                         SEQUENCE LISTING

<110>  Arbor Biotechnologies
 
<120>  Compositions Comprising a Nuclease and Uses Thereof

<130>  381834-7004WO1(00014)

<150>  63/140,608
<151>  2021-01-22

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease

<400>  1

Met Ala Phe Gln Ser Lys Arg Arg Ile Val Gly Asn Phe Val Lys Glu 
1               5                   10                  15      


Gln Cys Leu Lys Ala Val Asp Gly Lys Val Ile Leu Thr Asp Gln Glu 
            20                  25                  30          


Lys Arg Glu Leu Ile Lys Arg Tyr Glu Leu His Leu Glu Pro His Lys 
        35                  40                  45              


Trp Leu Leu Arg Leu Phe Leu Ser Gly Tyr Glu Gly Arg Asp Asp Gly 
    50                  55                  60                  


Phe Tyr Glu Glu Leu Gly Asn Thr Asn Leu Asp Lys Glu Lys Phe Phe 
65                  70                  75                  80  


Glu Val Thr Ala Gly Leu Arg Asp Ala Leu Leu Arg Gln Ser Gly Ser 
                85                  90                  95      


Ser Arg Ala Leu Lys Ser Ser Met Leu Gly Lys Cys Pro Pro Ser Ala 
            100                 105                 110         


Ala Val Gly Lys Ala Ala Lys His Ile Gln Thr Leu Arg Asp Ala Gly 
        115                 120                 125             


Ile Leu Pro Phe Lys Thr Gly Leu Thr Ser Gly Glu Asp Tyr Asn Val 
    130                 135                 140                 


Leu Gln Gln Ala Val Gln Gln Leu Arg Ser Trp Val Ala Cys Asp His 
145                 150                 155                 160 


Arg Thr Arg Glu Ala Tyr Ala Glu Gln Gln Glu Lys Thr Ser Gln Ala 
                165                 170                 175     


Glu Glu Ala Ala Lys Lys Ala Ala Asn Glu Val Lys Pro Glu Asp Ala 
            180                 185                 190         


Lys Ser Leu Glu Arg His Glu Arg Val Leu Thr Lys Leu Arg Lys Gln 
        195                 200                 205             


Glu Arg Arg Leu Glu Arg Met Lys Ser His Ala Gln Phe Ser Leu Asp 
    210                 215                 220                 


Glu Met Asp Cys Thr Gly Tyr Ser Leu Cys Met Gly Ala Asn Tyr Leu 
225                 230                 235                 240 


Lys Asp Tyr Cys Leu Glu Lys Glu Gly Arg Gly Leu Arg Leu Thr Leu 
                245                 250                 255     


Lys Asn Ser Thr Met Ala Gly Ser Tyr Tyr Val Ser Val Gly Asp Gly 
            260                 265                 270         


Gln His Ala Gly Met Lys Asn Pro Gly Thr Pro Ala Gly Gly Ser Pro 
        275                 280                 285             


Glu Lys Gly Arg Arg Arg Asn Ile Leu Phe Asp Phe Thr Val Glu Lys 
    290                 295                 300                 


Cys Gly Asp Asn Tyr Leu Phe Arg Tyr Asp Glu Asn Gly Lys Arg Pro 
305                 310                 315                 320 


Arg Ala Gly Val Val Lys Glu Pro Arg Phe Cys Trp Arg Arg Lys Gly 
                325                 330                 335     


Asn Ser Val Glu Leu Tyr Leu Ala Met Pro Ile Asn Ile Glu Asn Ser 
            340                 345                 350         


Met Arg Asn Ile Phe Val Gly Lys Gln Lys Ser Gly Lys His Ser Ala 
        355                 360                 365             


Phe Thr Arg Gln Trp Pro Lys Glu Val Glu Gly Leu Asp Glu Leu Arg 
    370                 375                 380                 


Asp Ala Val Val Leu Gly Val Asp Ile Gly Ile Asn Arg Ala Ala Phe 
385                 390                 395                 400 


Cys Ala Ala Leu Lys Thr Ser Arg Phe Glu Asn Gly Leu Pro Ala Asp 
                405                 410                 415     


Val Gln Val Met Asp Thr Thr Cys Asp Ala Leu Thr Glu Lys Gly Gln 
            420                 425                 430         


Glu Tyr Arg Gln Leu Arg Lys Asp Ala Thr Cys Leu Ala Trp Leu Ile 
        435                 440                 445             


Arg Thr Thr Arg Arg Phe Lys Ala Asp Pro Gly Asn Lys His Asn Gln 
    450                 455                 460                 


Ile Lys Glu Lys Asp Val Glu Arg Phe Asp Ser Ala Asp Gly Ala Tyr 
465                 470                 475                 480 


Arg Arg Tyr Met Asp Ala Ile Ala Glu Met Pro Ser Asp Pro Leu Gln 
                485                 490                 495     


Val Trp Glu Ala Ala Arg Ile Thr Gly Tyr Gly Glu Trp Ala Lys Glu 
            500                 505                 510         


Ile Phe Ala Arg Phe Asn His Tyr Lys His Glu His Ala Cys Cys Ala 
        515                 520                 525             


Val Ser Leu Ser Leu Ser Asp Arg Leu Val Trp Cys Arg Leu Ile Asp 
    530                 535                 540                 


Arg Ile Leu Ser Leu Lys Lys Cys Leu His Phe Gly Gly Tyr Glu Ser 
545                 550                 555                 560 


Lys His Arg Lys Gly Phe Cys Lys Ser Leu Tyr Arg Leu Arg His Asn 
                565                 570                 575     


Ala Arg Asn Asp Val Arg Lys Lys Leu Ala Arg Phe Ile Val Asp Ala 
            580                 585                 590         


Ala Val Asp Ala Gly Ala Ser Val Ile Ala Met Glu Lys Leu Pro Ser 
        595                 600                 605             


Ser Gly Gly Lys Gln Ser Lys Asp Asp Asn Arg Ile Trp Asp Leu Met 
    610                 615                 620                 


Ala Pro Asn Thr Leu Ala Thr Thr Val Cys Leu Met Ala Lys Val Glu 
625                 630                 635                 640 


