                         SEQUENCE LISTING

<110>  The Brigham and Women's Hospital, Inc.
       The Broad Institute, Inc.
       The General Hospital Corporation
       The Regents of the University of California
 
<120>  MODULATION OF A PATHOGENIC PHENOTYPE IN TH1 CELLS

<130>  BROD-5340WP

<150>  US 63/140,458
<151>  2021-01-22

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  401
<212>  PRT
<213>  Ktedonobacter racemifer

<400>  1

Met Ser Thr Asp Ala Thr Leu Ile Arg Thr Thr Pro Ser His Ala Glu 
1               5                   10                  15      


Ala Asp Ala Thr Asp Thr Leu Val Ala Thr Pro Leu Met Pro Pro Arg 
            20                  25                  30          


Arg Val Ile Ser Pro Trp Pro Gly Pro Gly Glu Gly Gln Ser Leu Met 
        35                  40                  45              


Arg Ile Pro Val Val Asp Ile Arg Gly Met Ala Leu Met Pro Cys Thr 
    50                  55                  60                  


Pro Ala Lys Ala Arg His Leu Leu Lys Ser Gly Asn Ala Arg Pro Lys 
65                  70                  75                  80  


Arg Asn Lys Leu Gly Leu Phe Tyr Val Gln Leu Ser Tyr Glu Gln Glu 
                85                  90                  95      


Pro Asp Asn Gln Ser Leu Val Ala Gly Val Asp Pro Gly Ser Lys Phe 
            100                 105                 110         


Glu Gly Leu Ser Val Val Gly Thr Lys Asp Thr Val Leu Asn Leu Met 
        115                 120                 125             


Val Glu Ala Pro Asp His Val Lys Gly Ala Val Gln Thr Arg Arg Thr 
    130                 135                 140                 


Met Arg Arg Ala Arg Arg Gln Arg Lys Trp Arg Arg Pro Lys Arg Phe 
145                 150                 155                 160 


His Asn Arg Leu Asn Arg Met Gln Arg Ile Pro Pro Ser Thr Arg Ser 
                165                 170                 175     


Arg Trp Glu Ala Lys Ala Arg Ile Val Ala His Leu Arg Thr Ile Leu 
            180                 185                 190         


Pro Phe Thr Asp Val Val Val Glu Asp Val Gln Ala Val Thr Arg Lys 
        195                 200                 205             


Gly Lys Gly Gly Thr Trp Asn Gly Ser Phe Ser Pro Val Gln Val Gly 
    210                 215                 220                 


Lys Glu His Leu Tyr Arg Leu Leu Arg Ala Met Gly Leu Thr Leu His 
225                 230                 235                 240 


Leu Arg Glu Gly Trp Gln Thr Lys Glu Leu Arg Glu Gln His Gly Leu 
                245                 250                 255     


Lys Lys Thr Lys Ser Lys Ser Lys Gln Ser Phe Glu Ser His Ala Val 
            260                 265                 270         


Asp Ser Trp Val Leu Ala Ala Ser Ile Ser Gly Ala Glu His Pro Thr 
        275                 280                 285             


Cys Thr Arg Leu Trp Tyr Met Val Pro Ala Ile Leu His Arg Arg Gln 
    290                 295                 300                 


Leu His Arg Leu Gln Ala Ser Lys Gly Gly Val Arg Lys Pro Tyr Gly 
305                 310                 315                 320 


Gly Thr Arg Ser Leu Gly Val Lys Arg Gly Thr Leu Val Glu His Lys 
                325                 330                 335     


Lys Tyr Gly Arg Cys Thr Val Gly Gly Val Asp Arg Lys Arg Asn Thr 
            340                 345                 350         


Ile Ser Leu His Glu Tyr Arg Thr Asn Thr Arg Leu Thr Gln Ala Ala 
        355                 360                 365             


Lys Val Glu Thr Cys Arg Val Leu Thr Trp Leu Ser Trp Arg Ser Trp 
    370                 375                 380                 


Leu Leu Arg Gly Lys Arg Thr Ser Ser Lys Gly Lys Gly Ser His Ser 
385                 390                 395                 400 


Ser 
    


<210>  2
<211>  432
<212>  PRT
<213>  Oscillatoriales cyanobacterium

<400>  2

Met Gln Pro Ala Lys Gln Gln Asn Trp Val Phe Gln Ile Asn Gly Asp 
1               5                   10                  15      


