                         SEQUENCE LISTING

<110>  Universit Brest Bretagne Occidentale et al
 
<120>  NOVEL STIM1 SPLICING VARIANTS AND USES THEREOF

<130>  B3479PC

<160>  192   

<170>  PatentIn version 3.5

<210>  1
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Val Cys Val Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu 
1               5                   10                  15      


Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Ala Thr 
            20                  25                  30          


Gly Thr Ser Ser Gly Ala Asn Ser Glu Glu Ser Thr Ala Ala Glu Phe 
        35                  40                  45              


Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser 
    50                  55                  60                  


Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn 
65                  70                  75                  80  


Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu 
                85                  90                  95      


Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp 
            100                 105                 110         


Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu 
        115                 120                 125             


Val Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp Leu Ile Thr Tyr 
    130                 135                 140                 


Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser 
145                 150                 155                 160 


Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly 
                165                 170                 175     


Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu 
            180                 185                 190         


Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His 
        195                 200                 205             


Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val 
    210                 215                 220                 


Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His 
225                 230                 235                 240 


Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln 
                245                 250                 255     


Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His 
            260                 265                 270         


Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp 
        275                 280                 285             


Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg 
    290                 295                 300                 


Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu 
305                 310                 315                 320 


Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu 
                325                 330                 335     


Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln 
            340                 345                 350         


Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn 
        355                 360                 365             


Ala Glu Lys Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys 
    370                 375                 380                 


Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Asn Ser Leu Ser 
                405                 410                 415     


Ser Val Phe Arg Gln Ala Leu Ser Glu Val Thr Ala Ala Leu Arg Glu 
            420                 425                 430         


Arg Leu His Arg Trp Gln Gln Ile Glu Ile Leu Cys Gly Phe Gln Ile 
        435                 440                 445             


Val Asn Asn Pro Gly Ile His Ser Leu Val Ala Ala Leu Asn Ile Asp 
    450                 455                 460                 


Pro Ser Trp Met Gly Ser Thr Arg Pro Asn Pro Ala His Phe Ile Met 
465                 470                 475                 480 


Thr Asp Asp Val Asp Asp Met Asp Glu Glu Ile Val Ser Pro Leu Ser 
                485                 490                 495     


Met Gln Ser Pro Ser Leu Gln Ser Ser Val Arg Gln Arg Leu Thr Glu 
            500                 505                 510         


Pro Gln His Gly Leu Gly Ser Gln Arg Asp Leu Thr His Ser Asp Ser 
        515                 520                 525             


Glu Ser Ser Leu His Met Ser Asp Arg Gln Arg Val Ala Pro Lys Pro 
    530                 535                 540                 


Pro Gln Met Ser Arg Ala Ala Asp Glu Ala Leu Asn Ala Met Thr Ser 
545                 550                 555                 560 


Asn Gly Ser His Arg Leu Ile Glu Gly Val His Pro Gly Ser Leu Val 
                565                 570                 575     


Glu Lys Leu Pro Asp Ser Pro Ala Leu Ala Lys Lys Ala Leu Leu Ala 
            580                 585                 590         


Leu Asn His Gly Leu Asp Lys Ala His Ser Leu Met Glu Leu Ser Pro 
        595                 600                 605             


Ser Ala Pro Pro Gly Gly Ser Pro His Leu Asp Ser Ser Arg Ser His 
    610                 615                 620                 


Ser Pro Ser Ser Pro Asp Pro Asp Thr Pro Ser Pro Val Gly Asp Ser 
625                 630                 635                 640 


Arg Ala Leu Gln Ala Ser Arg Asn Thr Arg Ile Pro His Leu Ala Gly 
                645                 650                 655     


Lys Lys Ala Val Ala Glu Glu Asp Asn Gly Ser Ile Gly Glu Glu Thr 
            660                 665                 670         


Asp Ser Ser Pro Gly Arg Lys Lys Phe Pro Leu Lys Ile Phe Lys Lys 
        675                 680                 685             


