leu Arg Lys Asn Ile 
        515                 520                 525             


Arg Thr Leu Ile Gln Ile Leu Lys Gln Lys Ile Ala Asp Leu Ile Thr 
    530                 535                 540                 


Thr Pro Ala Thr Asn Thr Asp Leu Leu Glu Lys Met Gln Ser Ser Asn 
545                 550                 555                 560 


Glu Trp Val Lys Asn Ala Lys Ile Ile Leu Ile Leu Arg Asn Leu Glu 
                565                 570                 575     


Asn Phe Leu Gln Phe Ser Leu Arg Ala Ile Arg Met Lys Ala Gly Ser 
            580                 585                 590         


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
        595                 600                 605             


Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
    610                 615                 620                 


Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
625                 630                 635                 


<210>  243
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-7 polyprotein.

<400>  243

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Gly Ser Gly Gly Gln Tyr Ile Lys 
145                 150                 155                 160 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Asp 
                165                 170                 175     


Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met 
            180                 185                 190         


Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn 
        195                 200                 205             


Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala 
    210                 215                 220                 


Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln 
225                 230                 235                 240 


Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys 
                245                 250                 255     


Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys 
            260                 265                 270         


Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu 
        275                 280                 285             


Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys 
    290                 295                 300                 


Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile 
305                 310                 315                 320 


Leu Met Gly Thr Lys Glu His Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                325                 330                 335     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            340                 345                 350         


Ser Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr 
        355                 360                 365             


Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys 
    370                 375                 380                 


Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg 
385                 390                 395                 400 


His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala 
                405                 410                 415     


Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp 
            420                 425                 430         


Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys 
        435                 440                 445             


Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln 
    450                 455                 460                 


Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys 
465                 470                 475                 480 


Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr 
                485                 490                 495     


Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Ala Gly Ser Gly 
            500                 505                 510         


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
        515                 520                 525             


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    530                 535                 540                 


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
545                 550                 555             


<210>  244
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-8 polyprotein.

<400>  244

Ala Val Leu Ser Arg Val Ser Ser Glu Leu Arg Cys Gln Cys Ile Lys 
1               5                   10                  15      


Thr His Ser Thr Pro Phe His Pro Lys Tyr Ile Lys Glu Leu Arg Val 
            20                  25                  30          


Ile Asp Ser Gly Pro His Cys Glu Asn Ser Glu Ile Ile Val Lys Leu 
        35                  40                  45              


Phe Asn Gly Asn Glu Val Cys Leu Asp Pro Lys Glu Lys Trp Val Gln 
    50                  55                  60                  


Lys Val Val Gln Ile Phe Leu Lys Lys Ala Glu Lys Gln Asp Pro Gly 
65                  70                  75                  80  


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
                85                  90                  95      


Glu Leu Ala Gly Ser Gly Ala Val Leu Ser Arg Val Ser Ser Glu Leu 
            100                 105                 110         


Arg Cys Gln Cys Ile Lys Thr His Ser Thr Pro Phe His Pro Lys Tyr 
        115                 120                 125             


Ile Lys Glu Leu Arg Val Ile Asp Ser Gly Pro His Cys Glu Asn Ser 
    130                 135                 140                 


Glu Ile Ile Val Lys Leu Phe Asn Gly Asn Glu Val Cys Leu Asp Pro 
145                 150                 155                 160 


Lys Glu Lys Trp Val Gln Lys Val Val Gln Ile Phe Leu Lys Lys Ala 
                165                 170                 175     


Glu Lys Gln Asp Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
            180                 185                 190         


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
        195                 200                 205             


Gly Ser Ala Val Leu Ser Arg Val Ser Ser Glu Leu Arg Cys Gln Cys 
    210                 215                 220                 


Ile Lys Thr His Ser Thr Pro Phe His Pro Lys Tyr Ile Lys Glu Leu 
225                 230                 235                 240 


Arg Val Ile Asp Ser Gly Pro His Cys Glu Asn Ser Glu Ile Ile Val 
                245                 250                 255     


Lys Leu Phe Asn Gly Asn Glu Val Cys Leu Asp Pro Lys Glu Lys Trp 
            260                 265                 270         


Val Gln Lys Val Val Gln Ile Phe Leu Lys Lys Ala Glu Lys Gln Asp 
        275                 280                 285             


Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
    290                 295                 300                 


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
305                 310                 315                 320 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
                325                 330                 335     


His His His 
            


<210>  245
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-8 polyprotein.

<400>  245

Ala Val Leu Ser Arg Ile Ser Ser Glu Leu Arg Cys Gln Cys Ile Lys 
1               5                   10                  15      


Thr His Ser Thr Pro Phe Asn Pro Lys Leu Ile Lys Glu Leu Thr Val 
            20                  25                  30          


Ile Asp Ser Gly Pro His Cys Glu Asn Ser Glu Ile Ile Val Lys Leu 
        35                  40                  45              


Val Asn Gly Lys Glu Val Cys Leu Asp Pro Lys Gln Lys Trp Val Gln 
    50                  55                  60                  


Lys Val Val Glu Ile Phe Leu Lys Lys Ala Glu Lys Gln Asn Ala Gly 
65                  70                  75                  80  


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
                85                  90                  95      


Glu Leu Ala Gly Ser Gly Ala Val Leu Ser Arg Ile Ser Ser Glu Leu 
            100                 105                 110         


Arg Cys Gln Cys Ile Lys Thr His Ser Thr Pro Phe Asn Pro Lys Leu 
        115                 120                 125             


Ile Lys Glu Leu Thr Val Ile Asp Ser Gly Pro His Cys Glu Asn Ser 
    130                 135                 140                 


Glu Ile Ile Val Lys Leu Val Asn Gly Lys Glu Val Cys Leu Asp Pro 
145                 150                 155                 160 


Lys Gln Lys Trp Val Gln Lys Val Val Glu Ile Phe Leu Lys Lys Ala 
                165                 170                 175     


Glu Lys Gln Asn Ala Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
            180                 185                 190         


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
        195                 200                 205             


Gly Ser Ala Val Leu Ser Arg Ile Ser Ser Glu Leu Arg Cys Gln Cys 
    210                 215                 220                 


Ile Lys Thr His Ser Thr Pro Phe Asn Pro Lys Leu Ile Lys Glu Leu 
225                 230                 235                 240 


Thr Val Ile Asp Ser Gly Pro His Cys Glu Asn Ser Glu Ile Ile Val 
                245                 250                 255     


Lys Leu Val Asn Gly Lys Glu Val Cys Leu Asp Pro Lys Gln Lys Trp 
            260                 265                 270         


Val Gln Lys Val Val Glu Ile Phe Leu Lys Lys Ala Glu Lys Gln Asn 
        275                 280                 285             


Ala Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
    290                 295                 300                 


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
305                 310                 315                 320 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
                325                 330                 335     


His His His 
            


<210>  246
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine IL-8 polyprotein.

<400>  246

Ala Val Leu Ser Arg Met Ser Thr Glu Leu Arg Cys Gln Cys Ile Lys 
1               5                   10                  15      


Thr His Ser Thr Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val 
            20                  25                  30          


Ile Glu Ser Gly Pro His Cys Glu Asn Ser Glu Ile Ile Val Lys Leu 
        35                  40                  45              


Thr Asn Gly Asn Glu Val Cys Leu Asn Pro Lys Glu Lys Trp Val Gln 
    50                  55                  60                  


Lys Val Val Gln Val Phe Val Lys Arg Ala Glu Lys Gln Asp Pro Gly 
65                  70                  75                  80  


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
                85                  90                  95      


Glu Leu Ala Gly Ser Gly Ala Val Leu Ser Arg Met Ser Thr Glu Leu 
            100                 105                 110         


Arg Cys Gln Cys Ile Lys Thr His Ser Thr Pro Phe His Pro Lys Phe 
        115                 120                 125             


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Glu Asn Ser 
    130                 135                 140                 


Glu Ile Ile Val Lys Leu Thr Asn Gly Asn Glu Val Cys Leu Asn Pro 
145                 150                 155                 160 


Lys Glu Lys Trp Val Gln Lys Val Val Gln Val Phe Val Lys Arg Ala 
                165                 170                 175     


Glu Lys Gln Asp Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
            180                 185                 190         


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
        195                 200                 205             


Gly Ser Ala Val Leu Ser Arg Met Ser Thr Glu Leu Arg Cys Gln Cys 
    210                 215                 220                 


Ile Lys Thr His Ser Thr Pro Phe His Pro Lys Phe Ile Lys Glu Leu 
225                 230                 235                 240 


Arg Val Ile Glu Ser Gly Pro His Cys Glu Asn Ser Glu Ile Ile Val 
                245                 250                 255     


Lys Leu Thr Asn Gly Asn Glu Val Cys Leu Asn Pro Lys Glu Lys Trp 
            260                 265                 270         


Val Gln Lys Val Val Gln Val Phe Val Lys Arg Ala Glu Lys Gln Asp 
        275                 280                 285             


Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
    290                 295                 300                 


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
305                 310                 315                 320 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
                325                 330                 335     


His His His 
            


<210>  247
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-8 (21-99) 
       polyprotein.

<400>  247

Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys 
1               5                   10                  15      


Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu 
            20                  25                  30          


Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val 
        35                  40                  45              


Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp 
    50                  55                  60                  


Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser Gly 
65                  70                  75                  80  


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
                85                  90                  95      


Glu Leu Ala Gly Ser Gly Glu Gly Ala Val Leu Pro Arg Ser Ala Lys 
            100                 105                 110         


Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro 
        115                 120                 125             


Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala 
    130                 135                 140                 


Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu 
145                 150                 155                 160 


Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys 
                165                 170                 175     


Arg Ala Glu Asn Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
            180                 185                 190         


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
        195                 200                 205             


Gly Ser Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys 
    210                 215                 220                 


Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys 
225                 230                 235                 240 


Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile 
                245                 250                 255     


Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu 
            260                 265                 270         


Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn 
        275                 280                 285             


Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
    290                 295                 300                 


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
305                 310                 315                 320 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
                325                 330                 335     


His His His 
            


<210>  248
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-8 (23-99) 
       polyprotein.

<400>  248

Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys 
1               5                   10                  15      


Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val 
            20                  25                  30          


Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu 
        35                  40                  45              


Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln 
    50                  55                  60                  


Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser Gly Ser Gly 
65                  70                  75                  80  


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                85                  90                  95      


Ala Gly Ser Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys 
            100                 105                 110         


Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys 
        115                 120                 125             


Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile 
    130                 135                 140                 


Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu 
145                 150                 155                 160 


Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn 
                165                 170                 175     


Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
            180                 185                 190         


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Ala Val 
        195                 200                 205             


Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr 
    210                 215                 220                 


Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu 
225                 230                 235                 240 


Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp 
                245                 250                 255     


Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val 
            260                 265                 270         


Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser Ala Gly Ser Gly Phe 
        275                 280                 285             


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
    290                 295                 300                 


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
305                 310                 315                 320 


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
                325                 330             


<210>  249
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-8 (27-99) 
       polyprotein.

<400>  249

Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys 
1               5                   10                  15      


Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly 
            20                  25                  30          


Pro His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg 
        35                  40                  45              


Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu 
    50                  55                  60                  


Lys Phe Leu Lys Arg Ala Glu Asn Ser Gly Ser Gly Gly Gln Tyr Ile 
65                  70                  75                  80  


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly 
                85                  90                  95      


Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys 
            100                 105                 110         


Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly 
        115                 120                 125             


Pro His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg 
    130                 135                 140                 


Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu 
145                 150                 155                 160 


Lys Phe Leu Lys Arg Ala Glu Asn Ser Ala Gly Ser Gly Phe Asn Asn 
                165                 170                 175     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            180                 185                 190         


Leu Glu Ser Gly Gly Ser Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys 
        195                 200                 205             


Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu 
    210                 215                 220                 


Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val 
225                 230                 235                 240 


Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp 
                245                 250                 255     


Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser Ala 
            260                 265                 270         


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
        275                 280                 285             


Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys 
    290                 295                 300                 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His 
305                 310                 315                 320 


His 
    


<210>  250
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-8 (28-99) 
       polyprotein.

<400>  250

Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro 
1               5                   10                  15      


Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro 
            20                  25                  30          


His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu 
        35                  40                  45              


Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys 
    50                  55                  60                  


Phe Leu Lys Arg Ala Glu Asn Ser Gly Ser Gly Gly Gln Tyr Ile Lys 
65                  70                  75                  80  


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ser 
                85                  90                  95      


Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe 
            100                 105                 110         


His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His 
        115                 120                 125             


Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu 
    130                 135                 140                 


Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe 
145                 150                 155                 160 


Leu Lys Arg Ala Glu Asn Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                165                 170                 175     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            180                 185                 190         


Ser Gly Gly Ser Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr 
        195                 200                 205             


Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile 
    210                 215                 220                 


Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser 
225                 230                 235                 240 


Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg 
                245                 250                 255     


Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser Ala Gly Ser Gly 
            260                 265                 270         


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
        275                 280                 285             


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    290                 295                 300                 


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
305                 310                 315             


<210>  251
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-8 (29-99) 
       polyprotein.

<400>  251

Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe 
1               5                   10                  15      


His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His 
            20                  25                  30          


Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu 
        35                  40                  45              


Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe 
    50                  55                  60                  


Leu Lys Arg Ala Glu Asn Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
65                  70                  75                  80  


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ala Lys 
                85                  90                  95      


Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro 
            100                 105                 110         


Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala 
        115                 120                 125             


Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu 
    130                 135                 140                 


Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys 
145                 150                 155                 160 


Arg Ala Glu Asn Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
                165                 170                 175     


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
            180                 185                 190         


Gly Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys 
        195                 200                 205             


Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly 
    210                 215                 220                 


Pro His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg 
225                 230                 235                 240 


Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu 
                245                 250                 255     


Lys Phe Leu Lys Arg Ala Glu Asn Ser Ala Gly Ser Gly Phe Asn Asn 
            260                 265                 270         


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
        275                 280                 285             


Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
    290                 295                 300                 


Gly Ile Thr Glu Leu His His His His His His 
305                 310                 315 


<210>  252
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-8 (30-99) 
       polyprotein.

<400>  252

Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His 
1               5                   10                  15      


Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys 
            20                  25                  30          


Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys 
        35                  40                  45              


Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu 
    50                  55                  60                  


Lys Arg Ala Glu Asn Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
65                  70                  75                  80  


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Lys Glu Leu 
                85                  90                  95      


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
            100                 105                 110         


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
        115                 120                 125             


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
    130                 135                 140                 


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
145                 150                 155                 160 


Glu Asn Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
                165                 170                 175     


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
            180                 185                 190         


Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His 
        195                 200                 205             


Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys 
    210                 215                 220                 


Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys 
225                 230                 235                 240 


Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu 
                245                 250                 255     


Lys Arg Ala Glu Asn Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
            260                 265                 270         


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
        275                 280                 285             


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
    290                 295                 300                 


Glu Leu His His His His His His 
305                 310         


<210>  253
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-8 (31-99) 
       polyprotein.

<400>  253

Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro 
1               5                   10                  15      


Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala 
            20                  25                  30          


Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu 
        35                  40                  45              


Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys 
    50                  55                  60                  


Arg Ala Glu Asn Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
65                  70                  75                  80  


Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Glu Leu Arg Cys 
                85                  90                  95      


Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys 
            100                 105                 110         


Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile 
        115                 120                 125             


Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu 
    130                 135                 140                 


Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn 
145                 150                 155                 160 


Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
                165                 170                 175     


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Glu Leu 
            180                 185                 190         


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        195                 200                 205             


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    210                 215                 220                 


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
225                 230                 235                 240 


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                245                 250                 255     


Glu Asn Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
            260                 265                 270         


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly 
        275                 280                 285             


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His 
    290                 295                 300                 


His His His His His 
305                 


<210>  254
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-9 polyprotein.

<400>  254

Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile 
1               5                   10                  15      


Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn 
            20                  25                  30          


Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg 
        35                  40                  45              


Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln 
    50                  55                  60                  


Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val 
65                  70                  75                  80  


Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn 
                85                  90                  95      


Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu 
            100                 105                 110         


Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Gly Ser 
        115                 120                 125             


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
    130                 135                 140                 


Leu Ala Gly Ser Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp 
145                 150                 155                 160 


Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys 
                165                 170                 175     


His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser 
            180                 185                 190         


Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr 
        195                 200                 205             


Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys 
    210                 215                 220                 


Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys 
225                 230                 235                 240 


Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu 
                245                 250                 255     


Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg 
            260                 265                 270         


Gly Lys Ile Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
        275                 280                 285             


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
    290                 295                 300                 


Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile 
305                 310                 315                 320 


Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn 
                325                 330                 335     


Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg 
            340                 345                 350         


Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln 
        355                 360                 365             


Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val 
    370                 375                 380                 


Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn 
385                 390                 395                 400 


Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu 
                405                 410                 415     


Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Ala Gly 
            420                 425                 430         


Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
        435                 440                 445             


Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
    450                 455                 460                 


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
465                 470                 475                 480 


<210>  255
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-10 polyprotein.

<400>  255

Ser Arg His Gln Ser Thr Leu Leu Glu Asp Asp Cys Thr His Phe Pro 
1               5                   10                  15      


Ala Ser Leu Pro His Met Leu Arg Glu Leu Arg Ala Ala Phe Gly Arg 
            20                  25                  30          


Val Lys Ile Phe Phe Gln Met Lys Asp Lys Leu Asp Asn Ile Leu Leu 
        35                  40                  45              


Thr Gly Ser Leu Leu Glu Asp Phe Lys Ser Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Arg Ala 
65                  70                  75                  80  


Glu Asn His Asp Pro Asp Ile Lys Asn His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Lys Leu Lys Thr Leu Arg Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
            100                 105                 110         


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
        115                 120                 125             


Ala Phe Ser Lys Leu Gln Glu Lys Gly Val Tyr Lys Ala Met Ser Glu 
    130                 135                 140                 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Thr Tyr Met Thr Met Arg Met 
145                 150                 155                 160 


Lys Ile Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
                165                 170                 175     


Gly Ile Thr Glu Leu Ala Gly Ser Gly Ser Arg His Gln Ser Thr Leu 
            180                 185                 190         


Leu Glu Asp Asp Cys Thr His Phe Pro Ala Ser Leu Pro His Met Leu 
        195                 200                 205             


Arg Glu Leu Arg Ala Ala Phe Gly Arg Val Lys Ile Phe Phe Gln Met 
    210                 215                 220                 


Lys Asp Lys Leu Asp Asn Ile Leu Leu Thr Gly Ser Leu Leu Glu Asp 
225                 230                 235                 240 


Phe Lys Ser Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe 
                245                 250                 255     


Tyr Leu Glu Glu Val Met Pro Arg Ala Glu Asn His Asp Pro Asp Ile 
            260                 265                 270         


Lys Asn His Val Asn Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Leu 
        275                 280                 285             


Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys 
    290                 295                 300                 


Ser Lys Ala Val Glu Gln Val Lys Ser Ala Phe Ser Lys Leu Gln Glu 
305                 310                 315                 320 


Lys Gly Val Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr 
                325                 330                 335     


Ile Glu Thr Tyr Met Thr Met Arg Met Lys Ile Ala Gly Ser Gly Phe 
            340                 345                 350         


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
        355                 360                 365             


Ser His Leu Glu Ser Gly Gly Ser Ser Arg His Gln Ser Thr Leu Leu 
    370                 375                 380                 


Glu Asp Asp Cys Thr His Phe Pro Ala Ser Leu Pro His Met Leu Arg 
385                 390                 395                 400 


Glu Leu Arg Ala Ala Phe Gly Arg Val Lys Ile Phe Phe Gln Met Lys 
                405                 410                 415     


Asp Lys Leu Asp Asn Ile Leu Leu Thr Gly Ser Leu Leu Glu Asp Phe 
            420                 425                 430         


Lys Ser Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr 
        435                 440                 445             


Leu Glu Glu Val Met Pro Arg Ala Glu Asn His Asp Pro Asp Ile Lys 
    450                 455                 460                 


Asn His Val Asn Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Leu Arg 
465                 470                 475                 480 


Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser 
                485                 490                 495     


Lys Ala Val Glu Gln Val Lys Ser Ala Phe Ser Lys Leu Gln Glu Lys 
            500                 505                 510         


Gly Val Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile 
        515                 520                 525             


Glu Thr Tyr Met Thr Met Arg Met Lys Ile Ala Gly Ser Gly Phe Asn 
    530                 535                 540                 


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
545                 550                 555                 560 


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
                565                 570                 575     


Ile Gly Ile Thr Glu Leu His His His His His His 
            580                 585             


<210>  256
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-10 polyprotein.

<400>  256

Ser Arg His Gln Ser Thr Leu Ser Glu Asp Asn Cys Thr His Phe Ser 
1               5                   10                  15      


Val Ser Leu Pro His Met Leu Arg Glu Leu Arg Ala Ala Phe Gly Lys 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu His Ser Ile Leu Leu 
        35                  40                  45              


Thr Arg Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Glu Asp Pro Asp Ile Lys Gln His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Lys Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Val Val Glu Gln Val Lys Ser Thr Phe 
        115                 120                 125             


Ser Lys Leu Gln Glu Lys Gly Val Tyr Lys Ala Met Gly Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Met Lys Ile 
145                 150                 155                 160 


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
                165                 170                 175     


Thr Glu Leu Ala Gly Ser Gly Ser Arg His Gln Ser Thr Leu Ser Glu 
            180                 185                 190         


Asp Asn Cys Thr His Phe Ser Val Ser Leu Pro His Met Leu Arg Glu 
        195                 200                 205             


Leu Arg Ala Ala Phe Gly Lys Val Lys Thr Phe Phe Gln Thr Lys Asp 
    210                 215                 220                 


Glu Leu His Ser Ile Leu Leu Thr Arg Ser Leu Leu Glu Asp Phe Lys 
225                 230                 235                 240 


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
                245                 250                 255     


Glu Glu Val Met Pro Gln Ala Glu Asn Glu Asp Pro Asp Ile Lys Gln 
            260                 265                 270         


His Val Asn Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Leu Arg Leu 
        275                 280                 285             


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Val Val 
    290                 295                 300                 


Glu Gln Val Lys Ser Thr Phe Ser Lys Leu Gln Glu Lys Gly Val Tyr 
305                 310                 315                 320 


Lys Ala Met Gly Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
                325                 330                 335     


Met Thr Met Lys Met Lys Ile Ala Gly Ser Gly Phe Asn Asn Phe Thr 
            340                 345                 350         


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
        355                 360                 365             


Ser Gly Gly Ser Ser Arg His Gln Ser Thr Leu Ser Glu Asp Asn Cys 
    370                 375                 380                 


Thr His Phe Ser Val Ser Leu Pro His Met Leu Arg Glu Leu Arg Ala 
385                 390                 395                 400 


Ala Phe Gly Lys Val Lys Thr Phe Phe Gln Thr Lys Asp Glu Leu His 
                405                 410                 415     


Ser Ile Leu Leu Thr Arg Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
            420                 425                 430         


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
        435                 440                 445             


Met Pro Gln Ala Glu Asn Glu Asp Pro Asp Ile Lys Gln His Val Asn 
    450                 455                 460                 


Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
465                 470                 475                 480 


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Val Val Glu Gln Val 
                485                 490                 495     


Lys Ser Thr Phe Ser Lys Leu Gln Glu Lys Gly Val Tyr Lys Ala Met 
            500                 505                 510         


Gly Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met 
        515                 520                 525             


Lys Met Lys Ile Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
    530                 535                 540                 


Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly 
545                 550                 555                 560 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                565                 570                 575     


His His His His His His 
            580         


<210>  257
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-10 polyprotein.

<400>  257

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
                165                 170                 175     


Thr Glu Leu Ala Gly Ser Gly Ser Pro Gly Gln Gly Thr Gln Ser Glu 
            180                 185                 190         


Asn Ser Cys Thr His Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp 
        195                 200                 205             


Leu Arg Asp Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp 
    210                 215                 220                 


Gln Leu Asp Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys 
225                 230                 235                 240 


Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu 
                245                 250                 255     


Glu Glu Val Met Pro Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala 
            260                 265                 270         


His Val Asn Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu 
        275                 280                 285             


Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val 
    290                 295                 300                 


Glu Gln Val Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr 
305                 310                 315                 320 


Lys Ala Met Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr 
                325                 330                 335     


Met Thr Met Lys Ile Arg Asn Ala Gly Ser Gly Phe Asn Asn Phe Thr 
            340                 345                 350         


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
        355                 360                 365             


Ser Gly Gly Ser Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys 
    370                 375                 380                 


Thr His Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp 
385                 390                 395                 400 


Ala Phe Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp 
                405                 410                 415     


Asn Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu 
            420                 425                 430         


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val 
        435                 440                 445             


Met Pro Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn 
    450                 455                 460                 


Ser Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys 
465                 470                 475                 480 


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val 
                485                 490                 495     


Lys Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met 
            500                 505                 510         


Ser Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met 
        515                 520                 525             


Lys Ile Arg Asn Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
    530                 535                 540                 


Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly 
545                 550                 555                 560 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                565                 570                 575     


His His His His His His 
            580         


<210>  258
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-11 polyprotein.

<400>  258

Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser Pro Asp Pro Arg Ala 
1               5                   10                  15      


Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser Leu Leu Ala Asp Thr 
            20                  25                  30          


Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe Pro Ala Asp Gly Asp 
        35                  40                  45              


His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met Ser Ala Gly Ala Leu 
    50                  55                  60                  


Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg Leu Arg Ala Asp Leu 
65                  70                  75                  80  


Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg Arg Ala Gly Gly Ser 
                85                  90                  95      


Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr Leu Gln Ala Arg Leu 
            100                 105                 110         


Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met Ser Arg Leu Ala Leu 
        115                 120                 125             


Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro Leu Ala Pro Pro Ser 
    130                 135                 140                 


Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala Ile Leu Gly Gly Leu 
145                 150                 155                 160 


His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu Leu Leu Leu Lys Thr 
                165                 170                 175     


Arg Leu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
            180                 185                 190         


Gly Ile Thr Glu Leu Ala Gly Ser Gly Pro Gly Pro Pro Pro Gly Pro 
        195                 200                 205             


Pro Arg Val Ser Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu 
    210                 215                 220                 


Leu Thr Arg Ser Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Leu 
225                 230                 235                 240 


Arg Asp Lys Phe Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro 
                245                 250                 255     


Thr Leu Ala Met Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly 
            260                 265                 270         


Val Leu Thr Arg Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val 
        275                 280                 285             


Gln Trp Leu Arg Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro 
    290                 295                 300                 


Glu Leu Gly Thr Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu 
305                 310                 315                 320 


Gln Leu Leu Met Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro 
                325                 330                 335     


Pro Ala Pro Pro Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg 
            340                 345                 350         


Ala Ala His Ala Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala 
        355                 360                 365             


Val Arg Gly Leu Leu Leu Leu Lys Thr Arg Leu Ala Gly Ser Gly Phe 
    370                 375                 380                 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
385                 390                 395                 400 


Ser His Leu Glu Ser Gly Gly Ser Pro Gly Pro Pro Pro Gly Pro Pro 
                405                 410                 415     


Arg Val Ser Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu Leu 
            420                 425                 430         


Thr Arg Ser Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Leu Arg 
        435                 440                 445             


Asp Lys Phe Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr 
    450                 455                 460                 


Leu Ala Met Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val 
465                 470                 475                 480 


Leu Thr Arg Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln 
                485                 490                 495     


Trp Leu Arg Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu 
            500                 505                 510         


Leu Gly Thr Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln 
        515                 520                 525             


Leu Leu Met Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro 
    530                 535                 540                 


Ala Pro Pro Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala 
545                 550                 555                 560 


Ala His Ala Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val 
                565                 570                 575     


Arg Gly Leu Leu Leu Leu Lys Thr Arg Leu Ala Gly Ser Gly Phe Asn 
            580                 585                 590         


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
        595                 600                 605             


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
    610                 615                 620                 


Ile Gly Ile Thr Glu Leu His His His His His His 
625                 630                 635     


<210>  259
<211>  1740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-14 polyprotein.

<400>  259

Met Lys Asn Gln Asp Lys Lys Asn Gly Ala Ala Lys Gln Ser Asn Pro 
1               5                   10                  15      


Lys Ser Ser Pro Gly Gln Pro Glu Ala Gly Pro Glu Gly Ala Gln Glu 
            20                  25                  30          


Arg Pro Ser Gln Ala Ala Pro Ala Val Glu Ala Glu Gly Pro Gly Ser 
        35                  40                  45              


Ser Gln Ala Pro Arg Lys Pro Glu Gly Ala Gln Ala Arg Thr Ala Gln 
    50                  55                  60                  


Ser Gly Ala Leu Arg Asp Val Ser Glu Glu Leu Ser Arg Gln Leu Glu 
65                  70                  75                  80  


Asp Ile Leu Ser Thr Tyr Cys Val Asp Asn Asn Gln Gly Gly Pro Gly 
                85                  90                  95      


Glu Asp Gly Ala Gln Gly Glu Pro Ala Glu Pro Glu Asp Ala Glu Lys 
            100                 105                 110         


Ser Arg Thr Tyr Val Ala Arg Asn Gly Glu Pro Glu Pro Thr Pro Val 
        115                 120                 125             


Val Asn Gly Glu Lys Glu Pro Ser Lys Gly Asp Pro Asn Thr Glu Glu 
    130                 135                 140                 


Ile Arg Gln Ser Asp Glu Val Gly Asp Arg Asp His Arg Arg Pro Gln 
145                 150                 155                 160 


Glu Lys Lys Lys Ala Lys Gly Leu Gly Lys Glu Ile Thr Leu Leu Met 
                165                 170                 175     


Gln Thr Leu Asn Thr Leu Ser Thr Pro Glu Glu Lys Leu Ala Ala Leu 
            180                 185                 190         


Cys Lys Lys Tyr Ala Glu Leu Leu Glu Glu His Arg Asn Ser Gln Lys 
        195                 200                 205             


Gln Met Lys Leu Leu Gln Lys Lys Gln Ser Gln Leu Val Gln Glu Lys 
    210                 215                 220                 


Asp His Leu Arg Gly Glu His Ser Lys Ala Val Leu Ala Arg Ser Lys 
225                 230                 235                 240 


Leu Glu Ser Leu Cys Arg Glu Leu Gln Arg His Asn Arg Ser Leu Lys 
                245                 250                 255     


Glu Glu Gly Val Gln Arg Ala Arg Glu Glu Glu Glu Lys Arg Lys Glu 
            260                 265                 270         


Val Thr Ser His Phe Gln Val Thr Leu Asn Asp Ile Gln Leu Gln Met 
        275                 280                 285             


Glu Gln His Asn Glu Arg Asn Ser Lys Leu Arg Gln Glu Asn Met Glu 
    290                 295                 300                 


Leu Ala Glu Arg Leu Lys Lys Leu Ile Glu Gln Tyr Glu Leu Arg Glu 
305                 310                 315                 320 


Glu His Ile Asp Lys Val Phe Lys His Lys Asp Leu Gln Gln Gln Leu 
                325                 330                 335     


Val Asp Ala Lys Leu Gln Gln Ala Gln Glu Met Leu Lys Glu Ala Glu 
            340                 345                 350         


Glu Arg His Gln Arg Glu Lys Asp Phe Leu Leu Lys Glu Ala Val Glu 
        355                 360                 365             


Ser Gln Arg Met Cys Glu Leu Met Lys Gln Gln Glu Thr His Leu Lys 
    370                 375                 380                 


Gln Gln Leu Ala Leu Tyr Thr Glu Lys Phe Glu Glu Phe Gln Asn Thr 
385                 390                 395                 400 


Leu Ser Lys Ser Ser Glu Val Phe Thr Thr Phe Lys Gln Glu Met Glu 
                405                 410                 415     


Lys Met Thr Lys Lys Ile Lys Lys Leu Glu Lys Glu Thr Thr Met Tyr 
            420                 425                 430         


Arg Ser Arg Trp Glu Ser Ser Asn Lys Ala Leu Leu Glu Met Ala Glu 
        435                 440                 445             


Glu Lys Thr Val Arg Asp Lys Glu Leu Glu Gly Leu Gln Val Lys Ile 
    450                 455                 460                 


Gln Arg Leu Glu Lys Leu Cys Arg Ala Leu Gln Thr Glu Arg Asn Asp 
465                 470                 475                 480 


Leu Asn Lys Arg Val Gln Asp Leu Ser Ala Gly Gly Gln Gly Ser Leu 
                485                 490                 495     


Thr Asp Ser Gly Pro Glu Arg Arg Pro Glu Gly Pro Gly Ala Gln Ala 
            500                 505                 510         


Pro Ser Ser Pro Arg Val Thr Glu Ala Pro Cys Tyr Pro Gly Ala Pro 
        515                 520                 525             


Ser Thr Glu Ala Ser Gly Gln Thr Gly Pro Gln Glu Pro Thr Ser Ala 
    530                 535                 540                 


Arg Ala Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
545                 550                 555                 560 


Gly Ile Thr Glu Leu Ala Gly Ser Gly Met Lys Asn Gln Asp Lys Lys 
                565                 570                 575     


Asn Gly Ala Ala Lys Gln Ser Asn Pro Lys Ser Ser Pro Gly Gln Pro 
            580                 585                 590         


Glu Ala Gly Pro Glu Gly Ala Gln Glu Arg Pro Ser Gln Ala Ala Pro 
        595                 600                 605             


Ala Val Glu Ala Glu Gly Pro Gly Ser Ser Gln Ala Pro Arg Lys Pro 
    610                 615                 620                 


Glu Gly Ala Gln Ala Arg Thr Ala Gln Ser Gly Ala Leu Arg Asp Val 
625                 630                 635                 640 


Ser Glu Glu Leu Ser Arg Gln Leu Glu Asp Ile Leu Ser Thr Tyr Cys 
                645                 650                 655     


Val Asp Asn Asn Gln Gly Gly Pro Gly Glu Asp Gly Ala Gln Gly Glu 
            660                 665                 670         


Pro Ala Glu Pro Glu Asp Ala Glu Lys Ser Arg Thr Tyr Val Ala Arg 
        675                 680                 685             


Asn Gly Glu Pro Glu Pro Thr Pro Val Val Asn Gly Glu Lys Glu Pro 
    690                 695                 700                 


Ser Lys Gly Asp Pro Asn Thr Glu Glu Ile Arg Gln Ser Asp Glu Val 
705                 710                 715                 720 


Gly Asp Arg Asp His Arg Arg Pro Gln Glu Lys Lys Lys Ala Lys Gly 
                725                 730                 735     


Leu Gly Lys Glu Ile Thr Leu Leu Met Gln Thr Leu Asn Thr Leu Ser 
            740                 745                 750         


Thr Pro Glu Glu Lys Leu Ala Ala Leu Cys Lys Lys Tyr Ala Glu Leu 
        755                 760                 765             


Leu Glu Glu His Arg Asn Ser Gln Lys Gln Met Lys Leu Leu Gln Lys 
    770                 775                 780                 


Lys Gln Ser Gln Leu Val Gln Glu Lys Asp His Leu Arg Gly Glu His 
785                 790                 795                 800 


Ser Lys Ala Val Leu Ala Arg Ser Lys Leu Glu Ser Leu Cys Arg Glu 
                805                 810                 815     


Leu Gln Arg His Asn Arg Ser Leu Lys Glu Glu Gly Val Gln Arg Ala 
            820                 825                 830         


Arg Glu Glu Glu Glu Lys Arg Lys Glu Val Thr Ser His Phe Gln Val 
        835                 840                 845             


Thr Leu Asn Asp Ile Gln Leu Gln Met Glu Gln His Asn Glu Arg Asn 
    850                 855                 860                 


Ser Lys Leu Arg Gln Glu Asn Met Glu Leu Ala Glu Arg Leu Lys Lys 
865                 870                 875                 880 


Leu Ile Glu Gln Tyr Glu Leu Arg Glu Glu His Ile Asp Lys Val Phe 
                885                 890                 895     


Lys His Lys Asp Leu Gln Gln Gln Leu Val Asp Ala Lys Leu Gln Gln 
            900                 905                 910         


Ala Gln Glu Met Leu Lys Glu Ala Glu Glu Arg His Gln Arg Glu Lys 
        915                 920                 925             


Asp Phe Leu Leu Lys Glu Ala Val Glu Ser Gln Arg Met Cys Glu Leu 
    930                 935                 940                 


Met Lys Gln Gln Glu Thr His Leu Lys Gln Gln Leu Ala Leu Tyr Thr 
945                 950                 955                 960 


Glu Lys Phe Glu Glu Phe Gln Asn Thr Leu Ser Lys Ser Ser Glu Val 
                965                 970                 975     


Phe Thr Thr Phe Lys Gln Glu Met Glu Lys Met Thr Lys Lys Ile Lys 
            980                 985                 990         


Lys Leu Glu Lys Glu Thr Thr Met  Tyr Arg Ser Arg Trp  Glu Ser Ser 
        995                 1000                 1005             


Asn Lys  Ala Leu Leu Glu Met  Ala Glu Glu Lys Thr  Val Arg Asp 
    1010                 1015                 1020             


Lys Glu  Leu Glu Gly Leu Gln  Val Lys Ile Gln Arg  Leu Glu Lys 
    1025                 1030                 1035             


Leu Cys  Arg Ala Leu Gln Thr  Glu Arg Asn Asp Leu  Asn Lys Arg 
    1040                 1045                 1050             


Val Gln  Asp Leu Ser Ala Gly  Gly Gln Gly Ser Leu  Thr Asp Ser 
    1055                 1060                 1065             


Gly Pro  Glu Arg Arg Pro Glu  Gly Pro Gly Ala Gln  Ala Pro Ser 
    1070                 1075                 1080             


Ser Pro  Arg Val Thr Glu Ala  Pro Cys Tyr Pro Gly  Ala Pro Ser 
    1085                 1090                 1095             


Thr Glu  Ala Ser Gly Gln Thr  Gly Pro Gln Glu Pro  Thr Ser Ala 
    1100                 1105                 1110             


Arg Ala  Ala Gly Ser Gly Phe  Asn Asn Phe Thr Val  Ser Phe Trp 
    1115                 1120                 1125             


Leu Arg  Val Pro Lys Val Ser  Ala Ser His Leu Glu  Ser Gly Gly 
    1130                 1135                 1140             


Ser Met  Lys Asn Gln Asp Lys  Lys Asn Gly Ala Ala  Lys Gln Ser 
    1145                 1150                 1155             


Asn Pro  Lys Ser Ser Pro Gly  Gln Pro Glu Ala Gly  Pro Glu Gly 
    1160                 1165                 1170             


Ala Gln  Glu Arg Pro Ser Gln  Ala Ala Pro Ala Val  Glu Ala Glu 
    1175                 1180                 1185             


Gly Pro  Gly Ser Ser Gln Ala  Pro Arg Lys Pro Glu  Gly Ala Gln 
    1190                 1195                 1200             


Ala Arg  Thr Ala Gln Ser Gly  Ala Leu Arg Asp Val  Ser Glu Glu 
    1205                 1210                 1215             


Leu Ser  Arg Gln Leu Glu Asp  Ile Leu Ser Thr Tyr  Cys Val Asp 
    1220                 1225                 1230             


Asn Asn  Gln Gly Gly Pro Gly  Glu Asp Gly Ala Gln  Gly Glu Pro 
    1235                 1240                 1245             


Ala Glu  Pro Glu Asp Ala Glu  Lys Ser Arg Thr Tyr  Val Ala Arg 
    1250                 1255                 1260             


Asn Gly  Glu Pro Glu Pro Thr  Pro Val Val Asn Gly  Glu Lys Glu 
    1265                 1270                 1275             


Pro Ser  Lys Gly Asp Pro Asn  Thr Glu Glu Ile Arg  Gln Ser Asp 
    1280                 1285                 1290             


Glu Val  Gly Asp Arg Asp His  Arg Arg Pro Gln Glu  Lys Lys Lys 
    1295                 1300                 1305             


Ala Lys  Gly Leu Gly Lys Glu  Ile Thr Leu Leu Met  Gln Thr Leu 
    1310                 1315                 1320             


Asn Thr  Leu Ser Thr Pro Glu  Glu Lys Leu Ala Ala  Leu Cys Lys 
    1325                 1330                 1335             


Lys Tyr  Ala Glu Leu Leu Glu  Glu His Arg Asn Ser  Gln Lys Gln 
    1340                 1345                 1350             


Met Lys  Leu Leu Gln Lys Lys  Gln Ser Gln Leu Val  Gln Glu Lys 
    1355                 1360                 1365             


Asp His  Leu Arg Gly Glu His  Ser Lys Ala Val Leu  Ala Arg Ser 
    1370                 1375                 1380             


Lys Leu  Glu Ser Leu Cys Arg  Glu Leu Gln Arg His  Asn Arg Ser 
    1385                 1390                 1395             


Leu Lys  Glu Glu Gly Val Gln  Arg Ala Arg Glu Glu  Glu Glu Lys 
    1400                 1405                 1410             


Arg Lys  Glu Val Thr Ser His  Phe Gln Val Thr Leu  Asn Asp Ile 
    1415                 1420                 1425             


Gln Leu  Gln Met Glu Gln His  Asn Glu Arg Asn Ser  Lys Leu Arg 
    1430                 1435                 1440             


Gln Glu  Asn Met Glu Leu Ala  Glu Arg Leu Lys Lys  Leu Ile Glu 
    1445                 1450                 1455             


Gln Tyr  Glu Leu Arg Glu Glu  His Ile Asp Lys Val  Phe Lys His 
    1460                 1465                 1470             


Lys Asp  Leu Gln Gln Gln Leu  Val Asp Ala Lys Leu  Gln Gln Ala 
    1475                 1480                 1485             


Gln Glu  Met Leu Lys Glu Ala  Glu Glu Arg His Gln  Arg Glu Lys 
    1490                 1495                 1500             


Asp Phe  Leu Leu Lys Glu Ala  Val Glu Ser Gln Arg  Met Cys Glu 
    1505                 1510                 1515             


Leu Met  Lys Gln Gln Glu Thr  His Leu Lys Gln Gln  Leu Ala Leu 
    1520                 1525                 1530             


Tyr Thr  Glu Lys Phe Glu Glu  Phe Gln Asn Thr Leu  Ser Lys Ser 
    1535                 1540                 1545             


Ser Glu  Val Phe Thr Thr Phe  Lys Gln Glu Met Glu  Lys Met Thr 
    1550                 1555                 1560             


Lys Lys  Ile Lys Lys Leu Glu  Lys Glu Thr Thr Met  Tyr Arg Ser 
    1565                 1570                 1575             


Arg Trp  Glu Ser Ser Asn Lys  Ala Leu Leu Glu Met  Ala Glu Glu 
    1580                 1585                 1590             


Lys Thr  Val Arg Asp Lys Glu  Leu Glu Gly Leu Gln  Val Lys Ile 
    1595                 1600                 1605             


Gln Arg  Leu Glu Lys Leu Cys  Arg Ala Leu Gln Thr  Glu Arg Asn 
    1610                 1615                 1620             


Asp Leu  Asn Lys Arg Val Gln  Asp Leu Ser Ala Gly  Gly Gln Gly 
    1625                 1630                 1635             


Ser Leu  Thr Asp Ser Gly Pro  Glu Arg Arg Pro Glu  Gly Pro Gly 
    1640                 1645                 1650             


Ala Gln  Ala Pro Ser Ser Pro  Arg Val Thr Glu Ala  Pro Cys Tyr 
    1655                 1660                 1665             


Pro Gly  Ala Pro Ser Thr Glu  Ala Ser Gly Gln Thr  Gly Pro Gln 
    1670                 1675                 1680             


Glu Pro  Thr Ser Ala Arg Ala  Ala Gly Ser Gly Phe  Asn Asn Phe 
    1685                 1690                 1695             


Thr Val  Ser Phe Trp Leu Arg  Val Pro Lys Val Ser  Ala Ser His 
    1700                 1705                 1710             


Leu Glu  Gly Ser Gly Gly Gln  Tyr Ile Lys Ala Asn  Ser Lys Phe 
    1715                 1720                 1725             


Ile Gly  Ile Thr Glu Leu His  His His His His His  
    1730                 1735                 1740 


<210>  260
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-15 polyprotein.

