                         SEQUENCE LISTING

<110>  Obsidian Therapeutics, Inc.
 
<120>  Compositions And Methods For Expansion Of Tumor Infiltrating 
       Lymphocytes

<130>  108407-1291323 (020WO1)

<150>  63/153,367
<151>  2021-02-24

<150>  63/139,305
<151>  2021-01-19

<150>  63/226,114
<151>  2021-07-27

<150>  63/244,166
<151>  2021-09-14

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  159
<212>  PRT
<213>  E. coli

<400>  1

Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Arg Val Ile Gly Met 
1               5                   10                  15      


Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys 
            20                  25                  30          


Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu 
        35                  40                  45              


Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser 
    50                  55                  60                  


Gln Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu 
65                  70                  75                  80  


Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly 
                85                  90                  95      


Gly Arg Val Tyr Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu 
            100                 105                 110         


Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr 
        115                 120                 125             


Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp 
    130                 135                 140                 


Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155                 


<210>  2
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210>  3
<211>  3919
<212>  DNA
<213>  Homo Sapiens

<400>  3
agtcccagac agaacctact atgtgcggcg gcagctgggg cgggaaggcg ggagctgggg       60

gcgctggggg cgctgcggcc gctgcggccg ctgcagccgc tgcagcgcca gggtccacct      120

ggtcggctgc acctgtggag gaggaggtgg atttcaggct tcccgtagac tggaagaatc      180

ggctcaaaac cgcttgcctc gcaggggctg agctggaggc agcgaggccg cccgacgcag      240

gcttccggcg agacatggca gggcaaggat ggcagcccgg cggcagggcc tggcgaggag      300

cgcgagcccg cggccgcagt tcccaggcgt ctgcgggcgc gagcacgccg cgaccctgcg      360

tgcgccgggg cgggggggcg gggcctcgcc tgcacaaatg gggacgaggg gggcggggcg      420

gccacaattt cgcgccaaac ttgaccgcgc gttctgctgt aacgagcggg ctcggaggtc      480

ctcccgctgc tgtcatggtt ggttcgctaa actgcatcgt cgctgtgtcc cagaacatgg      540

gcatcggcaa gaacggggac ctgccctggc caccgctcag gaatgaattc agatatttcc      600

agagaatgac cacaacctct tcagtagaag gtaaacagaa tctggtgatt atgggtaaga      660

agacctggtt ctccattcct gagaagaatc gacctttaaa gggtagaatt aatttagttc      720

tcagcagaga actcaaggaa cctccacaag gagctcattt tctttccaga agtctagatg      780

atgccttaaa acttactgaa caaccagaat tagcaaataa agtagacatg gtctggatag      840

ttggtggcag ttctgtttat aaggaagcca tgaatcaccc aggccatctt aaactatttg      900

tgacaaggat catgcaagac tttgaaagtg acacgttttt tccagaaatt gatttggaga      960

aatataaact tctgccagaa tacccaggtg ttctctctga tgtccaggag gagaaaggca     1020

ttaagtacaa atttgaagta tatgagaaga atgattaata tgaaggtgtt ttctagttta     1080

agttgttccc cctccctctg aaaaaagtat gtatttttac attagaaaag gttttttgtt     1140

gactttagat ctataattat ttctaagcaa ctagttttta ttccccacta ctcttgtctc     1200

tatcagatac catttatgag acattcttgc tataactaag tgcttctcca agaccccaac     1260

tgagtcccca gcacctgcta cagtgagctg ccattccaca cccatcacat gtggcactct     1320

tgccagtcct tgacattgtc gggcttttca catgttggta atatttatta aagatgaaga     1380

tccacatacc cttcaactga gcagtttcac tagtggaaat accaaaagct tcctacgtgt     1440

atatccagag gtttgtagat aaatgttgcc accttgtttg taacagtgaa aaattgaaaa     1500

caacctggaa gtccagtgat gggaaaatga gtatgtttct gtcttagatt ggggaaccca     1560

aagcagattg caagactgaa atttcagtga aagcagtgta tttgctaggt cataccagaa     1620

atcatcaatt gaggtacgga gaaactgaac tgagaaggta agaaaagcaa tttaaagtca     1680

gcgagcaggt tctcattgat aacaagctcc atactgctga gatacaggga aatggagggg     1740

ggaaagctgg agtattgatc ccgcccccct ccttggttgt cagctccctg tcctgtgtgt     1800

gggcggaaca tagtccagct gctctatagc aagtctcagg tgtttgcagt aagaagctgc     1860

tggcatgcac gggaacagtg aatgccaaac acttaaagca attcgatgtt taagtatgta     1920

agttcttttt tttttagaca gcgtttcgct cttgttgccc aggctagcat gcaatggtgt     1980

gacctcggct tactgcaacc tccgccttcc cagattcaag cgattctcct gcctcaggct     2040

cccaagtagc taggaccagg tgcgcgccac cacgcccggc taatttttgt attttgtatt     2100

tttagtagag atggggtttc accatgttgg tcaggctagt ctcgaactcg tgaccgcaag     2160

cgattcaccc acctcagcct cccaaagtgc tgggattacc ggcttgagcc accacacccg     2220

gcacatcttc attcttttta tgtagtaaaa agtataaggc cacacatggt ttatttgaag     2280

tattttataa tttaaaaaaa tacagaagca ggaaaaccaa ttataagttc aagtgaggga     2340

tgatggttgc ttgaaccaaa gggttgcatg tagtaagaaa ttgtgattta agatatattt     2400

taaagttata agtagcagga tattctgatg gagtttgact ttggttttgg gcccagggag     2460

tttcagatgc ctttgagaaa tgaatgaagt agagagaaaa taaaagaaaa accagccagg     2520

cacagtggct cacacctgta atcccagcgc tttgggaggc taaggcaggc agatcacttg     2580

agaccagctt gggcaacatg gcaaagcccc atctctacaa aaaacacaaa aattagctgg     2640

gcattgtggc gcacacctgt attcccatct agtcaggaag ctgagatgga agaattaatt     2700

gagcccacga gttcaaggct gcagtgagtc gtgattgtgc cactgcactc cagccggggt     2760

gacagaagag accttgtctc gaaaaggaat ctgaaaacaa tggaaccatg ccttcataat     2820

tctagaaagt tattttcaac tgataaatct atattcaccc aaataatcaa gggtgaaggt     2880

aaaataatac atttttagac aagcaaagac tcaggggtta cctccatgtg ccctttttag     2940

ggaagctgtt ggagaaaata ctccagcaaa atgaaggagt acacaaacca gagaatgaca     3000

tgaatccagc aaataggatc caacacaggc aatattccag ctatggagct agctttaaaa     3060

aggaacagta aaaatattaa tcggttagct gggtggaatg gcccatgcct gtagtcccag     3120

ctactcagga ggctcagcag caggacgact tgagcccaag agttccagac cagcctggcc     3180

accttagtga gatcccttct cttaaaaata ataacttatt gccagatttg gggcatttgg     3240

aaagaagttc attgaagata aagcaaaagt aaaaaaaaaa aaaaaaaaaa caaggggaaa     3300

gggttggtta ggcaatcatt ctagggcaga aagaagtaca ggataggaag agcataatac     3360

actgtttttc tcaacaagga gcagtatgta cacagtcata atgatgtgac tgcttagccc     3420

ctaaatatgg taactactct gggacaatat gggaggaaaa gtgaagattg tgatggtgta     3480

agagctaaat cctcatctgt catatccaga aatcactata taatatataa taatgaaatg     3540

actaagttat gtgaggaaaa aaacagaaga cattgctaaa agagttaaaa gtcattgctc     3600

tggagaatta ggagggatgg ggcaggggac tgttaggatg cattataaac tgaaaagcct     3660

ttttaaaatt ttatgtatta atatatgcat tcacttgaaa aactaaaaaa aaacaataat     3720

ttggaaaaac ccatgaaggt aactaacgga aggaaaaact aagagaatga aaagtatttg     3780

cctctggaaa gaacaactgg caggactgtt gttttcattg taagactttt ggagccattt     3840

aattgtactt aaccattttc atctatttct ttaataagaa caattccatc ttaataaaga     3900

gttacacttg ttaataagt                                                  3919


<210>  4
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  4

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  5
<211>  327
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro 
1               5                   10                  15      


Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu 
            20                  25                  30          


Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp 
        35                  40                  45              


Leu Asn Leu Val Gln Asn Phe Gln Met Lys His Glu Val Leu Cys Arg 
    50                  55                  60                  


Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His 
65                  70                  75                  80  


Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu 
                85                  90                  95      


Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala 
            100                 105                 110         


Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn 
        115                 120                 125             


Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys 
    130                 135                 140                 


His Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu 
145                 150                 155                 160 


Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr 
                165                 170                 175     


Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu 
            180                 185                 190         


Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys 
        195                 200                 205             


Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala 
    210                 215                 220                 


Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro 
225                 230                 235                 240 


Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln 
                245                 250                 255     


Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met 
            260                 265                 270         


Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile 
        275                 280                 285             


Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu 
    290                 295                 300                 


Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp 
305                 310                 315                 320 


Gln Ala Leu Ala Glu Gln Gln 
                325         


<210>  6
<211>  875
<212>  PRT
<213>  Homo Sapiens

<400>  6

Met Glu Arg Ala Gly Pro Ser Phe Gly Gln Gln Arg Gln Gln Gln Gln 
1               5                   10                  15      


Pro Gln Gln Gln Lys Gln Gln Gln Arg Asp Gln Asp Ser Val Glu Ala 
            20                  25                  30          


Trp Leu Asp Asp His Trp Asp Phe Thr Phe Ser Tyr Phe Val Arg Lys 
        35                  40                  45              


Ala Thr Arg Glu Met Val Asn Ala Trp Phe Ala Glu Arg Val His Thr 
    50                  55                  60                  


Ile Pro Val Cys Lys Glu Gly Ile Arg Gly His Thr Glu Ser Cys Ser 
65                  70                  75                  80  


Cys Pro Leu Gln Gln Ser Pro Arg Ala Asp Asn Ser Ala Pro Gly Thr 
                85                  90                  95      


Pro Thr Arg Lys Ile Ser Ala Ser Glu Phe Asp Arg Pro Leu Arg Pro 
            100                 105                 110         


Ile Val Val Lys Asp Ser Glu Gly Thr Val Ser Phe Leu Ser Asp Ser 
        115                 120                 125             


Glu Lys Lys Glu Gln Met Pro Leu Thr Pro Pro Arg Phe Asp His Asp 
    130                 135                 140                 


Glu Gly Asp Gln Cys Ser Arg Leu Leu Glu Leu Val Lys Asp Ile Ser 
145                 150                 155                 160 


Ser His Leu Asp Val Thr Ala Leu Cys His Lys Ile Phe Leu His Ile 
                165                 170                 175     


His Gly Leu Ile Ser Ala Asp Arg Tyr Ser Leu Phe Leu Val Cys Glu 
            180                 185                 190         


Asp Ser Ser Asn Asp Lys Phe Leu Ile Ser Arg Leu Phe Asp Val Ala 
        195                 200                 205             


Glu Gly Ser Thr Leu Glu Glu Val Ser Asn Asn Cys Ile Arg Leu Glu 
    210                 215                 220                 


Trp Asn Lys Gly Ile Val Gly His Val Ala Ala Leu Gly Glu Pro Leu 
225                 230                 235                 240 


Asn Ile Lys Asp Ala Tyr Glu Asp Pro Arg Phe Asn Ala Glu Val Asp 
                245                 250                 255     


Gln Ile Thr Gly Tyr Lys Thr Gln Ser Ile Leu Cys Met Pro Ile Lys 
            260                 265                 270         


Asn His Arg Glu Glu Val Val Gly Val Ala Gln Ala Ile Asn Lys Lys 
        275                 280                 285             


Ser Gly Asn Gly Gly Thr Phe Thr Glu Lys Asp Glu Lys Asp Phe Ala 
    290                 295                 300                 


Ala Tyr Leu Ala Phe Cys Gly Ile Val Leu His Asn Ala Gln Leu Tyr 
305                 310                 315                 320 


Glu Thr Ser Leu Leu Glu Asn Lys Arg Asn Gln Val Leu Leu Asp Leu 
                325                 330                 335     


Ala Ser Leu Ile Phe Glu Glu Gln Gln Ser Leu Glu Val Ile Leu Lys 
            340                 345                 350         


Lys Ile Ala Ala Thr Ile Ile Ser Phe Met Gln Val Gln Lys Cys Thr 
        355                 360                 365             


Ile Phe Ile Val Asp Glu Asp Cys Ser Asp Ser Phe Ser Ser Val Phe 
    370                 375                 380                 


His Met Glu Cys Glu Glu Leu Glu Lys Ser Ser Asp Thr Leu Thr Arg 
385                 390                 395                 400 


Glu His Asp Ala Asn Lys Ile Asn Tyr Met Tyr Ala Gln Tyr Val Lys 
                405                 410                 415     


Asn Thr Met Glu Pro Leu Asn Ile Pro Asp Val Ser Lys Asp Lys Arg 
            420                 425                 430         


Phe Pro Trp Thr Thr Glu Asn Thr Gly Asn Val Asn Gln Gln Cys Ile 
        435                 440                 445             


Arg Ser Leu Leu Cys Thr Pro Ile Lys Asn Gly Lys Lys Asn Lys Val 
    450                 455                 460                 


Ile Gly Val Cys Gln Leu Val Asn Lys Met Glu Glu Asn Thr Gly Lys 
465                 470                 475                 480 


Val Lys Pro Phe Asn Arg Asn Asp Glu Gln Phe Leu Glu Ala Phe Val 
                485                 490                 495     


Ile Phe Cys Gly Leu Gly Ile Gln Asn Thr Gln Met Tyr Glu Ala Val 
            500                 505                 510         


Glu Arg Ala Met Ala Lys Gln Met Val Thr Leu Glu Val Leu Ser Tyr 
        515                 520                 525             


His Ala Ser Ala Ala Glu Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala 
    530                 535                 540                 


Ala Ala Val Val Pro Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser 
545                 550                 555                 560 


Phe Ser Asp Phe Glu Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile 
                565                 570                 575     


Arg Met Phe Thr Asp Leu Asn Leu Val Gln Asn Phe Gln Met Lys His 
            580                 585                 590         


Glu Val Leu Cys Arg Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys 
        595                 600                 605             


Asn Val Ala Tyr His Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys 
    610                 615                 620                 


Met Phe Ala Ala Leu Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp 
625                 630                 635                 640 


Leu Glu Ile Leu Ala Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp 
                645                 650                 655     


His Arg Gly Val Asn Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu 
            660                 665                 670         


Ala Gln Leu Tyr Cys His Ser Ile Met Glu His His His Phe Asp Gln 
        675                 680                 685             


Cys Leu Met Ile Leu Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu 
    690                 695                 700                 


Ser Ile Glu Glu Tyr Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile 
705                 710                 715                 720 


Leu Ala Thr Asp Leu Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe 
                725                 730                 735     


Glu Leu Ile Arg Lys Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys 
            740                 745                 750         


Glu Leu Phe Leu Ala Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile 
        755                 760                 765             


Thr Lys Pro Trp Pro Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr 
    770                 775                 780                 


Glu Phe Phe Asp Gln Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu 
785                 790                 795                 800 


Pro Thr Asp Leu Met Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met 
                805                 810                 815     


Gln Val Gly Phe Ile Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu 
            820                 825                 830         


Thr His Val Ser Glu Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys 
        835                 840                 845             


Asn Arg Gln Lys Trp Gln Ala Leu Ala Glu Gln Gln Glu Lys Met Leu 
    850                 855                 860                 


Ile Asn Gly Glu Ser Gly Gln Ala Lys Arg Asn 
865                 870                 875 


<210>  7
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  7

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  8
<211>  1492
<212>  DNA
<213>  Homo Sapiens

<400>  8
acacagtgca ggcgcccaag ccgccgccgc cagatcggtg ccgattcctg ccctgccccg       60

accgccagcg cgaccatgtc ccatcactgg gggtacggca aacacaacgg acctgagcac      120

tggcataagg acttccccat cccctgtctg tttcctatga tcaagcaact tccctgagga      180

tcctcaacaa tggtcatgct ttcaacgtgg agtttgatga ctctcaggac aaagcagtgc      240

tcaagggagg acccctggat ggcacttaca gattgattca gtttcacttt cactggggtt      300

cacttgatgg acaaggttca gagcatactg tggataaaaa gaaatatgct gcagaacttc      360

acttggttca ctggaacacc aaatatgggg attttgggaa agctgtgcag caacctgatg      420

gactggccgt tctaggtatt tttttgaagg ttggcagcgc taaaccgggc cttcagaaag      480

ttgttgatgt gctggattcc attaaaacaa agggcaagag tgctgacttc actaacttcg      540

atcctcgtgg cctccttcct gaatccttgg attactggac ctacccaggc tcactgacca      600

cccctcctct tctggaatgt gtgacctgga ttgtgctcaa ggaacccatc agcgtcagca      660

gcgagcaggt gttgaaattc cgtaaactta acttcaatgg ggagggtgaa cccgaagaac      720

tgatggtgga caactggcgc ccagctcagc cactgaagaa caggcaaatc aaagcttcct      780

tcaaataaga tggtcccata gtctgtatcc aaataatgaa tcttcgggtg tttcccttta      840

gctaagcaca gatctacctt ggtgatttgg accctggttg ctttgtgtct agttttctag      900

acccttcatc tcttacttga tagacttact aataaaatgt gaagactaga ccaattgtca      960

tgcttgacac aactgctgtg gctggttggt gctttgttta tggtagtagt ttttctgtaa     1020

cacagaatat aggataagaa ataagaataa agtaccttga ctttgttcac agcatgtagg     1080

gtgatgagca ctcacaattg ttgactaaaa tgctgctttt aaaacatagg aaagtagaat     1140

ggttgagtgc aaatccatag cacaagataa attgagctag ttaaggcaaa tcaggtaaaa     1200

tagtcatgat tctatgtaat gtaaaccaga aaaaataaat gttcatgatt tcaagatgtt     1260

atattaaaga aaaactttaa aaattattat atatttatag caaagttatc ttaaatatga     1320

attctgttgt aatttaatga cttttgaatt acagagatat aaatgaagta ttatctgtaa     1380

aaattgttat aattagagtt gtgatacaga gtatatttcc attcagacaa tatatcataa     1440

cttaataaat attgtatttt agatatattc tctaataaaa ttcagaattc ta             1492


<210>  9
<211>  595
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  10
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys 
            20          