Pro Leu Lys Lys 
    690         


<210>  2
<211>  2079
<212>  DNA
<213>  Homo sapiens

<400>  2
atggatgtat gcgtccgtct tgccctgtgg ctcctctggg gactcctcct gcaccagggc       60

cagagcctca gccatagtca cagtgagaag gcgacaggaa ccagctcggg ggccaactct      120

gaggagtcca ctgcagcaga gttttgccga attgacaagc ccctgtgtca cagtgaggat      180

gagaaactca gcttcgaggc agtccgtaac atccacaaac tgatggacga tgatgccaat      240

ggtgatgtgg atgtggaaga aagtgatgag ttcctgaggg aagacctcaa ttaccatgac      300

ccaacagtga aacacagcac cttccatggt gaggataagc tcatcagcgt ggaggacctg      360

tggaaggcat ggaagtcatc agaagtatac aattggaccg tggatgaggt ggtacagtgg      420

ctgatcacat atgtggagct gcctcagtat gaggagacct tccggaagct gcagctcagt      480

ggccatgcca tgccaaggct ggctgtcacc aacaccacca tgacagggac tgtgctgaag      540

atgacagacc ggagtcatcg gcagaagctg cagctgaagg ctctggatac agtgctcttt      600

gggcctcctc tcttgactcg ccataatcac ctcaaggact tcatgctggt ggtgtctatc      660

gttattggtg tgggcggctg ctggtttgcc tatatccaga accgttactc caaggagcac      720

atgaagaaga tgatgaagga cttggagggg ttacaccgag ctgagcagag tctgcatgac      780

cttcaggaaa ggctgcacaa ggcccaggag gagcaccgca cagtggaggt ggagaaggtc      840

catctggaaa agaagctgcg cgatgagatc aaccttgcta agcaggaagc ccagcggctg      900

aaggagctgc gggagggtac tgagaatgag cggagccgcc aaaaatatgc tgaggaggag      960

ttggagcagg ttcgggaggc cttgaggaaa gcagagaagg agctagaatc tcacagctca     1020

tggtatgctc cagaggccct tcagaagtgg ctgcagctga cacatgaggt ggaggtgcaa     1080

tattacaaca tcaagaagca aaatgctgag aagcagctgc tggtggccaa ggagggggct     1140

gagaagataa aaaagaagag aaacacactc tttggcacct tccacgtggc ccacagctct     1200

tccctggatg atgtagatca taaaattcta acagctaatt ctctttcctc tgtcttcagg     1260

caagcactga gcgaggtgac agcagcattg cgggagcgcc tgcaccgctg gcaacagatc     1320

gagatcctct gtggcttcca gattgtcaac aaccctggca tccactcact ggtggctgcc     1380

ctcaacatag accccagctg gatgggcagt acacgcccca accctgctca cttcatcatg     1440

actgacgacg tggatgacat ggatgaggag attgtgtctc ccttgtccat gcagtcccct     1500

agcctgcaga gcagtgttcg gcagcgcctg acggagccac agcatggcct gggatctcag     1560

agggatttga cccattccga ttcggagtcc tccctccaca tgagtgaccg ccagcgtgtg     1620

gcccccaaac ctcctcagat gagccgtgct gcagacgagg ctctcaatgc catgacttcc     1680

aatggcagcc accggctgat cgagggggtc cacccagggt ctctggtgga gaaactgcct     1740

gacagccctg ccctggccaa gaaggcatta ctggcgctga accatgggct ggacaaggcc     1800

cacagcctga tggagctgag cccctcagcc ccacctggtg gctctccaca tttggattct     1860

tcccgttctc acagccccag ctccccagac ccagacacac catctccagt tggggacagc     1920

cgagccctgc aagccagccg aaacacacgc attccccacc tggctggcaa gaaggctgtg     1980

gctgaggagg ataatggctc tattggcgag gaaacagact ccagcccagg ccggaagaag     2040

tttcccctca aaatctttaa gaagcctctt aagaagtag                            2079


<210>  3
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  aa 411-420 of STIM1ins