<400>  260

Asn Trp Gln Asp Val Ile Ser Asp Leu Lys Ile Ile Asp Lys Ile Ile 
1               5                   10                  15      


Gln Ser Leu His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Asn Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu His 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Lys Asn Glu Thr Ile His Gln Thr Val Glu 
    50                  55                  60                  


Asn Ile Ile Ile Leu Ala Asn Ser Gly Leu Ser Ser Asn Arg Asn Ile 
65                  70                  75                  80  


Thr Glu Thr Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
        115                 120                 125             


Gly Ile Thr Glu Leu Ala Gly Ser Gly Asn Trp Gln Asp Val Ile Ser 
    130                 135                 140                 


Asp Leu Lys Ile Ile Asp Lys Ile Ile Gln Ser Leu His Ile Asp Ala 
145                 150                 155                 160 


Thr Leu Tyr Thr Glu Ser Asp Val His Pro Asn Cys Lys Val Thr Ala 
                165                 170                 175     


Met Lys Cys Phe Leu Leu Glu Leu His Val Ile Ser Leu Glu Ser Lys 
            180                 185                 190         


Asn Glu Thr Ile His Gln Thr Val Glu Asn Ile Ile Ile Leu Ala Asn 
        195                 200                 205             


Ser Gly Leu Ser Ser Asn Arg Asn Ile Thr Glu Thr Gly Cys Lys Glu 
    210                 215                 220                 


Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
225                 230                 235                 240 


Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ala Gly Ser Gly Phe 
                245                 250                 255     


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
            260                 265                 270         


Ser His Leu Glu Ser Gly Gly Ser Asn Trp Gln Asp Val Ile Ser Asp 
        275                 280                 285             


Leu Lys Ile Ile Asp Lys Ile Ile Gln Ser Leu His Ile Asp Ala Thr 
    290                 295                 300                 


Leu Tyr Thr Glu Ser Asp Val His Pro Asn Cys Lys Val Thr Ala Met 
305                 310                 315                 320 


Lys Cys Phe Leu Leu Glu Leu His Val Ile Ser Leu Glu Ser Lys Asn 
                325                 330                 335     


Glu Thr Ile His Gln Thr Val Glu Asn Ile Ile Ile Leu Ala Asn Ser 
            340                 345                 350         


Gly Leu Ser Ser Asn Arg Asn Ile Thr Glu Thr Gly Cys Lys Glu Cys 
        355                 360                 365             


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
    370                 375                 380                 


His Ile Val Gln Met Phe Ile Asn Thr Ser Ala Gly Ser Gly Phe Asn 
385                 390                 395                 400 


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
                405                 410                 415     


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
            420                 425                 430         


Ile Gly Ile Thr Glu Leu His His His His His His 
        435                 440                 


<210>  261
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-15 polyprotein.

<400>  261

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
        115                 120                 125             


Gly Ile Thr Glu Leu Ala Gly Ser Gly Asn Trp Val Asn Val Ile Ser 
    130                 135                 140                 


Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
145                 150                 155                 160 


Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
                165                 170                 175     


Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
            180                 185                 190         


Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn 
        195                 200                 205             


Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu 
    210                 215                 220                 


Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
225                 230                 235                 240 


Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ala Gly Ser Gly Phe 
                245                 250                 255     


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
            260                 265                 270         


Ser His Leu Glu Ser Gly Gly Ser Asn Trp Val Asn Val Ile Ser Asp 
        275                 280                 285             


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
    290                 295                 300                 


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
305                 310                 315                 320 


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
                325                 330                 335     


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
            340                 345                 350         


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
        355                 360                 365             


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
    370                 375                 380                 


His Ile Val Gln Met Phe Ile Asn Thr Ser Ala Gly Ser Gly Phe Asn 
385                 390                 395                 400 


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
                405                 410                 415     


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
            420                 425                 430         


Ile Gly Ile Thr Glu Leu His His His His His His 
        435                 440                 


<210>  262
<211>  4098
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-16 (1-1332) 
       polyprotein.

<400>  262

Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      


Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          


Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              


Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  


Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      


Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         


Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             


Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 


Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     


Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         


Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             


Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 


Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 


Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     


Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         


Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             


Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 


Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 


Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     


Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         


Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             


Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 


His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 


Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     


Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 
            420                 425                 430         


Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             


Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 


Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 


Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     


Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         


Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             


Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 


Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 


Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     


Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 
            580                 585                 590         


Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 
        595                 600                 605             


Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 
    610                 615                 620                 


Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 
625                 630                 635                 640 


Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 
                645                 650                 655     


Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 
            660                 665                 670         


Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 
        675                 680                 685             


Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 
    690                 695                 700                 


Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 
705                 710                 715                 720 


Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 
                725                 730                 735     


Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 
            740                 745                 750         


His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 
        755                 760                 765             


Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 
    770                 775                 780                 


Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 
                805                 810                 815     


Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 
            820                 825                 830         


Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 
        835                 840                 845             


Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 
    850                 855                 860                 


Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 
865                 870                 875                 880 


Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 
                885                 890                 895     


Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 
            900                 905                 910         


Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 
        915                 920                 925             


Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 
    930                 935                 940                 


Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 
945                 950                 955                 960 


Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 
                965                 970                 975     


Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 
            980                 985                 990         


Gln Val Ser Ser Ala Val Met Lys  Ser Leu Leu Cys Leu  Pro Ser Ser 
        995                 1000                 1005             


Ile Ser  Cys Ala Gln Thr Pro  Cys Ile Pro Lys Glu  Gly Ala Ser 
    1010                 1015                 1020             


Pro Thr  Ser Ser Ser Asn Glu  Asp Ser Ala Ala Asn  Gly Ser Ala 
    1025                 1030                 1035             


Glu Thr  Ser Ala Leu Asp Thr  Gly Phe Ser Leu Asn  Leu Ser Glu 
    1040                 1045                 1050             


Leu Arg  Glu Tyr Thr Glu Gly  Leu Thr Glu Ala Lys  Glu Asp Asp 
    1055                 1060                 1065             


Asp Gly  Asp His Ser Ser Leu  Gln Ser Gly Gln Ser  Val Ile Ser 
    1070                 1075                 1080             


Leu Leu  Ser Ser Glu Glu Leu  Lys Lys Leu Ile Glu  Glu Val Lys 
    1085                 1090                 1095             


Val Leu  Asp Glu Ala Thr Leu  Lys Gln Leu Asp Gly  Ile His Val 
    1100                 1105                 1110             


Thr Ile  Leu His Lys Glu Glu  Gly Ala Gly Leu Gly  Phe Ser Leu 
    1115                 1120                 1125             


Ala Gly  Gly Ala Asp Leu Glu  Asn Lys Val Ile Thr  Val His Arg 
    1130                 1135                 1140             


Val Phe  Pro Asn Gly Leu Ala  Ser Gln Glu Gly Thr  Ile Gln Lys 
    1145                 1150                 1155             


Gly Asn  Glu Val Leu Ser Ile  Asn Gly Lys Ser Leu  Lys Gly Thr 
    1160                 1165                 1170             


Thr His  His Asp Ala Leu Ala  Ile Leu Arg Gln Ala  Arg Glu Pro 
    1175                 1180                 1185             


Arg Gln  Ala Val Ile Val Thr  Arg Lys Leu Thr Pro  Glu Ala Met 
    1190                 1195                 1200             


Pro Asp  Leu Asn Ser Ser Thr  Asp Ser Ala Ala Ser  Ala Ser Ala 
    1205                 1210                 1215             


Ala Ser  Asp Val Ser Val Glu  Ser Thr Ala Glu Ala  Thr Val Cys 
    1220                 1225                 1230             


Thr Val  Thr Leu Glu Lys Met  Ser Ala Gly Leu Gly  Phe Ser Leu 
    1235                 1240                 1245             


Glu Gly  Gly Lys Gly Ser Leu  His Gly Asp Lys Pro  Leu Thr Ile 
    1250                 1255                 1260             


Asn Arg  Ile Phe Lys Gly Ala  Ala Ser Glu Gln Ser  Glu Thr Val 
    1265                 1270                 1275             


Gln Pro  Gly Asp Glu Ile Leu  Gln Leu Gly Gly Thr  Ala Met Gln 
    1280                 1285                 1290             


Gly Leu  Thr Arg Phe Glu Ala  Trp Asn Ile Ile Lys  Ala Leu Pro 
    1295                 1300                 1305             


Asp Gly  Pro Val Thr Ile Val  Ile Arg Arg Lys Ser  Leu Gln Ser 
    1310                 1315                 1320             


Lys Glu  Thr Thr Ala Ala Gly  Asp Ser Gly Ser Gly  Gly Gln Tyr 
    1325                 1330                 1335             


Ile Lys  Ala Asn Ser Lys Phe  Ile Gly Ile Thr Glu  Leu Ala Gly 
    1340                 1345                 1350             


Ser Gly  Met Glu Ser His Ser  Arg Ala Gly Lys Ser  Arg Lys Ser 
    1355                 1360                 1365             


Ala Lys  Phe Arg Ser Ile Ser  Arg Ser Leu Met Leu  Cys Asn Ala 
    1370                 1375                 1380             


Lys Thr  Ser Asp Asp Gly Ser  Ser Pro Asp Glu Lys  Tyr Pro Asp 
    1385                 1390                 1395             


Pro Phe  Glu Ile Ser Leu Ala  Gln Gly Lys Glu Gly  Ile Phe His 
    1400                 1405                 1410             


Ser Ser  Val Gln Leu Ala Asp  Thr Ser Glu Ala Gly  Pro Ser Ser 
    1415                 1420                 1425             


Val Pro  Asp Leu Ala Leu Ala  Ser Glu Ala Ala Gln  Leu Gln Ala 
    1430                 1435                 1440             


Ala Gly  Asn Asp Arg Gly Lys  Thr Cys Arg Arg Ile  Phe Phe Met 
    1445                 1450                 1455             


Lys Glu  Ser Ser Thr Ala Ser  Ser Arg Glu Lys Pro  Gly Lys Leu 
    1460                 1465                 1470             


Glu Ala  Gln Ser Ser Asn Phe  Leu Phe Pro Lys Ala  Cys His Gln 
    1475                 1480                 1485             


Arg Ala  Arg Ser Asn Ser Thr  Ser Val Asn Pro Tyr  Cys Thr Arg 
    1490                 1495                 1500             


Glu Ile  Asp Phe Pro Met Thr  Lys Lys Ser Ala Ala  Pro Thr Asp 
    1505                 1510                 1515             


Arg Gln  Pro Tyr Ser Leu Cys  Ser Asn Arg Lys Ser  Leu Ser Gln 
    1520                 1525                 1530             


Gln Leu  Asp Cys Pro Ala Gly  Lys Ala Ala Gly Thr  Ser Arg Pro 
    1535                 1540                 1545             


Thr Arg  Ser Leu Ser Thr Ala  Gln Leu Val Gln Pro  Ser Gly Gly 
    1550                 1555                 1560             


Leu Gln  Ala Ser Val Ile Ser  Asn Ile Val Leu Met  Lys Gly Gln 
    1565                 1570                 1575             


Ala Lys  Gly Leu Gly Phe Ser  Ile Val Gly Gly Lys  Asp Ser Ile 
    1580                 1585                 1590             


Tyr Gly  Pro Ile Gly Ile Tyr  Val Lys Thr Ile Phe  Ala Gly Gly 
    1595                 1600                 1605             


Ala Ala  Ala Ala Asp Gly Arg  Leu Gln Glu Gly Asp  Glu Ile Leu 
    1610                 1615                 1620             


Glu Leu  Asn Gly Glu Ser Met  Ala Gly Leu Thr His  Gln Asp Ala 
    1625                 1630                 1635             


Leu Gln  Lys Phe Lys Gln Ala  Lys Lys Gly Leu Leu  Thr Leu Thr 
    1640                 1645                 1650             


Val Arg  Thr Arg Leu Thr Ala  Pro Pro Ser Leu Cys  Ser His Leu 
    1655                 1660                 1665             


Ser Pro  Pro Leu Cys Arg Ser  Leu Ser Ser Ser Thr  Cys Ile Thr 
    1670                 1675                 1680             


Lys Asp  Ser Ser Ser Phe Ala  Leu Glu Ser Pro Ser  Ala Pro Ile 
    1685                 1690                 1695             


Ser Thr  Ala Lys Pro Asn Tyr  Arg Ile Met Val Glu  Val Ser Leu 
    1700                 1705                 1710             


Gln Lys  Glu Ala Gly Val Gly  Leu Gly Ile Gly Leu  Cys Ser Val 
    1715                 1720                 1725             


Pro Tyr  Phe Gln Cys Ile Ser  Gly Ile Phe Val His  Thr Leu Ser 
    1730                 1735                 1740             


Pro Gly  Ser Val Ala His Leu  Asp Gly Arg Leu Arg  Cys Gly Asp 
    1745                 1750                 1755             


Glu Ile  Val Glu Ile Ser Asp  Ser Pro Val His Cys  Leu Thr Leu 
    1760                 1765                 1770             


Asn Glu  Val Tyr Thr Ile Leu  Ser His Cys Asp Pro  Gly Pro Val 
    1775                 1780                 1785             


Pro Ile  Ile Val Ser Arg His  Pro Asp Pro Gln Val  Ser Glu Gln 
    1790                 1795                 1800             


Gln Leu  Lys Glu Ala Val Ala  Gln Ala Val Glu Asn  Thr Lys Phe 
    1805                 1810                 1815             


Gly Lys  Glu Arg His Gln Trp  Ser Leu Glu Gly Val  Lys Arg Leu 
    1820                 1825                 1830             


Glu Ser  Ser Trp His Gly Arg  Pro Thr Leu Glu Lys  Glu Arg Glu 
    1835                 1840                 1845             


Lys Asn  Ser Ala Pro Pro His  Arg Arg Ala Gln Lys  Val Met Ile 
    1850                 1855                 1860             


Arg Ser  Ser Ser Asp Ser Ser  Tyr Met Ser Gly Ser  Pro Gly Gly 
    1865                 1870                 1875             


Ser Pro  Gly Ser Gly Ser Ala  Glu Lys Pro Ser Ser  Asp Val Asp 
    1880                 1885                 1890             


Ile Ser  Thr His Ser Pro Ser  Leu Pro Leu Ala Arg  Glu Pro Val 
    1895                 1900                 1905             


Val Leu  Ser Ile Ala Ser Ser  Arg Leu Pro Gln Glu  Ser Pro Pro 
    1910                 1915                 1920             


Leu Pro  Glu Ser Arg Asp Ser  His Pro Pro Leu Arg  Leu Lys Lys 
    1925                 1930                 1935             


Ser Phe  Glu Ile Leu Val Arg  Lys Pro Met Ser Ser  Lys Pro Lys 
    1940                 1945                 1950             


Pro Pro  Pro Arg Lys Tyr Phe  Lys Ser Asp Ser Asp  Pro Gln Lys 
    1955                 1960                 1965             


Ser Leu  Glu Glu Arg Glu Asn  Ser Ser Cys Ser Ser  Gly His Thr 
    1970                 1975                 1980             


Pro Pro  Thr Cys Gly Gln Glu  Ala Arg Glu Leu Leu  Pro Leu Leu 
    1985                 1990                 1995             


Leu Pro  Gln Glu Asp Thr Ala  Gly Arg Ser Pro Ser  Ala Ser Ala 
    2000                 2005                 2010             


Gly Cys  Pro Gly Pro Gly Ile  Gly Pro Gln Thr Lys  Ser Ser Thr 
    2015                 2020                 2025             


Glu Gly  Glu Pro Gly Trp Arg  Arg Ala Ser Pro Val  Thr Gln Thr 
    2030                 2035                 2040             


Ser Pro  Ile Lys His Pro Leu  Leu Lys Arg Gln Ala  Arg Met Asp 
    2045                 2050                 2055             


Tyr Ser  Phe Asp Thr Thr Ala  Glu Asp Pro Trp Val  Arg Ile Ser 
    2060                 2065                 2070             


Asp Cys  Ile Lys Asn Leu Phe  Ser Pro Ile Met Ser  Glu Asn His 
    2075                 2080                 2085             


Gly His  Met Pro Leu Gln Pro  Asn Ala Ser Leu Asn  Glu Glu Glu 
    2090                 2095                 2100             


Gly Thr  Gln Gly His Pro Asp  Gly Thr Pro Pro Lys  Leu Asp Thr 
    2105                 2110                 2115             


Ala Asn  Gly Thr Pro Lys Val  Tyr Lys Ser Ala Asp  Ser Ser Thr 
    2120                 2125                 2130             


Val Lys  Lys Gly Pro Pro Val  Ala Pro Lys Pro Ala  Trp Phe Arg 
    2135                 2140                 2145             


Gln Ser  Leu Lys Gly Leu Arg  Asn Arg Ala Ser Asp  Pro Arg Gly 
    2150                 2155                 2160             


Leu Pro  Asp Pro Ala Leu Ser  Thr Gln Pro Ala Pro  Ala Ser Arg 
    2165                 2170                 2175             


Glu His  Leu Gly Ser His Ile  Arg Ala Ser Ser Ser  Ser Ser Ser 
    2180                 2185                 2190             


Ile Arg  Gln Arg Ile Ser Ser  Phe Glu Thr Phe Gly  Ser Ser Gln 
    2195                 2200                 2205             


Leu Pro  Asp Lys Gly Ala Gln  Arg Leu Ser Leu Gln  Pro Ser Ser 
    2210                 2215                 2220             


Gly Glu  Ala Ala Lys Pro Leu  Gly Lys His Glu Glu  Gly Arg Phe 
    2225                 2230                 2235             


Ser Gly  Leu Leu Gly Arg Gly  Ala Ala Pro Thr Leu  Val Pro Gln 
    2240                 2245                 2250             


Gln Pro  Glu Gln Val Leu Ser  Ser Gly Ser Pro Ala  Ala Ser Glu 
    2255                 2260                 2265             


Ala Arg  Asp Pro Gly Val Ser  Glu Ser Pro Pro Pro  Gly Arg Gln 
    2270                 2275                 2280             


Pro Asn  Gln Lys Thr Leu Pro  Pro Gly Pro Asp Pro  Leu Leu Arg 
    2285                 2290                 2295             


Leu Leu  Ser Thr Gln Ala Glu  Glu Ser Gln Gly Pro  Val Leu Lys 
    2300                 2305                 2310             


Met Pro  Ser Gln Arg Ala Arg  Ser Phe Pro Leu Thr  Arg Ser Gln 
    2315                 2320                 2325             


Ser Cys  Glu Thr Lys Leu Leu  Asp Glu Lys Thr Ser  Lys Leu Tyr 
    2330                 2335                 2340             


Ser Ile  Ser Ser Gln Val Ser  Ser Ala Val Met Lys  Ser Leu Leu 
    2345                 2350                 2355             


Cys Leu  Pro Ser Ser Ile Ser  Cys Ala Gln Thr Pro  Cys Ile Pro 
    2360                 2365                 2370             


Lys Glu  Gly Ala Ser Pro Thr  Ser Ser Ser Asn Glu  Asp Ser Ala 
    2375                 2380                 2385             


Ala Asn  Gly Ser Ala Glu Thr  Ser Ala Leu Asp Thr  Gly Phe Ser 
    2390                 2395                 2400             


Leu Asn  Leu Ser Glu Leu Arg  Glu Tyr Thr Glu Gly  Leu Thr Glu 
    2405                 2410                 2415             


Ala Lys  Glu Asp Asp Asp Gly  Asp His Ser Ser Leu  Gln Ser Gly 
    2420                 2425                 2430             


Gln Ser  Val Ile Ser Leu Leu  Ser Ser Glu Glu Leu  Lys Lys Leu 
    2435                 2440                 2445             


Ile Glu  Glu Val Lys Val Leu  Asp Glu Ala Thr Leu  Lys Gln Leu 
    2450                 2455                 2460             


Asp Gly  Ile His Val Thr Ile  Leu His Lys Glu Glu  Gly Ala Gly 
    2465                 2470                 2475             


Leu Gly  Phe Ser Leu Ala Gly  Gly Ala Asp Leu Glu  Asn Lys Val 
    2480                 2485                 2490             


Ile Thr  Val His Arg Val Phe  Pro Asn Gly Leu Ala  Ser Gln Glu 
    2495                 2500                 2505             


Gly Thr  Ile Gln Lys Gly Asn  Glu Val Leu Ser Ile  Asn Gly Lys 
    2510                 2515                 2520             


Ser Leu  Lys Gly Thr Thr His  His Asp Ala Leu Ala  Ile Leu Arg 
    2525                 2530                 2535             


Gln Ala  Arg Glu Pro Arg Gln  Ala Val Ile Val Thr  Arg Lys Leu 
    2540                 2545                 2550             


Thr Pro  Glu Ala Met Pro Asp  Leu Asn Ser Ser Thr  Asp Ser Ala 
    2555                 2560                 2565             


Ala Ser  Ala Ser Ala Ala Ser  Asp Val Ser Val Glu  Ser Thr Ala 
    2570                 2575                 2580             


Glu Ala  Thr Val Cys Thr Val  Thr Leu Glu Lys Met  Ser Ala Gly 
    2585                 2590                 2595             


Leu Gly  Phe Ser Leu Glu Gly  Gly Lys Gly Ser Leu  His Gly Asp 
    2600                 2605                 2610             


Lys Pro  Leu Thr Ile Asn Arg  Ile Phe Lys Gly Ala  Ala Ser Glu 
    2615                 2620                 2625             


Gln Ser  Glu Thr Val Gln Pro  Gly Asp Glu Ile Leu  Gln Leu Gly 
    2630                 2635                 2640             


Gly Thr  Ala Met Gln Gly Leu  Thr Arg Phe Glu Ala  Trp Asn Ile 
    2645                 2650                 2655             


Ile Lys  Ala Leu Pro Asp Gly  Pro Val Thr Ile Val  Ile Arg Arg 
    2660                 2665                 2670             


Lys Ser  Leu Gln Ser Lys Glu  Thr Thr Ala Ala Gly  Asp Ser Ala 
    2675                 2680                 2685             


Gly Ser  Gly Phe Asn Asn Phe  Thr Val Ser Phe Trp  Leu Arg Val 
    2690                 2695                 2700             


Pro Lys  Val Ser Ala Ser His  Leu Glu Ser Gly Gly  Ser Met Glu 
    2705                 2710                 2715             


Ser His  Ser Arg Ala Gly Lys  Ser Arg Lys Ser Ala  Lys Phe Arg 
    2720                 2725                 2730             


Ser Ile  Ser Arg Ser Leu Met  Leu Cys Asn Ala Lys  Thr Ser Asp 
    2735                 2740                 2745             


Asp Gly  Ser Ser Pro Asp Glu  Lys Tyr Pro Asp Pro  Phe Glu Ile 
    2750                 2755                 2760             


Ser Leu  Ala Gln Gly Lys Glu  Gly Ile Phe His Ser  Ser Val Gln 
    2765                 2770                 2775             


Leu Ala  Asp Thr Ser Glu Ala  Gly Pro Ser Ser Val  Pro Asp Leu 
    2780                 2785                 2790             


Ala Leu  Ala Ser Glu Ala Ala  Gln Leu Gln Ala Ala  Gly Asn Asp 
    2795                 2800                 2805             


Arg Gly  Lys Thr Cys Arg Arg  Ile Phe Phe Met Lys  Glu Ser Ser 
    2810                 2815                 2820             


Thr Ala  Ser Ser Arg Glu Lys  Pro Gly Lys Leu Glu  Ala Gln Ser 
    2825                 2830                 2835             


Ser Asn  Phe Leu Phe Pro Lys  Ala Cys His Gln Arg  Ala Arg Ser 
    2840                 2845                 2850             


Asn Ser  Thr Ser Val Asn Pro  Tyr Cys Thr Arg Glu  Ile Asp Phe 
    2855                 2860                 2865             


Pro Met  Thr Lys Lys Ser Ala  Ala Pro Thr Asp Arg  Gln Pro Tyr 
    2870                 2875                 2880             


Ser Leu  Cys Ser Asn Arg Lys  Ser Leu Ser Gln Gln  Leu Asp Cys 
    2885                 2890                 2895             


Pro Ala  Gly Lys Ala Ala Gly  Thr Ser Arg Pro Thr  Arg Ser Leu 
    2900                 2905                 2910             


Ser Thr  Ala Gln Leu Val Gln  Pro Ser Gly Gly Leu  Gln Ala Ser 
    2915                 2920                 2925             


Val Ile  Ser Asn Ile Val Leu  Met Lys Gly Gln Ala  Lys Gly Leu 
    2930                 2935                 2940             


Gly Phe  Ser Ile Val Gly Gly  Lys Asp Ser Ile Tyr  Gly Pro Ile 
    2945                 2950                 2955             


Gly Ile  Tyr Val Lys Thr Ile  Phe Ala Gly Gly Ala  Ala Ala Ala 
    2960                 2965                 2970             


Asp Gly  Arg Leu Gln Glu Gly  Asp Glu Ile Leu Glu  Leu Asn Gly 
    2975                 2980                 2985             


Glu Ser  Met Ala Gly Leu Thr  His Gln Asp Ala Leu  Gln Lys Phe 
    2990                 2995                 3000             


Lys Gln  Ala Lys Lys Gly Leu  Leu Thr Leu Thr Val  Arg Thr Arg 
    3005                 3010                 3015             


Leu Thr  Ala Pro Pro Ser Leu  Cys Ser His Leu Ser  Pro Pro Leu 
    3020                 3025                 3030             


Cys Arg  Ser Leu Ser Ser Ser  Thr Cys Ile Thr Lys  Asp Ser Ser 
    3035                 3040                 3045             


Ser Phe  Ala Leu Glu Ser Pro  Ser Ala Pro Ile Ser  Thr Ala Lys 
    3050                 3055                 3060             


Pro Asn  Tyr Arg Ile Met Val  Glu Val Ser Leu Gln  Lys Glu Ala 
    3065                 3070                 3075             


Gly Val  Gly Leu Gly Ile Gly  Leu Cys Ser Val Pro  Tyr Phe Gln 
    3080                 3085                 3090             


Cys Ile  Ser Gly Ile Phe Val  His Thr Leu Ser Pro  Gly Ser Val 
    3095                 3100                 3105             


Ala His  Leu Asp Gly Arg Leu  Arg Cys Gly Asp Glu  Ile Val Glu 
    3110                 3115                 3120             


Ile Ser  Asp Ser Pro Val His  Cys Leu Thr Leu Asn  Glu Val Tyr 
    3125                 3130                 3135             


Thr Ile  Leu Ser His Cys Asp  Pro Gly Pro Val Pro  Ile Ile Val 
    3140                 3145                 3150             


Ser Arg  His Pro Asp Pro Gln  Val Ser Glu Gln Gln  Leu Lys Glu 
    3155                 3160                 3165             


Ala Val  Ala Gln Ala Val Glu  Asn Thr Lys Phe Gly  Lys Glu Arg 
    3170                 3175                 3180             


His Gln  Trp Ser Leu Glu Gly  Val Lys Arg Leu Glu  Ser Ser Trp 
    3185                 3190                 3195             


His Gly  Arg Pro Thr Leu Glu  Lys Glu Arg Glu Lys  Asn Ser Ala 
    3200                 3205                 3210             


Pro Pro  His Arg Arg Ala Gln  Lys Val Met Ile Arg  Ser Ser Ser 
    3215                 3220                 3225             


Asp Ser  Ser Tyr Met Ser Gly  Ser Pro Gly Gly Ser  Pro Gly Ser 
    3230                 3235                 3240             


Gly Ser  Ala Glu Lys Pro Ser  Ser Asp Val Asp Ile  Ser Thr His 
    3245                 3250                 3255             


Ser Pro  Ser Leu Pro Leu Ala  Arg Glu Pro Val Val  Leu Ser Ile 
    3260                 3265                 3270             


Ala Ser  Ser Arg Leu Pro Gln  Glu Ser Pro Pro Leu  Pro Glu Ser 
    3275                 3280                 3285             


Arg Asp  Ser His Pro Pro Leu  Arg Leu Lys Lys Ser  Phe Glu Ile 
    3290                 3295                 3300             


Leu Val  Arg Lys Pro Met Ser  Ser Lys Pro Lys Pro  Pro Pro Arg 
    3305                 3310                 3315             


Lys Tyr  Phe Lys Ser Asp Ser  Asp Pro Gln Lys Ser  Leu Glu Glu 
    3320                 3325                 3330             


Arg Glu  Asn Ser Ser Cys Ser  Ser Gly His Thr Pro  Pro Thr Cys 
    3335                 3340                 3345             


Gly Gln  Glu Ala Arg Glu Leu  Leu Pro Leu Leu Leu  Pro Gln Glu 
    3350                 3355                 3360             


Asp Thr  Ala Gly Arg Ser Pro  Ser Ala Ser Ala Gly  Cys Pro Gly 
    3365                 3370                 3375             


Pro Gly  Ile Gly Pro Gln Thr  Lys Ser Ser Thr Glu  Gly Glu Pro 
    3380                 3385                 3390             


Gly Trp  Arg Arg Ala Ser Pro  Val Thr Gln Thr Ser  Pro Ile Lys 
    3395                 3400                 3405             


His Pro  Leu Leu Lys Arg Gln  Ala Arg Met Asp Tyr  Ser Phe Asp 
    3410                 3415                 3420             


Thr Thr  Ala Glu Asp Pro Trp  Val Arg Ile Ser Asp  Cys Ile Lys 
    3425                 3430                 3435             


Asn Leu  Phe Ser Pro Ile Met  Ser Glu Asn His Gly  His Met Pro 
    3440                 3445                 3450             


Leu Gln  Pro Asn Ala Ser Leu  Asn Glu Glu Glu Gly  Thr Gln Gly 
    3455                 3460                 3465             


His Pro  Asp Gly Thr Pro Pro  Lys Leu Asp Thr Ala  Asn Gly Thr 
    3470                 3475                 3480             


Pro Lys  Val Tyr Lys Ser Ala  Asp Ser Ser Thr Val  Lys Lys Gly 
    3485                 3490                 3495             


Pro Pro  Val Ala Pro Lys Pro  Ala Trp Phe Arg Gln  Ser Leu Lys 
    3500                 3505                 3510             


Gly Leu  Arg Asn Arg Ala Ser  Asp Pro Arg Gly Leu  Pro Asp Pro 
    3515                 3520                 3525             


Ala Leu  Ser Thr Gln Pro Ala  Pro Ala Ser Arg Glu  His Leu Gly 
    3530                 3535                 3540             


Ser His  Ile Arg Ala Ser Ser  Ser Ser Ser Ser Ile  Arg Gln Arg 
    3545                 3550                 3555             


Ile Ser  Ser Phe Glu Thr Phe  Gly Ser Ser Gln Leu  Pro Asp Lys 
    3560                 3565                 3570             


Gly Ala  Gln Arg Leu Ser Leu  Gln Pro Ser Ser Gly  Glu Ala Ala 
    3575                 3580                 3585             


Lys Pro  Leu Gly Lys His Glu  Glu Gly Arg Phe Ser  Gly Leu Leu 
    3590                 3595                 3600             


Gly Arg  Gly Ala Ala Pro Thr  Leu Val Pro Gln Gln  Pro Glu Gln 
    3605                 3610                 3615             


Val Leu  Ser Ser Gly Ser Pro  Ala Ala Ser Glu Ala  Arg Asp Pro 
    3620                 3625                 3630             


Gly Val  Ser Glu Ser Pro Pro  Pro Gly Arg Gln Pro  Asn Gln Lys 
    3635                 3640                 3645             


Thr Leu  Pro Pro Gly Pro Asp  Pro Leu Leu Arg Leu  Leu Ser Thr 
    3650                 3655                 3660             


Gln Ala  Glu Glu Ser Gln Gly  Pro Val Leu Lys Met  Pro Ser Gln 
    3665                 3670                 3675             


Arg Ala  Arg Ser Phe Pro Leu  Thr Arg Ser Gln Ser  Cys Glu Thr 
    3680                 3685                 3690             


Lys Leu  Leu Asp Glu Lys Thr  Ser Lys Leu Tyr Ser  Ile Ser Ser 
    3695                 3700                 3705             


Gln Val  Ser Ser Ala Val Met  Lys Ser Leu Leu Cys  Leu Pro Ser 
    3710                 3715                 3720             


Ser Ile  Ser Cys Ala Gln Thr  Pro Cys Ile Pro Lys  Glu Gly Ala 
    3725                 3730                 3735             


Ser Pro  Thr Ser Ser Ser Asn  Glu Asp Ser Ala Ala  Asn Gly Ser 
    3740                 3745                 3750             


Ala Glu  Thr Ser Ala Leu Asp  Thr Gly Phe Ser Leu  Asn Leu Ser 
    3755                 3760                 3765             


Glu Leu  Arg Glu Tyr Thr Glu  Gly Leu Thr Glu Ala  Lys Glu Asp 
    3770                 3775                 3780             


Asp Asp  Gly Asp His Ser Ser  Leu Gln Ser Gly Gln  Ser Val Ile 
    3785                 3790                 3795             


Ser Leu  Leu Ser Ser Glu Glu  Leu Lys Lys Leu Ile  Glu Glu Val 
    3800                 3805                 3810             


Lys Val  Leu Asp Glu Ala Thr  Leu Lys Gln Leu Asp  Gly Ile His 
    3815                 3820                 3825             


Val Thr  Ile Leu His Lys Glu  Glu Gly Ala Gly Leu  Gly Phe Ser 
    3830                 3835                 3840             


Leu Ala  Gly Gly Ala Asp Leu  Glu Asn Lys Val Ile  Thr Val His 
    3845                 3850                 3855             


Arg Val  Phe Pro Asn Gly Leu  Ala Ser Gln Glu Gly  Thr Ile Gln 
    3860                 3865                 3870             


Lys Gly  Asn Glu Val Leu Ser  Ile Asn Gly Lys Ser  Leu Lys Gly 
    3875                 3880                 3885             


Thr Thr  His His Asp Ala Leu  Ala Ile Leu Arg Gln  Ala Arg Glu 
    3890                 3895                 3900             


Pro Arg  Gln Ala Val Ile Val  Thr Arg Lys Leu Thr  Pro Glu Ala 
    3905                 3910                 3915             


Met Pro  Asp Leu Asn Ser Ser  Thr Asp Ser Ala Ala  Ser Ala Ser 
    3920                 3925                 3930             


Ala Ala  Ser Asp Val Ser Val  Glu Ser Thr Ala Glu  Ala Thr Val 
    3935                 3940                 3945             


Cys Thr  Val Thr Leu Glu Lys  Met Ser Ala Gly Leu  Gly Phe Ser 
    3950                 3955                 3960             


Leu Glu  Gly Gly Lys Gly Ser  Leu His Gly Asp Lys  Pro Leu Thr 
    3965                 3970                 3975             


Ile Asn  Arg Ile Phe Lys Gly  Ala Ala Ser Glu Gln  Ser Glu Thr 
    3980                 3985                 3990             


Val Gln  Pro Gly Asp Glu Ile  Leu Gln Leu Gly Gly  Thr Ala Met 
    3995                 4000                 4005             


Gln Gly  Leu Thr Arg Phe Glu  Ala Trp Asn Ile Ile  Lys Ala Leu 
    4010                 4015                 4020             


Pro Asp  Gly Pro Val Thr Ile  Val Ile Arg Arg Lys  Ser Leu Gln 
    4025                 4030                 4035             


Ser Lys  Glu Thr Thr Ala Ala  Gly Asp Ser Ala Gly  Ser Gly Phe 
    4040                 4045                 4050             


Asn Asn  Phe Thr Val Ser Phe  Trp Leu Arg Val Pro  Lys Val Ser 
    4055                 4060                 4065             


Ala Ser  His Leu Glu Gly Ser  Gly Gly Gln Tyr Ile  Lys Ala Asn 
    4070                 4075                 4080             


Ser Lys  Phe Ile Gly Ile Thr  Glu Leu His His His  His His His 
    4085                 4090                 4095             


<210>  263
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-16 (1212-1332) 
       polyprotein.

