                         SEQUENCE LISTING

<110>  Universitat Autònoma de Barcelona
 
<120>  Down-regulation of endogenous genes

<130>  P6100757PCT

<150>  EP 21382080.6
<151>  2021-01-30

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  1896
<212>  DNA
<213>  Homo sapiens

<400>  1
atggtttcta aactgagcca gctgcagacg gagctcctgg cggccctgct cgagtcaggg       60

ctgagcaaag aggcactgat ccaggcactg ggtgagccgg ggccctacct cctggctgga      120

gaaggccccc tggacaaggg ggagtcctgc ggcggcggtc gaggggagct ggctgagctg      180

cccaatgggc tgggggagac tcggggctcc gaggacgaga cggacgacga tggggaagac      240

ttcacgccac ccatcctcaa agagctggag aacctcagcc ctgaggaggc ggcccaccag      300

aaagccgtgg tggagaccct tctgcaggag gacccgtggc gtgtggcgaa gatggtcaag      360

tcctacctgc agcagcacaa catcccacag cgggaggtgg tcgataccac tggcctcaac      420

cagtcccacc tgtcccaaca cctcaacaag ggcactccca tgaagacgca gaagcgggcc      480

gccctgtaca cctggtacgt ccgcaagcag cgagaggtgg cgcagcagtt cacccatgca      540

gggcagggag ggctgattga agagcccaca ggtgatgagc taccaaccaa gaaggggcgg      600

aggaaccgtt tcaagtgggg cccagcatcc cagcagatcc tgttccaggc ctatgagagg      660

cagaagaacc ctagcaagga ggagcgagag acgctagtgg aggagtgcaa tagggcggaa      720

tgcatccaga gaggggtgtc cccatcacag gcacaggggc tgggctccaa cctcgtcacg      780

gaggtgcgtg tctacaactg gtttgccaac cggcgcaaag aagaagcctt ccggcacaag      840

ctggccatgg acacgtacag cgggcccccc ccagggccag gcccgggacc tgcgctgccc      900

gctcacagct cccctggcct gcctccacct gccctctccc ccagtaaggt ccacggtgtg      960

cgctatggac agcctgcgac cagtgagact gcagaagtac cctcaagcag cggcggtccc     1020

ttagtgacag tgtctacacc cctccaccaa gtgtccccca cgggcctgga gcccagccac     1080

agcctgctga gtacagaagc caagctggtc tcagcagctg ggggccccct cccccctgtc     1140

agcaccctga cagcactgca cagcttggag cagacatccc caggcctcaa ccagcagccc     1200

cagaacctca tcatggcctc acttcctggg gtcatgacca tcgggcctgg tgagcctgcc     1260

tccctgggtc ctacgttcac caacacaggt gcctccaccc tggtcatcgg cctggcctcc     1320

acgcaggcac agagtgtgcc ggtcatcaac agcatgggca gcagcctgac caccctgcag     1380

cccgtccagt tctcccagcc gctgcacccc tcctaccagc agccgctcat gccacctgtg     1440

cagagccatg tgacccagag ccccttcatg gccaccatgg ctcagctgca gagcccccac     1500

gccctctaca gccacaagcc cgaggtggcc cagtacaccc acacgggcct gctcccgcag     1560

actatgctca tcaccgacac caccaacctg agcgccctgg ccagcctcac gcccaccaag     1620

caggtcttca cctcagacac tgaggcctcc agtgagtccg ggcttcacac gccggcatct     1680

caggccacca ccctccacgt ccccagccag gaccctgcca gcatccagca cctgcagccg     1740

gcccaccggc tcagcgccag ccccacagtg tcctccagca gcctggtgct gtaccagagc     1800

tcagactcca gcaatggcca gagccacctg ctgccatcca accacagcgt catcgagacc     1860

ttcatctcca cccagatggc ctcttcctcc cagtaa                               1896


<210>  2
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcgactct ccaaaaccct cgtcgacatg gacatggccg actacagtgc tgcactggac       60

ccagcctaca ccaccctgga atttgagaat gtgcaggtgt tgacgatggg caatgacacg      120

tccccatcag aaggcaccaa cctcaacgcg cccaacagcc tgggtgtcag cgccctgtgt      180

gccatctgcg gggaccgggc cacgggcaaa cactacggtg cctcgagctg tgacggctgc      240

aagggcttct tccggaggag cgtgcggaag aaccacatgt actcctgcag atttagccgg      300

cagtgcgtgg tggacaaaga caagaggaac cagtgccgct actgcaggct caagaaatgc      360

ttccgggctg gcatgaagaa ggaagccgtc cagaatgagc gggaccggat cagcactcga      420

aggtcaagct atgaggacag cagcctgccc tccatcaatg cgctcctgca ggcggaggtc      480

ctgtcccgac agatcacctc ccccgtctcc gggatcaacg gcgacattcg ggcgaagaag      540

attgccagca tcgcagatgt gtgtgagtcc atgaaggagc agctgctggt tctcgttgag      600

tgggccaagt acatcccagc tttctgcgag ctccccctgg acgaccaggt ggccctgctc      660

agagcccatg ctggcgagca cctgctgctc ggagccacca agagatccat ggtgttcaag      720

gacgtgctgc tcctaggcaa tgactacatt gtccctcggc actgcccgga gctggcggag      780

atgagccggg tgtccatacg catccttgac gagctggtgc tgcccttcca ggagctgcag      840

atcgatgaca atgagtatgc ctacctcaaa gccatcatct tctttgaccc agatgccaag      900

gggctgagcg atccagggaa gatcaagcgg ctgcgttccc aggtgcaggt gagcttggag      960

gactacatca acgaccgcca gtatgactcg cgtggccgct ttggagagct gctgctgctg     1020

ctgcccacct tgcagagcat cacctggcag atgatcgagc agatccagtt catcaagctc     1080

ttcggcatgg ccaagattga caacctgttg caggagatgc tgctgggagg gtcccccagc     1140

gatgcacccc atgcccacca ccccctgcac cctcacctga tgcaggaaca tatgggaacc     1200

aacgtcatcg ttgccaacac aatgcccact cacctcagca acggacagat gtgtgagtgg     1260

ccccgaccca ggggacaggc agccacccct gagaccccac agccctcacc gccaggtggc     1320

tcagggtctg agccctataa gctcctgccg ggagccgtcg ccacaatcgt caagcccctc     1380

tctgccatcc cccagccgac catcaccaag caggaagtta tctag                     1425


<210>  3
<211>  1887
<212>  DNA
<213>  Mus musculus

<400>  3
atggtttcta agctgagcca gctgcagacg gagctcctgg ctgccctgct cgagtctggc       60