Gly Ile Gly Phe Val Gln Val Asp Pro Glu Phe Thr Ser Gln Trp Val 
                645                 650                 655     


Phe Glu Gln Arg Val Ile Gly Asp Arg Glu Gly Arg Ile Val Ser Cys 
            660                 665                 670         


Leu Asp Ala Glu Gly Val Arg Arg Asp Tyr Asp Ala Asp Glu Asn Ala 
        675                 680                 685             


Ala Lys Asn Ile Ala Trp Leu Ala Leu Thr Arg Glu Ala Glu Pro Phe 
    690                 695                 700                 


Cys Met Ala Phe Glu Lys Arg Asn Gly Val Val Glu Pro Lys Gly Leu 
705                 710                 715                 720 


Arg Phe Asp Ile Pro Glu Glu Pro Thr Arg Glu Gln Asp Glu Ser Asp 
                725                 730                 735     


Gln Asp Phe Lys Lys Arg Leu Glu Glu Arg Asp Lys Leu Ile Glu Arg 
            740                 745                 750         


Leu Gln Ala Lys Ala Asp Arg Met Gln Ala Ile Val Gln Arg Leu Phe 
        755                 760                 765             


Gly Asp Arg Arg Pro Trp Asp Ala Phe Ala Asp Arg Ile Pro Glu Gly 
    770                 775                 780                 


Lys Ser Lys Arg Leu Phe Arg His Arg Asp Gly Leu Val Leu Asn Lys 
785                 790                 795                 800 


Pro Phe Lys Gly Leu Cys Gly Ser Glu Asn Ser Glu Gln Lys Ala Ser 
                805                 810                 815     


Ala Arg Asn Ser Arg 
            820     


<210>  2
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease

<400>  2

Met Ala Phe Gln Ser Lys Arg Arg Ile Val Gly Asn Phe Val Lys Glu 
1               5                   10                  15      


Gln Cys Leu Lys Ala Val Asp Gly Lys Val Ile Leu Thr Asp Gln Glu 
            20                  25                  30          


Lys Arg Glu Leu Ile Lys Arg Tyr Glu Leu His Leu Glu Pro His Lys 
        35                  40                  45              


Trp Leu Leu Arg Leu Phe Leu Ser Gly Tyr Glu Gly Arg Asp Asp Gly 
    50                  55                  60                  


Phe Tyr Glu Glu Leu Gly Asn Thr Asn Leu Asp Lys Glu Lys Phe Phe 
65                  70                  75                  80  


Glu Val Thr Ala Gly Leu Arg Asp Ala Leu Leu Arg Gln Ser Gly Ser 
                85                  90                  95      


Ser Arg Ala Leu Lys Ser Ser Met Leu Gly Lys Cys Pro Pro Ser Ala 
            100                 105                 110         


Ala Val Gly Lys Ala Ala Lys His Ile Gln Thr Leu Arg Asp Ala Gly 
        115                 120                 125             


Ile Leu Pro Phe Lys Thr Gly Leu Thr Ser Gly Glu Asp Tyr Asn Val 
    130                 135                 140                 


Leu Gln Gln Ala Val Gln Gln Leu Arg Ser Trp Val Ala Cys Asp His 
145                 150                 155                 160 


Arg Thr Arg Glu Ala Tyr Ala Glu Gln Gln Glu Lys Thr Ser Gln Ala 
                165                 170                 175     


Glu Glu Ala Ala Lys Lys Ala Ala Asn Glu Val Lys Pro Glu Asp Ala 
            180                 185                 190         


Lys Ser Leu Glu Arg His Glu Arg Val Leu Thr Lys Leu Arg Lys Gln 
        195                 200                 205             


Glu Arg Arg Leu Glu Arg Met Lys Ser His Ala Gln Phe Ser Leu Asp 
    210                 215                 220                 


Glu Met Asp Cys Thr Gly Tyr Ser Leu Cys Met Gly Ala Asn Tyr Leu 
225                 230                 235                 240 


Lys Asp Tyr Cys Leu Glu Lys Glu Gly Arg Gly Leu Arg Leu Thr Leu 
                245                 250                 255     


Lys Asn Ser Thr Met Ala Gly Ser Tyr Tyr Val Ser Val Gly Asp Gly 
            260                 265                 270         


Gln His Ala Gly Met Lys Asn Pro Gly Thr Pro Ala Gly Gly Ser Pro 
        275                 280                 285             


Glu Lys Gly Arg Arg Arg Asn Ile Leu Phe Asp Phe Thr Val Glu Lys 
    290                 295                 300                 


Cys Gly Asp Asn Tyr Leu Phe Arg Tyr Asp Glu Asn Gly Lys Arg Pro 
305                 310                 315                 320 


Arg Ala Gly Val Val Lys Glu Pro Arg Phe Cys Trp Arg Arg Lys Gly 
                325                 330                 335     


Asn Ser Val Glu Leu Tyr Leu Ala Met Pro Ile Asn Ile Glu Asn Ser 
            340                 345                 350         


Met Arg Asn Ile Phe Val Gly Lys Gln Lys Ser Gly Lys His Ser Ala 
        355                 360                 365             


Phe Thr Arg Gln Trp Pro Lys Glu Val Glu Gly Leu Asp Glu Leu Arg 
    370                 375                 380                 


Asp Ala Val Val Leu Gly Val Asp Ile Gly Ile Asn Arg Ala Ala Phe 
385                 390                 395                 400 


Cys Ala Ala Leu Lys Thr Ser Arg Phe Glu Asn Gly Leu Pro Ala Asp 
                405                 410                 415     


Val Gln Val Met Asp Thr Thr Cys Asp Ala Leu Thr Glu Lys Gly Gln 
            420                 425                 430         


Glu Tyr Arg Gln Leu Arg Lys Asp Ala Thr Cys Leu Ala Trp Leu Ile 
        435                 440                 445             


Arg Thr Thr Arg Arg Phe Lys Ala Asp Pro Gly Asn Lys His Asn Gln 
    450                 455                 460                 


Ile Lys Glu Lys Asp Val Glu Arg Phe Asp Ser Ala Asp Gly Ala Tyr 
465                 470                 475                 480 