<400>  3

Ala Asn Ser Leu Ser Ser Val Phe Arg Gln Ala 
1               5                   10      


<210>  4
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  residues 1231-1260 of SEQ ID No 2

<400>  4
gctaattctc tttcctctgt cttcaggcaa gca                                    33


<210>  5
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Val Cys Val Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu 
1               5                   10                  15      


Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Ala Thr 
            20                  25                  30          


Gly Thr Ser Ser Gly Ala Asn Ser Glu Glu Ser Thr Ala Ala Glu Phe 
        35                  40                  45              


Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser 
    50                  55                  60                  


Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn 
65                  70                  75                  80  


Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu 
                85                  90                  95      


Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp 
            100                 105                 110         


Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu 
        115                 120                 125             


Val Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp Leu Ile Thr Tyr 
    130                 135                 140                 


Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser 
145                 150                 155                 160 


Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly 
                165                 170                 175     


Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu 
            180                 185                 190         


Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His 
        195                 200                 205             


Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val 
    210                 215                 220                 


Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His 
225                 230                 235                 240 


Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln 
                245                 250                 255     


Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His 
            260                 265                 270         


Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp 
        275                 280                 285             


Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg 
    290                 295                 300                 


Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu 
305                 310                 315                 320 


Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu 
                325                 330                 335     


Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln 
            340                 345                 350         


Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn 
        355                 360                 365             


Ala Glu Lys Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys 
    370                 375                 380                 


Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu 
                405                 410                 415     


Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln 
            420                 425                 430         


Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His 
        435                 440                 445             


Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr 
    450                 455                 460                 


Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met 
465                 470                 475                 480 


Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln 
                485                 490                 495     


Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser 
            500                 505                 510         


Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser 
        515                 520                 525             


Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Ser Arg Ala Ala 
    530                 535                 540                 


Asp Glu Ala Leu Asn Ala Met Thr Ser Asn Gly Ser His Arg Leu Ile 
545                 550                 555                 560 


Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro 
                565                 570                 575     


Ala Leu Ala Lys Lys Ala Leu Leu Ala Leu Asn His Gly Leu Asp Lys 
            580                 585                 590         


Ala His Ser Leu Met Glu Leu Ser Pro Ser Ala Pro Pro Gly Gly Ser 
        595                 600                 605             


Pro His Leu Asp Ser Ser Arg Ser His Ser Pro Ser Ser Pro Asp Pro 
    610                 615                 620                 


Asp Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Ala Ser Arg 
625                 630                 635                 640 


Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Val Ala Glu Glu 
                645                 650                 655     


Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys 
            660                 665                 670         


Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys 
        675                 680                 685 


<210>  6
<211>  2058
<212>  DNA
<213>  Homo sapiens

<400>  6
atggatgtat gcgtccgtct tgccctgtgg ctcctctggg gactcctcct gcaccagggc       60

