
                                SEQUENCE LISTING

<110> Marson, Alexander
      Schmidt, Ralf
      Steinhart, Zachary
      The J. David Gladstone Institutes, a testamentary trust
          established under the Will of J. David Gladstone
      THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
      

<120> Gene activation targets for enhanced human T cell
      function

<130> 3730.183WO1

<140> PCT/US2022/012988   
<141> 2022-01-19  

<150> US 63/138,841       
<151> 2021-01-19  

<160> 165

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 508
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Ser Pro Asp Gly Pro Ser Phe Pro Ser Gly Pro Leu Ser Gly
 1               5                  10                  15
Gly Ala Ser Pro Ser Gly Asp Glu Gly Phe Phe Pro Phe Val Leu Glu
            20                  25                  30
Arg Arg Asp Ser Phe Leu Gly Gly Gly Pro Gly Pro Glu Glu Pro Glu
        35                  40                  45
Asp Leu Ala Leu Gln Leu Gln Gln Lys Glu Lys Asp Leu Leu Leu Ala
    50                  55                  60
Ala Glu Leu Gly Lys Met Leu Leu Glu Arg Asn Glu Glu Leu Arg Arg
65                  70                  75                  80
Gln Leu Glu Thr Leu Ser Ala Gln His Leu Glu Arg Glu Glu Arg Leu
                85                  90                  95
Gln Gln Glu Asn His Glu Leu Arg Arg Gly Leu Ala Ala Arg Gly Ala
            100                 105                 110
Glu Trp Glu Ala Arg Ala Val Glu Leu Glu Gly Asp Val Glu Ala Leu
        115                 120                 125
Arg Ala Gln Leu Gly Glu Gln Arg Ser Glu Gln Gln Asp Ser Gly Arg
    130                 135                 140
Glu Arg Ala Arg Ala Leu Ser Glu Leu Ser Glu Gln Asn Leu Arg Leu
145                 150                 155                 160
Ser Gln Gln Leu Ala Gln Ala Ser Gln Thr Glu Gln Glu Leu Gln Arg
                165                 170                 175
Glu Leu Asp Ala Leu Arg Gly Gln Cys Gln Ala Gln Ala Leu Ala Gly
            180                 185                 190
Ala Glu Leu Arg Thr Arg Leu Glu Ser Leu Gln Gly Glu Asn Gln Met
        195                 200                 205
Leu Gln Ser Arg Arg Gln Asp Leu Glu Ala Gln Ile Arg Gly Leu Arg
    210                 215                 220
Glu Glu Val Glu Lys Gly Glu Gly Arg Leu Gln Thr Thr His Glu Glu
225                 230                 235                 240
Leu Leu Leu Leu Arg Arg Glu Arg Arg Glu His Ser Leu Glu Leu Glu
                245                 250                 255
Arg Ala Arg Ser Glu Ala Gly Glu Ala Leu Ser Ala Leu Arg Arg Leu
            260                 265                 270
Gln Arg Arg Val Ser Glu Leu Glu Glu Glu Ser Arg Leu Gln Asp Ala
        275                 280                 285
Asp Val Ser Ala Ala Ser Leu Gln Ser Glu Leu Ala His Ser Leu Asp
    290                 295                 300
Asp Gly Asp Gln Gly Gln Gly Ala Asp Ala Pro Gly Asp Thr Pro Thr
305                 310                 315                 320
Thr Arg Ser Pro Lys Thr Arg Lys Ala Ser Ser Pro Gln Pro Ser Pro
                325                 330                 335
Pro Glu Glu Ile Leu Glu Pro Pro Lys Lys Arg Thr Ser Leu Ser Pro
            340                 345                 350
Ala Glu Ile Leu Glu Glu Lys Glu Val Glu Val Ala Lys Leu Gln Asp
        355                 360                 365
Glu Ile Ser Leu Gln Gln Ala Glu Leu Gln Ser Leu Arg Glu Glu Leu
    370                 375                 380
Gln Arg Gln Lys Glu Leu Arg Ala Gln Glu Asp Pro Gly Glu Ala Leu
385                 390                 395                 400
His Ser Ala Leu Ser Asp Arg Asp Glu Ala Val Asn Lys Ala Leu Glu
                405                 410                 415
Leu Ser Leu Gln Leu Asn Arg Val Ser Leu Glu Arg Asp Ser Leu Ser
            420                 425                 430
Arg Glu Leu Leu Arg Ala Ile Arg Gln Lys Val Ala Leu Thr Gln Glu
        435                 440                 445
Leu Glu Ala Trp Gln Asp Asp Met Gln Val Val Ile Gly Gln Gln Leu
    450                 455                 460
Arg Ser Gln Arg Gln Lys Glu Leu Ser Ala Ser Ala Ser Ser Ser Thr
465                 470                 475                 480
Pro Arg Arg Ala Ala Pro Arg Phe Ser Leu Arg Leu Gly Pro Gly Pro
                485                 490                 495
Ala Gly Gly Phe Leu Ser Asn Leu Phe Arg Arg Thr
            500                 505

<210> 2
<211> 598
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Gly Gly Gly Gly Cys Val Leu Ala Leu Gly Gly Gln Arg Gly
 1               5                  10                  15
Phe Gln Lys Glu Arg Arg Arg Met Ala Ser Gly Asn Gly Leu Pro Ser
            20                  25                  30
Ser Ser Ala Leu Val Ala Lys Gly Pro Cys Ala Leu Gly Pro Phe Pro
        35                  40                  45
Arg Tyr Ile Trp Ile His Gln Asp Thr Pro Gln Asp Ser Leu Asp Lys
    50                  55                  60
Thr Cys His Glu Ile Trp Lys Arg Val Gln Gly Leu Pro Glu Ala Ser
65                  70                  75                  80
Gln Pro Trp Thr Ser Met Glu Gln Leu Ser Val Pro Val Val Gly Thr
                85                  90                  95
Leu Arg Gly Asn Glu Leu Ser Phe Gln Glu Glu Ala Leu Glu Leu Ser
            100                 105                 110
Ser Gly Lys Asp Glu Ile Ser Leu Leu Val Glu Gln Glu Phe Leu Ser
        115                 120                 125
Leu Thr Lys Glu His Ser Ile Leu Val Glu Glu Ser Ser Gly Glu Leu
    130                 135                 140
Glu Val Pro Gly Ser Ser Pro Glu Gly Thr Arg Glu Leu Ala Pro Cys
145                 150                 155                 160
Ile Leu Ala Pro Pro Leu Val Ala Gly Ser Asn Glu Arg Pro Arg Ala
                165                 170                 175
Ser Ile Ile Val Gly Asp Lys Leu Leu Lys Gln Lys Val Ala Met Pro
            180                 185                 190
Val Ile Ser Ser Arg Gln Asp Cys Asp Ser Ala Thr Ser Thr Val Thr
        195                 200                 205
Asp Ile Leu Cys Ala Ala Glu Val Lys Ser Ser Lys Gly Thr Glu Asp
    210                 215                 220
Arg Gly Arg Ile Leu Gly Asp Ser Asn Leu Gln Val Ser Lys Leu Leu
225                 230                 235                 240
Ser Gln Phe Pro Leu Lys Ser Thr Glu Thr Ser Lys Val Pro Asp Asn
                245                 250                 255
Lys Asn Val Leu Asp Lys Thr Arg Val Thr Lys Asp Phe Leu Gln Asp
            260                 265                 270
Asn Leu Phe Ser Gly Pro Gly Pro Lys Glu Pro Thr Gly Leu Ser Pro
        275                 280                 285
Phe Leu Leu Leu Pro Pro Arg Pro Pro Pro Ala Arg Pro Asp Lys Leu
    290                 295                 300
Pro Glu Leu Pro Ala Gln Lys Arg Gln Leu Pro Val Phe Ala Lys Ile
305                 310                 315                 320
Cys Ser Lys Pro Lys Ala Asp Pro Ala Val Glu Arg His His Leu Met
                325                 330                 335
Glu Trp Ser Pro Gly Thr Lys Glu Pro Lys Lys Gly Gln Gly Ser Leu
            340                 345                 350
Phe Leu Ser Gln Trp Pro Gln Ser Gln Lys Asp Ala Cys Gly Glu Glu
        355                 360                 365
Gly Cys Cys Asp Ala Val Gly Thr Ala Ser Leu Thr Leu Pro Pro Lys
    370                 375                 380
Lys Pro Thr Cys Pro Ala Glu Lys Asn Leu Leu Tyr Glu Phe Leu Gly
385                 390                 395                 400
Ala Thr Lys Asn Pro Ser Gly Gln Pro Arg Leu Arg Asn Lys Val Glu
                405                 410                 415
Val Asp Gly Pro Glu Leu Lys Phe Asn Ala Pro Val Thr Val Ala Asp
            420                 425                 430
Lys Asn Asn Pro Lys Tyr Thr Gly Asn Val Phe Thr Pro His Phe Pro
        435                 440                 445
Thr Ala Met Thr Ser Ala Thr Leu Asn Gln Pro Leu Trp Leu Asn Leu
    450                 455                 460
Asn Tyr Pro Pro Pro Pro Val Phe Thr Asn His Ser Thr Phe Leu Gln
465                 470                 475                 480
Tyr Gln Gly Leu Tyr Pro Gln Gln Ala Ala Arg Met Pro Tyr Gln Gln
                485                 490                 495
Ala Leu His Pro Gln Leu Gly Cys Tyr Ser Gln Gln Val Met Pro Tyr
            500                 505                 510
Asn Pro Gln Gln Met Gly Gln Gln Ile Phe Arg Ser Ser Tyr Thr Pro
        515                 520                 525
Leu Leu Ser Tyr Ile Pro Phe Val Gln Pro Asn Tyr Pro Tyr Pro Gln
    530                 535                 540
Arg Thr Pro Pro Lys Met Ser Ala Asn Pro Arg Asp Pro Pro Leu Met
545                 550                 555                 560
Ala Gly Asp Gly Pro Gln Tyr Leu Phe Pro Gln Gly Tyr Gly Phe Gly
                565                 570                 575
Ser Thr Ser Gly Gly Pro Leu Met His Ser Pro Tyr Phe Ser Ser Ser
            580                 585                 590
Gly Asn Gly Ile Asn Phe
        595

