               SEQUENCE LISTING

<110> Thelper AS

<120> Therapeutic and Diagnostic Agents and Uses Thereof

<130> THEBE/P78812PC

<150> GB2101228.1
<151> 2021-01-29

<160> 178

<170> BiSSAP 1.3.6

<210> 1
<211> 37
<212> PRT
<213> Artificial Sequence


<220> 
<223> ECD1 of US28, HCMV strain DB

<400> 1
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Ala Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu 
        35          

<210> 2
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ECD2 of US28, HCMV strain DB

<400> 2
Gln Tyr Leu Leu Asp His Asn Ser Leu Ala Ser 
1               5                   10      

<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ECD3 of US28, HCMV strain DB

<400> 3
Thr Lys Lys Asn Asn Gln Cys Met Thr Asp Tyr Asp Tyr Leu Glu Val 
1               5                   10                  15      
Ser 
    

<210> 4
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> ECD4 of US28, HCMV strain DB

<400> 4
Val Asp Thr Leu Lys Leu Leu Lys Trp Ile Ser Ser Ser Cys Glu Phe 
1               5                   10                  15      
Glu Arg Ser Leu Lys Arg Ala Leu 
            20                  

<210> 5
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28, HCMV strain DB

<400> 5
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Ala Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asn Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ECD3 4N variant group of HCMV strains

<400> 6
Thr Lys Lys Asn Asn Gln Cys Met Thr Asp Tyr Asp Tyr Leu Glu Val 
1               5                   10                  15      
Ser 
    

<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ECD3 4D variant group of HCMV strains

<400> 7
Thr Lys Lys Asp Asn Gln Cys Met Thr Asp Tyr Asp Tyr Leu Glu Val 
1               5                   10                  15      
Ser 
    

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1 sequence of 1D3

<400> 8
Gly Phe Thr Phe Thr Asp Tyr Tyr 
1               5               

<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2 sequence of 1D3

<400> 9
Ile Arg Ser Lys Ala Asn Gly Tyr Thr Thr 
1               5                   10  

<210> 10
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3 sequence of 1D3

<400> 10
Ala Arg Asp Glu Arg Arg Thr Ala Trp Leu Ala Tyr 
1               5                   10          

<210> 11
<211> 140
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1D3,
      wherein positions 1-19 correspond to a leader sequence

<400> 11
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ala Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              
Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
    50                  55                  60                  
Glu Trp Leu Gly Phe Ile Arg Ser Lys Ala Asn Gly Tyr Thr Thr Glu 
65                  70                  75                  80  
Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      
Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ser Glu Asp Ser 
            100                 105                 110         
Ala Thr Tyr Tyr Cys Ala Arg Asp Glu Arg Arg Thr Ala Trp Leu Ala 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140 

<210> 12
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1D3, without the leader sequence

<400> 12
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ala Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Thr Leu Arg Ser Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Asp Glu Arg Arg Thr Ala Trp Leu Ala Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     

<210> 13
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Leader sequence of recombinantly expressed VH sequence of 1D3

<400> 13
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys 
            

<210> 14
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1 sequence of 1D3

<400> 14
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      

<210> 15
<400> 15
000

<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3 sequence of 1D3

<400> 16
Phe Gln Gly Ser His Val Pro Thr Trp Thr 
1               5                   10  

<210> 17
<211> 132
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1D3,
      wherein positions 1-19 correspond to a leader sequence

<400> 17
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          
Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              
Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  
Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         
Phe Gln Gly Ser His Val Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             
Leu Glu Ile Lys 
    130         

<210> 18
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1D3, without the leader sequence

<400> 18
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 19
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Leader sequence of recombinantly expressed VL sequence of 1D3

<400> 19
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser 
            

<210> 20
<211> 464
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1D3

<400> 20
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ala Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              
Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
    50                  55                  60                  
Glu Trp Leu Gly Phe Ile Arg Ser Lys Ala Asn Gly Tyr Thr Thr Glu 
65                  70                  75                  80  
Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      
Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ser Glu Asp Ser 
            100                 105                 110         
Ala Thr Tyr Tyr Cys Ala Arg Asp Glu Arg Arg Thr Ala Trp Leu Ala 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr 
    130                 135                 140                 
Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 
Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     
Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             
Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 
Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 
Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     
Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         
Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             
Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 
Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 
Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     
Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         
Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             
Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 
Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 
Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     
Thr Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         
Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             
Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 



<210> 21
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1D3

<400> 21
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          
Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              
Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  
Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         
Phe Gln Gly Ser His Val Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             
Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 
Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 
Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     
Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         
Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             
Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 
Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 

<210> 22
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR1 sequence of 1D3

<400> 22
gggttcacct tcactgatta ctat                                           24


<210> 23
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR2 sequence of 1D3

<400> 23
attagaagca aagctaatgg ttacacaaca                                     30


<210> 24
<211> 36
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR3 sequence of 1D3

<400> 24
gcaagagatg agcgccgtac tgcctggctt gcttac                               36


<210> 25
<211> 422
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1D3

<400> 25
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgag      60

gtgaagctgg tggagtctgg aggaggcttg gtacagccgg ggggttctct gagactcgcc     120

tgtgcaactt ctgggttcac cttcactgat tactatatga gctgggtccg ccagcctcca     180

ggaaaggcac ttgagtggct gggttttatt agaagcaaag ctaatggtta cacaacagag     240

tacagtgcat ctgttaaggg tcggttcacc atctccagag ataattccca aagcatcctc     300

tatcttcaaa tgaacaccct gagatctgag gacagtgcca cttattactg tgcaagagat     360

gagcgccgta ctgcctggct tgcttactgg ggccaaggga ctctggtcac tgtctctgca     420

gc                                                                    422


<210> 26
<211> 365
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1D3

<400> 26
gaggtgaagc tggtggagtc tggaggaggc ttggtacagc cggggggttc tctgagactc      60

gcctgtgcaa cttctgggtt caccttcact gattactata tgagctgggt ccgccagcct     120

ccaggaaagg cacttgagtg gctgggtttt attagaagca aagctaatgg ttacacaaca     180

gagtacagtg catctgttaa gggtcggttc accatctcca gagataattc ccaaagcatc     240

ctctatcttc aaatgaacac cctgagatct gaggacagtg ccacttatta ctgtgcaaga     300

gatgagcgcc gtactgcctg gcttgcttac tggggccaag ggactctggt cactgtctct     360

gcagc                                                                 365


<210> 27
<211> 57
<212> DNA
<213> Artificial Sequence


<220> 
<223> Leader sequence of recombinantly expressed VH sequence of 1D3

<400> 27
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgt        57


<210> 28
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL-CDR1 sequence of 1D3

<400> 28
cagagcattg tacatagtaa tggaaacacc tat                                  33


<210> 29
<400> 29
000

<210> 30
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL-CDR3 sequence of 1D3