<400>  263

Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 
1               5                   10                  15      


Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 
            20                  25                  30          


Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 
        35                  40                  45              


Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 
    50                  55                  60                  


Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 
                85                  90                  95      


Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 
            100                 105                 110         


Lys Glu Thr Thr Ala Ala Gly Asp Ser Gly Ser Gly Gly Gln Tyr Ile 
        115                 120                 125             


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly 
    130                 135                 140                 


Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 
145                 150                 155                 160 


Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 
                165                 170                 175     


Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 
            180                 185                 190         


Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 
        195                 200                 205             


Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 
    210                 215                 220                 


Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 
225                 230                 235                 240 


Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 
                245                 250                 255     


Lys Glu Thr Thr Ala Ala Gly Asp Ser Ala Gly Ser Gly Phe Asn Asn 
            260                 265                 270         


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
        275                 280                 285             


Leu Glu Ser Gly Gly Ser Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp 
    290                 295                 300                 


Val Ser Val Glu Ser Thr Ala Glu Ala Thr Val Cys Thr Val Thr Leu 
305                 310                 315                 320 


Glu Lys Met Ser Ala Gly Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly 
                325                 330                 335     


Ser Leu His Gly Asp Lys Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly 
            340                 345                 350         


Ala Ala Ser Glu Gln Ser Glu Thr Val Gln Pro Gly Asp Glu Ile Leu 
        355                 360                 365             


Gln Leu Gly Gly Thr Ala Met Gln Gly Leu Thr Arg Phe Glu Ala Trp 
    370                 375                 380                 


Asn Ile Ile Lys Ala Leu Pro Asp Gly Pro Val Thr Ile Val Ile Arg 
385                 390                 395                 400 


Arg Lys Ser Leu Gln Ser Lys Glu Thr Thr Ala Ala Gly Asp Ser Ala 
                405                 410                 415     


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
            420                 425                 430         


Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys 
        435                 440                 445             


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His 
    450                 455                 460                 


His 
465 


<210>  264
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-17A polyprotein.

<400>  264

Phe Pro Gln Asn Pro Gly Cys Arg Asn Thr Glu Asp Lys Asn Phe Pro 
1               5                   10                  15      


Gln His Val Lys Val Asn Leu Asn Ile Leu Asn Arg Asn Thr Asn Ser 
            20                  25                  30          


Arg Arg Pro Ser Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu 
        35                  40                  45              


His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala 
    50                  55                  60                  


Lys Cys Arg His Leu Gly Cys Val Asn Asn Glu Gly Asn Ile Asn Tyr 
65                  70                  75                  80  


His Met Asn Ser Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg 
                85                  90                  95      


Glu Ser Gln His Cys Pro His Ser Phe Arg Leu Glu Lys Met Leu Val 
            100                 105                 110         


Ala Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg His Val Ala Gly 
        115                 120                 125             


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
    130                 135                 140                 


Glu Leu Ala Gly Ser Gly Phe Pro Gln Asn Pro Gly Cys Arg Asn Thr 
145                 150                 155                 160 


Glu Asp Lys Asn Phe Pro Gln His Val Lys Val Asn Leu Asn Ile Leu 
                165                 170                 175     


Asn Arg Asn Thr Asn Ser Arg Arg Pro Ser Asp Tyr Tyr Asn Arg Ser 
            180                 185                 190         


Thr Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro 
        195                 200                 205             


Ser Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Val Asn Asn 
    210                 215                 220                 


Glu Gly Asn Ile Asn Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu 
225                 230                 235                 240 


Ile Leu Val Leu Arg Arg Glu Ser Gln His Cys Pro His Ser Phe Arg 
                245                 250                 255     


Leu Glu Lys Met Leu Val Ala Val Gly Cys Thr Cys Val Thr Pro Ile 
            260                 265                 270         


Val Arg His Val Ala Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
        275                 280                 285             


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
    290                 295                 300                 


Gly Ser Phe Pro Gln Asn Pro Gly Cys Arg Asn Thr Glu Asp Lys Asn 
305                 310                 315                 320 


Phe Pro Gln His Val Lys Val Asn Leu Asn Ile Leu Asn Arg Asn Thr 
                325                 330                 335     


Asn Ser Arg Arg Pro Ser Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp 
            340                 345                 350         


Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp 
        355                 360                 365             


Glu Ala Lys Cys Arg His Leu Gly Cys Val Asn Asn Glu Gly Asn Ile 
    370                 375                 380                 


Asn Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile Leu Val Leu 
385                 390                 395                 400 


Arg Arg Glu Ser Gln His Cys Pro His Ser Phe Arg Leu Glu Lys Met 
                405                 410                 415     


Leu Val Ala Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg His Val 
            420                 425                 430         


Ala Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
        435                 440                 445             


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
    450                 455                 460                 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
465                 470                 475                 480 


His His His 
            


<210>  265
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-17A polyprotein.

<400>  265

Phe Pro Gln Asn Pro Gly Cys Pro Thr Thr Glu Asp Lys Asn Phe Pro 
1               5                   10                  15      


Gln His Val Lys Val Asn Val Asn Ile Leu Asn Gly Asn Lys Ser Ser 
            20                  25                  30          


Arg Arg Pro Leu Asp Tyr Tyr Arg Arg Ser Thr Ser Pro Trp Ser Leu 
        35                  40                  45              


His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala 
    50                  55                  60                  


Lys Cys Leu His Trp Gly Cys Val Asn Thr Glu Gly Lys Glu Asp His 
65                  70                  75                  80  


His Met Asn Ser Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg 
                85                  90                  95      


Glu Ser Arg His Cys Pro His Ser Phe Arg Leu Glu Lys Met Leu Val 
            100                 105                 110         


Thr Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg His Val Val Gly 
        115                 120                 125             


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
    130                 135                 140                 


Glu Leu Ala Gly Ser Gly Phe Pro Gln Asn Pro Gly Cys Pro Thr Thr 
145                 150                 155                 160 


Glu Asp Lys Asn Phe Pro Gln His Val Lys Val Asn Val Asn Ile Leu 
                165                 170                 175     


Asn Gly Asn Lys Ser Ser Arg Arg Pro Leu Asp Tyr Tyr Arg Arg Ser 
            180                 185                 190         


Thr Ser Pro Trp Ser Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro 
        195                 200                 205             


Ser Val Ile Trp Glu Ala Lys Cys Leu His Trp Gly Cys Val Asn Thr 
    210                 215                 220                 


Glu Gly Lys Glu Asp His His Met Asn Ser Val Pro Ile Gln Gln Glu 
225                 230                 235                 240 


Ile Leu Val Leu Arg Arg Glu Ser Arg His Cys Pro His Ser Phe Arg 
                245                 250                 255     


Leu Glu Lys Met Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Ile 
            260                 265                 270         


Val Arg His Val Val Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
        275                 280                 285             


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
    290                 295                 300                 


Gly Ser Phe Pro Gln Asn Pro Gly Cys Pro Thr Thr Glu Asp Lys Asn 
305                 310                 315                 320 


Phe Pro Gln His Val Lys Val Asn Val Asn Ile Leu Asn Gly Asn Lys 
                325                 330                 335     


Ser Ser Arg Arg Pro Leu Asp Tyr Tyr Arg Arg Ser Thr Ser Pro Trp 
            340                 345                 350         


Ser Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp 
        355                 360                 365             


Glu Ala Lys Cys Leu His Trp Gly Cys Val Asn Thr Glu Gly Lys Glu 
    370                 375                 380                 


Asp His His Met Asn Ser Val Pro Ile Gln Gln Glu Ile Leu Val Leu 
385                 390                 395                 400 


Arg Arg Glu Ser Arg His Cys Pro His Ser Phe Arg Leu Glu Lys Met 
                405                 410                 415     


Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg His Val 
            420                 425                 430         


Val Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
        435                 440                 445             


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
    450                 455                 460                 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
465                 470                 475                 480 


His His His 
            


<210>  266
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-17B polyprotein.

<400>  266

Arg Asn Pro Lys Gly Lys Arg Lys Gly Pro Gly Arg Pro Gly Thr Leu 
1               5                   10                  15      


Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Gln Ala Lys 
            20                  25                  30          


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Leu Ser Glu Met Val 
        35                  40                  45              


Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala Arg Arg Lys Cys Glu Val 
    50                  55                  60                  


Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg Ser Leu Ser Pro Trp Gly 
65                  70                  75                  80  


Tyr Ser Ile Asn His Asp Pro Ser Arg Val Pro Ala Asp Leu Pro Glu 
                85                  90                  95      


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
            100                 105                 110         


Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
        115                 120                 125             


Arg Arg Leu Cys Pro Leu Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
    130                 135                 140                 


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe Gly Ser 
145                 150                 155                 160 


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
                165                 170                 175     


Leu Ala Gly Ser Gly Arg Asn Pro Lys Gly Lys Arg Lys Gly Pro Gly 
            180                 185                 190         


Arg Pro Gly Thr Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu 
        195                 200                 205             


Val Ser Gln Ala Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn 
    210                 215                 220                 


Leu Ser Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala Arg 
225                 230                 235                 240 


Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg Ser 
                245                 250                 255     


Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Val Pro 
            260                 265                 270         


Ala Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro 
        275                 280                 285             


Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe Ser 
    290                 295                 300                 


Gln Val Pro Val Arg Arg Arg Leu Cys Pro Leu Pro Pro Arg Thr Gly 
305                 310                 315                 320 


Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr 
                325                 330                 335     


Cys Ile Phe Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
            340                 345                 350         


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
        355                 360                 365             


Arg Asn Pro Lys Gly Lys Arg Lys Gly Pro Gly Arg Pro Gly Thr Leu 
    370                 375                 380                 


Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Gln Ala Lys 
385                 390                 395                 400 


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Leu Ser Glu Met Val 
                405                 410                 415     


Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala Arg Arg Lys Cys Glu Val 
            420                 425                 430         


Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg Ser Leu Ser Pro Trp Gly 
        435                 440                 445             


Tyr Ser Ile Asn His Asp Pro Ser Arg Val Pro Ala Asp Leu Pro Glu 
    450                 455                 460                 


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
465                 470                 475                 480 


Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
                485                 490                 495     


Arg Arg Leu Cys Pro Leu Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
            500                 505                 510         


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe Ala Gly 
        515                 520                 525             


Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
    530                 535                 540                 


Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
545                 550                 555                 560 


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
                565                 570                 575     


<210>  267
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-17B polyprotein.

<400>  267

Arg Asn Pro Lys Gly Lys Arg Lys Gly Pro Gly Arg Pro Gly Thr Leu 
1               5                   10                  15      


Ala Ser Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Gln Ala Lys 
            20                  25                  30          


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Leu Gly Glu Met Val 
        35                  40                  45              


Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala Arg Arg Lys Cys Glu Val 
    50                  55                  60                  


Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg Ser Leu Ser Pro Trp Gly 
65                  70                  75                  80  


Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Ala Asp Leu Pro Glu 
                85                  90                  95      


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
            100                 105                 110         


Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
        115                 120                 125             


Arg Arg Leu Cys Pro Leu Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
    130                 135                 140                 


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe Gly Ser 
145                 150                 155                 160 


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
                165                 170                 175     


Leu Ala Gly Ser Gly Arg Asn Pro Lys Gly Lys Arg Lys Gly Pro Gly 
            180                 185                 190         


Arg Pro Gly Thr Leu Ala Ser Gly Pro His Gln Val Pro Leu Asp Leu 
        195                 200                 205             


Val Ser Gln Ala Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn 
    210                 215                 220                 


Leu Gly Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala Arg 
225                 230                 235                 240 


Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg Ser 
                245                 250                 255     


Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro 
            260                 265                 270         


Ala Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro 
        275                 280                 285             


Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe Ser 
    290                 295                 300                 


Gln Val Pro Val Arg Arg Arg Leu Cys Pro Leu Pro Pro Arg Thr Gly 
305                 310                 315                 320 


Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr 
                325                 330                 335     


Cys Ile Phe Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
            340                 345                 350         


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
        355                 360                 365             


Arg Asn Pro Lys Gly Lys Arg Lys Gly Pro Gly Arg Pro Gly Thr Leu 
    370                 375                 380                 


Ala Ser Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Gln Ala Lys 
385                 390                 395                 400 


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Leu Gly Glu Met Val 
                405                 410                 415     


Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala Arg Arg Lys Cys Glu Val 
            420                 425                 430         


Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg Ser Leu Ser Pro Trp Gly 
        435                 440                 445             


Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Ala Asp Leu Pro Glu 
    450                 455                 460                 


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
465                 470                 475                 480 


Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
                485                 490                 495     


Arg Arg Leu Cys Pro Leu Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
            500                 505                 510         


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe Ala Gly 
        515                 520                 525             


Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
    530                 535                 540                 


Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
545                 550                 555                 560 


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
                565                 570                 575     


<210>  268
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-17B polyprotein.

<400>  268

Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln Gly Arg Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Arg 
            20                  25                  30          


Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Ile Glu Glu 
        35                  40                  45              


Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala Gln Arg Lys Cys 
    50                  55                  60                  


Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg Ser Leu Ser Pro 
65                  70                  75                  80  


Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu 
                85                  90                  95      


Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met 
            100                 105                 110         


Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro 
        115                 120                 125             


Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr Gly Pro Cys Arg 
    130                 135                 140                 


Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe 
145                 150                 155                 160 


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
                165                 170                 175     


Thr Glu Leu Ala Gly Ser Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg 
            180                 185                 190         


Lys Gly Gln Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val 
        195                 200                 205             


Pro Leu Asp Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu 
    210                 215                 220                 


Tyr Glu Arg Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser 
225                 230                 235                 240 


Glu Leu Ala Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser 
                245                 250                 255     


Asn Lys Arg Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro 
            260                 265                 270         


Ser Arg Ile Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly 
        275                 280                 285             


Cys Val Asn Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val 
    290                 295                 300                 


Pro Val Phe Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro 
305                 310                 315                 320 


Pro Arg Thr Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala 
                325                 330                 335     


Val Gly Cys Thr Cys Ile Phe Ala Gly Ser Gly Phe Asn Asn Phe Thr 
            340                 345                 350         


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
        355                 360                 365             


Ser Gly Gly Ser Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
    370                 375                 380                 


Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
385                 390                 395                 400 


Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
                405                 410                 415     


Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
            420                 425                 430         


Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
        435                 440                 445             


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
    450                 455                 460                 


Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
465                 470                 475                 480 


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
                485                 490                 495     


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
            500                 505                 510         


Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
        515                 520                 525             


Thr Cys Ile Phe Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
    530                 535                 540                 


Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly 
545                 550                 555                 560 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                565                 570                 575     


His His His His His His 
            580         


<210>  269
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-17C polyprotein.

<400>  269

Arg His Gly Pro Gln Leu Trp Arg Gly Leu His Thr His Gly Thr Pro 
1               5                   10                  15      


Arg Cys Tyr Ser Ala Glu Glu Leu Pro Arg Gly Gln Ala Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Ala Ala Lys Trp Glu Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Gly Gly Arg Gly Arg Glu Gln Asp Gly Pro 
    50                  55                  60                  


Pro Ala Gly Ala Gln Cys Pro Val Leu Gln Pro Glu Glu Val Leu Glu 
65                  70                  75                  80  


Ala Asp Ile His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Ser Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Ile Ser Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Asn Ser Val Pro Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Arg Pro 
    130                 135                 140                 


Cys Ser Arg Asp Thr Thr Gly Leu Pro Thr Pro Gly Ala Phe Ser Phe 
145                 150                 155                 160 


His Ala Glu Phe Ile Arg Val Pro Ile Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Thr Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
            180                 185                 190         


Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Arg His Gly Pro Gln Leu 
        195                 200                 205             


Trp Arg Gly Leu His Thr His Gly Thr Pro Arg Cys Tyr Ser Ala Glu 
    210                 215                 220                 


Glu Leu Pro Arg Gly Gln Ala Pro Pro His Leu Leu Ala Arg Ala Ala 
225                 230                 235                 240 


Lys Trp Glu Gln Ala Leu Pro Val Ala Leu Val Ser Ser Leu Glu Ala 
                245                 250                 255     


Gly Gly Arg Gly Arg Glu Gln Asp Gly Pro Pro Ala Gly Ala Gln Cys 
            260                 265                 270         


Pro Val Leu Gln Pro Glu Glu Val Leu Glu Ala Asp Ile His Gln Arg 
        275                 280                 285             


Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp Thr Asp Glu Ser Arg Tyr 
    290                 295                 300                 


Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu Cys Arg Gly Cys Ile Ser 
305                 310                 315                 320 


Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu Asn Ser Val Pro Leu Leu 
                325                 330                 335     


Gln Ser Leu Leu Val Leu Arg Arg Arg Pro Cys Ser Arg Asp Thr Thr 
            340                 345                 350         


Gly Leu Pro Thr Pro Gly Ala Phe Ser Phe His Ala Glu Phe Ile Arg 
        355                 360                 365             


Val Pro Ile Gly Cys Thr Cys Val Leu Pro Arg Ser Thr Ala Gly Ser 
    370                 375                 380                 


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
385                 390                 395                 400 


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Arg His Gly Pro Gln Leu 
                405                 410                 415     


Trp Arg Gly Leu His Thr His Gly Thr Pro Arg Cys Tyr Ser Ala Glu 
            420                 425                 430         


Glu Leu Pro Arg Gly Gln Ala Pro Pro His Leu Leu Ala Arg Ala Ala 
        435                 440                 445             


Lys Trp Glu Gln Ala Leu Pro Val Ala Leu Val Ser Ser Leu Glu Ala 
    450                 455                 460                 


Gly Gly Arg Gly Arg Glu Gln Asp Gly Pro Pro Ala Gly Ala Gln Cys 
465                 470                 475                 480 


Pro Val Leu Gln Pro Glu Glu Val Leu Glu Ala Asp Ile His Gln Arg 
                485                 490                 495     


Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp Thr Asp Glu Ser Arg Tyr 
            500                 505                 510         


Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu Cys Arg Gly Cys Ile Ser 
        515                 520                 525             


Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu Asn Ser Val Pro Leu Leu 
    530                 535                 540                 


Gln Ser Leu Leu Val Leu Arg Arg Arg Pro Cys Ser Arg Asp Thr Thr 
545                 550                 555                 560 


Gly Leu Pro Thr Pro Gly Ala Phe Ser Phe His Ala Glu Phe Ile Arg 
                565                 570                 575     


Val Pro Ile Gly Cys Thr Cys Val Leu Pro Arg Ser Thr Ala Gly Ser 
            580                 585                 590         


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
        595                 600                 605             


Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
    610                 615                 620                 


Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
625                 630                 635                 


<210>  270
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-17C polyprotein.

<400>  270

Arg His Gly Pro Gln Leu Trp Gly Gly Pro His Ala His Gly Thr Pro 
1               5                   10                  15      


Arg Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Pro Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Ala Ala Lys Trp Glu Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Gly Gly Arg Arg Arg Arg His Asp Gly Pro 
    50                  55                  60                  


Pro Ala Gly Thr Gln Cys Pro Val Leu Arg Pro Glu Asp Val Leu Glu 
65                  70                  75                  80  


Ala Gly Ile His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Ser Arg Tyr Pro Gln Lys Leu Ala Phe Ala Gln Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Val Ser Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Asn Ser Val Pro Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Gln Pro 
    130                 135                 140                 


Cys Ser Arg Glu Ala Thr Gly Leu Pro Thr Pro Gly Ala Phe Ser Phe 
145                 150                 155                 160 


His Ala Glu Phe Ile Arg Val Pro Val Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
            180                 185                 190         


Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Arg His Gly Pro Gln 
        195                 200                 205             


Leu Trp Gly Gly Pro His Ala His Gly Thr Pro Arg Cys Tyr Ser Ala 
    210                 215                 220                 


Glu Glu Leu Pro Leu Gly Gln Pro Pro Pro His Leu Leu Ala Arg Ala 
225                 230                 235                 240 


Ala Lys Trp Glu Gln Ala Leu Pro Val Ala Leu Val Ser Ser Leu Glu 
                245                 250                 255     


Ala Gly Gly Arg Arg Arg Arg His Asp Gly Pro Pro Ala Gly Thr Gln 
            260                 265                 270         


Cys Pro Val Leu Arg Pro Glu Asp Val Leu Glu Ala Gly Ile His Gln 
        275                 280                 285             


Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp Thr Asp Glu Ser Arg 
    290                 295                 300                 


Tyr Pro Gln Lys Leu Ala Phe Ala Gln Cys Leu Cys Arg Gly Cys Val 
305                 310                 315                 320 


Ser Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu Asn Ser Val Pro Leu 
                325                 330                 335     


Leu Gln Ser Leu Leu Val Leu Arg Arg Gln Pro Cys Ser Arg Glu Ala 
            340                 345                 350         


Thr Gly Leu Pro Thr Pro Gly Ala Phe Ser Phe His Ala Glu Phe Ile 
        355                 360                 365             


Arg Val Pro Val Gly Cys Thr Cys Val Leu Pro Arg Ser Ala Arg Ala 
    370                 375                 380                 


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
385                 390                 395                 400 


Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Arg His Gly Pro 
                405                 410                 415     


Gln Leu Trp Gly Gly Pro His Ala His Gly Thr Pro Arg Cys Tyr Ser 
            420                 425                 430         


Ala Glu Glu Leu Pro Leu Gly Gln Pro Pro Pro His Leu Leu Ala Arg 
        435                 440                 445             


Ala Ala Lys Trp Glu Gln Ala Leu Pro Val Ala Leu Val Ser Ser Leu 
    450                 455                 460                 


Glu Ala Gly Gly Arg Arg Arg Arg His Asp Gly Pro Pro Ala Gly Thr 
465                 470                 475                 480 


Gln Cys Pro Val Leu Arg Pro Glu Asp Val Leu Glu Ala Gly Ile His 
                485                 490                 495     


Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp Thr Asp Glu Ser 
            500                 505                 510         


Arg Tyr Pro Gln Lys Leu Ala Phe Ala Gln Cys Leu Cys Arg Gly Cys 
        515                 520                 525             


Val Ser Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu Asn Ser Val Pro 
    530                 535                 540                 


Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Gln Pro Cys Ser Arg Glu 
545                 550                 555                 560 


Ala Thr Gly Leu Pro Thr Pro Gly Ala Phe Ser Phe His Ala Glu Phe 
                565                 570                 575     


Ile Arg Val Pro Val Gly Cys Thr Cys Val Leu Pro Arg Ser Ala Arg 
            580                 585                 590         


Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val 
        595                 600                 605             


Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile 
    610                 615                 620                 


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His 
625                 630                 635                 640 


His His 
        


<210>  271
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-17C polyprotein.

<400>  271

His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly Thr Pro 
1               5                   10                  15      


His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu Arg Pro 
    50                  55                  60                  


Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val Leu Glu 
65                  70                  75                  80  


Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Arg Pro 
    130                 135                 140                 


Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe Ala Phe 
145                 150                 155                 160 


His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Val Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
            180                 185                 190         


Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly His His Asp Pro Ser Leu 
        195                 200                 205             


Arg Gly His Pro His Ser His Gly Thr Pro His Cys Tyr Ser Ala Glu 
    210                 215                 220                 


Glu Leu Pro Leu Gly Gln Ala Pro Pro His Leu Leu Ala Arg Gly Ala 
225                 230                 235                 240 


Lys Trp Gly Gln Ala Leu Pro Val Ala Leu Val Ser Ser Leu Glu Ala 
                245                 250                 255     


Ala Ser His Arg Gly Arg His Glu Arg Pro Ser Ala Thr Thr Gln Cys 
            260                 265                 270         


Pro Val Leu Arg Pro Glu Glu Val Leu Glu Ala Asp Thr His Gln Arg 
        275                 280                 285             


Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp Thr Asp Glu Asp Arg Tyr 
    290                 295                 300                 


Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu Cys Arg Gly Cys Ile Asp 
305                 310                 315                 320 


Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu Asn Ser Val Arg Leu Leu 
                325                 330                 335     


Gln Ser Leu Leu Val Leu Arg Arg Arg Pro Cys Ser Arg Asp Gly Ser 
            340                 345                 350         


Gly Leu Pro Thr Pro Gly Ala Phe Ala Phe His Thr Glu Phe Ile His 
        355                 360                 365             


Val Pro Val Gly Cys Thr Cys Val Leu Pro Arg Ser Val Ala Gly Ser 
    370                 375                 380                 


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
385                 390                 395                 400 


Ser Ala Ser His Leu Glu Ser Gly Gly Ser His His Asp Pro Ser Leu 
                405                 410                 415     


Arg Gly His Pro His Ser His Gly Thr Pro His Cys Tyr Ser Ala Glu 
            420                 425                 430         


Glu Leu Pro Leu Gly Gln Ala Pro Pro His Leu Leu Ala Arg Gly Ala 
        435                 440                 445             


Lys Trp Gly Gln Ala Leu Pro Val Ala Leu Val Ser Ser Leu Glu Ala 
    450                 455                 460                 


Ala Ser His Arg Gly Arg His Glu Arg Pro Ser Ala Thr Thr Gln Cys 
465                 470                 475                 480 


Pro Val Leu Arg Pro Glu Glu Val Leu Glu Ala Asp Thr His Gln Arg 
                485                 490                 495     


Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp Thr Asp Glu Asp Arg Tyr 
            500                 505                 510         


Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu Cys Arg Gly Cys Ile Asp 
        515                 520                 525             


Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu Asn Ser Val Arg Leu Leu 
    530                 535                 540                 


Gln Ser Leu Leu Val Leu Arg Arg Arg Pro Cys Ser Arg Asp Gly Ser 
545                 550                 555                 560 


Gly Leu Pro Thr Pro Gly Ala Phe Ala Phe His Thr Glu Phe Ile His 
                565                 570                 575     


Val Pro Val Gly Cys Thr Cys Val Leu Pro Arg Ser Val Ala Gly Ser 
            580                 585                 590         


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
        595                 600                 605             


Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
    610                 615                 620                 


Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
625                 630                 635                 


<210>  272
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-17D polyprotein.

<400>  272

Ala Leu Arg Ala Ser Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala Glu 
1               5                   10                  15      


Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala Gly 
            20                  25                  30          


Val Leu Gly Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu Gln 
        35                  40                  45              


Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Gly Asp Arg Arg 
    50                  55                  60                  


Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr Arg 
65                  70                  75                  80  


Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Lys Tyr Leu Pro Glu Ala Tyr 
                85                  90                  95      


Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp Leu 
            100                 105                 110         


Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Ile Leu Arg Arg 
        115                 120                 125             


Thr Ser Ala Cys Ala Gly Gly Arg Trp Val Tyr Thr Glu Glu Tyr Val 
    130                 135                 140                 


Thr Val Pro Val Gly Cys Thr Cys Val Pro Glu Gln Glu Lys Glu Ala 
145                 150                 155                 160 


Asp Ala Val Asn Ser Ser Met Asp Lys Gln Gly Ala Arg Leu Leu Leu 
                165                 170                 175     


Gly Pro Gly Asp Lys Pro Gly Arg Pro Gly Ser Gly Gly Gln Tyr Ile 
            180                 185                 190         


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly 
        195                 200                 205             


Ala Leu Arg Ala Ser Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala Glu 
    210                 215                 220                 


Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala Gly 
225                 230                 235                 240 


Val Leu Gly Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu Gln 
                245                 250                 255     


Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Gly Asp Arg Arg 
            260                 265                 270         


Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr Arg 
        275                 280                 285             


Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Lys Tyr Leu Pro Glu Ala Tyr 
    290                 295                 300                 


Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp Leu 
305                 310                 315                 320 


Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Ile Leu Arg Arg 
                325                 330                 335     


Thr Ser Ala Cys Ala Gly Gly Arg Trp Val Tyr Thr Glu Glu Tyr Val 
            340                 345                 350         


Thr Val Pro Val Gly Cys Thr Cys Val Pro Glu Gln Glu Lys Glu Ala 
        355                 360                 365             


Asp Ala Val Asn Ser Ser Met Asp Lys Gln Gly Ala Arg Leu Leu Leu 
    370                 375                 380                 


Gly Pro Gly Asp Lys Pro Gly Arg Pro Ala Gly Ser Gly Phe Asn Asn 
385                 390                 395                 400 


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
                405                 410                 415     


Leu Glu Ser Gly Gly Ser Ala Leu Arg Ala Ser Arg Arg Pro Ala Arg 
            420                 425                 430         


Pro Arg Gly Cys Ala Glu Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr 
        435                 440                 445             


Gly Arg Leu Ala Ala Gly Val Leu Gly Ala Phe His His Thr Leu Gln 
    450                 455                 460                 


Leu Gly Pro Arg Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly 
465                 470                 475                 480 


Arg Pro Gly Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val 
                485                 490                 495     


Ser Pro Trp Ala Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Lys 
            500                 505                 510         


Tyr Leu Pro Glu Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu 
        515                 520                 525             


Phe Gly Glu Glu Asp Leu Arg Phe Arg Ser Ala Pro Val Tyr Met Pro 
    530                 535                 540                 


Thr Val Ile Leu Arg Arg Thr Ser Ala Cys Ala Gly Gly Arg Trp Val 
545                 550                 555                 560 


Tyr Thr Glu Glu Tyr Val Thr Val Pro Val Gly Cys Thr Cys Val Pro 
                565                 570                 575     


Glu Gln Glu Lys Glu Ala Asp Ala Val Asn Ser Ser Met Asp Lys Gln 
            580                 585                 590         


Gly Ala Arg Leu Leu Leu Gly Pro Gly Asp Lys Pro Gly Arg Pro Ala 
        595                 600                 605             


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
    610                 615                 620                 


Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys 
625                 630                 635                 640 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His 
                645                 650                 655     


His 
    


<210>  273
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-17D polyprotein.

<400>  273

Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys 
1               5                   10                  15      


Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala 
            20                  25                  30          


Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg 
        35                  40                  45              


Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp 
    50                  55                  60                  


Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala 
65                  70                  75                  80  


Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu 
                85                  90                  95      


Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu 
            100                 105                 110         


Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu 
        115                 120                 125             


Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala 
    130                 135                 140                 


Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys 
145                 150                 155                 160 


Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu 
                165                 170                 175     


Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro Gly Ser Gly Gly Gln 
            180                 185                 190         


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly 
        195                 200                 205             


Ser Gly Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg 
    210                 215                 220                 


Gly Cys Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg 
225                 230                 235                 240 


Leu Ala Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly 
                245                 250                 255     


Pro Arg Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro 
            260                 265                 270         


Ala Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro 
        275                 280                 285             


Trp Ala Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu 
    290                 295                 300                 


Pro Glu Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly 
305                 310                 315                 320 


Glu Glu Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val 
                325                 330                 335     


Val Leu Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr 
            340                 345                 350         


Glu Ala Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro 
        355                 360                 365             


Glu Lys Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala 
    370                 375                 380                 


Lys Leu Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro Ala Gly Ser 
385                 390                 395                 400 


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
                405                 410                 415     


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Ala Gly Ala Pro Arg Ala 
            420                 425                 430         


Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala Asp Arg Pro Glu Glu 
        435                 440                 445             


Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala Gly Val Leu Ser Ala 
    450                 455                 460                 


Phe His His Thr Leu Gln Leu Gly Pro Arg Glu Gln Ala Arg Asn Ala 
465                 470                 475                 480 


Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg Arg Phe Arg Pro Pro 
                485                 490                 495     


Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr Arg Ile Ser Tyr Asp 
            500                 505                 510         


Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala Tyr Cys Leu Cys Arg 
        515                 520                 525             


Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp Val Arg Phe Arg Ser 
    530                 535                 540                 


Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg Arg Thr Pro Ala Cys 
545                 550                 555                 560 


Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr Val Thr Ile Pro Val 
                565                 570                 575     


Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp Ala Asp Ser Ile Asn 
            580                 585                 590         


Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu Leu Gly Pro Asn Asp 
        595                 600                 605             


Ala Pro Ala Gly Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
    610                 615                 620                 


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser 
625                 630                 635                 640 


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
                645                 650                 655     


Leu His His His His His His 
            660             


<210>  274
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-17F polyprotein.

<400>  274

Arg Lys His Leu Lys Ala Gly Glu Thr Ala Leu Cys Pro Pro Leu Glu 
1               5                   10                  15      


Asp Asn Ser Val Arg Val Asp Ile Arg Ile Leu Arg Gln Asn Arg Gly 
            20                  25                  30          


Ile Ser Ile Ser Asn Asp Phe Gln Asn Arg Ser Ser Ser Pro Trp Asp 
        35                  40                  45              


Tyr Asn Ile Thr Arg Asp Pro His Arg Phe Pro Ser Glu Ile Ala Glu 
    50                  55                  60                  


Ala Gln Cys Arg His Ser Gly Cys Ile Asn Ala Glu Gly Gln Glu Asp 
65                  70                  75                  80  


Ser Ser Met Asn Ser Val Pro Ile Gln Gln Glu Phe Leu Val Leu Arg 
                85                  90                  95      


Arg Glu Pro Gln Gly Cys Ser Arg Ser Phe Arg Leu Glu Lys Val Leu 
            100                 105                 110         


Val Thr Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg Tyr Val Arg 
        115                 120                 125             


Ala Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
    130                 135                 140                 


Ile Thr Glu Leu Ala Gly Ser Gly Arg Lys His Leu Lys Ala Gly Glu 
145                 150                 155                 160 


Thr Ala Leu Cys Pro Pro Leu Glu Asp Asn Ser Val Arg Val Asp Ile 
                165                 170                 175     


Arg Ile Leu Arg Gln Asn Arg Gly Ile Ser Ile Ser Asn Asp Phe Gln 
            180                 185                 190         


Asn Arg Ser Ser Ser Pro Trp Asp Tyr Asn Ile Thr Arg Asp Pro His 
        195                 200                 205             


Arg Phe Pro Ser Glu Ile Ala Glu Ala Gln Cys Arg His Ser Gly Cys 
    210                 215                 220                 


Ile Asn Ala Glu Gly Gln Glu Asp Ser Ser Met Asn Ser Val Pro Ile 
225                 230                 235                 240 


Gln Gln Glu Phe Leu Val Leu Arg Arg Glu Pro Gln Gly Cys Ser Arg 
                245                 250                 255     


Ser Phe Arg Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val 
            260                 265                 270         


Thr Pro Ile Val Arg Tyr Val Arg Ala Ala Gly Ser Gly Phe Asn Asn 
        275                 280                 285             


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
    290                 295                 300                 


Leu Glu Ser Gly Gly Ser Arg Lys His Leu Lys Ala Gly Glu Thr Ala 
305                 310                 315                 320 


Leu Cys Pro Pro Leu Glu Asp Asn Ser Val Arg Val Asp Ile Arg Ile 
                325                 330                 335     


Leu Arg Gln Asn Arg Gly Ile Ser Ile Ser Asn Asp Phe Gln Asn Arg 
            340                 345                 350         


Ser Ser Ser Pro Trp Asp Tyr Asn Ile Thr Arg Asp Pro His Arg Phe 
        355                 360                 365             


Pro Ser Glu Ile Ala Glu Ala Gln Cys Arg His Ser Gly Cys Ile Asn 
    370                 375                 380                 


Ala Glu Gly Gln Glu Asp Ser Ser Met Asn Ser Val Pro Ile Gln Gln 
385                 390                 395                 400 


Glu Phe Leu Val Leu Arg Arg Glu Pro Gln Gly Cys Ser Arg Ser Phe 
                405                 410                 415     


Arg Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro 
            420                 425                 430         


Ile Val Arg Tyr Val Arg Ala Ala Gly Ser Gly Phe Asn Asn Phe Thr 
        435                 440                 445             


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
    450                 455                 460                 


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
465                 470                 475                 480 


Thr Glu Leu His His His His His His 
                485                 


<210>  275
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-17F polyprotein.

<400>  275

Arg Lys Asn Pro Lys Ala Gly Asp Thr Ala Leu Cys Pro Pro Leu Glu 
1               5                   10                  15      


Asp Asn Ser Val Arg Val Asp Ile Arg Ile Leu Arg Gln Asn Gln Gly 
            20                  25                  30          


Gly Ile Ser Ile Ser Asn Asp Phe Gln Asn Arg Ser Ser Ser Pro Trp 
        35                  40                  45              


Asp Tyr Asn Val Thr Arg Asp Pro Asn Arg Phe Pro Ser Glu Ile Val 
    50                  55                  60                  


Glu Ala Gln Cys Arg His Ser Gly Cys Ile Asn Ala Glu Gly Gln Glu 
65                  70                  75                  80  


Asp Ser Ser Met Asn Ser Val Pro Ile Gln Gln Glu Phe Leu Val Leu 
                85                  90                  95      


Arg Arg Glu Pro Gln Gly Cys Ser Arg Thr Phe Arg Leu Glu Lys Val 
            100                 105                 110         


Arg Val Thr Val Gly Cys Thr Cys Val Thr Pro Ile Val Arg Tyr Val 
        115                 120                 125             


Arg Ala Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
    130                 135                 140                 


Gly Ile Thr Glu Leu Ala Gly Ser Gly Arg Lys Asn Pro Lys Ala Gly 
145                 150                 155                 160 


Asp Thr Ala Leu Cys Pro Pro Leu Glu Asp Asn Ser Val Arg Val Asp 
                165                 170                 175     


Ile Arg Ile Leu Arg Gln Asn Gln Gly Gly Ile Ser Ile Ser Asn Asp 
            180                 185                 190         


Phe Gln Asn Arg Ser Ser Ser Pro Trp Asp Tyr Asn Val Thr Arg Asp 
        195                 200                 205             


Pro Asn Arg Phe Pro Ser Glu Ile Val Glu Ala Gln Cys Arg His Ser 
    210                 215                 220                 


Gly Cys Ile Asn Ala Glu Gly Gln Glu Asp Ser Ser Met Asn Ser Val 
225                 230                 235                 240 


Pro Ile Gln Gln Glu Phe Leu Val Leu Arg Arg Glu Pro Gln Gly Cys 
                245                 250                 255     


Ser Arg Thr Phe Arg Leu Glu Lys Val Arg Val Thr Val Gly Cys Thr 
            260                 265                 270         


Cys Val Thr Pro Ile Val Arg Tyr Val Arg Ala Ala Gly Ser Gly Phe 
        275                 280                 285             


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
    290                 295                 300                 


Ser His Leu Glu Ser Gly Gly Ser Arg Lys Asn Pro Lys Ala Gly Asp 
305                 310                 315                 320 


Thr Ala Leu Cys Pro Pro Leu Glu Asp Asn Ser Val Arg Val Asp Ile 
                325                 330                 335     


Arg Ile Leu Arg Gln Asn Gln Gly Gly Ile Ser Ile Ser Asn Asp Phe 
            340                 345                 350         


Gln Asn Arg Ser Ser Ser Pro Trp Asp Tyr Asn Val Thr Arg Asp Pro 
        355                 360                 365             


Asn Arg Phe Pro Ser Glu Ile Val Glu Ala Gln Cys Arg His Ser Gly 
    370                 375                 380                 


Cys Ile Asn Ala Glu Gly Gln Glu Asp Ser Ser Met Asn Ser Val Pro 
385                 390                 395                 400 


Ile Gln Gln Glu Phe Leu Val Leu Arg Arg Glu Pro Gln Gly Cys Ser 
                405                 410                 415     


Arg Thr Phe Arg Leu Glu Lys Val Arg Val Thr Val Gly Cys Thr Cys 
            420                 425                 430         


Val Thr Pro Ile Val Arg Tyr Val Arg Ala Ala Gly Ser Gly Phe Asn 
        435                 440                 445             


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
    450                 455                 460                 


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
465                 470                 475                 480 


Ile Gly Ile Thr Glu Leu His His His His His His 
                485                 490         


<210>  276
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-17F polyprotein.

<400>  276

Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val Gln Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    130                 135                 140                 


Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Arg Lys Ile Pro 
145                 150                 155                 160 


Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro Pro Val 
                165                 170                 175     


Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu Asn Gln 
            180                 185                 190         


Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser Pro Trp 
        195                 200                 205             


Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu Val Val 
    210                 215                 220                 


Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly Lys Glu 
225                 230                 235                 240 


Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu Val Val 
                245                 250                 255     


Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu Lys Val 
            260                 265                 270         


Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His His Val 
        275                 280                 285             


Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
    290                 295                 300                 


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Arg Lys 
305                 310                 315                 320 


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
                325                 330                 335     


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
            340                 345                 350         


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
        355                 360                 365             


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
    370                 375                 380                 


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
385                 390                 395                 400 


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
                405                 410                 415     


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
            420                 425                 430         


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
        435                 440                 445             


His Val Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
    450                 455                 460                 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly 
465                 470                 475                 480 


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His 
                485                 490                 495     


His His His His His 
            500     


<210>  277
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-18 polyprotein.