<210>  11
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgt                                                                  66


<210>  12
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  12

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  13
<211>  342
<212>  DNA
<213>  Homo Sapiens

<400>  13
aattgggtaa atgttatcag tgatctcaag aagatagagg atctcatcca gtccatgcat       60

attgatgcca cgctgtacac agaaagcgat gtgcatccta gctgtaaggt gacagcgatg      120

aagtgttttc ttttggagct gcaggtaatt agtcttgagt ccggcgatgc cagcattcat      180

gataccgtag aaaacttgat tatcctggcc aacaattctc tgtcctcaaa cggaaacgta      240

accgagagcg gttgtaaaga atgtgaagaa ctggaagaaa agaacatcaa ggagtttctg      300

caatcattcg ttcacatcgt acaaatgttc ataaatacgt ca                         342


<210>  14
<211>  30
<212>  PRT
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25                  30  


<210>  15
<211>  90
<212>  DNA
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
ggatctggtt ctggttccgg aagtggatct ggttcagggt ccggtagtgg atctgggtca       60

ggaagtggaa gcggtagtgg gtctggatct                                        90


<210>  16
<211>  8
<212>  PRT
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Lys Gln Glu His Phe Pro Asp Asn 
1               5               


<210>  17
<211>  24
<212>  DNA
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
aaacaagagc actttcctga taac                                              24


<210>  18
<211>  21
<212>  PRT
<213>  ARtificial SEquence

<220>
<223>  Synthetic Construct

<400>  18

Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
1               5                   10                  15      


Val Ile Cys Cys Leu 
            20      


<210>  19
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
ctgttgccga gctgggcgat tacgcttatc agtgtaaacg gcatctttgt aatatgctgt       60

ctg                                                                     63


<210>  20
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg Asn Glu Arg 
1               5                   10                  15      


Leu Arg Arg Glu Ser Val Arg Pro Val 
            20                  25  


<210>  21
<211>  75
<212>  DNA
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
acctactgct tcgcaccaag gtgccgggag agaaggagaa atgaaagact gagaagggag       60

agcgtgagac ctgtg                                                        75


<210>  22
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Ala Arg Asn Glu Arg 
1               5                   10                  15      


Leu Arg Arg Glu Thr Val Arg Pro Val 
            20                  25  


<210>  23
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
acctactgct tcgcaccaag gtgccgggag agagcaagaa atgaaagact gagaagggag       60

accgtgagac ctgtg                                                        75


<210>  24
<211>  2
<212>  PRT
<213>  Artificial SEquence

<220>
<223>  Synthetic Construct

<400>  24

Gly Ser 
1       


<210>  25
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25
ggatcc                                                                   6


<210>  26
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His 
1               5                   10                  15      


Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile 
            20                  25                  30          


Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val 
        35                  40                  45              


Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala 
    50                  55                  60                  


Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly 
65                  70                  75                  80  


Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp 
                85                  90                  95      


Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Asp 
            100                 105                 110         


Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn Phe Asp Pro 
        115                 120                 125             


Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr Pro Gly Ser 
    130                 135                 140                 


Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile Val Leu Lys 
145                 150                 155                 160 


Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe Arg Lys Leu 
                165                 170                 175     


Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val Asp Asn Trp 
            180                 185                 190         


Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala Ser Phe Lys 
        195                 200                 205             


<210>  27
<211>  777
<212>  DNA
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
tcccatcact gggggtacgg caaacacaac ggacctgagc actggcataa ggacttcccc       60

attgccaagg gagagcgcca gtcccctgtt gacatcgaca ctcatacagc caagtatgac      120

ccttccctga agcccctgtc tgtttcctat gatcaagcaa cttccctgag aatcctcaac      180

aatggtcatg ctttcaacgt ggagtttgat gactctcagg acaaagcagt gctcaaggga      240

ggacccctgg atggcactta cagattgatt cagtttcact ttcactgggg ttcacttgat      300

ggacaaggtt cagagcatac tgtggataaa aagaaatatg ctgcagaact tcacttggtt      360

cactggaaca ccaaatatgg ggattttggg aaagctgtgc agcaacctga tggactggcc      420

gttctaggta tttttttgaa ggttggcagc gctaaaccgg gccatcagaa agttgttgat      480

gtgctggatt ccattaaaac aaagggcaag agtgctgact tcactaactt cgatcctcgt      540

ggcctccttc ctgaatccct ggattactgg acctacccag gctcactgac cacccctcct      600

cttctggaat gtgtgacctg gattgtgctc aaggaaccca tcagcgtcag cagcgagcag      660

gtgttgaaat tccgtaaact taacttcaat ggggagggtg aacccgaaga actgatggtg      720

gacaactggc gcccagctca gccactgaag aacaggcaaa tcaaagcttc cttcaaa         777


<210>  28
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn Leu Leu 
                165                 170                 175     


Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile 
            180                 185                 190         


Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg 
        195                 200                 205             


Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val Gly Ser 
    210                 215                 220         


<210>  29
<211>  666
<212>  DNA
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgtaatt gggtaaatgt tatcagtgat ctcaagaaga tagaggatct catccagtcc      120

atgcatattg atgccacgct gtacacagaa agcgatgtgc atcctagctg taaggtgaca      180

gcgatgaagt gttttctttt ggagctgcag gtaattagtc ttgagtccgg cgatgccagc      240

attcatgata ccgtagaaaa cttgattatc ctggccaaca attctctgtc ctcaaacgga      300

aacgtaaccg agagcggttg taaagaatgt gaagaactgg aagaaaagaa catcaaggag      360

tttctgcaat cattcgttca catcgtacaa atgttcataa atacgtcagg atctggttct      420

ggttccggaa gtggatctgg ttcagggtcc ggtagtggat ctgggtcagg aagtggaagc      480

ggtagtgggt ctggatctaa acaagagcac tttcctgata acctgttgcc gagctgggcg      540

attacgctta tcagtgtaaa cggcatcttt gtaatatgct gtctgaccta ctgcttcgca      600

ccaaggtgcc gggagagaag gagaaatgaa agactgagaa gggagagcgt gagacctgtg      660

ggatcc                                                                 666


<210>  30
<211>  430
<212>  PRT
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn Leu Leu 
                165                 170                 175     


Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile 
            180                 185                 190         


Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg 
        195                 200                 205             


Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val Gly Ser Ser His 
    210                 215                 220                 


His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His Lys Asp 
225                 230                 235                 240 


Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile Asp Thr 
                245                 250                 255     


His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val Ser Tyr 
            260                 265                 270         


Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala Phe Asn 
        275                 280                 285             


Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly Gly Pro 
    290                 295                 300                 


Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp Gly Ser 
305                 310                 315                 320 


Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Asp Ser Ile 
                325                 330                 335     


Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn Phe Asp Pro Arg Gly 
            340                 345                 350         


Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr Pro Gly Ser Leu Thr 
        355                 360                 365             


Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile Val Leu Lys Glu Pro 
    370                 375                 380                 


Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe Arg Lys Leu Asn Phe 
385                 390                 395                 400 


Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val Asp Asn Trp Arg Pro 
                405                 410                 415     


Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala Ser Phe Lys 
            420                 425                 430 