<400> 30
tttcaaggtt cacatgttcc cacgtggacg                                     30


<210> 31
<211> 396
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1D3

<400> 31
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtgat      60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc     120

tcttgcagat ctagtcagag cattgtacat agtaatggaa acacctattt agactggtac     180

cttcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct     240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caaaatcagc     300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttcccacg     360

tggacgttcg gtggaggcac caagctggaa atcaaa                               396


<210> 32
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1D3

<400> 32
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagactgg     120

taccttcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaaaatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccc     300

acgtggacgt tcggtggagg caccaagctg gaaatcaaa                            339


<210> 33
<211> 57
<212> DNA
<213> Artificial Sequence


<220> 
<223> Leader sequence of recombinantly expressed VL sequence of 1D3

<400> 33
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagt        57


<210> 34
<211> 1395
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1D3

<400> 34
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgag      60

gtgaagctgg tggagtctgg aggaggcttg gtacagccgg ggggttctct gagactcgcc     120

tgtgcaactt ctgggttcac cttcactgat tactatatga gctgggtccg ccagcctcca     180

ggaaaggcac ttgagtggct gggttttatt agaagcaaag ctaatggtta cacaacagag     240

tacagtgcat ctgttaaggg tcggttcacc atctccagag ataattccca aagcatcctc     300

tatcttcaaa tgaacaccct gagatctgag gacagtgcca cttattactg tgcaagagat     360

gagcgccgta ctgcctggct tgcttactgg ggccaaggga ctctggtcac tgtctctgca     420

gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac     480

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc     540

tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac     600

ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc     660

acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg     720

gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc     780

cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg     840

gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag     900

gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc     960

agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc    1020

aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg    1080

aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc    1140

agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg    1200

aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct    1260

tacttcatct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc    1320

acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac    1380

tctcctggta aatga                                                     1395


<210> 35
<211> 720
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1D3

<400> 35
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtgat      60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc     120

tcttgcagat ctagtcagag cattgtacat agtaatggaa acacctattt agactggtac     180

cttcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct     240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caaaatcagc     300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttcccacg     360

tggacgttcg gtggaggcac caagctggaa atcaaacggg ctgatgctgc accaactgta     420

tccatcttcc caccatccag tgagcagtta acatctggag gtgcctcagt cgtgtgcttc     480

ttgaacaact tctaccccaa agacatcaat gtcaagtgga agattgatgg cagtgaacga     540

caaaatggcg tcctgaacag ttggactgat caggacagca aagacagcac ctacagcatg     600

agcagcaccc tcacgttgac caaggacgag tatgaacgac ataacagcta tacctgtgag     660

gccactcaca agacatcaac ttcacccatt gtcaagagct tcaacaggaa tgagtgttag     720


<210> 36
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 Toledo strain

<400> 36
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Ala Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asn Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 37
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 Towne strain

<400> 37
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Asp Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 38
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 VR 1814 strain

<400> 38
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Asp Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Gly Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 39
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 TB40/E strain

<400> 39
Met Thr Pro Thr Thr Thr Thr Thr Glu Leu Thr Thr Glu Phe Glu Tyr 
1               5                   10                  15      
Asp Leu Gly Ala Thr Pro Cys Thr Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Val Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 40
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 Merlin strain

<400> 40
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Asp Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Gly Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 41
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 JP strain

<400> 41
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Ala Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 42
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 Ad169 strain

<400> 42
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Asp Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 43
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 AF1 strain

<400> 43
Met Thr Pro Pro Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Ala Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 44
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 VHL/E strain

<400> 44
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Asp Glu Ala Thr Pro Cys Val Leu Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Lys Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Ala Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 45
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 DAVIS strain

<400> 45
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Asp Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Ile Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Lys Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Ala Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 46
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 TR strain

<400> 46
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Ala Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Ile Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asn Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Lys Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 47
<211> 367
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 fusion protein, comprising US28 sequence from HCMV DB strain

<400> 47
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Ala Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asn Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro Ala Ala Ala Leu Glu Gly Ser His His His His His His 
        355                 360                 365         

<210> 48
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> OKT3 heavy chain variable region

<400> 48
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser 
        115                 

<210> 49
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> OKT3 VH-CDR1 sequence

<400> 49
Arg Tyr Thr Met His 
1               5   

<210> 50
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> OKT3 VH-CDR2 sequence

<400> 50
Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      



<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> OKT3 VH-CDR3 sequence

<400> 51
Tyr Cys Ala Arg Tyr Tyr Asp Asp 
1               5               

<210> 52
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> OKT3 light chain variable region

<400> 52
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      
Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            100                 105     

<210> 53
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> OKT3 VL-CDR1 sequence

<400> 53
Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
1               5                   10      

<210> 54
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> OKT3 VL-CDR2 sequence

<400> 54
Thr Ser Lys Leu Ala Ser Gly 
1               5           

<210> 55
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> OKT3 VL-CDR3 sequence

<400> 55
Gln Trp Ser Ser Asn Pro Phe Thr Phe 
1               5                   

<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker sequence

<400> 56
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 57
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Partial linker sequence

<400> 57
Gly Gly Gly Gly Ser 
1               5   

<210> 58
<211> 701
<212> PRT
<213> Artificial Sequence


<220> 
<223> BiTE molecule comprising a heavy chain sequence that includes the
      VH region of 1D3, a linker sequence, and the sequence of an OKT3
      scFv

<400> 58
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ala Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Thr Leu Arg Ser Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Asp Glu Arg Arg Thr Ala Trp Leu Ala Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
    450                 455                 460                 
Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys 
465                 470                 475                 480 
Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
                485                 490                 495     
Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
            500                 505                 510         
Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys 
        515                 520                 525             
Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
    530                 535                 540                 
Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr 
545                 550                 555                 560 
Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                565                 570                 575     
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         
Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
        595                 600                 605             
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
    610                 615                 620                 
Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
625                 630                 635                 640 
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe 
                645                 650                 655     
Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met 
            660                 665                 670         
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
        675                 680                 685             
Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
    690                 695                 700     

<210> 59
<211> 220
<212> PRT
<213> Artificial Sequence


<220> 
<223> BiTE molecule comprising a light chain sequence that includes the
      VL region of 1D3

<400> 59
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 60
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> Core sequence of VUN100

<400> 60
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ala Cys Ala Val Ser Gly Pro Gly Leu Ile Phe Lys 
            20                  25                  30          
Phe Thr Gly Val Ala Trp Tyr Arg Arg Gln Val Pro Gly Ala Lys Arg 
        35                  40                  45              
Gly Leu Val Ala Leu Ile Thr Gly Asp Gly Ala Thr Arg Tyr Gly Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Ala Lys Arg 
65                  70                  75                  80  
Val Tyr Leu Glu Met Asn Asp Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Lys Thr Gly Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 61
<211> 148
<212> PRT
<213> Artificial Sequence


<220> 
<223> VUN100 sequence with additional N-terminal signal peptide, and
      C-terminal Myc-6His tag

<400> 61
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      
Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          
Gly Gly Ser Leu Arg Leu Ala Cys Ala Val Ser Gly Pro Gly Leu Ile 
        35                  40                  45              
Phe Lys Phe Thr Gly Val Ala Trp Tyr Arg Arg Gln Val Pro Gly Ala 
    50                  55                  60                  
Lys Arg Gly Leu Val Ala Leu Ile Thr Gly Asp Gly Ala Thr Arg Tyr 
65                  70                  75                  80  
Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Ala 
                85                  90                  95      
Lys Arg Val Tyr Leu Glu Met Asn Asp Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Lys Thr Gly Glu Tyr Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             
Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His His 
    130                 135                 140                 
His His His His 
145             

