                         SEQUENCE LISTING

<110>  ETH Zurich
       Institute for Research in Biomedicine
 
<120>  ANTIBODIES BROADLY TARGETING CORONAVIRUSES AND USES THEREOF

<130>  ET04P001WO

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 epitope

<400>  1

Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-1 epitope

<400>  2

Lys Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MERS epitope

<400>  3

Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp Lys 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OC43 epitope

<400>  4

Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp Lys 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HKU1 epitope

<400>  5

Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp Leu Leu Phe Asn Lys 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NL63 epitope

<400>  6

Arg Ile Ala Gly Arg Ser Ala Leu Glu Asp Leu Leu Phe Ser Lys 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  229E epitope

<400>  7

Arg Val Ala Gly Arg Ser Ala Ile Glu Asp Ile Leu Phe Ser Lys 
1               5                   10                  15  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  8

Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRH1

<400>  9

Gly Asp Ser Ile Ser Asn Glu Asp Tyr His 
1               5                   10  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRH2

<400>  10

Leu Gln Tyr Ser Gly Asn Thr 
1               5           


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRH3

<400>  11

Ala Thr Ser Ile Val Leu Thr Gly Met Ser Asn Lys Ile Gln Pro Phe 
1               5                   10                  15      


Asp Tyr 
        


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRL1

<400>  12

Ala Leu Pro Lys Lys Tyr 
1               5       


<210>  13

<400>  13
000

<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRL2 long

<400>  14

Val Ile Tyr Lys Asp Thr Glu Arg Pro 
1               5                   


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRL3

<400>  15

Leu Ser Ala Asp Thr Ser Gly Thr Trp Val 
1               5                   10  


<210>  16
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 VH

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Asn Glu 
            20                  25                  30          


Asp Tyr His Trp Thr Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Tyr Leu Gln Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Met Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Thr Ser Ile Val Leu Thr Gly Met Ser Asn Lys Ile Gln Pro 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 VL

<400>  17

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Met Ala Arg Ile Thr Cys Ser Gly Glu Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Gly Gly Gln Phe Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Ile Val Thr Leu Thr Ile Ser Gly Val Gln Pro Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Thr Ser Gly Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  18
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_A7 VH

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Asn Glu 
            20                  25                  30          


Asp Tyr His Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Tyr Leu Gln Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Met Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Thr Ser Ile Val Leu Thr Gly Met Ser Asn Lys Ile Gln Pro 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_A7 VL

<400>  19

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Met Ala Arg Ile Thr Cys Ser Gly Glu Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ala Gly Gln Phe Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Ile Val Thr Leu Thr Ile Ser Gly Val Gln Pro Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Thr Ser Gly Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRH1

<400>  20

Gly Phe Thr Ser Lys Asn Thr Ala 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRH2

<400>  21

Ile Asp Ile Ser Asn Tyr Ile Thr 
1               5               


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRH3

<400>  22

Ala Ala Val Gly Lys Asp Asp Asp Val Leu Thr Gly Gly Asn Lys Tyr 
1               5                   10                  15      


Phe Asp His 
            


<210>  23

<400>  23
000

<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRL2 long

<400>  24

Val Ile His Glu Asp Asp Lys Arg Pro 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRL3

<400>  25

Tyr Ser Thr Asp Thr Asn Asp Asn His Ala 
1               5                   10  


<210>  26
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 VH

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Ala Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Ser Lys Asn Thr 
            20                  25                  30          


Ala Leu Gln Trp Val Arg Gln Ala Arg Gly Gln Pro Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Ile Ser Asn Tyr Ile Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Leu Thr Ile Thr Trp Asp Leu Ser Ala Ser Met Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Gly Lys Asp Asp Asp Val Leu Thr Gly Gly Asn Lys Tyr 
            100                 105                 110         


Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 VL

<400>  27

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile His 
        35                  40                  45              


Glu Asp Asp Lys Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser Ala Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Thr Asn Asp Asn His 
                85                  90                  95      


Ala Phe Gly Ser Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRH1

<400>  28

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr 
1               5                   10  


