                         б
<110>  Ŵҩݣ޹˾ 
<120>  CD16Aĵ弰;
<130>  
<150>  CN202110112841.1  
<151>  2021-01-27
<160>  34    
<170>  PatentIn汾3.3
<210>  1
<211>  118
<212>  PRT
<213>  ˹
<220>  
<223>  Y88A3 sdAb
<400>  1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asn Phe Thr Arg Val 
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Gly Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Leu Asp Asp Tyr Ser Gly Val Leu Ser Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             
<210>  2
<211>  120
<212>  PRT
<213>  ˹
<220>  
<223>  Y95H1 sdAb
<400>  2
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Met Tyr 
            20                  25                  30          
Val Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile His Glu Asp Gly Gly Lys Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ala Tyr Asp Tyr Ser Tyr Ser Glu Trp Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 
<210>  3
<211>  117
<212>  PRT
<213>  ˹
<220>  
<223>  Y99F6 sdAb
<400>  3
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Asn Ser Phe 
            20                  25                  30          
Val Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile His Glu Asp Gly Gly Lys Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Val Thr His Ser Leu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         
<210>  4
<211>  118
<212>  PRT
<213>  ˹
<220>  
<223>  Y100D6 sdAb
<400>  4
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Trp Tyr 
            20                  25                  30          
Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile His Asp Asp Gly Thr Glu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Val Arg Ser Asp Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             
<210>  5
<211>  227
<212>  PRT
<213>  ˹
<220>  
<223>  IgG1-Fc-LALA
<400>  5
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly Lys 
225         
<210>  6
<211>  120
<212>  PRT
<213>  ˹
<220>  
<223>  4LS21 VH
<400>  6
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Glu Pro Met Tyr Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 
<210>  7
<211>  106
<212>  PRT
<213>  ˹
<220>  
<223>  4LS21 VL
<400>  7
Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      
Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          
His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     
<210>  8
<211>  237
<212>  PRT
<213>  ˹
<220>  
<223>  CD16A-158V-G129D
<400>  8
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      
Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln 
            20                  25                  30          
Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly 
        35                  40                  45              
Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser 
    50                  55                  60                  
Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val 
65                  70                  75                  80  
Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser 
                85                  90                  95      
Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala 
            100                 105                 110         
Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His 
        115                 120                 125             
Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly 
    130                 135                 140                 
Lys Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys 
145                 150                 155                 160 
Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly 
                165                 170                 175     
Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly 
            180                 185                 190         
Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Gly 
        195                 200                 205             
Gly Gly Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
    210                 215                 220                 
Trp His Glu Gly Ser Gly Ser His His His His His His 
225                 230                 235         
<210>  9
<211>  237
<212>  PRT
<213>  ˹
<220>  
<223>  CD16A-158V-Y140A
<400>  9
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      
Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln 
            20                  25                  30          
Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly 
        35                  40                  45              
Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser 
    50                  55                  60                  
Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val 
65                  70                  75                  80  
Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser 
                85                  90                  95      
Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala 
            100                 105                 110         
Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His 