<210>  31
<211>  1443
<212>  DNA
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgtaatt gggtaaatgt tatcagtgat ctcaagaaga tagaggatct catccagtcc      120

atgcatattg atgccacgct gtacacagaa agcgatgtgc atcctagctg taaggtgaca      180

gcgatgaagt gttttctttt ggagctgcag gtaattagtc ttgagtccgg cgatgccagc      240

attcatgata ccgtagaaaa cttgattatc ctggccaaca attctctgtc ctcaaacgga      300

aacgtaaccg agagcggttg taaagaatgt gaagaactgg aagaaaagaa catcaaggag      360

tttctgcaat cattcgttca catcgtacaa atgttcataa atacgtcagg atctggttct      420

ggttccggaa gtggatctgg ttcagggtcc ggtagtggat ctgggtcagg aagtggaagc      480

ggtagtgggt ctggatctaa acaagagcac tttcctgata acctgttgcc gagctgggcg      540

attacgctta tcagtgtaaa cggcatcttt gtaatatgct gtctgaccta ctgcttcgca      600

ccaaggtgcc gggagagaag gagaaatgaa agactgagaa gggagagcgt gagacctgtg      660

ggatcctccc atcactgggg gtacggcaaa cacaacggac ctgagcactg gcataaggac      720

ttccccattg ccaagggaga gcgccagtcc cctgttgaca tcgacactca tacagccaag      780

tatgaccctt ccctgaagcc cctgtctgtt tcctatgatc aagcaacttc cctgagaatc      840

ctcaacaatg gtcatgcttt caacgtggag tttgatgact ctcaggacaa agcagtgctc      900

aagggaggac ccctggatgg cacttacaga ttgattcagt ttcactttca ctggggttca      960

cttgatggac aaggttcaga gcatactgtg gataaaaaga aatatgctgc agaacttcac     1020

ttggttcact ggaacaccaa atatggggat tttgggaaag ctgtgcagca acctgatgga     1080

ctggccgttc taggtatttt tttgaaggtt ggcagcgcta aaccgggcca tcagaaagtt     1140

gttgatgtgc tggattccat taaaacaaag ggcaagagtg ctgacttcac taacttcgat     1200

cctcgtggcc tccttcctga atccctggat tactggacct acccaggctc actgaccacc     1260

cctcctcttc tggaatgtgt gacctggatt gtgctcaagg aacccatcag cgtcagcagc     1320

gagcaggtgt tgaaattccg taaacttaac ttcaatgggg agggtgaacc cgaagaactg     1380

atggtggaca actggcgccc agctcagcca ctgaagaaca ggcaaatcaa agcttccttc     1440

aaa                                                                   1443


<210>  32
<211>  51
<212>  DNA
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
atgtggctgc agtctctgct cctcttgggg actgtcgcct gttctatttc a                51


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser 
    


<210>  34
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
caaggacagg atcgacatat gattcggatg cgccaactga tagatatagt cgatcaactc       60

aagaattatg tgaatgactt ggtccctgag tttctgccgg ctccagagga cgttgaaaca      120

aactgtgaat ggtcagcgtt ttcatgtttt caaaaggcac agctcaagtc cgccaataca      180

ggcaataacg agcggattat aaatgtctca attaaaaagc tcaagcgcaa acccccttca      240

acgaatgctg gtcgccgcca gaaacacagg ttgacctgtc cctcctgtga ctcatacgag      300

aagaaacctc ccaaggaatt tctcgaacgc tttaagtcac tcttgcagaa gatgattcat      360

cagcacttga gtagccggac acatggttca gaggatagt                             399


<210>  35
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser 
    130             


<210>  36
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
gagtctaagt atggcccacc gtgtcccccc tgccca                                 36


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  38
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
gcacctgagt tcctcggagg cccctctgta ttcctgtttc ccccaaagcc caaggatact       60

cttatgatct cacgcactcc ggaagtaacc tgcgtggtgg tggatgtgag tcaggaagac      120

cccgaagtcc agtttaattg gtacgtggac ggggttgagg tacataacgc caaaacgaaa      180

cctcgggagg agcaattcaa ttccacttac cgggttgtat cagtcctgac tgtactgcat      240

caagattggc tcaacgggaa agagtacaag tgtaaggtta gtaataaagg gctgccgtct      300

agtattgaga aaacgatcag taaggctaaa gggcagccaa gagagccaca agtatatacc      360

ctgccaccct ctcaggagga gatgactaaa aaccaagtgt cactgacctg ccttgttaag      420

ggtttttacc catctgatat agcagtagag tgggaatcca atggacagcc agagaacaat      480

tataagacta cacctcccgt ccttgatagt gacggctcct tcttcttgta ttctcgactt      540

acagttgata agtcccgctg gcaggagggt aatgtcttta gctgcagtgt aatgcacgaa      600

gctcttcata atcactacac acaaaaatca ttgagcctgt ctctgggaaa g               651


<210>  39
<211>  217
<212>  PRT
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  40
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40
atggccttga ttgtgctcgg cggagttgca ggcctgctcc tttttattgg actcggaata       60

tttttc                                                                  66


<210>  41
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  42
<211>  9
<212>  DNA
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
ggatctgga                                                                9


<210>  43
<211>  3
<212>  PRT
<213>  ARtificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Gly Ser Gly 
1           


<210>  44
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacct          57


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  46
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
atggagtacg ctagtgatgc gtccttggac cccgaggcgc catggccacc ggccccgcga       60

gctcgagcct gtcgagtgct gccatgggct ctggtcgctg ggttgctcct ccttctgctt      120

ttggccgcgg cttgtgcagt gtttcttgct tgcccgtggg cagttagcgg tgctcgcgca      180

tctcccggaa gcgcggcgag tcctcgactc agggaaggtc cggagctgag cccagatgac      240

cccgccggtt tgctggacct ccgccaagga atgttcgctc aactcgttgc gcaaaacgta      300

cttcttatag acggccctct tagttggtac agtgacccag gattggctgg cgttagtttg      360

acaggcggac tcagttacaa ggaggatact aaggaactgg tagtcgctaa ggctggggta      420

tactacgtgt tctttcaact cgaactgaga agggtggttg cgggagaagg atctggaagt      480

gtatctctcg ccctgcacct ccaacccctc agaagtgccg ccggagcggc cgcccttgcc      540

cttactgtcg acctgccccc ggcttcttca gaagcgcgaa atagtgcatt cggcttccag      600

gggcgccttt tgcacttgag cgctggacag cgcctcgggg tccacctcca cacggaagcg      660

cgggcgaggc acgcttggca actcacacaa ggtgcgacgg ttctcggctt gtttagggtt      720

acgcctgaga taccggctgg cctcccatct ccaagatccg ag                         762


<210>  47
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  48
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
taa                                                                      3


<210>  49
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
atgtggctgc agtctctgct cctcttgggg actgtcgcct gttctatttc acaaggacag       60

gatcgacata tgattcggat gcgccaactg atagatatag tcgatcaact caagaattat      120

gtgaatgact tggtccctga gtttctgccg gctccagagg acgttgaaac aaactgtgaa      180

tggtcagcgt tttcatgttt tcaaaaggca cagctcaagt ccgccaatac aggcaataac      240

gagcggatta taaatgtctc aattaaaaag ctcaagcgca aacccccttc aacgaatgct      300

ggtcgccgcc agaaacacag gttgacctgt ccctcctgtg actcatacga gaagaaacct      360

cccaaggaat ttctcgaacg ctttaagtca ctcttgcaga agatgattca tcagcacttg      420

agtagccgga cacatggttc agaggatagt gagtctaagt atggcccacc gtgtcccccc      480

tgcccagcac ctgagttcct cggaggcccc tctgtattcc tgtttccccc aaagcccaag      540

gatactctta tgatctcacg cactccggaa gtaacctgcg tggtggtgga tgtgagtcag      600

gaagaccccg aagtccagtt taattggtac gtggacgggg ttgaggtaca taacgccaaa      660

acgaaacctc gggaggagca attcaattcc acttaccggg ttgtatcagt cctgactgta      720

ctgcatcaag attggctcaa cgggaaagag tacaagtgta aggttagtaa taaagggctg      780

ccgtctagta ttgagaaaac gatcagtaag gctaaagggc agccaagaga gccacaagta      840

tataccctgc caccctctca ggaggagatg actaaaaacc aagtgtcact gacctgcctt      900

gttaagggtt tttacccatc tgatatagca gtagagtggg aatccaatgg acagccagag      960

aacaattata agactacacc tcccgtcctt gatagtgacg gctccttctt cttgtattct     1020

cgacttacag ttgataagtc ccgctggcag gagggtaatg tctttagctg cagtgtaatg     1080

cacgaagctc ttcataatca ctacacacaa aaatcattga gcctgtctct gggaaagatg     1140

gccttgattg tgctcggcgg agttgcaggc ctgctccttt ttattggact cggaatattt     1200

ttcggatctg gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac     1260

cctggaccta tggagtacgc tagtgatgcg tccttggacc ccgaggcgcc atggccaccg     1320

gccccgcgag ctcgagcctg tcgagtgctg ccatgggctc tggtcgctgg gttgctcctc     1380

cttctgcttt tggccgcggc ttgtgcagtg tttcttgctt gcccgtgggc agttagcggt     1440

gctcgcgcat ctcccggaag cgcggcgagt cctcgactca gggaaggtcc ggagctgagc     1500

ccagatgacc ccgccggttt gctggacctc cgccaaggaa tgttcgctca actcgttgcg     1560

caaaacgtac ttcttataga cggccctctt agttggtaca gtgacccagg attggctggc     1620

gttagtttga caggcggact cagttacaag gaggatacta aggaactggt agtcgctaag     1680

gctggggtat actacgtgtt ctttcaactc gaactgagaa gggtggttgc gggagaagga     1740

tctggaagtg tatctctcgc cctgcacctc caacccctca gaagtgccgc cggagcggcc     1800

gcccttgccc ttactgtcga cctgcccccg gcttcttcag aagcgcgaaa tagtgcattc     1860

ggcttccagg ggcgcctttt gcacttgagc gctggacagc gcctcggggt ccacctccac     1920

acggaagcgc gggcgaggca cgcttggcaa ctcacacaag gtgcgacggt tctcggcttg     1980

tttagggtta cgcctgagat accggctggc ctcccatctc caagatccga gggatcctaa     2040


<210>  50
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
            20                  25                  30          