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRH2

<400>  29

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRH3

<400>  30

Ala Thr Ser Ile Val Leu Ser Gly Met Ser Asn Lys Ile Gln Pro Phe 
1               5                   10                  15      


Asp Tyr 
        


<210>  31

<400>  31
000

<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRL2 long

<400>  32

Val Ile Tyr Lys Asp Ser Glu Arg Pro 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRL3

<400>  33

Leu Ser Ala Asp Ser Ser Gly Thr Trp Val 
1               5                   10  


<210>  34
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA VH

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Ser Ile Val Leu Ser Gly Met Ser Asn Lys Ile Gln Pro 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  35
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA VL

<400>  35

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Met Ala Arg Ile Thr Cys Ser Gly Glu Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Phe Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Ile Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Ser Ser Gly Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105     


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRH1

<400>  36

Gly Phe Asn Phe Ser Ser His Gly 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRH2

<400>  37

Ile Ser Phe His Gly Thr His Pro 
1               5               


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRH3

<400>  38

Ala Lys Asp Val Val Leu Arg Tyr Phe Asp Ala Met Asp Val 
1               5                   10                  


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRL1

<400>  39

Ser Thr Gly Val Gly Ser His Asn Leu 
1               5                   


<210>  40

<400>  40
000

<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRL2 long

<400>  41

Ile Ile Tyr Glu Val Thr Lys Arg Pro 
1               5                   


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRL3

<400>  42

Cys Ser Tyr Ala Gly Thr Gly Asn Ser Trp Val 
1               5                   10      


<210>  43
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 VH

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Val Ala Ser Gly Phe Asn Phe Ser Ser His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Phe His Gly Thr His Pro Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gly Pro Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Val Val Leu Arg Tyr Phe Asp Ala Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Ile Ser Ser 
        115                 120     


<210>  44
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 VL

<400>  44

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Ala Ser Thr Gly Val Gly Ser His 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Thr Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr His Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Gly Asn Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRH1

<400>  45

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRH2

<400>  46

Ile Ser Tyr His Gly Thr His Pro 
1               5               


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRH3

<400>  47

Ala Lys Asp Leu Val Leu Arg Tyr Phe Asp Ser Met Asp Val 
1               5                   10                  


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRL1

<400>  48

Ser Ser Gly Val Gly Ser His Asp Leu 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRL2 long

<400>  49

Met Ile Tyr Glu Val Thr Arg Arg Pro 
1               5                   


<210>  50
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 VH

<400>  50

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr His Gly Thr His Pro Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Gly Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Val Leu Arg Tyr Phe Asp Ser Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  51
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 VL

<400>  51

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Gly Val Gly Ser His 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Thr Arg Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr His Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Gly Asn Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 CDRH1

<400>  52

Gly Phe Ser Phe Ser Ser Tyr Gly 
1               5               


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 CDRL1

<400>  53

Ser Ser Gly Val Gly Ser His Asn Leu 
1               5                   


<210>  54
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 VH

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Phe His Gly Thr His Pro Phe Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Asp Met Gly Ser Leu Gly Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Val Val Leu Arg Tyr Phe Asp Ala Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Ser Thr Val Thr Val Ser Ser 
        115                 120     


<210>  55
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 VL

<400>  55

Gln Ala Gly Gln Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Ala Ser Ser Gly Val Gly Ser His 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr His Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Gly Asn Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRH1

<400>  56

Gly Phe Thr Phe Ser Arg Tyr Trp 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRH2

<400>  57

Thr Ser Gly Asp Gly Ser Ile Thr 
1               5               


<210>  58
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRH3

<400>  58

Ala Arg Ala Leu Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Val Asn Trp 
1               5                   10                  15      


Phe Asp Pro 
            


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRL1

<400>  59

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  60

<400>  60
000

<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRL2 long

<400>  61

Leu Ile Tyr Ala Ser Thr Asn Arg Pro 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRL3

<400>  62

Gln Ser Tyr Asp Ile Ser Leu Glu Val 
1               5                   


<210>  63
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 VH

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Thr Ser Gly Asp Gly Ser Ile Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Val Asn Trp 
            100                 105                 110         