<210> 62
<211> 258
<212> PRT
<213> Artificial Sequence


<220> 
<223> VUN100b

<400> 62
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ala Cys Ala Val Ser Gly Pro Gly Leu Ile Phe Lys 
            20                  25                  30          
Phe Thr Gly Val Ala Trp Tyr Arg Arg Gln Val Pro Gly Ala Lys Arg 
        35                  40                  45              
Gly Leu Val Ala Leu Ile Thr Gly Asp Gly Ala Thr Arg Tyr Gly Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Ala Lys Arg 
65                  70                  75                  80  
Val Tyr Leu Glu Met Asn Asp Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Lys Thr Gly Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 
Ser Leu Arg Leu Ala Cys Ala Val Ser Gly Pro Gly Leu Ile Phe Lys 
                165                 170                 175     
Phe Thr Gly Val Ala Trp Tyr Arg Arg Gln Val Pro Gly Ala Lys Arg 
            180                 185                 190         
Gly Leu Val Ala Leu Ile Thr Gly Asp Gly Ala Thr Arg Tyr Gly Asp 
        195                 200                 205             
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Ala Lys Arg 
    210                 215                 220                 
Val Tyr Leu Glu Met Asn Asp Leu Arg Ser Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 
Tyr Cys Lys Thr Gly Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                245                 250                 255     
Ser Ser 
        

<210> 63
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> VUN100b with additional N-terminal signal peptide, and C-terminal
      Myc-6His tag

<400> 63
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      
Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          
Gly Gly Ser Leu Arg Leu Ala Cys Ala Val Ser Gly Pro Gly Leu Ile 
        35                  40                  45              
Phe Lys Phe Thr Gly Val Ala Trp Tyr Arg Arg Gln Val Pro Gly Ala 
    50                  55                  60                  
Lys Arg Gly Leu Val Ala Leu Ile Thr Gly Asp Gly Ala Thr Arg Tyr 
65                  70                  75                  80  
Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Ala 
                85                  90                  95      
Lys Arg Val Tyr Leu Glu Met Asn Asp Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Lys Thr Gly Glu Tyr Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 
Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                165                 170                 175     
Gly Gly Ser Leu Arg Leu Ala Cys Ala Val Ser Gly Pro Gly Leu Ile 
            180                 185                 190         
Phe Lys Phe Thr Gly Val Ala Trp Tyr Arg Arg Gln Val Pro Gly Ala 
        195                 200                 205             
Lys Arg Gly Leu Val Ala Leu Ile Thr Gly Asp Gly Ala Thr Arg Tyr 
    210                 215                 220                 
Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Ile Ala Ala 
225                 230                 235                 240 
Lys Arg Val Tyr Leu Glu Met Asn Asp Leu Arg Ser Glu Asp Thr Ala 
                245                 250                 255     
Val Tyr Tyr Cys Lys Thr Gly Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            260                 265                 270         
Thr Val Ser Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His His 
        275                 280                 285             
His His His His 
    290         

<210> 64
<400> 64
000

<210> 65
<211> 423
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1G9

<400> 65
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgaa      60

gtgaagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc     120

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagactcca     180

gagaagaggc tggagtgggt cgcatccatt agtagtggtg gtagcaccta ctatccagac     240

agtgtgaagg gccgattcac catctccaga gataatgcca ggaacatcct gtacctgcaa     300

atgagcagtc tgaggtctga ggacacggcc atgtattact gtgcaagagg cgggtctact     360

atgattacga cggggctggg gtttgcttac tggggccaag ggactctggt cactgtctct     420

gca                                                                   423


<210> 66
<211> 366
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1G9

<400> 66
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc      60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact     120

ccagagaaga ggctggagtg ggtcgcatcc attagtagtg gtggtagcac ctactatcca     180

gacagtgtga agggccgatt caccatctcc agagataatg ccaggaacat cctgtacctg     240

caaatgagca gtctgaggtc tgaggacacg gccatgtatt actgtgcaag aggcgggtct     300

actatgatta cgacggggct ggggtttgct tactggggcc aagggactct ggtcactgtc     360

tctgca                                                                366


<210> 67
<211> 141
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1G9,
      wherein positions 1-19 correspond to a leader sequence

<400> 67
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile 
                85                  90                  95      
Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Gly Gly Ser Thr Met Ile Thr Thr Gly Leu Gly Phe 
        115                 120                 125             
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140     

<210> 68
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1G9, without the leader sequence

<400> 68
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Gly Ser Thr Met Ile Thr Thr Gly Leu Gly Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         

<210> 69
<211> 378
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1G9

<400> 69
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtcaa      60

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg     120

acctgcagtg ccagctcaag tgtaagttac atgcactggt accagcagaa gtcaggcacc     180

tcccccaaaa gatggattta tgacacatcc aaactggctt ctggagtccc tgctcgcttc     240

agtggcagtg ggtctgggac ctcttactct ctcacaatca gcagcatgga ggctgaagat     300

gctgccactt attactgcca gcagtggagt agtaacccac ccctcacgtt cggtgctggg     360

accaagctgg agctgaaa                                                   378


<210> 70
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1G9

<400> 70
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc      60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cacccctcac gttcggtgct     300

gggaccaagc tggagctgaa a                                               321


<210> 71
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1G9,
      wherein positions 1-19 correspond to a leader sequence

<400> 71
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              
Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    50                  55                  60                  
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
                85                  90                  95      
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
            100                 105                 110         
Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125     

<210> 72
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1G9, without the leader sequence

<400> 72
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 73
<211> 15
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR1 sequence of 1G9, 1E8

<400> 73
agctatgcca tgtct                                                     15


<210> 74
<211> 48
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR2 sequence of 1G9

<400> 74
tccattagta gtggtggtag cacctactat ccagacagtg tgaagggc                  48


<210> 75
<211> 42
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR3 sequence of 1G9

<400> 75
ggcgggtcta ctatgattac gacggggctg gggtttgctt ac                        42


<210> 76
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1 sequence of 1G9, 1E8

<400> 76
Ser Tyr Ala Met Ser 
1               5   

<210> 77
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2 sequence of 1G9

<400> 77
Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 78
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3 sequence of 1G9

<400> 78
Gly Gly Ser Thr Met Ile Thr Thr Gly Leu Gly Phe Ala Tyr 
1               5                   10                  

<210> 79
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL-CDR1 sequence of 1G9, 1E8

<400> 79
agtgccagct caagtgtaag ttacatgcac                                     30


<210> 80
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL-CDR2 sequence of 1G9, 1C10, 1A10

<400> 80
gacacatcca aactggcttc t                                              21


<210> 81
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL-CDR3 sequence of 1G9

<400> 81
cagcagtgga gtagtaaccc acccctcacg                                     30


<210> 82
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1 sequence of 1G9, 1E8

<400> 82
Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  

<210> 83
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2 sequence of 1G9, 1C10, 1A10