cagagcctca gccatagtca cagtgagaag gcgacaggaa ccagctcggg ggccaactct      120

gaggagtcca ctgcagcaga gttttgccga attgacaagc ccctgtgtca cagtgaggat      180

gagaaactca gcttcgaggc agtccgtaac atccacaaac tgatggacga tgatgccaat      240

ggtgatgtgg atgtggaaga aagtgatgag ttcctgaggg aagacctcaa ttaccatgac      300

ccaacagtga aacacagcac cttccatggt gaggataagc tcatcagcgt ggaggacctg      360

tggaaggcat ggaagtcatc agaagtatac aattggaccg tggatgaggt ggtacagtgg      420

ctgatcacat atgtggagct gcctcagtat gaggagacct tccggaagct gcagctcagt      480

ggccatgcca tgccaaggct ggctgtcacc aacaccacca tgacagggac tgtgctgaag      540

atgacagacc ggagtcatcg gcagaagctg cagctgaagg ctctggatac agtgctcttt      600

gggcctcctc tcttgactcg ccataatcac ctcaaggact tcatgctggt ggtgtctatc      660

gttattggtg tgggcggctg ctggtttgcc tatatccaga accgttactc caaggagcac      720

atgaagaaga tgatgaagga cttggagggg ttacaccgag ctgagcagag tctgcatgac      780

cttcaggaaa ggctgcacaa ggcccaggag gagcaccgca cagtggaggt ggagaaggtc      840

catctggaaa agaagctgcg cgatgagatc aaccttgcta agcaggaagc ccagcggctg      900

aaggagctgc gggagggtac tgagaatgag cggagccgcc aaaaatatgc tgaggaggag      960

ttggagcagg ttcgggaggc cttgaggaaa gcagagaagg agctagaatc tcacagctca     1020

tggtatgctc cagaggccct tcagaagtgg ctgcagctga cacatgaggt ggaggtgcaa     1080

tattacaaca tcaagaagca aaatgctgag aagcagctgc tggtggccaa ggagggggct     1140

gagaagataa aaaagaagag aaacacactc tttggcacct tccacgtggc ccacagctct     1200

tccctggatg atgtagatca taaaattcta acagctaagc aagcactgag cgaggtgaca     1260

gcagcattgc gggagcgcct gcaccgctgg caacagatcg agatcctctg tggcttccag     1320

attgtcaaca accctggcat ccactcactg gtggctgccc tcaacataga ccccagctgg     1380

atgggcagta cacgccccaa ccctgctcac ttcatcatga ctgacgacgt ggatgacatg     1440

gatgaggaga ttgtgtctcc cttgtccatg cagtccccta gcctgcagag cagtgttcgg     1500

cagcgcctga cggagccaca gcatggcctg ggatctcaga gggatttgac ccattccgat     1560

tcggagtcct ccctccacat gagtgaccgc cagcgtgtgg cccccaaacc tcctcagatg     1620

agccgtgctg cagacgaggc tctcaatgcc atgacttcca atggcagcca ccggctgatc     1680

gagggggtcc acccagggtc tctggtggag aaactgcctg acagccctgc cctggccaag     1740

aaggcattac tggcgctgaa ccatgggctg gacaaggccc acagcctgat ggagctgagc     1800

ccctcagccc cacctggtgg ctctccacat ttggattctt cccgttctca cagccccagc     1860

tccccagacc cagacacacc atctccagtt ggggacagcc gagccctgca agccagccga     1920

aacacacgca ttccccacct ggctggcaag aaggctgtgg ctgaggagga taatggctct     1980

attggcgagg aaacagactc cagcccaggc cggaagaagt ttcccctcaa aatctttaag     2040

aagcctctta agaagtag                                                   2058


<210>  7
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  7
ttctctttcc tctgtcttca ggcaagcact gagcgaggtg ac                          42


<210>  8
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  8
ttagctgtta gaattttatg atctacatca tcc                                    33


<210>  9
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  9
cactctttgg caccttccac                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  10
gacaatctgg aagccacaga g                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  11
ctgacacatg aggtggaggt g                                                 21


<210>  12
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  12
gcctgaagac agaggaaaga gaac                                              24


<210>  13
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  13
gtgaaacaca gcaccttcca                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  14
cactgtacca cctcatccac g                                                 21


<210>  15
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  15
gacgacgtgg atgacatgga                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  16
gatggtgtgt ctgggtctgg                                                   20


<210>  17
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  17
gggcgagggc agctc                                                        15


<210>  18
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
aggagcagag gggtcgatag                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  19
cacctctaac caccactcgg                                                   20


<210>  20
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
cgggtactgg tactgcgtc                                                    19


<210>  21
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
cgccaagctt aaagcctcca                                                   20


