                         б

<110>  ҽҩݣ޹˾ҽҩϺ޹˾

<120>  ԭϵ׼;

<130>  0229-PA-004

<160>  236

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A+1 HCDR1

<400>  1

Gly Ser Asp Pro Ser Ile Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A HCDR2

<400>  2

Ile Gly Trp Ser Ala Ala Thr Thr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A+2-17+20-21+23+27-29+32-33+35-36+39+41-42+44-45+47 HCDR3

<400>  3

Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr 
1               5                   10      


<210>  4
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-2 HCDR1

<400>  4

Gly Arg Phe Pro Ser Ile Tyr Ala 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-3 HCDR1

<400>  5

Gly Ser Gly Arg Ser Ile Tyr Ala 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-4 HCDR1

<400>  6

Gly Ser Val Gly Ser Ile Tyr Ala 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-5 HCDR1

<400>  7

Gly Ser Ser Leu Ser Ile Tyr Ala 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-6 HCDR1

<400>  8

Gly Arg Arg Pro Ser Ile Tyr Ala 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-7+21-22+31+39-40+43+48-49 HCDR1

<400>  9

Gly Ser Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-8 HCDR1

<400>  10

Gly Gly Arg Pro Ser Ile Tyr Ala 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-9 HCDR1

<400>  11

Gly Ser Gly His Ser Ile Tyr Ala 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-10 HCDR1

<400>  12

Gly Ser Asp Asp Arg Ile Tyr Ala 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-11 HCDR1

<400>  13

Gly Ser Gln Leu Ser Ile Tyr Ala 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-12 HCDR1

<400>  14

Gly Ser Asp Tyr Ala Ile Tyr Ala 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-13 HCDR1

<400>  15

His Ala Asp Pro Ser Ile Tyr Ala 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-14 HCDR1

<400>  16

Ser His Arg Pro Ser Ile Tyr Ala 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-15 HCDR1

<400>  17

Gly Leu Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-16 HCDR1

<400>  18

Gly Ser Arg Val Ser Ile Tyr Ala 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-17 HCDR1

<400>  19

Gly Ser Ile Ser Ser Ile Tyr Ala 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-18 HCDR1

<400>  20

Gly Ser Arg Ser Ser Ile Tyr Ala 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-19 HCDR1

<400>  21

Gly Ser Glu Val Ser Ile Tyr Ala 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-20 HCDR1

<400>  22

Gly Ser Arg Lys Ser Ile Tyr Ala 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-23 HCDR1

<400>  23

Gly Thr Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-24 HCDR1

<400>  24

Gly Ser Arg His Ser Ile Tyr Ala 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-25+30 HCDR1

<400>  25

Gly Val Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-26 HCDR1

<400>  26

Gly Ser Arg Ser Asn Ile Tyr Ala 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-27 HCDR1

<400>  27

Lys Ser Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-28 HCDR1

<400>  28

Lys Leu Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-29 HCDR1

<400>  29

Gly Ser Gly Gly Ser Ile Tyr Ala 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-32 HCDR1

<400>  30

Lys Asn Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-33 HCDR1

<400>  31

Gly Ser Arg Ser Gln Ile Tyr Ala 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-35 HCDR1

<400>  32

Ala Pro Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-36 HCDR1

<400>  33

Gly Ser Arg Arg Phe Ile Tyr Ala 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-37 HCDR1

<400>  34

Gly Ala Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-38 HCDR1

<400>  35

Gly Asn Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-41 HCDR1

<400>  36

Val Ser Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-42 HCDR1

<400>  37

Gly Ser Arg Gln Thr Ile Tyr Ala 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-44 HCDR1

<400>  38

Gly Ser Arg Thr Arg Ile Tyr Ala 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-45 HCDR1

<400>  39

His Leu Arg Arg Ser Ile Tyr Ala 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-46 HCDR1

<400>  40

Gly Ser Lys Gly Ser Ile Tyr Ala 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-47 HCDR1

<400>  41

Gly Ser Arg Leu Ser Ile Tyr Ala 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-1 HCDR2

<400>  42

Ile Gly Trp Ala Trp Ala Thr Thr 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-2+10+14 HCDR2

<400>  43

Ile Gly Trp Arg Tyr Ala Thr Thr 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-3+9 HCDR2

<400>  44

Ile Gly Trp Ser Tyr Ala Thr Thr 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-4+8+12 HCDR2