<400>  277

Tyr Phe Gly Lys Leu Glu Pro Lys Leu Ser Ile Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Val Asn Glu Gly Asn Gln Pro Val Phe Glu Asp 
            20                  25                  30          


Met Pro Asp Ser Asp Cys Thr Asp Asn Ala Pro His Thr Ile Phe Ile 
        35                  40                  45              


Ile Tyr Met Tyr Lys Asp Ser Leu Thr Arg Gly Leu Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Tyr Lys Thr Met Ser Thr Leu Ser Cys Lys Asn Lys Thr 
65                  70                  75                  80  


Ile Ser Phe Gln Lys Met Ser Pro Pro Asp Ser Ile Asn Asp Glu Gly 
                85                  90                  95      


Asn Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asp Lys 
            100                 105                 110         


Ile Gln Phe Glu Ser Ser Leu Tyr Lys Gly His Phe Leu Ala Cys Lys 
        115                 120                 125             


Lys Glu Asn Asp Leu Phe Lys Leu Ile Leu Lys Asp Lys Asp Glu Asn 
    130                 135                 140                 


Gly Asp Lys Ser Ile Met Phe Thr Val Gln Asn Lys Ser Gly Ser Gly 
145                 150                 155                 160 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                165                 170                 175     


Ala Gly Ser Gly Tyr Phe Gly Lys Leu Glu Pro Lys Leu Ser Ile Ile 
            180                 185                 190         


Arg Asn Leu Asn Asp Gln Val Leu Phe Val Asn Glu Gly Asn Gln Pro 
        195                 200                 205             


Val Phe Glu Asp Met Pro Asp Ser Asp Cys Thr Asp Asn Ala Pro His 
    210                 215                 220                 


Thr Ile Phe Ile Ile Tyr Met Tyr Lys Asp Ser Leu Thr Arg Gly Leu 
225                 230                 235                 240 


Ala Val Thr Ile Ser Val Lys Tyr Lys Thr Met Ser Thr Leu Ser Cys 
                245                 250                 255     


Lys Asn Lys Thr Ile Ser Phe Gln Lys Met Ser Pro Pro Asp Ser Ile 
            260                 265                 270         


Asn Asp Glu Gly Asn Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
        275                 280                 285             


His Asp Asp Lys Ile Gln Phe Glu Ser Ser Leu Tyr Lys Gly His Phe 
    290                 295                 300                 


Leu Ala Cys Lys Lys Glu Asn Asp Leu Phe Lys Leu Ile Leu Lys Asp 
305                 310                 315                 320 


Lys Asp Glu Asn Gly Asp Lys Ser Ile Met Phe Thr Val Gln Asn Lys 
                325                 330                 335     


Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
            340                 345                 350         


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Tyr Phe 
        355                 360                 365             


Gly Lys Leu Glu Pro Lys Leu Ser Ile Ile Arg Asn Leu Asn Asp Gln 
    370                 375                 380                 


Val Leu Phe Val Asn Glu Gly Asn Gln Pro Val Phe Glu Asp Met Pro 
385                 390                 395                 400 


Asp Ser Asp Cys Thr Asp Asn Ala Pro His Thr Ile Phe Ile Ile Tyr 
                405                 410                 415     


Met Tyr Lys Asp Ser Leu Thr Arg Gly Leu Ala Val Thr Ile Ser Val 
            420                 425                 430         


Lys Tyr Lys Thr Met Ser Thr Leu Ser Cys Lys Asn Lys Thr Ile Ser 
        435                 440                 445             


Phe Gln Lys Met Ser Pro Pro Asp Ser Ile Asn Asp Glu Gly Asn Asp 
    450                 455                 460                 


Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asp Lys Ile Gln 
465                 470                 475                 480 


Phe Glu Ser Ser Leu Tyr Lys Gly His Phe Leu Ala Cys Lys Lys Glu 
                485                 490                 495     


Asn Asp Leu Phe Lys Leu Ile Leu Lys Asp Lys Asp Glu Asn Gly Asp 
            500                 505                 510         


Lys Ser Ile Met Phe Thr Val Gln Asn Lys Ser Ala Gly Ser Gly Phe 
        515                 520                 525             


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
    530                 535                 540                 


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
545                 550                 555                 560 


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
                565                 570             


<210>  278
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-18 polyprotein.

<400>  278

Tyr Phe Gly Lys Leu Glu His Lys Leu Ser Ile Leu Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asn Gln Gly Asp Gln Pro Val Phe Glu Asp 
            20                  25                  30          


Met Pro Asp Ser Asp Cys Thr Asp Asn Ala Pro Arg Thr Glu Phe Ile 
        35                  40                  45              


Ile Tyr Met Tyr Lys Asp Ser Leu Thr Arg Gly Leu Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Asn Tyr Lys Thr Met Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Ser Pro Pro Glu Ser Ile Asn Asp Glu Gly 
                85                  90                  95      


Asn Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asp Lys 
            100                 105                 110         


Ile Gln Phe Glu Ser Ser Leu Tyr Lys Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Lys Asp Leu Phe Lys Leu Ile Leu Lys Lys Lys Asp Glu Asn 
    130                 135                 140                 


Gly Asp Lys Ser Ile Met Phe Thr Val Gln Asn Lys Asn Gly Ser Gly 
145                 150                 155                 160 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                165                 170                 175     


Ala Gly Ser Gly Tyr Phe Gly Lys Leu Glu His Lys Leu Ser Ile Leu 
            180                 185                 190         


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asn Gln Gly Asp Gln Pro 
        195                 200                 205             


Val Phe Glu Asp Met Pro Asp Ser Asp Cys Thr Asp Asn Ala Pro Arg 
    210                 215                 220                 


Thr Glu Phe Ile Ile Tyr Met Tyr Lys Asp Ser Leu Thr Arg Gly Leu 
225                 230                 235                 240 


Ala Val Thr Ile Ser Val Asn Tyr Lys Thr Met Ser Thr Leu Ser Cys 
                245                 250                 255     


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Ser Pro Pro Glu Ser Ile 
            260                 265                 270         


Asn Asp Glu Gly Asn Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
        275                 280                 285             


His Asp Asp Lys Ile Gln Phe Glu Ser Ser Leu Tyr Lys Gly Tyr Phe 
    290                 295                 300                 


Leu Ala Cys Glu Lys Glu Lys Asp Leu Phe Lys Leu Ile Leu Lys Lys 
305                 310                 315                 320 


Lys Asp Glu Asn Gly Asp Lys Ser Ile Met Phe Thr Val Gln Asn Lys 
                325                 330                 335     


Asn Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
            340                 345                 350         


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Tyr Phe 
        355                 360                 365             


Gly Lys Leu Glu His Lys Leu Ser Ile Leu Arg Asn Leu Asn Asp Gln 
    370                 375                 380                 


Val Leu Phe Ile Asn Gln Gly Asp Gln Pro Val Phe Glu Asp Met Pro 
385                 390                 395                 400 


Asp Ser Asp Cys Thr Asp Asn Ala Pro Arg Thr Glu Phe Ile Ile Tyr 
                405                 410                 415     


Met Tyr Lys Asp Ser Leu Thr Arg Gly Leu Ala Val Thr Ile Ser Val 
            420                 425                 430         


Asn Tyr Lys Thr Met Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile Ser 
        435                 440                 445             


Phe Lys Glu Met Ser Pro Pro Glu Ser Ile Asn Asp Glu Gly Asn Asp 
    450                 455                 460                 


Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asp Lys Ile Gln 
465                 470                 475                 480 


Phe Glu Ser Ser Leu Tyr Lys Gly Tyr Phe Leu Ala Cys Glu Lys Glu 
                485                 490                 495     


Lys Asp Leu Phe Lys Leu Ile Leu Lys Lys Lys Asp Glu Asn Gly Asp 
            500                 505                 510         


Lys Ser Ile Met Phe Thr Val Gln Asn Lys Asn Ala Gly Ser Gly Phe 
        515                 520                 525             


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
    530                 535                 540                 


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
545                 550                 555                 560 


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
                565                 570             


<210>  279
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-18 polyprotein.

<400>  279

Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Gly Ser Gly 
145                 150                 155                 160 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                165                 170                 175     


Ala Gly Ser Gly Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
            180                 185                 190         


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
        195                 200                 205             


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
    210                 215                 220                 


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
225                 230                 235                 240 


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
                245                 250                 255     


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
            260                 265                 270         


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
        275                 280                 285             


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
    290                 295                 300                 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
305                 310                 315                 320 


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
                325                 330                 335     


Asp Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
            340                 345                 350         


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Tyr Phe 
        355                 360                 365             


Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn Asp Gln 
    370                 375                 380                 


Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp Met Thr 
385                 390                 395                 400 


Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile Ile Ser 
                405                 410                 415     


Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile Ser Val 
            420                 425                 430         


Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile Ile Ser 
        435                 440                 445             


Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys Ser Asp 
    450                 455                 460                 


Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys Met Gln 
465                 470                 475                 480 


Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu Lys Glu 
                485                 490                 495     


Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu Gly Asp 
            500                 505                 510         


Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Ala Gly Ser Gly Phe 
        515                 520                 525             


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
    530                 535                 540                 


Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
545                 550                 555                 560 


Phe Ile Gly Ile Thr Glu Leu His His His His His His 
                565                 570             


<210>  280
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-19 polyprotein.

<400>  280

Leu Arg Arg Cys Leu Ile Ser Thr Asp Met His His Ile Glu Glu Ser 
1               5                   10                  15      


Phe Gln Glu Ile Lys Arg Ala Ile Gln Ala Lys Asp Thr Phe Pro Asn 
            20                  25                  30          


Val Thr Ile Leu Ser Thr Leu Glu Thr Leu Gln Ile Ile Lys Pro Leu 
        35                  40                  45              


Asp Val Cys Cys Val Thr Lys Asn Leu Leu Ala Phe Tyr Val Asp Arg 
    50                  55                  60                  


Val Phe Lys Asp His Gln Glu Pro Asn Pro Lys Ile Leu Arg Lys Ile 
65                  70                  75                  80  


Ser Ser Ile Ala Asn Ser Phe Leu Tyr Met Gln Lys Thr Leu Arg Gln 
                85                  90                  95      


Cys Gln Glu Gln Arg Gln Cys His Cys Arg Gln Glu Ala Thr Asn Ala 
            100                 105                 110         


Thr Arg Val Ile His Asp Asn Tyr Asp Gln Leu Glu Val His Ala Ala 
        115                 120                 125             


Ala Ile Lys Ser Leu Gly Glu Leu Asp Val Phe Leu Ala Trp Ile Asn 
    130                 135                 140                 


Lys Asn His Glu Val Met Phe Ser Ala Gly Ser Gly Gly Gln Tyr Ile 
145                 150                 155                 160 


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly 
                165                 170                 175     


Leu Arg Arg Cys Leu Ile Ser Thr Asp Met His His Ile Glu Glu Ser 
            180                 185                 190         


Phe Gln Glu Ile Lys Arg Ala Ile Gln Ala Lys Asp Thr Phe Pro Asn 
        195                 200                 205             


Val Thr Ile Leu Ser Thr Leu Glu Thr Leu Gln Ile Ile Lys Pro Leu 
    210                 215                 220                 


Asp Val Cys Cys Val Thr Lys Asn Leu Leu Ala Phe Tyr Val Asp Arg 
225                 230                 235                 240 


Val Phe Lys Asp His Gln Glu Pro Asn Pro Lys Ile Leu Arg Lys Ile 
                245                 250                 255     


Ser Ser Ile Ala Asn Ser Phe Leu Tyr Met Gln Lys Thr Leu Arg Gln 
            260                 265                 270         


Cys Gln Glu Gln Arg Gln Cys His Cys Arg Gln Glu Ala Thr Asn Ala 
        275                 280                 285             


Thr Arg Val Ile His Asp Asn Tyr Asp Gln Leu Glu Val His Ala Ala 
    290                 295                 300                 


Ala Ile Lys Ser Leu Gly Glu Leu Asp Val Phe Leu Ala Trp Ile Asn 
305                 310                 315                 320 


Lys Asn His Glu Val Met Phe Ser Ala Ala Gly Ser Gly Phe Asn Asn 
                325                 330                 335     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            340                 345                 350         


Leu Glu Ser Gly Gly Ser Leu Arg Arg Cys Leu Ile Ser Thr Asp Met 
        355                 360                 365             


His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile Gln Ala 
    370                 375                 380                 


Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu Thr Leu 
385                 390                 395                 400 


Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn Leu Leu 
                405                 410                 415     


Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro Asn Pro 
            420                 425                 430         


Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu Tyr Met 
        435                 440                 445             


Gln Lys Thr Leu Arg Gln Cys Gln Glu Gln Arg Gln Cys His Cys Arg 
    450                 455                 460                 


Gln Glu Ala Thr Asn Ala Thr Arg Val Ile His Asp Asn Tyr Asp Gln 
465                 470                 475                 480 


Leu Glu Val His Ala Ala Ala Ile Lys Ser Leu Gly Glu Leu Asp Val 
                485                 490                 495     


Phe Leu Ala Trp Ile Asn Lys Asn His Glu Val Met Phe Ser Ala Ala 
            500                 505                 510         


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
        515                 520                 525             


Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys 
    530                 535                 540                 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His 
545                 550                 555                 560 


His 
    


<210>  281
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-20 polyprotein.

<400>  281

Leu Lys Thr Leu Asn Leu Gly Ser Cys Val Ile Ala Thr Asn Leu Gln 
1               5                   10                  15      


Glu Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val Gln Ala Lys 
            20                  25                  30          


Asp Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu Ser Leu Gln 
        35                  40                  45              


Asp Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His Leu Leu Arg 
    50                  55                  60                  


Leu Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro Asp His Tyr 
65                  70                  75                  80  


Thr Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu Thr Ile Lys 
                85                  90                  95      


Lys Asp Leu Arg Leu Cys His Ala His Met Thr Cys His Cys Gly Glu 
            100                 105                 110         


Glu Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe Glu Lys Leu 
        115                 120                 125             


Glu Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu Asp Ile Leu 
    130                 135                 140                 


Leu Gln Trp Met Glu Glu Thr Glu Gly Ser Gly Gly Gln Tyr Ile Lys 
145                 150                 155                 160 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Leu 
                165                 170                 175     


Lys Thr Leu Asn Leu Gly Ser Cys Val Ile Ala Thr Asn Leu Gln Glu 
            180                 185                 190         


Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser Val Gln Ala Lys Asp 
        195                 200                 205             


Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr Glu Ser Leu Gln Asp 
    210                 215                 220                 


Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg His Leu Leu Arg Leu 
225                 230                 235                 240 


Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr Pro Asp His Tyr Thr 
                245                 250                 255     


Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe Leu Thr Ile Lys Lys 
            260                 265                 270         


Asp Leu Arg Leu Cys His Ala His Met Thr Cys His Cys Gly Glu Glu 
        275                 280                 285             


Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His Phe Glu Lys Leu Glu 
    290                 295                 300                 


Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gln Trp Met Glu Glu Thr Glu Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                325                 330                 335     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            340                 345                 350         


Ser Gly Gly Ser Leu Lys Thr Leu Asn Leu Gly Ser Cys Val Ile Ala 
        355                 360                 365             


Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu Ile Arg Gly Ser 
    370                 375                 380                 


Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile Leu Arg Arg Thr 
385                 390                 395                 400 


Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys Cys Leu Leu Arg 
                405                 410                 415     


His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys Asn Tyr Gln Thr 
            420                 425                 430         


Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu Ala Asn Ser Phe 
        435                 440                 445             


Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala His Met Thr Cys 
    450                 455                 460                 


His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln Ile Leu Ser His 
465                 470                 475                 480 


Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu 
                485                 490                 495     


Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu Ala Gly Ser Gly 
            500                 505                 510         


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
        515                 520                 525             


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    530                 535                 540                 


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
545                 550                 555             


<210>  282
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-21 polyprotein.

<400>  282

His Lys Ser Ser Phe Gln Glu Gln Asp Leu Leu Leu Ile Arg Met Arg 
1               5                   10                  15      


Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu 
            20                  25                  30          


Asp Pro Glu Ser Leu Pro Ala Pro Glu Asp Val Lys Arg His Cys Glu 
        35                  40                  45              


Arg Ser Ala Phe Ser Cys Phe Gln Lys Val Gln Leu Lys Ala Ala Asn 
    50                  55                  60                  


Thr Gly Gly Asn Glu Gln Ile Ile Asn Val Leu Thr Lys Gln Leu Lys 
65                  70                  75                  80  


Arg Lys Leu Pro Pro Thr Asn Ala Gly Arg Arg Gln Lys His Arg Pro 
                85                  90                  95      


Ala Cys Pro Ser Cys Asp Ser Tyr Glu Lys Ala Pro Pro Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Ser Leu Ile Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Ser Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
    130                 135                 140                 


Ile Thr Glu Leu Ala Gly Ser Gly His Lys Ser Ser Phe Gln Glu Gln 
145                 150                 155                 160 


Asp Leu Leu Leu Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
                165                 170                 175     


Leu Lys Asn Tyr Val Asn Asp Leu Asp Pro Glu Ser Leu Pro Ala Pro 
            180                 185                 190         


Glu Asp Val Lys Arg His Cys Glu Arg Ser Ala Phe Ser Cys Phe Gln 
        195                 200                 205             


Lys Val Gln Leu Lys Ala Ala Asn Thr Gly Gly Asn Glu Gln Ile Ile 
    210                 215                 220                 


Asn Val Leu Thr Lys Gln Leu Lys Arg Lys Leu Pro Pro Thr Asn Ala 
225                 230                 235                 240 


Gly Arg Arg Gln Lys His Arg Pro Ala Cys Pro Ser Cys Asp Ser Tyr 
                245                 250                 255     


Glu Lys Ala Pro Pro Lys Glu Phe Leu Glu Arg Leu Lys Ser Leu Ile 
            260                 265                 270         


Gln Lys Met Ile His Gln His Leu Ser Ala Gly Ser Gly Phe Asn Asn 
        275                 280                 285             


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
    290                 295                 300                 


Leu Glu Ser Gly Gly Ser His Lys Ser Ser Phe Gln Glu Gln Asp Leu 
305                 310                 315                 320 


Leu Leu Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys 
                325                 330                 335     


Asn Tyr Val Asn Asp Leu Asp Pro Glu Ser Leu Pro Ala Pro Glu Asp 
            340                 345                 350         


Val Lys Arg His Cys Glu Arg Ser Ala Phe Ser Cys Phe Gln Lys Val 
        355                 360                 365             


Gln Leu Lys Ala Ala Asn Thr Gly Gly Asn Glu Gln Ile Ile Asn Val 
    370                 375                 380                 


Leu Thr Lys Gln Leu Lys Arg Lys Leu Pro Pro Thr Asn Ala Gly Arg 
385                 390                 395                 400 


Arg Gln Lys His Arg Pro Ala Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
                405                 410                 415     


Ala Pro Pro Lys Glu Phe Leu Glu Arg Leu Lys Ser Leu Ile Gln Lys 
            420                 425                 430         


Met Ile His Gln His Leu Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr 
        435                 440                 445             


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
    450                 455                 460                 


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
465                 470                 475                 480 


Thr Glu Leu His His His His His His 
                485                 


<210>  283
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-21 polyprotein.

<400>  283

His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg 
1               5                   10                  15      


Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu 
            20                  25                  30          


Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu 
        35                  40                  45              


Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn 
    50                  55                  60                  


Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys 
65                  70                  75                  80  


Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu 
                85                  90                  95      


Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly Ser Gly Gly Gln Tyr 
    130                 135                 140                 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser 
145                 150                 155                 160 


Gly His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg Met 
                165                 170                 175     


Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp 
            180                 185                 190         


Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys 
        195                 200                 205             


Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala 
    210                 215                 220                 


Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu 
225                 230                 235                 240 


Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg 
                245                 250                 255     


Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu 
            260                 265                 270         


Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His 
        275                 280                 285             


Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Ala Gly Ser Gly Phe 
    290                 295                 300                 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
305                 310                 315                 320 


Ser His Leu Glu Ser Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln 
                325                 330                 335     


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
            340                 345                 350         


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
        355                 360                 365             


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
    370                 375                 380                 


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
385                 390                 395                 400 


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
                405                 410                 415     


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
            420                 425                 430         


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
        435                 440                 445             


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
    450                 455                 460                 


Asp Ser Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu 
465                 470                 475                 480 


Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln 
                485                 490                 495     


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His 
            500                 505                 510         


His His His His 
        515     


<210>  284
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-22 polyprotein.

<400>  284

Leu Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Asn Met Gly Glu Arg Cys Tyr Leu Met Lys Glu Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Leu Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Lys Leu 
                85                  90                  95      


Ser Gln Cys His Ile Glu Asn Asp Asp Gln His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Gln Lys Leu Gly Glu Asn Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ala Leu Arg Asn Ala 
    130                 135                 140                 


Cys Val Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
145                 150                 155                 160 


Gly Ile Thr Glu Leu Ala Gly Ser Gly Leu Pro Ile Ser Ser His Cys 
                165                 170                 175     


Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr 
            180                 185                 190         


Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val 
        195                 200                 205             


Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Asn Met Gly Glu Arg 
    210                 215                 220                 


Cys Tyr Leu Met Lys Glu Val Leu Asn Phe Thr Leu Glu Glu Val Leu 
225                 230                 235                 240 


Leu Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro 
                245                 250                 255     


Phe Leu Ala Arg Leu Ser Asn Lys Leu Ser Gln Cys His Ile Glu Asn 
            260                 265                 270         


Asp Asp Gln His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val 
        275                 280                 285             


Gln Lys Leu Gly Glu Asn Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp 
    290                 295                 300                 


Leu Leu Phe Met Ala Leu Arg Asn Ala Cys Val Ala Gly Ser Gly Phe 
305                 310                 315                 320 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
                325                 330                 335     


Ser His Leu Glu Ser Gly Gly Ser Leu Pro Ile Ser Ser His Cys Arg 
            340                 345                 350         


Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe 
        355                 360                 365             


Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg 
    370                 375                 380                 


Leu Ile Gly Glu Lys Leu Phe His Gly Val Asn Met Gly Glu Arg Cys 
385                 390                 395                 400 


Tyr Leu Met Lys Glu Val Leu Asn Phe Thr Leu Glu Glu Val Leu Leu 
                405                 410                 415     


Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe 
            420                 425                 430         


Leu Ala Arg Leu Ser Asn Lys Leu Ser Gln Cys His Ile Glu Asn Asp 
        435                 440                 445             


Asp Gln His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val Gln 
    450                 455                 460                 


Lys Leu Gly Glu Asn Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu 
465                 470                 475                 480 


Leu Phe Met Ala Leu Arg Asn Ala Cys Val Ala Gly Ser Gly Phe Asn 
                485                 490                 495     


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
            500                 505                 510         


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
        515                 520                 525             


Ile Gly Ile Thr Glu Leu His His His His His His 
    530                 535                 540 


<210>  285
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-22 polyprotein.

<400>  285

Val Pro Ile Ser Ser His Cys Arg Leu Asp Gly Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe Tyr 
        35                  40                  45              


Glu Val Asn Met Gly Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Leu Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Lys Leu 
                85                  90                  95      


Ser Gln Cys His Ile Asp Ser Asp Asp Gln His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Asn Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Asn Gly Glu Ile 
        115                 120                 125             


Lys Val Ile Gly Glu Leu Asp Leu Leu Phe Met Ala Leu Arg Asn Ala 
    130                 135                 140                 


Cys Asn Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
145                 150                 155                 160 


Gly Ile Thr Glu Leu Ala Gly Ser Gly Val Pro Ile Ser Ser His Cys 
                165                 170                 175     


Arg Leu Asp Gly Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr 
            180                 185                 190         


Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val 
        195                 200                 205             


Arg Leu Ile Gly Glu Lys Leu Phe Tyr Glu Val Asn Met Gly Glu Arg 
    210                 215                 220                 


Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu 
225                 230                 235                 240 


Leu Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro 
                245                 250                 255     


Phe Leu Ala Arg Leu Ser Asn Lys Leu Ser Gln Cys His Ile Asp Ser 
            260                 265                 270         


Asp Asp Gln His Ile Gln Arg Asn Val Gln Asn Leu Lys Asp Thr Val 
        275                 280                 285             


Lys Lys Leu Gly Glu Asn Gly Glu Ile Lys Val Ile Gly Glu Leu Asp 
    290                 295                 300                 


Leu Leu Phe Met Ala Leu Arg Asn Ala Cys Asn Ala Gly Ser Gly Phe 
305                 310                 315                 320 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
                325                 330                 335     


Ser His Leu Glu Ser Gly Gly Ser Val Pro Ile Ser Ser His Cys Arg 
            340                 345                 350         


Leu Asp Gly Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe 
        355                 360                 365             


Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg 
    370                 375                 380                 


Leu Ile Gly Glu Lys Leu Phe Tyr Glu Val Asn Met Gly Glu Arg Cys 
385                 390                 395                 400 


Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu Leu 
                405                 410                 415     


Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe 
            420                 425                 430         


Leu Ala Arg Leu Ser Asn Lys Leu Ser Gln Cys His Ile Asp Ser Asp 
        435                 440                 445             


Asp Gln His Ile Gln Arg Asn Val Gln Asn Leu Lys Asp Thr Val Lys 
    450                 455                 460                 


Lys Leu Gly Glu Asn Gly Glu Ile Lys Val Ile Gly Glu Leu Asp Leu 
465                 470                 475                 480 


Leu Phe Met Ala Leu Arg Asn Ala Cys Asn Ala Gly Ser Gly Phe Asn 
                485                 490                 495     


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
            500                 505                 510         


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
        515                 520                 525             


Ile Gly Ile Thr Glu Leu His His His His His His 
    530                 535                 540 


<210>  286
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-22 polyprotein.

<400>  286

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
145                 150                 155                 160 


Gly Ile Thr Glu Leu Ala Gly Ser Gly Ala Pro Ile Ser Ser His Cys 
                165                 170                 175     


Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr 
            180                 185                 190         


Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val 
        195                 200                 205             


Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg 
    210                 215                 220                 


Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu 
225                 230                 235                 240 


Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro 
                245                 250                 255     


Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly 
            260                 265                 270         


Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val 
        275                 280                 285             


Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp 
    290                 295                 300                 


Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile Ala Gly Ser Gly Phe 
305                 310                 315                 320 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
                325                 330                 335     


Ser His Leu Glu Ser Gly Gly Ser Ala Pro Ile Ser Ser His Cys Arg 
            340                 345                 350         


Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe 
        355                 360                 365             


Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg 
    370                 375                 380                 


Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg Cys 
385                 390                 395                 400 


Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu Phe 
                405                 410                 415     


Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe 
            420                 425                 430         


Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp 
        435                 440                 445             


Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val Lys 
    450                 455                 460                 


Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu 
465                 470                 475                 480 


Leu Phe Met Ser Leu Arg Asn Ala Cys Ile Ala Gly Ser Gly Phe Asn 
                485                 490                 495     


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
            500                 505                 510         


His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
        515                 520                 525             


Ile Gly Ile Thr Glu Leu His His His His His His 
    530                 535                 540 


<210>  287
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-24 polyprotein.

<400>  287

Gln Glu Phe Arg Phe Gly Pro Cys Arg Val Gln Gly Val Ala Leu Arg 
1               5                   10                  15      


Glu Leu Arg Glu Ala Phe Trp Thr Val Lys Asp Thr Val Gln Ala Lys 
            20                  25                  30          


Asp Asn Ile Thr Ser Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asp 
        35                  40                  45              


Val Ser Gln Glu Asp Glu Met Phe Ser Ile Ser Glu Ser Ala Arg Arg 
    50                  55                  60                  


Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met 
                85                  90                  95      


Glu Lys Phe Tyr Glu Phe Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
            100                 105                 110         


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Gln Glu Phe 
        115                 120                 125             


Arg Phe Gly Pro Cys Arg Val Gln Gly Val Ala Leu Arg Glu Leu Arg 
    130                 135                 140                 


Glu Ala Phe Trp Thr Val Lys Asp Thr Val Gln Ala Lys Asp Asn Ile 
145                 150                 155                 160 


Thr Ser Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asp Val Ser Gln 
                165                 170                 175     


Glu Asp Glu Met Phe Ser Ile Ser Glu Ser Ala Arg Arg Arg Phe Leu 
            180                 185                 190         


Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Gln Ala Ala Gln Thr 
        195                 200                 205             


Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met Glu Lys Phe 
    210                 215                 220                 


Tyr Glu Phe Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
225                 230                 235                 240 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
                245                 250                 255     


Gln Glu Phe Arg Phe Gly Pro Cys Arg Val Gln Gly Val Ala Leu Arg 
            260                 265                 270         


Glu Leu Arg Glu Ala Phe Trp Thr Val Lys Asp Thr Val Gln Ala Lys 
        275                 280                 285             


Asp Asn Ile Thr Ser Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asp 
    290                 295                 300                 


Val Ser Gln Glu Asp Glu Met Phe Ser Ile Ser Glu Ser Ala Arg Arg 
305                 310                 315                 320 


Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Gln Ala 
                325                 330                 335     


Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met 
            340                 345                 350         


Glu Lys Phe Tyr Glu Phe Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
        355                 360                 365             


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
    370                 375                 380                 


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
385                 390                 395                 400 


Glu Leu His His His His His His 
                405             


<210>  288
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-24 Family polyprotein.

<400>  288

Gln Glu Phe Arg Phe Gly Pro Cys Arg Val Gln Gly Val Ala Leu Arg 
1               5                   10                  15      


Glu Leu Arg Glu Ala Phe Trp Thr Val Lys Asp Thr Val Gln Ala Lys 
            20                  25                  30          


Asp Asn Ile Thr Ser Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asp 
        35                  40                  45              


Val Ser Asp Ala Glu Ser Cys Tyr Leu Ile Arg Ala Leu Leu Lys Phe 
    50                  55                  60                  


Tyr Leu Asn Thr Val Phe Lys Asn Tyr Leu Asp Glu Ala Ala Asp Val 
65                  70                  75                  80  


Arg Ile Arg Arg Ser Phe Ser Thr Leu Ala Asn Asn Phe Phe Val Ile 
                85                  90                  95      


Ala Ser Lys Leu Gln Pro Ser Gln Glu Asp Glu Met Phe Ser Ile Ser 
            100                 105                 110         


Glu Ser Ala Arg Arg Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln 
        115                 120                 125             


Leu Asp Ile Gln Ala Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile 
    130                 135                 140                 


Leu Leu Thr Trp Met Glu Lys Phe Tyr Glu Phe Gly Ser Gly Gly Gln 
145                 150                 155                 160 


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly 
                165                 170                 175     


Ser Gly Gln Glu Phe Arg Phe Gly Pro Cys Arg Val Gln Gly Val Ala 
            180                 185                 190         


Leu Arg Glu Leu Arg Glu Ala Phe Trp Thr Val Lys Asp Thr Val Gln 
        195                 200                 205             


Ala Lys Asp Asn Ile Thr Ser Val Arg Leu Leu Arg Lys Glu Val Leu 
    210                 215                 220                 


Gln Asp Val Ser Asp Ala Glu Ser Cys Tyr Leu Ile Arg Ala Leu Leu 
225                 230                 235                 240 


Lys Phe Tyr Leu Asn Thr Val Phe Lys Asn Tyr Leu Asp Glu Ala Ala 
                245                 250                 255     


Asp Val Arg Ile Arg Arg Ser Phe Ser Thr Leu Ala Asn Asn Phe Phe 
            260                 265                 270         


Val Ile Ala Ser Lys Leu Gln Pro Ser Gln Glu Asp Glu Met Phe Ser 
        275                 280                 285             


Ile Ser Glu Ser Ala Arg Arg Arg Phe Leu Leu Phe Gln Arg Ala Phe 
    290                 295                 300                 


Lys Gln Leu Asp Ile Gln Ala Ala Gln Thr Lys Ala Phe Gly Glu Val 
305                 310                 315                 320 


Asp Ile Leu Leu Thr Trp Met Glu Lys Phe Tyr Glu Phe Ala Gly Ser 
                325                 330                 335     


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
            340                 345                 350         


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Gln Glu Phe Arg Phe Gly 
        355                 360                 365             


Pro Cys Arg Val Gln Gly Val Ala Leu Arg Glu Leu Arg Glu Ala Phe 
    370                 375                 380                 


Trp Thr Val Lys Asp Thr Val Gln Ala Lys Asp Asn Ile Thr Ser Val 
385                 390                 395                 400 


Arg Leu Leu Arg Lys Glu Val Leu Gln Asp Val Ser Asp Ala Glu Ser 
                405                 410                 415     


Cys Tyr Leu Ile Arg Ala Leu Leu Lys Phe Tyr Leu Asn Thr Val Phe 
            420                 425                 430         


Lys Asn Tyr Leu Asp Glu Ala Ala Asp Val Arg Ile Arg Arg Ser Phe 
        435                 440                 445             


Ser Thr Leu Ala Asn Asn Phe Phe Val Ile Ala Ser Lys Leu Gln Pro 
    450                 455                 460                 


Ser Gln Glu Asp Glu Met Phe Ser Ile Ser Glu Ser Ala Arg Arg Arg 
465                 470                 475                 480 


Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Gln Ala Ala 
                485                 490                 495     


Gln Thr Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met Glu 
            500                 505                 510         


Lys Phe Tyr Glu Phe Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
        515                 520                 525             


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser 
    530                 535                 540                 


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
545                 550                 555                 560 


Leu His His His His His His 
                565         


<210>  289
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-24 polyprotein.

<400>  289

Gln Glu Phe Gln Phe Gly Pro Cys Arg Val Glu Gly Val Val Leu Gln 
1               5                   10                  15      


Glu Leu Trp Glu Ala Phe Trp Ala Met Lys Asp Ile Val Gln Ala Lys 
            20                  25                  30          


Asp Asn Ile Thr Asn Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asn 
        35                  40                  45              


Val Ser Gln Glu Asn Glu Met Phe Ser Val Ser Asp Ser Ala Arg Arg 
    50                  55                  60                  


Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Glu Ala 
65                  70                  75                  80  


Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met 
                85                  90                  95      


Glu Lys Phe Tyr Gln Leu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
            100                 105                 110         


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Gln Glu Phe 
        115                 120                 125             


Gln Phe Gly Pro Cys Arg Val Glu Gly Val Val Leu Gln Glu Leu Trp 
    130                 135                 140                 


Glu Ala Phe Trp Ala Met Lys Asp Ile Val Gln Ala Lys Asp Asn Ile 
145                 150                 155                 160 


Thr Asn Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asn Val Ser Gln 
                165                 170                 175     


Glu Asn Glu Met Phe Ser Val Ser Asp Ser Ala Arg Arg Arg Phe Leu 
            180                 185                 190         


Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Glu Ala Ala Gln Thr 
        195                 200                 205             


Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met Glu Lys Phe 
    210                 215                 220                 


Tyr Gln Leu Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
225                 230                 235                 240 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
                245                 250                 255     


Gln Glu Phe Gln Phe Gly Pro Cys Arg Val Glu Gly Val Val Leu Gln 
            260                 265                 270         


Glu Leu Trp Glu Ala Phe Trp Ala Met Lys Asp Ile Val Gln Ala Lys 
        275                 280                 285             


Asp Asn Ile Thr Asn Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asn 
    290                 295                 300                 


Val Ser Gln Glu Asn Glu Met Phe Ser Val Ser Asp Ser Ala Arg Arg 
305                 310                 315                 320 


Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Glu Ala 
                325                 330                 335     


Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met 
            340                 345                 350         


Glu Lys Phe Tyr Gln Leu Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
        355                 360                 365             


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
    370                 375                 380                 


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
385                 390                 395                 400 


Glu Leu His His His His His His 
                405             


<210>  290
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-24 Family polyprotein.

<400>  290

Gln Glu Phe Gln Phe Gly Pro Cys Arg Val Glu Gly Val Val Leu Gln 
1               5                   10                  15      


Glu Leu Trp Glu Ala Phe Trp Ala Met Lys Asp Ile Val Gln Ala Lys 
            20                  25                  30          


Asp Asn Ile Thr Asn Val Arg Leu Leu Arg Lys Glu Val Leu Gln Asn 
        35                  40                  45              


Val Ser Asn Ala Glu Ser Cys Tyr Leu Ile Arg Ala Leu Leu Lys Phe 
    50                  55                  60                  


Tyr Leu Asn Thr Val Phe Lys Asn Tyr Gln Asp Lys Ala Ala Asp Phe 
65                  70                  75                  80  


Arg Val Arg Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe Val Val Ile 
                85                  90                  95      


Val Ser Lys Leu Gln Pro Ser Gln Glu Asn Glu Met Phe Ser Val Ser 
            100                 105                 110         


Asp Ser Ala Arg Arg Arg Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln 
        115                 120                 125             


Leu Asp Ile Glu Ala Ala Gln Thr Lys Ala Phe Gly Glu Val Asp Ile 
    130                 135                 140                 


Leu Leu Thr Trp Met Glu Lys Phe Tyr Gln Leu Gly Ser Gly Gly Gln 
145                 150                 155                 160 


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly 
                165                 170                 175     


Ser Gly Gln Glu Phe Gln Phe Gly Pro Cys Arg Val Glu Gly Val Val 
            180                 185                 190         


Leu Gln Glu Leu Trp Glu Ala Phe Trp Ala Met Lys Asp Ile Val Gln 
        195                 200                 205             


Ala Lys Asp Asn Ile Thr Asn Val Arg Leu Leu Arg Lys Glu Val Leu 
    210                 215                 220                 


Gln Asn Val Ser Asn Ala Glu Ser Cys Tyr Leu Ile Arg Ala Leu Leu 
225                 230                 235                 240 


Lys Phe Tyr Leu Asn Thr Val Phe Lys Asn Tyr Gln Asp Lys Ala Ala 
                245                 250                 255     


Asp Phe Arg Val Arg Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe Val 
            260                 265                 270         


Val Ile Val Ser Lys Leu Gln Pro Ser Gln Glu Asn Glu Met Phe Ser 
        275                 280                 285             


Val Ser Asp Ser Ala Arg Arg Arg Phe Leu Leu Phe Gln Arg Ala Phe 
    290                 295                 300                 


Lys Gln Leu Asp Ile Glu Ala Ala Gln Thr Lys Ala Phe Gly Glu Val 
305                 310                 315                 320 


Asp Ile Leu Leu Thr Trp Met Glu Lys Phe Tyr Gln Leu Ala Gly Ser 
                325                 330                 335     


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
            340                 345                 350         


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Gln Glu Phe Gln Phe Gly 
        355                 360                 365             


Pro Cys Arg Val Glu Gly Val Val Leu Gln Glu Leu Trp Glu Ala Phe 
    370                 375                 380                 


Trp Ala Met Lys Asp Ile Val Gln Ala Lys Asp Asn Ile Thr Asn Val 
385                 390                 395                 400 


Arg Leu Leu Arg Lys Glu Val Leu Gln Asn Val Ser Asn Ala Glu Ser 
                405                 410                 415     


Cys Tyr Leu Ile Arg Ala Leu Leu Lys Phe Tyr Leu Asn Thr Val Phe 
            420                 425                 430         


Lys Asn Tyr Gln Asp Lys Ala Ala Asp Phe Arg Val Arg Lys Ser Phe 
        435                 440                 445             


Ser Thr Leu Ala Asn Asn Phe Val Val Ile Val Ser Lys Leu Gln Pro 
    450                 455                 460                 


Ser Gln Glu Asn Glu Met Phe Ser Val Ser Asp Ser Ala Arg Arg Arg 
465                 470                 475                 480 


Phe Leu Leu Phe Gln Arg Ala Phe Lys Gln Leu Asp Ile Glu Ala Ala 
                485                 490                 495     


Gln Thr Lys Ala Phe Gly Glu Val Asp Ile Leu Leu Thr Trp Met Glu 
            500                 505                 510         


Lys Phe Tyr Gln Leu Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
        515                 520                 525             


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser 
    530                 535                 540                 


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
545                 550                 555                 560 


Leu His His His His His His 
                565         


<210>  291
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-24 polyprotein.