Arg Arg Tyr Met Asp Ala Ile Ala Glu Met Pro Ser Asp Pro Leu Gln 
                485                 490                 495     


Val Trp Glu Ala Ala Arg Ile Thr Gly Tyr Gly Glu Trp Ala Lys Glu 
            500                 505                 510         


Ile Phe Ala Arg Phe Asn His Tyr Lys His Glu His Ala Cys Cys Ala 
        515                 520                 525             


Val Ser Leu Ser Leu Ser Asp Arg Leu Val Trp Cys Arg Leu Ile Asp 
    530                 535                 540                 


Arg Ile Leu Ser Leu Lys Lys Cys Leu His Phe Gly Gly Tyr Glu Ser 
545                 550                 555                 560 


Lys His Arg Lys Gly Phe Cys Lys Ser Leu Tyr Arg Leu Arg His Asn 
                565                 570                 575     


Ala Arg Asn Asp Val Arg Lys Lys Leu Ala Arg Phe Ile Val Asp Ala 
            580                 585                 590         


Ala Val Asp Ala Gly Ala Ser Val Ile Ala Met Glu Lys Leu Pro Ser 
        595                 600                 605             


Ser Gly Gly Lys Gln Ser Lys Asp Asp Asn Arg Ile Trp Asp Leu Met 
    610                 615                 620                 


Ala Pro Asn Thr Leu Ala Thr Thr Val Cys Leu Met Ala Lys Val Glu 
625                 630                 635                 640 


Gly Ile Gly Phe Val Gln Val Asp Pro Glu Phe Thr Ser Gln Trp Val 
                645                 650                 655     


Phe Glu Gln Arg Val Ile Gly Asp Arg Glu Gly Arg Ile Val Ser Cys 
            660                 665                 670         


Leu Asp Ala Glu Gly Val Arg Arg Asp Tyr Asp Ala Asp Glu Asn Ala 
        675                 680                 685             


Ala Lys Asn Ile Ala Trp Leu Ala Leu Thr Arg Glu Ala Glu Pro Phe 
    690                 695                 700                 


Cys Met Ala Phe Glu Lys Arg Asn Gly Val Val Glu Pro Lys Gly Leu 
705                 710                 715                 720 


Arg Phe Asp Ile Pro Glu Glu Pro Thr Arg Glu Gln Asp Glu Ser Asp 
                725                 730                 735     


Gln Asp Phe Lys Lys Arg Leu Glu Glu Arg Asp Lys Leu Ile Glu Arg 
            740                 745                 750         


Leu Gln Ala Lys Ala Asp Arg Met Gln Ala Ile Val Gln Arg Leu Phe 
        755                 760                 765             


Gly Asp Arg Arg Pro Trp Asp Ala Phe Ala Asp Arg Ile Pro Glu Gly 
    770                 775                 780                 


Lys Ser Lys Arg Leu Phe Arg His Arg Asp Gly Leu Val Leu Asn Lys 
785                 790                 795                 800 


Pro Phe Lys Gly Leu Cys Gly Ser Glu Asn Ser Gly Gln Lys Ala Ser 
                805                 810                 815     


Ala Arg Asn Ser Arg 
            820     


<210>  3
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease

<400>  3

Met Gly Arg Phe Gly Lys Lys Lys Ile Ala Val Asn Gly Tyr Val Glu 
1               5                   10                  15      


Gln Asp Cys Ile Lys Thr Ile Ser Ala Lys Cys Leu Leu Thr Arg Ala 
            20                  25                  30          


Gln Ile Asp Glu Leu Arg Ala Lys Tyr Asp Ala Val Leu Asp Thr Met 
        35                  40                  45              


Arg Pro Leu Ile Arg Leu Ile Leu Ala Gly Tyr Glu Gly Arg Asp Asp 
    50                  55                  60                  


Gly Ile Tyr Glu Glu Ile Ala Pro Glu Met Ser Lys Lys Lys Phe Phe 
65                  70                  75                  80  


Glu Ala Ala Thr Glu Trp Arg Glu Ser Ile Val Lys Asn Ala Ser Pro 
                85                  90                  95      


Arg Ala Met Lys Ala Ser Val Phe Gly Asp Lys Glu Pro Cys Lys Ser 
            100                 105                 110         


Thr Gly Gly Ala Arg Ala Val Ile Gly Lys Leu Arg Lys Ser Gly Val 
        115                 120                 125             


Phe Pro Ile Glu Thr Gly Leu Ser Gly Gly Asp Glu Tyr Asn Leu Ile 
    130                 135                 140                 


Glu Gln Ala Ile Glu Tyr Ala Lys Ser Trp Leu Lys Ser Asp Glu Ala 
145                 150                 155                 160 


Thr Arg Glu Ala Tyr Ala Asp Gln Gln Lys Asp Ile Lys Arg Leu Ile 
                165                 170                 175     


Gly Glu Ala Lys Lys Leu Ala Leu Lys Ile Glu Lys Ala Glu Lys Lys 
            180                 185                 190         


Leu Glu Ala Thr Asn Pro Gln Thr Lys Ser Trp Lys Lys Thr Thr Glu 
        195                 200                 205             


Ile Ile Lys Lys Ser Lys Arg Glu Phe Gly Ser Val Thr Thr Lys Thr 
    210                 215                 220                 


Glu Lys Ala Glu Lys Arg Phe Glu Arg Met Lys Pro Phe Ser Lys Leu 
225                 230                 235                 240 


Glu Leu Gln Asn Met Asp Cys Thr Lys Tyr Ser Thr Tyr Leu Gly Thr 
                245                 250                 255     


Asn Tyr Ser Pro Phe Lys Leu Lys Lys Glu Gly Asp Leu Leu Gln Ile 
            260                 265                 270         


Thr Val Thr Ser Ser Val Met Lys Gly Thr Tyr Leu Ala Ser Tyr Gly 
        275                 280                 285             


Asp Gly Gln Tyr Gly Ser Arg Arg Asn Asn Gly Gln Ser Arg Arg Asp 
    290                 295                 300                 


Asp Phe Val Pro Asn Met Asn Gln Lys Arg Arg Arg Asn Leu Met Phe 
305                 310                 315                 320 