<400>  45

Ile Gly Trp Ala Phe Ala Thr Thr 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-5+7+16-17+19-20+22-27+29+32-33+37-38+40-41+43+45-49 HCDR2

<400>  46

Ile Gly Trp Ala Tyr Ala Thr Thr 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-6+13 HCDR2

<400>  47

Ile Gly Trp Asn Tyr Ala Thr Thr 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-11 HCDR2

<400>  48

Ile Gly Trp Arg Phe Ala Thr Thr 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-15 HCDR2

<400>  49

Ile Gly Trp Ala Tyr Ser Thr Thr 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-18+31 HCDR2

<400>  50

Leu Gly Trp Ala Tyr Ala Thr Thr 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-21 HCDR2

<400>  51

Ile Gly Trp Ala Tyr Ala Thr Ser 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-28+30+36+42 HCDR2

<400>  52

Ile Gly Trp Ala Tyr Ala Thr Gln 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-35 HCDR2

<400>  53

Ile Gly Trp Ala Tyr Gly Thr Thr 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-39+44 HCDR2

<400>  54

Ile Gly Trp Ala Tyr Ala Thr Glu 
1               5               


<210>  55
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-1+46 HCDR3

<400>  55

Ala Ala Asp Leu Asp Arg Ser Gly Phe Asp Tyr 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-18 HCDR3

<400>  56

Ala Ala Asp Leu Asp His Leu Gly Phe Asp Tyr 
1               5                   10      


<210>  57
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-19+38 HCDR3

<400>  57

Ala Ala Asp Leu Asp Arg Arg Gly Phe Asp Tyr 
1               5                   10      


<210>  58
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-22 HCDR3

<400>  58

Ala Ala Asp Leu Asp Arg Gly Gly Phe Asp Tyr 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-24+43 HCDR3

<400>  59

Ala Ala Asp Leu Asp Arg Ala Gly Phe Asp Tyr 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-25 HCDR3

<400>  60

Ala Ala Asp Leu Asp Arg His Gly Phe Asp Tyr 
1               5                   10      


<210>  61
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-26 HCDR3

<400>  61

Ala Ala Asp Leu Asp Arg Asp Gly Phe Asp Tyr 
1               5                   10      


<210>  62
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-30 HCDR3

<400>  62

Ala Ala Asp Ile Asp His Ser Gly Phe Asp Tyr 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-31 HCDR3

<400>  63

Ala Ala Asp Leu Asp His His Gly Phe Asp Tyr 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-37 HCDR3

<400>  64

Ala Ala Asp Leu Asp Arg Thr Gly Phe Asp Tyr 
1               5                   10      


<210>  65
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-40 HCDR3

<400>  65

Ala Ala Asp Leu Asp Val Ala Gly Phe Asp Tyr 
1               5                   10      


<210>  66
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-48 HCDR3

<400>  66

Ala Ala Asp Leu Asp Arg Asn Gly Phe Asp Tyr 
1               5                   10      


<210>  67
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-49 HCDR3

<400>  67

Ala Ala Asp Leu Asp Arg Val Gly Phe Asp Tyr 
1               5                   10      


<210>  68
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1+MHPD1-A-H3+5-8 H-FR1

<400>  68

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  69
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2+MHPD1-A-H1-3+5+9-10+12+14-16 H-FR2

<400>  69

Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val Ala 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3+MHPD1-A-H1+6+8 H-FR3

<400>  70

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Val Ala Leu Leu Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  71
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4+MHPD1-A-H2-3+5-8 H-FR4

<400>  71

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  72
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A

<400>  72

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  73
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-1

<400>  73

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Trp Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  74
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-2

<400>  74

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Phe Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Arg Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  75
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-3

<400>  75

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Gly Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  76
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-4

<400>  76

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Val Gly Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Phe Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  77
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-5

<400>  77

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Ser Leu Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  78
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-6

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Arg Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Asn Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  79
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-7

<400>  79

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  80
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-8

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Gly Arg Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Phe Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  81
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-9

<400>  81

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Gly His Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  82
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-10

<400>  82

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Asp Arg Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Arg Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  83
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-11

<400>  83

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Gln Leu Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Arg Phe Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  84
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-12

<400>  84

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Tyr Ala Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Phe Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  85
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-13

<400>  85

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser His Ala Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Asn Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  86
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-14

<400>  86

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Ser His Arg Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Arg Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  87
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-15

<400>  87

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Leu Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ser Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  88
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-16

<400>  88

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Val Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  89
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-17

