                         SEQUENCE LISTING

<110>  Inserm
 
<120>  CHLAMYDIA TRACHOMATIS ANTIGENIC POLYPEPTIDES AND USES THEREOF FOR
        VACCINE PURPOSES

<130>  BIO205 LEVY / MC

<160>  48    

<170>  PatentIn version 3.3

<210>  1
<211>  149
<212>  PRT
<213>  Artificial

<220>
<223>  CD40L binding domain

<400>  1

Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
1               5                   10                  15      


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
        35                  40                  45              


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
    50                  55                  60                  


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
65                  70                  75                  80  


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
                85                  90                  95      


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
            100                 105                 110         


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
        115                 120                 125             


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
    130                 135                 140                 


Gly Leu Leu Lys Leu 
145                 


<210>  2
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  VS4 bis antigen

<400>  2

Ala Ser Ile Asp Tyr His Glu Trp Gln Ala Ser Leu Ala Leu Ser Tyr 
1               5                   10                  15      


Arg Leu Asn Met Phe Thr Pro Tyr Ile Gly Val Lys Trp Ser 
            20                  25                  30  


<210>  3
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  YchM antigen

<400>  3

Glu Lys Pro Pro Lys Ile Phe Ile Leu Cys Met Thr Arg Val Pro Thr 
1               5                   10                  15      


Ile Asp Ala Ser Ala Met His Ala Leu Glu Glu Phe Phe Leu 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  PgP3 antigen

<400>  4

Gly Lys Phe Thr Val Thr Pro Lys Ser Ser Gly Ser Met Phe Leu Val 
1               5                   10                  15      


Ser Ala Asp Ile Ile Ala Ser Arg Met Glu Gly Gly Val Val 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  PmPG antigen

<400>  5

Pro Ala Ala Asn Gln Leu Ile Thr Leu Ser Asn Leu His Leu Ser Leu 
1               5                   10                  15      


Ser Ser Leu Leu Ala Asn Asn Ala Val Thr Asn Pro Pro Thr 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  NqrC antigen

<400>  6

Cys Asn Gly Val Thr Glu Ser Phe Ser His Ser Leu Ala Pro Tyr Arg 
1               5                   10                  15      


Ala Leu Leu Thr Phe Phe Ala Asn Ser Lys Pro Ser Gly Glu 
            20                  25                  30  


<210>  7
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  7

Gln Thr Pro Thr Asn Thr Ile Ser Val Thr Pro Thr Asn Asn Ser Thr 
1               5                   10                  15      


Pro Thr Asn Asn Ser Asn Pro Lys Pro Asn Pro 
            20                  25          


<210>  8
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  8

Ser Ser Val Ser Pro Thr Thr Ser Val His Pro Thr Pro Thr Ser Val 
1               5                   10                  15      


Pro Pro Thr Pro Thr Lys Ser Ser Pro 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  9

Pro Thr Ser Thr Pro Ala Asp Ser Ser Thr Ile Thr Pro Thr Ala Thr 
1               5                   10                  15      


Pro Thr Ala Thr Pro Thr Ile Lys Gly 
            20                  25  


<210>  10
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  10

Thr Val Thr Pro Thr Ala Thr Ala Thr Pro Ser Ala Ile Val Thr Thr 
1               5                   10                  15      


Ile Thr Pro Thr Ala Thr Thr Lys Pro 
            20                  25  


<210>  11
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  11

Thr Asn Gly Ser Ile Thr Val Ala Ala Thr Ala Pro Thr Val Thr Pro 
1               5                   10                  15      


Thr Val Asn Ala Thr Pro Ser Ala Ala 
            20                  25  


<210>  12
<211>  250
<212>  PRT
<213>  Artificial

<220>
<223>  fusion protein

<400>  12

Ala Ser Ile Asp Tyr His Glu Trp Gln Ala Ser Leu Ala Leu Ser Tyr 
1               5                   10                  15      


Arg Leu Asn Met Phe Thr Pro Tyr Ile Gly Val Lys Trp Ser Ser Ser 
            20                  25                  30          


Val Ser Pro Thr Thr Ser Val His Pro Thr Pro Thr Ser Val Pro Pro 
        35                  40                  45              