Asp Cys Thr Val Glu Pro Phe Gly Asp Gly Ser Leu Leu Arg Tyr Glu 
                325                 330                 335     


Glu Asn Gly Leu Arg Pro Arg Val Ala Glu Leu Lys Glu Pro Arg Leu 
            340                 345                 350         


Cys Trp Arg Arg Arg Asn Gly Asn Tyr Glu Leu Tyr Leu Met Met Pro 
        355                 360                 365             


Val Lys Met His Val Lys Ser Pro Glu Met Phe Ala Gly Asp His Leu 
    370                 375                 380                 


Ala Phe Ser Arg Tyr Trp Pro Lys Glu Val Glu Gly Leu Asp Ser Asp 
385                 390                 395                 400 


Thr Lys Ile Thr Ala Leu Gly Val Asp Val Gly Ile Ile Arg Ser Ala 
                405                 410                 415     


Tyr Cys Val Ala Val Thr Ala Glu Arg Phe Val Asp Gly Leu Pro Thr 
            420                 425                 430         


Glu Met Thr Val Gly Lys Ala Ser Phe Asp Ala Gln Thr Glu Lys Gly 
        435                 440                 445             


Arg Glu Tyr Phe Glu Leu Gly Arg Arg Ala Thr Met Leu Gly Trp Leu 
    450                 455                 460                 


Ile Lys Thr Thr Arg Arg Tyr Lys Lys Asp Pro Lys Asn Glu His Asn 
465                 470                 475                 480 


Gln Ile Lys Glu Ser Asp Val Ala Ala Phe Asp Gly Ser Pro Gly Ala 
                485                 490                 495     


Phe Glu His Tyr Ile Leu Ala Val Asp Glu Met Ser Asp Asp Pro Leu 
            500                 505                 510         


Asp Val Trp Gly His Ala Asn Ile Thr Gly Tyr Gly Lys Trp Thr Lys 
        515                 520                 525             


Gln Ile Phe Lys Glu Phe Asn Gln Leu Lys Arg Glu Arg Ala Glu Gly 
    530                 535                 540                 


Gln Val Glu Pro Asn Met Thr Asp Asp Leu Thr Trp Cys Ser Leu Ile 
545                 550                 555                 560 


Asp Tyr Ile Ile Ser Leu Lys Lys Thr Leu His Phe Gly Gly Tyr Glu 
                565                 570                 575     


Thr Lys Glu Arg Glu Ser Phe Cys Pro Ala Leu Tyr Asn Glu Arg Ala 
            580                 585                 590         


Asn Cys Arg Asp Val Val Arg Lys Arg Leu Ala Arg Tyr Val Val Glu 
        595                 600                 605             


Arg Ala Ile Ala Ala Glu Ala Gln Val Ile Ser Val Glu Asn Leu Ser 
    610                 615                 620                 


Lys Cys Arg Arg Asp Asp Lys Arg Lys Asn Arg Val Trp Asp Leu Met 
625                 630                 635                 640 


Ser Gln Gln Ser Trp Ile Gly Val Leu Thr Asn Met Ala Arg Met Glu 
                645                 650                 655     


Asn Ile Ala Val Val Ser Val Asn Pro Asp Leu Thr Ser Gln Trp Val 
            660                 665                 670         


Glu Gln Cys Gly Ala Ile Gly Asp Arg Lys Ala Arg Thr Ile Ala Cys 
        675                 680                 685             


Arg Asp Val Asn Gly Lys Phe Val Ser Leu Asp Ala Asp Leu Asn Ala 
    690                 695                 700                 


Ala Tyr Asn Ile Ala Ser Arg Ala Leu Thr Arg His Ala Glu Pro Phe 
705                 710                 715                 720 


Ser Ile Thr Phe Lys Lys Lys Asp Gly Ile Leu Glu Gln Lys Asp Val 
                725                 730                 735     


Cys Phe Asp Pro Gly Val Ile Pro Val Leu Glu Lys Asn Glu Asn Glu 
            740                 745                 750         


Glu Lys Phe Arg Glu Arg Val Glu Lys Tyr Glu Lys Ser Leu Val Ile 
        755                 760                 765             


Lys Gln Glu Arg Ala Val Arg Trp Arg Ala Ile Leu Gln His Leu Phe 
    770                 775                 780                 


Gly Asn Glu Arg Pro Trp Asp Glu Phe Thr Asp Glu Val Lys Glu Gly 
785                 790                 795                 800 


Arg His Val Ser Leu Tyr Arg His His Gly Lys Leu Val Arg Thr Lys 
                805                 810                 815     


Gln Tyr Ala Gly Leu Val Lys Glu Ala Asn Asn Glu Leu Val Pro Val 
            820                 825                 830         


Cys Ala Val Ala Arg 
        835         


<210>  4
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease

<400>  4

Met Ala Phe Gln Ser Lys Arg Arg Ile Val Gly Asn Leu Val Lys Glu 
1               5                   10                  15      


Gln Cys Leu Lys Ala Val Asp Gly Lys Val Ile Leu Thr Asp Gln Glu 
            20                  25                  30          


Lys Arg Glu Leu Ile Lys Arg Tyr Glu Leu His Leu Glu Pro Tyr Lys 
        35                  40                  45              


Trp Leu Leu Arg Leu Phe Leu Ser Gly Tyr Glu Gly Arg Asp Asp Gly 
    50                  55                  60                  


Phe Tyr Glu Glu Leu Gly Asn Thr Asn Leu Asp Lys Glu Lys Phe Phe 
65                  70                  75                  80  


Glu Val Thr Ala Gly Leu Arg Asp Ala Leu Leu Arg Gln Ser Gly Ser 
                85                  90                  95      


Ser Arg Ala Leu Lys Ser Ser Met Leu Gly Lys Cys Pro Pro Ser Ala 
            100                 105                 110         


Ala Val Gly Lys Ala Ala Lys His Ile Gln Ala Leu Arg Asp Ala Gly 
        115                 120                 125             


Ile Leu Pro Phe Lys Thr Gly Leu Thr Ser Gly Glu Asp Tyr Asn Val 
    130                 135                 140                 


Leu Gln Gln Ala Val Gln Gln Leu Arg Ser Trp Val Ala Cys Asp His 
145                 150                 155                 160 