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
        35                  40                  45              


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
    50                  55                  60                  


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
65                  70                  75                  80  


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
                85                  90                  95      


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
            100                 105                 110         


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
        115                 120                 125             


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
    130                 135                 140                 


His Gly Ser Glu Asp Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        275                 280                 285             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Ala Leu Ile Val 
    370                 375                 380                 


Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe 
385                 390                 395                 400 


Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                405                 410                 415     


Val Glu Glu Asn Pro Gly Pro Met Glu Tyr Ala Ser Asp Ala Ser Leu 
            420                 425                 430         


Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg 
        435                 440                 445             


Val Leu Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu 
    450                 455                 460                 


Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly 
465                 470                 475                 480 


Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
                485                 490                 495     


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
            500                 505                 510         


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
        515                 520                 525             


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
    530                 535                 540                 


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
545                 550                 555                 560 


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
                565                 570                 575     


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
            580                 585                 590         


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
        595                 600                 605             


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
    610                 615                 620                 


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
625                 630                 635                 640 


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
                645                 650                 655     


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
            660                 665                 670         


Ser Pro Arg Ser Glu Gly Ser 
        675                 


<210>  51
<211>  9772
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51
gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa       60

cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc      120

accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc      180

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc      240

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt      300

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac      360

ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag      420

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa      480

actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg      540

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac      600

aaaatattaa cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc ggaaccccta      660

tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat      720

aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc      780

ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga      840

aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca      900

acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt      960

ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg     1020

gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc     1080

atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata     1140

acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt     1200

tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag     1260

ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca     1320

aactattaac tggcgaacta cttactctag cttcccggca acaattaata gactggatgg     1380

aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg     1440

ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag     1500

atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg     1560

aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag     1620

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     1680

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     1740

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     1800

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     1860

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     1920

caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     1980

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     2040

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     2100

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     2160

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     2220

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     2280

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     2340

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     2400

tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     2460

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     2520

agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc     2580

ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg     2640

gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac     2700

actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag     2760

gaaacagcta tgaccatgat tacgccaagc gcgcaattaa ccctcactaa agggaacaaa     2820

agctggagct gcaagcttaa tgtagtctta tgcaatactc ttgtagtctt gcaacatggt     2880

aacgatgagt tagcaacatg ccttacaagg agagaaaaag caccgtgcat gccgattggt     2940

ggaagtaagg tggtacgatc gtgccttatt aggaaggcaa cagacgggtc tgacatggat     3000

tggacgaacc actgaattgc cgcattgcag agatattgta tttaagtgcc tagctcgata     3060

cataaacggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg     3120

gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg     3180

tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat     3240

ctctagcagt ggcgcccgaa cagggacttg aaagcgaaag ggaaaccaga ggagctctct     3300

cgacgcagga ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg gcgactggtg     3360

agtacgccaa aaattttgac tagcggaggc tagaaggaga gagatgggtg cgagagcgtc     3420

agtattaagc gggggagaat tagatcgcga tgggaaaaaa ttcggttaag gccaggggga     3480

aagaaaaaat ataaattaaa acatatagta tgggcaagca gggagctaga acgattcgca     3540

gttaatcctg gcctgttaga aacatcagaa ggctgtagac aaatactggg acagctacaa     3600

ccatcccttc agacaggatc agaagaactt agatcattat ataatacagt agcaaccctc     3660

tattgtgtgc atcaaaggat agagataaaa gacaccaagg aagctttaga caagatagag     3720

gaagagcaaa acaaaagtaa gaccaccgca cagcaagcgg ccgctgatct tcagacctgg     3780

aggaggagat atgagggaca attggagaag tgaattatat aaatataaag tagtaaaaat     3840

tgaaccatta ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga gagaaaaaag     3900

agcagtggga ataggagctt tgttccttgg gttcttggga gcagcaggaa gcactatggg     3960

cgcagcgtca atgacgctga cggtacaggc cagacaatta ttgtctggta tagtgcagca     4020

gcagaacaat ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac tcacagtctg     4080

gggcatcaag cagctccagg caagaatcct ggctgtggaa agatacctaa aggatcaaca     4140

gctcctgggg atttggggtt gctctggaaa actcatttgc accactgctg tgccttggaa     4200

tgctagttgg agtaataaat ctctggaaca gatttggaat cacacgacct ggatggagtg     4260

ggacagagaa attaacaatt acacaagctt aatacactcc ttaattgaag aatcgcaaaa     4320

ccagcaagaa aagaatgaac aagaattatt ggaattagat aaatgggcaa gtttgtggaa     4380

ttggtttaac ataacaaatt ggctgtggta tataaaatta ttcataatga tagtaggagg     4440

cttggtaggt ttaagaatag tttttgctgt actttctata gtgaatagag ttaggcaggg     4500

atattcacca ttatcgtttc agacccacct cccaaccccg aggggacccg acaggcccga     4560

aggaatagaa gaagaaggtg gagagagaga cagagacaga tccattcgat tagtgaacgg     4620

atctcgacgg tatcgattag actgtagccc aggaatatgg cagctagatt gtacacattt     4680

agaaggaaaa gttatcttgg tagcagttca tgtagccagt ggatatatag aagcagaagt     4740

aattccagca gagacagggc aagaaacagc atacttcctc ttaaaattag caggaagatg     4800

gccagtaaaa acagtacata cagacaatgg cagcaatttc accagtacta cagttaaggc     4860

cgcctgttgg tgggcgggga tcaagcagga atttggcatt ccctacaatc cccaaagtca     4920

aggagtaata gaatctatga ataaagaatt aaagaaaatt ataggacagg taagagatca     4980

ggctgaacat cttaagacag cagtacaaat ggcagtattc atccacaatt ttaaaagaaa     5040

aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag caacagacat     5100

acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg tttattacag     5160

ggacagcaga gatccagttt ggctgcattg atcacgtgag gctccggtgc ccgtcagtgg     5220

gcagagcgca catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc     5280

ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc     5340

ctttttcccg agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt     5400

tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct     5460

ggcctcttta cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctgcagtac     5520