ctgagcaaag aggccctgat ccaggccttg ggggagccag ggccctacct gatggttgga      120

gagggtcccc tggacaaggg ggagtcctgc ggtgggagtc gaggggacct gaccgagttg      180

cctaatggcc ttggagaaac gcgtggctct gaagatgaca cggatgacga tggggaagac      240

ttcgcgccac ccattctgaa agagctggag aacctcagcc cagaggaggc agcccaccag      300

aaagccgtgg tggagtcact tcttcaggag gacccatggc gcgtggcgaa gatggtcaag      360

tcgtacttgc agcagcacaa catcccccag cgggaggtgg tggacaccac gggtctcaac      420

cagtcccacc tgtcacagca cctcaacaag ggcacaccca tgaagacaca gaagcgggcc      480

gctctgtaca cctggtacgt ccgcaagcag cgagaggtgg ctcagcaatt cacccacgca      540

gggcagggcg gactgattga agagcccaca ggcgatgagc tgccaactaa gaaggggcgt      600

aggaaccggt tcaagtgggg ccccgcatcc cagcagatcc tgttccaggc ctacgagagg      660

caaaaaaacc ccagcaagga agagcgagag accttggtgg aggagtgtaa tagggcggag      720

tgcatccaga ggggggtgtc accatcgcag gcccaggggc taggctccaa ccttgtcacg      780

gaggtgcgtg tctacaactg gtttgccaac cggcgcaagg aggaagcctt ccggcacaag      840

ttggccatgg acacctataa cggacctcca ccggggccag gcccgggccc tgcgctgcct      900

gctcacagtt cccccggcct gcccacaacc accctctctc ccagtaaggt ccacggtgta      960

cggtacggac agtctgcaac cagtgaggca gccgaggtgc cctccagcag cggaggtccc     1020

ttagtcacag tgtctgcggc cttacaccaa gtatccccca caggcctgga gcccagcagc     1080

ctgctgagca cagaggccaa gctggtctca gccacggggg gtcccctgcc tcccgtcagc     1140

accctgacag cactgcacag cttggagcag acatctccgg gtctcaacca gcagccgcag     1200

aaccttatca tggcctcgct acctggggtc atgaccatcg ggcccgggga gcctgcctcc     1260

ctgggaccca cgttcacgaa cacgggcgcc tccaccctgg ttatcggtct ggcctccact     1320

caggcacaga gcgtgcctgt catcaacagc atggggagta gcctgaccac gctgcagccg     1380

gtccagtttt cccaaccact gcatccctcc tatcagcagc ctctcatgcc ccccgtacag     1440

agccacgtgg cccagagccc cttcatggca accatggccc agctgcagag cccccacgcc     1500

ttatacagcc acaagcctga ggtggcccag tacacgcaca ccagcctgct cccgcagacc     1560

atgttgatca cagacaccaa cctcagcacc cttgccagcc tcacacccac caagcaggtc     1620

ttcacctcag acacagaggc ctccagtgag cccgggcttc acgagccacc ctctccagcc     1680

accaccatcc acatccccag ccaggacccg tcgaacatcc agcacctgca gcctgctcac     1740

cggctcagca ccagtcccac agtgtcctcc agcagcctgg tgttgtatca gagttccgac     1800

tccaacgggc acagccacct gctgccatcc aaccatagtg tcatcgagac ttttatctcc     1860

acccagatgg cctcctcttc ccagtaa                                         1887


<210>  4
<211>  1425
<212>  DNA
<213>  Mus musculus

<400>  4
atgcgactct ctaaaaccct tgccggcatg gatatggccg actacagcgc tgccctggac       60

ccagcctaca ccaccctgga gtttgaaaat gtgcaggtgt tgaccatggg caatgacacg      120

tccccatctg aaggtgccaa cctcaattca tccaacagcc tgggcgtcag tgccctgtgc      180

gccatctgtg gcgaccgggc caccggcaaa cactacggag cctcgagctg tgacggctgc      240

aaggggttct tcaggaggag cgtgaggaag aaccacatgt actcctgcag gtttagccga      300

caatgtgtgg tagacaaaga taagaggaac cagtgtcgtt actgcaggct taagaagtgc      360

ttccgggctg gcatgaagaa ggaagctgtc caaaatgagc gggaccggat cagcacgcgg      420

aggtcaagct acgaggacag cagcctgccc tccatcaacg cgctcctgca ggcagaggtt      480

ctgtcccagc agatcacctc tcccatctct gggatcaatg gcgacattcg ggcaaagaag      540

attgccaaca tcacagacgt gtgtgagtct atgaaggagc agctgctggt cctggtcgag      600

tgggccaagt acatcccggc cttctgcgaa ctccttctgg atgaccaggt ggcgctgctc      660

agggcccacg ccggtgagca tctgctgctt ggagccacca agaggtccat ggtgtttaag      720

gacgtgctgc tcctaggcaa tgactacatc gtccctcggc actgtccaga gctagcggag      780

atgagccgtg tgtccatccg catcctcgat gagctggtcc tgcccttcca agagctgcag      840

attgatgaca atgaatatgc ctgcctcaaa gccatcatct tctttgatcc agatgccaag      900

gggctgagtg acccgggcaa gatcaagcgg ctgcggtcac aggtgcaagt gagcctggag      960

gattacatca acgaccggca gtacgactct cggggccgct ttggagagct gctgctgctg     1020

ttgcccacgc tgcagagcat cacctggcag atgatcgaac agatccagtt catcaagctc     1080

ttcggcatgg ccaagattga caacctgctg caggagatgc ttctcggagg gtctgccagt     1140

gatgcacccc acacccacca ccccctgcac cctcacctga tgcaagaaca catgggcacc     1200

aatgtcattg ttgctaacac gatgccctct cacctcagca atggacagat gtgtgagtgg     1260

ccccgaccca gggggcaggc agccactccc gagactccac agccatcacc accaagtggc     1320

tcgggatctg aatcctacaa gctcctgcca ggagccatca ccaccatcgt caagcctccc     1380

tctgccattc cccagccaac gatcaccaag caagaagcca tctag                     1425


<210>  5
<211>  1896
<212>  DNA
<213>  Canis lupus familiaris

<400>  5
atggtttcta aactgagcca gctgcagacg gagctcctgg cggccctgct ccactcgggc       60