<400>  89

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  90
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-18

<400>  90

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Ser Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Leu Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Leu Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  91
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-19

<400>  91

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Glu Val Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  92
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-20

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Lys Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  93
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-21

<400>  93

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  94
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-22

<400>  94

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  95
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-23

<400>  95

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  96
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-24

<400>  96

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg His Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Ala Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  97
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-25

<400>  97

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Val Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg His Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  98
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-26

<400>  98

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Ser Asn Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  99
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-27

<400>  99

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Lys Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  100
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-28

<400>  100

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Lys Leu Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  101
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-29

<400>  101

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Gly Gly Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  102
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-30

<400>  102

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Val Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ile Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  103
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-31

<400>  103

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Leu Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His His Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  104
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-32

<400>  104

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Lys Asn Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  105
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-33

<400>  105

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Ser Gln Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  106
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-35

<400>  106

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Ala Pro Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  107
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-36

<400>  107

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Phe Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  108
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-37

<400>  108

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ala Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  109
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-38

<400>  109

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Asn Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  110
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-39

<400>  110

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  111
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-40

<400>  111

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Val Ala Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  112
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-41

<400>  112

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Val Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  113
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-42

<400>  113

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Gln Thr Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  114
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-43

<400>  114

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Ala Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  115
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-44

<400>  115

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Thr Arg Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  116
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-45

<400>  116

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser His Leu Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  117
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-46

<400>  117

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Lys Gly Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  118
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-47

<400>  118

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Leu Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  119
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-48

<400>  119

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Asn Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  120
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-49

<400>  120

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Val Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  121
<211>  232
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Fc(hIgG1 Fc D239E,L241M)

<400>  121

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  122
<211>  350
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A Fc

<400>  122

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 


<210>  123
<211>  232
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Fc(hIgG1 Fc)

<400>  123

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  124
<211>  232
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Fc(hIgG1 Fc N297Q)

<400>  124

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  125
<211>  229
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Fc(hIgG4 Fc S228P)

<400>  125

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  126
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda HCDR1

<400>  126

Asn Tyr Tyr Met Tyr 
1               5   


<210>  127
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda HCDR2

<400>  127

Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  128
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda HCDR3

<400>  128

Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
1               5                   10      


<210>  129
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda LCDR1

<400>  129

Arg Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
1               5                   10                  15  


<210>  130
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda LCDR2

<400>  130

Leu Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  131
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda LCDR3

<400>  131

Gln His Ser Arg Asp Leu Pro Leu Thr 
1               5                   


<210>  132
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda VH

<400>  132

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  133
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda VL

<400>  133

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  134
<211>  447
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda 

<400>  134

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  135
<211>  218
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Keytruda 

<400>  135

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  136
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1ͨʽ1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AlaGlyHisLysSerVal

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = AlaGlyHisLeuAsnProArgSerThrVal

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AspGluPheGlyIleLysGlnArgSerVal

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AspGlyHisLysLeuProGlnArgSerThrValTyr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AlaPheAsnGlnArgSerThr

<400>  136

Xaa Xaa Xaa Xaa Xaa Ile Tyr Ala 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2ͨʽ1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AlaAsnArgSer

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AlaPheTrpTyr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AlaGlySer

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = GluGlnSerThr

<400>  137

Xaa Gly Trp Xaa Xaa Xaa Thr Xaa 
1               5               


<210>  138
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3ͨʽ1

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = HisArgVal

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = AlaAspGlyHisLeuAsnArgSerThrVal

<400>  138

Ala Ala Asp Xaa Asp Xaa Xaa Gly Phe Asp Tyr 
1               5                   10      


<210>  139
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHHͨʽ1

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = AlaGlyHisLysSerVal

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = AlaGlyHisLeuAsnProArgSerThrVal

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = AspGluPheGlyIleLysGlnArgSerVal

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = AspGlyHisLysLeuProGlnArgSerThrValTyr

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = AlaPheAsnGlnArgSerThr

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = AlaAsnArgSer

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = AlaPheTrpTyr

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = AlaGlySer

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = GluGlnSerThr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa = HisArgVal

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = AlaAspGlyHisLeuAsnArgSerThrVal

<400>  139

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Xaa Gly Trp Xaa Xaa Xaa Thr Xaa Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Xaa Asp Xaa Xaa Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  140
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1ͨʽ2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GlyHisLys

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = AlaGlyLeuAsnSerVal

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AspArgVal

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = GlyHisProGlnArgThr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = ArgSerThr