<400> 83
Asp Thr Ser Lys Leu Ala Ser 
1               5           

<210> 84
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3 sequence of 1G9

<400> 84
Gln Gln Trp Ser Ser Asn Pro Pro Leu Thr 
1               5                   10  

<210> 85
<211> 420
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1E8

<400> 85
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgaa      60

gtgaagctgg tggagtctgg gggagactta gtgaagcctg gagggtccct gaaactctcc     120

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagactcca     180

gagaagaggc tggagtgggt cgcatccatt agtagtggtg gtagaaccta ctatccagac     240

agtgtgaagg gccgattcac catctccaga gataatgcca ggaacatcct gtacctgcaa     300

atgagcagtc tgaggtctga agacacggcc atctattact gtgcacgagg cgggactcgt     360

cattcctacg gcaacgggtt tgactactgg ggccaaggca ccactctcac agtctcctca     420


<210> 86
<211> 363
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1E8

<400> 86
gaagtgaagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc      60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact     120

ccagagaaga ggctggagtg ggtcgcatcc attagtagtg gtggtagaac ctactatcca     180

gacagtgtga agggccgatt caccatctcc agagataatg ccaggaacat cctgtacctg     240

caaatgagca gtctgaggtc tgaagacacg gccatctatt actgtgcacg aggcgggact     300

cgtcattcct acggcaacgg gtttgactac tggggccaag gcaccactct cacagtctcc     360

tca                                                                   363


<210> 87
<211> 140
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1E8,
      wherein positions 1-19 correspond to a leader sequence

<400> 87
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Ser Ile Ser Ser Gly Gly Arg Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile 
                85                  90                  95      
Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Gly Gly Thr Arg His Ser Tyr Gly Asn Gly Phe Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 

<210> 88
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1E8, without the leader sequence

<400> 88
Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Ser Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Gly Thr Arg His Ser Tyr Gly Asn Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     

<210> 89
<211> 378
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1E8

<400> 89
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtcaa      60

attgttctct cccagtctcc aacaatcatg tctgcatctc caggggagaa ggtcaccatg     120

acctgcagtg ccagctcaag tgtaagttac atgcactggt accagcagaa gtcaggcacc     180

tcccccaaaa gatggattta tgactcatcc aaactggctt ctggagtccc tgctcgcttc     240

agtggcagtg ggtctgggac ctcttactct ctcacaatca gcagcatgga ggctgaagat     300

gctgccactt attactgcca gcagtggact agtaacccac ccatcacgtt cggtgctggg     360

accaagctgg agctgaaa                                                   378


<210> 90
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1E8

<400> 90
caaattgttc tctcccagtc tccaacaatc atgtctgcat ctccagggga gaaggtcacc      60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgactca tccaaactgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg actagtaacc cacccatcac gttcggtgct     300

gggaccaagc tggagctgaa a                                               321


<210> 91
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1E8,
      wherein positions 1-19 correspond to a leader sequence

<400> 91
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Met Ser Ala 
            20                  25                  30          
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              
Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    50                  55                  60                  
Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
                85                  90                  95      
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn 
            100                 105                 110         
Pro Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125     

<210> 92
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1E8, without the leader sequence

<400> 92
Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Ile 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 93
<211> 48
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR2 sequence of 1E8

<400> 93
tccattagta gtggtggtag aacctactat ccagacagtg tgaagggc                  48


<210> 94
<211> 39
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR3 sequence of 1E8

<400> 94
ggcgggactc gtcattccta cggcaacggg tttgactac                            39


<210> 95
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2 sequence of 1E8

<400> 95
Ser Ile Ser Ser Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 96
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3 sequence of 1E8

<400> 96
Gly Gly Thr Arg His Ser Tyr Gly Asn Gly Phe Asp Tyr 
1               5                   10              

<210> 97
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL-CDR2 sequence of 1E8

<400> 97
gactcatcca aactggcttc t                                              21


<210> 98
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL-CDR3 sequence of 1E8

<400> 98
cagcagtgga ctagtaaccc acccatcacg                                     30


<210> 99
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2 sequence of 1E8

<400> 99
Asp Ser Ser Lys Leu Ala Ser 
1               5           

<210> 100
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3 sequence of 1E8

<400> 100
Gln Gln Trp Thr Ser Asn Pro Pro Ile Thr 
1               5                   10  

<210> 101
<211> 420
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1C10

<400> 101
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgaa      60

gtgaaactgg ttgagtctgg gggagtctta gtgaagcctg gagggtccct gaaattttcc     120

tgtgcagcct ctggattcac tttcagtagc catgccttgt cttgggttcg ccagactcca     180

gagaagagac tggagtgggt cgcatccatt agtagtcgtg gtcgaaccta ctatccagac     240

agtgtaaagg gccgattcac cgtctccaga gataatgcca ggaacatcct gtatctgcaa     300

gtgagcagtc tgaggtctga ggacacggcc atgtattatt gtacaagagg cgggactcat     360

tattcctacg gcaacggttt tgacttctgg ggccaaggca ccactctcac agtctcctca     420


<210> 102
<211> 363
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1C10

<400> 102
gaagtgaaac tggttgagtc tgggggagtc ttagtgaagc ctggagggtc cctgaaattt      60

tcctgtgcag cctctggatt cactttcagt agccatgcct tgtcttgggt tcgccagact     120

ccagagaaga gactggagtg ggtcgcatcc attagtagtc gtggtcgaac ctactatcca     180

gacagtgtaa agggccgatt caccgtctcc agagataatg ccaggaacat cctgtatctg     240

caagtgagca gtctgaggtc tgaggacacg gccatgtatt attgtacaag aggcgggact     300

cattattcct acggcaacgg ttttgacttc tggggccaag gcaccactct cacagtctcc     360

tca                                                                   363


<210> 103
<211> 140
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1C10,
      wherein positions 1-19 correspond to a leader sequence

<400> 103
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Val Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Lys Phe Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser His Ala Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Ser Ile Ser Ser Arg Gly Arg Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Asn Ile 
                85                  90                  95      
Leu Tyr Leu Gln Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         
Tyr Cys Thr Arg Gly Gly Thr His Tyr Ser Tyr Gly Asn Gly Phe Asp 
        115                 120                 125             
Phe Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 

<210> 104
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1C10, without the leader sequence

<400> 104
Glu Val Lys Leu Val Glu Ser Gly Gly Val Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Phe Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          
Ala Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Ser Arg Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  
Gln Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      
Arg Gly Gly Thr His Tyr Ser Tyr Gly Asn Gly Phe Asp Phe Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     

<210> 105
<211> 378
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1C10

<400> 105
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtcaa      60

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg     120

acctgcagtg tcagctcaag tgttagttac atgcactggt accagcagaa gtcaggcacc     180

tcccccaaaa gatggattta tgacacatcc aaactggctt ctggagtccc tgctcgcttc     240

agtggcagtg ggtctgggac ctcttactct ctcacaatca gcaccatgga ggctgaagat     300

gctgccactt attactgcca gcagtggagt aataacccac ccatcacgtt cggtgctggg     360

accaagctgg aactgaaa                                                   378


<210> 106
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1C10

<400> 106
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc      60

atgacctgca gtgtcagctc aagtgttagt tacatgcact ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcaccat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg agtaataacc cacccatcac gttcggtgct     300

gggaccaagc tggaactgaa a                                               321


<210> 107
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1C10,
      wherein positions 1-19 correspond to a leader sequence