<210> 3
<211> 1251
<212> PRT
<213> Homo sapiens

<400> 3
Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Thr Pro
 1               5                  10                  15
Arg Lys Thr Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu
            20                  25                  30
Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Thr
        35                  40                  45
Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val
    50                  55                  60
Ala Val Ala Asp Pro Ser Pro Gln Glu Thr Lys Glu Ala Ala Leu Thr
65                  70                  75                  80
Ser Thr Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn
                85                  90                  95
Ser Pro Ser Arg Arg Val Leu Thr Trp Leu Met Lys Gly Val Glu Lys
            100                 105                 110
Val Ile Pro Gln Pro Val His Ser Ile Thr Glu Asp Pro Ala Gln Ile
        115                 120                 125
Leu Gly His Gly Ser Thr Gly Asp Thr Gly Cys Thr Asp Glu Pro Asn
    130                 135                 140
Glu Ala Leu Glu Ala Gln Asp Thr Arg Pro Gly Leu Arg Leu Leu Leu
145                 150                 155                 160
Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser
                165                 170                 175
Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Thr Gly Ala Ala Ser
            180                 185                 190
Asp Pro Ala Pro Pro Gly Arg Pro Gln Glu Met Gly Pro Lys Leu Gln
        195                 200                 205
Ala Arg Glu Thr Pro Ser Leu Pro Thr Pro Ile Pro Leu Gln Pro Lys
    210                 215                 220
Glu Glu Pro Lys Glu Ala Pro Ala Pro Glu Pro Gln Pro Gly Ser Gln
225                 230                 235                 240
Ala Gln Thr Ser Ser Leu Pro Pro Thr Arg Asp Pro Ala Arg Leu Val
                245                 250                 255
Ala Trp Val Leu His Arg Leu Glu Met Ala Leu Pro Gln Pro Val Leu
            260                 265                 270
His Gly Lys Ile Gly Glu Gln Glu Pro Asp Ser Pro Gly Ile Cys Asp
        275                 280                 285
Val Gln Thr Ile Ser Ile Leu Pro Gly Gly Gln Val Glu Pro Asp Leu
    290                 295                 300
Val Leu Glu Glu Val Glu Pro Pro Trp Glu Asp Ala His Gln Asp Val
305                 310                 315                 320
Ser Thr Ser Pro Gln Gly Thr Glu Val Val Pro Ala Tyr Glu Glu Glu
                325                 330                 335
Asn Lys Ala Val Glu Lys Met Pro Arg Glu Leu Ser Arg Ile Glu Glu
            340                 345                 350
Glu Lys Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
        355                 360                 365
Glu Glu Glu Val Thr Glu Val Leu Leu Asp Ser Cys Val Val Ser Gln
    370                 375                 380
Val Gly Val Gly Gln Ser Glu Glu Asp Gly Thr Arg Pro Gln Ser Thr
385                 390                 395                 400
Ser Asp Gln Lys Leu Trp Glu Glu Val Gly Glu Glu Ala Lys Lys Glu
                405                 410                 415
Ala Glu Glu Lys Ala Lys Glu Glu Ala Glu Glu Val Ala Glu Glu Glu
            420                 425                 430
Ala Glu Lys Glu Pro Gln Asp Trp Ala Glu Thr Lys Glu Glu Pro Glu
        435                 440                 445
Ala Glu Ala Glu Ala Ala Ser Ser Gly Val Pro Ala Thr Lys Gln His
    450                 455                 460
Pro Glu Val Gln Val Glu Asp Thr Asp Ala Asp Ser Cys Pro Leu Met
465                 470                 475                 480
Ala Glu Glu Asn Pro Pro Ser Thr Val Leu Pro Pro Pro Ser Pro Ala
                485                 490                 495
Lys Ser Asp Thr Leu Ile Val Pro Ser Ser Ala Ser Gly Thr His Arg
            500                 505                 510
Lys Lys Leu Pro Ser Glu Asp Asp Glu Ala Glu Glu Leu Lys Ala Leu
        515                 520                 525
Ser Pro Ala Glu Ser Pro Val Val Ala Trp Ser Asp Pro Thr Thr Pro
    530                 535                 540
Lys Asp Thr Asp Gly Gln Asp Arg Ala Ala Ser Thr Ala Ser Thr Asn
545                 550                 555                 560
Ser Ala Ile Ile Asn Asp Arg Leu Gln Glu Leu Val Lys Leu Phe Lys
                565                 570                 575
Glu Arg Thr Glu Lys Val Lys Glu Lys Leu Ile Asp Pro Asp Val Thr
            580                 585                 590
Ser Asp Glu Glu Ser Pro Lys Pro Ser Pro Ala Lys Lys Ala Pro Glu
        595                 600                 605
Pro Ala Pro Asp Thr Lys Pro Ala Glu Ala Glu Pro Val Glu Glu Glu
    610                 615                 620
His Tyr Cys Asp Met Leu Cys Cys Lys Phe Lys His Arg Pro Trp Lys
625                 630                 635                 640
Lys Tyr Gln Phe Pro Gln Ser Ile Asp Pro Leu Thr Asn Leu Met Tyr
                645                 650                 655
Val Leu Trp Leu Phe Phe Val Val Met Ala Trp Asn Trp Asn Cys Trp
            660                 665                 670
Leu Ile Pro Val Arg Trp Ala Phe Pro Tyr Gln Thr Pro Asp Asn Ile
        675                 680                 685
His His Trp Leu Leu Met Asp Tyr Leu Cys Asp Leu Ile Tyr Phe Leu
    690                 695                 700
Asp Ile Thr Val Phe Gln Thr Arg Leu Gln Phe Val Arg Gly Gly Asp
705                 710                 715                 720
Ile Ile Thr Asp Lys Lys Asp Met Arg Asn Asn Tyr Leu Lys Ser Arg
                725                 730                 735
Arg Phe Lys Met Asp Leu Leu Ser Leu Leu Pro Leu Asp Phe Leu Tyr
            740                 745                 750
Leu Lys Val Gly Val Asn Pro Leu Leu Arg Leu Pro Arg Cys Leu Lys
        755                 760                 765
Tyr Met Ala Phe Phe Glu Phe Asn Ser Arg Leu Glu Ser Ile Leu Ser
    770                 775                 780
Lys Ala Tyr Val Tyr Arg Val Ile Arg Thr Thr Ala Tyr Leu Leu Tyr
785                 790                 795                 800
Ser Leu His Leu Asn Ser Cys Leu Tyr Tyr Trp Ala Ser Ala Tyr Gln
                805                 810                 815
Gly Leu Gly Ser Thr His Trp Val Tyr Asp Gly Val Gly Asn Ser Tyr
            820                 825                 830
Ile Arg Cys Tyr Tyr Phe Ala Val Lys Thr Leu Ile Thr Ile Gly Gly
        835                 840                 845
Leu Pro Asp Pro Lys Thr Leu Phe Glu Ile Val Phe Gln Leu Leu Asn
    850                 855                 860
Tyr Phe Thr Gly Val Phe Ala Phe Ser Val Met Ile Gly Gln Met Arg
865                 870                 875                 880
Asp Val Val Gly Ala Ala Thr Ala Gly Gln Thr Tyr Tyr Arg Ser Cys
                885                 890                 895
Met Asp Ser Thr Val Lys Tyr Met Asn Phe Tyr Lys Ile Pro Lys Ser
            900                 905                 910
Val Gln Asn Arg Val Lys Thr Trp Tyr Glu Tyr Thr Trp His Ser Gln
        915                 920                 925
Gly Met Leu Asp Glu Ser Glu Leu Met Val Gln Leu Pro Asp Lys Met
    930                 935                 940
Arg Leu Asp Leu Ala Ile Asp Val Asn Tyr Asn Ile Val Ser Lys Val
945                 950                 955                 960
Ala Leu Phe Gln Gly Cys Asp Arg Gln Met Ile Phe Asp Met Leu Lys
                965                 970                 975
Arg Leu Arg Ser Val Val Tyr Leu Pro Asn Asp Tyr Val Cys Lys Lys
            980                 985                 990
Gly Glu Ile Gly Arg Glu Met Tyr Ile Ile Gln Ala Gly Gln Val Gln
        995                 1000                1005
Val Leu Gly Gly Pro Asp Gly Lys Ser Val Leu Val Thr Leu Lys Ala
    1010                1015                1020
Gly Ser Val Phe Gly Glu Ile Ser Leu Leu Ala Val Gly Gly Gly Asn
1025                1030                1035                1040
Arg Arg Thr Ala Asn Val Val Ala His Gly Phe Thr Asn Leu Phe Ile
                1045                1050                1055
Leu Asp Lys Lys Asp Leu Asn Glu Ile Leu Val His Tyr Pro Glu Ser
            1060                1065                1070
Gln Lys Leu Leu Arg Lys Lys Ala Arg Arg Met Leu Arg Ser Asn Asn
        1075                1080                1085
Lys Pro Lys Glu Glu Lys Ser Val Leu Ile Leu Pro Pro Arg Ala Gly
    1090                1095                1100
Thr Pro Lys Leu Phe Asn Ala Ala Leu Ala Met Thr Gly Lys Met Gly
1105                1110                1115                1120
Gly Lys Gly Ala Lys Gly Gly Lys Leu Ala His Leu Arg Ala Arg Leu
                1125                1130                1135
Lys Glu Leu Ala Ala Leu Glu Ala Ala Ala Lys Gln Gln Glu Leu Val
            1140                1145                1150
Glu Gln Ala Lys Ser Ser Gln Asp Val Lys Gly Glu Glu Gly Ser Ala
        1155                1160                1165
Ala Pro Asp Gln His Thr His Pro Lys Glu Ala Ala Thr Asp Pro Pro
    1170                1175                1180
Ala Pro Arg Thr Pro Pro Glu Pro Pro Gly Ser Pro Pro Ser Ser Pro
1185                1190                1195                1200
Pro Pro Ala Ser Leu Gly Arg Pro Glu Gly Glu Glu Glu Gly Pro Ala
                1205                1210                1215
Glu Pro Glu Glu His Ser Val Arg Ile Cys Met Ser Pro Gly Pro Glu
            1220                1225                1230
Pro Gly Glu Gln Ile Leu Ser Val Lys Met Pro Glu Glu Arg Glu Glu
        1235                1240                1245
Lys Ala Glu
    1250

<210> 4
<211> 511
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Thr Val Gln Glu Lys Ala Ala Ala Leu Asn Leu Ser Ala Leu
 1               5                  10                  15
His Ser Pro Ala His Arg Pro Pro Gly Phe Ser Val Ala Gln Lys Pro
            20                  25                  30
Phe Gly Ala Thr Tyr Val Trp Ser Ser Ile Ile Asn Thr Leu Gln Thr
        35                  40                  45
Gln Val Glu Val Lys Lys Arg Arg His Arg Leu Lys Arg His Asn Asp
    50                  55                  60
Cys Phe Val Gly Ser Glu Ala Val Asp Val Ile Phe Ser His Leu Ile
65                  70                  75                  80
Gln Asn Lys Tyr Phe Gly Asp Val Asp Ile Pro Arg Ala Lys Val Val
                85                  90                  95
Arg Val Cys Gln Ala Leu Met Asp Tyr Lys Val Phe Glu Ala Val Pro
            100                 105                 110
Thr Lys Val Phe Gly Lys Asp Lys Lys Pro Thr Phe Glu Asp Ser Ser
        115                 120                 125
Cys Ser Leu Tyr Arg Phe Thr Thr Ile Pro Asn Gln Asp Ser Gln Leu
    130                 135                 140
Gly Lys Glu Asn Lys Leu Tyr Ser Pro Ala Arg Tyr Ala Asp Ala Leu
145                 150                 155                 160
Phe Lys Ser Ser Asp Ile Arg Ser Ala Ser Leu Glu Asp Leu Trp Glu
                165                 170                 175
Asn Leu Ser Leu Lys Pro Ala Asn Ser Pro His Val Asn Ile Ser Ala
            180                 185                 190
Thr Leu Ser Pro Gln Val Ile Asn Glu Val Trp Gln Glu Glu Thr Ile
        195                 200                 205
Gly Arg Leu Leu Gln Leu Val Asp Leu Pro Leu Leu Asp Ser Leu Leu
    210                 215                 220
Lys Gln Gln Glu Ala Val Pro Lys Ile Pro Gln Pro Lys Arg Gln Ser
225                 230                 235                 240
Thr Met Val Asn Ser Ser Asn Tyr Leu Asp Arg Gly Ile Leu Lys Ala
                245                 250                 255
Tyr Ser Asp Ser Gln Glu Asp Glu Trp Leu Ser Ala Ala Ile Asp Cys
            260                 265                 270
Leu Glu Tyr Leu Pro Asp Gln Met Val Val Glu Ile Ser Arg Ser Phe
        275                 280                 285
Pro Glu Gln Pro Asp Arg Thr Asp Leu Val Lys Glu Leu Leu Phe Asp
    290                 295                 300
Ala Ile Gly Arg Tyr Tyr Ser Ser Arg Glu Pro Leu Leu Asn His Leu
305                 310                 315                 320
Ser Asp Val His Asn Gly Ile Ala Glu Leu Leu Val Asn Gly Lys Thr
                325                 330                 335
Glu Ile Ala Leu Glu Ala Thr Gln Leu Leu Leu Lys Leu Leu Asp Phe
            340                 345                 350
Gln Asn Arg Glu Glu Phe Arg Arg Leu Leu Tyr Phe Met Ala Val Ala
        355                 360                 365
Ala Asn Pro Ser Glu Phe Lys Leu Gln Lys Glu Ser Asp Asn Arg Met
    370                 375                 380
Val Val Lys Arg Ile Phe Ser Lys Ala Ile Val Asp Asn Lys Asn Leu
385                 390                 395                 400
Ser Lys Gly Lys Thr Asp Leu Leu Val Leu Phe Leu Met Asp His Gln
                405                 410                 415
Lys Asp Val Phe Lys Ile Pro Gly Thr Leu His Lys Ile Val Ser Val
            420                 425                 430
Lys Leu Met Ala Ile Gln Asn Gly Arg Asp Pro Asn Arg Asp Ala Gly
        435                 440                 445
Tyr Ile Tyr Cys Gln Arg Ile Asp Gln Arg Asp Tyr Ser Asn Asn Thr
    450                 455                 460
Glu Lys Thr Thr Lys Asp Glu Leu Leu Asn Leu Leu Lys Thr Leu Asp
465                 470                 475                 480
Glu Asp Ser Lys Leu Ser Ala Lys Glu Lys Lys Lys Leu Leu Gly Gln
                485                 490                 495
Phe Tyr Lys Cys His Pro Asp Ile Phe Ile Glu His Phe Gly Asp
            500                 505                 510

<210> 5
<211> 279
<212> PRT
<213> Homo sapiens

<400> 5
Met Gly Leu Ser Pro Gly Ala Glu Gly Glu Tyr Ala Leu Arg Leu Pro
 1               5                  10                  15
Arg Ile Pro Pro Pro Leu Pro Lys Pro Ala Ser Arg Thr Ala Ser Thr
            20                  25                  30
Gly Pro Lys Asp Gln Pro Pro Ala Leu Arg Arg Ser Ala Val Pro His
        35                  40                  45
Ser Gly Leu Asn Ser Ile Ser Pro Leu Glu Leu Glu Glu Ser Val Gly
    50                  55                  60
Phe Ala Ala Leu Val Gln Leu Pro Ala Lys Gln Pro Pro Pro Gly Thr
65                  70                  75                  80
Leu Glu Gln Gly Arg Ser Ile Gln Gln Gly Glu Lys Ala Val Val Ser
                85                  90                  95
Leu Glu Thr Thr Pro Ser Gln Lys Ala Asp Trp Ser Ser Ile Pro Lys
            100                 105                 110
Pro Glu Asn Glu Gly Lys Leu Ile Lys Gln Ala Ala Glu Gly Lys Pro
        115                 120                 125
Arg Pro Arg Pro Gly Asp Leu Ile Glu Ile Phe Arg Ile Gly Tyr Glu
    130                 135                 140
His Trp Ala Ile Tyr Val Glu Asp Asp Cys Val Val His Leu Ala Pro
145                 150                 155                 160
Pro Ser Glu Glu Phe Glu Val Gly Ser Ile Thr Ser Ile Phe Ser Asn
                165                 170                 175
Arg Ala Val Val Lys Tyr Ser Arg Leu Glu Asp Val Leu His Gly Cys
            180                 185                 190
Ser Trp Lys Val Asn Asn Lys Leu Asp Gly Thr Tyr Leu Pro Leu Pro
        195                 200                 205
Val Asp Lys Ile Ile Gln Arg Thr Lys Lys Met Val Asn Lys Ile Val
    210                 215                 220
Gln Tyr Ser Leu Ile Glu Gly Asn Cys Glu His Phe Val Asn Gly Leu
225                 230                 235                 240
Arg Tyr Gly Val Pro Arg Ser Gln Gln Val Glu His Ala Leu Met Glu
                245                 250                 255
Gly Ala Lys Ala Ala Gly Ala Val Ile Ser Ala Val Val Asp Ser Ile
            260                 265                 270
Lys Pro Lys Pro Ile Thr Ala
        275