<210>  22
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  22
ctgatcatga gcgcaaacag g                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  23
gacacctcgc agtcattcct                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  24
tgatcccacc agaagcaacc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  25
gggtgctgat ctccaggatg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  26
ggaggttggc tcctcaatcc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  27
gagtcaacgg atttggtcgt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  28
ttgattttgg agggatctcg                                                   20


<210>  29
<211>  13
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Fig1A STIM1pre-mRNA first part

<400>  29
gtaagtaaca cca                                                          13


<210>  30
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  Fig1A STIM1pre-mRNA second part

<400>  30
caagtccatg cctgcagttc tctttcctct gtcttcag                               38


<210>  31
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  STIM1insmRNA

<400>  31
ttctctttcc tctgtcttca g                                                 21


<210>  32
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  peptide for immunization

<400>  32

Cys Thr Ala Asn Ser Leu Ser Ser Phe Arg Gln Ala 
1               5                   10          


<210>  33
<211>  114
<212>  PRT
<213>  artificial

<220>
<223>  1E05 VH

<400>  33

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  34
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  1E05 VL

<400>  34

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Gly Arg Phe Thr Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  35
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  1F02 VH

<400>  35

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Tyr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Ala Trp Ile Asn Thr Lys Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      


Ala Asn Leu Gly Gly Gly Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  36
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  1F02 VL

<400>  36

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Thr Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Val Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  37
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  2F12 VH

<400>  37

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ser Ser Val Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Phe Phe Cys 
                85                  90                  95      


Val Ser Pro Thr Gly Thr Gly Asp Phe Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  38
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  2F12 VL

<400>  38

Asp Ala Val Met Thr Gln Ser Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  4B05 VH

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Gly Gly Asp Gly Phe Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  40
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  4B05 VL

<400>  40

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Arg Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Lys His Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  41
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  8E11 VH

<400>  41

Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asp Ser 
            20                  25                  30          


Val Ile Thr Trp Val Lys Gln Arg Ile Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Ser Ile Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Ile Gln Leu Gly Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Asn Asn Tyr Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  42
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  8E11 VL

<400>  42

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  43
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  15G09 VH

<400>  43

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Ala Ser Ala His Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Val Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Pro Thr Gly Lys Gly Asp Tyr Trp Gly Arg Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  44
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  15G09 VL

<400>  44

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  45
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  15H01 VH

<400>  45

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Asp Gly Gly Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  46
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  15H01 VL

<400>  46

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Met Tyr Ser Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  47
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  16A08 VH

<400>  47

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Lys Gln Ala Pro Gly Lys Ala Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Pro Arg Phe Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ser Arg Ala Tyr Gly Asp Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  48
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  16A08 VL

<400>  48

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  49
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  49

Asp Tyr Tyr Met His 
1               5   


<210>  50
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  50

Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  51

Asp Gly Phe Asp Tyr 
1               5   


<210>  52
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  52

Gly Phe Asn Ile Lys Asp Tyr 
1               5           


<210>  53
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  53

Asp Pro Glu Asn Gly Asn 
1               5       


<210>  54
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  54

Asp Gly Phe Asp Tyr 
1               5   


<210>  55
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  55

Gly Phe Asn Ile Lys Asp Tyr Tyr 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  56

Ile Asp Pro Glu Asn Gly Asn Thr 
1               5               


<210>  57
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  57

Ala Met Asp Gly Phe Asp Tyr 
1               5           


<210>  58
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  58

Asn Tyr Gly Met Tyr 
1               5   


<210>  59
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  59

Trp Ile Asn Thr Lys Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  60

Leu Gly Gly Gly Tyr Phe Asp Val 
1               5               


<210>  61
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  61

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  62
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  62

Asn Thr Lys Thr Gly Glu 
1               5       


<210>  63
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  63

Leu Gly Gly Gly Tyr Phe Asp Val 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  64