ctgagcaaag aggcactgat ccaggcgttg ggtgagccgg ggccctacct gctggctgga      120

gatggccccc tggacaaggg ggagtcctgc ggcggcggtc ggggggagct ggccgagctg      180

cccaacgggc tgggggaggc gaggggctcc gaggacgaga cggacgacga tggggaagac      240

ttcacaccgc ccatcctcaa ggagctggag aacctcagcc ccgaggaggc ggcccaccag      300

aaagccgtgg tggagacctt gctgcaggag gacccgtggc gcgtggccaa gatggtcaaa      360

tcctacctgc agcagcataa catcccacag cgggaggtag tcgacaccac tggcctcaac      420

cagtcacact tgtcccagca tctcaacaag ggcaccccca tgaagacaca gaagcgagct      480

gccctgtaca cctggtacgt ccgcaagcag cgagaggtgg cccagcagtt cacccacgca      540

gggcaaggtg ggctgattga agagcccaca ggtgatgagc tgccaaccaa gaaggggcgg      600

aggaatcgtt tcaagtgggg cccagcctcc cagcagatcc tgttccaggc ctatgagagg      660

cagaagaacc ccagcaagga ggagcgagag gcattggtgg aggagtgcaa tagggcggaa      720

tgcatccaga ggggggtgtc accatcgcag gcacaggggc tgggctccaa ccttgtcaca      780

gaggtgcgtg tctacaactg gtttgccaat cgccgcaagg aagaagcctt tcgtcataag      840

ctggccatgg acacatacag cgggccacca cctgggccag gcccgggccc cacactgcct      900

gcccacagct ctccgggctt gcccccacct gccctctccc ctagtaaggt ccacggtgtg      960

cgctatggac agcaagcaac tagcgagggg gcggaagtgc cttcgagcag cggtggtccc     1020

ttggtgacgg tgtctgcgcc cctgcaccaa gtgtccccca caggcctgga gcccagtcac     1080

agtctgctga gcaccgaagc caagctggtc tcagcaactg ggggcccctt gccccctgtc     1140

agcaccctga cagcactgca cagcttggag cagacctccc caggcctcaa ccaacagccc     1200

cagaatctca tcatggcctc acttcccggg gtcatggcca ttgggcctgg tgagcctgcc     1260

tccctgggcc ccacgttcac caacacgggt gcctccaccc tggtcattgg cctggcctcc     1320

actcaggccc agagcgtgcc agtcatcaac agcatgggca gcagcctgac caccctgcag     1380

ccagtccagt tctcccagcc actgcaccct tcctaccagc agccactcat gtctcccatg     1440

cagagccatg tggcccagag ccccttcatg gccaccatgg cccagattca gagcccccat     1500

gccctctaca gccacaagcc cgaggtggcc cagtacaccc acacgggcct gcttccgcag     1560

accatgctca tcaccgacac taccaacctg agcgccctgg ccagcctcac gcccaccaag     1620

caggtcttca cctcagatgc tgaggcctcc agtgagtccg ggcttcatac gccggcgtct     1680

cagaccacca ccatccacat ccccagccag gatcctgttg gcatccagca cctgcagcct     1740

gcccaccggc tcagcgccag ccccaccgtg tcctccagca gcctggtgtt gtaccagagc     1800

tccgactcca acaacggcca cagccacctg ttgccatcca accacagcgt catcgagacc     1860

ttcatttcca cgcagatggc ttcatcctcc cagtaa                               1896


<210>  6
<211>  1455
<212>  DNA
<213>  Canis lupus familiaris

<400>  6
atgcgcctct ccaaaaccct cgtcgacatg gacatggctg actacagtgc cgcgctggac       60

ccagcctaca ccacccttga gttcgagaac gtgcaggtgt tgacgatggg caatgacaca      120

tccccatccg aaggtgccaa cctcaacgca cccaacagcc tgggggtcag cgctctgtgt      180

gccatctgtg gggaccgggc cacagggaaa cactacggtg cctcgagctg tgacggttgc      240

aagggcttct tccggaggag cgtgagaaag aaccacatgt actcctgcag gtttagtcgg      300

caatgcgtcg tggacaaaga caagaggaac cagtgtcgtt actgcaggct aaagaagtgc      360

ttccgggctg gcatgaagaa ggaagctgtg caaaatgagc gggaccggat cagcactcgc      420

cggtcaagct atgaggacag cagcctgccc tccatcaatg cattgctgca ggccgaggtc      480

ctgtcccagc agatcacctc ccctgtctct gggatcaacg gagacattcg ggcgaagaag      540

atcgccagca tcgcagacgt gtgtgagtcc atgaaggagc agctgctggt gctcgttgag      600

tgggccaagt acattcctgc tttctgtgag ctcccgctgg atgaccaggt ggccctgctc      660

agagcccatg ccggtgagca cctgctactt ggagccacca agcgatccat ggtgttcaag      720

gatgttctgc ttctaggcaa tgactacatc gtccctcgcc actgcccaga gctggccgaa      780

atgagccggg tgtccatgcg catcctcgac gagttggtgc tgcccttcca ggagctacag      840

atcgatgaca atgagtatgc ctgcctcaaa gccatcatct tctttgaccc agatgccaag      900

gggctgagcg acccgggcaa gatcaagcgg ctgcgctcgc aggtgcaggt gagcctggag      960

gactacatca acgaccgcca gtatgactcc cgaggccgct tcggtgagct gctgctcctg     1020

ctgcccaccc tgcaaagcat cacctggcag atgatcgagc agatccagtt catcaagctc     1080

ttcggcatgg ccaagattga caacctgctg caggagatgt tgctgggagg tccgtgccag     1140

gcccaggagg ggctgagagg gtcctccagt gatgcacctc atgcccatca tcccctgcat     1200

cctcatctga tgcaggaaca catgggcaca aatgtcattg ttgccaacac gatgccctct     1260

cacctcagca atggacagat gtgtgagtgg ccccgaccca gggggcaggc agccacccct     1320

gagactccac agccctcgcc gccaggtggc tcagggtctg agccctacaa gctcctgcca     1380

ggagccattg ccacaatcgt caagcccccc tccgccatcc cccagccgac catcaccaag     1440

caggaagtca tctag                                                      1455


<210>  7
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Target sequence of mir-375