<400> 107
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val 
        35                  40                  45              
Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    50                  55                  60                  
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met 
                85                  90                  95      
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn 
            100                 105                 110         
Pro Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125     

<210> 108
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1C10, without the leader sequence

<400> 108
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Pro Ile 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 109
<211> 15
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR1 sequence of 1C10, 1A10

<400> 109
agccatgcct tgtct                                                     15


<210> 110
<211> 48
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR2 sequence of 1C10, 1A10

<400> 110
tccattagta gtcgtggtcg aacctactat ccagacagtg taaagggc                  48


<210> 111
<211> 39
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH-CDR3 sequence of 1C10, 1A10

<400> 111
ggcgggactc attattccta cggcaacggt tttgacttc                            39


<210> 112
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1 sequence of 1C10, 1A10

<400> 112
Ser His Ala Leu Ser 
1               5   

<210> 113
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2 sequence of 1C10, 1A10

<400> 113
Ser Ile Ser Ser Arg Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 114
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3 sequence of 1C10, 1A10

<400> 114
Gly Gly Thr His Tyr Ser Tyr Gly Asn Gly Phe Asp Phe 
1               5                   10              

<210> 115
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL-CDR1 sequence of 1C10, 1A10

<400> 115
agtgtcagct caagtgttag ttacatgcac                                     30


<210> 116
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL-CDR3 sequence of 1C10, 1A10

<400> 116
cagcagtgga gtaataaccc acccatcacg                                     30


<210> 117
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1 sequence of 1C10, 1A10

<400> 117
Ser Val Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  

<210> 118
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3 sequence of 1C10, 1A10

<400> 118
Gln Gln Trp Ser Asn Asn Pro Pro Ile Thr 
1               5                   10  

<210> 119
<211> 420
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1A10

<400> 119
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgaa      60

gtgaaactgg ttgagtctgg gggagtctta gtgaagcctg gagggtccct gaaattttcc     120

tgtgcagcct ctggattcac tctcagtagc catgccttgt cttgggttcg ccagactcca     180

gagaagagac tggagtgggt cgcatccatt agtagtcgtg gtcgaaccta ctatccagac     240

agtgtaaagg gccgattcac cgtctccaga gataatgcca ggaacatcct gtatctgcaa     300

gtgagcagtc tgaggtctga ggacacggcc atgtattatt gtacaagagg cgggactcat     360

tattcctacg gcaacggttt tgacttctgg ggccaaggca ccactctcac agtctcctca     420


<210> 120
<211> 363
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1A10

<400> 120
gaagtgaaac tggttgagtc tgggggagtc ttagtgaagc ctggagggtc cctgaaattt      60

tcctgtgcag cctctggatt cactctcagt agccatgcct tgtcttgggt tcgccagact     120

ccagagaaga gactggagtg ggtcgcatcc attagtagtc gtggtcgaac ctactatcca     180

gacagtgtaa agggccgatt caccgtctcc agagataatg ccaggaacat cctgtatctg     240

caagtgagca gtctgaggtc tgaggacacg gccatgtatt attgtacaag aggcgggact     300

cattattcct acggcaacgg ttttgacttc tggggccaag gcaccactct cacagtctcc     360

tca                                                                   363


<210> 121
<211> 140
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VH sequence of 1A10,
      wherein positions 1-19 correspond to a leader sequence

<400> 121
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Val Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Lys Phe Ser Cys Ala Ala Ser Gly Phe Thr Leu 
        35                  40                  45              
Ser Ser His Ala Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Ser Ile Ser Ser Arg Gly Arg Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Asn Ile 
                85                  90                  95      
Leu Tyr Leu Gln Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         
Tyr Cys Thr Arg Gly Gly Thr His Tyr Ser Tyr Gly Asn Gly Phe Asp 
        115                 120                 125             
Phe Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 

<210> 122
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VH sequence of 1A10, without the leader sequence

<400> 122
Glu Val Lys Leu Val Glu Ser Gly Gly Val Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Phe Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser His 
            20                  25                  30          
Ala Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Ser Arg Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  
Gln Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      
Arg Gly Gly Thr His Tyr Ser Tyr Gly Asn Gly Phe Asp Phe Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     

<210> 123
<211> 378
<212> DNA
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1A10

<400> 123
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtcaa      60

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg     120

acctgcagtg tcagctcaag tgttagttac atgcactggt accagcagaa gtcaggcacc     180

tcccccaaaa gatggattta tgacacatcc aaactggctt ctggagtccc tgctcgcttc     240

agtggcagtg ggtctgggac ctcttactct ctcacaatca gcaccatgga ggctgaagat     300

gctgccactt attactgcca gcagtggagt aataacccac ccatcacgtt cggtgctggg     360

accaagctgg aactgaaa                                                   378


<210> 124
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1A10

<400> 124
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc      60

atgacctgca gtgtcagctc aagtgttagt tacatgcact ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcaccat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg agtaataacc cacccatcac gttcggtgct     300

gggaccaagc tggaactgaa a                                               321


<210> 125
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immature form of the recombinantly expressed VL sequence of 1A10,
      wherein positions 1-19 correspond to a leader sequence

<400> 125
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val 
        35                  40                  45              
Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    50                  55                  60                  
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met 
                85                  90                  95      
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn 
            100                 105                 110         
Pro Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125     

<210> 126
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mature form of VL sequence of 1A10, without the leader sequence

<400> 126
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Pro Ile 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 127
<211> 354
<212> PRT
<213> Artificial Sequence


<220> 
<223> Full sequence of US28 as encoded by HCMV strain BL (Accession
      number MW980585.1)

<400> 127
Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      
Asp Glu Asp Ala Ala Pro Cys Val Leu Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Leu Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Lys Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Ala Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro 
        