Lys Gln Pro Leu Asp Met Ile Asn Pro Gly Arg Cys Arg Glu Leu Gln 
            20                  25                  30          


Asn Arg Gly Lys Leu Ala Ser Phe Arg Arg Phe Pro Tyr Val Val Ile 
        35                  40                  45              


Gln Gln Gln Thr Ile Glu Asn Pro Gln Thr Lys Glu Tyr Ile Leu Lys 
    50                  55                  60                  


Ile Asp Pro Gly Ser Gln Trp Thr Gly Phe Ala Ile Gln Cys Gly Asn 
65                  70                  75                  80  


Asp Ile Leu Phe Arg Ala Glu Leu Asn His Arg Gly Glu Ala Ile Lys 
                85                  90                  95      


Phe Asp Leu Val Lys Arg Ala Trp Phe Arg Arg Gly Arg Arg Ser Arg 
            100                 105                 110         


Asn Leu Arg Tyr Arg Lys Lys Arg Leu Asn Arg Ala Lys Pro Glu Gly 
        115                 120                 125             


Trp Leu Ala Pro Ser Ile Arg His Arg Val Leu Thr Val Glu Thr Trp 
    130                 135                 140                 


Ile Lys Arg Phe Met Arg Tyr Cys Pro Ile Ala Trp Ile Glu Ile Glu 
145                 150                 155                 160 


Gln Val Arg Phe Asp Thr Gln Lys Leu Ala Asn Pro Glu Ile Asp Gly 
                165                 170                 175     


Val Glu Tyr Gln Gln Gly Glu Leu Gln Gly Tyr Glu Val Arg Glu Tyr 
            180                 185                 190         


Leu Leu Gln Lys Trp Gly Arg Lys Cys Ala Tyr Cys Gly Thr Glu Asn 
        195                 200                 205             


Val Pro Leu Glu Val Glu His Ile Gln Ser Lys Ser Lys Gly Gly Ser 
    210                 215                 220                 


Ser Arg Ile Gly Asn Leu Thr Leu Ala Cys His Val Cys Asn Val Lys 
225                 230                 235                 240 


Lys Gly Asn Leu Asp Val Arg Asp Phe Leu Ala Lys Ser Pro Asp Ile 
                245                 250                 255     


Leu Asn Gln Val Leu Glu Asn Ser Thr Lys Pro Leu Lys Asp Ala Ala 
            260                 265                 270         


Ala Val Asn Ser Thr Arg Tyr Ala Ile Val Lys Met Ala Lys Ser Ile 
        275                 280                 285             


Cys Glu Asn Val Lys Cys Ser Ser Gly Ala Arg Thr Lys Met Asn Arg 
    290                 295                 300                 


Val Arg Gln Gly Leu Glu Lys Thr His Ser Leu Asp Ala Ala Cys Val 
305                 310                 315                 320 


Gly Glu Ser Gly Ala Ser Ile Arg Val Leu Thr Asp Arg Pro Leu Leu 
                325                 330                 335     


Ile Thr Cys Lys Gly His Gly Ser Arg Gln Ser Ile Arg Val Asn Ala 
            340                 345                 350         


Ser Gly Phe Pro Ala Val Lys Asn Ala Lys Thr Val Phe Thr His Ile 
        355                 360                 365             


Ala Ala Gly Asp Val Val Arg Phe Thr Ile Gly Lys Asp Arg Lys Lys 
    370                 375                 380                 


Ala Gln Ala Gly Thr Tyr Thr Ala Arg Val Lys Thr Pro Thr Pro Lys 
385                 390                 395                 400 


Gly Phe Glu Val Leu Ile Asp Gly Ala Arg Ile Ser Leu Ser Thr Met 
                405                 410                 415     


Ser Asn Val Val Phe Val His Arg Ser Asp Gly Tyr Gly Tyr Glu Leu 
            420                 425                 430         


<210>  3
<211>  461
<212>  PRT
<213>  Acidihalobacter prosperus

<400>  3

Met Ala Val Phe Val Ile Asp Lys His Lys Arg Pro Leu Met Pro Cys 
1               5                   10                  15      


Ser Glu Lys Arg Ala Arg Leu Leu Leu Glu Arg Gly Arg Ala Val Val 
            20                  25                  30          