<400>  291

Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly Val Val Pro Gln 
1               5                   10                  15      


Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr Met Gln Ala Gln 
            20                  25                  30          


Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu Val Leu Gln Asn 
        35                  40                  45              


Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr Leu Leu Glu Phe 
    50                  55                  60                  


Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg Thr Val Glu Val 
65                  70                  75                  80  


Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe Val Leu Ile 
                85                  90                  95      


Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met Phe Ser Ile Arg 
            100                 105                 110         


Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala Phe Lys Gln 
        115                 120                 125             


Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu Val Asp Ile 
    130                 135                 140                 


Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu Gly Ser Gly Gly Gln 
145                 150                 155                 160 


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly 
                165                 170                 175     


Ser Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly Val Val 
            180                 185                 190         


Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr Met Gln 
        195                 200                 205             


Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu Val Leu 
    210                 215                 220                 


Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr Leu Leu 
225                 230                 235                 240 


Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg Thr Val 
                245                 250                 255     


Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe Val 
            260                 265                 270         


Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met Phe Ser 
        275                 280                 285             


Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala Phe 
    290                 295                 300                 


Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu Val 
305                 310                 315                 320 


Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu Ala Gly Ser 
                325                 330                 335     


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
            340                 345                 350         


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Gln Glu Phe His Phe Gly 
        355                 360                 365             


Pro Cys Gln Val Lys Gly Val Val Pro Gln Lys Leu Trp Glu Ala Phe 
    370                 375                 380                 


Trp Ala Val Lys Asp Thr Met Gln Ala Gln Asp Asn Ile Thr Ser Ala 
385                 390                 395                 400 


Arg Leu Leu Gln Gln Glu Val Leu Gln Asn Val Ser Asp Ala Glu Ser 
                405                 410                 415     


Cys Tyr Leu Val His Thr Leu Leu Glu Phe Tyr Leu Lys Thr Val Phe 
            420                 425                 430         


Lys Asn Tyr His Asn Arg Thr Val Glu Val Arg Thr Leu Lys Ser Phe 
        435                 440                 445             


Ser Thr Leu Ala Asn Asn Phe Val Leu Ile Val Ser Gln Leu Gln Pro 
    450                 455                 460                 


Ser Gln Glu Asn Glu Met Phe Ser Ile Arg Asp Ser Ala His Arg Arg 
465                 470                 475                 480 


Phe Leu Leu Phe Arg Arg Ala Phe Lys Gln Leu Asp Val Glu Ala Ala 
                485                 490                 495     


Leu Thr Lys Ala Leu Gly Glu Val Asp Ile Leu Leu Thr Trp Met Gln 
            500                 505                 510         


Lys Phe Tyr Lys Leu Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
        515                 520                 525             


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser 
    530                 535                 540                 


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
545                 550                 555                 560 


Leu His His His His His His 
                565         


<210>  292
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-25 polyprotein.

<400>  292

Cys Thr His Trp Pro Asn Cys Cys Pro Ser Lys Arg Gln Asp Pro Thr 
1               5                   10                  15      


His Glu Trp Leu Lys Arg Asp Thr Val Leu Lys Phe Pro Gly Glu Thr 
            20                  25                  30          


Thr Ser Leu Thr His His Pro Glu Ser Cys Lys Ala Ser Glu Asp Gly 
        35                  40                  45              


Pro Leu Asn Ser Arg Ser Ile Ser Pro Trp Lys Tyr Glu Leu Asp Arg 
    50                  55                  60                  


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
65                  70                  75                  80  


Gln His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Leu Gly 
                85                  90                  95      


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
            100                 105                 110         


Cys Pro Gly Glu Gln Gly Ala Pro Asp Gly Tyr Cys Leu Glu Gln Arg 
        115                 120                 125             


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
    130                 135                 140                 


Ala Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
145                 150                 155                 160 


Ile Thr Glu Leu Ala Gly Ser Gly Cys Thr His Trp Pro Asn Cys Cys 
                165                 170                 175     


Pro Ser Lys Arg Gln Asp Pro Thr His Glu Trp Leu Lys Arg Asp Thr 
            180                 185                 190         


Val Leu Lys Phe Pro Gly Glu Thr Thr Ser Leu Thr His His Pro Glu 
        195                 200                 205             


Ser Cys Lys Ala Ser Glu Asp Gly Pro Leu Asn Ser Arg Ser Ile Ser 
    210                 215                 220                 


Pro Trp Lys Tyr Glu Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp 
225                 230                 235                 240 


Leu Tyr His Ala Arg Cys Leu Cys Gln His Cys Val Ser Leu Gln Thr 
                245                 250                 255     


Gly Ser His Met Asp Pro Leu Gly Asn Ser Glu Leu Leu Tyr His Asn 
            260                 265                 270         


Gln Thr Val Phe Tyr Arg Arg Pro Cys Pro Gly Glu Gln Gly Ala Pro 
        275                 280                 285             


Asp Gly Tyr Cys Leu Glu Gln Arg Leu Tyr Arg Val Ser Leu Ala Cys 
    290                 295                 300                 


Val Cys Val Arg Pro Arg Val Met Ala Ala Gly Ser Gly Phe Asn Asn 
305                 310                 315                 320 


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
                325                 330                 335     


Leu Glu Ser Gly Gly Ser Cys Thr His Trp Pro Asn Cys Cys Pro Ser 
            340                 345                 350         


Lys Arg Gln Asp Pro Thr His Glu Trp Leu Lys Arg Asp Thr Val Leu 
        355                 360                 365             


Lys Phe Pro Gly Glu Thr Thr Ser Leu Thr His His Pro Glu Ser Cys 
    370                 375                 380                 


Lys Ala Ser Glu Asp Gly Pro Leu Asn Ser Arg Ser Ile Ser Pro Trp 
385                 390                 395                 400 


Lys Tyr Glu Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr 
                405                 410                 415     


His Ala Arg Cys Leu Cys Gln His Cys Val Ser Leu Gln Thr Gly Ser 
            420                 425                 430         


His Met Asp Pro Leu Gly Asn Ser Glu Leu Leu Tyr His Asn Gln Thr 
        435                 440                 445             


Val Phe Tyr Arg Arg Pro Cys Pro Gly Glu Gln Gly Ala Pro Asp Gly 
    450                 455                 460                 


Tyr Cys Leu Glu Gln Arg Leu Tyr Arg Val Ser Leu Ala Cys Val Cys 
465                 470                 475                 480 


Val Arg Pro Arg Val Met Ala Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                485                 490                 495     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            500                 505                 510         


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
        515                 520                 525             


Thr Glu Leu His His His His His His 
    530                 535         


<210>  293
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-25 polyprotein.

<400>  293

Leu Ser His Trp Ser Ser Cys Cys Pro Ser Lys Gly Gln Asn Pro Thr 
1               5                   10                  15      


His Glu Trp Leu Thr Glu Asn Thr Val Leu Met Thr Pro Pro Glu Ser 
            20                  25                  30          


Ala Ser Leu Ile His Ser Leu Glu Ser Cys Arg Ala Ser Glu Asp Gly 
        35                  40                  45              


Pro Leu Asn Ser Arg Ser Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
    50                  55                  60                  


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
65                  70                  75                  80  


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Leu Gly 
                85                  90                  95      


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
            100                 105                 110         


Cys Pro Gly Glu Gln Gly Thr Arg Asp Gly Tyr Cys Leu Glu Gln Arg 
        115                 120                 125             


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
    130                 135                 140                 


Ala Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
145                 150                 155                 160 


Ile Thr Glu Leu Ala Gly Ser Gly Leu Ser His Trp Ser Ser Cys Cys 
                165                 170                 175     


Pro Ser Lys Gly Gln Asn Pro Thr His Glu Trp Leu Thr Glu Asn Thr 
            180                 185                 190         


Val Leu Met Thr Pro Pro Glu Ser Ala Ser Leu Ile His Ser Leu Glu 
        195                 200                 205             


Ser Cys Arg Ala Ser Glu Asp Gly Pro Leu Asn Ser Arg Ser Ile Ser 
    210                 215                 220                 


Pro Trp Arg Tyr Glu Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp 
225                 230                 235                 240 


Leu Tyr His Ala Arg Cys Leu Cys Pro His Cys Val Ser Leu Gln Thr 
                245                 250                 255     


Gly Ser His Met Asp Pro Leu Gly Asn Ser Glu Leu Leu Tyr His Asn 
            260                 265                 270         


Gln Thr Val Phe Tyr Arg Arg Pro Cys Pro Gly Glu Gln Gly Thr Arg 
        275                 280                 285             


Asp Gly Tyr Cys Leu Glu Gln Arg Leu Tyr Arg Val Ser Leu Ala Cys 
    290                 295                 300                 


Val Cys Val Arg Pro Arg Val Met Ala Ala Gly Ser Gly Phe Asn Asn 
305                 310                 315                 320 


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
                325                 330                 335     


Leu Glu Ser Gly Gly Ser Leu Ser His Trp Ser Ser Cys Cys Pro Ser 
            340                 345                 350         


Lys Gly Gln Asn Pro Thr His Glu Trp Leu Thr Glu Asn Thr Val Leu 
        355                 360                 365             


Met Thr Pro Pro Glu Ser Ala Ser Leu Ile His Ser Leu Glu Ser Cys 
    370                 375                 380                 


Arg Ala Ser Glu Asp Gly Pro Leu Asn Ser Arg Ser Ile Ser Pro Trp 
385                 390                 395                 400 


Arg Tyr Glu Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr 
                405                 410                 415     


His Ala Arg Cys Leu Cys Pro His Cys Val Ser Leu Gln Thr Gly Ser 
            420                 425                 430         


His Met Asp Pro Leu Gly Asn Ser Glu Leu Leu Tyr His Asn Gln Thr 
        435                 440                 445             


Val Phe Tyr Arg Arg Pro Cys Pro Gly Glu Gln Gly Thr Arg Asp Gly 
    450                 455                 460                 


Tyr Cys Leu Glu Gln Arg Leu Tyr Arg Val Ser Leu Ala Cys Val Cys 
465                 470                 475                 480 


Val Arg Pro Arg Val Met Ala Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                485                 490                 495     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            500                 505                 510         


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
        515                 520                 525             


Thr Glu Leu His His His His His His 
    530                 535         


<210>  294
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-25 polyprotein.

<400>  294

Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
1               5                   10                  15      


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
            20                  25                  30          


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
        35                  40                  45              


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
    50                  55                  60                  


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
65                  70                  75                  80  


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
                85                  90                  95      


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
            100                 105                 110         


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
        115                 120                 125             


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
145                 150                 155                 160 


Ile Thr Glu Leu Ala Gly Ser Gly Tyr Ser His Trp Pro Ser Cys Cys 
                165                 170                 175     


Pro Ser Lys Gly Gln Asp Thr Ser Glu Glu Leu Leu Arg Trp Ser Thr 
            180                 185                 190         


Val Pro Val Pro Pro Leu Glu Pro Ala Arg Pro Asn Arg His Pro Glu 
        195                 200                 205             


Ser Cys Arg Ala Ser Glu Asp Gly Pro Leu Asn Ser Arg Ala Ile Ser 
    210                 215                 220                 


Pro Trp Arg Tyr Glu Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp 
225                 230                 235                 240 


Leu Tyr His Ala Arg Cys Leu Cys Pro His Cys Val Ser Leu Gln Thr 
                245                 250                 255     


Gly Ser His Met Asp Pro Arg Gly Asn Ser Glu Leu Leu Tyr His Asn 
            260                 265                 270         


Gln Thr Val Phe Tyr Arg Arg Pro Cys His Gly Glu Lys Gly Thr His 
        275                 280                 285             


Lys Gly Tyr Cys Leu Glu Arg Arg Leu Tyr Arg Val Ser Leu Ala Cys 
    290                 295                 300                 


Val Cys Val Arg Pro Arg Val Met Gly Ala Gly Ser Gly Phe Asn Asn 
305                 310                 315                 320 


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
                325                 330                 335     


Leu Glu Ser Gly Gly Ser Tyr Ser His Trp Pro Ser Cys Cys Pro Ser 
            340                 345                 350         


Lys Gly Gln Asp Thr Ser Glu Glu Leu Leu Arg Trp Ser Thr Val Pro 
        355                 360                 365             


Val Pro Pro Leu Glu Pro Ala Arg Pro Asn Arg His Pro Glu Ser Cys 
    370                 375                 380                 


Arg Ala Ser Glu Asp Gly Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp 
385                 390                 395                 400 


Arg Tyr Glu Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr 
                405                 410                 415     


His Ala Arg Cys Leu Cys Pro His Cys Val Ser Leu Gln Thr Gly Ser 
            420                 425                 430         


His Met Asp Pro Arg Gly Asn Ser Glu Leu Leu Tyr His Asn Gln Thr 
        435                 440                 445             


Val Phe Tyr Arg Arg Pro Cys His Gly Glu Lys Gly Thr His Lys Gly 
    450                 455                 460                 


Tyr Cys Leu Glu Arg Arg Leu Tyr Arg Val Ser Leu Ala Cys Val Cys 
465                 470                 475                 480 


Val Arg Pro Arg Val Met Gly Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                485                 490                 495     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            500                 505                 510         


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
        515                 520                 525             


Thr Glu Leu His His His His His His 
    530                 535         


<210>  295
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-26 polyprotein.

<400>  295

Lys His Lys Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Gln Ala Val Asp Thr Leu Tyr Val Lys Ala Ala Trp Leu Lys 
            20                  25                  30          


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Arg Lys 
        35                  40                  45              


Lys Thr Lys Asn Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu 
    50                  55                  60                  


Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln Leu Gln Leu Lys Ile 
65                  70                  75                  80  


Cys Arg Glu Ile Arg Phe Val Glu Glu Leu His Ser Leu Arg Gln Gln 
                85                  90                  95      


Leu Ser Arg Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Thr 
            100                 105                 110         


Ile Thr Arg Met Lys Ser Thr Phe Tyr Gly Leu Gly Asn Lys Gly Ile 
        115                 120                 125             


Tyr Lys Ala Ile Ser Glu Leu Asn Ile Leu Leu Ser Trp Ile Lys Gln 
    130                 135                 140                 


Phe Leu Glu Ser Ile Lys Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
145                 150                 155                 160 


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Lys His Lys 
                165                 170                 175     


Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr Leu Ser Gln 
            180                 185                 190         


Ala Val Asp Thr Leu Tyr Val Lys Ala Ala Trp Leu Lys Ala Thr Ile 
        195                 200                 205             


Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Arg Lys Lys Thr Lys 
    210                 215                 220                 


Asn Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu Leu Ser Phe 
225                 230                 235                 240 


Phe Met Glu Asp Val Phe Gly Gln Leu Gln Leu Lys Ile Cys Arg Glu 
                245                 250                 255     


Ile Arg Phe Val Glu Glu Leu His Ser Leu Arg Gln Gln Leu Ser Arg 
            260                 265                 270         


Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Thr Ile Thr Arg 
        275                 280                 285             


Met Lys Ser Thr Phe Tyr Gly Leu Gly Asn Lys Gly Ile Tyr Lys Ala 
    290                 295                 300                 


Ile Ser Glu Leu Asn Ile Leu Leu Ser Trp Ile Lys Gln Phe Leu Glu 
305                 310                 315                 320 


Ser Ile Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
                325                 330                 335     


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
            340                 345                 350         


Lys His Lys Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr 
        355                 360                 365             


Leu Ser Gln Ala Val Asp Thr Leu Tyr Val Lys Ala Ala Trp Leu Lys 
    370                 375                 380                 


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Arg Lys 
385                 390                 395                 400 


Lys Thr Lys Asn Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu 
                405                 410                 415     


Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln Leu Gln Leu Lys Ile 
            420                 425                 430         


Cys Arg Glu Ile Arg Phe Val Glu Glu Leu His Ser Leu Arg Gln Gln 
        435                 440                 445             


Leu Ser Arg Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Thr 
    450                 455                 460                 


Ile Thr Arg Met Lys Ser Thr Phe Tyr Gly Leu Gly Asn Lys Gly Ile 
465                 470                 475                 480 


Tyr Lys Ala Ile Ser Glu Leu Asn Ile Leu Leu Ser Trp Ile Lys Gln 
                485                 490                 495     


Phe Leu Glu Ser Ile Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
            500                 505                 510         


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
        515                 520                 525             


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
    530                 535                 540                 


Glu Leu His His His His His His 
545                 550         


<210>  296
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-26 polyprotein.

<400>  296

Lys His Lys Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Gln Ala Val Asp Arg Leu Tyr Val Lys Ala Ala Trp Leu Lys 
            20                  25                  30          


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys 
        35                  40                  45              


Lys Thr Lys Lys Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu 
    50                  55                  60                  


Leu Ser Phe Phe Met Asp Asp Val Phe Gly Gln Leu Gln Leu Gln Val 
65                  70                  75                  80  


Cys Lys Glu Arg His Phe Val Glu Glu Phe His Ser Leu Arg Gln Gln 
                85                  90                  95      


Leu Ser Arg Cys Val Leu Ser Trp Val Arg Lys Thr Ser Leu Ile Lys 
            100                 105                 110         


Ser Pro Val Ser Gly Ala Cys Thr Leu Leu Thr Gly Arg Glu Met Gly 
        115                 120                 125             


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
    130                 135                 140                 


Glu Leu Ala Gly Ser Gly Lys His Lys Gln Ser Ser Ser Ala Lys Gly 
145                 150                 155                 160 


Cys Tyr Pro Arg Gly Thr Leu Ser Gln Ala Val Asp Arg Leu Tyr Val 
                165                 170                 175     


Lys Ala Ala Trp Leu Lys Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn 
            180                 185                 190         


Ile Arg Leu Leu Lys Lys Lys Thr Lys Lys Leu Phe Met Lys Asn Cys 
        195                 200                 205             


Arg Phe Gln Glu Gln Leu Leu Ser Phe Phe Met Asp Asp Val Phe Gly 
    210                 215                 220                 


Gln Leu Gln Leu Gln Val Cys Lys Glu Arg His Phe Val Glu Glu Phe 
225                 230                 235                 240 


His Ser Leu Arg Gln Gln Leu Ser Arg Cys Val Leu Ser Trp Val Arg 
                245                 250                 255     


Lys Thr Ser Leu Ile Lys Ser Pro Val Ser Gly Ala Cys Thr Leu Leu 
            260                 265                 270         


Thr Gly Arg Glu Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
        275                 280                 285             


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
    290                 295                 300                 


Gly Ser Lys His Lys Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg 
305                 310                 315                 320 


Gly Thr Leu Ser Gln Ala Val Asp Arg Leu Tyr Val Lys Ala Ala Trp 
                325                 330                 335     


Leu Lys Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu 
            340                 345                 350         


Lys Lys Lys Thr Lys Lys Leu Phe Met Lys Asn Cys Arg Phe Gln Glu 
        355                 360                 365             


Gln Leu Leu Ser Phe Phe Met Asp Asp Val Phe Gly Gln Leu Gln Leu 
    370                 375                 380                 


Gln Val Cys Lys Glu Arg His Phe Val Glu Glu Phe His Ser Leu Arg 
385                 390                 395                 400 


Gln Gln Leu Ser Arg Cys Val Leu Ser Trp Val Arg Lys Thr Ser Leu 
                405                 410                 415     


Ile Lys Ser Pro Val Ser Gly Ala Cys Thr Leu Leu Thr Gly Arg Glu 
            420                 425                 430         


Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
        435                 440                 445             


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
    450                 455                 460                 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
465                 470                 475                 480 


His His His 
            


<210>  297
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-26 family polyprotein.

<400>  297

Lys His Lys Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Gln Ala Val Asp Arg Leu Tyr Val Lys Ala Ala Trp Leu Lys 
            20                  25                  30          


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys 
        35                  40                  45              


Lys Thr Lys Lys Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu 
    50                  55                  60                  


Leu Ser Phe Phe Met Asp Asp Val Phe Gly Gln Leu Gln Leu Gln Val 
65                  70                  75                  80  


Cys Lys Glu Arg His Phe Val Glu Glu Phe His Ser Leu Arg Gln Gln 
                85                  90                  95      


Leu Ser Arg Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Thr 
            100                 105                 110         


Ile Thr Arg Met Lys Arg Thr Phe Tyr Gly Ile Gly Asn Lys Gly Ile 
        115                 120                 125             


Tyr Lys Ala Val Ser Glu Leu Asp Ile Leu Leu Ser Trp Ile Lys Gln 
    130                 135                 140                 


Phe Leu Glu Ser Ile Lys Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
145                 150                 155                 160 


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Lys His Lys 
                165                 170                 175     


Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr Leu Ser Gln 
            180                 185                 190         


Ala Val Asp Arg Leu Tyr Val Lys Ala Ala Trp Leu Lys Ala Thr Ile 
        195                 200                 205             


Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys Lys Thr Lys 
    210                 215                 220                 


Lys Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu Leu Ser Phe 
225                 230                 235                 240 


Phe Met Asp Asp Val Phe Gly Gln Leu Gln Leu Gln Val Cys Lys Glu 
                245                 250                 255     


Arg His Phe Val Glu Glu Phe His Ser Leu Arg Gln Gln Leu Ser Arg 
            260                 265                 270         


Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Thr Ile Thr Arg 
        275                 280                 285             


Met Lys Arg Thr Phe Tyr Gly Ile Gly Asn Lys Gly Ile Tyr Lys Ala 
    290                 295                 300                 


Val Ser Glu Leu Asp Ile Leu Leu Ser Trp Ile Lys Gln Phe Leu Glu 
305                 310                 315                 320 


Ser Ile Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
                325                 330                 335     


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
            340                 345                 350         


Lys His Lys Gln Ser Ser Ser Ala Lys Gly Cys Tyr Pro Arg Gly Thr 
        355                 360                 365             


Leu Ser Gln Ala Val Asp Arg Leu Tyr Val Lys Ala Ala Trp Leu Lys 
    370                 375                 380                 


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys 
385                 390                 395                 400 


Lys Thr Lys Lys Leu Phe Met Lys Asn Cys Arg Phe Gln Glu Gln Leu 
                405                 410                 415     


Leu Ser Phe Phe Met Asp Asp Val Phe Gly Gln Leu Gln Leu Gln Val 
            420                 425                 430         


Cys Lys Glu Arg His Phe Val Glu Glu Phe His Ser Leu Arg Gln Gln 
        435                 440                 445             


Leu Ser Arg Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Thr 
    450                 455                 460                 


Ile Thr Arg Met Lys Arg Thr Phe Tyr Gly Ile Gly Asn Lys Gly Ile 
465                 470                 475                 480 


Tyr Lys Ala Val Ser Glu Leu Asp Ile Leu Leu Ser Trp Ile Lys Gln 
                485                 490                 495     


Phe Leu Glu Ser Ile Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
            500                 505                 510         


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
        515                 520                 525             


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
    530                 535                 540                 


Glu Leu His His His His His His 
545                 550         


<210>  298
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-26 polyprotein.

<400>  298

Lys His Lys Gln Ser Ser Phe Thr Lys Ser Cys Tyr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Gln Ala Val Asp Ala Leu Tyr Ile Lys Ala Ala Trp Leu Lys 
            20                  25                  30          


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys 
        35                  40                  45              


Lys Thr Lys Lys Gln Phe Met Lys Asn Cys Gln Phe Gln Glu Gln Leu 
    50                  55                  60                  


Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln Leu Gln Leu Gln Gly 
65                  70                  75                  80  


Cys Lys Lys Ile Arg Phe Val Glu Asp Phe His Ser Leu Arg Gln Lys 
                85                  90                  95      


Leu Ser His Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Ser 
            100                 105                 110         


Ile Thr Arg Met Lys Arg Ile Phe Tyr Arg Ile Gly Asn Lys Gly Ile 
        115                 120                 125             


Tyr Lys Ala Ile Ser Glu Leu Asp Ile Leu Leu Ser Trp Ile Lys Lys 
    130                 135                 140                 


Leu Leu Glu Ser Ser Gln Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
145                 150                 155                 160 


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Lys His Lys 
                165                 170                 175     


Gln Ser Ser Phe Thr Lys Ser Cys Tyr Pro Arg Gly Thr Leu Ser Gln 
            180                 185                 190         


Ala Val Asp Ala Leu Tyr Ile Lys Ala Ala Trp Leu Lys Ala Thr Ile 
        195                 200                 205             


Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys Lys Thr Lys 
    210                 215                 220                 


Lys Gln Phe Met Lys Asn Cys Gln Phe Gln Glu Gln Leu Leu Ser Phe 
225                 230                 235                 240 


Phe Met Glu Asp Val Phe Gly Gln Leu Gln Leu Gln Gly Cys Lys Lys 
                245                 250                 255     


Ile Arg Phe Val Glu Asp Phe His Ser Leu Arg Gln Lys Leu Ser His 
            260                 265                 270         


Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Ser Ile Thr Arg 
        275                 280                 285             


Met Lys Arg Ile Phe Tyr Arg Ile Gly Asn Lys Gly Ile Tyr Lys Ala 
    290                 295                 300                 


Ile Ser Glu Leu Asp Ile Leu Leu Ser Trp Ile Lys Lys Leu Leu Glu 
305                 310                 315                 320 


Ser Ser Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
                325                 330                 335     


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
            340                 345                 350         


Lys His Lys Gln Ser Ser Phe Thr Lys Ser Cys Tyr Pro Arg Gly Thr 
        355                 360                 365             


Leu Ser Gln Ala Val Asp Ala Leu Tyr Ile Lys Ala Ala Trp Leu Lys 
    370                 375                 380                 


Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile Arg Leu Leu Lys Lys 
385                 390                 395                 400 


Lys Thr Lys Lys Gln Phe Met Lys Asn Cys Gln Phe Gln Glu Gln Leu 
                405                 410                 415     


Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln Leu Gln Leu Gln Gly 
            420                 425                 430         


Cys Lys Lys Ile Arg Phe Val Glu Asp Phe His Ser Leu Arg Gln Lys 
        435                 440                 445             


Leu Ser His Cys Ile Ser Cys Ala Ser Ser Ala Arg Glu Met Lys Ser 
    450                 455                 460                 


Ile Thr Arg Met Lys Arg Ile Phe Tyr Arg Ile Gly Asn Lys Gly Ile 
465                 470                 475                 480 


Tyr Lys Ala Ile Ser Glu Leu Asp Ile Leu Leu Ser Trp Ile Lys Lys 
                485                 490                 495     


Leu Leu Glu Ser Ser Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
            500                 505                 510         


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
        515                 520                 525             


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
    530                 535                 540                 


Glu Leu His His His His His His 
545                 550         


<210>  299
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-27 polyprotein.

<400>  299

Phe Pro Arg Pro Pro Gly Arg Ser Pro Leu Ser Leu Gln Glu Leu Arg 
1               5                   10                  15      


Arg Glu Phe Lys Val Ser Leu Gln Leu Ala Lys Lys Leu Phe Ser Glu 
            20                  25                  30          


Val Arg Ile Gln Ala His His Phe Ala Glu Ser Gln Leu Pro Gly Val 
        35                  40                  45              


Ser Leu Asp Leu Leu Pro Leu Gly Asp Gln Leu Pro Asn Val Ser Leu 
    50                  55                  60                  


Pro Phe Gln Ala Trp His Ser Leu Ser Asp Pro Glu Arg Leu Cys Phe 
65                  70                  75                  80  


Leu Ser Met Met Leu His Pro Phe His Ala Leu Leu Glu Ser Leu Gly 
                85                  90                  95      


Ser Gln Gly Gly Trp Thr Ser Ser Glu Lys Met His Leu Trp Thr Met 
            100                 105                 110         


Arg Leu Asp Leu Arg Asp Leu Gln Arg His Leu Arg Phe Gln Val Glu 
        115                 120                 125             


Tyr Pro Pro Thr Cys Ser Thr Pro Arg Asp Gln His Thr Lys Leu Lys 
    130                 135                 140                 


Leu Ile Gly Ser Leu Leu Lys Thr Ser Pro Ala Gln Arg Leu Gly Lys 
145                 150                 155                 160 


Phe Gly Gly Arg Cys Ser Arg Ser Ser Val Cys Val Cys Val Cys Val 
                165                 170                 175     


Cys Val Cys Val Cys Val Cys Pro Arg Pro Arg Leu Cys Ser Leu Asn 
            180                 185                 190         


Leu Cys Leu Pro Met Glu Ser Trp Ser Glu Gln Leu Gly Ser Gly Gly 
        195                 200                 205             


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala 
    210                 215                 220                 


Gly Ser Gly Phe Pro Arg Pro Pro Gly Arg Ser Pro Leu Ser Leu Gln 
225                 230                 235                 240 


Glu Leu Arg Arg Glu Phe Lys Val Ser Leu Gln Leu Ala Lys Lys Leu 
                245                 250                 255     


Phe Ser Glu Val Arg Ile Gln Ala His His Phe Ala Glu Ser Gln Leu 
            260                 265                 270         


Pro Gly Val Ser Leu Asp Leu Leu Pro Leu Gly Asp Gln Leu Pro Asn 
        275                 280                 285             


Val Ser Leu Pro Phe Gln Ala Trp His Ser Leu Ser Asp Pro Glu Arg 
    290                 295                 300                 


Leu Cys Phe Leu Ser Met Met Leu His Pro Phe His Ala Leu Leu Glu 
305                 310                 315                 320 


Ser Leu Gly Ser Gln Gly Gly Trp Thr Ser Ser Glu Lys Met His Leu 
                325                 330                 335     


Trp Thr Met Arg Leu Asp Leu Arg Asp Leu Gln Arg His Leu Arg Phe 
            340                 345                 350         


Gln Val Glu Tyr Pro Pro Thr Cys Ser Thr Pro Arg Asp Gln His Thr 
        355                 360                 365             


Lys Leu Lys Leu Ile Gly Ser Leu Leu Lys Thr Ser Pro Ala Gln Arg 
    370                 375                 380                 


Leu Gly Lys Phe Gly Gly Arg Cys Ser Arg Ser Ser Val Cys Val Cys 
385                 390                 395                 400 


Val Cys Val Cys Val Cys Val Cys Val Cys Pro Arg Pro Arg Leu Cys 
                405                 410                 415     


Ser Leu Asn Leu Cys Leu Pro Met Glu Ser Trp Ser Glu Gln Leu Ala 
            420                 425                 430         


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
        435                 440                 445             


Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Phe Pro Arg Pro 
    450                 455                 460                 


Pro Gly Arg Ser Pro Leu Ser Leu Gln Glu Leu Arg Arg Glu Phe Lys 
465                 470                 475                 480 


Val Ser Leu Gln Leu Ala Lys Lys Leu Phe Ser Glu Val Arg Ile Gln 
                485                 490                 495     


Ala His His Phe Ala Glu Ser Gln Leu Pro Gly Val Ser Leu Asp Leu 
            500                 505                 510         


Leu Pro Leu Gly Asp Gln Leu Pro Asn Val Ser Leu Pro Phe Gln Ala 
        515                 520                 525             


Trp His Ser Leu Ser Asp Pro Glu Arg Leu Cys Phe Leu Ser Met Met 
    530                 535                 540                 


Leu His Pro Phe His Ala Leu Leu Glu Ser Leu Gly Ser Gln Gly Gly 
545                 550                 555                 560 


Trp Thr Ser Ser Glu Lys Met His Leu Trp Thr Met Arg Leu Asp Leu 
                565                 570                 575     


Arg Asp Leu Gln Arg His Leu Arg Phe Gln Val Glu Tyr Pro Pro Thr 
            580                 585                 590         


Cys Ser Thr Pro Arg Asp Gln His Thr Lys Leu Lys Leu Ile Gly Ser 
        595                 600                 605             


Leu Leu Lys Thr Ser Pro Ala Gln Arg Leu Gly Lys Phe Gly Gly Arg 
    610                 615                 620                 


Cys Ser Arg Ser Ser Val Cys Val Cys Val Cys Val Cys Val Cys Val 
625                 630                 635                 640 


Cys Val Cys Pro Arg Pro Arg Leu Cys Ser Leu Asn Leu Cys Leu Pro 
                645                 650                 655     


Met Glu Ser Trp Ser Glu Gln Leu Ala Gly Ser Gly Phe Asn Asn Phe 
            660                 665                 670         


Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu 
        675                 680                 685             


Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
    690                 695                 700                 


Ile Thr Glu Leu His His His His His His 
705                 710                 


<210>  300
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-27 polyprotein.

<400>  300

Phe Pro Arg Pro Pro Gly Arg Pro Pro Leu Ser Leu Gln Glu Leu Arg 
1               5                   10                  15      


Arg Glu Phe Lys Val Ser Leu His Leu Ala Arg Lys Leu Phe Ser Glu 
            20                  25                  30          


Val Arg Thr Gln Ala His Arg Phe Ala Glu Ser His Leu Pro Gly Val 
        35                  40                  45              


Ser Leu Asp Leu Leu Pro Leu Gly Asp Arg Leu Pro Asn Val Ser Leu 
    50                  55                  60                  


Thr Phe Gln Ala Trp His Ser Leu Ser Asp Pro Glu Arg Leu Cys Phe 
65                  70                  75                  80  


Leu Phe Met Thr Leu Arg Pro Phe His Ala Leu Leu Gly Ser Leu Gly 
                85                  90                  95      


Ser Gln Gly Gly Trp Thr Ser Ser Glu Lys Ile Asp Leu Trp Thr Met 
            100                 105                 110         


Arg Leu Asp Leu Arg Asp Leu Gln Arg His Leu His Phe Gln Val Leu 
        115                 120                 125             


Ala Ala Gly Leu Asn Leu Pro Glu Glu Glu Asp Asp Glu Glu Arg Lys 
    130                 135                 140                 


Glu Pro Leu Pro Gly Ala Pro Ser Gly Leu Ser Arg Val Ser Gly Gln 
145                 150                 155                 160 


Pro Ser Trp Pro Gln Leu Leu Tyr Thr Tyr Gln Leu Leu His Ser Leu 
                165                 170                 175     


Glu Leu Val Leu Ala Arg Ala Val Arg Asp Leu Leu Leu Leu Ser Gln 
            180                 185                 190         


Ala Gly Asn Pro Ala Pro Ala Ser Gly Ser Ser Phe Gly Ser Trp Pro 
        195                 200                 205             


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
    210                 215                 220                 


Thr Glu Leu Ala Gly Ser Gly Phe Pro Arg Pro Pro Gly Arg Pro Pro 
225                 230                 235                 240 


Leu Ser Leu Gln Glu Leu Arg Arg Glu Phe Lys Val Ser Leu His Leu 
                245                 250                 255     


Ala Arg Lys Leu Phe Ser Glu Val Arg Thr Gln Ala His Arg Phe Ala 
            260                 265                 270         


Glu Ser His Leu Pro Gly Val Ser Leu Asp Leu Leu Pro Leu Gly Asp 
        275                 280                 285             


Arg Leu Pro Asn Val Ser Leu Thr Phe Gln Ala Trp His Ser Leu Ser 
    290                 295                 300                 


Asp Pro Glu Arg Leu Cys Phe Leu Phe Met Thr Leu Arg Pro Phe His 
305                 310                 315                 320 


Ala Leu Leu Gly Ser Leu Gly Ser Gln Gly Gly Trp Thr Ser Ser Glu 
                325                 330                 335     


Lys Ile Asp Leu Trp Thr Met Arg Leu Asp Leu Arg Asp Leu Gln Arg 
            340                 345                 350         


His Leu His Phe Gln Val Leu Ala Ala Gly Leu Asn Leu Pro Glu Glu 
        355                 360                 365             


Glu Asp Asp Glu Glu Arg Lys Glu Pro Leu Pro Gly Ala Pro Ser Gly 
    370                 375                 380                 


Leu Ser Arg Val Ser Gly Gln Pro Ser Trp Pro Gln Leu Leu Tyr Thr 
385                 390                 395                 400 


Tyr Gln Leu Leu His Ser Leu Glu Leu Val Leu Ala Arg Ala Val Arg 
                405                 410                 415     


Asp Leu Leu Leu Leu Ser Gln Ala Gly Asn Pro Ala Pro Ala Ser Gly 
            420                 425                 430         


Ser Ser Phe Gly Ser Trp Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr 
        435                 440                 445             


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
    450                 455                 460                 


Ser Gly Gly Ser Phe Pro Arg Pro Pro Gly Arg Pro Pro Leu Ser Leu 
465                 470                 475                 480 


Gln Glu Leu Arg Arg Glu Phe Lys Val Ser Leu His Leu Ala Arg Lys 
                485                 490                 495     


Leu Phe Ser Glu Val Arg Thr Gln Ala His Arg Phe Ala Glu Ser His 
            500                 505                 510         


Leu Pro Gly Val Ser Leu Asp Leu Leu Pro Leu Gly Asp Arg Leu Pro 
        515                 520                 525             


Asn Val Ser Leu Thr Phe Gln Ala Trp His Ser Leu Ser Asp Pro Glu 
    530                 535                 540                 


Arg Leu Cys Phe Leu Phe Met Thr Leu Arg Pro Phe His Ala Leu Leu 
545                 550                 555                 560 


Gly Ser Leu Gly Ser Gln Gly Gly Trp Thr Ser Ser Glu Lys Ile Asp 
                565                 570                 575     


Leu Trp Thr Met Arg Leu Asp Leu Arg Asp Leu Gln Arg His Leu His 
            580                 585                 590         


Phe Gln Val Leu Ala Ala Gly Leu Asn Leu Pro Glu Glu Glu Asp Asp 
        595                 600                 605             


Glu Glu Arg Lys Glu Pro Leu Pro Gly Ala Pro Ser Gly Leu Ser Arg 
    610                 615                 620                 


Val Ser Gly Gln Pro Ser Trp Pro Gln Leu Leu Tyr Thr Tyr Gln Leu 
625                 630                 635                 640 


Leu His Ser Leu Glu Leu Val Leu Ala Arg Ala Val Arg Asp Leu Leu 
                645                 650                 655     


Leu Leu Ser Gln Ala Gly Asn Pro Ala Pro Ala Ser Gly Ser Ser Phe 
            660                 665                 670         


Gly Ser Trp Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
        675                 680                 685             


Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly 
    690                 695                 700                 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
705                 710                 715                 720 


His His His His His His 
                725     


<210>  301
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-29 polyprotein.

<400>  301

Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Arg Arg Gly Cys His 
1               5                   10                  15      


Met Asp Arg Phe Gln Ser Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys 
            20                  25                  30          


Lys Thr Lys Asp Ala Leu Glu Glu Ser Leu Ser Trp Lys Asn Trp Ser 
        35                  40                  45              


Cys Ser Ser Arg Leu Phe Pro Arg Ser Arg Asp Leu Arg Leu Leu Gln 
    50                  55                  60                  


Ala Trp Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Asp Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Glu Asn Met Thr Asp Ser Ser Leu Gly Val Thr Leu Asp 
                85                  90                  95      


Gln Pro Leu Arg Thr Leu His His Ile His Ser Glu Leu Gln Ala Cys 
            100                 105                 110         


Val Pro Ala Gln Pro Thr Ala Asp Pro Arg Pro His Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Lys Ala Pro Lys Glu Ser Gln Gly Cys 
    130                 135                 140                 


Leu Glu Ala Ser Ile Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp 
145                 150                 155                 160 


Leu Lys Cys Val Ala Ser Arg Asp Leu Cys Val Gly Ser Gly Gly Gln 
                165                 170                 175     


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly 
            180                 185                 190         


Ser Gly Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Arg Arg Gly 
        195                 200                 205             


Cys His Met Asp Arg Phe Gln Ser Leu Ser Pro Arg Glu Leu Glu Ala 
    210                 215                 220                 


Phe Lys Lys Thr Lys Asp Ala Leu Glu Glu Ser Leu Ser Trp Lys Asn 
225                 230                 235                 240 


Trp Ser Cys Ser Ser Arg Leu Phe Pro Arg Ser Arg Asp Leu Arg Leu 
                245                 250                 255     


Leu Gln Ala Trp Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Asp Leu 
            260                 265                 270         


Thr Leu Lys Val Leu Glu Asn Met Thr Asp Ser Ser Leu Gly Val Thr 
        275                 280                 285             


Leu Asp Gln Pro Leu Arg Thr Leu His His Ile His Ser Glu Leu Gln 
    290                 295                 300                 


Ala Cys Val Pro Ala Gln Pro Thr Ala Asp Pro Arg Pro His Gly Arg 
305                 310                 315                 320 


Leu His His Trp Leu His Arg Leu Gln Lys Ala Pro Lys Glu Ser Gln 
                325                 330                 335     


Gly Cys Leu Glu Ala Ser Ile Thr Phe Asn Leu Phe Arg Leu Leu Thr 
            340                 345                 350         


Arg Asp Leu Lys Cys Val Ala Ser Arg Asp Leu Cys Val Ala Gly Ser 
        355                 360                 365             


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
    370                 375                 380                 


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Gly Pro Val Pro Thr Ser 
385                 390                 395                 400 


Lys Pro Thr Thr Thr Arg Arg Gly Cys His Met Asp Arg Phe Gln Ser 
                405                 410                 415     


Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys Lys Thr Lys Asp Ala Leu 
            420                 425                 430         


Glu Glu Ser Leu Ser Trp Lys Asn Trp Ser Cys Ser Ser Arg Leu Phe 
        435                 440                 445             


Pro Arg Ser Arg Asp Leu Arg Leu Leu Gln Ala Trp Glu Arg Pro Val 
    450                 455                 460                 


Ala Leu Glu Ala Glu Leu Asp Leu Thr Leu Lys Val Leu Glu Asn Met 
465                 470                 475                 480 


Thr Asp Ser Ser Leu Gly Val Thr Leu Asp Gln Pro Leu Arg Thr Leu 
                485                 490                 495     


His His Ile His Ser Glu Leu Gln Ala Cys Val Pro Ala Gln Pro Thr 
            500                 505                 510         


Ala Asp Pro Arg Pro His Gly Arg Leu His His Trp Leu His Arg Leu 
        515                 520                 525             


Gln Lys Ala Pro Lys Glu Ser Gln Gly Cys Leu Glu Ala Ser Ile Thr 
    530                 535                 540                 


Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Cys Val Ala Ser 
545                 550                 555                 560 


Arg Asp Leu Cys Val Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
                565                 570                 575     


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser 
            580                 585                 590         


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
        595                 600                 605             


Leu His His His His His His 
    610                 615 


<210>  302
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of dog IL-29 // IFN-lambda1 
       polyprotein.