<210> 128
<400> 128
000

<210> 129
<400> 129
000

<210> 130
<400> 130
000

<210> 131
<400> 131
000

<210> 132
<400> 132
000

<210> 133
<400> 133
000

<210> 134
<400> 134
000

<210> 135
<400> 135
000

<210> 136
<400> 136
000

<210> 137
<400> 137
000

<210> 138
<400> 138
000

<210> 139
<400> 139
000

<210> 140
<400> 140
000

<210> 141
<400> 141
000

<210> 142
<400> 142
000

<210> 143
<400> 143
000

<210> 144
<400> 144
000

<210> 145
<400> 145
000

<210> 146
<400> 146
000

<210> 147
<211> 1396
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1G9

<400> 147
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgaa      60

gtgaagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc     120

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagactcca     180

gagaagaggc tggagtgggt cgcatccatt agtagtggtg gtagcaccta ctatccagac     240

agtgtgaagg gccgattcac catctccaga gataatgcca ggaacatcct gtacctgcaa     300

atgagcagtc tgaggtctga ggacacggcc atgtattact gtgcaagagg cgggtctact     360

atgattacga cggggctggg gtttgcttac tggggccaag ggactctggt cactgtctct     420

gcacaaaacg acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa     480

ctccatggtg accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac     540

ctggaactct ggatccctgt ccagcggtgt gcacaccttc ccagctgtcc tgcagtctga     600

cctctacact ctgagcagct cagtgactgt cccctccagc acctggccca gcgagaccgt     660

cacctgcaac gttgcccacc cggccagcag caccaaggtg gacaagaaaa ttgtgcccag     720

ggattgtggt tgtaagcctt gcatatgtac agtcccagaa gtatcatctg tcttcatctt     780

ccccccaaag cccaaggatg tgctcaccat tactctgact cctaaggtca cgtgtgttgt     840

ggtagacatc agcaaggatg atcccgaggt ccagttcagc tggtttgtag atgatgtgga     900

ggtgcacaca gctcagacgc aaccccggga ggagcagttc aacagcactt tccgctcagt     960

cagtgaactt cccatcatgc accaggactg gctcaatggc aaggagttca aatgcagggt    1020

caacagtgca gctttccctg cccccatcga gaaaaccatc tccaaaacca aaggcagacc    1080

gaaggctcca caggtgtaca ccattccacc tcccaaggag cagatggcca aggataaagt    1140

cagtctgacc tgcatgataa cagacttctt ccctgaagac attactgtgg agtggcagtg    1200

gaatgggcag ccagcggaga actacaagaa cactcagccc atcatggaca cagatggctc    1260

ttacttcatc tacagcaagc tcaatgtgca gaagagcaac tgggaggcag gaaatacttt    1320

cacctgctct gtgttacatg agggcctgca caaccaccat actgagaaga gcctctccca    1380

ctctcctggt aaatga                                                    1396


<210> 148
<211> 702
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1G9

<400> 148
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtcaa      60

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg     120

acctgcagtg ccagctcaag tgtaagttac atgcactggt accagcagaa gtcaggcacc     180

tcccccaaaa gatggattta tgacacatcc aaactggctt ctggagtccc tgctcgcttc     240

agtggcagtg ggtctgggac ctcttactct ctcacaatca gcagcatgga ggctgaagat     300

gctgccactt attactgcca gcagtggagt agtaacccac ccctcacgtt cggtgctggg     360

accaagctgg agctgaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc     420

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc     480

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac     540

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg     600

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca     660

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                        702


<210> 149
<211> 465
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1G9

<400> 149
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile 
                85                  90                  95      
Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Gly Gly Ser Thr Met Ile Thr Thr Gly Leu Gly Phe 
        115                 120                 125             
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr 
    130                 135                 140                 
Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
145                 150                 155                 160 
Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     
Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         
Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             
Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn 
    210                 215                 220                 
Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
225                 230                 235                 240 
Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
                245                 250                 255     
Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
            260                 265                 270         
Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
        275                 280                 285             
Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
    290                 295                 300                 
Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
305                 310                 315                 320 
Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     
Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
            340                 345                 350         
Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
        355                 360                 365             
Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
    370                 375                 380                 
Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
385                 390                 395                 400 
Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
                405                 410                 415     
Asp Thr Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys 
            420                 425                 430         
Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
        435                 440                 445             
Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
    450                 455                 460                 
Lys 
465 

<210> 150
<211> 233
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1G9

<400> 150
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              
Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    50                  55                  60                  
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
                85                  90                  95      
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
            100                 105                 110         
Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala 
        115                 120                 125             
Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 
Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     
Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             
Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 
Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             

<210> 151
<211> 1393
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1E8

<400> 151
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgaa      60

gtgaagctgg tggagtctgg gggagactta gtgaagcctg gagggtccct gaaactctcc     120

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagactcca     180

gagaagaggc tggagtgggt cgcatccatt agtagtggtg gtagaaccta ctatccagac     240

agtgtgaagg gccgattcac catctccaga gataatgcca ggaacatcct gtacctgcaa     300

atgagcagtc tgaggtctga agacacggcc atctattact gtgcacgagg cgggactcgt     360

cattcctacg gcaacgggtt tgactactgg ggccaaggca ccactctcac agtctcctca     420

caaaacgaca cccccatctg tctatccact ggcccctgga tctgctgccc aaactaactc     480

catggtgacc ctgggatgcc tggtcaaggg ctatttccct gagccagtga cagtgacctg     540

gaactctgga tccctgtcca gcggtgtgca caccttccca gctgtcctgc agtctgacct     600

ctacactctg agcagctcag tgactgtccc ctccagcacc tggcccagcg agaccgtcac     660

ctgcaacgtt gcccacccgg ccagcagcac caaggtggac aagaaaattg tgcccaggga     720

ttgtggttgt aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc     780

cccaaagccc aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt     840

agacatcagc aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt     900

gcacacagct cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag     960

tgaacttccc atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa    1020

cagtgcagct ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa    1080

ggctccacag gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag    1140

tctgacctgc atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa    1200

tgggcagcca gcggagaact acaagaacac tcagcccatc atggacacag atggctctta    1260

cttcatctac agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac    1320

ctgctctgtg ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc    1380

tcctggtaaa tga                                                       1393


<210> 152
<211> 702
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1E8

<400> 152
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtcaa      60

attgttctct cccagtctcc aacaatcatg tctgcatctc caggggagaa ggtcaccatg     120

acctgcagtg ccagctcaag tgtaagttac atgcactggt accagcagaa gtcaggcacc     180

tcccccaaaa gatggattta tgactcatcc aaactggctt ctggagtccc tgctcgcttc     240

agtggcagtg ggtctgggac ctcttactct ctcacaatca gcagcatgga ggctgaagat     300

gctgccactt attactgcca gcagtggact agtaacccac ccatcacgtt cggtgctggg     360

accaagctgg agctgaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc     420

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc     480

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac     540

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg     600

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca     660

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                        702


<210> 153
<211> 464
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1E8

<400> 153
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Ser Ile Ser Ser Gly Gly Arg Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile 
                85                  90                  95      
Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Gly Gly Thr Arg His Ser Tyr Gly Asn Gly Phe Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 
Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 
Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     
Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             
Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 
Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 
Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     
Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         
Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             
Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 
Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 
Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     
Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         
Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             
Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 
Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 
Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     
Thr Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         
Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             
Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 



<210> 154
<211> 233
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1E8

<400> 154
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Met Ser Ala 
            20                  25                  30          
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              
Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    50                  55                  60                  
Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
                85                  90                  95      
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn 
            100                 105                 110         
Pro Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala 
        115                 120                 125             
Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 
Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     
Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             
Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 
Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             