<400>  7
tctcgcgagc cgaacgaaca aa                                                22


<210>  8
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA for MODY3 model

<400>  8
ccuccucuuc ccaguaaccg                                                   20


<210>  9
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  sgRNA for MODY1 model

<400>  9
aagccaucua gcaagcugcu                                                   20


<210>  10
<211>  539
<212>  DNA
<213>  Artificial sequence

<220>
<223>  rat insulin promoter 1

<400>  10
cgccgggttt tgtggaagta gagatagagg agaagggacc attacatgtc ctgctgcctg       60

agttctgctt tccttctccc tttgaaggtg agctggggtc tcagctgagc taagaatcca      120

gctatcaata gaaactatga aacagttcca gggacaaaga taccaggtcc ccaacaactg      180

caactttctg ggaaatgagg tggaaagtgc tcagccaagg aaaaagaggg ccttaccctc      240

tctgggacaa tgattgtgct gtgaactgct tcatcaggcc atctggcccc ttgttaataa      300

tctaattacc ctaggtctaa gtagagttgc tgacgtccaa tgagcgcttt ctgcagactt      360

agcactaggc aagtgtttgg aaattacggc ttcggcccct ctcgccatct gcctacctac      420

ccctcctaga gcccttaatg ggccaaacgg caaagtccag ggggcagaga ggaggtgctt      480

tggactataa agctagtgga gacccagtaa ctcccaaccc taacgggata tcctcgagt       539


<210>  11
<211>  721
<212>  DNA
<213>  Artificial sequence

<220>
<223>  rat insulin promoter 2

<400>  11
gatcccccaa ccactccaag tggaggctga gaaaggtttt gtagctgggt agagtatgta       60

ctaagagatg gagacagctg gctctgagct ctgaagcaag cacctcttat ggagagttgc      120

tgaccttcag gtgcaaatct aagatactac aggagaatac accatggggc ttcagcccag      180

ttgactcccg agtgggctat gggtttgtgg aaggagagat agaagagaag ggacctttct      240

tcttgaattc tgctttcctt ctacctctga gggtgagctg gggtctcagc tgaggtgagg      300

acacagctat cagtgggaac tgtgaaacaa cagttcaagg gacaaagtta ctaggtcccc      360

caacaactgc agcctcctgg ggaatgatgt ggaaaaatgc tcagccaagg acaaagaagg      420

cctcaccctc tctgagacaa tgtcccctgc tgtgaactgg ttcatcaggc cacccaggag      480

cccctattaa gactctaatt accctaaggc taagtagagg tgttgttgtc caatgagcac      540

tttctgcaga cctagcacca ggcaagtgtt tggaaactgc agcttcagcc cctctggcca      600

tctgctgatc cacccttaat gggacaaaca gcaaagtcca ggggtcaggg ggggggtgct      660

ttggactata aagctagtgg ggattcagta acccccagcc ctaagatatc ctcgagtcta      720

g                                                                      721


<210>  12
<211>  1900
<212>  DNA
<213>  Artificial sequence

<220>
<223>  full-lenght human insulin promoter (hINS1.9)

<400>  12
ccccggccga caacactggc aaactcctac tcatccacga aggccctcct gggcatggtg       60

gtccttccca gcctggcagt ctgttcctca cacaccttgt tagtgcccag cccctgaggt      120

tgcagctggg ggtgtctctg aagggctgtg agcccccagg aagccctggg gaagtgcctg      180

ccttgcctcc ccccggccct gccagcgcct ggctctgccc tcctacctgg gctcccccca      240

tccagcctcc ctccctacac actcctctca aggaggcacc catgtcctct ccagctgccg      300

ggcctcagag cactgtggcg tcctggggca gccaccgcat gtcctgctgt ggcatggctc      360

agggtggaaa gggcggaagg gaggggtcct gcagatagct ggtgcccact accaaacccg      420

ctcggggcag gagagccaaa ggctgggtgt gtgcagagcg gccccgagag gttccgaggc      480

tgaggccagg gtgggacata gggatgcgag gggccggggc acaggatact ccaacctgcc      540

tgcccccatg gtctcatcct cctgcttctg ggacctcctg atcctgcccc tggtgctaag      600

aggcaggtag gggctgcagg cagcagggct cggagcccat gccccctcac catgggtcag      660

gctggacctc caggtgcctg ttctggggag ctgggagggc cggaggggtg taccccaggg      720

gctcagccca gatgacacta tgggggtgat ggtgtcatgg gacctggcca ggagagggga      780

gatgggctcc cagaagagga gtgggggctg agagggtgcc tggggggcca ggacggagct      840

gggccagtgc acagcttccc acacctgccc acccccagag tcctgccgcc acccccagat      900

cacacggaag atgaggtccg agtggcctgc tgaggacttg ctgcttgtcc ccaggtcccc      960

aggtcatgcc ctccttctgc caccctgggg agctgagggc ctcagctggg gctgctgtcc     1020

taaggcaggg tgggaactag gcagccagca gggaggggac ccctccctca ctcccactct     1080

cccaccccca ccaccttggc ccatccatgg cggcatcttg ggccatccgg gactggggac     1140

aggggtcctg gggacagggg tgtggggaca ggggtcctgg ggacaggggt ctggggacag     1200

gggtcctggg gacaggggtg tggggacagg ggtgtgggga caggggtgtg gggacagggg     1260

tcctggggac aggggtctgg ggacaggggt ctgaggacag gggtgtgggg acaggggtgt     1320

ggggacaggg gtgtggggac aggggtgtgg ggacaggggt ctggggacag gggtccgggg     1380

gacaggggtg tggggacagg ggtgtgggga caggggtgtg gggacagggg tctggggaca     1440

ggggtgtggg gacaggggtc ctggggacag gggtgtgggg ataggggtgt ggggacaggg     1500

gtgtggggac aggggtgtgg ggacaggggt ctggggacag cagcgcaaag agccccgccc     1560

tgcagcctcc agctctcctg gtctaatgtg gaaagtggcc caggtgaggg ctttgctctc     1620

ctggagacat ttgcccccag ctgtgagcag ggacaggtct ggccaccggg cccctggtta     1680

agactctaat gacccgctgg tcctgaggaa gaggtgctga cgaccaagga gatcttccca     1740

cagacccagc accagggaaa tggtccggaa attgcagcct cagcccccag ccatctgccg     1800

acccccccac cccaggccct aatgggccag gcggcagggg ttgagaggta ggggagatgg     1860

gctctgagac tataaagcca gcgggggccc agcagccctc                           1900


<210>  13
<211>  555
<212>  DNA
<213>  Artificial sequence

<220>
<223>  positions -385 to -1 in the human insulin promoter

<400>  13
tgtggggaca ggggtctggg gacaggggtc cgggggacag gggtgtgggg acaggggtgt       60