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  65

Ile Asn Thr Lys Thr Gly Glu Pro 
1               5               


<210>  66
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  66

Ala Asn Leu Gly Gly Gly Tyr Phe Asp Val 
1               5                   10  


<210>  67
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  67

Asp Tyr Ala Met His 
1               5   


<210>  68
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  68

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  69

Pro Thr Gly Thr Gly Asp Phe 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  70

Val Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  71
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  71

Asn Thr Glu Thr Gly Glu 
1               5       


<210>  72
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  72

Pro Thr Gly Thr Gly Asp Phe 
1               5           


<210>  73
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  73

Val Tyr Thr Phe Thr Asp Tyr Ala 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  74

Ile Asn Thr Glu Thr Gly Glu Pro 
1               5               


<210>  75
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  75

Val Ser Pro Thr Gly Thr Gly Asp Phe 
1               5                   


<210>  76
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  76

Ser Tyr Gly Met Ser 
1               5   


<210>  77
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  77

Thr Ile Thr Gly Gly Asp Gly Phe Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  78

Ser Asp Tyr 
1           


<210>  79
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  79

Gly Phe Thr Phe Asn Ser Tyr 
1               5           


<210>  80
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  80

Thr Gly Gly Asp Gly Phe 
1               5       


<210>  81
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  81

Ser Asp Tyr 
1           


<210>  82
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  82

Gly Phe Thr Phe Asn Ser Tyr Gly 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  83

Ile Thr Gly Gly Asp Gly Phe Thr 
1               5               


<210>  84
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  84

Thr Arg Ser Asp Tyr 
1               5   


<210>  85
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  85

Asp Ser Val Ile Thr 
1               5   


<210>  86
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  86

Glu Ile Tyr Pro Gly Ser Gly Ser Ile Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  87

Asn Tyr Asn Gly Met Asp Tyr 
1               5           


<210>  88
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  88

Gly Tyr Ile Phe Ser Asp Ser 
1               5           


<210>  89
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  89

Tyr Pro Gly Ser Gly Ser 
1               5       


<210>  90
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  90

Asn Tyr Asn Gly Met Asp Tyr 
1               5           


<210>  91
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  91

Gly Tyr Ile Phe Ser Asp Ser Val 
1               5               


<210>  92
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  92

Ile Tyr Pro Gly Ser Gly Ser Ile 
1               5               


<210>  93
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  93

Ala Asn Asn Tyr Asn Gly Met Asp Tyr 
1               5                   


<210>  94
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  94

Asn Phe Gly Met Asn 
1               5   


<210>  95
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  95

Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  96

Pro Thr Gly Lys Gly Asp Tyr 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  97

Gly Tyr Ile Phe Ser Asn Phe 
1               5           


<210>  98
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  98

Asn Thr Asn Thr Gly Glu 
1               5       


<210>  99
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  99

Pro Thr Gly Lys Gly Asp Tyr 
1               5           


<210>  100
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  100

Gly Tyr Ile Phe Ser Asn Phe Gly 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  101

Ile Asn Thr Asn Thr Gly Glu Pro 
1               5               


<210>  102
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  102

Val Arg Pro Thr Gly Lys Gly Asp Tyr 
1               5                   


<210>  103
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  103

Asp Tyr Gly Met Asp 
1               5   


<210>  104
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  104

Asn Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  105

Pro Tyr Asp Gly Gly Asp Tyr 
1               5           


<210>  106
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  106

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  107
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  107

Asn Pro Asn Asn Gly Gly 
1               5       


<210>  108
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  108

Pro Tyr Asp Gly Gly Asp Tyr 
1               5           


<210>  109
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  109

Gly Tyr Thr Phe Thr Asp Tyr Gly 
1               5               


<210>  110
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  110

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  111
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  111

Ala Ser Pro Tyr Asp Gly Gly Asp Tyr 
1               5                   


<210>  112
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  112

Asn Tyr Gly Met His 
1               5   


<210>  113
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  113

Trp Ile Asn Thr Lys Thr Gly Glu Pro Arg Phe Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  114