<210> 6
<211> 382
<212> PRT
<213> Homo sapiens

<400> 6
Met Leu Arg Trp Thr Val His Leu Glu Gly Gly Pro Arg Arg Val Asn
 1               5                  10                  15
His Ala Ala Val Ala Val Gly His Arg Val Tyr Ser Phe Gly Gly Tyr
            20                  25                  30
Cys Ser Gly Glu Asp Tyr Glu Thr Leu Arg Gln Ile Asp Val His Ile
        35                  40                  45
Phe Asn Ala Val Ser Leu Arg Trp Thr Lys Leu Pro Pro Val Lys Ser
    50                  55                  60
Ala Ile Arg Gly Gln Ala Pro Val Val Pro Tyr Met Arg Tyr Gly His
65                  70                  75                  80
Ser Thr Val Leu Ile Asp Asp Thr Val Leu Leu Trp Gly Gly Arg Asn
                85                  90                  95
Asp Thr Glu Gly Ala Cys Asn Val Leu Tyr Ala Phe Asp Val Asn Thr
            100                 105                 110
His Lys Trp Phe Thr Pro Arg Val Ser Gly Thr Val Pro Gly Ala Arg
        115                 120                 125
Asp Gly His Ser Ala Cys Val Leu Gly Lys Ile Met Tyr Ile Phe Gly
    130                 135                 140
Gly Tyr Glu Gln Gln Ala Asp Cys Phe Ser Asn Asp Ile His Lys Leu
145                 150                 155                 160
Asp Thr Ser Thr Met Thr Trp Thr Leu Ile Cys Thr Lys Gly Ser Pro
                165                 170                 175
Ala Arg Trp Arg Asp Phe His Ser Ala Thr Met Leu Gly Ser His Met
            180                 185                 190
Tyr Val Phe Gly Gly Arg Ala Asp Arg Phe Gly Pro Phe His Ser Asn
        195                 200                 205
Asn Glu Ile Tyr Cys Asn Arg Ile Arg Val Phe Asp Thr Arg Thr Glu
    210                 215                 220
Ala Trp Leu Asp Cys Pro Pro Thr Pro Val Leu Pro Glu Gly Arg Arg
225                 230                 235                 240
Ser His Ser Ala Phe Gly Tyr Asn Gly Glu Leu Tyr Ile Phe Gly Gly
                245                 250                 255
Tyr Asn Ala Arg Leu Asn Arg His Phe His Asp Leu Trp Lys Phe Asn
            260                 265                 270
Pro Val Ser Phe Thr Trp Lys Lys Ile Glu Pro Lys Gly Lys Gly Pro
        275                 280                 285
Cys Pro Arg Arg Arg Gln Cys Cys Cys Ile Val Gly Asp Lys Ile Val
    290                 295                 300
Leu Phe Gly Gly Thr Ser Pro Ser Pro Glu Glu Gly Leu Gly Asp Glu
305                 310                 315                 320
Phe Asp Leu Ile Asp His Ser Asp Leu His Ile Leu Asp Phe Ser Pro
                325                 330                 335
Ser Leu Lys Thr Leu Cys Lys Leu Ala Val Ile Gln Tyr Asn Leu Asp
            340                 345                 350
Gln Ser Cys Leu Pro His Asp Ile Arg Trp Glu Leu Asn Ala Met Thr
        355                 360                 365
Thr Asn Ser Asn Ile Ser Arg Pro Ile Val Ser Ser His Gly
    370                 375                 380

<210> 7
<211> 638
<212> PRT
<213> Homo sapiens

<400> 7
Met Val Val Ser Ala Asp Pro Leu Ser Ser Glu Arg Ala Glu Met Asn
 1               5                  10                  15
Ile Leu Glu Ile Asn Gln Glu Leu Arg Ser Gln Leu Ala Glu Ser Asn
            20                  25                  30
Gln Gln Phe Arg Asp Leu Lys Glu Lys Phe Leu Ile Thr Gln Ala Thr
        35                  40                  45
Ala Tyr Ser Leu Ala Asn Gln Leu Lys Lys Tyr Lys Cys Glu Glu Tyr
    50                  55                  60
Lys Asp Ile Ile Asp Ser Val Leu Arg Asp Glu Leu Gln Ser Met Glu
65                  70                  75                  80
Lys Leu Ala Glu Lys Leu Arg Gln Ala Glu Glu Leu Arg Gln Tyr Lys
                85                  90                  95
Ala Leu Val His Ser Gln Ala Lys Glu Leu Thr Gln Leu Arg Glu Lys
            100                 105                 110
Leu Arg Glu Gly Arg Asp Ala Ser Arg Trp Leu Asn Lys His Leu Lys
        115                 120                 125
Thr Leu Leu Thr Pro Asp Asp Pro Asp Lys Ser Gln Gly Gln Asp Leu
    130                 135                 140
Arg Glu Gln Leu Ala Glu Gly His Arg Leu Ala Glu His Leu Val His
145                 150                 155                 160
Lys Leu Ser Pro Glu Asn Asp Glu Asp Glu Asp Glu Asp Glu Asp Asp
                165                 170                 175
Lys Asp Glu Glu Val Glu Lys Val Gln Glu Ser Pro Ala Pro Arg Glu
            180                 185                 190
Val Gln Lys Thr Glu Glu Lys Glu Val Pro Gln Asp Ser Leu Glu Glu
        195                 200                 205
Cys Ala Val Thr Cys Ser Asn Ser His Asn Pro Ser Asn Ser Asn Gln
    210                 215                 220
Pro His Arg Ser Thr Lys Ile Thr Phe Lys Glu His Glu Val Asp Ser
225                 230                 235                 240
Ala Leu Val Val Glu Ser Glu His Pro His Asp Glu Glu Glu Glu Ala
                245                 250                 255
Leu Asn Ile Pro Pro Glu Asn Gln Asn Asp His Glu Glu Glu Glu Gly
            260                 265                 270
Lys Ala Pro Val Pro Pro Arg His His Asp Lys Ser Asn Ser Tyr Arg
        275                 280                 285
His Arg Glu Val Ser Phe Leu Ala Leu Asp Glu Gln Lys Val Cys Ser
    290                 295                 300
Ala Gln Asp Val Ala Arg Asp Tyr Ser Asn Pro Lys Trp Asp Glu Thr
305                 310                 315                 320
Ser Leu Gly Phe Leu Glu Lys Gln Ser Asp Leu Glu Glu Val Lys Gly
                325                 330                 335
Gln Glu Thr Val Ala Pro Arg Leu Ser Arg Gly Pro Leu Arg Val Asp
            340                 345                 350
Lys His Glu Ile Pro Gln Glu Ser Leu Asp Gly Cys Cys Leu Thr Pro
        355                 360                 365
Ser Ile Leu Pro Asp Leu Thr Pro Ser Tyr His Pro Tyr Trp Ser Thr
    370                 375                 380
Leu Tyr Ser Phe Glu Asp Lys Gln Val Ser Leu Ala Leu Val Asp Lys
385                 390                 395                 400
Ile Lys Lys Asp Gln Glu Glu Ile Glu Asp Gln Ser Pro Pro Cys Pro
                405                 410                 415
Arg Leu Ser Gln Glu Leu Pro Glu Val Lys Glu Gln Glu Val Pro Glu
            420                 425                 430
Asp Ser Val Asn Glu Val Tyr Leu Thr Pro Ser Val His His Asp Val
        435                 440                 445
Ser Asp Cys His Gln Pro Tyr Ser Ser Thr Leu Ser Ser Leu Glu Asp
    450                 455                 460
Gln Leu Ala Cys Ser Ala Leu Asp Val Ala Ser Pro Thr Glu Ala Ala
465                 470                 475                 480
Cys Pro Gln Gly Thr Trp Ser Gly Asp Leu Ser His His Arg Ser Glu
                485                 490                 495
Val Gln Ile Ser Gln Ala Gln Leu Glu Pro Ser Thr Leu Val Pro Ser
            500                 505                 510
Cys Leu Arg Leu Gln Leu Asp Gln Gly Phe His Cys Gly Asn Gly Leu
        515                 520                 525
Ala Gln Arg Gly Leu Ser Ser Thr Thr Cys Ser Phe Ser Ala Asn Ala
    530                 535                 540
Asp Ser Gly Asn Gln Trp Pro Phe Gln Glu Leu Val Leu Glu Pro Ser
545                 550                 555                 560
Leu Gly Met Lys Asn Pro Pro Gln Leu Glu Asp Asp Ala Leu Glu Gly
                565                 570                 575
Ser Ala Ser Asn Thr Gln Gly Arg Gln Val Thr Gly Arg Ile Arg Ala
            580                 585                 590
Ser Leu Val Leu Ile Leu Lys Thr Ile Arg Arg Arg Leu Pro Phe Ser
        595                 600                 605
Lys Trp Arg Leu Ala Phe Arg Phe Ala Gly Pro His Ala Glu Ser Ala
    610                 615                 620
Glu Ile Pro Asn Thr Ala Glu Arg Met Gln Arg Met Ile Gly
625                 630                 635

<210> 8
<211> 638
<212> PRT
<213> Homo sapiens

<400> 8
Met Val Val Ser Ala Asp Pro Leu Ser Ser Glu Arg Ala Glu Met Asn
 1               5                  10                  15
Ile Leu Glu Ile Asn Gln Glu Leu Arg Ser Gln Leu Ala Glu Ser Asn
            20                  25                  30
Gln Gln Phe Arg Asp Leu Lys Glu Lys Phe Leu Ile Thr Gln Ala Thr
        35                  40                  45
Ala Tyr Ser Leu Ala Asn Gln Leu Lys Lys Tyr Lys Cys Glu Glu Tyr
    50                  55                  60
Lys Asp Ile Ile Asp Ser Val Leu Arg Asp Glu Leu Gln Ser Met Glu
65                  70                  75                  80
Lys Leu Ala Glu Lys Leu Arg Gln Ala Glu Glu Leu Arg Gln Tyr Lys
                85                  90                  95
Ala Leu Val His Ser Gln Ala Lys Glu Leu Thr Gln Leu Arg Glu Lys
            100                 105                 110
Leu Arg Glu Gly Arg Asp Ala Ser Arg Trp Leu Asn Lys His Leu Lys
        115                 120                 125
Thr Leu Leu Thr Pro Asp Asp Pro Asp Lys Ser Gln Gly Gln Asp Leu
    130                 135                 140
Arg Glu Gln Leu Ala Glu Gly His Arg Leu Ala Glu His Leu Val His
145                 150                 155                 160
Lys Leu Ser Pro Glu Asn Asp Glu Asp Glu Asp Glu Asp Glu Asp Asp
                165                 170                 175
Lys Asp Glu Glu Val Glu Lys Val Gln Glu Ser Pro Ala Pro Arg Glu
            180                 185                 190
Val Gln Lys Thr Glu Glu Lys Glu Val Pro Gln Asp Ser Leu Glu Glu
        195                 200                 205
Cys Ala Val Thr Cys Ser Asn Ser His Asn Pro Ser Asn Ser Asn Gln
    210                 215                 220
Pro His Arg Ser Thr Lys Ile Thr Phe Lys Glu His Glu Val Asp Ser
225                 230                 235                 240
Ala Leu Val Val Glu Ser Glu His Pro His Asp Glu Glu Glu Glu Ala
                245                 250                 255
Leu Asn Ile Pro Pro Glu Asn Gln Asn Asp His Glu Glu Glu Glu Gly
            260                 265                 270
Lys Ala Pro Val Pro Pro Arg His His Asp Lys Ser Asn Ser Tyr Arg
        275                 280                 285
His Arg Glu Val Ser Phe Leu Ala Leu Asp Glu Gln Lys Val Cys Ser
    290                 295                 300
Ala Gln Asp Val Ala Arg Asp Tyr Ser Asn Pro Lys Trp Asp Glu Thr
305                 310                 315                 320
Ser Leu Gly Phe Leu Glu Lys Gln Ser Asp Leu Glu Glu Val Lys Gly
                325                 330                 335
Gln Glu Thr Val Ala Pro Arg Leu Ser Arg Gly Pro Leu Arg Val Asp
            340                 345                 350
Lys His Glu Ile Pro Gln Glu Ser Leu Asp Gly Cys Cys Leu Thr Pro
        355                 360                 365
Ser Ile Leu Pro Asp Leu Thr Pro Ser Tyr His Pro Tyr Trp Ser Thr
    370                 375                 380
Leu Tyr Ser Phe Glu Asp Lys Gln Val Ser Leu Ala Leu Val Asp Lys
385                 390                 395                 400
Ile Lys Lys Asp Gln Glu Glu Ile Glu Asp Gln Ser Pro Pro Cys Pro
                405                 410                 415
Arg Leu Ser Gln Glu Leu Pro Glu Val Lys Glu Gln Glu Val Pro Glu
            420                 425                 430
Asp Ser Val Asn Glu Val Tyr Leu Thr Pro Ser Val His His Asp Val
        435                 440                 445
Ser Asp Cys His Gln Pro Tyr Ser Ser Thr Leu Ser Ser Leu Glu Asp
    450                 455                 460
Gln Leu Ala Cys Ser Ala Leu Asp Val Ala Ser Pro Thr Glu Ala Ala
465                 470                 475                 480
Cys Pro Gln Gly Thr Trp Ser Gly Asp Leu Ser His His Arg Ser Glu
                485                 490                 495
Val Gln Ile Ser Gln Ala Gln Leu Glu Pro Ser Thr Leu Val Pro Ser
            500                 505                 510
Cys Leu Arg Leu Gln Leu Asp Gln Gly Phe His Cys Gly Asn Gly Leu
        515                 520                 525
Ala Gln Arg Gly Leu Ser Ser Thr Thr Cys Ser Phe Ser Ala Asn Ala
    530                 535                 540
Asp Ser Gly Asn Gln Trp Pro Phe Gln Glu Leu Val Leu Glu Pro Ser
545                 550                 555                 560
Leu Gly Met Lys Asn Pro Pro Gln Leu Glu Asp Asp Ala Leu Glu Gly
                565                 570                 575
Ser Ala Ser Asn Thr Gln Gly Arg Gln Val Thr Gly Arg Ile Arg Ala
            580                 585                 590
Ser Leu Val Leu Ile Leu Lys Thr Ile Arg Arg Arg Leu Pro Phe Ser
        595                 600                 605
Lys Trp Arg Leu Ala Phe Arg Phe Ala Gly Pro His Ala Glu Ser Ala
    610                 615                 620
Glu Ile Pro Asn Thr Ala Glu Arg Met Gln Arg Met Ile Gly
625                 630                 635