ggggacaggg gtgtggggac aggggtctgg ggacaggggt gtggggacag gggtcctggg      120

gacaggggtg tggggatagg ggtgtgggga caggggtgtg gggacagggg tgtggggaca      180

ggggtctggg gacagcagcg caaagagccc cgccctgcag cctccagctc tcctggtcta      240

atgtggaaag tggcccaggt gagggctttg ctctcctgga gacatttgcc cccagctgtg      300

agcagggaca ggtctggcca ccgggcccct ggttaagact ctaatgaccc gctggtcctg      360

aggaagaggt gctgacgacc aaggagatct tcccacagac ccagcaccag ggaaatggtc      420

cggaaattgc agcctcagcc cccagccatc tgccgacccc cccaccccag gccctaatgg      480

gccaggcggc aggggttgag aggtagggga gatgggctct gagactataa agccagcggg      540

ggcccagcag ccctc                                                       555


<210>  14
<211>  2730
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RIPI-HNF1A gene construct

<400>  14
cgccgggttt tgtggaagta gagatagagg agaagggacc attacatgtc ctgctgcctg       60

agttctgctt tccttctccc tttgaaggtg agctggggtc tcagctgagc taagaatcca      120

gctatcaata gaaactatga aacagttcca gggacaaaga taccaggtcc ccaacaactg      180

caactttctg ggaaatgagg tggaaagtgc tcagccaagg aaaaagaggg ccttaccctc      240

tctgggacaa tgattgtgct gtgaactgct tcatcaggcc atctggcccc ttgttaataa      300

tctaattacc ctaggtctaa gtagagttgc tgacgtccaa tgagcgcttt ctgcagactt      360

agcactaggc aagtgtttgg aaattacggc ttcggcccct ctcgccatct gcctacctac      420

ccctcctaga gcccttaatg ggccaaacgg caaagtccag ggggcagaga ggaggtgctt      480

tggactataa agctagtgga gacccagtaa ctcccaaccc taacgggatg atatcctcga      540

ggctagcgaa ttcgccacca tggtttctaa gctgagccag ctgcagacgg agctcctggc      600

tgccctgctc gagtctggcc tgagcaaaga ggccctgatc caggccttgg gggagccagg      660

gccctacctg atggttggag agggtcccct ggacaagggg gagtcctgcg gtgggagtcg      720

aggggacctg accgagttgc ctaatggcct tggagaaacg cgtggctctg aagatgacac      780

ggatgacgat ggggaagact tcgcgccacc cattctgaaa gagctggaga acctcagccc      840

agaggaggca gcccaccaga aagccgtggt ggagtcactt cttcaggagg acccatggcg      900

cgtggcgaag atggtcaagt cgtacttgca gcagcacaac atcccccagc gggaggtggt      960

ggacaccacg ggtctcaacc agtcccacct gtcacagcac ctcaacaagg gcacacccat     1020

gaagacacag aagcgggccg ctctgtacac ctggtacgtc cgcaagcagc gagaggtggc     1080

tcagcaattc acccacgcag ggcagggcgg actgattgaa gagcccacag gcgatgagct     1140

gccaactaag aaggggcgta ggaaccggtt caagtggggc cccgcatccc agcagatcct     1200

gttccaggcc tacgagaggc aaaaaaaccc cagcaaggaa gagcgagaga ccttggtgga     1260

ggagtgtaat agggcggagt gcatccagag gggggtgtca ccatcgcagg cccaggggct     1320

aggctccaac cttgtcacgg aggtgcgtgt ctacaactgg tttgccaacc ggcgcaagga     1380

ggaagccttc cggcacaagt tggccatgga cacctataac ggacctccac cggggccagg     1440

cccgggccct gcgctgcctg ctcacagttc ccccggcctg cccacaacca ccctctctcc     1500

cagtaaggtc cacggtgtac ggtacggaca gtctgcaacc agtgaggcag ccgaggtgcc     1560

ctccagcagc ggaggtccct tagtcacagt gtctgcggcc ttacaccaag tatcccccac     1620

aggcctggag cccagcagcc tgctgagcac agaggccaag ctggtctcag ccacgggggg     1680

tcccctgcct cccgtcagca ccctgacagc actgcacagc ttggagcaga catctccggg     1740

tctcaaccag cagccgcaga accttatcat ggcctcgcta cctggggtca tgaccatcgg     1800

gcccggggag cctgcctccc tgggacccac gttcacgaac acgggcgcct ccaccctggt     1860

tatcggtctg gcctccactc aggcacagag cgtgcctgtc atcaacagca tggggagtag     1920

cctgaccacg ctgcagccgg tccagttttc ccaaccactg catccctcct atcagcagcc     1980

tctcatgccc cccgtacaga gccacgtggc ccagagcccc ttcatggcaa ccatggccca     2040

gctgcagagc ccccacgcct tatacagcca caagcctgag gtggcccagt acacgcacac     2100

cagcctgctc ccgcagacca tgttgatcac agacaccaac ctcagcaccc ttgccagcct     2160

cacacccacc aagcaggtct tcacctcaga cacagaggcc tccagtgagc ccgggcttca     2220

cgagccaccc tctccagcca ccaccatcca catccccagc caggacccgt cgaacatcca     2280

gcacctgcag cctgctcacc ggctcagcac cagtcccaca gtgtcctcca gcagcctggt     2340

gttgtatcag agttccgact ccaacgggca cagccacctg ctgccatcca accatagtgt     2400

catcgagact tttatctcca cccagatggc ctcctcttcc cagtaaggta ccgcggccgc     2460

gttaacacgc gtgatatcca cgtggagctc gctgatcagc ctcgactgtg ccttctagtt     2520

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc     2580

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt     2640

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca     2700

ggcatgctgg ggatgcggtg ggctctatgg                                      2730


<210>  15
<211>  2906
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RIPII- HNF1A gene construct