<210> 155
<211> 1393
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1C10

<400> 155
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgaa      60

gtgaaactgg ttgagtctgg gggagtctta gtgaagcctg gagggtccct gaaattttcc     120

tgtgcagcct ctggattcac tttcagtagc catgccttgt cttgggttcg ccagactcca     180

gagaagagac tggagtgggt cgcatccatt agtagtcgtg gtcgaaccta ctatccagac     240

agtgtaaagg gccgattcac cgtctccaga gataatgcca ggaacatcct gtatctgcaa     300

gtgagcagtc tgaggtctga ggacacggcc atgtattatt gtacaagagg cgggactcat     360

tattcctacg gcaacggttt tgacttctgg ggccaaggca ccactctcac agtctcctca     420

caaaacgaca cccccatctg tctatccact ggcccctgga tctgctgccc aaactaactc     480

catggtgacc ctgggatgcc tggtcaaggg ctatttccct gagccagtga cagtgacctg     540

gaactctgga tccctgtcca gcggtgtgca caccttccca gctgtcctgc agtctgacct     600

ctacactctg agcagctcag tgactgtccc ctccagcacc tggcccagcg agaccgtcac     660

ctgcaacgtt gcccacccgg ccagcagcac caaggtggac aagaaaattg tgcccaggga     720

ttgtggttgt aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc     780

cccaaagccc aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt     840

agacatcagc aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt     900

gcacacagct cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag     960

tgaacttccc atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa    1020

cagtgcagct ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa    1080

ggctccacag gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag    1140

tctgacctgc atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa    1200

tgggcagcca gcggagaact acaagaacac tcagcccatc atggacacag atggctctta    1260

cttcatctac agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac    1320

ctgctctgtg ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc    1380

tcctggtaaa tga                                                       1393


<210> 156
<211> 702
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1C10

<400> 156
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtcaa      60

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg     120

acctgcagtg tcagctcaag tgttagttac atgcactggt accagcagaa gtcaggcacc     180

tcccccaaaa gatggattta tgacacatcc aaactggctt ctggagtccc tgctcgcttc     240

agtggcagtg ggtctgggac ctcttactct ctcacaatca gcaccatgga ggctgaagat     300

gctgccactt attactgcca gcagtggagt aataacccac ccatcacgtt cggtgctggg     360

accaagctgg aactgaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc     420

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc     480

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac     540

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg     600

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca     660

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                        702


<210> 157
<211> 464
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1C10

<400> 157
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Val Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Lys Phe Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser His Ala Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Ser Ile Ser Ser Arg Gly Arg Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Asn Ile 
                85                  90                  95      
Leu Tyr Leu Gln Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         
Tyr Cys Thr Arg Gly Gly Thr His Tyr Ser Tyr Gly Asn Gly Phe Asp 
        115                 120                 125             
Phe Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 
Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 
Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     
Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             
Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 
Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 
Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     
Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         
Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             
Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 
Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 
Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     
Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         
Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             
Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 
Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 
Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     
Thr Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         
Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             
Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 



<210> 158
<211> 233
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1C10

<400> 158
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val 
        35                  40                  45              
Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    50                  55                  60                  
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met 
                85                  90                  95      
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn 
            100                 105                 110         
Pro Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala 
        115                 120                 125             
Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 
Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     
Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             
Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 
Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             

<210> 159
<211> 1393
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1A10

<400> 159
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgaa      60

gtgaaactgg ttgagtctgg gggagtctta gtgaagcctg gagggtccct gaaattttcc     120

tgtgcagcct ctggattcac tctcagtagc catgccttgt cttgggttcg ccagactcca     180

gagaagagac tggagtgggt cgcatccatt agtagtcgtg gtcgaaccta ctatccagac     240

agtgtaaagg gccgattcac cgtctccaga gataatgcca ggaacatcct gtatctgcaa     300

gtgagcagtc tgaggtctga ggacacggcc atgtattatt gtacaagagg cgggactcat     360

tattcctacg gcaacggttt tgacttctgg ggccaaggca ccactctcac agtctcctca     420

caaaacgaca cccccatctg tctatccact ggcccctgga tctgctgccc aaactaactc     480

catggtgacc ctgggatgcc tggtcaaggg ctatttccct gagccagtga cagtgacctg     540

gaactctgga tccctgtcca gcggtgtgca caccttccca gctgtcctgc agtctgacct     600

ctacactctg agcagctcag tgactgtccc ctccagcacc tggcccagcg agaccgtcac     660

ctgcaacgtt gcccacccgg ccagcagcac caaggtggac aagaaaattg tgcccaggga     720

ttgtggttgt aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc     780

cccaaagccc aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt     840

agacatcagc aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt     900

gcacacagct cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag     960

tgaacttccc atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa    1020

cagtgcagct ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa    1080

ggctccacag gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag    1140

tctgacctgc atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa    1200

tgggcagcca gcggagaact acaagaacac tcagcccatc atggacacag atggctctta    1260

cttcatctac agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac    1320

ctgctctgtg ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc    1380

tcctggtaaa tga                                                       1393


<210> 160
<211> 702
<212> DNA
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1A10

<400> 160
atgaagttgc ctgttaggct gttggtgctg atggtctgga ttcctgcttc cagcagtcaa      60

attgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg     120

acctgcagtg tcagctcaag tgttagttac atgcactggt accagcagaa gtcaggcacc     180

tcccccaaaa gatggattta tgacacatcc aaactggctt ctggagtccc tgctcgcttc     240

agtggcagtg ggtctgggac ctcttactct ctcacaatca gcaccatgga ggctgaagat     300

gctgccactt attactgcca gcagtggagt aataacccac ccatcacgtt cggtgctggg     360

accaagctgg aactgaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc     420

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc     480

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac     540

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg     600

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca     660

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                        702


<210> 161
<211> 464
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the heavy chain of 1A10

<400> 161
Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      
Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Val Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Lys Phe Ser Cys Ala Ala Ser Gly Phe Thr Leu 
        35                  40                  45              
Ser Ser His Ala Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Ser Ile Ser Ser Arg Gly Arg Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Asn Ile 
                85                  90                  95      
Leu Tyr Leu Gln Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         
Tyr Cys Thr Arg Gly Gly Thr His Tyr Ser Tyr Gly Asn Gly Phe Asp 
        115                 120                 125             
Phe Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 
Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 
Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     
Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             
Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 
Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 
Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     
Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         
Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             
Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 
Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 
Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     
Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         
Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             
Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 
Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 
Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     
Thr Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         
Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             
Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 



<210> 162
<211> 233
<212> PRT
<213> Artificial Sequence


<220> 
<223> Complete sequence of the light chain of 1A10

<400> 162
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Val Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val 
        35                  40                  45              
Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    50                  55                  60                  
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met 
                85                  90                  95      
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn 
            100                 105                 110         
Pro Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala 
        115                 120                 125             
Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 
Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     
Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             
Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 
Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             

<210> 163
<400> 163
000

<210> 164
<400> 164
000

<210> 165
<400> 165
000

<210> 166
<400> 166
000

<210> 167
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> X2 = Y or H; X4 = M or L

<220> 
<221> VARIANT
<222> 2
<223> Y or H

<220> 
<221> VARIANT
<222> 4
<223> M or L

<400> 167
Ser Xaa Ala Xaa Ser 
1               5   

<210> 168
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> X5 = G or R; X7 = S or R

<220> 
<221> VARIANT
<222> 5
<223> G or R

<220> 
<221> VARIANT
<222> 7
<223> S or R

<400> 168
Ser Ile Ser Ser Xaa Gly Xaa Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 169
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> X3 = S or T; X4 = T, R or H; X5 = M, H or Y; X6 = I or S; X7 = T
      or Y; X8 = T or G; X9 = G or N; X10 = L or blank; X13 = A or D;
      X14 = Y or F