<210> 9
<211> 300
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Glu Glu Ala Ser Ser Pro Gly Leu Gly Cys Ser Lys Pro His
 1               5                  10                  15
Leu Glu Lys Leu Thr Leu Gly Ile Thr Arg Ile Leu Glu Ser Ser Pro
            20                  25                  30
Gly Val Thr Glu Val Thr Ile Ile Glu Lys Pro Pro Ala Glu Arg His
        35                  40                  45
Met Ile Ser Ser Trp Glu Gln Lys Asn Asn Cys Val Met Pro Glu Asp
    50                  55                  60
Val Lys Asn Phe Tyr Leu Met Thr Asn Gly Phe His Met Thr Trp Ser
65                  70                  75                  80
Val Lys Leu Asp Glu His Ile Ile Pro Leu Gly Ser Met Ala Ile Asn
                85                  90                  95
Ser Ile Ser Lys Leu Thr Gln Leu Thr Gln Ser Ser Met Tyr Ser Leu
            100                 105                 110
Pro Asn Ala Pro Thr Leu Ala Asp Leu Glu Asp Asp Thr His Glu Ala
        115                 120                 125
Ser Asp Asp Gln Pro Glu Lys Pro His Phe Asp Ser Arg Ser Val Ile
    130                 135                 140
Phe Glu Leu Asp Ser Cys Asn Gly Ser Gly Lys Val Cys Leu Val Tyr
145                 150                 155                 160
Lys Ser Gly Lys Pro Ala Leu Ala Glu Asp Thr Glu Ile Trp Phe Leu
                165                 170                 175
Asp Arg Ala Leu Tyr Trp His Phe Leu Thr Asp Thr Phe Thr Ala Tyr
            180                 185                 190
Tyr Arg Leu Leu Ile Thr His Leu Gly Leu Pro Gln Trp Gln Tyr Ala
        195                 200                 205
Phe Thr Ser Tyr Gly Ile Ser Pro Gln Ala Lys Gln Trp Phe Ser Met
    210                 215                 220
Tyr Lys Pro Ile Thr Tyr Asn Thr Asn Leu Leu Thr Glu Glu Thr Asp
225                 230                 235                 240
Ser Phe Val Asn Lys Leu Asp Pro Ser Lys Val Phe Lys Ser Lys Asn
                245                 250                 255
Lys Ile Val Ile Pro Lys Lys Lys Gly Pro Val Gln Pro Ala Gly Gly
            260                 265                 270
Gln Lys Gly Pro Ser Gly Pro Ser Gly Pro Ser Thr Ser Ser Thr Ser
        275                 280                 285
Lys Ser Ser Ser Gly Ser Gly Asn Pro Thr Arg Lys
    290                 295                 300

<210> 10
<211> 657
<212> PRT
<213> Homo sapiens

<400> 10
Met Ile Glu Ser Gln Glu Pro Val Thr Phe Glu Asp Val Ala Val Asp
 1               5                  10                  15
Phe Thr Gln Glu Glu Trp Gln Gln Leu Asn Pro Ala Gln Lys Thr Leu
            20                  25                  30
His Arg Asp Val Met Leu Glu Thr Tyr Asn His Leu Val Ser Val Gly
        35                  40                  45
Cys Ser Gly Ile Lys Pro Asp Val Ile Phe Lys Leu Glu His Gly Lys
    50                  55                  60
Asp Pro Trp Ile Ile Glu Ser Glu Leu Ser Arg Trp Ile Tyr Pro Asp
65                  70                  75                  80
Arg Val Lys Gly Leu Glu Ser Ser Gln Gln Ile Ile Ser Gly Glu Leu
                85                  90                  95
Leu Phe Gln Arg Glu Ile Leu Glu Arg Ala Pro Lys Asp Asn Ser Leu
            100                 105                 110
Tyr Ser Val Leu Lys Ile Trp His Ile Asp Asn Gln Met Asp Arg Tyr
        115                 120                 125
Gln Gly Asn Gln Asp Arg Val Leu Arg Gln Val Thr Val Ile Ser Arg
    130                 135                 140
Glu Thr Leu Thr Asp Glu Met Gly Ser Lys Tyr Ser Ala Phe Gly Lys
145                 150                 155                 160
Met Phe Asn Arg Cys Thr Asp Leu Ala Pro Leu Ser Gln Lys Phe His
                165                 170                 175
Lys Phe Asp Ser Cys Glu Asn Ser Leu Lys Ser Asn Ser Asp Leu Leu
            180                 185                 190
Asn Tyr Asn Arg Ser Tyr Ala Arg Lys Asn Pro Thr Lys Arg Phe Arg
        195                 200                 205
Cys Gly Arg Pro Pro Lys Tyr Asn Ala Ser Cys Ser Val Pro Glu Lys
    210                 215                 220
Glu Gly Phe Ile His Thr Gly Met Glu Pro Tyr Gly Asp Ser Gln Cys
225                 230                 235                 240
Glu Lys Val Leu Ser His Lys Gln Ala His Val Gln Tyr Lys Lys Phe
                245                 250                 255
Gln Ala Arg Glu Lys Pro Asn Val Cys Ser Met Cys Gly Lys Ala Phe
            260                 265                 270
Ile Lys Lys Ser Gln Leu Ile Ile His Gln Arg Ile His Thr Gly Glu
        275                 280                 285
Lys Pro Tyr Val Cys Gly Asp Cys Arg Lys Ala Phe Ser Glu Lys Ser
    290                 295                 300
His Leu Ile Val His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
305                 310                 315                 320
Cys Thr Lys Tyr Gly Arg Ala Phe Ser Arg Lys Ser Pro Phe Thr Val
                325                 330                 335
His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Phe Glu Cys
            340                 345                 350
Pro Lys Ala Phe Ser Gln Lys Ser His Leu Ile Ile His Gln Arg Val
        355                 360                 365
His Thr Arg Glu Lys Pro Phe Glu Cys Ser Glu Cys Arg Lys Ala Phe
    370                 375                 380
Cys Glu Met Ser His Leu Phe Ile His Gln Ile Thr His Thr Gly Lys
385                 390                 395                 400
Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Thr Phe Pro Arg Lys Thr
                405                 410                 415
Gln Leu Ile Ile His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys
            420                 425                 430
Cys Gly Glu Cys Gly Lys Thr Phe Cys Gln Gln Ser His Leu Ile Gly
        435                 440                 445
His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Thr Asp Cys
    450                 455                 460
Gly Lys Ala Phe Ser Gln Lys Ser His Leu Thr Gly His Gln Arg Leu
465                 470                 475                 480
His Thr Gly Glu Lys Pro Tyr Met Cys Thr Glu Cys Gly Lys Ser Phe
                485                 490                 495
Ser Gln Lys Ser Pro Leu Ile Ile His Gln Arg Ile His Thr Gly Glu
            500                 505                 510
Lys Pro Tyr Gln Cys Gly Glu Cys Gly Lys Thr Phe Ser Gln Lys Ser
        515                 520                 525
Leu Leu Ile Ile His Leu Arg Val His Thr Gly Glu Lys Pro Tyr Glu
    530                 535                 540
Cys Thr Glu Cys Gly Arg Ala Phe Ser Leu Lys Ser His Leu Ile Leu
545                 550                 555                 560
His Gln Arg Gly His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys
                565                 570                 575
Gly Lys Ala Phe Cys Gly Lys Ser Pro Leu Ile Ile His Gln Lys Thr
            580                 585                 590
His Pro Arg Glu Lys Thr Pro Glu Cys Ala Glu Ser Gly Met Thr Phe
        595                 600                 605
Phe Trp Lys Ser Gln Met Ile Thr Tyr Gln Arg Arg His Thr Gly Glu
    610                 615                 620
Lys Pro Ser Arg Cys Ser Asp Cys Gly Lys Ala Phe Cys Gln His Val
625                 630                 635                 640
Tyr Phe Thr Gly His Gln Asn Pro Tyr Arg Lys Asp Thr Leu Tyr Ile
                645                 650                 655
Cys


<210> 11
<211> 904
<212> PRT
<213> Homo sapiens

<400> 11
Met Leu Glu Thr Tyr Asn Ser Leu Val Ser Leu Gln Glu Leu Val Ser
 1               5                  10                  15
Phe Glu Glu Val Ala Val His Phe Thr Trp Glu Glu Trp Gln Asp Leu
            20                  25                  30
Asp Asp Ala Gln Arg Thr Leu Tyr Arg Asp Val Met Leu Glu Thr Tyr
        35                  40                  45
Ser Ser Leu Val Ser Leu Gly His Cys Ile Thr Lys Pro Glu Met Ile
    50                  55                  60
Phe Lys Leu Glu Gln Gly Ala Glu Pro Trp Ile Val Glu Glu Thr Pro
65                  70                  75                  80
Asn Leu Arg Leu Ser Ala Val Gln Ile Ile Asp Asp Leu Ile Glu Arg
                85                  90                  95
Ser His Glu Ser His Asp Arg Phe Phe Trp Gln Ile Val Ile Thr Asn
            100                 105                 110
Ser Asn Thr Ser Thr Gln Glu Arg Val Glu Leu Gly Lys Thr Phe Asn
        115                 120                 125
Leu Asn Ser Asn His Val Leu Asn Leu Ile Ile Asn Asn Gly Asn Ser
    130                 135                 140
Ser Gly Met Lys Pro Gly Gln Phe Asn Asp Cys Gln Asn Met Leu Phe
145                 150                 155                 160
Pro Ile Lys Pro Gly Glu Thr Gln Ser Gly Glu Lys Pro His Val Cys
                165                 170                 175
Asp Ile Thr Arg Arg Ser His Arg His His Glu His Leu Thr Gln His
            180                 185                 190
His Lys Ile Gln Thr Leu Leu Gln Thr Phe Gln Cys Asn Glu Gln Gly
        195                 200                 205
Lys Thr Phe Asn Thr Glu Ala Met Phe Phe Ile His Lys Arg Val His
    210                 215                 220
Ile Val Gln Thr Phe Gly Lys Tyr Asn Glu Tyr Glu Lys Ala Cys Asn
225                 230                 235                 240
Asn Ser Ala Val Ile Val Gln Val Ile Thr Gln Val Gly Gln Pro Thr
                245                 250                 255
Cys Cys Arg Lys Ser Asp Phe Thr Lys His Gln Gln Thr His Thr Gly
            260                 265                 270
Glu Lys Pro Tyr Glu Cys Val Glu Cys Glu Lys Pro Ser Ile Ser Lys
        275                 280                 285
Ser Asp Leu Met Leu Gln Cys Lys Met Pro Thr Glu Glu Lys Pro Tyr
    290                 295                 300
Ala Cys Asn Trp Cys Glu Lys Leu Phe Ser Tyr Lys Ser Ser Leu Ile
305                 310                 315                 320
Ile His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Gly Cys Asn Glu
                325                 330                 335
Cys Gly Lys Thr Phe Arg Arg Lys Ser Phe Leu Thr Leu His Glu Arg
            340                 345                 350
Thr His Thr Gly Asp Lys Pro Tyr Lys Cys Ile Glu Cys Gly Lys Thr
        355                 360                 365
Phe His Cys Lys Ser Leu Leu Thr Leu His His Arg Thr His Ser Gly
    370                 375                 380
Glu Lys Pro Tyr Gln Cys Ser Glu Cys Gly Lys Thr Phe Ser Gln Lys
385                 390                 395                 400
Ser Tyr Leu Thr Ile His His Arg Thr His Thr Gly Glu Lys Pro Tyr
                405                 410                 415
Ala Cys Asp His Cys Glu Glu Ala Phe Ser His Lys Ser Arg Leu Thr
            420                 425                 430
Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu
        435                 440                 445
Cys Gly Lys Pro Phe Ile Asn Lys Ser Asn Leu Arg Leu His Gln Arg
    450                 455                 460
Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr
465                 470                 475                 480
Phe His Arg Lys Ser Phe Leu Thr Ile His Gln Trp Thr His Thr Gly
                485                 490                 495
Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Arg Cys Lys
            500                 505                 510
Ser Phe Leu Thr Val His Gln Arg Thr His Ala Gly Glu Lys Pro Tyr
        515                 520                 525
Ala Cys Asn Glu Cys Gly Lys Thr Tyr Ser His Lys Ser Tyr Leu Thr
    530                 535                 540
Val His His Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu
545                 550                 555                 560
Cys Gly Lys Ser Phe His Cys Lys Ser Phe Leu Thr Ile His Gln Arg
                565                 570                 575
Thr His Ala Gly Lys Lys Pro Tyr Glu Cys Asn Glu Cys Glu Lys Thr
            580                 585                 590
Phe Ile Asn Lys Leu Asn Leu Gly Ile His Lys Ile Thr His Thr Gly
        595                 600                 605
Glu Arg Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Arg Gln Lys
    610                 615                 620
Ser Asn Leu Ser Thr His Gln Gly Thr His Thr Gly Glu Lys Pro Tyr
625                 630                 635                 640
Val Cys Gly Lys Thr Phe His Arg Lys Ser Phe Leu Thr Ile His Gln
                645                 650                 655
Arg Thr His Thr Gly Lys Asn Arg Met Asp Val Met Asn Val Glu Lys
            660                 665                 670
Leu Phe Val Arg Asn His Thr Leu Leu Tyr Ile Arg Glu Leu Thr Pro
        675                 680                 685
Gly Lys Ser Pro Met Asn Val Met Asn Val Glu Asn Pro Phe Ile Arg
    690                 695                 700
Arg Gln Ile Phe Arg Ser Ile Lys Val Phe Thr Arg Gly Arg Asn Pro
705                 710                 715                 720
Met Asn Val Ala Asn Val Glu Lys Pro Cys Gln Lys Ser Val Leu Thr
                725                 730                 735
Val His His Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu
            740                 745                 750
Cys Gly Lys Thr Phe Cys His Lys Ser Asn Leu Ser Thr His Gln Gly
        755                 760                 765
Thr His Ser Gly Glu Lys Pro Tyr Glu Cys Asp Glu Cys Arg Lys Thr
    770                 775                 780
Phe Tyr Asp Lys Thr Val Leu Thr Ile His Gln Arg Thr His Thr Gly
785                 790                 795                 800
Glu Lys Pro Phe Glu Cys Lys Glu Cys Arg Lys Thr Phe Ser Gln Lys
                805                 810                 815
Ser Lys Leu Phe Val His His Arg Thr His Thr Gly Glu Lys Pro Phe
            820                 825                 830
Arg Cys Asn Glu Cys Arg Lys Thr Phe Ser Gln Lys Ser Gly Leu Ser
        835                 840                 845
Ile His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu
    850                 855                 860
Cys Gly Lys Thr Phe Cys Gln Lys Ser His Leu Ser Arg His Gln Gln
865                 870                 875                 880
Thr His Ile Gly Glu Lys Ser Asp Val Ala Glu Ala Gly Tyr Val Phe
                885                 890                 895
Pro Gln Asn His Ser Phe Phe Pro
            900