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  64
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 VL

<400>  64

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ser Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ile Ser 
                85                  90                  95      


Leu Glu Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRH1

<400>  65

Gly Phe Thr Phe Asn Asn Tyr Ala 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRH2

<400>  66

Ile Ser Tyr Glu Gly Ser Leu Lys 
1               5               


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRH3

<400>  67

Ala Arg Ser His Gly Leu Phe Glu Leu Pro Pro Phe Tyr Leu Asp Tyr 
1               5                   10                  15      


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRL1

<400>  68

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRL2 long

<400>  69

Met Ile Tyr Glu Val Thr Asn Arg Pro 
1               5                   


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRL3

<400>  70

Ser Ser Phe Thr Ser Arg Ser Thr His Val 
1               5                   10  


<210>  71
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 VH

<400>  71

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Arg Ile Ser Tyr Glu Gly Ser Leu Lys Ser Tyr Ala Glu Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met His Ser Leu Thr Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser His Gly Leu Phe Glu Leu Pro Pro Phe Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Tyr Ser 
        115                 120         


<210>  72
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 VL

<400>  72

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Met Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Thr Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Thr Ser Arg 
                85                  90                  95      


Ser Thr His Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  73
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region

<400>  73

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  74
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lambda light chain constant region

<400>  74

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  75
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  kappa light chain constant region

<400>  75

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  76
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRH1

<400>  76
ggtgactcca tcagcaacga ggattaccac                                        30


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRH2

<400>  77
ctccagtaca gtgggaacac c                                                 21


<210>  78
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRH3

<400>  78
gcgaccagta tagtactgac tgggatgtcg aacaagatcc agccctttga ctac             54


<210>  79
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRL1

<400>  79
gcattgccaa aaaaatat                                                     18


<210>  80

<400>  80
000

<210>  81
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRL2 long

<400>  81
gtgatatata aagacaccga gaggccc                                           27


<210>  82
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 CDRL3

<400>  82
ctatcagcag acaccagtgg tacttgggtg                                        30


<210>  83
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 VH

<400>  83
caggtgcagc tgcaggagtc gggcccagga ctggtgcagc cttcacagac cctgaccctc       60

acctgcactg tctctggtga ctccatcagc aacgaggatt accactggac ctggatccgc      120

cagcacccgg gtaagggcct ggagtggatg gggtacctcc agtacagtgg gaacaccaac      180

tacaatccgt ccctcaagag tcgaatgacg atctcagtcg acacgtcaaa gaaccagttc      240

tccctgaggt tgaactctgt gactgccgcg gacacggccg tgtatttctg tgcgaccagt      300

atagtactga ctgggatgtc gaacaagatc cagccctttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcgg                                                   379


<210>  84
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8 VL

<400>  84
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagat ggccaggatc       60

acctgctctg gagaagcatt gccaaaaaaa tatgcatatt ggtatcagca gaagggaggc      120

cagttccctg tgttggtgat atataaagac accgagaggc cctcggggat ccctgagcga      180

ttctctggct ccagctcagg gacaatagtc acattgacca tcagtggagt ccagccagaa      240

gacgaggctg actattattg tctatcagca gacaccagtg gtacttgggt gttcggcgga      300

gggaccaagc tgaccgtcct ag                                               322


<210>  85
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_A7 CDRH3

<400>  85
gcgaccagca ttgttctgac tgggatgtcg aacaagatcc agccctttga ctac             54


<210>  86
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_A7 CDRL2 long

<400>  86
gtgatttata aagacaccga gaggccc                                           27


<210>  87
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_A7 VH

<400>  87
caggtgcagc tgcaggagtc gggcccagga ctggtgcagc cttcacagac cctgaccctc       60

acctgcactg tctctggtga ctccatcagc aacgaggatt accactggac ctggatccgc      120

cagcccccgg gtaagggcct ggagtggatg gggtacctcc agtacagtgg gaacaccaac      180

tacaatccgt ccctcaagag ccgaatgacg atctcagtcg acacgtcaaa gaaccagttc      240

tccctgaggt tgagctctgt gactgccgcg gacacggctg tgtatttctg tgcgaccagc      300

attgttctga ctgggatgtc gaacaagatc cagccctttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcgg                                                   379