Arg Thr Arg Glu Ala Tyr Ala Glu Gln Gln Glu Lys Thr Ser Gln Ala 
                165                 170                 175     


Glu Glu Ala Ala Lys Lys Ala Val Asn Glu Val Lys Pro Glu Asp Ala 
            180                 185                 190         


Lys Ser Leu Glu Arg His Glu Arg Ala Leu Thr Lys Leu Arg Lys Gln 
        195                 200                 205             


Glu Arg Arg Leu Glu Arg Met Arg Ser His Ala Gln Phe Ser Leu Asp 
    210                 215                 220                 


Glu Met Asp Cys Thr Gly Tyr Ser Leu Cys Met Gly Ala Asn Tyr Leu 
225                 230                 235                 240 


Lys Asp Tyr Cys Leu Glu Lys Glu Gly Arg Gly Leu Arg Leu Thr Leu 
                245                 250                 255     


Lys Asn Ser Thr Met Ala Gly Ser Tyr Tyr Val Ser Val Gly Asp Gly 
            260                 265                 270         


Gln His Ala Gly Met Lys Asn Pro Gly Thr Pro Ala Gly Gly Ser Pro 
        275                 280                 285             


Glu Lys Gly Arg Arg Arg Asn Ile Leu Phe Asp Phe Ala Val Glu Lys 
    290                 295                 300                 


Cys Gly Asp Asn Tyr Leu Phe Arg Tyr Asp Glu Asn Gly Lys Arg Pro 
305                 310                 315                 320 


Arg Ala Gly Val Val Lys Glu Pro Arg Phe Cys Trp Arg Arg Lys Gly 
                325                 330                 335     


Asn Ser Val Glu Leu Tyr Leu Ala Met Pro Ile Asn Ile Glu Asn Ser 
            340                 345                 350         


Met Arg Asn Ile Phe Val Gly Lys Gln Lys Ser Gly Lys His Ser Ala 
        355                 360                 365             


Phe Thr Arg Gln Trp Pro Lys Glu Val Glu Gly Leu Asp Glu Leu Arg 
    370                 375                 380                 


Asp Ala Val Val Leu Gly Val Asp Ile Gly Ile Asn Arg Ala Ala Phe 
385                 390                 395                 400 


Cys Ala Ala Leu Lys Thr Ser Arg Phe Glu Asn Gly Leu Pro Ala Asp 
                405                 410                 415     


Val Gln Val Met Asp Thr Thr Cys Asp Ala Leu Thr Glu Lys Gly Gln 
            420                 425                 430         


Glu Tyr Arg Gln Leu Arg Lys Asp Ala Thr Cys Leu Ala Trp Leu Ile 
        435                 440                 445             


Arg Thr Thr Arg Arg Phe Lys Ala Asp Pro Gly Asn Lys His Asn Gln 
    450                 455                 460                 


Ile Lys Glu Lys Asp Val Glu Arg Phe Asp Ser Ala Asp Gly Ala Tyr 
465                 470                 475                 480 


Arg Arg Tyr Met Asp Ala Ile Ala Glu Met Pro Ser Asp Pro Leu Gln 
                485                 490                 495     


Val Trp Glu Ala Ala Arg Ile Thr Gly Tyr Gly Glu Trp Ala Lys Glu 
            500                 505                 510         


Ile Phe Ala Arg Phe Asn His Tyr Lys His Glu His Ala Cys Cys Thr 
        515                 520                 525             


Val Ser Leu Ser Leu Ser Asp Arg Leu Val Trp Cys Arg Leu Ile Asp 
    530                 535                 540                 


Arg Ile Leu Ser Leu Lys Lys Cys Leu His Phe Gly Gly Tyr Glu Ser 
545                 550                 555                 560 


Lys His Arg Lys Gly Phe Cys Lys Ser Leu Tyr Arg Leu Arg His Asn 
                565                 570                 575     


Ala Arg Asn Asp Val Arg Lys Lys Leu Ala Arg Phe Val Val Asp Ala 
            580                 585                 590         


Ala Val Asp Ala Gly Ala Ser Val Ile Ala Met Glu Lys Leu Pro Ser 
        595                 600                 605             


Ser Gly Gly Lys Gln Ser Arg Asp Asp Asn Arg Ile Trp Asp Leu Met 
    610                 615                 620                 


Ala Pro Asn Thr Leu Ala Thr Thr Val Cys Leu Met Ala Lys Val Glu 
625                 630                 635                 640 


Gly Ile Gly Phe Val Gln Val Asp Pro Glu Phe Thr Ser Gln Trp Val 
                645                 650                 655     


Phe Glu Gln Arg Val Ile Gly Asp Arg Glu Gly Arg Ile Val Ser Cys 
            660                 665                 670         


Leu Asp Ala Glu Gly Val Arg Arg Asp Tyr Asp Ala Asp Glu Asn Ala 
        675                 680                 685             


Ala Lys Asn Ile Ala Trp Leu Ala Leu Thr Arg Glu Ala Glu Pro Phe 
    690                 695                 700                 


Cys Met Ala Phe Glu Lys Arg Asn Gly Val Val Glu Pro Lys Gly Phe 
705                 710                 715                 720 


Arg Phe Asp Ile Pro Glu Glu Pro Thr Arg Glu Gln Asp Glu Ser Asn 
                725                 730                 735     


Gln Asp Phe Lys Lys Arg Leu Glu Glu Arg Asp Lys Leu Ile Glu Arg 
            740                 745                 750         


Leu Gln Ala Lys Ser Asp Arg Met Arg Ala Ile Val Arg Arg Leu Phe 
        755                 760                 765             


Gly Asp Arg Arg Pro Trp Asp Ala Phe Ala Asp Arg Ile Pro Glu Gly 
    770                 775                 780                 


Lys Ser Lys Arg Leu Phe Arg His Arg Asp Gly Leu Val Leu Asn Lys 
785                 790                 795                 800 


Pro Phe Lys Gly Leu Cys Gly Ser Glu Asn Ser Glu Gln Lys Ala Ser 
                805                 810                 815     


Ala Arg Asn Ser Arg 
            820     


<210>  5
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Direct Repeat

<400>  5
guguaggccu ccucugaaug ggguggcuaa ugacac                                 36