<210> 12
<211> 930
<212> PRT
<213> Homo sapiens

<400> 12
Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro
 1               5                  10                  15
Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly
            20                  25                  30
Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly
        35                  40                  45
Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu
    50                  55                  60
Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu
65                  70                  75                  80
Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg
                85                  90                  95
Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly
            100                 105                 110
Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser
        115                 120                 125
His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala
    130                 135                 140
Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His
145                 150                 155                 160
Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu
                165                 170                 175
Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val
            180                 185                 190
Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser
        195                 200                 205
Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala
    210                 215                 220
His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp
225                 230                 235                 240
Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp
                245                 250                 255
Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu
            260                 265                 270
Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln
        275                 280                 285
His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His
    290                 295                 300
Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val
305                 310                 315                 320
Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr
                325                 330                 335
Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly
            340                 345                 350
Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu
        355                 360                 365
Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val
    370                 375                 380
Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp
385                 390                 395                 400
Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu
                405                 410                 415
Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser
            420                 425                 430
Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala
        435                 440                 445
Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu
    450                 455                 460
Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile
465                 470                 475                 480
Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln
                485                 490                 495
Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp
            500                 505                 510
Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val
        515                 520                 525
Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys
    530                 535                 540
Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys
545                 550                 555                 560
Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp
                565                 570                 575
Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg
            580                 585                 590
His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly
        595                 600                 605
Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn
    610                 615                 620
Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln
625                 630                 635                 640
Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr
                645                 650                 655
Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys
            660                 665                 670
Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr
        675                 680                 685
Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val
    690                 695                 700
Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys
705                 710                 715                 720
Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly
                725                 730                 735
Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro
            740                 745                 750
Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln
        755                 760                 765
Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr
    770                 775                 780
Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp
785                 790                 795                 800
Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp
                805                 810                 815
Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val
            820                 825                 830
Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser
        835                 840                 845
Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser
    850                 855                 860
His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val
865                 870                 875                 880
Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His
                885                 890                 895
Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly
            900                 905                 910
Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys
        915                 920                 925
Lys Cys
    930

<210> 13
<211> 2025
<212> DNA
<213> Homo sapiens

<400> 13
agagcgagaa gatgatgcat gtgagccctg cccttgggaa gcttccaggt tgggaaatga      60
ggaatgagcc tgacacccag ggcccagaga gacccaggac agaggcaggt caggaggcag     120
acacgcgctg ctgggtaatg acgacagcac cagtaatcac ggctactcct tgttaagtac     180
ttactaagtg caagactcca agctaagcaa ttaatagacc ttttcttgtt taatccttac     240
cacaattcca tagggttgag taggaagtcc ttcttgaagt ctaatctcaa gaattcatgc     300
catggattgg gccaatgttc cacctttatt ggagtctggg gacttaggtg gaaaaggcag     360
aactggctgg ttggaggagc cacctccctg caaggggcca ggagggagat tacggaggcg     420
ccaagcccag agctccaaca tgcacctgcc acagctccag gggagatcgg gggcctgcca     480
atttaccccg ccccatgatc tcatggctgt gtgcgccagg cactggctca gggagcagca     540
tctcacagag aagatacttg gatgggccac aggccaaaac tgggccaaaa ccctggagag     600
ggggacctgg ctcaaggcca caccacattt ccatgtcatt ttccagtggc accaactgag     660
ctggacagat gttctcacag agctacacat gccacagtca tcactagttg cgagagtctc     720
cagtgttcat taagcctatt ttgctggaag tttagtccct ggaggattag tccctgccct     780
taaggagtgc caaagaagac tttggaatct aagtcacatc tcccctgctg caattttttc     840
ctcttgataa tcaaggaatc tcactgataa aactctcaat gaggagcagc tctccccatg     900
agcaagttct tgccttcatt gccagggagg ccccagctaa ggttatactg ggaaaggaat     960
ctctggggag tacctggaag aggtcagctt ctcctcaaag gaagcctctc cagctggtgt    1020
actgcaaagc cttccaagac caagttccct cttcctggcc tctggaacca gcctgtgtgc    1080
cagcgctgtg tccccagtaa cacacatgag tctctccctc agaagccaca gaaggatgca    1140
gagagagacc aacccaggat tgattctcag cacttactaa ttgtgtggac ataactgctc    1200
tggacctcag ctttgctatc tataaaatga gcaccctttt tatagatatg aacactttaa    1260
gagagtcata aagattgaag ttgatttgtg ctgcgcctgg cacagaggtc tccctcagta    1320
aatggcagcc actgctattg gggtgcccca acaccccttg cccctgccca ccattagctt    1380
tcacttaggc ccacactgag ggtgtggctg ttgtgttggg ggaaggaaaa aaaccatgcc    1440
tgggttgcag ggcccccacc accaactggt ctgcttttgt gggaagcatt ttctgatgcc    1500
ctcgccctac ccgtgggctg gttgactaag tgtccagcat catgaggaaa agagcagggt    1560
tcagggacag cttggctcag ccctgaaact catctgggcc taggtccaga tgagaggcaa    1620
gcctgggagg ccttccgttg tacccttgcc tatcctgcag caccctctag cctgcaggcc    1680
gctcctgggt ggcatagcac cttggatgtc aggtgtgggc cttcccaggc acatggcatg    1740
agggggcact tctgtgggtt gttgggggca ggaagggatg tgtctccagc tggacttggg    1800
ctctcgcatt ttggggccca gccatgccag gacagcacac atgggcgctt agtgcgaatc    1860
tcatgatgga gcagaggagg agcaaagcaa aaccagggag tccccaggcc cctgcttctg    1920
ccccgcccag agacagtgga gcaggtgtct ccagcttctt aacctcaacg cacagtaaga    1980
aatacatttt acagcaacca atagacacat acatttacaa aacga                    2025

<210> 14
<211> 534
<212> PRT
<213> Homo sapiens

<400> 14
Met Arg Arg His Ser Glu Thr Asp Val Glu Glu Gln Thr Gln Glu Leu
 1               5                  10                  15
Lys Thr Ile Thr Gln Leu Gln Glu Gln Cys Arg Ala Leu Gln Ile Gln
            20                  25                  30
Gly Val Lys Glu Asn Met Asp Gln Asn Lys Ala Thr Leu Ala Leu Leu
        35                  40                  45
Arg Ser Asn Ile Arg Arg Gly Ala Gln Asp Trp Ala Leu Ala Lys Lys
    50                  55                  60
Tyr Asp Gln Trp Thr Ile Ser Lys Ala Cys Gly Lys Asn Leu Pro Leu
65                  70                  75                  80
Arg Leu Ala His Cys Arg Ser Thr Met Glu Val Val Arg Glu Lys Leu
                85                  90                  95
Arg Lys Tyr Val Phe Asp Arg Val Asn Met His Asn Leu Leu Ile His
            100                 105                 110
Leu Val Arg Arg Arg Gly Gln Lys Leu Glu Ser Met Gln Leu Glu Leu
        115                 120                 125
Asp Ser Leu Arg Ser Gln Pro Asp Ala Ser Lys Glu Glu Leu Arg Leu
    130                 135                 140
Leu Gln Ile Ile Arg Gln Leu Glu Asn Asn Ile Glu Lys Thr Met Ile
145                 150                 155                 160
Lys Ile Ile Thr Ser Gln Asn Ile His Leu Leu Tyr Leu Asp Leu Leu
                165                 170                 175
Asp Tyr Leu Lys Thr Val Leu Ala Gly Tyr Pro Ile Glu Leu Asp Lys
            180                 185                 190
Leu Gln Asn Leu Val Val Asn Tyr Cys Ser Glu Leu Ser Asp Met Lys
        195                 200                 205
Ile Met Ser Gln Asp Ala Met Met Ile Thr Asp Glu Val Lys Arg Asn
    210                 215                 220
Met Arg Gln Arg Glu Ala Ser Phe Ile Glu Glu Arg Arg Ala Arg Glu
225                 230                 235                 240
Asn Arg Leu Asn Gln Gln Lys Lys Leu Ile Asp Lys Ile His Thr Lys
                245                 250                 255
Glu Thr Ser Glu Lys Tyr Arg Arg Gly Gln Met Asp Leu Asp Phe Pro
            260                 265                 270
Ser Asn Leu Met Ser Thr Glu Thr Leu Lys Leu Arg Arg Lys Glu Thr
        275                 280                 285
Ser Thr Ala Glu Met Glu Tyr Gln Ser Gly Val Thr Ala Val Val Glu
    290                 295                 300
Lys Val Lys Ser Ala Val Arg Cys Ser His Val Trp Asp Ile Thr Ser
305                 310                 315                 320
Arg Phe Leu Ala Gln Arg Asn Thr Glu Glu Asn Leu Glu Leu Gln Met
                325                 330                 335
Glu Asp Cys Glu Glu Trp Arg Val Gln Leu Lys Ala Leu Val Lys Gln
            340                 345                 350
Leu Glu Leu Glu Glu Ala Val Leu Lys Phe Arg Gln Lys Pro Ser Ser
        355                 360                 365
Ile Ser Phe Lys Ser Val Glu Lys Lys Met Thr Asp Met Leu Lys Glu
    370                 375                 380
Glu Glu Glu Arg Leu Gln Leu Ala His Ser Asn Met Thr Lys Gly Gln
385                 390                 395                 400
Glu Leu Leu Leu Thr Ile Gln Met Gly Ile Asp Asn Leu Tyr Val Arg
                405                 410                 415
Leu Met Gly Ile Asn Leu Pro Ala Thr Gln Arg Glu Val Val Leu Ser
            420                 425                 430
Asn Thr Leu Asp Leu Asn Ser Lys Leu Ala Tyr Cys Glu Gly Lys Leu
        435                 440                 445
Thr Tyr Leu Ala Asp Arg Val Gln Met Val Ser Arg Thr Glu Glu Gly
    450                 455                 460
Asp Thr Lys Val Arg Asp Thr Leu Glu Ser Ser Thr Leu Met Glu Lys
465                 470                 475                 480
Tyr Asn Thr Arg Ile Ser Phe Glu Asn Arg Glu Glu Asp Met Ile Asp
                485                 490                 495
Thr Phe Gln Phe Pro Asp Met Asp His Ser Tyr Val Pro Ser Arg Ala
            500                 505                 510
Glu Ile Lys Arg Gln Ala Gln Arg Leu Ile Glu Gly Lys Leu Lys Ala
        515                 520                 525
Ala Lys Lys Lys Lys Lys
    530

<210> 15
<211> 399
<212> PRT
<213> Homo sapiens

<400> 15
Met Glu Arg Lys Asn Pro Ser Arg Glu Ser Pro Arg Arg Leu Ser Ala
 1               5                  10                  15
Lys Val Gly Lys Gly Thr Glu Met Lys Lys Val Ala Arg Gln Leu Gly
            20                  25                  30
Met Ala Ala Ala Glu Ser Asp Lys Asp Ser Gly Phe Ser Asp Gly Ser
        35                  40                  45
Ser Glu Cys Leu Ser Ser Ala Glu Gln Met Glu Ser Glu Asp Met Leu
    50                  55                  60
Ser Ala Leu Gly Trp Ser Arg Glu Asp Arg Pro Arg Gln Asn Ser Lys
65                  70                  75                  80
Thr Ala Lys Asn Ala Phe Pro Thr Leu Ser Pro Met Val Val Met Lys
                85                  90                  95
Asn Val Leu Val Lys Gln Gly Ser Ser Ser Ser Gln Leu Gln Ser Trp
            100                 105                 110
Thr Val Gln Pro Ser Phe Glu Val Ile Ser Ala Gln Pro Gln Leu Leu
        115                 120                 125
Phe Leu His Pro Pro Val Pro Ser Pro Val Ser Pro Cys His Thr Gly
    130                 135                 140
Glu Lys Lys Ser Asp Ser Arg Asn Tyr Leu Pro Ile Leu Asn Ser Tyr
145                 150                 155                 160
Thr Lys Ile Ala Pro His Pro Gly Lys Arg Gly Leu Ser Leu Gly Pro
                165                 170                 175
Glu Glu Lys Gly Thr Ser Gly Val Gln Lys Lys Ile Cys Thr Glu Arg
            180                 185                 190
Leu Gly Pro Ser Leu Ser Ser Ser Glu Pro Thr Lys Ala Gly Ala Val
        195                 200                 205
Pro Ser Ser Pro Ser Thr Pro Ala Pro Pro Ser Ala Lys Leu Ala Glu
    210                 215                 220
Asp Ser Ala Leu Gln Gly Val Pro Ser Leu Val Ala Gly Gly Ser Pro
225                 230                 235                 240
Gln Thr Leu Gln Pro Val Ser Ser Ser His Val Ala Lys Ala Pro Ser
                245                 250                 255
Leu Thr Phe Ala Ser Pro Ala Ser Pro Val Cys Ala Ser Asp Ser Thr
            260                 265                 270
Leu His Gly Leu Glu Ser Asn Ser Pro Leu Ser Pro Leu Ser Ala Asn
        275                 280                 285
Tyr Ser Ser Pro Leu Trp Ala Ala Glu His Leu Cys Arg Ser Pro Asp
    290                 295                 300
Ile Phe Ser Glu Gln Arg Gln Ser Lys His Arg Arg Phe Gln Asn Thr
305                 310                 315                 320
Leu Val Val Leu His Lys Ser Gly Leu Leu Glu Ile Thr Leu Lys Thr
                325                 330                 335
Lys Glu Leu Ile Arg Gln Asn Gln Ala Thr Gln Val Glu Leu Asp Gln
            340                 345                 350
Leu Lys Glu Gln Thr Gln Leu Phe Ile Glu Ala Thr Lys Ser Arg Ala
        355                 360                 365
Pro Gln Ala Trp Ala Lys Leu Gln Ala Ser Leu Thr Pro Gly Ser Ser
    370                 375                 380
Asn Thr Gly Ser Asp Leu Glu Ala Phe Ser Asp His Pro Ala Ile
385                 390                 395