Thr Pro Thr Lys Ser Ser Pro Pro Ala Ala Asn Gln Leu Ile Thr Leu 
    50                  55                  60                  


Ser Asn Leu His Leu Ser Leu Ser Ser Leu Leu Ala Asn Asn Ala Val 
65                  70                  75                  80  


Thr Asn Pro Pro Thr Pro Thr Ser Thr Pro Ala Asp Ser Ser Thr Ile 
                85                  90                  95      


Thr Pro Thr Ala Thr Pro Thr Ala Thr Pro Thr Ile Lys Gly Gly Lys 
            100                 105                 110         


Phe Thr Val Thr Pro Lys Ser Ser Gly Ser Met Phe Leu Val Ser Ala 
        115                 120                 125             


Asp Ile Ile Ala Ser Arg Met Glu Gly Gly Val Val Thr Val Thr Pro 
    130                 135                 140                 


Thr Ala Thr Ala Thr Pro Ser Ala Ile Val Thr Thr Ile Thr Pro Thr 
145                 150                 155                 160 


Ala Thr Thr Lys Pro Glu Lys Pro Pro Lys Ile Phe Ile Leu Cys Met 
                165                 170                 175     


Thr Arg Val Pro Thr Ile Asp Ala Ser Ala Met His Ala Leu Glu Glu 
            180                 185                 190         


Phe Phe Leu Thr Asn Gly Ser Ile Thr Val Ala Ala Thr Ala Pro Thr 
        195                 200                 205             


Val Thr Pro Thr Val Asn Ala Thr Pro Ser Ala Ala Cys Asn Gly Val 
    210                 215                 220                 


Thr Glu Ser Phe Ser His Ser Leu Ala Pro Tyr Arg Ala Leu Leu Thr 
225                 230                 235                 240 


Phe Phe Ala Asn Ser Lys Pro Ser Gly Glu 
                245                 250 


<210>  13
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR1

<400>  13

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Tyr 
1               5                   10  


<210>  14
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR2

<400>  14

Tyr Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR3

<400>  15

Arg Gly Leu Pro Phe His Ala Met Asp Tyr 
1               5                   10  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR1

<400>  16

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR2

<400>  17

Tyr Thr Ser Ile Leu His Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR3

<400>  18

Gln Gln Phe Asn Lys Leu Pro Pro Thr 
1               5                   


<210>  19
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR1

<400>  19

Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  20
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR2

<400>  20

Arg Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  21
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR3

<400>  21

Glu Asp Tyr Val Tyr 
1               5   


<210>  22
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR1

<400>  22

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR2

<400>  23

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR3

<400>  24

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR1

<400>  25

Gly Tyr Thr Phe Thr Asp Tyr Val Leu His 
1               5                   10  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR2

<400>  26

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  H-CDR3

<400>  27

Gly Tyr Pro Ala Tyr Ser Gly Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  28
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR1

<400>  28

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR2

<400>  29

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  L-CDR3

<400>  30

His His Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  31
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  31

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Val Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser 
        115     


<210>  32
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  32

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
            100                 105             


<210>  33
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  33

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Val Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser 
        115     


<210>  34
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  34

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Pro Ala Tyr Ser Gly Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser 
        115                 120             


<210>  35
<211>  103
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  35

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys His His Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  36
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  36

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe Tyr Tyr Gly Tyr Ser Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser 
        115                 120     


<210>  37
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  37

Gln Ile Val Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys 
            100         


<210>  38
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


<210>  39
<211>  103
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  40
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Pro Phe His Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120     


<210>  41
<211>  103
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Lys Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  42
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  42

Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser 
        115                 


<210>  43
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  43

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Arg Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
            100                 105             


<210>  44
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Leu 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Gly Arg Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser 
        115                 


<210>  45
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  VL domain

<400>  45

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Val Ser Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys 
            100                 105 


<210>  46
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  46

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asp His 
            20                  25                  30          


Asp Met His Trp Val Gln Gln Thr Pro Val Tyr Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Pro Phe Tyr Tyr Ser Asn Tyr Ser Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Ser 
        115                 120                 


<210>  47
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  47

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Arg Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys 
            100         


<210>  48
<211>  486
<212>  PRT
<213>  Artificial

<220>
<223>  cohesin fusion protein

<400>  48

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
            20                  25                  30          