<210>  88
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_A7 VL

<400>  88
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagat ggccaggatc       60

acctgctctg gagaagcatt gccaaaaaaa tatgcttatt ggtaccaaca gaaggcaggc      120

cagttccctg tgttggtgat ttataaagac accgagaggc cctcggggat ccctgagcga      180

ttctctggct ccagctcagg gacaatagtc acattgacca tcagtggagt ccagccagaa      240

gacgaggctg actattactg tctatcagca gacaccagtg gtacttgggt gttcggcgga      300

gggaccaagc tgaccgtcct ag                                               322


<210>  89
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRH1

<400>  89
ggattcacct ctaaaaacac tgct                                              24


<210>  90
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRH2

<400>  90
atcgacatca gtaattatat caca                                              24


<210>  91
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRH3

<400>  91
gcggcagtcg ggaaagatga tgatgttctg actggtggga ataagtactt cgatcac          57


<210>  92
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRL1

<400>  92
gcattgccaa aaaagtat                                                     18


<210>  93

<400>  93
000

<210>  94
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRL2 long

<400>  94
gtcatccatg aagacgacaa gcgaccc                                           27


<210>  95
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 CDRL3

<400>  95
tactcgacag acaccaatga taatcatgcc                                        30


<210>  96
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 VH

<400>  96
gaggtgcagc tggtgcagtc tgggcctgag gtgaagaagc cggggacttc agcgagggtc       60

tcctgcaagg cttctggatt cacctctaaa aacactgctt tgcagtgggt tcgacaggcc      120

cgcggacagc cccttgagtg gatgggatgg atcgacatca gtaattatat cacaaactac      180

gcacagaagt tccgaggaag acttaccatt acctgggacc tgtccgcaag tatggcctat      240

atggagttga gcagtctgag atccgaggac acggccgtct attattgtgc ggcagtcggg      300

aaagatgatg atgttctgac tggtgggaat aagtacttcg atcactgggg ccagggaacc      360

ctggtcaccg tctcctcgg                                                   379


<210>  97
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_C9 VL

<400>  97
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacaaac ggccaggatc       60

acctgctctg gagatgcatt gccaaaaaag tatgcttatt ggtatcagca gaaatcaggc      120

caggcccctg tgttggtcat ccatgaagac gacaagcgac cctccgggat ccctgggaga      180

ttctctgcct ccagctcagg gacaacggcc accttgacta tcagtggggc ccaggtggaa      240

gatgaagctg attactattg ctactcgaca gacaccaatg ataatcatgc cttcggatct      300

gggaccaaac tcaccgttct ga                                               322


<210>  98
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRH1

<400>  98
ggtggctcca tcagcagtgg tggttactac                                        30


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRH2

<400>  99
atctattaca gtgggagcac c                                                 21


<210>  100
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRH3

<400>  100
gcgaccagta tagttctgag tgggatgtcg aacaagatcc agccctttga ctac             54


<210>  101

<400>  101
000

<210>  102
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRL2 long

<400>  102
gtgatatata aagacagcga gaggccc                                           27


<210>  103
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA CDRL3

<400>  103
ctatcagcag acagcagtgg tacttgggtg                                        30


<210>  104
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA VH

<400>  104
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgaccagt      300

atagttctga gtgggatgtc gaacaagatc cagccctttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcag                                                   379


<210>  105
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_B8_UCA VL

<400>  105
tcctatgagc tgacacagcc accctcggtg tcagtgtccc taggacagat ggccaggatc       60

acctgctctg gagaagcatt gccaaaaaaa tatgcttatt ggtaccagca gaagccaggc      120

cagttccctg tgctggtgat atataaagac agcgagaggc cctcagggat ccctgagcga      180

ttctctggct ccagctcagg gacaatagtc acattgacca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tctatcagca gacagcagtg gtacttgggt gttcggcgga      300

gggaccaagc tgaccgtc                                                    318


<210>  106
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRH1

<400>  106
ggattcaact tcagtagtca tggc                                              24