<400>  302

Gly Pro Val Pro Thr Ser Lys Pro Thr Met Ala Trp Arg Gly Cys Asp 
1               5                   10                  15      


Ile Gly Arg Phe Lys Ser Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys 
            20                  25                  30          


Lys Ala Lys Asp Ala Leu Glu Tyr Ser Leu Lys Asn Trp Ser Cys Asn 
        35                  40                  45              


Ser Arg Leu Phe Pro Arg Asn Arg Asp Leu Arg Gln Leu Gln Val Trp 
    50                  55                  60                  


Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val 
65                  70                  75                  80  


Leu Glu Thr Met Ala Asp Arg Ser Leu Gly Asp Ile Leu Asp Gln Pro 
                85                  90                  95      


Leu His Thr Leu Arg His Ile His Ser Gln Leu Gln Ala Cys Val Ser 
            100                 105                 110         


Ala Gln Pro Pro Ala Gly Pro Gln Pro Arg Gly Arg Leu His Pro Trp 
        115                 120                 125             


Leu His Arg Leu His Glu Ala Ser Lys Lys Glu Ser Gln Gly Cys Leu 
    130                 135                 140                 


Glu Ala Ser Val Leu Phe Asn Leu Phe Arg Leu Leu Lys Lys Asp Leu 
145                 150                 155                 160 


Glu Cys Val Ala Val Gly Asp Leu Cys Val Gly Ser Gly Gly Gln Tyr 
                165                 170                 175     


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser 
            180                 185                 190         


Gly Gly Pro Val Pro Thr Ser Lys Pro Thr Met Ala Trp Arg Gly Cys 
        195                 200                 205             


Asp Ile Gly Arg Phe Lys Ser Leu Ser Pro Arg Glu Leu Glu Ala Phe 
    210                 215                 220                 


Lys Lys Ala Lys Asp Ala Leu Glu Tyr Ser Leu Lys Asn Trp Ser Cys 
225                 230                 235                 240 


Asn Ser Arg Leu Phe Pro Arg Asn Arg Asp Leu Arg Gln Leu Gln Val 
                245                 250                 255     


Trp Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys 
            260                 265                 270         


Val Leu Glu Thr Met Ala Asp Arg Ser Leu Gly Asp Ile Leu Asp Gln 
        275                 280                 285             


Pro Leu His Thr Leu Arg His Ile His Ser Gln Leu Gln Ala Cys Val 
    290                 295                 300                 


Ser Ala Gln Pro Pro Ala Gly Pro Gln Pro Arg Gly Arg Leu His Pro 
305                 310                 315                 320 


Trp Leu His Arg Leu His Glu Ala Ser Lys Lys Glu Ser Gln Gly Cys 
                325                 330                 335     


Leu Glu Ala Ser Val Leu Phe Asn Leu Phe Arg Leu Leu Lys Lys Asp 
            340                 345                 350         


Leu Glu Cys Val Ala Val Gly Asp Leu Cys Val Ala Gly Ser Gly Phe 
        355                 360                 365             


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
    370                 375                 380                 


Ser His Leu Glu Ser Gly Gly Ser Gly Pro Val Pro Thr Ser Lys Pro 
385                 390                 395                 400 


Thr Met Ala Trp Arg Gly Cys Asp Ile Gly Arg Phe Lys Ser Leu Ser 
                405                 410                 415     


Pro Arg Glu Leu Glu Ala Phe Lys Lys Ala Lys Asp Ala Leu Glu Tyr 
            420                 425                 430         


Ser Leu Lys Asn Trp Ser Cys Asn Ser Arg Leu Phe Pro Arg Asn Arg 
        435                 440                 445             


Asp Leu Arg Gln Leu Gln Val Trp Glu Arg Pro Val Ala Leu Glu Ala 
    450                 455                 460                 


Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Thr Met Ala Asp Arg Ser 
465                 470                 475                 480 


Leu Gly Asp Ile Leu Asp Gln Pro Leu His Thr Leu Arg His Ile His 
                485                 490                 495     


Ser Gln Leu Gln Ala Cys Val Ser Ala Gln Pro Pro Ala Gly Pro Gln 
            500                 505                 510         


Pro Arg Gly Arg Leu His Pro Trp Leu His Arg Leu His Glu Ala Ser 
        515                 520                 525             


Lys Lys Glu Ser Gln Gly Cys Leu Glu Ala Ser Val Leu Phe Asn Leu 
    530                 535                 540                 


Phe Arg Leu Leu Lys Lys Asp Leu Glu Cys Val Ala Val Gly Asp Leu 
545                 550                 555                 560 


Cys Val Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu 
                565                 570                 575     


Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln 
            580                 585                 590         


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His 
        595                 600                 605             


His His His His 
    610         


<210>  303
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-29 polyprotein.

<400>  303

Gly Pro Val Pro Thr Ser Arg Pro Pro Pro Thr Arg Arg Gly Cys His 
1               5                   10                  15      


Val Gly Lys Phe Pro Ser Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys 
            20                  25                  30          


Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Pro Leu Lys Asn Trp Ser 
        35                  40                  45              


Cys Gly Ser Arg Leu Phe Pro Arg Thr Arg Asp Leu Ile Arg Leu Gln 
    50                  55                  60                  


Ala Trp Glu Arg Pro Ala Ala Leu Glu Ala Glu Leu Asp Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Gly Asn Met Thr Asp Ser Ser Leu Gly Val Val Leu Asp 
                85                  90                  95      


Gln Pro Leu Arg Val Val Arg His Ile His Ser Glu Leu Gln Ala Cys 
            100                 105                 110         


Val Arg Ala Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Arg Pro Pro Glu Glu Ser Gln Gly Cys 
    130                 135                 140                 


Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp 
145                 150                 155                 160 


Leu Lys Cys Val Thr Gly Gly Asp Leu Cys Val Gly Ser Gly Gly Gln 
                165                 170                 175     


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly 
            180                 185                 190         


Ser Gly Gly Pro Val Pro Thr Ser Arg Pro Pro Pro Thr Arg Arg Gly 
        195                 200                 205             


Cys His Val Gly Lys Phe Pro Ser Leu Ser Pro Arg Glu Leu Glu Ala 
    210                 215                 220                 


Phe Lys Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Pro Leu Lys Asn 
225                 230                 235                 240 


Trp Ser Cys Gly Ser Arg Leu Phe Pro Arg Thr Arg Asp Leu Ile Arg 
                245                 250                 255     


Leu Gln Ala Trp Glu Arg Pro Ala Ala Leu Glu Ala Glu Leu Asp Leu 
            260                 265                 270         


Thr Leu Lys Val Leu Gly Asn Met Thr Asp Ser Ser Leu Gly Val Val 
        275                 280                 285             


Leu Asp Gln Pro Leu Arg Val Val Arg His Ile His Ser Glu Leu Gln 
    290                 295                 300                 


Ala Cys Val Arg Ala Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg 
305                 310                 315                 320 


Leu His His Trp Leu His Arg Leu Gln Arg Pro Pro Glu Glu Ser Gln 
                325                 330                 335     


Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr 
            340                 345                 350         


Arg Asp Leu Lys Cys Val Thr Gly Gly Asp Leu Cys Val Ala Gly Ser 
        355                 360                 365             


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
    370                 375                 380                 


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Gly Pro Val Pro Thr Ser 
385                 390                 395                 400 


Arg Pro Pro Pro Thr Arg Arg Gly Cys His Val Gly Lys Phe Pro Ser 
                405                 410                 415     


Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys Lys Ala Arg Asp Ala Leu 
            420                 425                 430         


Glu Glu Ser Leu Pro Leu Lys Asn Trp Ser Cys Gly Ser Arg Leu Phe 
        435                 440                 445             


Pro Arg Thr Arg Asp Leu Ile Arg Leu Gln Ala Trp Glu Arg Pro Ala 
    450                 455                 460                 


Ala Leu Glu Ala Glu Leu Asp Leu Thr Leu Lys Val Leu Gly Asn Met 
465                 470                 475                 480 


Thr Asp Ser Ser Leu Gly Val Val Leu Asp Gln Pro Leu Arg Val Val 
                485                 490                 495     


Arg His Ile His Ser Glu Leu Gln Ala Cys Val Arg Ala Gln Pro Thr 
            500                 505                 510         


Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu 
        515                 520                 525             


Gln Arg Pro Pro Glu Glu Ser Gln Gly Cys Leu Glu Ala Ser Val Thr 
    530                 535                 540                 


Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Cys Val Thr Gly 
545                 550                 555                 560 


Gly Asp Leu Cys Val Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
                565                 570                 575     


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser 
            580                 585                 590         


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
        595                 600                 605             


Leu His His His His His His 
    610                 615 


<210>  304
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-29 // IFN-lambda1 
       polyprotein.

<400>  304

Gly Pro Val Pro Thr Ser Arg Pro Pro Pro Thr Arg Arg Gly Cys His 
1               5                   10                  15      


Val Gly Lys Phe Pro Ser Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys 
            20                  25                  30          


Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Pro Leu Lys Asn Trp Ser 
        35                  40                  45              


Cys Gly Ser Arg Leu Phe Pro Arg Thr Arg Asp Leu Ile Arg Leu Gln 
    50                  55                  60                  


Ala Trp Glu Arg Pro Ala Ala Leu Glu Ala Glu Leu Asp Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Gly Asn Met Thr Asp Ser Ser Leu Gly Val Val Leu Asp 
                85                  90                  95      


Gln Pro Leu Arg Val Leu Arg His Ile His Ser Glu Leu Gln Ala Cys 
            100                 105                 110         


Val Arg Ala Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Arg Ala Pro Glu Glu Ser Gln Gly Cys 
    130                 135                 140                 


Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp 
145                 150                 155                 160 


Leu Lys Cys Val Thr Gly Gly Asp Leu Cys Val Gly Ser Gly Gly Gln 
                165                 170                 175     


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly 
            180                 185                 190         


Ser Gly Gly Pro Val Pro Thr Ser Arg Pro Pro Pro Thr Arg Arg Gly 
        195                 200                 205             


Cys His Val Gly Lys Phe Pro Ser Leu Ser Pro Arg Glu Leu Glu Ala 
    210                 215                 220                 


Phe Lys Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Pro Leu Lys Asn 
225                 230                 235                 240 


Trp Ser Cys Gly Ser Arg Leu Phe Pro Arg Thr Arg Asp Leu Ile Arg 
                245                 250                 255     


Leu Gln Ala Trp Glu Arg Pro Ala Ala Leu Glu Ala Glu Leu Asp Leu 
            260                 265                 270         


Thr Leu Lys Val Leu Gly Asn Met Thr Asp Ser Ser Leu Gly Val Val 
        275                 280                 285             


Leu Asp Gln Pro Leu Arg Val Leu Arg His Ile His Ser Glu Leu Gln 
    290                 295                 300                 


Ala Cys Val Arg Ala Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg 
305                 310                 315                 320 


Leu His His Trp Leu His Arg Leu Gln Arg Ala Pro Glu Glu Ser Gln 
                325                 330                 335     


Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr 
            340                 345                 350         


Arg Asp Leu Lys Cys Val Thr Gly Gly Asp Leu Cys Val Ala Gly Ser 
        355                 360                 365             


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
    370                 375                 380                 


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Gly Pro Val Pro Thr Ser 
385                 390                 395                 400 


Arg Pro Pro Pro Thr Arg Arg Gly Cys His Val Gly Lys Phe Pro Ser 
                405                 410                 415     


Leu Ser Pro Arg Glu Leu Glu Ala Phe Lys Lys Ala Arg Asp Ala Leu 
            420                 425                 430         


Glu Glu Ser Leu Pro Leu Lys Asn Trp Ser Cys Gly Ser Arg Leu Phe 
        435                 440                 445             


Pro Arg Thr Arg Asp Leu Ile Arg Leu Gln Ala Trp Glu Arg Pro Ala 
    450                 455                 460                 


Ala Leu Glu Ala Glu Leu Asp Leu Thr Leu Lys Val Leu Gly Asn Met 
465                 470                 475                 480 


Thr Asp Ser Ser Leu Gly Val Val Leu Asp Gln Pro Leu Arg Val Leu 
                485                 490                 495     


Arg His Ile His Ser Glu Leu Gln Ala Cys Val Arg Ala Gln Pro Thr 
            500                 505                 510         


Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu 
        515                 520                 525             


Gln Arg Ala Pro Glu Glu Ser Gln Gly Cys Leu Glu Ala Ser Val Thr 
    530                 535                 540                 


Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Cys Val Thr Gly 
545                 550                 555                 560 


Gly Asp Leu Cys Val Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
                565                 570                 575     


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser 
            580                 585                 590         


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
        595                 600                 605             


Leu His His His His His His 
    610                 615 


<210>  305
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-29 // IFN-lambda1 
       polyprotein.

<400>  305

Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys Gly Cys His 
1               5                   10                  15      


Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys 
            20                  25                  30          


Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser 
        35                  40                  45              


Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln 
    50                  55                  60                  


Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp 
                85                  90                  95      


Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Cys 
            100                 105                 110         


Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly 
    130                 135                 140                 


Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg 
145                 150                 155                 160 


Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg Thr Ser Thr 
                165                 170                 175     


His Pro Glu Ser Thr Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
            180                 185                 190         


Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Gly Pro Val Pro 
        195                 200                 205             


Thr Ser Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe 
    210                 215                 220                 


Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp 
225                 230                 235                 240 


Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro 
                245                 250                 255     


Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg 
            260                 265                 270         


Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu 
        275                 280                 285             


Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His 
    290                 295                 300                 


Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln 
305                 310                 315                 320 


Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His 
                325                 330                 335     


Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala 
            340                 345                 350         


Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Tyr 
        355                 360                 365             


Val Ala Asp Gly Asn Leu Cys Leu Arg Thr Ser Thr His Pro Glu Ser 
    370                 375                 380                 


Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
385                 390                 395                 400 


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Gly Pro 
                405                 410                 415     


Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly 
            420                 425                 430         


Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala 
        435                 440                 445             


Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser 
    450                 455                 460                 


Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg 
465                 470                 475                 480 


Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val 
                485                 490                 495     


Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro 
            500                 505                 510         


Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln 
        515                 520                 525             


Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp 
    530                 535                 540                 


Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu 
545                 550                 555                 560 


Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu 
                565                 570                 575     


Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg Thr Ser Thr His Pro 
            580                 585                 590         


Glu Ser Thr Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
        595                 600                 605             


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly 
    610                 615                 620                 


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His 
625                 630                 635                 640 


His His His His His 
                645 


<210>  306
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of cat IL-32 polyprotein.

<400>  306

Met Arg His Gln Met His Gln Leu Val Asp Ile Phe Cys Asp Arg Thr 
1               5                   10                  15      


Gln His Gln Ser Arg Gly Ala Pro Gln Gln Arg Leu Arg Leu Gly Glu 
            20                  25                  30          


Val Glu Asp Gly Phe Asn Glu Ile Met Leu Glu Ala Val Asp Leu His 
        35                  40                  45              


His His Gln Asn Asp Asp Glu Glu Ser Ser Pro Leu Leu Pro Glu Val 
    50                  55                  60                  


Arg Gln Glu Leu Arg Ser Arg Val Leu Arg Ser Ser Val Leu Asp Leu 
65                  70                  75                  80  


Glu Glu Lys Glu His Pro Val Val Gln Lys Thr Glu Glu Ser Phe Cys 
                85                  90                  95      


Asp Arg Ala Leu Arg Leu Phe Arg Arg Leu Leu Tyr Gln Leu Gln Leu 
            100                 105                 110         


Lys Trp Gln Ala Ala Leu Ala Trp Leu Arg Glu Lys Val Ala Ala Gly 
        115                 120                 125             


Phe Gln Ala Phe Cys Asp Ala Val Glu Ala Ile Cys Ser Ala Phe Asn 
    130                 135                 140                 


Ser Phe Cys Thr Ser Val Ala Gln Val Phe Arg Ser Ala Val Gln Ala 
145                 150                 155                 160 


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
                165                 170                 175     


Thr Glu Leu Ala Gly Ser Gly Met Arg His Gln Met His Gln Leu Val 
            180                 185                 190         


Asp Ile Phe Cys Asp Arg Thr Gln His Gln Ser Arg Gly Ala Pro Gln 
        195                 200                 205             


Gln Arg Leu Arg Leu Gly Glu Val Glu Asp Gly Phe Asn Glu Ile Met 
    210                 215                 220                 


Leu Glu Ala Val Asp Leu His His His Gln Asn Asp Asp Glu Glu Ser 
225                 230                 235                 240 


Ser Pro Leu Leu Pro Glu Val Arg Gln Glu Leu Arg Ser Arg Val Leu 
                245                 250                 255     


Arg Ser Ser Val Leu Asp Leu Glu Glu Lys Glu His Pro Val Val Gln 
            260                 265                 270         


Lys Thr Glu Glu Ser Phe Cys Asp Arg Ala Leu Arg Leu Phe Arg Arg 
        275                 280                 285             


Leu Leu Tyr Gln Leu Gln Leu Lys Trp Gln Ala Ala Leu Ala Trp Leu 
    290                 295                 300                 


Arg Glu Lys Val Ala Ala Gly Phe Gln Ala Phe Cys Asp Ala Val Glu 
305                 310                 315                 320 


Ala Ile Cys Ser Ala Phe Asn Ser Phe Cys Thr Ser Val Ala Gln Val 
                325                 330                 335     


Phe Arg Ser Ala Val Gln Ala Ala Gly Ser Gly Phe Asn Asn Phe Thr 
            340                 345                 350         


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
        355                 360                 365             


Ser Gly Gly Ser Met Arg His Gln Met His Gln Leu Val Asp Ile Phe 
    370                 375                 380                 


Cys Asp Arg Thr Gln His Gln Ser Arg Gly Ala Pro Gln Gln Arg Leu 
385                 390                 395                 400 


Arg Leu Gly Glu Val Glu Asp Gly Phe Asn Glu Ile Met Leu Glu Ala 
                405                 410                 415     


Val Asp Leu His His His Gln Asn Asp Asp Glu Glu Ser Ser Pro Leu 
            420                 425                 430         


Leu Pro Glu Val Arg Gln Glu Leu Arg Ser Arg Val Leu Arg Ser Ser 
        435                 440                 445             


Val Leu Asp Leu Glu Glu Lys Glu His Pro Val Val Gln Lys Thr Glu 
    450                 455                 460                 


Glu Ser Phe Cys Asp Arg Ala Leu Arg Leu Phe Arg Arg Leu Leu Tyr 
465                 470                 475                 480 


Gln Leu Gln Leu Lys Trp Gln Ala Ala Leu Ala Trp Leu Arg Glu Lys 
                485                 490                 495     


Val Ala Ala Gly Phe Gln Ala Phe Cys Asp Ala Val Glu Ala Ile Cys 
            500                 505                 510         


Ser Ala Phe Asn Ser Phe Cys Thr Ser Val Ala Gln Val Phe Arg Ser 
        515                 520                 525             


Ala Val Gln Ala Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
    530                 535                 540                 


Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly 
545                 550                 555                 560 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                565                 570                 575     


His His His His His His 
            580         


<210>  307
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine IL-34 polyprotein.

<400>  307

Asn Glu Gly Leu Glu Pro Trp Pro Leu Thr Arg Ser Asp Glu Cys Ala 
1               5                   10                  15      


Ile Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln 
            20                  25                  30          


Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Val Ser Val Pro Tyr 
        35                  40                  45              


Glu Gly Val Leu Arg Thr Ala Asn Val Thr Arg Leu Gln Arg Ala Gln 
    50                  55                  60                  


Val Ser Gln Gln Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser 
65                  70                  75                  80  


Ala Thr Glu Trp Val Gln Glu Val Leu Leu Glu Gly His Pro Ser Trp 
                85                  90                  95      


Lys Tyr Leu Glu Glu Val His Thr Leu Leu Leu Asp Val Lys Gln Gly 
            100                 105                 110         


Leu Gly Gly Val Glu Val Ser Pro Gln Val Glu Ala Val Leu Asn Leu 
        115                 120                 125             


Leu Ser Ala Pro Gly Ser Leu Lys Leu Val Arg Pro Lys Ala Leu Leu 
    130                 135                 140                 


Asp Asn Cys Phe Arg Val Met Gln Leu Leu Tyr Cys Pro Cys Cys Lys 
145                 150                 155                 160 


Glu Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Ala Pro Gln Pro Gln 
                165                 170                 175     


Pro Arg Ser Pro Ala Ser Ala Gln Cys Glu Ala Ala Gln Leu Tyr Pro 
            180                 185                 190         


Leu Pro Gln Pro Pro Ser Thr Ser Leu Pro Arg Val Leu Gly Pro Ser 
        195                 200                 205             


Ala Gly Pro Pro Thr Gln Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
    210                 215                 220                 


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Asn Glu Gly 
225                 230                 235                 240 


Leu Glu Pro Trp Pro Leu Thr Arg Ser Asp Glu Cys Ala Ile Thr Gly 
                245                 250                 255     


Phe Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln Tyr Met Lys 
            260                 265                 270         


His Tyr Phe Pro Ile Asn Tyr Arg Val Ser Val Pro Tyr Glu Gly Val 
        275                 280                 285             


Leu Arg Thr Ala Asn Val Thr Arg Leu Gln Arg Ala Gln Val Ser Gln 
    290                 295                 300                 


Gln Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser Ala Thr Glu 
305                 310                 315                 320 


Trp Val Gln Glu Val Leu Leu Glu Gly His Pro Ser Trp Lys Tyr Leu 
                325                 330                 335     


Glu Glu Val His Thr Leu Leu Leu Asp Val Lys Gln Gly Leu Gly Gly 
            340                 345                 350         


Val Glu Val Ser Pro Gln Val Glu Ala Val Leu Asn Leu Leu Ser Ala 
        355                 360                 365             


Pro Gly Ser Leu Lys Leu Val Arg Pro Lys Ala Leu Leu Asp Asn Cys 
    370                 375                 380                 


Phe Arg Val Met Gln Leu Leu Tyr Cys Pro Cys Cys Lys Glu Ser Ser 
385                 390                 395                 400 


Val Leu Asn Trp Gln Asp Cys Glu Ala Pro Gln Pro Gln Pro Arg Ser 
                405                 410                 415     


Pro Ala Ser Ala Gln Cys Glu Ala Ala Gln Leu Tyr Pro Leu Pro Gln 
            420                 425                 430         


Pro Pro Ser Thr Ser Leu Pro Arg Val Leu Gly Pro Ser Ala Gly Pro 
        435                 440                 445             


Pro Thr Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
    450                 455                 460                 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
465                 470                 475                 480 


Asn Glu Gly Leu Glu Pro Trp Pro Leu Thr Arg Ser Asp Glu Cys Ala 
                485                 490                 495     


Ile Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln 
            500                 505                 510         


Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Val Ser Val Pro Tyr 
        515                 520                 525             


Glu Gly Val Leu Arg Thr Ala Asn Val Thr Arg Leu Gln Arg Ala Gln 
    530                 535                 540                 


Val Ser Gln Gln Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser 
545                 550                 555                 560 


Ala Thr Glu Trp Val Gln Glu Val Leu Leu Glu Gly His Pro Ser Trp 
                565                 570                 575     


Lys Tyr Leu Glu Glu Val His Thr Leu Leu Leu Asp Val Lys Gln Gly 
            580                 585                 590         


Leu Gly Gly Val Glu Val Ser Pro Gln Val Glu Ala Val Leu Asn Leu 
        595                 600                 605             


Leu Ser Ala Pro Gly Ser Leu Lys Leu Val Arg Pro Lys Ala Leu Leu 
    610                 615                 620                 


Asp Asn Cys Phe Arg Val Met Gln Leu Leu Tyr Cys Pro Cys Cys Lys 
625                 630                 635                 640 


Glu Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Ala Pro Gln Pro Gln 
                645                 650                 655     


Pro Arg Ser Pro Ala Ser Ala Gln Cys Glu Ala Ala Gln Leu Tyr Pro 
            660                 665                 670         


Leu Pro Gln Pro Pro Ser Thr Ser Leu Pro Arg Val Leu Gly Pro Ser 
        675                 680                 685             


Ala Gly Pro Pro Thr Gln Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
    690                 695                 700                 


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
705                 710                 715                 720 


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
                725                 730                 735     


Glu Leu His His His His His His 
            740                 


<210>  308
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-36-alpha polyprotein.

<400>  308

Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln Asp Ile Asn His Arg 
1               5                   10                  15      


Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala Val Pro Arg Lys Asp 
            20                  25                  30          


Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser Cys Arg His Val Glu 
        35                  40                  45              


Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu Gly Leu Asn Gly 
    50                  55                  60                  


Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly Asp Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly Arg Asn Ser Thr 
            100                 105                 110         


Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala Val Ser Ser Glu 
        115                 120                 125             


Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Lys Ala Asn Thr 
    130                 135                 140                 


Thr Asp Phe Gly Leu Thr Met Leu Phe Gly Ser Gly Gly Gln Tyr Ile 
145                 150                 155                 160 


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly 
                165                 170                 175     


Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln Asp Ile Asn His Arg 
            180                 185                 190         


Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala Val Pro Arg Lys Asp 
        195                 200                 205             


Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser Cys Arg His Val Glu 
    210                 215                 220                 


Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu Gly Leu Asn Gly 
225                 230                 235                 240 


Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly Asp Gln Pro Thr Leu 
                245                 250                 255     


Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn Gln Pro Glu Pro 
            260                 265                 270         


Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly Arg Asn Ser Thr 
        275                 280                 285             


Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala Val Ser Ser Glu 
    290                 295                 300                 


Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Lys Ala Asn Thr 
305                 310                 315                 320 


Thr Asp Phe Gly Leu Thr Met Leu Phe Ala Gly Ser Gly Phe Asn Asn 
                325                 330                 335     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            340                 345                 350         


Leu Glu Ser Gly Gly Ser Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile 
        355                 360                 365             


Gln Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile 
    370                 375                 380                 


Ala Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile 
385                 390                 395                 400 


Ser Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile 
                405                 410                 415     


Tyr Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val 
            420                 425                 430         


Gly Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu 
        435                 440                 445             


Tyr Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln 
    450                 455                 460                 


Ser Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe 
465                 470                 475                 480 


Ile Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu 
                485                 490                 495     


Leu Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe Ala 
            500                 505                 510         


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
        515                 520                 525             


Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys 
    530                 535                 540                 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His 
545                 550                 555                 560 


His 
    


<210>  309
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-36-beta polyprotein.

<400>  309

Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp Ser Arg Gln Met 
1               5                   10                  15      


Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala Pro Leu Ser Arg 
            20                  25                  30          


Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys Arg Asp Thr Glu 
        35                  40                  45              


Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu Gly Ile Lys Gly 
    50                  55                  60                  


Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly Lys Asp Thr Cys 
                85                  90                  95      


Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu Asp Val Arg Glu 
            100                 105                 110         


Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile Gly Val Gly Arg 
        115                 120                 125             


Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu Arg Lys Lys Asp 
    130                 135                 140                 


Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met Pro Gly Arg Met 
145                 150                 155                 160 


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
                165                 170                 175     


Thr Glu Leu Ala Gly Ser Gly Arg Glu Ala Ala Pro Lys Ser Tyr Ala 
            180                 185                 190         


Ile Arg Asp Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu 
        195                 200                 205             


Ile Ala Ala Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu 
    210                 215                 220                 


Ile Ala Cys Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met 
225                 230                 235                 240 


Val Tyr Leu Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu 
                245                 250                 255     


Ile Gln Gly Lys Pro Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp 
            260                 265                 270         


Asn Ile Gly Lys Asp Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys 
        275                 280                 285             


Ile Asn Leu Asp Val Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln 
    290                 295                 300                 


Trp Gly Ile Gly Val Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His 
305                 310                 315                 320 


His His Leu Arg Lys Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn 
                325                 330                 335     


Ile Gly Met Pro Gly Arg Met Ala Gly Ser Gly Phe Asn Asn Phe Thr 
            340                 345                 350         


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
        355                 360                 365             


Ser Gly Gly Ser Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp 
    370                 375                 380                 


Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala 
385                 390                 395                 400 


Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys 
                405                 410                 415     


Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu 
            420                 425                 430         


Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly 
        435                 440                 445             


Lys Pro Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly 
    450                 455                 460                 


Lys Asp Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu 
465                 470                 475                 480 


Asp Val Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile 
                485                 490                 495     


Gly Val Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu 
            500                 505                 510         


Arg Lys Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met 
        515                 520                 525             


Pro Gly Arg Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
    530                 535                 540                 


Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly 
545                 550                 555                 560 


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
                565                 570                 575     


His His His His His His 
            580         


<210>  310
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-36-gamma polyprotein.

<400>  310

Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln Gln 
1               5                   10                  15      


Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser Asp 
            20                  25                  30          


Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro Glu 
        35                  40                  45              


Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln Asn 
    50                  55                  60                  


Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser Thr 
            100                 105                 110         


Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys Arg 
        115                 120                 125             


Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn Thr 
    130                 135                 140                 


Ala Phe Glu Leu Asn Ile Asn Asp Gly Ser Gly Gly Gln Tyr Ile Lys 
145                 150                 155                 160 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Ser 
                165                 170                 175     


Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln Gln Val 
            180                 185                 190         


Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser Asp Ser 
        195                 200                 205             


Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro Glu Ala 
    210                 215                 220                 


Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln Asn Pro 
225                 230                 235                 240 


Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr Leu Gln 
                245                 250                 255     


Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu Pro Val 
            260                 265                 270         


Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser Thr Leu 
        275                 280                 285             


Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys Arg Asp 
    290                 295                 300                 


Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn Thr Ala 
305                 310                 315                 320 


Phe Glu Leu Asn Ile Asn Asp Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                325                 330                 335     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            340                 345                 350         


Ser Gly Gly Ser Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp 
        355                 360                 365             


Leu Asn Gln Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val 
    370                 375                 380                 


Pro Arg Ser Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys 
385                 390                 395                 400 


Lys Tyr Pro Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu 
                405                 410                 415     


Gly Ile Gln Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu 
            420                 425                 430         


Gln Pro Thr Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly 
        435                 440                 445             


Gln Pro Glu Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly 
    450                 455                 460                 


Arg Thr Ser Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala 
465                 470                 475                 480 


Ser Ser Lys Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys 
                485                 490                 495     


Ser Tyr Asn Thr Ala Phe Glu Leu Asn Ile Asn Asp Ala Gly Ser Gly 
            500                 505                 510         


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
        515                 520                 525             


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    530                 535                 540                 


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
545                 550                 555             


<210>  311
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of canine IL-37 polyprotein.

<400>  311

Met Ser Phe Leu Glu Asp Ser Gly Val Lys Met Glu Ser Glu Asp Trp 
1               5                   10                  15      


Glu Arg Asp Glu Pro His Gly Cys Ser Glu Gly Pro Lys Val Lys Val 
            20                  25                  30          


Ser Tyr Pro Glu Lys Phe Ser Ile His Asp Arg Asp His Lys Val Leu 
        35                  40                  45              


Val Leu Asp Cys Asp Thr Leu Arg Ala Val Pro Phe Lys Thr Tyr Ile 
    50                  55                  60                  


Arg Pro Glu Met Phe Phe Val Leu Ala Ser Ser Leu Ser Ser Ala Ser 
65                  70                  75                  80  


Lys Glu Lys Gly Ser Pro Ile Leu Leu Ala Val Cys Lys Gly Glu Leu 
                85                  90                  95      


Cys Leu Cys Cys Glu Lys Asp Arg Arg Gln Ser Gln Pro Ser Leu Gln 
            100                 105                 110         


Leu Lys Lys Lys Lys Leu Thr Asn Leu Ala Ala Gln Lys Glu Ser Ala 
        115                 120                 125             


Arg Gln Pro Phe Ile Phe Tyr Arg Thr Lys Val Gly Ser Gln Asn Arg 
    130                 135                 140                 


Leu Glu Ser Ala Ala His Pro Gly Trp Phe Ile Cys Thr Ser Arg Asn 
145                 150                 155                 160 


Ser Gly Glu Pro Val Gly Val Thr Asn Val Leu Gly Lys Arg Lys His 
                165                 170                 175     


Thr Glu Phe Ser Phe His Arg Ala Glu Thr Ser Pro Ser Glu Val Ser 
            180                 185                 190         


Gly Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
        195                 200                 205             


Ile Thr Glu Leu Ala Gly Ser Gly Met Ser Phe Leu Glu Asp Ser Gly 
    210                 215                 220                 


Val Lys Met Glu Ser Glu Asp Trp Glu Arg Asp Glu Pro His Gly Cys 
225                 230                 235                 240 


Ser Glu Gly Pro Lys Val Lys Val Ser Tyr Pro Glu Lys Phe Ser Ile 
                245                 250                 255     


His Asp Arg Asp His Lys Val Leu Val Leu Asp Cys Asp Thr Leu Arg 
            260                 265                 270         


Ala Val Pro Phe Lys Thr Tyr Ile Arg Pro Glu Met Phe Phe Val Leu 
        275                 280                 285             


Ala Ser Ser Leu Ser Ser Ala Ser Lys Glu Lys Gly Ser Pro Ile Leu 
    290                 295                 300                 


Leu Ala Val Cys Lys Gly Glu Leu Cys Leu Cys Cys Glu Lys Asp Arg 
305                 310                 315                 320 


Arg Gln Ser Gln Pro Ser Leu Gln Leu Lys Lys Lys Lys Leu Thr Asn 
                325                 330                 335     


Leu Ala Ala Gln Lys Glu Ser Ala Arg Gln Pro Phe Ile Phe Tyr Arg 
            340                 345                 350         


Thr Lys Val Gly Ser Gln Asn Arg Leu Glu Ser Ala Ala His Pro Gly 
        355                 360                 365             


Trp Phe Ile Cys Thr Ser Arg Asn Ser Gly Glu Pro Val Gly Val Thr 
    370                 375                 380                 


Asn Val Leu Gly Lys Arg Lys His Thr Glu Phe Ser Phe His Arg Ala 
385                 390                 395                 400 


Glu Thr Ser Pro Ser Glu Val Ser Gly Ala Gly Ser Gly Phe Asn Asn 
                405                 410                 415     


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
            420                 425                 430         


Leu Glu Ser Gly Gly Ser Met Ser Phe Leu Glu Asp Ser Gly Val Lys 
        435                 440                 445             


Met Glu Ser Glu Asp Trp Glu Arg Asp Glu Pro His Gly Cys Ser Glu 
    450                 455                 460                 


Gly Pro Lys Val Lys Val Ser Tyr Pro Glu Lys Phe Ser Ile His Asp 
465                 470                 475                 480 


Arg Asp His Lys Val Leu Val Leu Asp Cys Asp Thr Leu Arg Ala Val 
                485                 490                 495     


Pro Phe Lys Thr Tyr Ile Arg Pro Glu Met Phe Phe Val Leu Ala Ser 
            500                 505                 510         


Ser Leu Ser Ser Ala Ser Lys Glu Lys Gly Ser Pro Ile Leu Leu Ala 
        515                 520                 525             


Val Cys Lys Gly Glu Leu Cys Leu Cys Cys Glu Lys Asp Arg Arg Gln 
    530                 535                 540                 


Ser Gln Pro Ser Leu Gln Leu Lys Lys Lys Lys Leu Thr Asn Leu Ala 
545                 550                 555                 560 


Ala Gln Lys Glu Ser Ala Arg Gln Pro Phe Ile Phe Tyr Arg Thr Lys 
                565                 570                 575     


Val Gly Ser Gln Asn Arg Leu Glu Ser Ala Ala His Pro Gly Trp Phe 
            580                 585                 590         


Ile Cys Thr Ser Arg Asn Ser Gly Glu Pro Val Gly Val Thr Asn Val 
        595                 600                 605             


Leu Gly Lys Arg Lys His Thr Glu Phe Ser Phe His Arg Ala Glu Thr 
    610                 615                 620                 


Ser Pro Ser Glu Val Ser Gly Ala Gly Ser Gly Phe Asn Asn Phe Thr 
625                 630                 635                 640 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
                645                 650                 655     


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
            660                 665                 670         


Thr Glu Leu His His His His His His 
        675                 680     


<210>  312
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-38 polyprotein.

<400>  312

Met Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp 
1               5                   10                  15      


Gln Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro 
            20                  25                  30          


Val Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile Leu Pro Asn Arg 
        35                  40                  45              


Gly Leu Ala Arg Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly 
    50                  55                  60                  


Ser Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln 
65                  70                  75                  80  


Leu Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala 
                85                  90                  95      


Thr Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu 
            100                 105                 110         


Glu Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro 
        115                 120                 125             


Gln Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Glu Gln Ser Trp Gly Ser Gly Gly Gln Tyr Ile Lys 
145                 150                 155                 160 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Met 
                165                 170                 175     


Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp Gln 
            180                 185                 190         


Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro Val 
        195                 200                 205             


Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile Leu Pro Asn Arg Gly 
    210                 215                 220                 


Leu Ala Arg Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly Ser 
225                 230                 235                 240 


Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln Leu 
                245                 250                 255     


Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala Thr 
            260                 265                 270         


Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu Glu 
        275                 280                 285             


Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro Gln 
    290                 295                 300                 


Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr Lys 
305                 310                 315                 320 


Phe Tyr Phe Glu Gln Ser Trp Ala Gly Ser Gly Phe Asn Asn Phe Thr 
                325                 330                 335     


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
            340                 345                 350         


Ser Gly Gly Ser Met Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile 
        355                 360                 365             


Lys Tyr Ala Asp Gln Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu 
    370                 375                 380                 


Val Gly Asp Pro Val Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile 
385                 390                 395                 400 


Leu Pro Asn Arg Gly Leu Ala Arg Thr Lys Val Pro Ile Phe Leu Gly 
                405                 410                 415     


Ile Gln Gly Gly Ser Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly 
            420                 425                 430         


Pro Ser Leu Gln Leu Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly 
        435                 440                 445             


Gly Glu Glu Ala Thr Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser 
    450                 455                 460                 


Ala Phe Arg Leu Glu Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly 
465                 470                 475                 480 


Pro Ala Glu Pro Gln Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro 
                485                 490                 495     


Ser Ala Arg Thr Lys Phe Tyr Phe Glu Gln Ser Trp Ala Gly Ser Gly 
            500                 505                 510         


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
        515                 520                 525             


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
    530                 535                 540                 


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
545                 550                 555             


<210>  313
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-40 polyprotein.