Gln Lys Ile Glu Trp His Glu Asp Asp Leu Asp Ala Val Arg Ile Lys 
        35                  40                  45              


Val Asp Thr Val Asn Ala Lys Pro Gly Asp Thr Val Arg Ile Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ile Pro Ser Lys Gly Ile Ala Asn Cys Asp Phe Val 
65                  70                  75                  80  


Tyr Ser Tyr Asp Pro Asn Val Leu Glu Ile Ile Glu Ile Glu Pro Gly 
                85                  90                  95      


Asp Ile Ile Val Asp Pro Asn Pro Asp Lys Ser Phe Asp Thr Ala Val 
            100                 105                 110         


Tyr Pro Asp Arg Lys Ile Ile Val Phe Leu Phe Ala Glu Asp Ser Gly 
        115                 120                 125             


Thr Gly Ala Tyr Ala Ile Thr Lys Asp Gly Val Phe Ala Thr Ile Val 
    130                 135                 140                 


Ala Lys Val Lys Glu Gly Ala Pro Asn Gly Leu Ser Val Ile Lys Phe 
145                 150                 155                 160 


Val Glu Val Gly Gly Phe Ala Asn Asn Asp Leu Val Glu Gln Lys Thr 
                165                 170                 175     


Gln Phe Phe Asp Gly Gly Val Asn Val Gly Asp Thr Thr Glu Pro Ala 
            180                 185                 190         


Thr Pro Thr Thr Pro Val Thr Thr Pro Thr Thr Thr Asp Asp Leu Asp 
        195                 200                 205             


Ala Gln Thr Pro Thr Asn Thr Ile Ser Val Thr Pro Thr Asn Asn Ser 
    210                 215                 220                 


Thr Pro Thr Asn Asn Ser Asn Pro Lys Pro Asn Pro Ala Ser Ile Asp 
225                 230                 235                 240 


Tyr His Glu Trp Gln Ala Ser Leu Ala Leu Ser Tyr Arg Leu Asn Met 
                245                 250                 255     


Phe Thr Pro Tyr Ile Gly Val Lys Trp Ser Ser Ser Val Ser Pro Thr 
            260                 265                 270         


Thr Ser Val His Pro Thr Pro Thr Ser Val Pro Pro Thr Pro Thr Lys 
        275                 280                 285             


Ser Ser Pro Pro Ala Ala Asn Gln Leu Ile Thr Leu Ser Asn Leu His 
    290                 295                 300                 


Leu Ser Leu Ser Ser Leu Leu Ala Asn Asn Ala Val Thr Asn Pro Pro 
305                 310                 315                 320 


Thr Pro Thr Ser Thr Pro Ala Asp Ser Ser Thr Ile Thr Pro Thr Ala 
                325                 330                 335     


Thr Pro Thr Ala Thr Pro Thr Ile Lys Gly Gly Lys Phe Thr Val Thr 
            340                 345                 350         


Pro Lys Ser Ser Gly Ser Met Phe Leu Val Ser Ala Asp Ile Ile Ala 
        355                 360                 365             


Ser Arg Met Glu Gly Gly Val Val Thr Val Thr Pro Thr Ala Thr Ala 
    370                 375                 380                 


Thr Pro Ser Ala Ile Val Thr Thr Ile Thr Pro Thr Ala Thr Thr Lys 
385                 390                 395                 400 


Pro Glu Lys Pro Pro Lys Ile Phe Ile Leu Cys Met Thr Arg Val Pro 
                405                 410                 415     


Thr Ile Asp Ala Ser Ala Met His Ala Leu Glu Glu Phe Phe Leu Thr 
            420                 425                 430         


Asn Gly Ser Ile Thr Val Ala Ala Thr Ala Pro Thr Val Thr Pro Thr 
        435                 440                 445             


Val Asn Ala Thr Pro Ser Ala Ala Cys Asn Gly Val Thr Glu Ser Phe 
    450                 455                 460                 


Ser His Ser Leu Ala Pro Tyr Arg Ala Leu Leu Thr Phe Phe Ala Asn 
465                 470                 475                 480 


Ser Lys Pro Ser Gly Glu 
                485     