<400>  15
ggatccccca accactccaa gtggaggctg agaaaggttt tgtagctggg tagagtatgt       60

actaagagat ggagacagct ggctctgagc tctgaagcaa gcacctctta tggagagttg      120

ctgaccttca ggtgcaaatc taagatacta caggagaata caccatgggg cttcagccca      180

gttgactccc gagtgggcta tgggtttgtg gaaggagaga tagaagagaa gggacctttc      240

ttcttgaatt ctgctttcct tctacctctg agggtgagct ggggtctcag ctgaggtgag      300

gacacagcta tcagtgggaa ctgtgaaaca acagttcaag ggacaaagtt actaggtccc      360

ccaacaactg cagcctcctg gggaatgatg tggaaaaatg ctcagccaag gacaaagaag      420

gcctcaccct ctctgagaca atgtcccctg ctgtgaactg gttcatcagg ccacccagga      480

gcccctatta agactctaat taccctaagg ctaagtagag gtgttgttgt ccaatgagca      540

ctttctgcag acctagcacc aggcaagtgt ttggaaactg cagcttcagc ccctctggcc      600

atctgctgat ccacccttaa tgggacaaac agcaaagtcc aggggtcagg gggggggtgc      660

tttggactat aaagctagtg gggattcagt aacccccagc cctaagatat cctcgaggct      720

agcgaattcg ccaccatggt ttctaagctg agccagctgc agacggagct cctggctgcc      780

ctgctcgagt ctggcctgag caaagaggcc ctgatccagg ccttggggga gccagggccc      840

tacctgatgg ttggagaggg tcccctggac aagggggagt cctgcggtgg gagtcgaggg      900

gacctgaccg agttgcctaa tggccttgga gaaacgcgtg gctctgaaga tgacacggat      960

gacgatgggg aagacttcgc gccacccatt ctgaaagagc tggagaacct cagcccagag     1020

gaggcagccc accagaaagc cgtggtggag tcacttcttc aggaggaccc atggcgcgtg     1080

gcgaagatgg tcaagtcgta cttgcagcag cacaacatcc cccagcggga ggtggtggac     1140

accacgggtc tcaaccagtc ccacctgtca cagcacctca acaagggcac acccatgaag     1200

acacagaagc gggccgctct gtacacctgg tacgtccgca agcagcgaga ggtggctcag     1260

caattcaccc acgcagggca gggcggactg attgaagagc ccacaggcga tgagctgcca     1320

actaagaagg ggcgtaggaa ccggttcaag tggggccccg catcccagca gatcctgttc     1380

caggcctacg agaggcaaaa aaaccccagc aaggaagagc gagagacctt ggtggaggag     1440

tgtaataggg cggagtgcat ccagaggggg gtgtcaccat cgcaggccca ggggctaggc     1500

tccaaccttg tcacggaggt gcgtgtctac aactggtttg ccaaccggcg caaggaggaa     1560

gccttccggc acaagttggc catggacacc tataacggac ctccaccggg gccaggcccg     1620

ggccctgcgc tgcctgctca cagttccccc ggcctgccca caaccaccct ctctcccagt     1680

aaggtccacg gtgtacggta cggacagtct gcaaccagtg aggcagccga ggtgccctcc     1740

agcagcggag gtcccttagt cacagtgtct gcggccttac accaagtatc ccccacaggc     1800

ctggagccca gcagcctgct gagcacagag gccaagctgg tctcagccac ggggggtccc     1860

ctgcctcccg tcagcaccct gacagcactg cacagcttgg agcagacatc tccgggtctc     1920

aaccagcagc cgcagaacct tatcatggcc tcgctacctg gggtcatgac catcgggccc     1980

ggggagcctg cctccctggg acccacgttc acgaacacgg gcgcctccac cctggttatc     2040

ggtctggcct ccactcaggc acagagcgtg cctgtcatca acagcatggg gagtagcctg     2100

accacgctgc agccggtcca gttttcccaa ccactgcatc cctcctatca gcagcctctc     2160

atgccccccg tacagagcca cgtggcccag agccccttca tggcaaccat ggcccagctg     2220

cagagccccc acgccttata cagccacaag cctgaggtgg cccagtacac gcacaccagc     2280

ctgctcccgc agaccatgtt gatcacagac accaacctca gcacccttgc cagcctcaca     2340

cccaccaagc aggtcttcac ctcagacaca gaggcctcca gtgagcccgg gcttcacgag     2400

ccaccctctc cagccaccac catccacatc cccagccagg acccgtcgaa catccagcac     2460

ctgcagcctg ctcaccggct cagcaccagt cccacagtgt cctccagcag cctggtgttg     2520

tatcagagtt ccgactccaa cgggcacagc cacctgctgc catccaacca tagtgtcatc     2580

gagactttta tctccaccca gatggcctcc tcttcccagt aaggtaccgc ggccgcgtta     2640

acacgcgtga tatccacgtg gagctcgctg atcagcctcg actgtgcctt ctagttgcca     2700

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     2760

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     2820

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     2880

tgctggggat gcggtgggct ctatgg                                          2906


<210>  16
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hIns1.9- HNF1A gene construct

<400>  16
ccccggccga caacactggc aaactcctac tcatccacga aggccctcct gggcatggtg       60