<210>  107
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRH2

<400>  107
atctcttttc atggaaccca tcca                                              24


<210>  108
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRH3

<400>  108
gcgaaagacg tggtattacg atattttgac gcgatggacg tc                          42


<210>  109
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRL1

<400>  109
agcactggtg ttgggagtca taacctt                                           27


<210>  110

<400>  110
000

<210>  111
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRL2 long

<400>  111
atcatttatg aggtcactaa gcggccc                                           27


<210>  112
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 CDRL3

<400>  112
tgttcatatg caggtaccgg caattcttgg gtg                                    33


<210>  113
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 VH

<400>  113
gaggtgcagc tggtggagtc tgggggaggc gttgtccagc ctgggaggtc cctgagactc       60

acatgtgtag cctctggatt caacttcagt agtcatggca tgcactgggt ccgacaggct      120

ccaggcaagg gactggagtg ggtggcagca atctcttttc atggaaccca tccatattat      180

gtagactccg taaagggccg attcacaatt tcaagagaca attccaagaa cacactgtat      240

ctgcagatgg acagcctggg acctgacgac acggctattt attactgtgc gaaagacgtg      300

gtattacgat attttgacgc gatggacgtc tggggccaag ggaccacggt caccatctcc      360

tca                                                                    363


<210>  114
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_G12 VL

<400>  114
caggctgccc tgactcagcc tgcctccgtg tctggctctc ctggccagtc gatcaccatc       60

tcctgcactg gagccagcac tggtgttggg agtcataacc ttgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatcatt tatgaggtca ctaagcggcc ctcaggggtt      180

tctactcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctggcctc      240

caggctgacg acgaggctga ttatcactgc tgttcatatg caggtaccgg caattcttgg      300

gtgttcggcg gagggaccaa gctgaccgtc ctaa                                  334


<210>  115
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRH1

<400>  115
ggattcacct tcagtagtta tggc                                              24


<210>  116
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRH2

<400>  116
atctcatatc atggaaccca tcca                                              24


<210>  117
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRH3

<400>  117
gcgaaagacc tggtattacg atattttgac tcgatggacg tc                          42


<210>  118
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRL1

<400>  118
agcagtggtg ttgggagtca tgacctt                                           27


<210>  119
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRL2 long

<400>  119
atgatttatg aggtcactag gcggccc                                           27


<210>  120
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 CDRL3

<400>  120
tgctcatatg caggtactgg caattcttgg gtt                                    33


<210>  121
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 VH

<400>  121
gaggtgcagc tggtgcagtc tggtggaggc gttgtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcagca atctcatatc atggaaccca tccatattat      180

gtagactccg taaagggccg attcacaatt tcaagagaca attccaagaa cacactgtat      240

ctgcagatgg gcagcctggg acctgacgac acggctgtgt attactgtgc gaaagacctg      300

gtattacgat attttgactc gatggacgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  122
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_D10 VL

<400>  122
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tggtgttggg agtcatgacc ttgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgaggtca ctaggcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttatcactgc tgctcatatg caggtactgg caattcttgg      300

gttttcggcg gagggacgaa gctgaccgtc ctag                                  334


<210>  123
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 CDRH1

<400>  123
ggattcagct ttagtagtta tggc                                              24


<210>  124
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 CDRH2

<400>  124
atctcatttc atggaaccca tccg                                              24


<210>  125
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 CDRL1

<400>  125
agcagtggtg ttgggagtca taacctt                                           27


<210>  126
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 CDRL2 long

<400>  126
ataatttatg aggtcactaa gcggccc                                           27


<210>  127
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 CDRL3

<400>  127
tgctcatatg caggtactgg caattcttgg gtg                                    33