gtgattcttg atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct     5580

taaggagccc cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc     5640

gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt     5700

taaaattttt gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg     5760

ggccaagatc tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt     5820

gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga     5880

cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc     5940

gccccgccct gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg     6000

ccgcttcccg gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg     6060

gcgggtgagt cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt     6120

gactccactg agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt     6180

acgtcgtctt taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg     6240

gtggagactg aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt     6300

tttgagtttg gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt     6360

ccatttcagg tgtcgtgatc tagaggatca ctagtaccat gtggctgcag tctctgctcc     6420

tcttggggac tgtcgcctgt tctatttcac aaggacagga tcgacatatg attcggatgc     6480

gccaactgat agatatagtc gatcaactca agaattatgt gaatgacttg gtccctgagt     6540

ttctgccggc tccagaggac gttgaaacaa actgtgaatg gtcagcgttt tcatgttttc     6600

aaaaggcaca gctcaagtcc gccaatacag gcaataacga gcggattata aatgtctcaa     6660

ttaaaaagct caagcgcaaa cccccttcaa cgaatgctgg tcgccgccag aaacacaggt     6720

tgacctgtcc ctcctgtgac tcatacgaga agaaacctcc caaggaattt ctcgaacgct     6780

ttaagtcact cttgcagaag atgattcatc agcacttgag tagccggaca catggttcag     6840

aggatagtga gtctaagtat ggcccaccgt gtcccccctg cccagcacct gagttcctcg     6900

gaggcccctc tgtattcctg tttcccccaa agcccaagga tactcttatg atctcacgca     6960

ctccggaagt aacctgcgtg gtggtggatg tgagtcagga agaccccgaa gtccagttta     7020

attggtacgt ggacggggtt gaggtacata acgccaaaac gaaacctcgg gaggagcaat     7080

tcaattccac ttaccgggtt gtatcagtcc tgactgtact gcatcaagat tggctcaacg     7140

ggaaagagta caagtgtaag gttagtaata aagggctgcc gtctagtatt gagaaaacga     7200

tcagtaaggc taaagggcag ccaagagagc cacaagtata taccctgcca ccctctcagg     7260

aggagatgac taaaaaccaa gtgtcactga cctgccttgt taagggtttt tacccatctg     7320

atatagcagt agagtgggaa tccaatggac agccagagaa caattataag actacacctc     7380

ccgtccttga tagtgacggc tccttcttct tgtattctcg acttacagtt gataagtccc     7440

gctggcagga gggtaatgtc tttagctgca gtgtaatgca cgaagctctt cataatcact     7500

acacacaaaa atcattgagc ctgtctctgg gaaagatggc cttgattgtg ctcggcggag     7560

ttgcaggcct gctccttttt attggactcg gaatattttt cggatctgga gctactaact     7620

tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacctatg gagtacgcta     7680

gtgatgcgtc cttggacccc gaggcgccat ggccaccggc cccgcgagct cgagcctgtc     7740

gagtgctgcc atgggctctg gtcgctgggt tgctcctcct tctgcttttg gccgcggctt     7800

gtgcagtgtt tcttgcttgc ccgtgggcag ttagcggtgc tcgcgcatct cccggaagcg     7860

cggcgagtcc tcgactcagg gaaggtccgg agctgagccc agatgacccc gccggtttgc     7920

tggacctccg ccaaggaatg ttcgctcaac tcgttgcgca aaacgtactt cttatagacg     7980

gccctcttag ttggtacagt gacccaggat tggctggcgt tagtttgaca ggcggactca     8040

gttacaagga ggatactaag gaactggtag tcgctaaggc tggggtatac tacgtgttct     8100

ttcaactcga actgagaagg gtggttgcgg gagaaggatc tggaagtgta tctctcgccc     8160

tgcacctcca acccctcaga agtgccgccg gagcggccgc ccttgccctt actgtcgacc     8220

tgcccccggc ttcttcagaa gcgcgaaata gtgcattcgg cttccagggg cgccttttgc     8280

acttgagcgc tggacagcgc ctcggggtcc acctccacac ggaagcgcgg gcgaggcacg     8340

cttggcaact cacacaaggt gcgacggttc tcggcttgtt tagggttacg cctgagatac     8400

cggctggcct cccatctcca agatccgagg gatcctaaat cgggctagcg tcgacaatca     8460

acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt     8520

tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc     8580

tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc     8640

cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg     8700

gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc tccctattgc     8760

cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg     8820

cactgacaat tccgtggtgt tgtcggggaa gctgacgtcc tttccatggc tgctcgcctg     8880

tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc     8940

agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct     9000

tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcctggaa ttcgagctcg     9060

gtacctttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt tttaaaagaa     9120

aaggggggac tggaagggct aattcactcc caacgaagac aagatctgct ttttgcttgt     9180

actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac     9240

ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg     9300

ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct     9360

agcagtagta gttcatgtca tcttattatt cagtatttat aacttgcaaa gaaatgaata     9420

tcagagagtg agaggaactt gtttattgca gcttataatg gttacaaata aagcaatagc     9480

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa     9540

ctcatcaatg tatcttatca tgtctggctc tagctatccc gcccctaact ccgcccatcc     9600

cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta atttttttta     9660

tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag tgaggaggct     9720

tttttggagg cctagggacg tacccaattc gccctatagt gagtcgtatt ac             9772


<210>  52
<211>  8436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52
gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa       60

cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc      120

accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc      180

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc      240

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt      300

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac      360

ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag      420

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa      480

actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg      540

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac      600

aaaatattaa cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc ggaaccccta      660

tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat      720

aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc      780

ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga      840

aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca      900

acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt      960

ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg     1020

gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc     1080

atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata     1140

acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt     1200

tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag     1260

ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca     1320

aactattaac tggcgaacta cttactctag cttcccggca acaattaata gactggatgg     1380

aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg     1440

ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag     1500

atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg     1560

aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag     1620

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     1680

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     1740

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     1800

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     1860

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     1920

caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     1980

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     2040

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     2100

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     2160

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     2220

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     2280

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     2340

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     2400

tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     2460

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     2520

agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc     2580

ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg     2640

gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac     2700

actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag     2760

gaaacagcta tgaccatgat tacgccaagc gcgcaattaa ccctcactaa agggaacaaa     2820

agctggagct gcaagcttaa tgtagtctta tgcaatactc ttgtagtctt gcaacatggt     2880

aacgatgagt tagcaacatg ccttacaagg agagaaaaag caccgtgcat gccgattggt     2940

ggaagtaagg tggtacgatc gtgccttatt aggaaggcaa cagacgggtc tgacatggat     3000

tggacgaacc actgaattgc cgcattgcag agatattgta tttaagtgcc tagctcgata     3060

cataaacggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg     3120

gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg     3180

tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat     3240

ctctagcagt ggcgcccgaa cagggacttg aaagcgaaag ggaaaccaga ggagctctct     3300

cgacgcagga ctcggcttgc tgaagcgcgc acggcaagag gcgaggggcg gcgactggtg     3360

agtacgccaa aaattttgac tagcggaggc tagaaggaga gagatgggtg cgagagcgtc     3420

agtattaagc gggggagaat tagatcgcga tgggaaaaaa ttcggttaag gccaggggga     3480

aagaaaaaat ataaattaaa acatatagta tgggcaagca gggagctaga acgattcgca     3540

gttaatcctg gcctgttaga aacatcagaa ggctgtagac aaatactggg acagctacaa     3600

ccatcccttc agacaggatc agaagaactt agatcattat ataatacagt agcaaccctc     3660

tattgtgtgc atcaaaggat agagataaaa gacaccaagg aagctttaga caagatagag     3720

gaagagcaaa acaaaagtaa gaccaccgca cagcaagcgg ccgctgatct tcagacctgg     3780

aggaggagat atgagggaca attggagaag tgaattatat aaatataaag tagtaaaaat     3840

tgaaccatta ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga gagaaaaaag     3900

agcagtggga ataggagctt tgttccttgg gttcttggga gcagcaggaa gcactatggg     3960

cgcagcgtca atgacgctga cggtacaggc cagacaatta ttgtctggta tagtgcagca     4020

gcagaacaat ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac tcacagtctg     4080

gggcatcaag cagctccagg caagaatcct ggctgtggaa agatacctaa aggatcaaca     4140

gctcctgggg atttggggtt gctctggaaa actcatttgc accactgctg tgccttggaa     4200

tgctagttgg agtaataaat ctctggaaca gatttggaat cacacgacct ggatggagtg     4260

ggacagagaa attaacaatt acacaagctt aatacactcc ttaattgaag aatcgcaaaa     4320

ccagcaagaa aagaatgaac aagaattatt ggaattagat aaatgggcaa gtttgtggaa     4380

ttggtttaac ataacaaatt ggctgtggta tataaaatta ttcataatga tagtaggagg     4440

cttggtaggt ttaagaatag tttttgctgt actttctata gtgaatagag ttaggcaggg     4500

atattcacca ttatcgtttc agacccacct cccaaccccg aggggacccg acaggcccga     4560

aggaatagaa gaagaaggtg gagagagaga cagagacaga tccattcgat tagtgaacgg     4620

atctcgacgg tatcgattag actgtagccc aggaatatgg cagctagatt gtacacattt     4680

agaaggaaaa gttatcttgg tagcagttca tgtagccagt ggatatatag aagcagaagt     4740

aattccagca gagacagggc aagaaacagc atacttcctc ttaaaattag caggaagatg     4800

gccagtaaaa acagtacata cagacaatgg cagcaatttc accagtacta cagttaaggc     4860

cgcctgttgg tgggcgggga tcaagcagga atttggcatt ccctacaatc cccaaagtca     4920

aggagtaata gaatctatga ataaagaatt aaagaaaatt ataggacagg taagagatca     4980

ggctgaacat cttaagacag cagtacaaat ggcagtattc atccacaatt ttaaaagaaa     5040

aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag caacagacat     5100

acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg tttattacag     5160

ggacagcaga gatccagttt ggctgcattg atcacgtgag gctccggtgc ccgtcagtgg     5220

gcagagcgca catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc     5280

ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc     5340

ctttttcccg agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt     5400

tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct     5460

ggcctcttta cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctgcagtac     5520