gtccttccca gcctggcagt ctgttcctca cacaccttgt tagtgcccag cccctgaggt      120

tgcagctggg ggtgtctctg aagggctgtg agcccccagg aagccctggg gaagtgcctg      180

ccttgcctcc ccccggccct gccagcgcct ggctctgccc tcctacctgg gctcccccca      240

tccagcctcc ctccctacac actcctctca aggaggcacc catgtcctct ccagctgccg      300

ggcctcagag cactgtggcg tcctggggca gccaccgcat gtcctgctgt ggcatggctc      360

agggtggaaa gggcggaagg gaggggtcct gcagatagct ggtgcccact accaaacccg      420

ctcggggcag gagagccaaa ggctgggtgt gtgcagagcg gccccgagag gttccgaggc      480

tgaggccagg gtgggacata gggatgcgag gggccggggc acaggatact ccaacctgcc      540

tgcccccatg gtctcatcct cctgcttctg ggacctcctg atcctgcccc tggtgctaag      600

aggcaggtag gggctgcagg cagcagggct cggagcccat gccccctcac catgggtcag      660

gctggacctc caggtgcctg ttctggggag ctgggagggc cggaggggtg taccccaggg      720

gctcagccca gatgacacta tgggggtgat ggtgtcatgg gacctggcca ggagagggga      780

gatgggctcc cagaagagga gtgggggctg agagggtgcc tggggggcca ggacggagct      840

gggccagtgc acagcttccc acacctgccc acccccagag tcctgccgcc acccccagat      900

cacacggaag atgaggtccg agtggcctgc tgaggacttg ctgcttgtcc ccaggtcccc      960

aggtcatgcc ctccttctgc caccctgggg agctgagggc ctcagctggg gctgctgtcc     1020

taaggcaggg tgggaactag gcagccagca gggaggggac ccctccctca ctcccactct     1080

cccaccccca ccaccttggc ccatccatgg cggcatcttg ggccatccgg gactggggac     1140

aggggtcctg gggacagggg tgtggggaca ggggtcctgg ggacaggggt ctggggacag     1200

gggtcctggg gacaggggtg tggggacagg ggtgtgggga caggggtgtg gggacagggg     1260

tcctggggac aggggtctgg ggacaggggt ctgaggacag gggtgtgggg acaggggtgt     1320

ggggacaggg gtgtggggac aggggtgtgg ggacaggggt ctggggacag gggtccgggg     1380

gacaggggtg tggggacagg ggtgtgggga caggggtgtg gggacagggg tctggggaca     1440

ggggtgtggg gacaggggtc ctggggacag gggtgtgggg ataggggtgt ggggacaggg     1500

gtgtggggac aggggtgtgg ggacaggggt ctggggacag cagcgcaaag agccccgccc     1560

tgcagcctcc agctctcctg gtctaatgtg gaaagtggcc caggtgaggg ctttgctctc     1620

ctggagacat ttgcccccag ctgtgagcag ggacaggtct ggccaccggg cccctggtta     1680

agactctaat gacccgctgg tcctgaggaa gaggtgctga cgaccaagga gatcttccca     1740

cagacccagc accagggaaa tggtccggaa attgcagcct cagcccccag ccatctgccg     1800

acccccccac cccaggccct aatgggccag gcggcagggg ttgagaggta ggggagatgg     1860

gctctgagac tataaagcca gcgggggccc agcagccctc gatatcctcg aggctagcga     1920

attcgccacc atggtttcta agctgagcca gctgcagacg gagctcctgg ctgccctgct     1980

cgagtctggc ctgagcaaag aggccctgat ccaggccttg ggggagccag ggccctacct     2040

gatggttgga gagggtcccc tggacaaggg ggagtcctgc ggtgggagtc gaggggacct     2100

gaccgagttg cctaatggcc ttggagaaac gcgtggctct gaagatgaca cggatgacga     2160

tggggaagac ttcgcgccac ccattctgaa agagctggag aacctcagcc cagaggaggc     2220

agcccaccag aaagccgtgg tggagtcact tcttcaggag gacccatggc gcgtggcgaa     2280

gatggtcaag tcgtacttgc agcagcacaa catcccccag cgggaggtgg tggacaccac     2340

gggtctcaac cagtcccacc tgtcacagca cctcaacaag ggcacaccca tgaagacaca     2400

gaagcgggcc gctctgtaca cctggtacgt ccgcaagcag cgagaggtgg ctcagcaatt     2460

cacccacgca gggcagggcg gactgattga agagcccaca ggcgatgagc tgccaactaa     2520

gaaggggcgt aggaaccggt tcaagtgggg ccccgcatcc cagcagatcc tgttccaggc     2580

ctacgagagg caaaaaaacc ccagcaagga agagcgagag accttggtgg aggagtgtaa     2640

tagggcggag tgcatccaga ggggggtgtc accatcgcag gcccaggggc taggctccaa     2700

ccttgtcacg gaggtgcgtg tctacaactg gtttgccaac cggcgcaagg aggaagcctt     2760

ccggcacaag ttggccatgg acacctataa cggacctcca ccggggccag gcccgggccc     2820

tgcgctgcct gctcacagtt cccccggcct gcccacaacc accctctctc ccagtaaggt     2880

ccacggtgta cggtacggac agtctgcaac cagtgaggca gccgaggtgc cctccagcag     2940

cggaggtccc ttagtcacag tgtctgcggc cttacaccaa gtatccccca caggcctgga     3000

gcccagcagc ctgctgagca cagaggccaa gctggtctca gccacggggg gtcccctgcc     3060

tcccgtcagc accctgacag cactgcacag cttggagcag acatctccgg gtctcaacca     3120

gcagccgcag aaccttatca tggcctcgct acctggggtc atgaccatcg ggcccgggga     3180

gcctgcctcc ctgggaccca cgttcacgaa cacgggcgcc tccaccctgg ttatcggtct     3240

ggcctccact caggcacaga gcgtgcctgt catcaacagc atggggagta gcctgaccac     3300

gctgcagccg gtccagtttt cccaaccact gcatccctcc tatcagcagc ctctcatgcc     3360

ccccgtacag agccacgtgg cccagagccc cttcatggca accatggccc agctgcagag     3420

cccccacgcc ttatacagcc acaagcctga ggtggcccag tacacgcaca ccagcctgct     3480

cccgcagacc atgttgatca cagacaccaa cctcagcacc cttgccagcc tcacacccac     3540

caagcaggtc ttcacctcag acacagaggc ctccagtgag cccgggcttc acgagccacc     3600

ctctccagcc accaccatcc acatccccag ccaggacccg tcgaacatcc agcacctgca     3660

gcctgctcac cggctcagca ccagtcccac agtgtcctcc agcagcctgg tgttgtatca     3720

gagttccgac tccaacgggc acagccacct gctgccatcc aaccatagtg tcatcgagac     3780

ttttatctcc acccagatgg cctcctcttc ccagtaaggt accgcggccg cgttaacacg     3840

cgtgatatcc acgtggagct cgctgatcag cctcgactgt gccttctagt tgccagccat     3900

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     3960

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     4020

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     4080

gggatgcggt gggctctatg g                                               4101


<210>  17
<211>  2586
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hIns385- HNF1A gene construct