<400>  313

Arg Glu Glu Glu Ile Thr Pro Val Val Ser Ile Ala Tyr Lys Val Leu 
1               5                   10                  15      


Glu Val Phe Pro Lys Gly Arg Trp Val Leu Ile Thr Cys Cys Ala Pro 
            20                  25                  30          


Gln Pro Pro Pro Pro Ile Thr Tyr Ser Leu Cys Gly Thr Lys Asn Ile 
        35                  40                  45              


Lys Val Ala Lys Lys Val Val Lys Thr His Glu Pro Ala Ser Phe Asn 
    50                  55                  60                  


Leu Asn Val Thr Leu Lys Ser Ser Pro Asp Leu Leu Thr Tyr Phe Cys 
65                  70                  75                  80  


Trp Ala Ser Ser Thr Ser Gly Ala His Val Asp Ser Ala Arg Leu Gln 
                85                  90                  95      


Met His Trp Glu Leu Trp Ser Lys Pro Val Ser Glu Leu Arg Ala Asn 
            100                 105                 110         


Phe Thr Leu Gln Asp Arg Gly Ala Gly Pro Arg Val Glu Met Ile Cys 
        115                 120                 125             


Gln Ala Ser Ser Gly Ser Pro Pro Ile Thr Asn Ser Leu Ile Gly Lys 
    130                 135                 140                 


Asp Gly Gln Val His Leu Gln Gln Arg Pro Cys His Arg Gln Pro Ala 
145                 150                 155                 160 


Asn Phe Ser Phe Leu Pro Ser Gln Thr Ser Asp Trp Phe Trp Cys Gln 
                165                 170                 175     


Ala Ala Asn Asn Ala Asn Val Gln His Ser Ala Leu Thr Val Val Pro 
            180                 185                 190         


Pro Gly Gly Asp Gln Lys Met Glu Asp Trp Gln Gly Pro Leu Glu Ser 
        195                 200                 205             


Pro Ile Leu Ala Leu Pro Leu Tyr Arg Ser Thr Arg Arg Leu Ser Glu 
    210                 215                 220                 


Glu Glu Phe Gly Gly Phe Arg Ile Gly Asn Gly Glu Val Arg Gly Arg 
225                 230                 235                 240 


Lys Ala Ala Ala Met Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
                245                 250                 255     


Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Arg Glu Glu Glu 
            260                 265                 270         


Ile Thr Pro Val Val Ser Ile Ala Tyr Lys Val Leu Glu Val Phe Pro 
        275                 280                 285             


Lys Gly Arg Trp Val Leu Ile Thr Cys Cys Ala Pro Gln Pro Pro Pro 
    290                 295                 300                 


Pro Ile Thr Tyr Ser Leu Cys Gly Thr Lys Asn Ile Lys Val Ala Lys 
305                 310                 315                 320 


Lys Val Val Lys Thr His Glu Pro Ala Ser Phe Asn Leu Asn Val Thr 
                325                 330                 335     


Leu Lys Ser Ser Pro Asp Leu Leu Thr Tyr Phe Cys Trp Ala Ser Ser 
            340                 345                 350         


Thr Ser Gly Ala His Val Asp Ser Ala Arg Leu Gln Met His Trp Glu 
        355                 360                 365             


Leu Trp Ser Lys Pro Val Ser Glu Leu Arg Ala Asn Phe Thr Leu Gln 
    370                 375                 380                 


Asp Arg Gly Ala Gly Pro Arg Val Glu Met Ile Cys Gln Ala Ser Ser 
385                 390                 395                 400 


Gly Ser Pro Pro Ile Thr Asn Ser Leu Ile Gly Lys Asp Gly Gln Val 
                405                 410                 415     


His Leu Gln Gln Arg Pro Cys His Arg Gln Pro Ala Asn Phe Ser Phe 
            420                 425                 430         


Leu Pro Ser Gln Thr Ser Asp Trp Phe Trp Cys Gln Ala Ala Asn Asn 
        435                 440                 445             


Ala Asn Val Gln His Ser Ala Leu Thr Val Val Pro Pro Gly Gly Asp 
    450                 455                 460                 


Gln Lys Met Glu Asp Trp Gln Gly Pro Leu Glu Ser Pro Ile Leu Ala 
465                 470                 475                 480 


Leu Pro Leu Tyr Arg Ser Thr Arg Arg Leu Ser Glu Glu Glu Phe Gly 
                485                 490                 495     


Gly Phe Arg Ile Gly Asn Gly Glu Val Arg Gly Arg Lys Ala Ala Ala 
            500                 505                 510         


Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
        515                 520                 525             


Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Arg Glu 
    530                 535                 540                 


Glu Glu Ile Thr Pro Val Val Ser Ile Ala Tyr Lys Val Leu Glu Val 
545                 550                 555                 560 


Phe Pro Lys Gly Arg Trp Val Leu Ile Thr Cys Cys Ala Pro Gln Pro 
                565                 570                 575     


Pro Pro Pro Ile Thr Tyr Ser Leu Cys Gly Thr Lys Asn Ile Lys Val 
            580                 585                 590         


Ala Lys Lys Val Val Lys Thr His Glu Pro Ala Ser Phe Asn Leu Asn 
        595                 600                 605             


Val Thr Leu Lys Ser Ser Pro Asp Leu Leu Thr Tyr Phe Cys Trp Ala 
    610                 615                 620                 


Ser Ser Thr Ser Gly Ala His Val Asp Ser Ala Arg Leu Gln Met His 
625                 630                 635                 640 


Trp Glu Leu Trp Ser Lys Pro Val Ser Glu Leu Arg Ala Asn Phe Thr 
                645                 650                 655     


Leu Gln Asp Arg Gly Ala Gly Pro Arg Val Glu Met Ile Cys Gln Ala 
            660                 665                 670         


Ser Ser Gly Ser Pro Pro Ile Thr Asn Ser Leu Ile Gly Lys Asp Gly 
        675                 680                 685             


Gln Val His Leu Gln Gln Arg Pro Cys His Arg Gln Pro Ala Asn Phe 
    690                 695                 700                 


Ser Phe Leu Pro Ser Gln Thr Ser Asp Trp Phe Trp Cys Gln Ala Ala 
705                 710                 715                 720 


Asn Asn Ala Asn Val Gln His Ser Ala Leu Thr Val Val Pro Pro Gly 
                725                 730                 735     


Gly Asp Gln Lys Met Glu Asp Trp Gln Gly Pro Leu Glu Ser Pro Ile 
            740                 745                 750         


Leu Ala Leu Pro Leu Tyr Arg Ser Thr Arg Arg Leu Ser Glu Glu Glu 
        755                 760                 765             


Phe Gly Gly Phe Arg Ile Gly Asn Gly Glu Val Arg Gly Arg Lys Ala 
    770                 775                 780                 


Ala Ala Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
785                 790                 795                 800 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly 
                805                 810                 815     


Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His 
            820                 825                 830         


His His His His His 
        835         


<210>  314
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of canine IL-40 isoform X2 
       polyprotein.

<400>  314

Met Arg Leu Leu Leu Leu Leu Cys Leu Ala Leu Leu Ala Thr Cys Ser 
1               5                   10                  15      


Phe Ser Leu Glu Gln Glu Val Glu Val Thr Pro Glu Thr Phe Ile Ala 
            20                  25                  30          


Tyr Lys Val Arg Glu Val Phe Pro Ser Ser Arg Arg Val Val Ile Thr 
        35                  40                  45              


Cys His Ser Pro Arg Ala Pro Pro Pro Ile Thr Tyr Ser Leu Trp Gly 
    50                  55                  60                  


Ser Gln Gly Val Glu Val Ala Lys Lys Val Val Lys Thr Gly Asp Pro 
65                  70                  75                  80  


Ala Ser Phe Ser Ile Asn Ile Thr Leu Lys Ser Arg Pro Glu Leu Leu 
                85                  90                  95      


Thr Tyr Ser Cys Arg Ala Ala Ser Leu Arg Gly Glu His Ser Ala Ser 
            100                 105                 110         


Thr Lys Leu Gln Met Tyr Trp Glu Leu Trp Ala Lys Pro Met Ala Gln 
        115                 120                 125             


Pro Arg Ala Asn Phe Val Leu Leu Glu Arg Gly Ser Gly Pro Arg Val 
    130                 135                 140                 


Glu Ile Ser Cys Gln Val Ser Ser Gly Ser Pro Pro Ile Thr Tyr Ser 
145                 150                 155                 160 


Leu Val Arg Lys Asp Gly Tyr Val His Arg Gln Gln Arg Pro Thr Tyr 
                165                 170                 175     


Gly Gln Pro Ala Asn Phe Ser Phe Pro Leu Thr Arg Thr Ser Asn Trp 
            180                 185                 190         


Leu Arg Cys Gln Ala Ala Asn Asp Ile Ser Val Gln Ser Ser Pro Phe 
        195                 200                 205             


Arg Leu Val Pro Pro Gly Tyr Leu Pro Gln Gly Pro Val Leu Val Leu 
    210                 215                 220                 


Ala Gly Ser Leu Thr Ser Ile Ala Ala Val Thr Ser Trp Val Leu Gly 
225                 230                 235                 240 


Pro Ala Leu Trp Thr Arg Leu Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
                245                 250                 255     


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Met Arg 
            260                 265                 270         


Leu Leu Leu Leu Leu Cys Leu Ala Leu Leu Ala Thr Cys Ser Phe Ser 
        275                 280                 285             


Leu Glu Gln Glu Val Glu Val Thr Pro Glu Thr Phe Ile Ala Tyr Lys 
    290                 295                 300                 


Val Arg Glu Val Phe Pro Ser Ser Arg Arg Val Val Ile Thr Cys His 
305                 310                 315                 320 


Ser Pro Arg Ala Pro Pro Pro Ile Thr Tyr Ser Leu Trp Gly Ser Gln 
                325                 330                 335     


Gly Val Glu Val Ala Lys Lys Val Val Lys Thr Gly Asp Pro Ala Ser 
            340                 345                 350         


Phe Ser Ile Asn Ile Thr Leu Lys Ser Arg Pro Glu Leu Leu Thr Tyr 
        355                 360                 365             


Ser Cys Arg Ala Ala Ser Leu Arg Gly Glu His Ser Ala Ser Thr Lys 
    370                 375                 380                 


Leu Gln Met Tyr Trp Glu Leu Trp Ala Lys Pro Met Ala Gln Pro Arg 
385                 390                 395                 400 


Ala Asn Phe Val Leu Leu Glu Arg Gly Ser Gly Pro Arg Val Glu Ile 
                405                 410                 415     


Ser Cys Gln Val Ser Ser Gly Ser Pro Pro Ile Thr Tyr Ser Leu Val 
            420                 425                 430         


Arg Lys Asp Gly Tyr Val His Arg Gln Gln Arg Pro Thr Tyr Gly Gln 
        435                 440                 445             


Pro Ala Asn Phe Ser Phe Pro Leu Thr Arg Thr Ser Asn Trp Leu Arg 
    450                 455                 460                 


Cys Gln Ala Ala Asn Asp Ile Ser Val Gln Ser Ser Pro Phe Arg Leu 
465                 470                 475                 480 


Val Pro Pro Gly Tyr Leu Pro Gln Gly Pro Val Leu Val Leu Ala Gly 
                485                 490                 495     


Ser Leu Thr Ser Ile Ala Ala Val Thr Ser Trp Val Leu Gly Pro Ala 
            500                 505                 510         


Leu Trp Thr Arg Leu Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
        515                 520                 525             


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
    530                 535                 540                 


Gly Ser Met Arg Leu Leu Leu Leu Leu Cys Leu Ala Leu Leu Ala Thr 
545                 550                 555                 560 


Cys Ser Phe Ser Leu Glu Gln Glu Val Glu Val Thr Pro Glu Thr Phe 
                565                 570                 575     


Ile Ala Tyr Lys Val Arg Glu Val Phe Pro Ser Ser Arg Arg Val Val 
            580                 585                 590         


Ile Thr Cys His Ser Pro Arg Ala Pro Pro Pro Ile Thr Tyr Ser Leu 
        595                 600                 605             


Trp Gly Ser Gln Gly Val Glu Val Ala Lys Lys Val Val Lys Thr Gly 
    610                 615                 620                 


Asp Pro Ala Ser Phe Ser Ile Asn Ile Thr Leu Lys Ser Arg Pro Glu 
625                 630                 635                 640 


Leu Leu Thr Tyr Ser Cys Arg Ala Ala Ser Leu Arg Gly Glu His Ser 
                645                 650                 655     


Ala Ser Thr Lys Leu Gln Met Tyr Trp Glu Leu Trp Ala Lys Pro Met 
            660                 665                 670         


Ala Gln Pro Arg Ala Asn Phe Val Leu Leu Glu Arg Gly Ser Gly Pro 
        675                 680                 685             


Arg Val Glu Ile Ser Cys Gln Val Ser Ser Gly Ser Pro Pro Ile Thr 
    690                 695                 700                 


Tyr Ser Leu Val Arg Lys Asp Gly Tyr Val His Arg Gln Gln Arg Pro 
705                 710                 715                 720 


Thr Tyr Gly Gln Pro Ala Asn Phe Ser Phe Pro Leu Thr Arg Thr Ser 
                725                 730                 735     


Asn Trp Leu Arg Cys Gln Ala Ala Asn Asp Ile Ser Val Gln Ser Ser 
            740                 745                 750         


Pro Phe Arg Leu Val Pro Pro Gly Tyr Leu Pro Gln Gly Pro Val Leu 
        755                 760                 765             


Val Leu Ala Gly Ser Leu Thr Ser Ile Ala Ala Val Thr Ser Trp Val 
    770                 775                 780                 


Leu Gly Pro Ala Leu Trp Thr Arg Leu Ala Gly Ser Gly Phe Asn Asn 
785                 790                 795                 800 


Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His 
                805                 810                 815     


Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile 
            820                 825                 830         


Gly Ile Thr Glu Leu His His His His His His 
        835                 840             


<210>  315
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of human IL-41, Meteorin-like 
       protein polyprotein.

<400>  315

Gln Tyr Ser Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr His 
1               5                   10                  15      


Glu Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ala Ala 
            20                  25                  30          


Gly Ala Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu 
        35                  40                  45              


Arg Pro Asn Thr Phe Ser Pro Ala Arg His Leu Thr Val Cys Ile Arg 
    50                  55                  60                  


Ser Phe Thr Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly 
65                  70                  75                  80  


Glu Leu Arg Leu Leu Val Pro Asp Gly Asp Gly Arg Pro Gly Arg Val 
                85                  90                  95      


Gln Cys Phe Gly Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro 
            100                 105                 110         


Gln Gln Asp Ile Gly Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Val 
        115                 120                 125             


Arg Arg His Arg Ala Ser Asp Leu His Glu Leu Ser Ala Pro Cys Arg 
    130                 135                 140                 


Pro Cys Ser Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe 
145                 150                 155                 160 


Ala Val Arg Gly Ser Ile Gln Gln Val Thr His Glu Pro Glu Arg Gln 
                165                 170                 175     


Asp Ser Ala Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser 
            180                 185                 190         


Arg Val Phe Glu Pro Val Pro Glu Gly Asp Gly His Trp Gln Gly Arg 
        195                 200                 205             


Val Arg Thr Leu Leu Glu Cys Gly Val Arg Pro Gly His Gly Asp Phe 
    210                 215                 220                 


Leu Phe Thr Gly His Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala 
225                 230                 235                 240 


Pro Arg Phe Lys Asp Phe Gln Arg Met Tyr Arg Asp Ala Gln Glu Arg 
                245                 250                 255     


Gly Leu Asn Pro Cys Glu Val Gly Thr Asp Gly Ser Gly Gly Gln Tyr 
            260                 265                 270         


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser 
        275                 280                 285             


Gly Gln Tyr Ser Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr 
    290                 295                 300                 


His Glu Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ala 
305                 310                 315                 320 


Ala Gly Ala Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn 
                325                 330                 335     


Leu Arg Pro Asn Thr Phe Ser Pro Ala Arg His Leu Thr Val Cys Ile 
            340                 345                 350         


Arg Ser Phe Thr Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr 
        355                 360                 365             


Gly Glu Leu Arg Leu Leu Val Pro Asp Gly Asp Gly Arg Pro Gly Arg 
    370                 375                 380                 


Val Gln Cys Phe Gly Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr 
385                 390                 395                 400 


Pro Gln Gln Asp Ile Gly Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu 
                405                 410                 415     


Val Arg Arg His Arg Ala Ser Asp Leu His Glu Leu Ser Ala Pro Cys 
            420                 425                 430         


Arg Pro Cys Ser Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser Asp 
        435                 440                 445             


Phe Ala Val Arg Gly Ser Ile Gln Gln Val Thr His Glu Pro Glu Arg 
    450                 455                 460                 


Gln Asp Ser Ala Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys 
465                 470                 475                 480 


Ser Arg Val Phe Glu Pro Val Pro Glu Gly Asp Gly His Trp Gln Gly 
                485                 490                 495     


Arg Val Arg Thr Leu Leu Glu Cys Gly Val Arg Pro Gly His Gly Asp 
            500                 505                 510         


Phe Leu Phe Thr Gly His Met His Phe Gly Glu Ala Arg Leu Gly Cys 
        515                 520                 525             


Ala Pro Arg Phe Lys Asp Phe Gln Arg Met Tyr Arg Asp Ala Gln Glu 
    530                 535                 540                 


Arg Gly Leu Asn Pro Cys Glu Val Gly Thr Asp Ala Gly Ser Gly Phe 
545                 550                 555                 560 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
                565                 570                 575     


Ser His Leu Glu Ser Gly Gly Ser Gln Tyr Ser Ser Asp Arg Cys Ser 
            580                 585                 590         


Trp Lys Gly Ser Gly Leu Thr His Glu Ala His Arg Lys Glu Val Glu 
        595                 600                 605             


Gln Val Tyr Leu Arg Cys Ala Ala Gly Ala Val Glu Trp Met Tyr Pro 
    610                 615                 620                 


Thr Gly Ala Leu Ile Val Asn Leu Arg Pro Asn Thr Phe Ser Pro Ala 
625                 630                 635                 640 


Arg His Leu Thr Val Cys Ile Arg Ser Phe Thr Asp Ser Ser Gly Ala 
                645                 650                 655     


Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Arg Leu Leu Val Pro Asp 
            660                 665                 670         


Gly Asp Gly Arg Pro Gly Arg Val Gln Cys Phe Gly Leu Glu Gln Gly 
        675                 680                 685             


Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp Ile Gly Arg Arg Thr 
    690                 695                 700                 


Thr Gly Phe Gln Tyr Glu Leu Val Arg Arg His Arg Ala Ser Asp Leu 
705                 710                 715                 720 


His Glu Leu Ser Ala Pro Cys Arg Pro Cys Ser Asp Thr Glu Val Leu 
                725                 730                 735     


Leu Ala Val Cys Thr Ser Asp Phe Ala Val Arg Gly Ser Ile Gln Gln 
            740                 745                 750         


Val Thr His Glu Pro Glu Arg Gln Asp Ser Ala Ile His Leu Arg Val 
        755                 760                 765             


Ser Arg Leu Tyr Arg Gln Lys Ser Arg Val Phe Glu Pro Val Pro Glu 
    770                 775                 780                 


Gly Asp Gly His Trp Gln Gly Arg Val Arg Thr Leu Leu Glu Cys Gly 
785                 790                 795                 800 


Val Arg Pro Gly His Gly Asp Phe Leu Phe Thr Gly His Met His Phe 
                805                 810                 815     


Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe Lys Asp Phe Gln Arg 
            820                 825                 830         


Met Tyr Arg Asp Ala Gln Glu Arg Gly Leu Asn Pro Cys Glu Val Gly 
        835                 840                 845             


Thr Asp Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu 
    850                 855                 860                 


Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln 
865                 870                 875                 880 


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His 
                885                 890                 895     


His His His His 
            900 


<210>  316
<211>  990
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of canine IL-41, Meteorin-like 
       protein polyprotein.

<400>  316

Met Pro Pro Ser Val Met Ser Gln Met Cys Thr Phe Leu His Arg Gln 
1               5                   10                  15      


Gln Phe Cys Thr Asn Arg Ser Phe Phe Gly Phe Ala Val Ala Leu Glu 
            20                  25                  30          


His Arg Ser Glu Arg Phe Asp Gln Ile Phe Cys Gly Leu Thr His Glu 
        35                  40                  45              


Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ser Ala Gly 
    50                  55                  60                  


Ser Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Val Arg 
65                  70                  75                  80  


Pro Asn Thr Phe Pro Pro Ser Arg His Leu Thr Leu Cys Ile Lys Pro 
                85                  90                  95      


Leu Lys Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu 
            100                 105                 110         


Leu Lys Leu Leu Val Arg Asp Gly Asp Arg Gly Pro Gly Gln Val Arg 
        115                 120                 125             


Cys Phe Gly Phe Glu Gln Gly Gly Leu Phe Val Glu Ala Ala Pro Gln 
    130                 135                 140                 


Gln Asp Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Thr Ser 
145                 150                 155                 160 


Arg His Ala Glu Ser Asp Leu His Thr Leu Ser Ala Pro Cys Arg Pro 
                165                 170                 175     


Cys Ser Asp Ala Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe Val 
            180                 185                 190         


Val Arg Gly Ser Ile Gln Asn Val Thr His Val Pro Glu Gln Gln Glu 
        195                 200                 205             


Ser Ala Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser Arg 
    210                 215                 220                 


Val Phe Arg Pro Ala Pro Glu Gly Gly Gly Trp Arg Gly Arg Val Ala 
225                 230                 235                 240 


Thr Leu Leu Glu Cys Gly Val Arg Pro Gly Arg Gly Glu Phe Leu Phe 
                245                 250                 255     


Thr Gly His Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg 
            260                 265                 270         


Phe Lys Asp Phe Gln Arg Met Tyr Gln Asp Ala Glu Glu Arg Gly Leu 
        275                 280                 285             


Asn Pro Cys Glu Met Gly Lys Asp Gly Ser Gly Gly Gln Tyr Ile Lys 
    290                 295                 300                 


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Met 
305                 310                 315                 320 


Pro Pro Ser Val Met Ser Gln Met Cys Thr Phe Leu His Arg Gln Gln 
                325                 330                 335     


Phe Cys Thr Asn Arg Ser Phe Phe Gly Phe Ala Val Ala Leu Glu His 
            340                 345                 350         


Arg Ser Glu Arg Phe Asp Gln Ile Phe Cys Gly Leu Thr His Glu Ala 
        355                 360                 365             


His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ser Ala Gly Ser 
    370                 375                 380                 


Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Val Arg Pro 
385                 390                 395                 400 


Asn Thr Phe Pro Pro Ser Arg His Leu Thr Leu Cys Ile Lys Pro Leu 
                405                 410                 415     


Lys Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu 
            420                 425                 430         


Lys Leu Leu Val Arg Asp Gly Asp Arg Gly Pro Gly Gln Val Arg Cys 
        435                 440                 445             


Phe Gly Phe Glu Gln Gly Gly Leu Phe Val Glu Ala Ala Pro Gln Gln 
    450                 455                 460                 


Asp Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Thr Ser Arg 
465                 470                 475                 480 


His Ala Glu Ser Asp Leu His Thr Leu Ser Ala Pro Cys Arg Pro Cys 
                485                 490                 495     


Ser Asp Ala Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe Val Val 
            500                 505                 510         


Arg Gly Ser Ile Gln Asn Val Thr His Val Pro Glu Gln Gln Glu Ser 
        515                 520                 525             


Ala Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser Arg Val 
    530                 535                 540                 


Phe Arg Pro Ala Pro Glu Gly Gly Gly Trp Arg Gly Arg Val Ala Thr 
545                 550                 555                 560 


Leu Leu Glu Cys Gly Val Arg Pro Gly Arg Gly Glu Phe Leu Phe Thr 
                565                 570                 575     


Gly His Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe 
            580                 585                 590         


Lys Asp Phe Gln Arg Met Tyr Gln Asp Ala Glu Glu Arg Gly Leu Asn 
        595                 600                 605             


Pro Cys Glu Met Gly Lys Asp Ala Gly Ser Gly Phe Asn Asn Phe Thr 
    610                 615                 620                 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
625                 630                 635                 640 


Ser Gly Gly Ser Met Pro Pro Ser Val Met Ser Gln Met Cys Thr Phe 
                645                 650                 655     


Leu His Arg Gln Gln Phe Cys Thr Asn Arg Ser Phe Phe Gly Phe Ala 
            660                 665                 670         


Val Ala Leu Glu His Arg Ser Glu Arg Phe Asp Gln Ile Phe Cys Gly 
        675                 680                 685             


Leu Thr His Glu Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg 
    690                 695                 700                 


Cys Ser Ala Gly Ser Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile 
705                 710                 715                 720 


Val Asn Val Arg Pro Asn Thr Phe Pro Pro Ser Arg His Leu Thr Leu 
                725                 730                 735     


Cys Ile Lys Pro Leu Lys Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu 
            740                 745                 750         


Lys Thr Gly Glu Leu Lys Leu Leu Val Arg Asp Gly Asp Arg Gly Pro 
        755                 760                 765             


Gly Gln Val Arg Cys Phe Gly Phe Glu Gln Gly Gly Leu Phe Val Glu 
    770                 775                 780                 


Ala Ala Pro Gln Gln Asp Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr 
785                 790                 795                 800 


Glu Leu Thr Ser Arg His Ala Glu Ser Asp Leu His Thr Leu Ser Ala 
                805                 810                 815     


Pro Cys Arg Pro Cys Ser Asp Ala Glu Val Leu Leu Ala Val Cys Thr 
            820                 825                 830         


Ser Asp Phe Val Val Arg Gly Ser Ile Gln Asn Val Thr His Val Pro 
        835                 840                 845             


Glu Gln Gln Glu Ser Ala Ile His Leu Arg Val Ser Arg Leu Tyr Arg 
    850                 855                 860                 


Gln Lys Ser Arg Val Phe Arg Pro Ala Pro Glu Gly Gly Gly Trp Arg 
865                 870                 875                 880 


Gly Arg Val Ala Thr Leu Leu Glu Cys Gly Val Arg Pro Gly Arg Gly 
                885                 890                 895     


Glu Phe Leu Phe Thr Gly His Met His Phe Gly Glu Ala Arg Leu Gly 
            900                 905                 910         


Cys Ala Pro Arg Phe Lys Asp Phe Gln Arg Met Tyr Gln Asp Ala Glu 
        915                 920                 925             


Glu Arg Gly Leu Asn Pro Cys Glu Met Gly Lys Asp Ala Gly Ser Gly 
    930                 935                 940                 


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
945                 950                 955                 960 


Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser 
                965                 970                 975     


Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
            980                 985                 990 


<210>  317
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of felis IL-41, Meteorin-like 
       protein polyprotein.

<400>  317

Gln Tyr Ser Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr His 
1               5                   10                  15      


Glu Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ser Ala 
            20                  25                  30          


Gly Ser Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Val 
        35                  40                  45              


Arg Pro Asn Thr Phe Pro Pro Ser Arg Arg His Leu Thr Leu Cys Ile 
    50                  55                  60                  


Lys Pro Leu Arg Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr 
65                  70                  75                  80  


Gly Glu Leu Gln Leu Leu Val Arg Asp Gly Asp Arg Gly Pro Arg Gln 
                85                  90                  95      


Val His Cys Phe Gly Phe Glu Gln Arg Gly Leu Phe Val Glu Ala Thr 
            100                 105                 110         


Pro Gln Gln Asp Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu 
        115                 120                 125             


Thr Ser Arg His Ala Glu Ser Asp Leu Arg Ala Gln Ser Ala Pro Cys 
    130                 135                 140                 


Arg Pro Cys Ser Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser Asp 
145                 150                 155                 160 


Phe Val Val Arg Gly Ser Ile Gln Asp Val Thr His Glu Pro Glu Gln 
                165                 170                 175     


Gln Glu Ser Ala Ile His Leu His Val Asn Arg Leu Tyr Arg Gln Lys 
            180                 185                 190         


Ser Thr Val Phe Arg Pro Ala Pro Glu Gly Gly Gly Trp Arg Gly His 
        195                 200                 205             


Val Thr Thr Leu Leu Glu Cys Gly Val Arg Pro Gly Arg Gly Glu Phe 
    210                 215                 220                 


Leu Phe Thr Gly Pro Ile His Phe Gly Glu Ala His Leu Gly Cys Ala 
225                 230                 235                 240 


Pro Arg Phe Lys Asp Phe Gln Arg Met Tyr Lys Asp Ala Glu Glu Lys 
                245                 250                 255     


Gly Leu Asn Pro Cys Glu Met Gly Thr Glu Gly Ser Gly Gly Gln Tyr 
            260                 265                 270         


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser 
        275                 280                 285             


Gly Gln Tyr Ser Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr 
    290                 295                 300                 


His Glu Ala His Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ser 
305                 310                 315                 320 


Ala Gly Ser Val Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn 
                325                 330                 335     


Val Arg Pro Asn Thr Phe Pro Pro Ser Arg Arg His Leu Thr Leu Cys 
            340                 345                 350         


Ile Lys Pro Leu Arg Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys 
        355                 360                 365             


Thr Gly Glu Leu Gln Leu Leu Val Arg Asp Gly Asp Arg Gly Pro Arg 
    370                 375                 380                 


Gln Val His Cys Phe Gly Phe Glu Gln Arg Gly Leu Phe Val Glu Ala 
385                 390                 395                 400 


Thr Pro Gln Gln Asp Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr Glu 
                405                 410                 415     


Leu Thr Ser Arg His Ala Glu Ser Asp Leu Arg Ala Gln Ser Ala Pro 
            420                 425                 430         


Cys Arg Pro Cys Ser Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser 
        435                 440                 445             


Asp Phe Val Val Arg Gly Ser Ile Gln Asp Val Thr His Glu Pro Glu 
    450                 455                 460                 


Gln Gln Glu Ser Ala Ile His Leu His Val Asn Arg Leu Tyr Arg Gln 
465                 470                 475                 480 


Lys Ser Thr Val Phe Arg Pro Ala Pro Glu Gly Gly Gly Trp Arg Gly 
                485                 490                 495     


His Val Thr Thr Leu Leu Glu Cys Gly Val Arg Pro Gly Arg Gly Glu 
            500                 505                 510         


Phe Leu Phe Thr Gly Pro Ile His Phe Gly Glu Ala His Leu Gly Cys 
        515                 520                 525             


Ala Pro Arg Phe Lys Asp Phe Gln Arg Met Tyr Lys Asp Ala Glu Glu 
    530                 535                 540                 


Lys Gly Leu Asn Pro Cys Glu Met Gly Thr Glu Ala Gly Ser Gly Phe 
545                 550                 555                 560 


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
                565                 570                 575     


Ser His Leu Glu Ser Gly Gly Ser Gln Tyr Ser Ser Asp Arg Cys Ser 
            580                 585                 590         


Trp Lys Gly Ser Gly Leu Thr His Glu Ala His Arg Lys Glu Val Glu 
        595                 600                 605             


Gln Val Tyr Leu Arg Cys Ser Ala Gly Ser Val Glu Trp Met Tyr Pro 
    610                 615                 620                 


Thr Gly Ala Leu Ile Val Asn Val Arg Pro Asn Thr Phe Pro Pro Ser 
625                 630                 635                 640 


Arg Arg His Leu Thr Leu Cys Ile Lys Pro Leu Arg Asp Ser Ser Gly 
                645                 650                 655     


Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Gln Leu Leu Val Arg 
            660                 665                 670         


Asp Gly Asp Arg Gly Pro Arg Gln Val His Cys Phe Gly Phe Glu Gln 
        675                 680                 685             


Arg Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp Ile Ser Arg Arg 
    690                 695                 700                 


Thr Thr Gly Phe Gln Tyr Glu Leu Thr Ser Arg His Ala Glu Ser Asp 
705                 710                 715                 720 


Leu Arg Ala Gln Ser Ala Pro Cys Arg Pro Cys Ser Asp Thr Glu Val 
                725                 730                 735     


Leu Leu Ala Val Cys Thr Ser Asp Phe Val Val Arg Gly Ser Ile Gln 
            740                 745                 750         


Asp Val Thr His Glu Pro Glu Gln Gln Glu Ser Ala Ile His Leu His 
        755                 760                 765             


Val Asn Arg Leu Tyr Arg Gln Lys Ser Thr Val Phe Arg Pro Ala Pro 
    770                 775                 780                 


Glu Gly Gly Gly Trp Arg Gly His Val Thr Thr Leu Leu Glu Cys Gly 
785                 790                 795                 800 


Val Arg Pro Gly Arg Gly Glu Phe Leu Phe Thr Gly Pro Ile His Phe 
                805                 810                 815     


Gly Glu Ala His Leu Gly Cys Ala Pro Arg Phe Lys Asp Phe Gln Arg 
            820                 825                 830         


Met Tyr Lys Asp Ala Glu Glu Lys Gly Leu Asn Pro Cys Glu Met Gly 
        835                 840                 845             


Thr Glu Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu 
    850                 855                 860                 


Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln 
865                 870                 875                 880 


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His 
                885                 890                 895     


His His His His 
            900 


<210>  318
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine interferon-gamma 
       polyprotein.

<400>  318

Gln Gly Gln Phe Phe Arg Glu Ile Glu Asn Leu Lys Glu Tyr Phe Asn 
1               5                   10                  15      


Ala Ser Ser Pro Asp Val Ala Lys Gly Gly Pro Leu Phe Ser Glu Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Asp Glu Ser Asp Lys Lys Ile Ile Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Phe Lys Leu Phe Glu Asn Leu Lys Asp Asn Gln 
    50                  55                  60                  


Val Ile Gln Arg Ser Met Asp Ile Ile Lys Gln Asp Met Phe Gln Lys 
65                  70                  75                  80  


Phe Leu Asn Gly Ser Ser Glu Lys Leu Glu Asp Phe Lys Lys Leu Ile 
                85                  90                  95      


Gln Ile Pro Val Asp Asp Leu Gln Ile Gln Arg Lys Ala Ile Asn Glu 
            100                 105                 110         


Leu Ile Lys Val Met Asn Asp Leu Ser Pro Lys Ser Asn Leu Arg Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly Arg Arg Ala Ser Met Gly 
    130                 135                 140                 


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
145                 150                 155                 160 


Glu Leu Ala Gly Ser Gly Gln Gly Gln Phe Phe Arg Glu Ile Glu Asn 
                165                 170                 175     


Leu Lys Glu Tyr Phe Asn Ala Ser Ser Pro Asp Val Ala Lys Gly Gly 
            180                 185                 190         


Pro Leu Phe Ser Glu Ile Leu Lys Asn Trp Lys Asp Glu Ser Asp Lys 
        195                 200                 205             


Lys Ile Ile Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Glu 
    210                 215                 220                 


Asn Leu Lys Asp Asn Gln Val Ile Gln Arg Ser Met Asp Ile Ile Lys 
225                 230                 235                 240 


Gln Asp Met Phe Gln Lys Phe Leu Asn Gly Ser Ser Glu Lys Leu Glu 
                245                 250                 255     


Asp Phe Lys Lys Leu Ile Gln Ile Pro Val Asp Asp Leu Gln Ile Gln 
            260                 265                 270         


Arg Lys Ala Ile Asn Glu Leu Ile Lys Val Met Asn Asp Leu Ser Pro 
        275                 280                 285             


Lys Ser Asn Leu Arg Lys Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly 
    290                 295                 300                 


Arg Arg Ala Ser Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
305                 310                 315                 320 


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
                325                 330                 335     


Gly Ser Gln Gly Gln Phe Phe Arg Glu Ile Glu Asn Leu Lys Glu Tyr 
            340                 345                 350         


Phe Asn Ala Ser Ser Pro Asp Val Ala Lys Gly Gly Pro Leu Phe Ser 
        355                 360                 365             


Glu Ile Leu Lys Asn Trp Lys Asp Glu Ser Asp Lys Lys Ile Ile Gln 
    370                 375                 380                 


Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Glu Asn Leu Lys Asp 
385                 390                 395                 400 


Asn Gln Val Ile Gln Arg Ser Met Asp Ile Ile Lys Gln Asp Met Phe 
                405                 410                 415     


Gln Lys Phe Leu Asn Gly Ser Ser Glu Lys Leu Glu Asp Phe Lys Lys 
            420                 425                 430         


Leu Ile Gln Ile Pro Val Asp Asp Leu Gln Ile Gln Arg Lys Ala Ile 
        435                 440                 445             


Asn Glu Leu Ile Lys Val Met Asn Asp Leu Ser Pro Lys Ser Asn Leu 
    450                 455                 460                 


Arg Lys Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly Arg Arg Ala Ser 
465                 470                 475                 480 


Met Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
                485                 490                 495     


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
            500                 505                 510         


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
        515                 520                 525             


His His His 
    530     


<210>  319
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of canis interferon-gamma 
       polyprotein.

<400>  319

Gln Ala Met Phe Phe Lys Glu Ile Glu Asn Leu Lys Glu Tyr Phe Asn 
1               5                   10                  15      


Ala Ser Asn Pro Asp Val Ser Asp Gly Gly Ser Leu Phe Val Asp Ile 
            20                  25                  30          


Leu Lys Lys Trp Arg Glu Glu Ser Asp Lys Thr Ile Ile Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Leu Lys Leu Phe Asp Asn Phe Lys Asp Asn Gln 
    50                  55                  60                  


Ile Ile Gln Arg Ser Met Asp Thr Ile Lys Glu Asp Met Leu Gly Lys 
65                  70                  75                  80  


Phe Leu Asn Ser Ser Thr Ser Lys Arg Glu Asp Phe Leu Lys Leu Ile 
                85                  90                  95      


Gln Ile Pro Val Asn Asp Leu Gln Val Gln Arg Lys Ala Ile Asn Glu 
            100                 105                 110         


Leu Ile Lys Val Met Asn Asp Leu Ser Pro Arg Ser Asn Leu Arg Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly Arg Arg Ala Ser Lys Gly 
    130                 135                 140                 


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
145                 150                 155                 160 


Glu Leu Ala Gly Ser Gly Gln Ala Met Phe Phe Lys Glu Ile Glu Asn 
                165                 170                 175     


Leu Lys Glu Tyr Phe Asn Ala Ser Asn Pro Asp Val Ser Asp Gly Gly 
            180                 185                 190         


Ser Leu Phe Val Asp Ile Leu Lys Lys Trp Arg Glu Glu Ser Asp Lys 
        195                 200                 205             


Thr Ile Ile Gln Ser Gln Ile Val Ser Phe Tyr Leu Lys Leu Phe Asp 
    210                 215                 220                 


Asn Phe Lys Asp Asn Gln Ile Ile Gln Arg Ser Met Asp Thr Ile Lys 
225                 230                 235                 240 


Glu Asp Met Leu Gly Lys Phe Leu Asn Ser Ser Thr Ser Lys Arg Glu 
                245                 250                 255     


Asp Phe Leu Lys Leu Ile Gln Ile Pro Val Asn Asp Leu Gln Val Gln 
            260                 265                 270         


Arg Lys Ala Ile Asn Glu Leu Ile Lys Val Met Asn Asp Leu Ser Pro 
        275                 280                 285             


Arg Ser Asn Leu Arg Lys Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly 
    290                 295                 300                 


Arg Arg Ala Ser Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
305                 310                 315                 320 


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
                325                 330                 335     


Gly Ser Gln Ala Met Phe Phe Lys Glu Ile Glu Asn Leu Lys Glu Tyr 
            340                 345                 350         


Phe Asn Ala Ser Asn Pro Asp Val Ser Asp Gly Gly Ser Leu Phe Val 
        355                 360                 365             


Asp Ile Leu Lys Lys Trp Arg Glu Glu Ser Asp Lys Thr Ile Ile Gln 
    370                 375                 380                 


Ser Gln Ile Val Ser Phe Tyr Leu Lys Leu Phe Asp Asn Phe Lys Asp 
385                 390                 395                 400 


Asn Gln Ile Ile Gln Arg Ser Met Asp Thr Ile Lys Glu Asp Met Leu 
                405                 410                 415     


Gly Lys Phe Leu Asn Ser Ser Thr Ser Lys Arg Glu Asp Phe Leu Lys 
            420                 425                 430         


Leu Ile Gln Ile Pro Val Asn Asp Leu Gln Val Gln Arg Lys Ala Ile 
        435                 440                 445             


Asn Glu Leu Ile Lys Val Met Asn Asp Leu Ser Pro Arg Ser Asn Leu 
    450                 455                 460                 


Arg Lys Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly Arg Arg Ala Ser 
465                 470                 475                 480 


Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
                485                 490                 495     


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
            500                 505                 510         


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
        515                 520                 525             


His His His 
    530     


<210>  320
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of felis interferon-gamma 
       polyprotein.