His Arg Gln Val Pro Phe Val Ile Arg Leu Lys Asp Arg Thr Val Gln 
        35                  40                  45              


His Ser Ala Val Gln Pro Leu Arg Val Ala Leu Asp Pro Gly Ser Arg 
    50                  55                  60                  


Ala Thr Gly Met Ala Leu Val Arg Glu Lys Asn Thr Val Asp Thr Gly 
65                  70                  75                  80  


Thr Gly Glu Val Tyr Arg Glu Arg Ile Ala Leu Asn Leu Phe Glu Leu 
                85                  90                  95      


Val His Arg Gly His Arg Ile Arg Glu Gln Leu Asp Gln Arg Arg Asn 
            100                 105                 110         


Phe Arg Arg Arg Arg Arg Gly Ala Asn Leu Arg Tyr Arg Ala Pro Arg 
        115                 120                 125             


Phe Asp Asn Arg Arg Arg Pro Pro Gly Trp Leu Ala Pro Ser Leu Gln 
    130                 135                 140                 


His Arg Val Asp Thr Thr Met Ala Trp Val Arg Arg Leu Cys Arg Trp 
145                 150                 155                 160 


Ala Pro Ala Ser Ala Ile Gly Ile Glu Thr Val Arg Phe Asp Thr Gln 
                165                 170                 175     


Arg Leu Gln Asn Pro Glu Ile Ser Gly Val Glu Tyr Gln Gln Gly Ala 
            180                 185                 190         


Leu Ala Gly Cys Glu Val Arg Glu Tyr Leu Leu Glu Lys Trp Gly Arg 
        195                 200                 205             


Lys Cys Ala Tyr Cys Gly Ala Glu Asn Val Pro Leu Glu Ile Glu His 
    210                 215                 220                 


Ile Val Pro Lys Ser Arg Gly Gly Ser Asp Arg Val Ser Asn Leu Ala 
225                 230                 235                 240 


Leu Ala Cys Arg Ala Cys Asn Gln Ala Lys Gly Asn Arg Asp Val Arg 
                245                 250                 255     


Ala Phe Leu Ala Asp Gln Pro Glu Arg Leu Ala Arg Ile Leu Ala Gln 
            260                 265                 270         


Ala Lys Ala Pro Leu Lys Asp Ala Ala Ala Val Asn Ala Thr Arg Trp 
        275                 280                 285             


Ala Leu Tyr Arg Ala Leu Val Asp Thr Gly Leu Pro Val Glu Ala Gly 
    290                 295                 300                 


Thr Gly Gly Arg Thr Lys Trp Asn Arg Thr Arg Leu Gly Leu Pro Lys 
305                 310                 315                 320 


Thr His Ala Leu Asp Ala Leu Cys Val Gly Gln Val Asp Gln Val Arg 
                325                 330                 335     


His Trp Arg Val Pro Val Leu Gly Ile Arg Cys Ala Gly Arg Gly Ser 
            340                 345                 350         


Tyr Arg Arg Thr Arg Leu Thr Arg His Gly Phe Pro Arg Gly Tyr Leu 
        355                 360                 365             


Thr Arg Asn Lys Ser Ala Phe Gly Phe Gln Thr Gly Asp Leu Ile Arg 
    370                 375                 380                 


Ala Val Val Thr Lys Gly Lys Lys Ala Gly Thr Tyr Leu Gly Arg Ile 
385                 390                 395                 400 


Ala Ile Arg Ala Ser Gly Ser Phe Asn Ile Gln Thr Pro Met Gly Val 
                405                 410                 415     


Val Gln Gly Ile His His Arg Phe Cys Thr Leu Leu Gln Arg Ala Asp 
            420                 425                 430         


Gly Tyr Gly Tyr Phe Val Gln Pro Lys Pro Thr Glu Ala Ala Leu Ser 
        435                 440                 445             


Ser Pro Arg Leu Lys Ala Gly Val Ser Ser Ala Gly Asn 
    450                 455                 460     


<210>  4
<211>  439
<212>  PRT
<213>  Tolypothrix campylonemoides

<400>  4

Met Thr Thr Asn Val Val Phe Val Ile Asp Thr Asn Gln Lys Pro Leu 
1               5                   10                  15      


Gln Pro Cys Ser Ala Ala Val Ala Arg Lys Leu Leu Leu Arg Gly Lys 
            20                  25                  30          