<210> 16
<211> 768
<212> PRT
<213> Homo sapiens

<400> 16
Met Ser Asn Leu Ser Lys Gly Thr Gly Ser Arg Lys Asp Thr Lys Met
 1               5                  10                  15
Arg Ile Arg Ala Phe Pro Met Thr Met Asp Glu Lys Tyr Val Asn Ser
            20                  25                  30
Ile Trp Asp Leu Leu Lys Asn Ala Ile Gln Glu Ile Gln Arg Lys Asn
        35                  40                  45
Asn Ser Gly Leu Ser Phe Glu Glu Leu Tyr Arg Asn Ala Tyr Thr Met
    50                  55                  60
Val Leu His Lys His Gly Glu Lys Leu Tyr Thr Gly Leu Arg Glu Val
65                  70                  75                  80
Val Thr Glu His Leu Ile Asn Lys Val Arg Glu Asp Val Leu Asn Ser
                85                  90                  95
Leu Asn Asn Asn Phe Leu Gln Thr Leu Asn Gln Ala Trp Asn Asp His
            100                 105                 110
Gln Thr Ala Met Val Met Ile Arg Asp Ile Leu Met Tyr Met Asp Arg
        115                 120                 125
Val Tyr Val Gln Gln Asn Asn Val Glu Asn Val Tyr Asn Leu Gly Leu
    130                 135                 140
Ile Ile Phe Arg Asp Gln Val Val Arg Tyr Gly Cys Ile Arg Asp His
145                 150                 155                 160
Leu Arg Gln Thr Leu Leu Asp Met Ile Ala Arg Glu Arg Lys Gly Glu
                165                 170                 175
Val Val Asp Arg Gly Ala Ile Arg Asn Ala Cys Gln Met Leu Met Ile
            180                 185                 190
Leu Gly Leu Glu Gly Arg Ser Val Tyr Glu Glu Asp Phe Glu Ala Pro
        195                 200                 205
Phe Leu Glu Met Ser Ala Glu Phe Phe Gln Met Glu Ser Gln Lys Phe
    210                 215                 220
Leu Ala Glu Asn Ser Ala Ser Val Tyr Ile Lys Lys Val Glu Ala Arg
225                 230                 235                 240
Ile Asn Glu Glu Ile Glu Arg Val Met His Cys Leu Asp Lys Ser Thr
                245                 250                 255
Glu Glu Pro Ile Val Lys Val Val Glu Arg Glu Leu Ile Ser Lys His
            260                 265                 270
Met Lys Thr Ile Val Glu Met Glu Asn Ser Gly Leu Val His Met Leu
        275                 280                 285
Lys Asn Gly Lys Thr Glu Asp Leu Gly Cys Met Tyr Lys Leu Phe Ser
    290                 295                 300
Arg Val Pro Asn Gly Leu Lys Thr Met Cys Glu Cys Met Ser Ser Tyr
305                 310                 315                 320
Leu Arg Glu Gln Gly Lys Ala Leu Val Ser Glu Glu Gly Glu Gly Lys
                325                 330                 335
Asn Pro Val Asp Tyr Ile Gln Gly Leu Leu Asp Leu Lys Ser Arg Phe
            340                 345                 350
Asp Arg Phe Leu Leu Glu Ser Phe Asn Asn Asp Arg Leu Phe Lys Gln
        355                 360                 365
Thr Ile Ala Gly Asp Phe Glu Tyr Phe Leu Asn Leu Asn Ser Arg Ser
    370                 375                 380
Pro Glu Tyr Leu Ser Leu Phe Ile Asp Asp Lys Leu Lys Lys Gly Val
385                 390                 395                 400
Lys Gly Leu Thr Glu Gln Glu Val Glu Thr Ile Leu Asp Lys Ala Met
                405                 410                 415
Val Leu Phe Arg Phe Met Gln Glu Lys Asp Val Phe Glu Arg Tyr Tyr
            420                 425                 430
Lys Gln His Leu Ala Arg Arg Leu Leu Thr Asn Lys Ser Val Ser Asp
        435                 440                 445
Asp Ser Glu Lys Asn Met Ile Ser Lys Leu Lys Thr Glu Cys Gly Cys
    450                 455                 460
Gln Phe Thr Ser Lys Leu Glu Gly Met Phe Arg Asp Met Ser Ile Ser
465                 470                 475                 480
Asn Thr Thr Met Asp Glu Phe Arg Gln His Leu Gln Ala Thr Gly Val
                485                 490                 495
Ser Leu Gly Gly Val Asp Leu Thr Val Arg Val Leu Thr Thr Gly Tyr
            500                 505                 510
Trp Pro Thr Gln Ser Ala Thr Pro Lys Cys Asn Ile Pro Pro Ala Pro
        515                 520                 525
Arg His Ala Phe Glu Ile Phe Arg Arg Phe Tyr Leu Ala Lys His Ser
    530                 535                 540
Gly Arg Gln Leu Thr Leu Gln His His Met Gly Ser Ala Asp Leu Asn
545                 550                 555                 560
Ala Thr Phe Tyr Gly Pro Val Lys Lys Glu Asp Gly Ser Glu Val Gly
                565                 570                 575
Val Gly Gly Ala Gln Val Thr Gly Ser Asn Thr Arg Lys His Ile Leu
            580                 585                 590
Gln Val Ser Thr Phe Gln Met Thr Ile Leu Met Leu Phe Asn Asn Arg
        595                 600                 605
Glu Lys Tyr Thr Phe Glu Glu Ile Gln Gln Glu Thr Asp Ile Pro Glu
    610                 615                 620
Arg Glu Leu Val Arg Ala Leu Gln Ser Leu Ala Cys Gly Lys Pro Thr
625                 630                 635                 640
Gln Arg Val Leu Thr Lys Glu Pro Lys Ser Lys Glu Ile Glu Asn Gly
                645                 650                 655
His Ile Phe Thr Val Asn Asp Gln Phe Thr Ser Lys Leu His Arg Val
            660                 665                 670
Lys Ile Gln Thr Val Ala Ala Lys Gln Gly Glu Ser Asp Pro Glu Arg
        675                 680                 685
Lys Glu Thr Arg Gln Lys Val Asp Asp Asp Arg Lys His Glu Ile Glu
    690                 695                 700
Ala Ala Ile Val Arg Ile Met Lys Ser Arg Lys Lys Met Gln His Asn
705                 710                 715                 720
Val Leu Val Ala Glu Val Thr Gln Gln Leu Lys Ala Arg Phe Leu Pro
                725                 730                 735
Ser Pro Val Val Ile Lys Lys Arg Ile Glu Gly Leu Ile Glu Arg Glu
            740                 745                 750
Tyr Leu Ala Arg Thr Pro Glu Asp Arg Lys Val Tyr Thr Tyr Val Ala
        755                 760                 765

<210> 17
<211> 327
<212> PRT
<213> Homo sapiens

<400> 17
Met Arg Ala Leu Pro Gly Leu Leu Glu Ala Arg Ala Arg Thr Pro Arg
 1               5                  10                  15
Leu Leu Leu Leu Gln Cys Leu Leu Ala Ala Ala Arg Pro Ser Ser Ala
            20                  25                  30
Asp Gly Ser Ala Pro Asp Ser Pro Phe Thr Ser Pro Pro Leu Arg Glu
        35                  40                  45
Glu Ile Met Ala Asn Asn Phe Ser Leu Glu Ser His Asn Ile Ser Leu
    50                  55                  60
Thr Glu His Ser Ser Met Pro Val Glu Lys Asn Ile Thr Leu Glu Arg
65                  70                  75                  80
Pro Ser Asn Val Asn Leu Thr Cys Gln Phe Thr Thr Ser Gly Asp Leu
                85                  90                  95
Asn Ala Val Asn Val Thr Trp Lys Lys Asp Gly Glu Gln Leu Glu Asn
            100                 105                 110
Asn Tyr Leu Val Ser Ala Thr Gly Ser Thr Leu Tyr Thr Gln Tyr Arg
        115                 120                 125
Phe Thr Ile Ile Asn Ser Lys Gln Met Gly Ser Tyr Ser Cys Phe Phe
    130                 135                 140
Arg Glu Glu Lys Glu Gln Arg Gly Thr Phe Asn Phe Lys Val Pro Glu
145                 150                 155                 160
Leu His Gly Lys Asn Lys Pro Leu Ile Ser Tyr Val Gly Asp Ser Thr
                165                 170                 175
Val Leu Thr Cys Lys Cys Gln Asn Cys Phe Pro Leu Asn Trp Thr Trp
            180                 185                 190
Tyr Ser Ser Asn Gly Ser Val Lys Val Pro Val Gly Val Gln Met Asn
        195                 200                 205
Lys Tyr Val Ile Asn Gly Thr Tyr Ala Asn Glu Thr Lys Leu Lys Ile
    210                 215                 220
Thr Gln Leu Leu Glu Glu Asp Gly Glu Ser Tyr Trp Cys Arg Ala Leu
225                 230                 235                 240
Phe Gln Leu Gly Glu Ser Glu Glu His Ile Glu Leu Val Val Leu Ser
                245                 250                 255
Tyr Leu Val Pro Leu Lys Pro Phe Leu Val Ile Val Ala Glu Val Ile
            260                 265                 270
Leu Leu Val Ala Thr Ile Leu Leu Cys Glu Lys Tyr Thr Gln Lys Lys
        275                 280                 285
Lys Lys His Ser Asp Glu Gly Lys Glu Phe Glu Gln Ile Glu Gln Leu
    290                 295                 300
Lys Ser Asp Asp Ser Asn Gly Ile Glu Asn Asn Val Pro Arg His Arg
305                 310                 315                 320
Lys Asn Glu Ser Leu Gly Gln
                325

<210> 18
<211> 681
<212> PRT
<213> Homo sapiens

<400> 18
Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala
 1               5                  10                  15
Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu
            20                  25                  30
Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu
        35                  40                  45
His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys
    50                  55                  60
Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln
65                  70                  75                  80
Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu
                85                  90                  95
Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu
            100                 105                 110
His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu
        115                 120                 125
Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys
    130                 135                 140
Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr
145                 150                 155                 160
Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr
                165                 170                 175
Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile
            180                 185                 190
Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr
        195                 200                 205
Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn
    210                 215                 220
Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp
225                 230                 235                 240
Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala
                245                 250                 255
Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg
            260                 265                 270
Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His
        275                 280                 285
His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp
    290                 295                 300
Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu
305                 310                 315                 320
Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr
                325                 330                 335
Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile
            340                 345                 350
Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg
        355                 360                 365
Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln
    370                 375                 380
Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu
385                 390                 395                 400
Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe
                405                 410                 415
Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val
            420                 425                 430
Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg
        435                 440                 445
Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe
    450                 455                 460
Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val
465                 470                 475                 480
Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys
                485                 490                 495
Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn
            500                 505                 510
Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met
        515                 520                 525
Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro
    530                 535                 540
Pro Pro Cys Lys Leu Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro
545                 550                 555                 560
Ala Pro Ala Ala Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser
                565                 570                 575
Val Ile Leu Asn Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro
            580                 585                 590
Ala Gly Thr Gln Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro
        595                 600                 605
Pro Gly Ser Pro Asn Ser Leu Gly Tyr Phe Pro Thr Ala Ala Asn Leu
    610                 615                 620
Ser Gly Val Pro Pro Gln Pro Gly Thr Val Val Arg Met Gln Gly Leu
625                 630                 635                 640
Ala Tyr Asn Thr Gly Val Lys Glu Ile Leu Asn Phe Phe Gln Gly Tyr
                645                 650                 655
Gln Tyr Ala Thr Glu Asp Gly Leu Ile His Thr Asn Asp Gln Ala Arg
            660                 665                 670
Thr Leu Pro Lys Glu Trp Val Cys Ile
        675                 680