<400>  320

Gln Ala Met Phe Phe Lys Glu Ile Glu Glu Leu Lys Gly Tyr Phe Asn 
1               5                   10                  15      


Ala Ser Asn Pro Asp Val Ala Asp Gly Gly Ser Leu Phe Val Asp Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Glu Glu Ser Asp Lys Thr Ile Ile Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Leu Lys Met Phe Glu Asn Leu Lys Asp Asp Asp 
    50                  55                  60                  


Gln Arg Ile Gln Arg Ser Met Asp Thr Ile Lys Glu Asp Met Leu Asp 
65                  70                  75                  80  


Lys Leu Leu Asn Thr Ser Ser Ser Lys Arg Asp Asp Phe Leu Lys Leu 
                85                  90                  95      


Ile Gln Ile Pro Val Asn Asp Leu Gln Val Gln Arg Lys Ala Ile Asn 
            100                 105                 110         


Glu Leu Phe Lys Val Met Asn Asp Leu Ser Pro Arg Ser Asn Leu Arg 
        115                 120                 125             


Lys Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly Arg Arg Ala Ser Lys 
    130                 135                 140                 


Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
145                 150                 155                 160 


Thr Glu Leu Ala Gly Ser Gly Gln Ala Met Phe Phe Lys Glu Ile Glu 
                165                 170                 175     


Glu Leu Lys Gly Tyr Phe Asn Ala Ser Asn Pro Asp Val Ala Asp Gly 
            180                 185                 190         


Gly Ser Leu Phe Val Asp Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
        195                 200                 205             


Lys Thr Ile Ile Gln Ser Gln Ile Val Ser Phe Tyr Leu Lys Met Phe 
    210                 215                 220                 


Glu Asn Leu Lys Asp Asp Asp Gln Arg Ile Gln Arg Ser Met Asp Thr 
225                 230                 235                 240 


Ile Lys Glu Asp Met Leu Asp Lys Leu Leu Asn Thr Ser Ser Ser Lys 
                245                 250                 255     


Arg Asp Asp Phe Leu Lys Leu Ile Gln Ile Pro Val Asn Asp Leu Gln 
            260                 265                 270         


Val Gln Arg Lys Ala Ile Asn Glu Leu Phe Lys Val Met Asn Asp Leu 
        275                 280                 285             


Ser Pro Arg Ser Asn Leu Arg Lys Arg Lys Arg Ser Gln Asn Leu Phe 
    290                 295                 300                 


Arg Gly Arg Arg Ala Ser Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr 
305                 310                 315                 320 


Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu 
                325                 330                 335     


Ser Gly Gly Ser Gln Ala Met Phe Phe Lys Glu Ile Glu Glu Leu Lys 
            340                 345                 350         


Gly Tyr Phe Asn Ala Ser Asn Pro Asp Val Ala Asp Gly Gly Ser Leu 
        355                 360                 365             


Phe Val Asp Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Lys Thr Ile 
    370                 375                 380                 


Ile Gln Ser Gln Ile Val Ser Phe Tyr Leu Lys Met Phe Glu Asn Leu 
385                 390                 395                 400 


Lys Asp Asp Asp Gln Arg Ile Gln Arg Ser Met Asp Thr Ile Lys Glu 
                405                 410                 415     


Asp Met Leu Asp Lys Leu Leu Asn Thr Ser Ser Ser Lys Arg Asp Asp 
            420                 425                 430         


Phe Leu Lys Leu Ile Gln Ile Pro Val Asn Asp Leu Gln Val Gln Arg 
        435                 440                 445             


Lys Ala Ile Asn Glu Leu Phe Lys Val Met Asn Asp Leu Ser Pro Arg 
    450                 455                 460                 


Ser Asn Leu Arg Lys Arg Lys Arg Ser Gln Asn Leu Phe Arg Gly Arg 
465                 470                 475                 480 


Arg Ala Ser Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe 
                485                 490                 495     


Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly 
            500                 505                 510         


Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
        515                 520                 525             


His His His His His His 
    530                 


<210>  321
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine interferon-alpha A 
       polyprotein.

<400>  321

Cys His Leu Pro His Thr His Ser Leu Ala Asn Arg Arg Val Leu Met 
1               5                   10                  15      


Leu Leu Gln Gln Leu Arg Arg Val Ser Pro Ser Ser Cys Leu Gln Asp 
            20                  25                  30          


Arg Asn Asp Phe Glu Phe Leu Gln Glu Ala Leu Gly Gly Ser Gln Leu 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Val Thr Gln His Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Pro Ala Thr Trp Asp Lys Ser 
65                  70                  75                  80  


Leu Leu Asp Lys Leu Arg Ala Ala Leu Asp Gln Gln Leu Thr Asp Leu 
                85                  90                  95      


Gln Ala Cys Leu Thr Gln Glu Glu Gly Leu Arg Gly Ala Pro Leu Leu 
            100                 105                 110         


Lys Glu Asp Ser Ser Leu Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Arg His Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ala Phe Ser Ser Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Ser Phe Arg Arg Lys Asp Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn 
                165                 170                 175     


Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Cys His Leu 
            180                 185                 190         


Pro His Thr His Ser Leu Ala Asn Arg Arg Val Leu Met Leu Leu Gln 
        195                 200                 205             


Gln Leu Arg Arg Val Ser Pro Ser Ser Cys Leu Gln Asp Arg Asn Asp 
    210                 215                 220                 


Phe Glu Phe Leu Gln Glu Ala Leu Gly Gly Ser Gln Leu Gln Lys Ala 
225                 230                 235                 240 


Gln Ala Ile Ser Val Leu His Glu Val Thr Gln His Thr Phe Gln Leu 
                245                 250                 255     


Phe Ser Thr Glu Gly Ser Pro Ala Thr Trp Asp Lys Ser Leu Leu Asp 
            260                 265                 270         


Lys Leu Arg Ala Ala Leu Asp Gln Gln Leu Thr Asp Leu Gln Ala Cys 
        275                 280                 285             


Leu Thr Gln Glu Glu Gly Leu Arg Gly Ala Pro Leu Leu Lys Glu Asp 
    290                 295                 300                 


Ser Ser Leu Ala Val Arg Lys Tyr Phe His Arg Leu Thr Leu Tyr Leu 
305                 310                 315                 320 


Gln Glu Lys Arg His Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
                325                 330                 335     


Val Met Arg Ala Phe Ser Ser Ser Thr Asn Leu Gln Glu Ser Phe Arg 
            340                 345                 350         


Arg Lys Asp Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
        355                 360                 365             


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
    370                 375                 380                 


Cys His Leu Pro His Thr His Ser Leu Ala Asn Arg Arg Val Leu Met 
385                 390                 395                 400 


Leu Leu Gln Gln Leu Arg Arg Val Ser Pro Ser Ser Cys Leu Gln Asp 
                405                 410                 415     


Arg Asn Asp Phe Glu Phe Leu Gln Glu Ala Leu Gly Gly Ser Gln Leu 
            420                 425                 430         


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Val Thr Gln His Thr 
        435                 440                 445             


Phe Gln Leu Phe Ser Thr Glu Gly Ser Pro Ala Thr Trp Asp Lys Ser 
    450                 455                 460                 


Leu Leu Asp Lys Leu Arg Ala Ala Leu Asp Gln Gln Leu Thr Asp Leu 
465                 470                 475                 480 


Gln Ala Cys Leu Thr Gln Glu Glu Gly Leu Arg Gly Ala Pro Leu Leu 
                485                 490                 495     


Lys Glu Asp Ser Ser Leu Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
            500                 505                 510         


Leu Tyr Leu Gln Glu Lys Arg His Ser Pro Cys Ala Trp Glu Val Val 
        515                 520                 525             


Arg Ala Glu Val Met Arg Ala Phe Ser Ser Ser Thr Asn Leu Gln Glu 
    530                 535                 540                 


Ser Phe Arg Arg Lys Asp Ala Gly Ser Gly Phe Asn Asn Phe Thr Val 
545                 550                 555                 560 


Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly 
                565                 570                 575     


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
            580                 585                 590         


Glu Leu His His His His His His 
        595                 600 


<210>  322
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of canine interferon-alpha 1 of 2
       polyprotein.

<400>  322

Cys His Leu Pro Asp Thr His Gly Leu Arg Asn Trp Arg Val Leu Thr 
1               5                   10                  15      


Leu Leu Gly Gln Met Arg Arg Leu Ser Ala Gly Ser Cys Asp His Tyr 
            20                  25                  30          


Thr Asn Asp Phe Ala Phe Pro Lys Glu Leu Phe Asp Gly Gln Arg Leu 
        35                  40                  45              


Gln Glu Ala Gln Ala Leu Ser Val Val His Val Met Thr Gln Lys Val 
    50                  55                  60                  


Phe His Leu Phe Cys Pro Asp Thr Ser Ser Ala Pro Trp Asn Met Thr 
65                  70                  75                  80  


Leu Leu Glu Glu Leu Cys Ser Gly Leu Ser Glu Gln Leu Asp Asp Leu 
                85                  90                  95      


Glu Ala Cys Pro Leu Gln Glu Ala Gly Leu Ala Glu Thr Pro Leu Met 
            100                 105                 110         


His Glu Asp Ser Thr Leu Arg Thr Tyr Phe Gln Arg Ile Ser Leu Tyr 
        115                 120                 125             


Leu Gln Asp Arg Asn His Ser Pro Cys Ala Trp Glu Met Val Arg Ala 
    130                 135                 140                 


Glu Ile Gly Arg Ser Phe Phe Ser Ser Thr Ile Leu Gln Glu Arg Ile 
145                 150                 155                 160 


Arg Arg Arg Lys Gly Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys 
                165                 170                 175     


Phe Ile Gly Ile Thr Glu Leu Ala Gly Ser Gly Cys His Leu Pro Asp 
            180                 185                 190         


Thr His Gly Leu Arg Asn Trp Arg Val Leu Thr Leu Leu Gly Gln Met 
        195                 200                 205             


Arg Arg Leu Ser Ala Gly Ser Cys Asp His Tyr Thr Asn Asp Phe Ala 
    210                 215                 220                 


Phe Pro Lys Glu Leu Phe Asp Gly Gln Arg Leu Gln Glu Ala Gln Ala 
225                 230                 235                 240 


Leu Ser Val Val His Val Met Thr Gln Lys Val Phe His Leu Phe Cys 
                245                 250                 255     


Pro Asp Thr Ser Ser Ala Pro Trp Asn Met Thr Leu Leu Glu Glu Leu 
            260                 265                 270         


Cys Ser Gly Leu Ser Glu Gln Leu Asp Asp Leu Glu Ala Cys Pro Leu 
        275                 280                 285             


Gln Glu Ala Gly Leu Ala Glu Thr Pro Leu Met His Glu Asp Ser Thr 
    290                 295                 300                 


Leu Arg Thr Tyr Phe Gln Arg Ile Ser Leu Tyr Leu Gln Asp Arg Asn 
305                 310                 315                 320 


His Ser Pro Cys Ala Trp Glu Met Val Arg Ala Glu Ile Gly Arg Ser 
                325                 330                 335     


Phe Phe Ser Ser Thr Ile Leu Gln Glu Arg Ile Arg Arg Arg Lys Ala 
            340                 345                 350         


Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro 
        355                 360                 365             


Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser Cys His Leu Pro 
    370                 375                 380                 


Asp Thr His Gly Leu Arg Asn Trp Arg Val Leu Thr Leu Leu Gly Gln 
385                 390                 395                 400 


Met Arg Arg Leu Ser Ala Gly Ser Cys Asp His Tyr Thr Asn Asp Phe 
                405                 410                 415     


Ala Phe Pro Lys Glu Leu Phe Asp Gly Gln Arg Leu Gln Glu Ala Gln 
            420                 425                 430         


Ala Leu Ser Val Val His Val Met Thr Gln Lys Val Phe His Leu Phe 
        435                 440                 445             


Cys Pro Asp Thr Ser Ser Ala Pro Trp Asn Met Thr Leu Leu Glu Glu 
    450                 455                 460                 


Leu Cys Ser Gly Leu Ser Glu Gln Leu Asp Asp Leu Glu Ala Cys Pro 
465                 470                 475                 480 


Leu Gln Glu Ala Gly Leu Ala Glu Thr Pro Leu Met His Glu Asp Ser 
                485                 490                 495     


Thr Leu Arg Thr Tyr Phe Gln Arg Ile Ser Leu Tyr Leu Gln Asp Arg 
            500                 505                 510         


Asn His Ser Pro Cys Ala Trp Glu Met Val Arg Ala Glu Ile Gly Arg 
        515                 520                 525             


Ser Phe Phe Ser Ser Thr Ile Leu Gln Glu Arg Ile Arg Arg Arg Lys 
    530                 535                 540                 


Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val 
545                 550                 555                 560 


Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile 
                565                 570                 575     


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His 
            580                 585                 590         


His His 
        


<210>  323
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of feline interferon-alpha 
       polyprotein.

<400>  323

Cys Asp Leu Pro Gln Thr His Gly Leu Leu Asn Arg Arg Ala Leu Thr 
1               5                   10                  15      


Leu Leu Gly Gln Met Arg Arg Leu Pro Ala Ser Ser Cys Gln Lys Asp 
            20                  25                  30          


Arg Asn Asp Phe Ala Phe Pro Gln Asp Val Phe Gly Gly Asp Gln Ser 
        35                  40                  45              


His Lys Ala Gln Ala Leu Ser Val Val His Val Thr Asn Gln Lys Ile 
    50                  55                  60                  


Phe His Phe Phe Cys Thr Glu Ala Ser Ser Ser Ala Ala Trp Asn Thr 
65                  70                  75                  80  


Thr Leu Leu Glu Glu Phe Cys Thr Gly Leu Asp Arg Gln Leu Thr Arg 
                85                  90                  95      


Leu Glu Ala Cys Val Leu Gln Glu Val Glu Glu Gly Glu Ala Pro Leu 
            100                 105                 110         


Thr Asn Glu Asp Ile His Pro Glu Asp Ser Ile Leu Arg Asn Tyr Phe 
        115                 120                 125             


Gln Arg Leu Ser Leu Tyr Leu Gln Glu Lys Lys Tyr Ser Pro Cys Ala 
    130                 135                 140                 


Trp Glu Ile Val Arg Ala Glu Ile Met Arg Ser Leu Tyr Tyr Ser Ser 
145                 150                 155                 160 


Thr Ala Leu Gln Lys Arg Leu Arg Ser Glu Lys Gly Ser Gly Gly Gln 
                165                 170                 175     


Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Ala Gly 
            180                 185                 190         


Ser Gly Cys Asp Leu Pro Gln Thr His Gly Leu Leu Asn Arg Arg Ala 
        195                 200                 205             


Leu Thr Leu Leu Gly Gln Met Arg Arg Leu Pro Ala Ser Ser Cys Gln 
    210                 215                 220                 


Lys Asp Arg Asn Asp Phe Ala Phe Pro Gln Asp Val Phe Gly Gly Asp 
225                 230                 235                 240 


Gln Ser His Lys Ala Gln Ala Leu Ser Val Val His Val Thr Asn Gln 
                245                 250                 255     


Lys Ile Phe His Phe Phe Cys Thr Glu Ala Ser Ser Ser Ala Ala Trp 
            260                 265                 270         


Asn Thr Thr Leu Leu Glu Glu Phe Cys Thr Gly Leu Asp Arg Gln Leu 
        275                 280                 285             


Thr Arg Leu Glu Ala Cys Val Leu Gln Glu Val Glu Glu Gly Glu Ala 
    290                 295                 300                 


Pro Leu Thr Asn Glu Asp Ile His Pro Glu Asp Ser Ile Leu Arg Asn 
305                 310                 315                 320 


Tyr Phe Gln Arg Leu Ser Leu Tyr Leu Gln Glu Lys Lys Tyr Ser Pro 
                325                 330                 335     


Cys Ala Trp Glu Ile Val Arg Ala Glu Ile Met Arg Ser Leu Tyr Tyr 
            340                 345                 350         


Ser Ser Thr Ala Leu Gln Lys Arg Leu Arg Ser Glu Lys Ala Gly Ser 
        355                 360                 365             


Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
    370                 375                 380                 


Ser Ala Ser His Leu Glu Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr 
385                 390                 395                 400 


His Gly Leu Leu Asn Arg Arg Ala Leu Thr Leu Leu Gly Gln Met Arg 
                405                 410                 415     


Arg Leu Pro Ala Ser Ser Cys Gln Lys Asp Arg Asn Asp Phe Ala Phe 
            420                 425                 430         


Pro Gln Asp Val Phe Gly Gly Asp Gln Ser His Lys Ala Gln Ala Leu 
        435                 440                 445             


Ser Val Val His Val Thr Asn Gln Lys Ile Phe His Phe Phe Cys Thr 
    450                 455                 460                 


Glu Ala Ser Ser Ser Ala Ala Trp Asn Thr Thr Leu Leu Glu Glu Phe 
465                 470                 475                 480 


Cys Thr Gly Leu Asp Arg Gln Leu Thr Arg Leu Glu Ala Cys Val Leu 
                485                 490                 495     


Gln Glu Val Glu Glu Gly Glu Ala Pro Leu Thr Asn Glu Asp Ile His 
            500                 505                 510         


Pro Glu Asp Ser Ile Leu Arg Asn Tyr Phe Gln Arg Leu Ser Leu Tyr 
        515                 520                 525             


Leu Gln Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Ile Val Arg Ala 
    530                 535                 540                 


Glu Ile Met Arg Ser Leu Tyr Tyr Ser Ser Thr Ala Leu Gln Lys Arg 
545                 550                 555                 560 


Leu Arg Ser Glu Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
                565                 570                 575     


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser 
            580                 585                 590         


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
        595                 600                 605             


Leu His His His His His His 
    610                 615 


<210>  324
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine Granulocyte-macrophage 
       colony-stimulating factor polyprotein.

<400>  324

Ala Pro Thr Arg Pro Pro Asn Thr Ala Thr Arg Pro Trp Gln His Val 
1               5                   10                  15      


Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu Asn His Ser Ser Asp Thr 
            20                  25                  30          


Asp Ala Val Met Asn Asp Thr Glu Val Val Ser Glu Lys Phe Asp Ser 
        35                  40                  45              


Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Lys Leu Tyr Lys Asn Gly 
    50                  55                  60                  


Leu Gln Gly Ser Leu Thr Ser Leu Met Gly Ser Leu Thr Met Met Ala 
65                  70                  75                  80  


Thr His Tyr Glu Lys His Cys Pro Pro Thr Pro Glu Thr Ser Cys Gly 
                85                  90                  95      


Thr Gln Phe Ile Ser Phe Lys Asn Phe Lys Glu Asp Leu Lys Glu Phe 
            100                 105                 110         


Leu Phe Ile Ile Pro Phe Asp Cys Trp Glu Pro Ala Gln Lys Gly Ser 
        115                 120                 125             


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
    130                 135                 140                 


Leu Ala Gly Ser Gly Ala Pro Thr Arg Pro Pro Asn Thr Ala Thr Arg 
145                 150                 155                 160 


Pro Trp Gln His Val Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu Asn 
                165                 170                 175     


His Ser Ser Asp Thr Asp Ala Val Met Asn Asp Thr Glu Val Val Ser 
            180                 185                 190         


Glu Lys Phe Asp Ser Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Lys 
        195                 200                 205             


Leu Tyr Lys Asn Gly Leu Gln Gly Ser Leu Thr Ser Leu Met Gly Ser 
    210                 215                 220                 


Leu Thr Met Met Ala Thr His Tyr Glu Lys His Cys Pro Pro Thr Pro 
225                 230                 235                 240 


Glu Thr Ser Cys Gly Thr Gln Phe Ile Ser Phe Lys Asn Phe Lys Glu 
                245                 250                 255     


Asp Leu Lys Glu Phe Leu Phe Ile Ile Pro Phe Asp Cys Trp Glu Pro 
            260                 265                 270         


Ala Gln Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
        275                 280                 285             


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
    290                 295                 300                 


Ala Pro Thr Arg Pro Pro Asn Thr Ala Thr Arg Pro Trp Gln His Val 
305                 310                 315                 320 


Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu Asn His Ser Ser Asp Thr 
                325                 330                 335     


Asp Ala Val Met Asn Asp Thr Glu Val Val Ser Glu Lys Phe Asp Ser 
            340                 345                 350         


Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Lys Leu Tyr Lys Asn Gly 
        355                 360                 365             


Leu Gln Gly Ser Leu Thr Ser Leu Met Gly Ser Leu Thr Met Met Ala 
    370                 375                 380                 


Thr His Tyr Glu Lys His Cys Pro Pro Thr Pro Glu Thr Ser Cys Gly 
385                 390                 395                 400 


Thr Gln Phe Ile Ser Phe Lys Asn Phe Lys Glu Asp Leu Lys Glu Phe 
                405                 410                 415     


Leu Phe Ile Ile Pro Phe Asp Cys Trp Glu Pro Ala Gln Lys Ala Gly 
            420                 425                 430         


Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
        435                 440                 445             


Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
    450                 455                 460                 


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
465                 470                 475                 480 


<210>  325
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of canine Granulocyte-macrophage 
       colony-stimulating factor polyprotein.

<400>  325

Ala Pro Thr Arg Ser Pro Thr Leu Val Thr Arg Pro Ser Gln His Val 
1               5                   10                  15      


Asp Ala Ile Gln Glu Ala Leu Ser Leu Leu Asn Asn Ser Asn Asp Val 
            20                  25                  30          


Thr Ala Val Met Asn Lys Ala Val Lys Val Val Ser Glu Val Phe Asp 
        35                  40                  45              


Pro Glu Gly Pro Thr Cys Leu Glu Thr Arg Leu Gln Leu Tyr Lys Glu 
    50                  55                  60                  


Gly Leu Gln Gly Ser Leu Thr Ser Leu Lys Asn Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Asn His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Ser Pro Cys 
                85                  90                  95      


Ala Thr Gln Asn Ile Asn Phe Lys Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp Lys Pro Val Lys Lys Gly 
        115                 120                 125             


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
    130                 135                 140                 


Glu Leu Ala Gly Ser Gly Ala Pro Thr Arg Ser Pro Thr Leu Val Thr 
145                 150                 155                 160 


Arg Pro Ser Gln His Val Asp Ala Ile Gln Glu Ala Leu Ser Leu Leu 
                165                 170                 175     


Asn Asn Ser Asn Asp Val Thr Ala Val Met Asn Lys Ala Val Lys Val 
            180                 185                 190         


Val Ser Glu Val Phe Asp Pro Glu Gly Pro Thr Cys Leu Glu Thr Arg 
        195                 200                 205             


Leu Gln Leu Tyr Lys Glu Gly Leu Gln Gly Ser Leu Thr Ser Leu Lys 
    210                 215                 220                 


Asn Pro Leu Thr Met Met Ala Asn His Tyr Lys Gln His Cys Pro Pro 
225                 230                 235                 240 


Thr Pro Glu Ser Pro Cys Ala Thr Gln Asn Ile Asn Phe Lys Ser Phe 
                245                 250                 255     


Lys Glu Asn Leu Lys Asp Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp 
            260                 265                 270         


Lys Pro Val Lys Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
        275                 280                 285             


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
    290                 295                 300                 


Gly Ser Ala Pro Thr Arg Ser Pro Thr Leu Val Thr Arg Pro Ser Gln 
305                 310                 315                 320 


His Val Asp Ala Ile Gln Glu Ala Leu Ser Leu Leu Asn Asn Ser Asn 
                325                 330                 335     


Asp Val Thr Ala Val Met Asn Lys Ala Val Lys Val Val Ser Glu Val 
            340                 345                 350         


Phe Asp Pro Glu Gly Pro Thr Cys Leu Glu Thr Arg Leu Gln Leu Tyr 
        355                 360                 365             


Lys Glu Gly Leu Gln Gly Ser Leu Thr Ser Leu Lys Asn Pro Leu Thr 
    370                 375                 380                 


Met Met Ala Asn His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Ser 
385                 390                 395                 400 


Pro Cys Ala Thr Gln Asn Ile Asn Phe Lys Ser Phe Lys Glu Asn Leu 
                405                 410                 415     


Lys Asp Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp Lys Pro Val Lys 
            420                 425                 430         


Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
        435                 440                 445             


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
    450                 455                 460                 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
465                 470                 475                 480 


His His His 
            


<210>  326
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of feline Granulocyte-macrophage 
       colony-stimulating factor polyprotein.

<400>  326

Ala Pro Thr Ser Ser Pro Ser Ser Val Thr Arg Pro Trp Gln His Val 
1               5                   10                  15      


Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu Asn Asn Ser Ser Glu Ile 
            20                  25                  30          


Thr Ala Val Met Asn Glu Ala Val Glu Val Val Ser Glu Met Phe Asp 
        35                  40                  45              


Pro Glu Glu Pro Lys Cys Met Gln Thr His Leu Lys Leu Tyr Glu Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Ile Ser Leu Lys Glu Pro Leu Arg Met Met 
65                  70                  75                  80  


Ala Asn His Tyr Lys Gln His Cys Pro Leu Thr Pro Glu Thr Pro Cys 
                85                  90                  95      


Glu Thr Gln Thr Ile Thr Phe Lys Asn Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp Glu Pro Asp Gln Lys Gly 
        115                 120                 125             


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
    130                 135                 140                 


Glu Leu Ala Gly Ser Gly Ala Pro Thr Ser Ser Pro Ser Ser Val Thr 
145                 150                 155                 160 


Arg Pro Trp Gln His Val Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu 
                165                 170                 175     


Asn Asn Ser Ser Glu Ile Thr Ala Val Met Asn Glu Ala Val Glu Val 
            180                 185                 190         


Val Ser Glu Met Phe Asp Pro Glu Glu Pro Lys Cys Met Gln Thr His 
        195                 200                 205             


Leu Lys Leu Tyr Glu Gln Gly Leu Arg Gly Ser Leu Ile Ser Leu Lys 
    210                 215                 220                 


Glu Pro Leu Arg Met Met Ala Asn His Tyr Lys Gln His Cys Pro Leu 
225                 230                 235                 240 


Thr Pro Glu Thr Pro Cys Glu Thr Gln Thr Ile Thr Phe Lys Asn Phe 
                245                 250                 255     


Lys Glu Asn Leu Lys Asp Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp 
            260                 265                 270         


Glu Pro Asp Gln Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
        275                 280                 285             


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
    290                 295                 300                 


Gly Ser Ala Pro Thr Ser Ser Pro Ser Ser Val Thr Arg Pro Trp Gln 
305                 310                 315                 320 


His Val Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu Asn Asn Ser Ser 
                325                 330                 335     


Glu Ile Thr Ala Val Met Asn Glu Ala Val Glu Val Val Ser Glu Met 
            340                 345                 350         


Phe Asp Pro Glu Glu Pro Lys Cys Met Gln Thr His Leu Lys Leu Tyr 
        355                 360                 365             


Glu Gln Gly Leu Arg Gly Ser Leu Ile Ser Leu Lys Glu Pro Leu Arg 
    370                 375                 380                 


Met Met Ala Asn His Tyr Lys Gln His Cys Pro Leu Thr Pro Glu Thr 
385                 390                 395                 400 


Pro Cys Glu Thr Gln Thr Ile Thr Phe Lys Asn Phe Lys Glu Asn Leu 
                405                 410                 415     


Lys Asp Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp Glu Pro Asp Gln 
            420                 425                 430         


Lys Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
        435                 440                 445             


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
    450                 455                 460                 


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
465                 470                 475                 480 


His His His 
            


<210>  327
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of bovine Granulocyte 
       colony-stimulating factor polyprotein.

<400>  327

Thr Pro Leu Gly Pro Ala Arg Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Ile Gln Ala Asp Gly Ala Glu Leu Gln 
            20                  25                  30          


Glu Arg Leu Cys Ala Ala His Lys Leu Cys His Pro Glu Glu Leu Met 
        35                  40                  45              


Leu Leu Arg His Ser Leu Gly Ile Pro Gln Ala Pro Leu Ser Ser Cys 
    50                  55                  60                  


Ser Ser Gln Ser Leu Gln Leu Thr Ser Cys Leu Asn Gln Leu His Gly 
65                  70                  75                  80  


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ala Gly Ile Ser 
                85                  90                  95      


Pro Glu Leu Ala Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Thr Asp 
            100                 105                 110         


Phe Ala Thr Asn Ile Trp Leu Gln Met Glu Asp Leu Gly Ala Ala Pro 
        115                 120                 125             


Ala Val Gln Pro Thr Gln Gly Ala Met Pro Thr Phe Thr Ser Ala Phe 
    130                 135                 140                 


Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser Gln Leu His Arg Phe 
145                 150                 155                 160 


Leu Glu Leu Ala Tyr Arg Gly Leu Arg Tyr Leu Ala Glu Pro Gly Ser 
                165                 170                 175     


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
            180                 185                 190         


Leu Ala Gly Ser Gly Thr Pro Leu Gly Pro Ala Arg Ser Leu Pro Gln 
        195                 200                 205             


Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Ala Asp 
    210                 215                 220                 


Gly Ala Glu Leu Gln Glu Arg Leu Cys Ala Ala His Lys Leu Cys His 
225                 230                 235                 240 


Pro Glu Glu Leu Met Leu Leu Arg His Ser Leu Gly Ile Pro Gln Ala 
                245                 250                 255     


Pro Leu Ser Ser Cys Ser Ser Gln Ser Leu Gln Leu Thr Ser Cys Leu 
            260                 265                 270         


Asn Gln Leu His Gly Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 
        275                 280                 285             


Leu Ala Gly Ile Ser Pro Glu Leu Ala Pro Thr Leu Asp Thr Leu Gln 
    290                 295                 300                 


Leu Asp Val Thr Asp Phe Ala Thr Asn Ile Trp Leu Gln Met Glu Asp 
305                 310                 315                 320 


Leu Gly Ala Ala Pro Ala Val Gln Pro Thr Gln Gly Ala Met Pro Thr 
                325                 330                 335     


Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 
            340                 345                 350         


Gln Leu His Arg Phe Leu Glu Leu Ala Tyr Arg Gly Leu Arg Tyr Leu 
        355                 360                 365             


Ala Glu Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
    370                 375                 380                 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Pro Ala Arg Ser Leu Pro Gln Ser Phe Leu Leu Lys 
                405                 410                 415     


Cys Leu Glu Gln Val Arg Lys Ile Gln Ala Asp Gly Ala Glu Leu Gln 
            420                 425                 430         


Glu Arg Leu Cys Ala Ala His Lys Leu Cys His Pro Glu Glu Leu Met 
        435                 440                 445             


Leu Leu Arg His Ser Leu Gly Ile Pro Gln Ala Pro Leu Ser Ser Cys 
    450                 455                 460                 


Ser Ser Gln Ser Leu Gln Leu Thr Ser Cys Leu Asn Gln Leu His Gly 
465                 470                 475                 480 


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ala Gly Ile Ser 
                485                 490                 495     


Pro Glu Leu Ala Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Thr Asp 
            500                 505                 510         


Phe Ala Thr Asn Ile Trp Leu Gln Met Glu Asp Leu Gly Ala Ala Pro 
        515                 520                 525             


Ala Val Gln Pro Thr Gln Gly Ala Met Pro Thr Phe Thr Ser Ala Phe 
    530                 535                 540                 


Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser Gln Leu His Arg Phe 
545                 550                 555                 560 


Leu Glu Leu Ala Tyr Arg Gly Leu Arg Tyr Leu Ala Glu Pro Ala Gly 
                565                 570                 575     


Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
            580                 585                 590         


Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
        595                 600                 605             


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
    610                 615                 620                 


<210>  328
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of canine Granulocyte 
       colony-stimulating factor polyprotein.

<400>  328

Met Ala Pro Leu Gly Pro Thr Gly Pro Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Met Arg Lys Val Gln Ala Asp Gly Thr Ala Leu 
            20                  25                  30          


Gln Glu Thr Leu Cys Ala Thr His Gln Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ala Leu Gly Ile Pro Gln Pro Pro Leu Ser Ser 
    50                  55                  60                  


Cys Ser Ser Gln Ala Leu Gln Leu Met Gly Cys Leu Arg Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ala Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Ala Pro Thr Leu Asp Thr Leu Gln Leu Asp Thr Thr 
            100                 105                 110         


Asp Phe Ala Ile Asn Ile Trp Gln Gln Met Glu Asp Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Val Pro Pro Thr Gln Gly Thr Met Pro Ala Phe Thr Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser Asn Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Leu Ala Tyr Arg Ala Leu Arg His Phe Ala Lys Pro Gly 
                165                 170                 175     


Ser Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
            180                 185                 190         


Glu Leu Ala Gly Ser Gly Met Ala Pro Leu Gly Pro Thr Gly Pro Leu 
        195                 200                 205             


Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Met Arg Lys Val Gln 
    210                 215                 220                 


Ala Asp Gly Thr Ala Leu Gln Glu Thr Leu Cys Ala Thr His Gln Leu 
225                 230                 235                 240 


Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ala Leu Gly Ile Pro 
                245                 250                 255     


Gln Pro Pro Leu Ser Ser Cys Ser Ser Gln Ala Leu Gln Leu Met Gly 
            260                 265                 270         


Cys Leu Arg Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu 
        275                 280                 285             


Gln Ala Leu Ala Gly Ile Ser Pro Glu Leu Ala Pro Thr Leu Asp Thr 
    290                 295                 300                 


Leu Gln Leu Asp Thr Thr Asp Phe Ala Ile Asn Ile Trp Gln Gln Met 
305                 310                 315                 320 


Glu Asp Leu Gly Met Ala Pro Ala Val Pro Pro Thr Gln Gly Thr Met 
                325                 330                 335     


Pro Ala Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val 
            340                 345                 350         


Ala Ser Asn Leu Gln Ser Phe Leu Glu Leu Ala Tyr Arg Ala Leu Arg 
        355                 360                 365             


His Phe Ala Lys Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser 
    370                 375                 380                 


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly 
385                 390                 395                 400 


Gly Ser Met Ala Pro Leu Gly Pro Thr Gly Pro Leu Pro Gln Ser Phe 
                405                 410                 415     


Leu Leu Lys Cys Leu Glu Gln Met Arg Lys Val Gln Ala Asp Gly Thr 
            420                 425                 430         


Ala Leu Gln Glu Thr Leu Cys Ala Thr His Gln Leu Cys His Pro Glu 
        435                 440                 445             


Glu Leu Val Leu Leu Gly His Ala Leu Gly Ile Pro Gln Pro Pro Leu 
    450                 455                 460                 


Ser Ser Cys Ser Ser Gln Ala Leu Gln Leu Met Gly Cys Leu Arg Gln 
465                 470                 475                 480 


Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ala 
                485                 490                 495     


Gly Ile Ser Pro Glu Leu Ala Pro Thr Leu Asp Thr Leu Gln Leu Asp 
            500                 505                 510         


Thr Thr Asp Phe Ala Ile Asn Ile Trp Gln Gln Met Glu Asp Leu Gly 
        515                 520                 525             


Met Ala Pro Ala Val Pro Pro Thr Gln Gly Thr Met Pro Ala Phe Thr 
    530                 535                 540                 


Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser Asn Leu 
545                 550                 555                 560 


Gln Ser Phe Leu Glu Leu Ala Tyr Arg Ala Leu Arg His Phe Ala Lys 
                565                 570                 575     


Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg 
            580                 585                 590         


Val Pro Lys Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr 
        595                 600                 605             


Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His 
    610                 615                 620                 


His His His 
625         


<210>  329
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  This is the amino acid sequence of feline Granulocyte 
       colony-stimulating factor polyprotein.

<400>  329

Thr Pro Leu Gly Pro Thr Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Val Gln Ala Asp Gly Thr Ala Leu Gln 
            20                  25                  30          


Glu Arg Leu Cys Ala Ala His Lys Leu Cys His Pro Glu Glu Leu Val 
        35                  40                  45              


Leu Leu Gly His Ala Leu Gly Ile Pro Gln Ala Pro Leu Ser Ser Cys 
    50                  55                  60                  


Ser Ser Gln Ala Leu Gln Leu Thr Gly Cys Leu Arg Gln Leu His Ser 
65                  70                  75                  80  


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ala Gly Ile Ser 
                85                  90                  95      


Pro Glu Leu Ala Pro Thr Leu Asp Met Leu Gln Leu Asp Ile Thr Asp 
            100                 105                 110         


Phe Ala Ile Asn Ile Trp Gln Gln Met Glu Asp Val Gly Met Ala Pro 
        115                 120                 125             


Ala Val Pro Pro Thr Gln Gly Thr Met Pro Thr Phe Thr Ser Ala Phe 
    130                 135                 140                 


Gln Arg Arg Ala Gly Gly Thr Leu Val Ala Ser Asn Leu Gln Ser Phe 
145                 150                 155                 160 


Leu Glu Val Ala Tyr Arg Ala Leu Arg His Phe Thr Lys Pro Gly Ser 
                165                 170                 175     


Gly Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
            180                 185                 190         


Leu Ala Gly Ser Gly Thr Pro Leu Gly Pro Thr Ser Ser Leu Pro Gln 
        195                 200                 205             


Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Val Gln Ala Asp 
    210                 215                 220                 


Gly Thr Ala Leu Gln Glu Arg Leu Cys Ala Ala His Lys Leu Cys His 
225                 230                 235                 240 


Pro Glu Glu Leu Val Leu Leu Gly His Ala Leu Gly Ile Pro Gln Ala 
                245                 250                 255     


Pro Leu Ser Ser Cys Ser Ser Gln Ala Leu Gln Leu Thr Gly Cys Leu 
            260                 265                 270         


Arg Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 
        275                 280                 285             


Leu Ala Gly Ile Ser Pro Glu Leu Ala Pro Thr Leu Asp Met Leu Gln 
    290                 295                 300                 


Leu Asp Ile Thr Asp Phe Ala Ile Asn Ile Trp Gln Gln Met Glu Asp 
305                 310                 315                 320 


Val Gly Met Ala Pro Ala Val Pro Pro Thr Gln Gly Thr Met Pro Thr 
                325                 330                 335     


Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Thr Leu Val Ala Ser 
            340                 345                 350         


Asn Leu Gln Ser Phe Leu Glu Val Ala Tyr Arg Ala Leu Arg His Phe 
        355                 360                 365             


Thr Lys Pro Ala Gly Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp 
    370                 375                 380                 


Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Ser Gly Gly Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Pro Thr Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
                405                 410                 415     


Cys Leu Glu Gln Val Arg Lys Val Gln Ala Asp Gly Thr Ala Leu Gln 
            420                 425                 430         


Glu Arg Leu Cys Ala Ala His Lys Leu Cys His Pro Glu Glu Leu Val 
        435                 440                 445             


Leu Leu Gly His Ala Leu Gly Ile Pro Gln Ala Pro Leu Ser Ser Cys 
    450                 455                 460                 


Ser Ser Gln Ala Leu Gln Leu Thr Gly Cys Leu Arg Gln Leu His Ser 
465                 470                 475                 480 


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ala Gly Ile Ser 
                485                 490                 495     


Pro Glu Leu Ala Pro Thr Leu Asp Met Leu Gln Leu Asp Ile Thr Asp 
            500                 505                 510         


Phe Ala Ile Asn Ile Trp Gln Gln Met Glu Asp Val Gly Met Ala Pro 
        515                 520                 525             


Ala Val Pro Pro Thr Gln Gly Thr Met Pro Thr Phe Thr Ser Ala Phe 
    530                 535                 540                 


Gln Arg Arg Ala Gly Gly Thr Leu Val Ala Ser Asn Leu Gln Ser Phe 
545                 550                 555                 560 


Leu Glu Val Ala Tyr Arg Ala Leu Arg His Phe Thr Lys Pro Ala Gly 
                565                 570                 575     


Ser Gly Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
            580                 585                 590         


Val Ser Ala Ser His Leu Glu Gly Ser Gly Gly Gln Tyr Ile Lys Ala 
        595                 600                 605             


Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu His His His His His His 
    610                 615                 620                 