Ala Ala Met Phe Arg Arg Tyr Pro Ala Val Ile Ile Leu Lys Lys Glu 
        35                  40                  45              


Val Asp Ser Val Gly Lys Pro Lys Ile Glu Leu Arg Ile Asp Pro Gly 
    50                  55                  60                  


Ser Lys Tyr Thr Gly Phe Ala Leu Val Asp Ser Lys Asp Asn Ala Asp 
65                  70                  75                  80  


Phe Ile Ile Trp Gly Thr Glu Leu Glu His Arg Gly Ala Ala Ile Cys 
                85                  90                  95      


Lys Glu Leu Thr Lys Arg Ser Ala Ile Arg Arg Ser Arg Arg Asn Arg 
            100                 105                 110         


Lys Thr Arg Tyr Arg Lys Lys Arg Phe Glu Arg Arg Lys Pro Glu Gly 
        115                 120                 125             


Trp Leu Ala Pro Ser Leu Gln His Arg Val Asp Thr Thr Leu Thr Trp 
    130                 135                 140                 


Val Lys Arg Ile Cys Lys Phe Val Pro Ile Met Ser Ile Ser Val Glu 
145                 150                 155                 160 


Gln Val Lys Phe Asp Leu Gln Lys Leu Glu Asn Ser Asp Ile Gln Gly 
                165                 170                 175     


Ile Glu Tyr Gln Gln Gly Thr Leu Ala Gly Tyr Thr Leu Arg Glu Ala 
            180                 185                 190         


Leu Leu Glu His Trp Gly Arg Lys Cys Ala Tyr Cys Asp Val Glu Asn 
        195                 200                 205             


Val Phe Leu Glu Ile Glu His Ile Tyr Pro Lys Ser Lys Gly Gly Ser 
    210                 215                 220                 


Asp Lys Phe Ser Asn Leu Thr Leu Ala Cys His Lys Cys Asn Ile Asn 
225                 230                 235                 240 


Lys Gly Asn Lys Ser Ile Asp Glu Phe Leu Leu Ser Asp His Lys Arg 
                245                 250                 255     


Leu Glu Gln Ile Lys Leu His Gln Lys Lys Thr Leu Lys Asp Ala Ala 
            260                 265                 270         


Ala Val Asn Ala Thr Arg Lys Lys Leu Val Thr Thr Leu Gln Glu Lys 
        275                 280                 285             


Thr Phe Leu Asn Val Leu Val Ser Asp Gly Ala Ser Thr Lys Met Thr 
    290                 295                 300                 


Arg Leu Ser Ser Ser Leu Ala Lys Arg His Trp Ile Asp Ala Gly Cys 
305                 310                 315                 320 


Val Asn Thr Thr Leu Ile Val Ile Leu Lys Thr Leu Gln Pro Leu Gln 
                325                 330                 335     


Val Lys Cys Asn Gly His Gly Asn Lys Gln Phe Val Thr Met Asp Ala 
            340                 345                 350         


Tyr Gly Phe Pro Arg Lys Ser Tyr Glu Pro Lys Lys Val Arg Lys Asp 
        355                 360                 365             


Trp Lys Ala Gly Asp Ile Ile Arg Val Thr Lys Lys Asp Gly Thr Met 
    370                 375                 380                 


Leu Met Gly Arg Val Lys Lys Ala Ala Lys Lys Leu Val Tyr Ile Pro 
385                 390                 395                 400 


Phe Gly Gly Lys Glu Ala Ser Phe Ser Ser Glu Asn Ala Lys Ala Ile 
                405                 410                 415     


His Arg Ser Asp Gly Tyr Arg Tyr Ser Phe Ala Ala Ile Asp Ser Glu 
            420                 425                 430         


Leu Leu Gln Lys Met Ala Thr 
        435                 


<210>  5
<211>  419
<212>  PRT
<213>  Halobacteroides halobius

<400>  5

Met Pro Asn Lys Tyr Ala Phe Val Leu Asp Ser Lys Gly Lys Leu Leu 
1               5                   10                  15      


Asp Pro Thr Lys Ser Lys Lys Ala Trp Tyr Leu Ile Arg Lys Gly Lys 
            20                  25                  30          


Ala Ser Leu Val Glu Glu Tyr Pro Leu Ile Ile Lys Leu Lys Arg Glu 
        35                  40                  45              