<210> 19
<211> 735
<212> PRT
<213> Homo sapiens

<400> 19
Met Thr Pro Glu Leu Met Ile Lys Ala Cys Ser Phe Tyr Thr Gly His
 1               5                  10                  15
Leu Val Lys Thr His Phe Cys Thr Trp Arg Asp Ile Ala Arg Thr Asn
            20                  25                  30
Glu Asn Val Val Leu Ala Glu Lys Met Asn Arg Ala Val Thr Cys Tyr
        35                  40                  45
Asn Phe Arg Leu Gln Lys Ser Val Phe His His Trp His Ser Tyr Met
    50                  55                  60
Glu Asp Gln Lys Glu Lys Leu Lys Asn Ile Leu Leu Arg Ile Gln Gln
65                  70                  75                  80
Ile Ile Tyr Cys His Lys Leu Thr Ile Ile Leu Thr Lys Trp Arg Asn
                85                  90                  95
Thr Ala Arg His Lys Ser Lys Lys Lys Glu Asp Glu Leu Ile Leu Lys
            100                 105                 110
His Glu Leu Gln Leu Lys Lys Trp Lys Asn Arg Leu Ile Leu Lys Arg
        115                 120                 125
Ala Ala Ala Glu Glu Ser Asn Phe Pro Glu Arg Ser Ser Ser Glu Val
    130                 135                 140
Phe Leu Val Asp Glu Thr Leu Lys Cys Asp Ile Ser Leu Leu Pro Glu
145                 150                 155                 160
Arg Ala Ile Leu Gln Ile Phe Phe Tyr Leu Ser Leu Lys Asp Val Ile
                165                 170                 175
Ile Cys Gly Gln Val Asn His Ala Trp Met Leu Met Thr Gln Leu Asn
            180                 185                 190
Ser Leu Trp Asn Ala Ile Asp Phe Ser Ser Val Lys Asn Val Ile Pro
        195                 200                 205
Asp Lys Tyr Ile Val Ser Thr Leu Gln Arg Trp Arg Leu Asn Val Leu
    210                 215                 220
Arg Leu Asn Phe Arg Gly Cys Leu Leu Arg Pro Lys Thr Phe Arg Ser
225                 230                 235                 240
Val Ser His Cys Arg Asn Leu Gln Glu Leu Asn Val Ser Asp Cys Pro
                245                 250                 255
Thr Phe Thr Asp Glu Ser Met Arg His Ile Ser Glu Gly Cys Pro Gly
            260                 265                 270
Val Leu Cys Leu Asn Leu Ser Asn Thr Thr Ile Thr Asn Arg Thr Met
        275                 280                 285
Arg Leu Leu Pro Arg His Phe His Asn Leu Gln Asn Leu Ser Leu Ala
    290                 295                 300
Tyr Cys Arg Arg Phe Thr Asp Lys Gly Leu Gln Tyr Leu Asn Leu Gly
305                 310                 315                 320
Asn Gly Cys His Lys Leu Ile Tyr Leu Asp Leu Ser Gly Cys Thr Gln
                325                 330                 335
Ile Ser Val Gln Gly Phe Arg Tyr Ile Ala Asn Ser Cys Thr Gly Ile
            340                 345                 350
Met His Leu Thr Ile Asn Asp Met Pro Thr Leu Thr Asp Asn Cys Val
        355                 360                 365
Lys Ala Leu Val Glu Lys Cys Ser Arg Ile Thr Ser Leu Val Phe Thr
    370                 375                 380
Gly Ala Pro His Ile Ser Asp Cys Thr Phe Arg Ala Leu Ser Ala Cys
385                 390                 395                 400
Lys Leu Arg Lys Ile Arg Phe Glu Gly Asn Lys Arg Val Thr Asp Ala
                405                 410                 415
Ser Phe Lys Phe Ile Asp Lys Asn Tyr Pro Asn Leu Ser His Ile Tyr
            420                 425                 430
Met Ala Asp Cys Lys Gly Ile Thr Asp Ser Ser Leu Arg Ser Leu Ser
        435                 440                 445
Pro Leu Lys Gln Leu Thr Val Leu Asn Leu Ala Asn Cys Val Arg Ile
    450                 455                 460
Gly Asp Met Gly Leu Lys Gln Phe Leu Asp Gly Pro Ala Ser Met Arg
465                 470                 475                 480
Ile Arg Glu Leu Asn Leu Ser Asn Cys Val Arg Leu Ser Asp Ala Ser
                485                 490                 495
Val Met Lys Leu Ser Glu Arg Cys Pro Asn Leu Asn Tyr Leu Ser Leu
            500                 505                 510
Arg Asn Cys Glu His Leu Thr Ala Gln Gly Ile Gly Tyr Ile Val Asn
        515                 520                 525
Ile Phe Ser Leu Val Ser Ile Asp Leu Ser Gly Thr Asp Ile Ser Asn
    530                 535                 540
Glu Gly Leu Asn Val Leu Ser Arg His Lys Lys Leu Lys Glu Leu Ser
545                 550                 555                 560
Val Ser Glu Cys Tyr Arg Ile Thr Asp Asp Gly Ile Gln Ala Phe Cys
                565                 570                 575
Lys Ser Ser Leu Ile Leu Glu His Leu Asp Val Ser Tyr Cys Ser Gln
            580                 585                 590
Leu Ser Asp Met Ile Ile Lys Ala Leu Ala Ile Tyr Cys Ile Asn Leu
        595                 600                 605
Thr Ser Leu Ser Ile Ala Gly Cys Pro Lys Ile Thr Asp Ser Ala Met
    610                 615                 620
Glu Met Leu Ser Ala Lys Cys His Tyr Leu His Ile Leu Asp Ile Ser
625                 630                 635                 640
Gly Cys Val Leu Leu Thr Asp Gln Ile Leu Glu Asp Leu Gln Ile Gly
                645                 650                 655
Cys Lys Gln Leu Arg Ile Leu Lys Met Gln Tyr Cys Thr Asn Ile Ser
            660                 665                 670
Lys Lys Ala Ala Gln Arg Met Ser Ser Lys Val Gln Gln Gln Glu Tyr
        675                 680                 685
Asn Thr Asn Asp Pro Pro Arg Trp Phe Gly Tyr Asp Arg Glu Gly Asn
    690                 695                 700
Pro Val Thr Glu Leu Asp Asn Ile Thr Ser Ser Lys Gly Ala Leu Glu
705                 710                 715                 720
Leu Thr Val Lys Lys Ser Thr Tyr Ser Ser Glu Asp Gln Ala Ala
                725                 730                 735

<210> 20
<211> 875
<212> PRT
<213> Homo sapiens

<400> 20
Met Ala Ser Leu Asp Leu Pro Tyr Arg Cys Pro Arg Cys Gly Glu His
 1               5                  10                  15
Lys Arg Phe Arg Ser Leu Ser Ser Leu Arg Ala His Leu Glu Tyr Ser
            20                  25                  30
His Thr Tyr Glu Thr Leu Tyr Ile Leu Ser Lys Thr Asn Ser Ile Cys
        35                  40                  45
Asp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Phe
    50                  55                  60
Pro Leu Ala Pro Glu Pro Ala Ala Leu Leu Ala Val Pro Gly Ala Arg
65                  70                  75                  80
Arg Glu Val Phe Glu Ser Thr Ser Phe Gln Gly Lys Glu Gln Ala Ala
                85                  90                  95
Gly Pro Ser Pro Ala Ala Pro His Leu Leu His His His His His His
            100                 105                 110
Ala Pro Leu Ala His Phe Pro Gly Asp Leu Val Pro Ala Ser Leu Pro
        115                 120                 125
Cys Glu Glu Leu Ala Glu Pro Gly Leu Val Pro Ala Ala Ala Ala Arg
    130                 135                 140
Tyr Ala Leu Arg Glu Ile Glu Ile Pro Leu Gly Glu Leu Phe Ala Arg
145                 150                 155                 160
Lys Ser Val Ala Ser Ser Ala Cys Ser Thr Pro Pro Pro Gly Pro Gly
                165                 170                 175
Pro Gly Pro Cys Pro Gly Pro Ala Ser Ala Ser Pro Ala Ser Pro Ser
            180                 185                 190
Pro Ala Asp Val Ala Tyr Glu Glu Gly Leu Ala Arg Leu Lys Ile Arg
        195                 200                 205
Ala Leu Glu Lys Leu Glu Val Asp Arg Arg Leu Glu Arg Leu Ser Glu
    210                 215                 220
Glu Val Glu Gln Lys Ile Ala Gly Gln Val Gly Arg Leu Gln Ala Glu
225                 230                 235                 240
Leu Glu Arg Lys Ala Ala Glu Leu Glu Thr Ala Arg Gln Glu Ser Ala
                245                 250                 255
Arg Leu Gly Arg Glu Lys Glu Glu Leu Glu Glu Arg Ala Ser Glu Leu
            260                 265                 270
Ser Arg Gln Val Asp Val Ser Val Glu Leu Leu Ala Ser Leu Lys Gln
        275                 280                 285
Asp Leu Val His Lys Glu Gln Glu Leu Ser Arg Lys Gln Gln Glu Val
    290                 295                 300
Val Gln Ile Asp Gln Phe Leu Lys Glu Thr Ala Ala Arg Glu Ala Ser
305                 310                 315                 320
Ala Lys Leu Arg Leu Gln Gln Phe Ile Glu Glu Leu Leu Glu Arg Ala
                325                 330                 335
Asp Arg Ala Glu Arg Gln Leu Gln Val Ile Ser Ser Ser Cys Gly Ser
            340                 345                 350
Thr Pro Ser Ala Ser Leu Gly Arg Gly Gly Gly Gly Gly Gly Ala Gly
        355                 360                 365
Pro Asn Ala Arg Gly Pro Gly Arg Met Arg Glu His His Val Gly Pro
    370                 375                 380
Ala Val Pro Asn Thr Tyr Ala Val Ser Arg His Gly Ser Ser Pro Ser
385                 390                 395                 400
Thr Gly Ala Ser Ser Arg Val Pro Ala Ala Ser Gln Ser Ser Gly Cys
                405                 410                 415
Tyr Asp Ser Asp Ser Leu Glu Leu Pro Arg Pro Glu Glu Gly Ala Pro
            420                 425                 430
Glu Asp Ser Gly Pro Gly Gly Leu Gly Thr Arg Ala Gln Ala Ala Asn
        435                 440                 445
Gly Gly Ser Glu Arg Ser Gln Pro Pro Arg Ser Ser Gly Leu Arg Arg
    450                 455                 460
Gln Ala Ile Gln Asn Trp Gln Arg Arg Pro Arg Arg His Ser Thr Glu
465                 470                 475                 480
Gly Glu Glu Gly Asp Val Ser Asp Val Gly Ser Arg Thr Thr Glu Ser
                485                 490                 495
Glu Ala Glu Gly Pro Leu Asp Ala Pro Arg Pro Gly Pro Ala Met Ala
            500                 505                 510
Gly Pro Leu Ser Ser Cys Arg Leu Ser Ala Arg Pro Glu Gly Gly Ser
        515                 520                 525
Gly Arg Gly Arg Arg Ala Glu Arg Val Ser Pro Ser Arg Ser Asn Glu
    530                 535                 540
Val Ile Ser Pro Glu Ile Leu Lys Met Arg Ala Ala Leu Phe Cys Ile
545                 550                 555                 560
Phe Thr Tyr Leu Asp Thr Arg Thr Leu Leu His Ala Ala Glu Val Cys
                565                 570                 575
Arg Asp Trp Arg Phe Val Ala Arg His Pro Ala Val Trp Thr Arg Val
            580                 585                 590
Leu Leu Glu Asn Ala Arg Val Cys Ser Lys Phe Leu Ala Met Leu Ala
        595                 600                 605
Gln Trp Cys Thr Gln Ala His Ser Leu Thr Leu Gln Asn Leu Lys Pro
    610                 615                 620
Arg Gln Arg Gly Lys Lys Glu Ser Lys Glu Glu Tyr Ala Arg Ser Thr
625                 630                 635                 640
Arg Gly Cys Leu Glu Ala Gly Leu Glu Ser Leu Leu Lys Ala Ala Gly
                645                 650                 655
Gly Asn Leu Leu Ile Leu Arg Ile Ser His Cys Pro Asn Ile Leu Thr
            660                 665                 670
Asp Arg Ser Leu Trp Leu Ala Ser Cys Tyr Cys Arg Ala Leu Gln Ala
        675                 680                 685
Val Thr Tyr Arg Ser Ala Thr Asp Pro Val Gly His Glu Val Ile Trp
    690                 695                 700
Ala Leu Gly Ala Gly Cys Arg Glu Ile Val Ser Leu Gln Val Ala Pro
705                 710                 715                 720
Leu His Pro Cys Gln Gln Pro Thr Arg Phe Ser Asn Arg Cys Leu Gln
                725                 730                 735
Met Ile Gly Arg Cys Trp Pro His Leu Arg Ala Leu Gly Val Gly Gly
            740                 745                 750
Ala Gly Cys Gly Val Gln Gly Leu Ala Ser Leu Ala Arg Asn Cys Met
        755                 760                 765
Arg Leu Gln Val Leu Glu Leu Asp His Val Ser Glu Ile Thr Gln Glu
    770                 775                 780
Val Ala Ala Glu Val Cys Arg Glu Gly Leu Lys Gly Leu Glu Met Leu
785                 790                 795                 800
Val Leu Thr Ala Thr Pro Val Thr Pro Lys Ala Leu Leu His Phe Asn
                805                 810                 815
Ser Ile Cys Arg Asn Leu Lys Ser Ile Val Val Gln Ile Gly Ile Ala
            820                 825                 830
Asp Tyr Phe Lys Glu Pro Ser Ser Pro Glu Ala Gln Lys Leu Phe Glu
        835                 840                 845
Asp Met Val Thr Lys Leu Gln Ala Leu Arg Arg Arg Pro Gly Phe Ser
    850                 855                 860
Lys Ile Leu His Ile Lys Val Glu Gly Gly Cys
865                 870                 875

<210> 21
<211> 271
<212> PRT
<213> Homo sapiens

<400> 21
Met Phe Arg Asp Phe Gly Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly
 1               5                  10                  15
Gly Tyr Gly Gly Pro Ala Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln
            20                  25                  30
Gln Lys Phe His Leu Val Pro Ser Ile Asn Thr Met Ser Gly Ser Gln
        35                  40                  45
Glu Leu Gln Trp Met Val Gln Pro His Phe Leu Gly Pro Ser Ser Tyr
    50                  55                  60
Pro Arg Pro Leu Thr Tyr Pro Gln Tyr Ser Pro Pro Gln Pro Arg Pro
65                  70                  75                  80
Gly Val Ile Arg Ala Leu Gly Pro Pro Pro Gly Val Arg Arg Arg Pro
                85                  90                  95
Cys Glu Gln Ile Ser Pro Glu Glu Glu Glu Arg Arg Arg Val Arg Arg
            100                 105                 110
Glu Arg Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg Arg Lys Glu
        115                 120                 125
Leu Thr Asp Phe Leu Gln Ala Glu Thr Asp Lys Leu Glu Asp Glu Lys
    130                 135                 140
Ser Gly Leu Gln Arg Glu Ile Glu Glu Leu Gln Lys Gln Lys Glu Arg
145                 150                 155                 160
Leu Glu Leu Val Leu Glu Ala His Arg Pro Ile Cys Lys Ile Pro Glu
                165                 170                 175
Gly Ala Lys Glu Gly Asp Thr Gly Ser Thr Ser Gly Thr Ser Ser Pro
            180                 185                 190
Pro Ala Pro Cys Arg Pro Val Pro Cys Ile Ser Leu Ser Pro Gly Pro
        195                 200                 205
Val Leu Glu Pro Glu Ala Leu His Thr Pro Thr Leu Met Thr Thr Pro
    210                 215                 220
Ser Leu Thr Pro Phe Thr Pro Ser Leu Val Phe Thr Tyr Pro Ser Thr
225                 230                 235                 240
Pro Glu Pro Cys Ala Ser Ala His Arg Lys Ser Ser Ser Ser Ser Gly
                245                 250                 255
Asp Pro Ser Ser Asp Pro Leu Gly Ser Pro Thr Leu Leu Ala Leu
            260                 265                 270