<400>  17
tgtggggaca ggggtctggg gacagcagcg caaagagccc cgccctgcag cctccagctc       60

tcctggtcta atgtggaaag tggcccaggt gagggctttg ctctcctgga gacatttgcc      120

cccagctgtg agcagggaca ggtctggcca ccgggcccct ggttaagact ctaatgaccc      180

gctggtcctg aggaagaggt gctgacgacc aaggagatct tcccacagac ccagcaccag      240

ggaaatggtc cggaaattgc agcctcagcc cccagccatc tgccgacccc cccaccccag      300

gccctaatgg gccaggcggc aggggttgag aggtagggga gatgggctct gagactataa      360

agccagcggg ggcccagcag ccctcgatat cctcgaggct agcgaattcg ccaccatggt      420

ttctaagctg agccagctgc agacggagct cctggctgcc ctgctcgagt ctggcctgag      480

caaagaggcc ctgatccagg ccttggggga gccagggccc tacctgatgg ttggagaggg      540

tcccctggac aagggggagt cctgcggtgg gagtcgaggg gacctgaccg agttgcctaa      600

tggccttgga gaaacgcgtg gctctgaaga tgacacggat gacgatgggg aagacttcgc      660

gccacccatt ctgaaagagc tggagaacct cagcccagag gaggcagccc accagaaagc      720

cgtggtggag tcacttcttc aggaggaccc atggcgcgtg gcgaagatgg tcaagtcgta      780

cttgcagcag cacaacatcc cccagcggga ggtggtggac accacgggtc tcaaccagtc      840

ccacctgtca cagcacctca acaagggcac acccatgaag acacagaagc gggccgctct      900

gtacacctgg tacgtccgca agcagcgaga ggtggctcag caattcaccc acgcagggca      960

gggcggactg attgaagagc ccacaggcga tgagctgcca actaagaagg ggcgtaggaa     1020

ccggttcaag tggggccccg catcccagca gatcctgttc caggcctacg agaggcaaaa     1080

aaaccccagc aaggaagagc gagagacctt ggtggaggag tgtaataggg cggagtgcat     1140

ccagaggggg gtgtcaccat cgcaggccca ggggctaggc tccaaccttg tcacggaggt     1200

gcgtgtctac aactggtttg ccaaccggcg caaggaggaa gccttccggc acaagttggc     1260

catggacacc tataacggac ctccaccggg gccaggcccg ggccctgcgc tgcctgctca     1320

cagttccccc ggcctgccca caaccaccct ctctcccagt aaggtccacg gtgtacggta     1380

cggacagtct gcaaccagtg aggcagccga ggtgccctcc agcagcggag gtcccttagt     1440

cacagtgtct gcggccttac accaagtatc ccccacaggc ctggagccca gcagcctgct     1500

gagcacagag gccaagctgg tctcagccac ggggggtccc ctgcctcccg tcagcaccct     1560

gacagcactg cacagcttgg agcagacatc tccgggtctc aaccagcagc cgcagaacct     1620

tatcatggcc tcgctacctg gggtcatgac catcgggccc ggggagcctg cctccctggg     1680

acccacgttc acgaacacgg gcgcctccac cctggttatc ggtctggcct ccactcaggc     1740

acagagcgtg cctgtcatca acagcatggg gagtagcctg accacgctgc agccggtcca     1800

gttttcccaa ccactgcatc cctcctatca gcagcctctc atgccccccg tacagagcca     1860

cgtggcccag agccccttca tggcaaccat ggcccagctg cagagccccc acgccttata     1920

cagccacaag cctgaggtgg cccagtacac gcacaccagc ctgctcccgc agaccatgtt     1980

gatcacagac accaacctca gcacccttgc cagcctcaca cccaccaagc aggtcttcac     2040

ctcagacaca gaggcctcca gtgagcccgg gcttcacgag ccaccctctc cagccaccac     2100

catccacatc cccagccagg acccgtcgaa catccagcac ctgcagcctg ctcaccggct     2160

cagcaccagt cccacagtgt cctccagcag cctggtgttg tatcagagtt ccgactccaa     2220

cgggcacagc cacctgctgc catccaacca tagtgtcatc gagactttta tctccaccca     2280

gatggcctcc tcttcccagt aaggtaccgc ggccgcgtta acacgcgtga tatccacgtg     2340

gagctcgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct     2400

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     2460

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     2520

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     2580

ctatgg                                                                2586


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  18
tagaagagct ttccctgggc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  19
ggggtgaaga agttgaggga                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  20
ggacttggcc aacagctagt                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  21
ggaggagcag cagtgtcaat                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rplp0 forward primer

<400>  22
tcccaccttg tctccagtct                                                   20


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rplp0 reverse primer

<400>  23
actggtctag gacccgagaa g                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  L-PK forward primer

<400>  24
gtttcttggg caacaggaag                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  L-PK reverse primer

<400>  25
aggaggcaaa gatgatgtcc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HNF4a forward primer

<400>  26
agattgacaa cctgctgcag                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HNF4a reverse primer

<400>  27
tgcccatgtg ttcttgcatc                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HNF1a forward primer

<400>  28
tgtcacagca cctcaacaag                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HNF1a reverse primer

<400>  29
tgtgggctct tcaatcagtc                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Slc2a2 forward primer

<400>  30
atcccttggt tcatggttgc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Slc2a2 reverse primer

<400>  31
aattgcagac ccagttgctg                                                   20


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Atp5b forward primer

<400>  32
ggtttgaccg ttgctgaata c                                                 21


<210>  33
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Atp5b reverse primer

<400>  33
taaggcagac acctctgagc                                                   20


<210>  34
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rpl13a forward primer

<400>  34
tgaagcctac cagaaagttt gc                                                22


<210>  35
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rpl13a reverse primer

<400>  35
gcctgtttcc gtaacctcaa                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hnf4a_1 forward primer

<400>  36
gttctgtccc agcagatcac c                                                 21


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hnf4a_1 reverse primer

<400>  37
cttctttgcc cgaatgtcgc                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hnf4a_2 forward primer

<400>  38
cgtgctgctc ctaggcaatg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hnf4a_2 reverse primer

<400>  39
catcgaggat gcggatggac                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Slc2a2 forward primer

<400>  40
ggggacaaac ttggaaggat                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Slc2a2 reverse primer

<400>  41
tgaggccagc aatctgacta                                                   20