Val Pro Lys Asp Gln Val Asn Ser Asp Lys Leu Ile Leu Gly Ile Asp 
    50                  55                  60                  


Asp Gly Thr Lys Lys Val Gly Phe Ala Leu Val Gln Lys Cys Gln Thr 
65                  70                  75                  80  


Lys Asn Lys Val Leu Phe Lys Ala Val Met Glu Gln Arg Gln Asp Val 
                85                  90                  95      


Ser Lys Lys Met Glu Glu Arg Arg Gly Tyr Arg Arg Tyr Arg Arg Ser 
            100                 105                 110         


His Lys Arg Tyr Arg Pro Ala Arg Phe Asp Asn Arg Ser Ser Ser Lys 
        115                 120                 125             


Arg Lys Gly Arg Ile Pro Pro Ser Ile Leu Gln Lys Lys Gln Ala Ile 
    130                 135                 140                 


Leu Arg Val Val Asn Lys Leu Lys Lys Tyr Ile Arg Ile Asp Lys Ile 
145                 150                 155                 160 


Val Leu Glu Asp Val Ser Ile Asp Ile Arg Lys Leu Thr Glu Gly Arg 
                165                 170                 175     


Glu Leu Tyr Asn Trp Glu Tyr Gln Glu Ser Asn Arg Leu Asp Glu Asn 
            180                 185                 190         


Leu Arg Lys Ala Thr Leu Tyr Arg Asp Asp Cys Thr Cys Gln Leu Cys 
        195                 200                 205             


Gly Thr Thr Glu Thr Met Leu His Ala His His Ile Met Pro Arg Arg 
    210                 215                 220                 


Asp Gly Gly Ala Asp Ser Ile Tyr Asn Leu Ile Thr Leu Cys Lys Ala 
225                 230                 235                 240 


Cys His Lys Asp Lys Val Asp Asn Asn Glu Tyr Gln Tyr Lys Asp Gln 
                245                 250                 255     


Phe Leu Ala Ile Ile Asp Ser Lys Glu Leu Ser Asp Leu Lys Ser Ala 
            260                 265                 270         


Ser His Val Met Gln Gly Lys Thr Trp Leu Arg Asp Lys Leu Ser Lys 
        275                 280                 285             


Ile Ala Gln Leu Glu Ile Thr Ser Gly Gly Asn Thr Ala Asn Lys Arg 
    290                 295                 300                 


Ile Asp Tyr Glu Ile Glu Lys Ser His Ser Asn Asp Ala Ile Cys Thr 
305                 310                 315                 320 


Thr Gly Leu Leu Pro Val Asp Asn Ile Asp Asp Ile Lys Glu Tyr Tyr 
                325                 330                 335     


Ile Lys Pro Leu Arg Lys Lys Ser Lys Ala Lys Ile Lys Glu Leu Lys 
            340                 345                 350         


Cys Phe Arg Gln Arg Asp Leu Val Lys Tyr Thr Lys Arg Asn Gly Glu 
        355                 360                 365             


Thr Tyr Thr Gly Tyr Ile Thr Ser Leu Arg Ile Lys Asn Asn Lys Tyr 
    370                 375                 380                 


Asn Ser Lys Val Cys Asn Phe Ser Thr Leu Lys Gly Lys Ile Phe Arg 
385                 390                 395                 400 


Gly Tyr Gly Phe Arg Asn Leu Thr Leu Leu Asn Arg Pro Lys Gly Leu 
                405                 410                 415     


Met Ile Val 
            


<210>  6
<211>  1350
<212>  PRT
<213>  Streptococcus thermophilus

<400>  6

Met Leu Phe Asn Lys Cys Ile Ile Ile Ser Ile Asn Leu Asp Phe Ser 
1               5                   10                  15      


Asn Lys Glu Lys Cys Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile 
            20                  25                  30          


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val 
        35                  40                  45              


Pro Ser Lys Lys Met Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile 
    50                  55                  60                  


Lys Lys Asn Leu Leu Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala 
65                  70                  75                  80  


Glu Gly Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
                85                  90                  95      


Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala 
            100                 105                 110         


Thr Leu Asp Asp Ala Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val 
        115                 120                 125             


Pro Asp Asp Lys Arg Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val 
    130                 135                 140                 


Glu Glu Lys Val Tyr His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg 
145                 150                 155                 160 


Lys Tyr Leu Ala Asp Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr 
                165                 170                 175     