        115                 120                 125             
Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly 
    130                 135                 140                 
Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Ala Ile Pro Lys 
145                 150                 155                 160 
Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly 
                165                 170                 175     
Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly 
            180                 185                 190         
Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Gly 
        195                 200                 205             
Gly Gly Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
    210                 215                 220                 
Trp His Glu Gly Ser Gly Ser His His His His His His 
225                 230                 235         
<210>  10
<211>  6173
<212>  DNA
<213>  ˹
<220>  
<223>  pcDNA3.1ĺ
<400>  10
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg     60
ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg    120
cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc    180
ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt    240
gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata    300
tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc    360
cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc    420
attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt    480
atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt    540
atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca    600
tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg    660
actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc    720
aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg    780
gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca    840
ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc    900
gtttaaactt aagcttggta ccgagctcgg atccactagt ccagtgtggt ggaattctgc    960
agtcgacggt accgcgggcc cgggatccac cggtcgccac catggtgagc aagggcgagg   1020
agctgttcac cggggtggtg cccatcctgg tcgagctgga cggcgacgta aacggccaca   1080
agttcagcgt gtccggcgag ggcgagggcg atgccaccta cggcaagctg accctgaagt   1140
tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc accctgacct   1200
acggcgtgca gtgcttcagc cgctaccccg accacatgaa gcagcacgac ttcttcaagt   1260
ccgccatgcc cgaaggctac gtccaggagc gcaccatctt cttcaaggac gacggcaact   1320
acaagacccg cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc atcgagctga   1380
agggcatcga cttcaaggag gacggcaaca tcctggggca caagctggag tacaactaca   1440
acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag gtgaacttca   1500
agatccgcca caacatcgag gacggcagcg tgcagctcgc cgaccactac cagcagaaca   1560
cccccatcgg cgacggcccc gtgctgctgc ccgacaacca ctacctgagc acccagtccg   1620
ccctgagcaa agaccccaac gagaagcgcg atcacatggt cctgctggag ttcgtgaccg   1680
ccgccgggat cactctcggc atggacgagc tgtacaagta aagcggccgc tcgagtctag   1740
agggcccgtt taaacccgct gatcagcctc gactgtgcct tctagttgcc agccatctgt   1800
tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc   1860
ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg   1920
tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga   1980
tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcta gggggtatcc   2040
ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac   2100
cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc   2160
cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt   2220
tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg   2280
gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag   2340
tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt   2400
ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt   2460
taacgcgaat taattctgtg gaatgtgtgt cagttagggt gtggaaagtc cccaggctcc   2520
ccagcaggca gaagtatgca aagcatgcat ctcaattagt cagcaaccag gtgtggaaag   2580
tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc   2640
atagtcccgc ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct   2700
ccgccccatg gctgactaat tttttttatt tatgcagagg ccgaggccgc ctctgcctct   2760
gagctattcc agaagtagtg aggaggcttt tttggaggcc taggcttttg caaaaagctc   2820
ccgggagctt gtatatccat tttcggatct gatcaagaga caggatgagg atcgtttcgc   2880
atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc   2940
ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca   3000
gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg   3060
caggacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg   3120
ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag   3180
gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg   3240
cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc   3300
atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa   3360
gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac   3420
ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat   3480
ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac   3540
atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc   3600
ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt   3660
gacgagttct tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc   3720
tgccatcacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg   3780
ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg   3840
cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa   3900
atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca   3960
atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt   4020
catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg   4080
gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt   4140
tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg   4200
gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg   4260
actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa   4320
tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc   4380
aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc   4440
ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat   4500
aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc   4560
cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct   4620
cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg   4680
aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc   4740
cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga   4800
ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa   4860
gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta   4920
gctcttgatc cggcaaacaa accaccgctg gtagcggttt ttttgtttgc aagcagcaga   4980
ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg   5040
ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct   5100
tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt   5160
aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc   5220
tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg   5280
gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag   5340
atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt   5400
tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag   5460
ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt   5520
ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca   5580
tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg   5640
ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat   5700
ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta   5760
tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca   5820
gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct   5880
taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat   5940
cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa   6000
agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt   6060
gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa   6120
ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac gtc          6173
<210>  11
<211>  6934
<212>  DNA
<213>  ˹
<220>  
<223>  pXC17.4ĺ
<400>  11
gaattcattg atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa     60
cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt    120
gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa    180
agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca    240
tgtctggcgg ccgcgacctg caggcgcaga actggtaggt atggaagatc cctcgagatc    300
cattgtgctg gcggtaggcg agcagcgcct gcctgaagct gcgggcattc ccgatcagaa    360
atgagcgcca gtcgtcgtcg gctctcggca ccgaatgcgt atgattctcc gccagcatgg    420
cttcggccag tgcgtcgagc agcgcccgct tgttcctgaa gtgccagtaa agcgccggct    480
gctgaacccc caaccgttcc gccagtttgc gtgtcgtcag accgtctacg ccgacctcgt    540
tcaacaggtc cagggcggca cggatcactg tattcggctg caactttgtc atgcttgaca    600
ctttatcact gataaacata atatgtccac caacttatca gtgataaaga atccgcgcca    660
gcacaatgga tctcgaggtc gagggatctc tagaggatcc tctacgccgg acgcatcgtg    720
gccggcatca ccggcgccac aggtgcggtt gctggcgcct atatcgccga catcaccgat    780
ggggaagatc gggctcgcca cttcgggctc atgagcgctt gtttcggcgt gggtatggtg    840
gcaggccccg tggccggggg actgttgggc gccatctcct tgcatgcacc attccttgcg    900
gcggcggtgc tcaacggcct caacctacta ctgggctgct tcctaatgca ggagtcgcat    960
aagggagagc gtcgacctcg ggccgcgttg ctggcgtttt tccataggct ccgcccccct   1020
gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa   1080
agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg   1140
cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca   1200
cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa   1260
ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg   1320
gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg   1380
tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga   1440
acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc   1500
tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag   1560
attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac   1620
gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc   1680
ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag   1740
taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt   1800
ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag   1860
ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca   1920
gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact   1980
ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca   2040
gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg   2100
tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc   2160
atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg   2220
gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca   2280
tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt   2340
atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc   2400
agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc   2460
ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca   2520
tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa   2580
aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat   2640
tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa   2700
aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtctaagaa   2760
accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc ctgatggctc   2820
tttgcggcac ccatcgttcg taatgttccg tggcaccgag gacaaccctc aagagaaaat   2880
gtaatcacac tggctcacct tcgggtgggc ctttctgcgt ttataaggag acactttatg   2940
tttaagaagg ttggtaaatt ccttgcggct ttggcagcca agctagatcc ggctgtggaa   3000
tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag   3060
catgcatctc aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag   3120
aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc   3180
catcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt   3240
ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg   3300
aggctttttt ggaggcctag gcttttgcaa aaagctagct tggggccacc gctcagagca   3360
ccttccacca tggccacctc agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac   3420
ttgtgcctgc cccagggtga gaaagtccaa gccatgtata tctgggttga tggtactgga   3480
gaaggactgc gctgcaaaac ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta   3540
cctgagtgga attttgatgg ctctagtacc tttcagtctg agggctccaa cagtgacatg   3600
tatctcagcc ctgttgccat gtttcgggac cccttccgca gagatcccaa caagctggtg   3660
ttctgtgaag ttttcaagta caaccggaag cctgcagaga ccaatttaag gcactcgtgt   3720
aaacggataa tggacatggt gagcaaccag cacccctggt ttggaatgga acaggagtat   3780
actctgatgg gaacagatgg gcaccctttt ggttggcctt ccaatggctt tcctgggccc   3840
caaggtccgt attactgtgg tgtgggcgca gacaaagcct atggcaggga tatcgtggag   3900
gctcactacc gcgcctgctt gtatgctggg gtcaagatta caggaacaaa tgctgaggtc   3960
atgcctgccc agtgggagtt ccaaatagga ccctgtgaag gaatccgcat gggagatcat   4020
ctctgggtgg cccgtttcat cttgcatcga gtatgtgaag actttggggt aatagcaacc   4080
tttgacccca agcccattcc tgggaactgg aatggtgcag gctgccatac caactttagc   4140
accaaggcca tgcgggagga gaatggtctg aagcacatcg aggaggccat cgagaaacta   4200
agcaagcggc accggtacca cattcgagcc tacgatccca aggggggcct ggacaatgcc   4260
cgtcgtctga ctgggttcca cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc   4320
aatcgcagtg ccagcatccg cattccccgg actgtcggcc aggagaagaa aggttacttt   4380
gaagaccgcc gcccctctgc caattgtgac ccctttgcag tgacagaagc catcgtccgc   4440
acatgccttc tcaatgagac tggcgacgag cccttccaat acaaaaacta attagacttt   4500
gagtgatctt gagcctttcc tagttcatcc caccccgccc cagagagatc tttgtgaagg   4560
aaccttactt ctgtggtgtg acataattgg acaaactacc tacagagatt taaagctcta   4620
aggtaaatat aaaattttta agtgtataat gtgttaaact actgattcta attgtttgtg   4680
tattttagat tccaacctat ggaactgatg aatgggagca gtggtggaat gcctttaatg   4740
aggaaaacct gttttgctca gaagaaatgc catctagtga tgatgaggct actgctgact   4800
ctcaacattc tactcctcca aaaaagaaga gaaaggtaga agaccccaag gactttcctt   4860
cagaattgct aagttttttg agtcatgctg tgtttagtaa tagaactctt gcttgctttg   4920
ctatttacac cacaaaggaa aaagctgcac tgctatacaa gaaaattatg gaaaaatatt   4980
ctgtaacctt tataagtagg cataacagtt ataatcataa catactgttt tttcttactc   5040
cacacaggca tagagtgtct gctattaata actatgctca aaaattgtgt acctttagct   5100
ttttaatttg taaaggggtt aataaggaat atttgatgta tagtgccttg actagagatc   5160
ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc   5220
cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct   5280
tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca   5340
ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggatctct   5400
agcttcgtgt caaggacggt gaggcgcgcc tactgagtca ttagggactt tccaatgggt   5460
tttgcccagt acataaggtc aataggggtg aatcaacagg aaagtcccat tggagccaag   5520
tacactgagt caatagggac tttccattgg gttttgccca gtacaaaagg tcaatagggg   5580
gtgagtcaat gggtttttcc cattattggc acgtacataa ggtcaatagg ggtgagtcat   5640
tgggtttttc cagccaattt aattaaaacg ccatgtactt tcccaccatt gacgtcaatg   5700
ggctattgaa actaatgcaa cgtgaccttt aaacggtact ttcccatagc tgattaatgg   5760
gaaagtaccg ttctcgagcc aatacacgtc aatgggaagt gaaagggcag ccaaaacgta   5820
acaccgcccc ggttttcccc tggaaattcc atattggcac gcattctatt ggctgagctg   5880
cgttctacgt gggtataaga ggcgcgacca gcgtcggtac cgtcgcagtc ttcggtctga   5940
ccaccgtaga acgcagcctc aggacctcca tagaagacac cgggaccgat ccagcctccg   6000
cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg taagtaccgc   6060
ctatagagtc tataggccca cccccttggc ttcttatgca tgctatactg tttttggctt   6120
ggggtctata cacccccgct tcctcatgtt ataggtgatg gtatagctta gcctataggt   6180
gtgggttatt gaccattatt gaccactccc ctattggtga cgatactttc cattactaat   6240
ccataacatg gctctttgcc acaactctct ttattggcta tatgccaata cactgtcctt   6300
cagagactga cacggactct gtatttttac aggatggggt ctcatttatt atttacaaat   6360
tcacatatac aacaccaccg tccccagtgc ccgcagtttt tattaaacat aacgtgggat   6420
ctccacgcga atctcgggta cgtgttccgg acatgggctc ttctccggta gcggcggagc   6480