<210>  6
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Direct Repeat

<400>  6
gugucauuag ccaccccauu cagaggaggc cuacac                                 36


<210>  7
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Direct Repeat

<400>  7
cauucagaac ggaucaacac                                                   20


<210>  8
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Direct Repeat

<400>  8
guguugaucc guucugaaug                                                   20


<210>  9
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFA target locus

<400>  9
ggtaaaggta ttgggaggtt agagt                                             25


<210>  10
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  10
guguaggccu ccucugaaug ggguggcuaa ugacacggua aagguauugg gagguuagag       60

u                                                                       61


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is F or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is S or A

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is F or I

<400>  11

Leu Xaa Arg Leu Xaa Leu Xaa Gly Tyr Glu Gly Arg Asp Asp Gly Xaa 
1               5                   10                  15      


Tyr Glu Glu 
            


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is E or D

<400>  12

Thr Arg Glu Ala Tyr Ala Xaa Gln Gln 
1               5                   


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is F or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D or E

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is K or L

<400>  13

Leu Xaa Arg Tyr Xaa Glu Asn Gly Xaa Arg Pro Arg 
1               5                   10          


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease


<220>
<221>  MISC_FEATURE
<223>  Xaa is F or L

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Lys Glu Pro Arg Xaa Cys Trp Arg Arg 
1               5                   


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is K or D

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is S or L

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is T or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Q or Y

<400>  15

Gly Xaa His Xaa Ala Phe Xaa Arg Xaa Trp Pro Lys Glu Val Glu Gly 
1               5                   10                  15      


Leu Asp 
        


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is G or K

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is K or E

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is K or S

<400>  16

Asp Pro Xaa Asn Xaa His Asn Gln Ile Lys Glu Xaa Asp Val 
1               5                   10                  


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is C or T

<400>  17

Ser Leu Lys Lys Xaa Leu His Phe Gly Gly Tyr Glu 
1               5                   10          


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclease


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is E or H

<400>  18

Ala Leu Thr Arg Xaa Ala Glu Pro Phe 
1               5                   


<210>  19
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIG. 1A Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is space

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is F, Y, or L

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa is H, M, or Y

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  Xaa is T, K, or A

<220>
<221>  MISC_FEATURE
<222>  (196)..(211)
<223>  Xaa is space

<220>
<221>  MISC_FEATURE
<222>  (218)..(218)
<223>  Xaa is space, E, or A

<220>
<221>  MISC_FEATURE
<222>  (219)..(221)
<223>  Xaa is space

<220>
<221>  MISC_FEATURE
<222>  (308)..(311)
<223>  Xaa is space

<220>
<221>  MISC_FEATURE
<222>  (553)..(553)
<223>  Xaa is A, Q, or T

<220>
<221>  MISC_FEATURE
<222>  (614)..(614)
<223>  Xaa is I or V

<220>
<221>  MISC_FEATURE
<222>  (745)..(745)
<223>  Xaa is L, V, or F

<220>
<221>  MISC_FEATURE
<222>  (761)..(761)
<223>  Xaa is D, E, or N

<220>
<221>  MISC_FEATURE
<222>  (786)..(786)
<223>  Xaa is Q or R

<400>  19

Met Ala Xaa Phe Gln Ser Lys Arg Arg Ile Val Gly Asn Xaa Val Lys 
1               5                   10                  15      


Glu Gln Cys Leu Lys Ala Val Asp Gly Lys Val Ile Leu Thr Asp Gln 
            20                  25                  30          


Glu Lys Arg Glu Leu Ile Lys Arg Tyr Glu Leu His Leu Glu Pro Xaa 
        35                  40                  45              


Lys Trp Leu Leu Arg Leu Phe Leu Ser Gly Tyr Glu Gly Arg Asp Asp 
    50                  55                  60                  


Gly Phe Tyr Glu Glu Leu Gly Asn Thr Asn Leu Asp Lys Glu Lys Phe 
65                  70                  75                  80  


Phe Glu Val Thr Ala Gly Leu Arg Asp Ala Leu Leu Arg Gln Ser Gly 
                85                  90                  95      


Ser Ser Arg Ala Leu Lys Ser Ser Met Leu Gly Lys Cys Pro Pro Ser 
            100                 105                 110         


Ala Ala Val Gly Lys Ala Ala Lys His Ile Gln Xaa Leu Arg Asp Ala 
        115                 120                 125             


Gly Ile Leu Pro Phe Lys Thr Gly Leu Thr Ser Gly Glu Asp Tyr Asn 
    130                 135                 140                 


Val Leu Gln Gln Ala Val Gln Gln Leu Arg Ser Trp Val Ala Cys Asp 
145                 150                 155                 160 


His Arg Thr Arg Glu Ala Tyr Ala Glu Gln Gln Glu Lys Thr Ser Gln 
                165                 170                 175     


Ala Glu Glu Ala Ala Lys Lys Ala Ala Asn Glu Val Lys Pro Glu Asp 
            180                 185                 190         


Ala Lys Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Leu Glu Arg His Glu Arg Xaa Xaa Xaa Xaa Val Leu Thr 
    210                 215                 220                 


Lys Leu Arg Lys Gln Glu Arg Arg Leu Glu Arg Met Lys Ser His Ala 
225                 230                 235                 240 


Gln Phe Ser Leu Asp Glu Met Asp Cys Thr Gly Tyr Ser Leu Cys Met 
                245                 250                 255     


Gly Ala Asn Tyr Leu Lys Asp Tyr Cys Leu Glu Lys Glu Gly Arg Gly 
            260                 265                 270         


Leu Arg Leu Thr Leu Lys Asn Ser Thr Met Ala Gly Ser Tyr Tyr Val 
        275                 280                 285             


Ser Val Gly Asp Gly Gln His Ala Gly Met Lys Asn Pro Gly Thr Pro 
    290                 295                 300                 


Ala Gly Gly Xaa Xaa Xaa Xaa Ser Pro Glu Lys Gly Arg Arg Arg Asn 
305                 310                 315                 320 


Ile Leu Phe Asp Phe Thr Val Glu Lys Cys Gly Asp Asn Tyr Leu Phe 
                325                 330                 335     