gtgattcttg atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct     5580

taaggagccc cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc     5640

gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt     5700

taaaattttt gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg     5760

ggccaagatc tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt     5820

gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga     5880

cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc     5940

gccccgccct gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg     6000

ccgcttcccg gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg     6060

gcgggtgagt cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt     6120

gactccactg agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt     6180

acgtcgtctt taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg     6240

gtggagactg aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt     6300

tttgagtttg gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt     6360

ccatttcagg tgtcgtgatc tagaggatcc accatggtga gcaagggcga ggagctgttc     6420

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc     6480

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc     6540

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg     6600

cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg     6660

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc     6720

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc     6780

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac     6840

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc     6900

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc     6960

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc     7020

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg     7080

atcactctcg gcatggacga gctgtacaag taagtcgaca atcaacctct ggattacaaa     7140

atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac     7200

gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc     7260

ttgtataaat cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt     7320

ggcgtggtgt gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc     7380

tgtcagctcc tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc     7440

gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg     7500

gtgttgtcgg ggaagctgac gtcctttcca tggctgctcg cctgtgttgc cacctggatt     7560

ctgcgcggga cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc     7620

cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt     7680

cggatctccc tttgggccgc ctccccgcct ggaattcgag ctcggtacct ttaagaccaa     7740

tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag     7800

ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg tctctctggt     7860

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     7920

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     7980

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt agtagttcat     8040

gtcatcttat tattcagtat ttataacttg caaagaaatg aatatcagag agtgagagga     8100

acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa     8160

ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt     8220

atcatgtctg gctctagcta tcccgcccct aactccgccc atcccgcccc taactccgcc     8280

cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg cagaggccga     8340

ggccgcctcg gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg     8400

gacgtaccca attcgcccta tagtgagtcg tattac                               8436


<210>  53
<211>  8384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53
tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc       60

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat      120

taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt      180

aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt      240

atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat      300

tacgccaagc gcgcaattaa ccctcactaa agggaacaaa agctggagct gcaagcttaa      360

tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt tagcaacatg      420

ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtacgatc      480

gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc actgaattgc      540

cgcattgcag agatattgta tttaagtgcc tagctcgata caataaacgg gtctctctgg      600

ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct      660

caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt      720

aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga      780

acagggacct gaaagcgaaa gggaaaccag agctctctcg acgcaggact cggcttgctg      840

aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta      900

gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta      960

gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac     1020

atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa     1080

catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag     1140

aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag     1200

agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga     1260

ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat     1320

tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc     1380

accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg     1440

ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat gacgctgacg     1500

gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct     1560

attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca     1620

agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc     1680

tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct     1740

ctggaacaga ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca     1800

caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag aatgaacaag     1860

aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata acaaattggc     1920

tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta agaatagttt     1980

ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta tcgtttcaga     2040

cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa gaaggtggag     2100

agagagacag agacagatcc attcgattag tgaacggatc tcgacggtat cgattagact     2160

gtagcccagg aatatggcag ctagattgta cacatttaga aggaaaagtt atcttggtag     2220

cagttcatgt agccagtgga tatatagaag cagaagtaat tccagcagag acagggcaag     2280

aaacagcata cttcctctta aaattagcag gaagatggcc agtaaaaaca gtacatacag     2340

acaatggcag caatttcacc agtactacag ttaaggccgc ctgttggtgg gcggggatca     2400

agcaggaatt tggcattccc tacaatcccc aaagtcaagg agtaatagaa tctatgaata     2460

aagaattaaa gaaaattata ggacaggtaa gagatcaggc tgaacatctt aagacagcag     2520

tacaaatggc agtattcatc cacaatttta aaagaaaagg ggggattggg gggtacagtg     2580

caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa ttacaaaaac     2640

aaattacaaa aattcaaaat tttcgggttt attacaggga cagcagagat ccagtttggc     2700

tgcatacgcg tcgtgaggct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt     2760

ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg     2820

ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga     2880

accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag     2940

aacacaggta agtgccgtgt gtggttcccg cgggcctggc ctctttacgg gttatggccc     3000

ttgcgtgcct tgaattactt ccacctggct gcagtacgtg attcttgatc ccgagcttcg     3060

ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa ggagcccctt cgcctcgtgc     3120

ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt ggcaccttcg     3180

cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat gacctgctgc     3240

gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caagatctgc acactggtat     3300

ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg tcccagcgca catgttcggc     3360

gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc aagctggccg     3420

gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg cggcaaggct     3480

ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc ctgctgcagg     3540

gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac ccacacaaag     3600

gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccactgagt accgggcgcc     3660

gtccaggcac ctcgattagt tctcgtgctt ttggagtacg tcgtctttag gttgggggga     3720

ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag ttaggccagc     3780

ttggcacttg atgtaattct ccttggaatt tgcccttttt gagtttggat cttggttcat     3840

tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcaggtgt cgtgagctag     3900

actagtacca tggacatgcg ggtgcctgca caacttctgg gcctgctgtt gttgtggctg     3960

tctggagccc ggtgtaattg ggtaaatgtt atcagtgatc tcaagaagat agaggatctc     4020

atccagtcca tgcatattga tgccacgctg tacacagaaa gcgatgtgca tcctagctgt     4080

aaggtgacag cgatgaagtg ttttcttttg gagctgcagg taattagtct tgagtccggc     4140

gatgccagca ttcatgatac cgtagaaaac ttgattatcc tggccaacaa ttctctgtcc     4200

tcaaacggaa acgtaaccga gagcggttgt aaagaatgtg aagaactgga agaaaagaac     4260

atcaaggagt ttctgcaatc attcgttcac atcgtacaaa tgttcataaa tacgtcagga     4320

tctggttctg gttccggaag tggatctggt tcagggtccg gtagtggatc tgggtcagga     4380

agtggaagcg gtagtgggtc tggatctaaa caagagcact ttcctgataa cctgttgccg     4440

agctgggcga ttacgcttat cagtgtaaac ggcatctttg taatatgctg tctgacctac     4500

tgcttcgcac caaggtgccg ggagagaagg agaaatgaaa gactgagaag ggagagcgtg     4560

agacctgtgg gatcctaagc tagcgtcggc aatcaacctc tggattacaa aatttgtgaa     4620

agattgactg gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta     4680

atgcctttgt atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa     4740

tcctggttgc tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg     4800

tgcactgtgt ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc     4860

ctttccggga ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc     4920

cttgcccgct gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg     4980

gggaagctga cgtcctttcc atggctgctc gcctgtgttg ccacctggat tctgcgcggg     5040

acgtccttct gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg     5100

ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc     5160

ctttgggccg cctccccgcc tggaattcga gctcggtacc tttaagacca atgacttaca     5220

aggcagctgt agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc     5280

actcccaacg aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga     5340

tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct     5400

tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat     5460

ccctcagacc cttttagtca gtgtggaaaa tctctagcag tagtagttca tgtcatctta     5520

ttattcagta tttataactt gcaaagaaat gaatatcaga gagtgagagg aacttgttta     5580

ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat     5640

ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct     5700

ggctctagct atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg     5760

actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa     5820

gtagtgagga ggcttttttg gaggcctagg cttttgcgtc gagacgtacc caattcgccc     5880

tatagtgagt cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa     5940

aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt     6000

aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa     6060

tggcgcgacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc     6120

gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt     6180

ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc     6240

cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt     6300

agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt     6360

aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt     6420

gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa     6480

aaatttaacg cgaattttaa caaaatatta acgtttacaa tttcccaggt ggcacttttc     6540

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     6600

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     6660

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     6720

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     6780

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     6840

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     6900

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     6960

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     7020

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     7080

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     7140

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     7200

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     7260

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     7320

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     7380

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     7440

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     7500

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     7560

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     7620

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     7680

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     7740

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     7800

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     7860

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     7920

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     7980

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     8040

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     8100

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     8160

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     8220

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     8280

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     8340

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcc                      8384


<210>  54
<211>  9161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54
tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc       60