<210>  128
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 VH

<400>  128
gaggtgcagc tggtggagtc tggtggaggc gttgtccagc ctgggaggtc cctgagactc       60

tcctgtgtgg cctctggatt cagctttagt agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcagcg atctcatttc atggaaccca tccgttttat      180

ggagactccg taaagggccg attcacaatc tctagagaca attccaagag cacattgttt      240

ctggacatgg gcagcctggg aactgacgat acggctgttt attactgtgc gaaagacgtg      300

gtattacgat attttgacgc gatggacgtc tggggccaag ggagcacggt caccgtctcc      360

tca                                                                    363


<210>  129
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM99_E3 VL

<400>  129
caggcagggc agactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gagccagcag tggtgttggg agtcataacc ttgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcataatt tatgaggtca ctaagcggcc ctcaggggtt      180

tctgatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttatcactgc tgctcatatg caggtactgg caattcttgg      300

gtgttcggcg gagggaccaa gctgaccgtc ctag                                  334


<210>  130
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRH1

<400>  130
ggattcacct tcagtaggta ctgg                                              24


<210>  131
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRH2

<400>  131
acaagcggtg atgggagtat caca                                              24


<210>  132
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRH3

<400>  132
gcaagggccc tatattacta tgatagtagt gattatgggg tcaactggtt cgacccc          57


<210>  133
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRL1

<400>  133
agctccaaca tcggggcagg ttatgat                                           27


<210>  134

<400>  134
000

<210>  135
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRL2 Long

<400>  135
ctcatctatg ctagcaccaa tcggccc                                           27


<210>  136
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 CDRL3

<400>  136
cagtcctatg acatcagcct ggaggtc                                           27


<210>  137
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 VH

<400>  137
gaggttcagc tggtggagtc tgggggaggc ttaattcagc ctggggggtc cctgagactc       60

tcctgtgtag cctctggatt caccttcagt aggtactggg tgcactgggt ccgccaagct      120

ccaggtaagg ggctggtgtg ggtctcacgt acaagcggtg atgggagtat cacaatctac      180

gcggactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacactgttt      240

ctgcaaatga acagtctgag agtcgaggac acggctgttt attactgtgc aagggcccta      300

tattactatg atagtagtga ttatggggtc aactggttcg acccctgggg ccagggaacc      360

ctggtcaccg tctcctcag                                                   379


<210>  138
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM13_G9 VL

<400>  138
caggctgtgc tgactcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatgctagca ccaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

cgggctgagg atgaggctga ctattactgc cagtcctatg acatcagcct ggaggtcttc      300

ggaactggga ccaaggtcac cgtcctag                                         328


<210>  139
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRH1

<400>  139
ggattcacct tcaataacta tgcc                                              24


<210>  140
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRH2

<400>  140
atatcgtatg agggaagtct caaa                                              24


<210>  141
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRH3

<400>  141
gcgaggagcc acggcttatt tgaactccca ccgttctacc ttgattac                    48


<210>  142
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRL1

<400>  142
agcagtgacg ttggtggcta taactat                                           27


<210>  143
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRL2 long

<400>  143
atgatttatg aggtcactaa tcggccc                                           27


<210>  144
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 CDRL3

<400>  144
agctctttta caagccgaag cactcatgtc                                        30


<210>  145
<211>  367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 VH

<400>  145
gaagtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcaat aactatgcca tgcactgggt ccgccaggcc      120

ccaggcaagg ggctggagtg gttggcacga atatcgtatg agggaagtct caaatcctat      180

gcagagtccg tggagggccg attcaccatt tccagagaca gttccaacac gctttatttg      240

caaatgcaca gcctgacagt tgaggacacg gctgtgtatt actgtgcgag gagccacggc      300

ttatttgaac tcccaccgtt ctaccttgat tactggggcc agggaaccct ggtcaccgtt      360

tattcag                                                                367


<210>  146
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLM20_Bis_B3 VL

<400>  146
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatg       60

tcctgcactg ggaccagcag tgacgttggt ggctataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgaggtca ctaatcggcc ctcaggtgtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattattgc agctctttta caagccgaag cactcatgtc      300

ttcggaagtg ggaccaaggt caccgtccta g                                     331