<220> 
<221> VARIANT
<222> 3
<223> S or T

<220> 
<221> VARIANT
<222> 4
<223> T, R or H

<220> 
<221> VARIANT
<222> 5
<223> M, H or Y

<220> 
<221> VARIANT
<222> 6
<223> I or S

<220> 
<221> VARIANT
<222> 7
<223> T or Y

<220> 
<221> VARIANT
<222> 8
<223> T or G

<220> 
<221> VARIANT
<222> 9
<223> G or N

<220> 
<221> VARIANT
<222> 10
<223> L or blank (also denoted as *)

<220> 
<221> VARIANT
<222> 13
<223> A or D

<220> 
<221> VARIANT
<222> 14
<223> Y or F

<400> 169
Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Phe Xaa Xaa 
1               5                   10                  

<210> 170
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> X2 = A or V

<220> 
<221> VARIANT
<222> 2
<223> A or V

<400> 170
Ser Xaa Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  

<210> 171
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> X2 = T or S

<220> 
<221> VARIANT
<222> 2
<223> T or S

<400> 171
Asp Xaa Ser Lys Leu Ala Ser 
1               5           

<210> 172
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> X4 = S, T or blank; X7 = blank or N; X10 = I or L

<220> 
<221> VARIANT
<222> 4
<223> S, T or blank (also denoted as *)

<220> 
<221> VARIANT
<222> 7
<223> N or blank (also denoted as *)

<220> 
<221> VARIANT
<222> 10
<223> I or L

<400> 172
Gln Gln Trp Xaa Ser Asn Xaa Pro Pro Xaa Thr 
1               5                   10      

<210> 173
<211> 353
<212> PRT
<213> Artificial Sequence


<220> 
<223> Artifically mutated strain of US28

<400> 173
Met Thr Gln Thr Thr Thr Thr Glu Leu Thr Thr Glu Phe Asp Tyr Asp 
1               5                   10                  15      
Leu Gly Ala Ala Leu Cys Thr Leu Thr Asp Val Leu Asn Gln Ser Lys 
            20                  25                  30          
Pro Ile Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser Ile 
        35                  40                  45              
Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile Gln 
    50                  55                  60                  
Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu Leu 
65                  70                  75                  80  
Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His Asn 
                85                  90                  95      
Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr Val 
            100                 105                 110         
Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp Arg 
        115                 120                 125             
Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala Cys 
    130                 135                 140                 
Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile Pro 
145                 150                 155                 160 
His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp Tyr 
                165                 170                 175     
Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu Met 
            180                 185                 190         
Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr Tyr 
        195                 200                 205             
Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly Arg 
    210                 215                 220                 
Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe Trp 
225                 230                 235                 240 
Leu Pro Tyr His Leu Thr Leu Phe Leu Asp Thr Leu Lys Leu Leu Lys 
                245                 250                 255     
Trp Ile Ser Ser Ser Cys Glu Ser Glu Lys Ser Leu Lys Arg Ala Leu 
            260                 265                 270         
Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro Leu 
        275                 280                 285             
Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys Leu 
    290                 295                 300                 
Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp Tyr 
305                 310                 315                 320 
His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu Thr 
                325                 330                 335     
Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile Ile 
            340                 345                 350         
Pro 
    

<210> 174
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> Wherein X = G or R

<220> 
<221> VARIANT
<222> 5
<223> G or R

<400> 174
Ser Ile Ser Ser Xaa Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 175
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> X3 = S or T; X4 = T, R or H; X5 = M, H or Y; X6 = I or S; X7 = T
      or Y; X8 = T or G; X9 = G or N; X12 = A or D; X13 = Y or F

<220> 
<221> VARIANT
<222> 3
<223> S or T

<220> 
<221> VARIANT
<222> 4
<223> T, R or H

<220> 
<221> VARIANT
<222> 5
<223> M, H or Y

<220> 
<221> VARIANT
<222> 6
<223> I or S

<220> 
<221> VARIANT
<222> 7
<223> T or Y

<220> 
<221> VARIANT
<222> 8
<223> T or G

<220> 
<221> VARIANT
<222> 9
<223> G or N

<220> 
<221> VARIANT
<222> 12
<223> A or D

<220> 
<221> VARIANT
<222> 13
<223> Y or F

<400> 175
Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Phe Xaa Xaa 
1               5                   10              

<210> 176
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> X4 = T or blank; X7 = blank or N; X10 = I or L

<220> 
<221> VARIANT
<222> 4
<223> T or blank

<220> 
<221> VARIANT
<222> 7
<223> N or blank

<220> 
<221> VARIANT
<222> 10
<223> I or L

<400> 176
Gln Gln Trp Xaa Ser Asn Xaa Pro Pro Xaa Thr 
1               5                   10      

<210> 177
<211> 367
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 fusion protein, comprising US28 sequence from HCMV TB40/E
      strain

<400> 177
Met Thr Pro Thr Thr Thr Thr Thr Glu Leu Thr Thr Glu Phe Glu Tyr 
1               5                   10                  15      
Asp Leu Gly Ala Thr Pro Cys Thr Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          
Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              
Val Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  
Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  
Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      
Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         
Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             
Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 
Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 
Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     
Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         
Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             
Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 
Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 
Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     
Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         
Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             
Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 
Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 
Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     
Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         
Ile Pro Ala Ala Ala Leu Glu Gly Ser His His His His His His 
        355                 360                 365         

<210> 178
<211> 366
<212> PRT
<213> Artificial Sequence


<220> 
<223> US28 fusion protein, comprising US28 sequence from HCMV mutated
      strain

<400> 178
Met Thr Gln Thr Thr Thr Thr Glu Leu Thr Thr Glu Phe Asp Tyr Asp 
1               5                   10                  15      
Leu Gly Ala Ala Leu Cys Thr Leu Thr Asp Val Leu Asn Gln Ser Lys 
            20                  25                  30          
Pro Ile Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser Ile 
        35                  40                  45              
Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile Gln 
    50                  55                  60                  
Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu Leu 
65                  70                  75                  80  
Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His Asn 
                85                  90                  95      
Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr Val 
            100                 105                 110         
Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp Arg 
        115                 120                 125             
Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala Cys 
    130                 135                 140                 
Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile Pro 
145                 150                 155                 160 
His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp Tyr 
                165                 170                 175     
Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu Met 
            180                 185                 190         
Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr Tyr 
        195                 200                 205             
Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly Arg 
    210                 215                 220                 
Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe Trp 
225                 230                 235                 240 
Leu Pro Tyr His Leu Thr Leu Phe Leu Asp Thr Leu Lys Leu Leu Lys 
                245                 250                 255     
Trp Ile Ser Ser Ser Cys Glu Ser Glu Lys Ser Leu Lys Arg Ala Leu 
            260                 265                 270         
Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro Leu 
        275                 280                 285             
Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys Leu 
    290                 295                 300                 
Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp Tyr 
305                 310                 315                 320 
His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu Thr 
                325                 330                 335     
Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile Ile 
            340                 345                 350         
Pro Ala Ala Ala Leu Glu Gly Ser His His His His His His 
        355                 360                 365     