Arg Tyr Asp Glu Asn Gly Lys Arg Pro Arg Ala Gly Val Val Lys Glu 
            340                 345                 350         


Pro Arg Phe Cys Trp Arg Arg Lys Gly Asn Ser Val Glu Leu Tyr Leu 
        355                 360                 365             


Ala Met Pro Ile Asn Ile Glu Asn Ser Met Arg Asn Ile Phe Val Gly 
    370                 375                 380                 


Lys Gln Lys Ser Gly Lys His Ser Ala Phe Thr Arg Gln Trp Pro Lys 
385                 390                 395                 400 


Glu Val Glu Gly Leu Asp Glu Leu Arg Asp Ala Val Val Leu Gly Val 
                405                 410                 415     


Asp Ile Gly Ile Asn Arg Ala Ala Phe Cys Ala Ala Leu Lys Thr Ser 
            420                 425                 430         


Arg Phe Glu Asn Gly Leu Pro Ala Asp Val Gln Val Met Asp Thr Thr 
        435                 440                 445             


Cys Asp Ala Leu Thr Glu Lys Gly Gln Glu Tyr Arg Gln Leu Arg Lys 
    450                 455                 460                 


Asp Ala Thr Cys Leu Ala Trp Leu Ile Arg Thr Thr Arg Arg Phe Lys 
465                 470                 475                 480 


Ala Asp Pro Gly Asn Lys His Asn Gln Ile Lys Glu Lys Asp Val Glu 
                485                 490                 495     


Arg Phe Asp Ser Ala Asp Gly Ala Tyr Arg Arg Tyr Met Asp Ala Ile 
            500                 505                 510         


Ala Glu Met Pro Ser Asp Pro Leu Gln Val Trp Glu Ala Ala Arg Ile 
        515                 520                 525             


Thr Gly Tyr Gly Glu Trp Ala Lys Glu Ile Phe Ala Arg Phe Asn His 
    530                 535                 540                 


Tyr Lys His Glu His Ala Cys Cys Xaa Val Ser Leu Ser Leu Ser Asp 
545                 550                 555                 560 


Arg Leu Val Trp Cys Arg Leu Ile Asp Arg Ile Leu Ser Leu Lys Lys 
                565                 570                 575     


Cys Leu His Phe Gly Gly Tyr Glu Ser Lys His Arg Lys Gly Phe Cys 
            580                 585                 590         


Lys Ser Leu Tyr Arg Leu Arg His Asn Ala Arg Asn Asp Val Arg Lys 
        595                 600                 605             


Lys Leu Ala Arg Phe Xaa Val Asp Ala Ala Val Asp Ala Gly Ala Ser 
    610                 615                 620                 


Val Ile Ala Met Glu Lys Leu Pro Ser Ser Gly Gly Lys Gln Ser Lys 
625                 630                 635                 640 


Asp Asp Asn Arg Ile Trp Asp Leu Met Ala Pro Asn Thr Leu Ala Thr 
                645                 650                 655     


Thr Val Cys Leu Met Ala Lys Val Glu Gly Ile Gly Phe Val Gln Val 
            660                 665                 670         


Asp Pro Glu Phe Thr Ser Gln Trp Val Phe Glu Gln Arg Val Ile Gly 
        675                 680                 685             


Asp Arg Glu Gly Arg Ile Val Ser Cys Leu Asp Ala Glu Gly Val Arg 
    690                 695                 700                 


Arg Asp Tyr Asp Ala Asp Glu Asn Ala Ala Lys Asn Ile Ala Trp Leu 
705                 710                 715                 720 


Ala Leu Thr Arg Glu Ala Glu Pro Phe Cys Met Ala Phe Glu Lys Arg 
                725                 730                 735     


Asn Gly Val Val Glu Pro Lys Gly Xaa Arg Phe Asp Ile Pro Glu Glu 
            740                 745                 750         


Pro Thr Arg Glu Gln Asp Glu Ser Xaa Gln Asp Phe Lys Lys Arg Leu 
        755                 760                 765             


Glu Glu Arg Asp Lys Leu Ile Glu Arg Leu Gln Ala Lys Ala Asp Arg 
    770                 775                 780                 


Met Xaa Ala Ile Val Gln Arg Leu Phe Gly Asp Arg Arg Pro Trp Asp 
785                 790                 795                 800 


Ala Phe Ala Asp Arg Ile Pro Glu Gly Lys Ser Lys Arg Leu Phe Arg 
                805                 810                 815     


His Arg Asp Gly Leu Val Leu Asn Lys Pro Phe Lys Gly Leu Cys Gly 
            820                 825                 830         


Ser Glu Asn Ser Glu Gln Lys Ala Ser Ala Arg Asn Ser Arg 
        835                 840                 845     


<210>  20
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIG. 1B Consensus Sequence

<400>  20

Met Ala Phe Gln Ser Lys Arg Arg Ile Val Gly Asn Phe Val Lys Glu 
1               5                   10                  15      


Gln Cys Leu Lys Ala Val Asp Gly Lys Val Ile Leu Thr Asp Gln Glu 
            20                  25                  30          


Lys Arg Glu Leu Ile Lys Arg Tyr Glu Leu His Leu Glu Pro His Lys 
        35                  40                  45              


Trp Leu Leu Arg Leu Phe Leu Ser Gly Tyr Glu Gly Arg Asp Asp Gly 
    50                  55                  60                  


Phe Tyr Glu Glu Leu Gly Asn Thr Asn Leu Asp Lys Glu Lys Phe Phe 
65                  70                  75                  80  


Glu Val Thr Ala Gly Leu Arg Asp Ala Leu Leu Arg Gln Ser Gly Ser 
                85                  90                  95      


Ser Arg Ala Leu Lys Ser Ser Met Leu Gly Lys Cys Pro Pro Ser Ala 
            100                 105                 110         


Ala Val Gly Lys Ala Ala Lys His Ile Gln Thr Leu Arg Asp Ala Gly 
        115                 120                 125             


Ile Leu Pro Phe Lys Thr Gly Leu Thr Ser Gly Glu Asp Tyr Asn Val 
    130                 135                 140                 