<400>  140

Xaa Xaa Xaa Xaa Xaa Ile Tyr Ala 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2ͨʽ2

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AlaAsn

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = GluGlnThr

<400>  141

Ile Gly Trp Xaa Xaa Xaa Thr Xaa 
1               5               


<210>  142
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3ͨʽ2

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = HisArg

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = AlaHisSer

<400>  142

Ala Ala Asp Xaa Asp Xaa Xaa Gly Phe Asp Tyr 
1               5                   10      


<210>  143
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHHͨʽ2

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = GlyHisLys

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = AlaGlyLeuAsnSerVal

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = AspArgVal

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = GlyHisProGlnArgThr

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = ArgSerThr

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = AlaAsn

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = GluGlnThr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa = HisArg

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = AlaHisSer

<400>  143

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Xaa Xaa Xaa Thr Xaa Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Xaa Asp Xaa Xaa Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  144
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H1 H-FR1

<400>  144

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  145
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H2 H-FR1

<400>  145

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  146
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H9-10+12+14-15+17 H-FR1

<400>  146

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  147
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-1-6+8-14+H16+18-19 H-FR1

<400>  147

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  148
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-7+15-49 H-FR1

<400>  148

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser 
            20                  25  


<210>  149
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H6-7 H-FR2

<400>  149

Met Met Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val Ala 
1               5                   10                  15      


Gly 
    


<210>  150
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-1-49 H8+17-19 H-FR2

<400>  150

Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ala 
1               5                   10                  15      


Gly 
    


<210>  151
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-34 H-FR2

<400>  151

Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ala 
1               5                   10                  15      


Gly 
    


<210>  152
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H2+9 H-FR3

<400>  152

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Val Ala Leu Leu Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  153
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H3 H-FR3

<400>  153

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Leu Ala Leu Leu Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  154
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H5 H-FR3

<400>  154

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  155
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H7 H-FR3

<400>  155

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Val Ala Leu Leu Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  156
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H10 H-FR3

<400>  156

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Leu Ala Leu Leu Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  157
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H12 H-FR3

<400>  157

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Leu Ala Leu Leu Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  158
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H14 H-FR3

<400>  158

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  159
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H15+17-18 H-FR3

<400>  159

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  160
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H16 H-FR3

<400>  160

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Val Ala Leu Leu Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  161
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-1-49+H19 H-FR3

<400>  161

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Thr Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  162
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-1-49+H1+9-10+12+14-19 H-FR4

<400>  162

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  163
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H1

<400>  163

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  164
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H2

<400>  164

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  165
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H3

<400>  165

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  166
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H5

<400>  166

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  167
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H6

<400>  167

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Met Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  168
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H7

<400>  168

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Met Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  169
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H8

<400>  169

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  170
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H9

<400>  170

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  171
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H10

<400>  171

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  172
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H12

<400>  172

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  173
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H14

<400>  173

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  174
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H15

<400>  174

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  175
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H16

<400>  175

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gly Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ala 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  176
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H17

<400>  176

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  177
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H18

<400>  177

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  178
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-H19

<400>  178

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Ala Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  179
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-1 H

<400>  179

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Trp Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  180
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-2 H

<400>  180

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Phe Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Arg Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  181
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-3 H

<400>  181

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  182
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-4 H

<400>  182

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Gly Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Phe Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  183
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-5 H

<400>  183

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Leu Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  184
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-6 H

<400>  184

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Arg Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Asn Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  185
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-7 H

<400>  185

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  186
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-8 H

<400>  186

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Arg Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Phe Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  187
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-9 H

<400>  187

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly His Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ser Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  188
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-10 H

<400>  188

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Asp Arg Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Arg Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  189
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-11 H

<400>  189

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gln Leu Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Arg Phe Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  190
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-12 H

<400>  190

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Asp Tyr Ala Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Phe Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  191
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-13 H

<400>  191

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser His Ala Asp Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Asn Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  192
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-14 H

<400>  192

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser His Arg Pro Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Arg Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  193
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-15 H

<400>  193

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Leu Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ser Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  194
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-16 H

<400>  194

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Val Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  195
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-17 H

<400>  195

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Ile Ser Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  196
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-18 H

<400>  196

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Ser Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Leu Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Leu Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  197
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-19 H

<400>  197

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Glu Val Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  198
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-20 H

<400>  198

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Lys Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  199
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-21 H

<400>  199

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  200
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-22 H

<400>  200

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  201
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-23 H

<400>  201

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Thr Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  202
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-24 H