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat      120

taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt      180

aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt      240

atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat      300

tacgccaagc gcgcaattaa ccctcactaa agggaacaaa agctggagct gcaagcttaa      360

tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt tagcaacatg      420

ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtacgatc      480

gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc actgaattgc      540

cgcattgcag agatattgta tttaagtgcc tagctcgata caataaacgg gtctctctgg      600

ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct      660

caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt      720

aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga      780

acagggacct gaaagcgaaa gggaaaccag agctctctcg acgcaggact cggcttgctg      840

aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta      900

gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta      960

gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac     1020

atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa     1080

catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag     1140

aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag     1200

agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga     1260

ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat     1320

tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc     1380

accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg     1440

ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat gacgctgacg     1500

gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct     1560

attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca     1620

agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc     1680

tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct     1740

ctggaacaga ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca     1800

caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag aatgaacaag     1860

aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata acaaattggc     1920

tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta agaatagttt     1980

ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta tcgtttcaga     2040

cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa gaaggtggag     2100

agagagacag agacagatcc attcgattag tgaacggatc tcgacggtat cgattagact     2160

gtagcccagg aatatggcag ctagattgta cacatttaga aggaaaagtt atcttggtag     2220

cagttcatgt agccagtgga tatatagaag cagaagtaat tccagcagag acagggcaag     2280

aaacagcata cttcctctta aaattagcag gaagatggcc agtaaaaaca gtacatacag     2340

acaatggcag caatttcacc agtactacag ttaaggccgc ctgttggtgg gcggggatca     2400

agcaggaatt tggcattccc tacaatcccc aaagtcaagg agtaatagaa tctatgaata     2460

aagaattaaa gaaaattata ggacaggtaa gagatcaggc tgaacatctt aagacagcag     2520

tacaaatggc agtattcatc cacaatttta aaagaaaagg ggggattggg gggtacagtg     2580

caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa ttacaaaaac     2640

aaattacaaa aattcaaaat tttcgggttt attacaggga cagcagagat ccagtttggc     2700

tgcatacgcg tcgtgaggct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt     2760

ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg     2820

ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga     2880

accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag     2940

aacacaggta agtgccgtgt gtggttcccg cgggcctggc ctctttacgg gttatggccc     3000

ttgcgtgcct tgaattactt ccacctggct gcagtacgtg attcttgatc ccgagcttcg     3060

ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa ggagcccctt cgcctcgtgc     3120

ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt ggcaccttcg     3180

cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat gacctgctgc     3240

gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caagatctgc acactggtat     3300

ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg tcccagcgca catgttcggc     3360

gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc aagctggccg     3420

gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg cggcaaggct     3480

ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc ctgctgcagg     3540

gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac ccacacaaag     3600

gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccactgagt accgggcgcc     3660

gtccaggcac ctcgattagt tctcgtgctt ttggagtacg tcgtctttag gttgggggga     3720

ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag ttaggccagc     3780

ttggcacttg atgtaattct ccttggaatt tgcccttttt gagtttggat cttggttcat     3840

tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcaggtgt cgtgagctag     3900

actagtacca tggacatgcg ggtgcctgca caacttctgg gcctgctgtt gttgtggctg     3960

tctggagccc ggtgtaattg ggtaaatgtt atcagtgatc tcaagaagat agaggatctc     4020

atccagtcca tgcatattga tgccacgctg tacacagaaa gcgatgtgca tcctagctgt     4080

aaggtgacag cgatgaagtg ttttcttttg gagctgcagg taattagtct tgagtccggc     4140

gatgccagca ttcatgatac cgtagaaaac ttgattatcc tggccaacaa ttctctgtcc     4200

tcaaacggaa acgtaaccga gagcggttgt aaagaatgtg aagaactgga agaaaagaac     4260

atcaaggagt ttctgcaatc attcgttcac atcgtacaaa tgttcataaa tacgtcagga     4320

tctggttctg gttccggaag tggatctggt tcagggtccg gtagtggatc tgggtcagga     4380

agtggaagcg gtagtgggtc tggatctaaa caagagcact ttcctgataa cctgttgccg     4440

agctgggcga ttacgcttat cagtgtaaac ggcatctttg taatatgctg tctgacctac     4500

tgcttcgcac caaggtgccg ggagagaagg agaaatgaaa gactgagaag ggagagcgtg     4560

agacctgtgg gatcctccca tcactggggg tacggcaaac acaacggacc tgagcactgg     4620

cataaggact tccccattgc caagggagag cgccagtccc ctgttgacat cgacactcat     4680

acagccaagt atgacccttc cctgaagccc ctgtctgttt cctatgatca agcaacttcc     4740

ctgagaatcc tcaacaatgg tcatgctttc aacgtggagt ttgatgactc tcaggacaaa     4800

gcagtgctca agggaggacc cctggatggc acttacagat tgattcagtt tcactttcac     4860

tggggttcac ttgatggaca aggttcagag catactgtgg ataaaaagaa atatgctgca     4920

gaacttcact tggttcactg gaacaccaaa tatggggatt ttgggaaagc tgtgcagcaa     4980

cctgatggac tggccgttct aggtattttt ttgaaggttg gcagcgctaa accgggccat     5040

cagaaagttg ttgatgtgct ggattccatt aaaacaaagg gcaagagtgc tgacttcact     5100

aacttcgatc ctcgtggcct ccttcctgaa tccctggatt actggaccta cccaggctca     5160

ctgaccaccc ctcctcttct ggaatgtgtg acctggattg tgctcaagga acccatcagc     5220

gtcagcagcg agcaggtgtt gaaattccgt aaacttaact tcaatgggga gggtgaaccc     5280

gaagaactga tggtggacaa ctggcgccca gctcagccac tgaagaacag gcaaatcaaa     5340

gcttccttca aataagctag cgtcgacaat caacctctgg attacaaaat ttgtgaaaga     5400

ttgactggta ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg     5460

cctttgtatc atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc     5520

tggttgctgt ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc     5580

actgtgtttg ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt     5640

tccgggactt tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt     5700

gcccgctgct ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg     5760

aagctgacgt cctttccatg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg     5820

tccttctgct acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg     5880

ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt     5940

tgggccgcct ccccgcctgg aattcgagct cggtaccttt aagaccaatg acttacaagg     6000

cagctgtaga tcttagccac tttttaaaag aaaagggggg actggaaggg ctaattcact     6060

cccaacgaag acaagatctg ctttttgctt gtactgggtc tctctggtta gaccagatct     6120

gagcctggga gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc     6180

cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc     6240

tcagaccctt ttagtcagtg tggaaaatct ctagcagtag tagttcatgt catcttatta     6300

ttcagtattt ataacttgca aagaaatgaa tatcagagag tgagaggaac ttgtttattg     6360

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     6420

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctggc     6480

tctagctatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     6540

aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta     6600

gtgaggaggc ttttttggag gcctaggctt ttgcgtcgag acgtacccaa ttcgccctat     6660

agtgagtcgt attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac     6720

cctggcgtta cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat     6780

agcgaagagg cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg     6840

cgcgacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg     6900

accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc     6960

gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga     7020

tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt     7080

gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat     7140

agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat     7200

ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa     7260

tttaacgcga attttaacaa aatattaacg tttacaattt cccaggtggc acttttcggg     7320

gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc     7380

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta     7440

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg     7500

ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg     7560

gttacatcga actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac     7620

gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg     7680

acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt     7740

actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg     7800

ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac     7860

cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt     7920

gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag     7980

caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc     8040

aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc     8100

ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta     8160

tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg     8220

ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga     8280

ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac     8340

ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa     8400

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat     8460

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc     8520

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg     8580

gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc     8640

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg     8700

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg     8760

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa     8820

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg     8880

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga     8940

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct     9000

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca     9060

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc     9120

ctgcgttatc ccctgattct gtggataacc gtattaccgc c                         9161


<210>  55
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His 
1               5                   10                  15      


Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile 
            20                  25                  30          


Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val 
        35                  40                  45              


Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala 
    50                  55                  60                  


Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly 
65                  70                  75                  80  


Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp 
                85                  90                  95      


Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys 
            100                 105                 110         


Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
        115                 120                 125             


Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile 
    130                 135                 140                 


Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val Asp 
145                 150                 155                 160 


Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn 
                165                 170                 175     


Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr 
            180                 185                 190         


Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
        195                 200                 205             


Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe 
    210                 215                 220                 


Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val 
225                 230                 235                 240 


Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala 
                245                 250                 255     


Ser Phe Lys 
            


<210>  56
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Asn Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  57
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His 
1               5                   10                  15      


Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile 
            20                  25                  30          


Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val 
        35                  40                  45              


Ser Tyr Asp Gln Ala Thr Asn Leu Arg Ile Leu Asn Asn Gly His Ala 
    50                  55                  60                  


Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly 
65                  70                  75                  80  


Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp 
                85                  90                  95      


Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys 
            100                 105                 110         


Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
        115                 120                 125             


Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile 
    130                 135                 140                 


Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val Asp 
145                 150                 155                 160 


Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn 
                165                 170                 175     


Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr 
            180                 185                 190         


Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
        195                 200                 205             


Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe 
    210                 215                 220                 


Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val 
225                 230                 235                 240 


Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala 
                245                 250                 255     


Ser Phe Lys 
            


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  59
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


<210>  60
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Met Gly Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg 
1               5                   10                  15      


Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met 
            20                  25                  30          


Ala 
    