Ala Tyr Gly Asp Tyr Pro Tyr 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  115

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  116
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  116

Asn Thr Lys Thr Gly Glu 
1               5       


<210>  117
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  117

Ala Tyr Gly Asp Tyr Pro Tyr 
1               5           


<210>  118
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR1

<400>  118

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  119
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  HCDR2

<400>  119

Ile Asn Thr Lys Thr Gly Glu Pro 
1               5               


<210>  120
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  HCDR3

<400>  120

Ser Arg Ala Tyr Gly Asp Tyr Pro Tyr 
1               5                   


<210>  121
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  121

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  122
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  122

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  123
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  123

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  124
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  124

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  125
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  125

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  126
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  126

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  127
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  127

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  128
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  128

Leu Val Ser 
1           


<210>  129
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  129

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  130
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  130

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  131
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  131

Val Val Ser Lys Leu Asp Ser 
1               5           


<210>  132
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  132

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  133
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  133

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  134
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  134

Val Val Ser Lys Leu Asp Ser 
1               5           


<210>  135
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  135

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  136
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  136

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  137
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  137

Val Val Ser 
1           


<210>  138
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  138

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  139
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  139

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  140
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  140

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  141
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  141

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  142
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  142

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  143
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  143

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  144
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  144

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  145
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  145

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  146
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  146

Leu Val Ser 
1           


<210>  147
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  147

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  148
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  148

Lys Ser Ser Arg Ser Leu Leu Asp Thr Asp Gly Glu Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  149
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  149

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  150
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  150

Trp Gln Gly Lys His Ser Pro Trp Thr 
1               5                   


<210>  151
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  151

Lys Ser Ser Arg Ser Leu Leu Asp Thr Asp Gly Glu Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  152
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  152

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  153
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  153

Trp Gln Gly Lys His Ser Pro Trp Thr 
1               5                   


<210>  154
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  154

Arg Ser Leu Leu Asp Thr Asp Gly Glu Thr Tyr 
1               5                   10      


<210>  155
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  155

Leu Val Ser 
1           


<210>  156
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  156

Trp Gln Gly Lys His Ser Pro Trp Thr 
1               5                   


<210>  157
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  157

Lys Ser Ser Gln Ser Leu Leu Asp Ser Ser Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  158
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  158

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  159
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  159

Val Gln Gly Thr His Phe Pro Phe Thr 
1               5                   


<210>  160
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  160

Lys Ser Ser Gln Ser Leu Leu Asp Ser Ser Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  161
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  161

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  162
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  162

Val Gln Gly Thr His Phe Pro Phe Thr 
1               5                   


<210>  163
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  163

Gln Ser Leu Leu Asp Ser Ser Gly Lys Thr Tyr 
1               5                   10      


<210>  164
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  164

Leu Val Ser 
1           


<210>  165
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  165

Val Gln Gly Thr His Phe Pro Phe Thr 
1               5                   


<210>  166
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  166

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  167
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  167

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  168
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  168

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  169
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  169

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  170
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  170

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  171
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  171

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  172
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  172

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  173
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  173

Leu Val Ser 
1           


<210>  174
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  174

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  175
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  175

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  176
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  176

Ser Val Ser Lys Leu Asp Ser 
1               5           


<210>  177
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  177

Val Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  178
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  178

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  179
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  179

Ser Val Ser Lys Leu Asp Ser 
1               5           


<210>  180
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  180

Val Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  181
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  181

Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr 
1               5                   10      


<210>  182
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  182

Ser Val Ser 
1           


<210>  183
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  183

Val Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  184
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  184

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  185
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  185

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  186
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  186

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  187
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  187

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  188
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  188

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  189
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  189

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  190
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  LCDR1

<400>  190

Gln Ser Leu Leu Tyr Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  191
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  LCDR2

<400>  191

Leu Val Ser 
1           


<210>  192
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  LCDR3

<400>  192

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