<400>  202

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg His Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Ala Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  203
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-25 H

<400>  203

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Val Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg His Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  204
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-26 H

<400>  204

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Ser Asn Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  205
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-27 H

<400>  205

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Lys Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  206
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-28 H

<400>  206

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Lys Leu Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  207
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-29 H

<400>  207

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Gly Gly Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  208
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-30 H

<400>  208

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Val Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ile Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  209
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-31 H

<400>  209

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Leu Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His His Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  210
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-32 H

<400>  210

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Lys Asn Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  211
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-33 H

<400>  211

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Ser Gln Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  212
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-34 H

<400>  212

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  213
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-35 H

<400>  213

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Pro Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  214
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-36 H

<400>  214

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Phe Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  215
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-37 H

<400>  215

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ala Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  216
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-38 H

<400>  216

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Asn Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  217
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-39 H

<400>  217

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  218
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-40 H

<400>  218

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Val Ala Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  219
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-41 H

<400>  219

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Val Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  220
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-42 H

<400>  220

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Gln Thr Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  221
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-43 H

<400>  221

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Ala Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  222
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-44 H

<400>  222

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Thr Arg Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  223
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-45 H

<400>  223

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser His Leu Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  224
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-46 H

<400>  224

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Lys Gly Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  225
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-47 H

<400>  225

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Leu Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp His Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  226
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-48 H

<400>  226

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Asn Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  227
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  MHPD1-A-49 H

<400>  227

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Arg Ser Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Ala Tyr Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Arg Val Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  228
<211>  232
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Fc(hIgG1 Fc C220A L234A L235A)

<400>  228

Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  229
<211>  232
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Fc(hIgG1 Fc C220S L234A L235A)

<400>  229

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  230
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽ1

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuSer

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = ProVal

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = AlaThr

<400>  230

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Xaa Ser 
            20                  25  


<210>  231
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2ͨʽ1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AlaMet

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = GlyMet

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = HisLeu

<400>  231

Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Phe Val Ala 
1               5                   10                  15      


Gly 
    


<210>  232
<211>  38
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3ͨʽ1

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = GlyThr

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = AlaTyr

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = LeuGln

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = IleVal

<400>  232

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Xaa Ile Ser Arg Asp Asn 
1               5                   10                  15      


Xaa Lys Asn Thr Xaa Xaa Leu Xaa Met Asn Ser Leu Xaa Xaa Glu Asp 
            20                  25                  30          


Thr Ala Xaa Tyr Tyr Cys 
        35              


<210>  233
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4ͨʽ1

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuGln

<400>  233

Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  234
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHH Hͨʽ1

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuSer

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = ProVal

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = AlaGlyHisLysSerVal

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = AlaGlyHisLeuAsnProArgSerThrVal

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = AspGluPheGlyIleLysGlnArgSerVal

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = AspGlyHisLysLeuProGlnArgSerThrValTyr

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = AlaPheAsnGlnArgSerThr

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = AlaMet

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = GlyMet

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = HisLeu

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = AlaAsnArgSer

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = AlaPheTrpTyr

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = AlaGlySer

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = GluGlnSerThr

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa = GlyThr

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = AlaTyr

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = LeuGln

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa = HisArgVal

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = AlaAspGlyHisLeuAsnArgSerThrVal

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa = LeuGln

<400>  234

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Xaa Ser Xaa Xaa Xaa Xaa Xaa Ile Tyr 
            20                  25                  30          


Ala Xaa Xaa Trp Phe Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Phe Val 
        35                  40                  45              


Ala Gly Xaa Gly Trp Xaa Xaa Xaa Thr Xaa Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Xaa Ile Ser Arg Asp Asn Xaa Lys Asn Thr Xaa Xaa 
65                  70                  75                  80  


Leu Xaa Met Asn Ser Leu Xaa Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Xaa Asp Xaa Xaa Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Xaa Val Thr Val Ser Ser 
        115             


<210>  235
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽ2

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = AlaThr

<400>  235

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Xaa Ser 
            20                  25  


<210>  236
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHH Hͨʽ2

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = GlyHisLys

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = AlaGlyLeuAsnSerVal

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = AspArgVal

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = GlyHisProGlnArgThr

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = ArgSerThr

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = AlaAsn

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = GluGlnThr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa = HisArg

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = AlaHisSer

<400>  236

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Xaa Ser Xaa Xaa Xaa Xaa Xaa Ile Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Trp Xaa Xaa Xaa Thr Xaa Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Xaa Asp Xaa Xaa Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             