Leu Ala Leu Ala His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu 
            180                 185                 190         


Gly Glu Phe Asn Ser Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp 
        195                 200                 205             


Phe Leu Asp Thr Tyr Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu 
    210                 215                 220                 


Asn Ser Lys Gln Leu Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu 
225                 230                 235                 240 


Glu Lys Lys Asp Arg Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser 
                245                 250                 255     


Gly Ile Phe Ser Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp 
            260                 265                 270         


Phe Arg Lys Cys Phe Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser 
        275                 280                 285             


Lys Glu Ser Tyr Asp Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly 
    290                 295                 300                 


Asp Asp Tyr Ser Asp Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala 
305                 310                 315                 320 


Ile Leu Leu Ser Gly Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala 
                325                 330                 335     


Pro Leu Ser Ser Ala Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp 
            340                 345                 350         


Leu Ala Leu Leu Lys Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr 
        355                 360                 365             


Asn Glu Val Phe Lys Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile 
    370                 375                 380                 


Asp Gly Lys Thr Asn Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu 
385                 390                 395                 400 


Leu Ala Glu Phe Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg 
                405                 410                 415     


Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
            420                 425                 430         


Tyr Gln Ile His Leu Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala 
        435                 440                 445             


Lys Phe Tyr Pro Phe Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile 
    450                 455                 460                 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
465                 470                 475                 480 


Ser Asp Phe Ala Trp Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro 
                485                 490                 495     


Trp Asn Phe Glu Asp Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe 
            500                 505                 510         


Ile Asn Arg Met Thr Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val 
        515                 520                 525             


Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu 
    530                 535                 540                 


Leu Thr Lys Val Arg Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe 
545                 550                 555                 560 


Leu Asp Ser Lys Gln Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp 
                565                 570                 575     


Lys Arg Lys Val Thr Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile 
            580                 585                 590         


Tyr Gly Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn 
        595                 600                 605             


Ser Ser Leu Ser Thr Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys 
    610                 615                 620                 


Glu Phe Leu Asp Asp Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile 
625                 630                 635                 640 


His Thr Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu 
                645                 650                 655     


Ser Lys Phe Glu Asn Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser 
            660                 665                 670         


Arg Arg His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn 
        675                 680                 685             


Gly Ile Arg Asp Glu Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile 
    690                 695                 700                 


Asp Asp Gly Ile Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
705                 710                 715                 720 


Ala Leu Ser Phe Lys Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp 
                725                 730                 735     


Glu Asp Lys Gly Asn Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser 
            740                 745                 750         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu 
        755                 760                 765             


Leu Val Lys Val Met Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu 
    770                 775                 780                 


Met Ala Arg Glu Asn Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln 
785                 790                 795                 800 


Gln Arg Leu Lys Arg Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys 
                805                 810                 815     


Ile Leu Lys Glu Asn Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn 
            820                 825                 830         


Ala Leu Gln Asn Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys 
        835                 840                 845             


Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr 
    850                 855                 860                 


Asp Ile Asp His Ile Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile 
865                 870                 875                 880 


Asp Asn Lys Val Leu Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp 
                885                 890                 895     


Asp Phe Pro Ser Leu Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr 
            900                 905                 910         


Gln Leu Leu Lys Ser Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu 
        915                 920                 925             


Thr Lys Ala Glu Arg Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe 
    930                 935                 940                 


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 
945                 950                 955                 960 


Arg Leu Leu Asp Glu Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg 
                965                 970                 975     


Ala Val Arg Thr Val Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser 
            980                 985                 990         


Gln Phe Arg Lys Asp Phe Glu Leu  Tyr Lys Val Arg Glu  Ile Asn Asp 
        995                 1000                 1005             


Phe His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Ile Ala Ser 
    1010                 1015                 1020             


Ala Leu  Leu Lys Lys Tyr Pro  Lys Leu Glu Pro Glu  Phe Val Tyr 
    1025                 1030                 1035             


Gly Asp  Tyr Pro Lys Tyr Asn  Ser Phe Arg Glu Arg  Lys Ser Ala 
    1040                 1045                 1050             


Thr Glu  Lys Val Tyr Phe Tyr  Ser Asn Ile Met Asn  Ile Phe Lys 
    1055                 1060                 1065             


Lys Ser  Ile Ser Leu Ala Asp  Gly Arg Val Ile Glu  Arg Pro Leu 
    1070                 1075                 1080             