ttctacatcc gagccctgct cccatgcctc cagcgactca tggtcgctcg gcagctcctt   6540
gctcctaaca gtggaggcca gacttaggca cagcacgatg cccaccacca ccagtgtgcc   6600
gcacaaggcc gtggcggtag ggtatgtgtc tgaaaatgag ctcggggagc gggcttgcac   6660
cgctgacgca tttggaagac ttaaggcagc ggcagaagaa gatgcaggca gctgagttgt   6720
tgtgttctga taagagtcag aggtaactcc cgttgcggtg ctgttaacgg tggagggcag   6780
tgtagtctga gcagtactcg ttgctgccgc gcgcgccacc agacataata gctgacagac   6840
taacagactg ttcctttcca tgggtctttt ctgcagtcac cgtccttgac acgaagcttc   6900
gcgacgtacg ttcgaacccg ggcacgtgcg gacc                               6934
<210>  12
<211>  119
<212>  PRT
<213>  ˹
<220>  
<223>  HEL VH
<400>  12
Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asp Ser Lys Asn Ala Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Pro Gly Trp Tyr Ala Ala Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 
<210>  13
<211>  107
<212>  PRT
<213>  ˹
<220>  
<223>  HEL VL
<400>  13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Leu Pro Ala Phe 
                85                  90                  95      
Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105         
<210>  14
<211>  227
<212>  PRT
<213>  ˹
<220>  
<223>  IgG1-LALA-Fc-
<400>  14
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly Lys 
225         
<210>  15
<211>  120
<212>  PRT
<213>  ˹
<220>  
<223>  HER2¡4D5 VH
<400>  15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 
<210>  16
<211>  107
<212>  PRT
<213>  ˹
<220>  
<223>  HER2¡4D5 VL
<400>  16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         
<210>  17
<211>  124
<212>  PRT
<213>  ˹
<220>  
<223>  BCMA¡ADI384-56 VH
<400>  17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asp Ser Ser Ser Ile Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ser Pro Val Arg Asp Ser Phe Gly Ser Ile Ala Phe Asp 
            100                 105                 110         
Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 
<210>  18
<211>  107
<212>  PRT
<213>  ˹
<220>  
<223>  BCMA¡ADI384-56 VL
<400>  18
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Ser Ala Leu Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         
<210>  19
<211>  330
<212>  PRT
<213>  ˹
<220>  
<223>  IgG1-LALA-CH-
<400>  19
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 
<210>  20
<211>  107
<212>  PRT
<213>  ˹
<220>  
<223>  IgCL
<400>  20
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         
<210>  21
<211>  450
<212>  PRT
<213>  ˹
<220>  
<223>  MGAH22HC
<400>  21
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Val Ser Arg Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Ala Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Val Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Leu Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Pro Glu Glu Gln Tyr Asn Ser Thr Leu Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Leu Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
Gly Lys 
    450 
<210>  22
<211>  107
<212>  PRT
<213>  ˹
<220>  
<223>  MGAH22 VL
<400>  22
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         
<210>  23
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  Y88A3 CDR1(Kabat)
<400>  23
Tyr Asn Phe Thr Arg Val Tyr Met Gly 
1               5                   
<210>  24
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  Y88A3 CDR2Kabatţ
<400>  24
Ala Ile Ser Trp Gly Gly Gly Ser Thr His 
1               5                   10  
<210>  25
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  Y88A3 CDR3Kabatţ
<400>  25
Ala Leu Asp Asp Tyr Ser Gly Val Leu Ser Pro 
1               5                   10      
<210>  26
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  Y95H1 CDR1Kabatţ
<400>  26
Phe Thr Phe Asp Met Tyr Val Met Thr 
1               5                   
<210>  27
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  Y95H1 CDR2Kabatţ
<400>  27
Ala Ile His Glu Asp Gly Gly Lys Thr Asp 
1               5                   10  
<210>  28
<211>  13
<212>  PRT
<213>  ˹
<220>  
<223>  Y95H1 CDR3Kabatţ
<400>  28
Val Ala Tyr Asp Tyr Ser Tyr Ser Glu Trp Tyr Asp Tyr 
1               5                   10              
<210>  29
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  Y99F6 CDR1Kabatţ
<400>  29
Phe Lys Phe Asn Ser Phe Val Met Thr 
1               5                   
<210>  30
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  Y99F6 CDR2Kabatţ
<400>  30
Ala Ile His Glu Asp Gly Gly Lys Thr Asp 
1               5                   10  
<210>  31
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  Y99F6 CDR3Kabatţ
<400>  31
Ala Ala Val Thr His Ser Leu Tyr Asp Tyr 
1               5                   10  
<210>  32
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  Y100D6 CDR1Kabatţ
<400>  32
Phe Thr Phe Asp Trp Tyr Trp Met Gly 
1               5                   
<210>  33
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  Y100D6 CDR2Kabatţ
<400>  33
Ala Ile His Asp Asp Gly Thr Glu Thr His 
1               5                   10  
<210>  34
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  Y100D6 CDR3Kabatţ
<400>  34
Ala Thr Val Arg Ser Asp Ser Tyr Tyr Asp Tyr 
1               5                   10      