Leu Gln Gln Ala Val Gln Gln Leu Arg Ser Trp Val Ala Cys Asp His 
145                 150                 155                 160 


Arg Thr Arg Glu Ala Tyr Ala Glu Gln Gln Glu Lys Thr Ser Gln Ala 
                165                 170                 175     


Glu Glu Ala Ala Lys Lys Ala Ala Asn Glu Val Lys Pro Glu Asp Ala 
            180                 185                 190         


Lys Ser Leu Glu Arg His Glu Arg Val Leu Thr Lys Leu Arg Lys Gln 
        195                 200                 205             


Glu Arg Arg Leu Glu Arg Met Lys Ser His Ala Gln Phe Ser Leu Asp 
    210                 215                 220                 


Glu Met Asp Cys Thr Gly Tyr Ser Leu Cys Met Gly Ala Asn Tyr Leu 
225                 230                 235                 240 


Lys Asp Tyr Cys Leu Glu Lys Glu Gly Arg Gly Leu Arg Leu Thr Leu 
                245                 250                 255     


Lys Asn Ser Thr Met Ala Gly Ser Tyr Tyr Val Ser Val Gly Asp Gly 
            260                 265                 270         


Gln His Ala Gly Met Lys Asn Pro Gly Thr Pro Ala Gly Gly Ser Pro 
        275                 280                 285             


Glu Lys Gly Arg Arg Arg Asn Ile Leu Phe Asp Phe Thr Val Glu Lys 
    290                 295                 300                 


Cys Gly Asp Asn Tyr Leu Phe Arg Tyr Asp Glu Asn Gly Lys Arg Pro 
305                 310                 315                 320 


Arg Ala Gly Val Val Lys Glu Pro Arg Phe Cys Trp Arg Arg Lys Gly 
                325                 330                 335     


Asn Ser Val Glu Leu Tyr Leu Ala Met Pro Ile Asn Ile Glu Asn Ser 
            340                 345                 350         


Met Arg Asn Ile Phe Val Gly Lys Gln Lys Ser Gly Lys His Ser Ala 
        355                 360                 365             


Phe Thr Arg Gln Trp Pro Lys Glu Val Glu Gly Leu Asp Glu Leu Arg 
    370                 375                 380                 


Asp Ala Val Val Leu Gly Val Asp Ile Gly Ile Asn Arg Ala Ala Phe 
385                 390                 395                 400 


Cys Ala Ala Leu Lys Thr Ser Arg Phe Glu Asn Gly Leu Pro Ala Asp 
                405                 410                 415     


Val Gln Val Met Asp Thr Thr Cys Asp Ala Leu Thr Glu Lys Gly Gln 
            420                 425                 430         


Glu Tyr Arg Gln Leu Arg Lys Asp Ala Thr Cys Leu Ala Trp Leu Ile 
        435                 440                 445             


Arg Thr Thr Arg Arg Phe Lys Ala Asp Pro Gly Asn Lys His Asn Gln 
    450                 455                 460                 


Ile Lys Glu Lys Asp Val Glu Arg Phe Asp Ser Ala Asp Gly Ala Tyr 
465                 470                 475                 480 


Arg Arg Tyr Met Asp Ala Ile Ala Glu Met Pro Ser Asp Pro Leu Gln 
                485                 490                 495     


Val Trp Glu Ala Ala Arg Ile Thr Gly Tyr Gly Glu Trp Ala Lys Glu 
            500                 505                 510         


Ile Phe Ala Arg Phe Asn His Tyr Lys His Glu His Ala Cys Cys Ala 
        515                 520                 525             


Val Ser Leu Ser Leu Ser Asp Arg Leu Val Trp Cys Arg Leu Ile Asp 
    530                 535                 540                 


Arg Ile Leu Ser Leu Lys Lys Cys Leu His Phe Gly Gly Tyr Glu Ser 
545                 550                 555                 560 


Lys His Arg Lys Gly Phe Cys Lys Ser Leu Tyr Arg Leu Arg His Asn 
                565                 570                 575     


Ala Arg Asn Asp Val Arg Lys Lys Leu Ala Arg Phe Ile Val Asp Ala 
            580                 585                 590         


Ala Val Asp Ala Gly Ala Ser Val Ile Ala Met Glu Lys Leu Pro Ser 
        595                 600                 605             


Ser Gly Gly Lys Gln Ser Lys Asp Asp Asn Arg Ile Trp Asp Leu Met 
    610                 615                 620                 


Ala Pro Asn Thr Leu Ala Thr Thr Val Cys Leu Met Ala Lys Val Glu 
625                 630                 635                 640 


Gly Ile Gly Phe Val Gln Val Asp Pro Glu Phe Thr Ser Gln Trp Val 
                645                 650                 655     


Phe Glu Gln Arg Val Ile Gly Asp Arg Glu Gly Arg Ile Val Ser Cys 
            660                 665                 670         


Leu Asp Ala Glu Gly Val Arg Arg Asp Tyr Asp Ala Asp Glu Asn Ala 
        675                 680                 685             


Ala Lys Asn Ile Ala Trp Leu Ala Leu Thr Arg Glu Ala Glu Pro Phe 
    690                 695                 700                 


Cys Met Ala Phe Glu Lys Arg Asn Gly Val Val Glu Pro Lys Gly Leu 
705                 710                 715                 720 


Arg Phe Asp Ile Pro Glu Glu Pro Thr Arg Glu Gln Asp Glu Ser Asp 
                725                 730                 735     


Gln Asp Phe Lys Lys Arg Leu Glu Glu Arg Asp Lys Leu Ile Glu Arg 
            740                 745                 750         


Leu Gln Ala Lys Ala Asp Arg Met Gln Ala Ile Val Gln Arg Leu Phe 
        755                 760                 765             


Gly Asp Arg Arg Pro Trp Asp Ala Phe Ala Asp Arg Ile Pro Glu Gly 
    770                 775                 780                 


Lys Ser Lys Arg Leu Phe Arg His Arg Asp Gly Leu Val Leu Asn Lys 
785                 790                 795                 800 


Pro Phe Lys Gly Leu Cys Gly Ser Glu Asn Ser Glu Gln Lys Ala Ser 
                805                 810                 815     


Ala Arg Asn Ser Arg 
            820     