Ile Glu  Val Asn Glu Glu Thr  Gly Glu Ser Val Trp  Asn Lys Glu 
    1085                 1090                 1095             


Ser Asp  Leu Ala Thr Val Arg  Arg Val Leu Ser Tyr  Pro Gln Val 
    1100                 1105                 1110             


Asn Val  Val Lys Lys Val Glu  Glu Gln Asn His Gly  Leu Asp Arg 
    1115                 1120                 1125             


Gly Lys  Pro Lys Gly Leu Phe  Asn Ala Asn Leu Ser  Ser Lys Pro 
    1130                 1135                 1140             


Lys Pro  Asn Ser Asn Glu Asn  Leu Val Gly Ala Lys  Glu Tyr Leu 
    1145                 1150                 1155             


Asp Pro  Lys Lys Tyr Gly Gly  Tyr Ala Gly Ile Ser  Asn Ser Phe 
    1160                 1165                 1170             


Ala Val  Leu Val Lys Gly Thr  Ile Glu Lys Gly Ala  Lys Lys Lys 
    1175                 1180                 1185             


Ile Thr  Asn Val Leu Glu Phe  Gln Gly Ile Ser Ile  Leu Asp Arg 
    1190                 1195                 1200             


Ile Asn  Tyr Arg Lys Asp Lys  Leu Asn Phe Leu Leu  Glu Lys Gly 
    1205                 1210                 1215             


Tyr Lys  Asp Ile Glu Leu Ile  Ile Glu Leu Pro Lys  Tyr Ser Leu 
    1220                 1225                 1230             


Phe Glu  Leu Ser Asp Gly Ser  Arg Arg Met Leu Ala  Ser Ile Leu 
    1235                 1240                 1245             


Ser Thr  Asn Asn Lys Arg Gly  Glu Ile His Lys Gly  Asn Gln Ile 
    1250                 1255                 1260             


Phe Leu  Ser Gln Lys Phe Val  Lys Leu Leu Tyr His  Ala Lys Arg 
    1265                 1270                 1275             


Ile Ser  Asn Thr Ile Asn Glu  Asn His Arg Lys Tyr  Val Glu Asn 
    1280                 1285                 1290             


His Lys  Lys Glu Phe Glu Glu  Leu Phe Tyr Tyr Ile  Leu Glu Phe 
    1295                 1300                 1305             


Asn Glu  Asn Tyr Val Gly Ala  Lys Lys Asn Gly Lys  Leu Leu Asn 
    1310                 1315                 1320             


Ser Ala  Phe Gln Ser Trp Gln  Asn His Ser Ile Asp  Glu Leu Cys 
    1325                 1330                 1335             


Ser Ser  Phe Ile Gly Pro Thr  Gly Ser Glu Arg Lys  
    1340                 1345                 1350 


<210>  7
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  7

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  8
<211>  1365
<212>  PRT
<213>  Streptococcus pyogenes

<400>  8

Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala 
1               5                   10                  15      


Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu 
            20                  25                  30          


Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu 
        35                  40                  45              


Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr 
    50                  55                  60                  


Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln 
65                  70                  75                  80  


Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His 
                85                  90                  95      


Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg 
            100                 105                 110         


His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys 
        115                 120                 125             


Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp 
    130                 135                 140                 


Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys 
145                 150                 155                 160 


Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser 
                165                 170                 175     


Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu 
            180                 185                 190         


Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile 
        195                 200                 205             


Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala 
    210                 215                 220                 


Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala 
225                 230                 235                 240 


Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala 
                245                 250                 255     


Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu 
            260                 265                 270         


Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu 
        275                 280                 285             


Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg 
    290                 295                 300                 


Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys 
305                 310                 315                 320 


Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val 
                325                 330                 335     


Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser 
            340                 345                 350         


Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu 
        355                 360                 365             


Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu 
    370                 375                 380                 


Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg 
385                 390                 395                 400 


Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu 
                405                 410                 415     


His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp 
            420                 425                 430         


Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr 
        435                 440                 445             


Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg 
    450                 455                 460                 


Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp 
465                 470                 475                 480 


Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp 
                485                 490                 495     


Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr 
            500                 505                 510         


Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr 
        515                 520                 525             


Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala 
    530                 535                 540                 


Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln 
545                 550                 555                 560 


Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu 
                565                 570                 575     


Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His 
            580                 585                 590         


Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu 
        595                 600                 605             


Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu 
    610                 615                 620                 


Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe 
625                 630                 635                 640 


Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp 
                645                 650                 655     


Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser 
            660                 665                 670         


Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg 
        675                 680                 685             


Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp 
    690                 695                 700                 


Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His 
705                 710                 715                 720 


Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
                725                 730                 735     


Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys 
            740                 745                 750         


Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln 
        755                 760                 765             


Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly 
    770                 775                 780                 


Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn 
785                 790                 795                 800 


Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly 
                805                 810                 815     


Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp 
            820                 825                 830         


Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser 
        835                 840                 845             


Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser 
    850                 855                 860                 


Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp 
865                 870                 875                 880 


Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn 
                885                 890                 895     


Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp 
    930                 935                 940                 


Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val 
945                 950                 955                 960 


Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr 
            980                 985                 990         


Ala Leu Ile Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1010                 1015                 1020             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1025                 1030                 1035             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1040                 1045                 1050             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1055                 1060                 1065             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1070                 1075                 1080             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1085                 1090                 1095             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1100                 1105                 1110             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1115                 1120                 1125             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1130                 1135                 1140             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1145                 1150                 1155             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1160                 1165                 1170             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1175                 1180                 1185             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1190                 1195                 1200             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1205                 1210                 1215             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1220                 1225                 1230             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1235                 1240                 1245             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1250                 1255                 1260             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1265                 1270                 1275             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1280                 1285                 1290             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1295                 1300                 1305             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1310                 1315                 1320             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1325                 1330                 1335             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1340                 1345                 1350             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  
    1355                 1360                 1365 


<210>  9
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthethic

<400>  9

Met Asp Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu 
1               5                   10                  15      


Ser Gly Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val 
            20                  25                  30          


Ser Pro Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr 
        35                  40                  45              


Met Ser Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe 
    50                  55                  60                  


Ser Ala Asp Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu 
65                  70                  75                  80  


Phe Asn Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His 
                85                  90                  95      


Thr Glu Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg 
            100                 105                 110         


Ala Ala Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala 
        115                 120                 125             


Arg Pro Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro 
    130                 135                 140                 


Ser Asp Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr 
145                 150                 155                 160 


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
                165                 170                 175     


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
            180                 185                 190         


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
        195                 200                 205             


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
    210                 215                 220                 


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
225                 230                 235                 240 


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
                245                 250                 255     


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
            260                 265                 270         


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
        275                 280                 285             


<210>  10
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthethic

<400>  10

Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro 
1               5                   10                  15      


Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu 
            20                  25                  30          


Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala 
        35                  40                  45              


Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr Ser 
    50                  55                  60                  


His Arg Val Ala Asp His Ala Gln Val Val Arg Val Leu Gly Phe Phe 
65                  70                  75                  80  


Gln Cys His Ser His Pro Ala Gln Ala Phe Asp Asp Ala Met Thr Gln 
                85                  90                  95      


Phe Gly Met Ser Arg His Gly Leu Leu Gln Leu Phe Arg Arg Val Gly 
            100                 105                 110         


Val Thr Glu Leu Glu Ala Arg Ser Gly Thr Leu Pro Pro Ala Ser Gln 
        115                 120                 125             


Arg Trp Asp Arg Ile Leu Gln Ala Ser Gly Met Lys Arg Ala Lys Pro 
    130                 135                 140                 


Ser Pro Thr Ser Thr Gln Thr Pro Asp Gln Ala Ser Leu His Ala Phe 
145                 150                 155                 160 


Ala Asp Ser Leu Glu Arg Asp Leu Asp Ala Pro Ser Pro Met His Glu 
                165                 170                 175     


Gly Asp Gln Thr Arg Ala Ser 
            180             


<210>  11
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  11

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  12
<211>  10
<212>  PRT
<213>  Simian virus 40

<400>  12

Pro Lys Lys Lys Arg Lys Val Glu Ala Ser 
1               5                   10  


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthethic

<400>  13

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  15
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  16
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  16

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  17
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  21
<211>  12
<212>  PRT
<213>  Mus sp.

<400>  21

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  22
<211>  5
<212>  PRT
<213>  Influenza virus

<400>  22

Asp Arg Leu Arg Arg 
1               5   


<210>  23
<211>  7
<212>  PRT
<213>  Influenza virus

<400>  23

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Hepatitis D virus

<400>  24

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Mus sp.

<400>  25

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  26
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  26

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  27
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