<210> 22
<211> 505
<212> PRT
<213> Homo sapiens

<400> 22
Met Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile
 1               5                  10                  15
Asp Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr
            20                  25                  30
Trp Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro
        35                  40                  45
Glu Val Glu Pro Asp Leu Gly Glu Lys Val His Thr Glu Gly Arg Ser
    50                  55                  60
Glu Pro Ile Leu Leu Pro Ser Arg Leu Pro Glu Pro Ala Gly Gly Pro
65                  70                  75                  80
Gln Pro Gly Ile Leu Gly Ala Val Thr Gly Pro Arg Lys Gly Gly Ser
                85                  90                  95
Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser Gln
            100                 105                 110
Ala Ile Glu Ser Ala Pro Glu Lys Arg Leu Thr Leu Ala Gln Ile Tyr
        115                 120                 125
Glu Trp Met Val Arg Thr Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser
    130                 135                 140
Asn Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu
145                 150                 155                 160
His Ser Lys Phe Ile Lys Val His Asn Glu Ala Thr Gly Lys Ser Ser
                165                 170                 175
Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ala Pro Arg
            180                 185                 190
Arg Arg Ala Ala Ser Met Asp Ser Ser Ser Lys Leu Leu Arg Gly Arg
        195                 200                 205
Ser Lys Ala Pro Lys Lys Lys Pro Ser Val Leu Pro Ala Pro Pro Glu
    210                 215                 220
Gly Ala Thr Pro Thr Ser Pro Val Gly His Phe Ala Lys Trp Ser Gly
225                 230                 235                 240
Ser Pro Cys Ser Arg Asn Arg Glu Glu Ala Asp Met Trp Thr Thr Phe
                245                 250                 255
Arg Pro Arg Ser Ser Ser Asn Ala Ser Ser Val Ser Thr Arg Leu Ser
            260                 265                 270
Pro Leu Arg Pro Glu Ser Glu Val Leu Ala Glu Glu Ile Pro Ala Ser
        275                 280                 285
Val Ser Ser Tyr Ala Gly Gly Val Pro Pro Thr Leu Asn Glu Gly Leu
    290                 295                 300
Glu Leu Leu Asp Gly Leu Asn Leu Thr Ser Ser His Ser Leu Leu Ser
305                 310                 315                 320
Arg Ser Gly Leu Ser Gly Phe Ser Leu Gln His Pro Gly Val Thr Gly
                325                 330                 335
Pro Leu His Thr Tyr Ser Ser Ser Leu Phe Ser Pro Ala Glu Gly Pro
            340                 345                 350
Leu Ser Ala Gly Glu Gly Cys Phe Ser Ser Ser Gln Ala Leu Glu Ala
        355                 360                 365
Leu Leu Thr Ser Asp Thr Pro Pro Pro Pro Ala Asp Val Leu Met Thr
    370                 375                 380
Gln Val Asp Pro Ile Leu Ser Gln Ala Pro Thr Leu Leu Leu Leu Gly
385                 390                 395                 400
Gly Leu Pro Ser Ser Ser Lys Leu Ala Thr Gly Val Gly Leu Cys Pro
                405                 410                 415
Lys Pro Leu Glu Ala Pro Gly Pro Ser Ser Leu Val Pro Thr Leu Ser
            420                 425                 430
Met Ile Ala Pro Pro Pro Val Met Ala Ser Ala Pro Ile Pro Lys Ala
        435                 440                 445
Leu Gly Thr Pro Val Leu Thr Pro Pro Thr Glu Ala Ala Ser Gln Asp
    450                 455                 460
Arg Met Pro Gln Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu
465                 470                 475                 480
Cys Asp Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly
                485                 490                 495
Leu Asp Phe Asn Phe Glu Pro Asp Pro
            500                 505

<210> 23
<211> 418
<212> PRT
<213> Homo sapiens

<400> 23
Met Gly Glu Glu Gly Thr Gly Gly Thr Val His Leu Leu Cys Leu Ala
 1               5                  10                  15
Ala Ser Ser Gly Val Pro Leu Phe Cys Arg Ser Ser Arg Gly Gly Ala
            20                  25                  30
Pro Ala Arg Gln Gln Leu Pro Phe Ser Val Ile Gly Ser Leu Asn Gly
        35                  40                  45
Val His Met Phe Gly Gln Asn Leu Glu Val Gln Leu Ser Ser Ala Arg
    50                  55                  60
Thr Glu Asn Thr Thr Val Val Trp Lys Ser Phe His Asp Ser Ile Thr
65                  70                  75                  80
Leu Ile Val Leu Ser Ser Glu Val Gly Ile Ser Glu Leu Arg Leu Glu
                85                  90                  95
Arg Leu Leu Gln Met Val Phe Gly Ala Met Val Leu Leu Val Gly Leu
            100                 105                 110
Glu Glu Leu Thr Asn Ile Arg Asn Val Glu Arg Leu Lys Lys Asp Leu
        115                 120                 125
Arg Ala Ser Tyr Cys Leu Ile Asp Ser Phe Leu Gly Asp Ser Glu Leu
    130                 135                 140
Ile Gly Asp Leu Thr Gln Cys Val Asp Cys Val Ile Pro Pro Glu Gly
145                 150                 155                 160
Ser Leu Leu Gln Glu Ala Leu Ser Gly Phe Ala Glu Ala Ala Gly Thr
                165                 170                 175
Thr Phe Val Ser Leu Val Val Ser Gly Arg Val Val Ala Ala Thr Glu
            180                 185                 190
Gly Trp Trp Arg Leu Gly Thr Pro Glu Ala Val Leu Leu Pro Trp Leu
        195                 200                 205
Val Gly Ser Leu Pro Pro Gln Thr Ala Arg Asp Tyr Pro Val Tyr Leu
    210                 215                 220
Pro His Gly Ser Pro Thr Val Pro His Arg Leu Leu Thr Leu Thr Leu
225                 230                 235                 240
Leu Pro Ser Leu Glu Leu Cys Leu Leu Cys Gly Pro Ser Pro Pro Leu
                245                 250                 255
Ser Gln Leu Tyr Pro Gln Leu Leu Glu Arg Trp Trp Gln Pro Leu Leu
            260                 265                 270
Asp Pro Leu Arg Ala Cys Leu Pro Leu Gly Pro Arg Ala Leu Pro Ser
        275                 280                 285
Gly Phe Pro Leu His Thr Asp Ile Leu Gly Leu Leu Leu Leu His Leu
    290                 295                 300
Glu Leu Lys Arg Cys Leu Phe Thr Val Glu Pro Leu Gly Asp Lys Glu
305                 310                 315                 320
Pro Ser Pro Glu Gln Arg Arg Arg Leu Leu Arg Asn Phe Tyr Thr Leu
                325                 330                 335
Val Thr Ser Thr His Phe Pro Pro Glu Pro Gly Pro Pro Glu Lys Thr
            340                 345                 350
Glu Asp Glu Val Tyr Gln Ala Gln Leu Pro Arg Ala Cys Tyr Leu Val
        355                 360                 365
Leu Gly Thr Glu Glu Pro Gly Thr Gly Val Arg Leu Val Ala Leu Gln
    370                 375                 380
Leu Gly Leu Arg Arg Leu Leu Leu Leu Leu Ser Pro Gln Ser Pro Thr
385                 390                 395                 400
His Gly Leu Arg Ser Leu Ala Thr His Thr Leu His Ala Leu Thr Pro
                405                 410                 415
Leu Leu


<210> 24
<211> 464
<212> PRT
<213> Homo sapiens

<400> 24
Met Val Arg Leu Ala Ala Glu Leu Leu Leu Leu Leu Gly Leu Leu Leu
 1               5                  10                  15
Leu Thr Leu His Ile Thr Val Leu Arg Gly Ser Gly Ala Ala Asp Gly
            20                  25                  30
Pro Asp Ala Ala Ala Gly Asn Ala Ser Gln Ala Gln Leu Gln Asn Asn
        35                  40                  45
Leu Asn Val Gly Ser Asp Thr Thr Ser Glu Thr Ser Phe Ser Leu Ser
    50                  55                  60
Lys Glu Ala Pro Arg Glu His Leu Asp His Gln Ala Ala His Gln Pro
65                  70                  75                  80
Phe Pro Arg Pro Arg Phe Arg Gln Glu Thr Gly His Pro Ser Leu Gln
                85                  90                  95
Arg Asp Phe Pro Arg Ser Phe Leu Leu Asp Leu Pro Asn Phe Pro Asp
            100                 105                 110
Leu Ser Lys Ala Asp Ile Asn Gly Gln Asn Pro Asn Ile Gln Val Thr
        115                 120                 125
Ile Glu Val Val Asp Gly Pro Asp Ser Glu Ala Asp Lys Asp Gln His
    130                 135                 140
Pro Glu Asn Lys Pro Ser Trp Ser Val Pro Ser Pro Asp Trp Arg Ala
145                 150                 155                 160
Trp Trp Gln Arg Ser Leu Ser Leu Ala Arg Ala Asn Ser Gly Asp Gln
                165                 170                 175
Asp Tyr Lys Tyr Asp Ser Thr Ser Asp Asp Ser Asn Phe Leu Asn Pro
            180                 185                 190
Pro Arg Gly Trp Asp His Thr Ala Pro Gly His Arg Thr Phe Glu Thr
        195                 200                 205
Lys Asp Gln Pro Glu Tyr Asp Ser Thr Asp Gly Glu Gly Asp Trp Ser
    210                 215                 220
Leu Trp Ser Val Cys Ser Val Thr Cys Gly Asn Gly Asn Gln Lys Arg
225                 230                 235                 240
Thr Arg Ser Cys Gly Tyr Ala Cys Thr Ala Thr Glu Ser Arg Thr Cys
                245                 250                 255
Asp Arg Pro Asn Cys Pro Gly Ile Glu Asp Thr Phe Arg Thr Ala Ala
            260                 265                 270
Thr Glu Val Ser Leu Leu Ala Gly Ser Glu Glu Phe Asn Ala Thr Lys
        275                 280                 285
Leu Phe Glu Val Asp Thr Asp Ser Cys Glu Arg Trp Met Ser Cys Lys
    290                 295                 300
Ser Glu Phe Leu Lys Lys Tyr Met His Lys Val Met Asn Asp Leu Pro
305                 310                 315                 320
Ser Cys Pro Cys Ser Tyr Pro Thr Glu Val Ala Tyr Ser Thr Ala Asp
                325                 330                 335
Ile Phe Asp Arg Ile Lys Arg Lys Asp Phe Arg Trp Lys Asp Ala Ser
            340                 345                 350
Gly Pro Lys Glu Lys Leu Glu Ile Tyr Lys Pro Thr Ala Arg Tyr Cys
        355                 360                 365
Ile Arg Ser Met Leu Ser Leu Glu Ser Thr Thr Leu Ala Ala Gln His
    370                 375                 380
Cys Cys Tyr Gly Asp Asn Met Gln Leu Ile Thr Arg Gly Lys Gly Ala
385                 390                 395                 400
Gly Thr Pro Asn Leu Ile Ser Thr Glu Phe Ser Ala Glu Leu His Tyr
                405                 410                 415
Lys Val Asp Val Leu Pro Trp Ile Ile Cys Lys Gly Asp Trp Ser Arg
            420                 425                 430
Tyr Asn Glu Ala Arg Pro Pro Asn Asn Gly Gln Lys Cys Thr Glu Ser
        435                 440                 445
Pro Ser Asp Glu Asp Tyr Ile Lys Gln Phe Gln Glu Ala Arg Glu Tyr
    450                 455                 460

<210> 25
<211> 709
<212> PRT
<213> Homo sapiens

<400> 25
Met Trp Trp Gly Gly Arg Gly Gln Ser Phe Asn Ile Ala Pro Gln Lys
 1               5                  10                  15
Glu Glu Pro Glu Met Gly Ser Val Gln Glu Asn Arg Met Pro Glu Pro
            20                  25                  30
Arg Ser Arg Gln Pro Ser Ser Cys Leu Ala Ser Arg Cys Leu Pro Gly
        35                  40                  45
Glu Gln Ile Leu Ala Trp Ala Pro Gly Val Arg Lys Gly Leu Glu Pro
    50                  55                  60
Glu Leu Ser Gly Thr Leu Ile Cys Thr Asn Phe Arg Val Thr Phe Gln
65                  70                  75                  80
Pro Cys Gly Trp Gln Trp Asn Gln Asp Thr Pro Leu Asn Ser Glu Tyr
                85                  90                  95
Asp Phe Ala Leu Val Asn Ile Gly Arg Leu Glu Ala Val Ser Gly Leu
            100                 105                 110
Ser Arg Val Gln Leu Leu Arg Pro Gly Ser Leu His Lys Phe Ile Pro
        115                 120                 125
Glu Glu Ile Leu Ile His Gly Arg Asp Phe Arg Leu Leu Arg Val Gly
    130                 135                 140
Phe Glu Ala Gly Gly Leu Glu Pro Gln Ala Phe Gln Val Thr Met Ala
145                 150                 155                 160
Ile Val Gln Ala Arg Ala Gln Ser Asn Gln Ala Gln Gln Tyr Ser Gly
                165                 170                 175
Ile Thr Leu Ser Lys Ala Gly Gln Gly Ser Gly Ser Arg Lys Pro Pro
            180                 185                 190
Ile Pro Leu Met Glu Thr Ala Glu Asp Trp Glu Thr Glu Arg Lys Lys
        195                 200                 205
Gln Ala Ala Arg Gly Trp Arg Val Ser Thr Val Asn Glu Arg Phe Asp
    210                 215                 220
Val Ala Thr Ser Leu Pro Arg Tyr Phe Trp Val Pro Asn Arg Ile Leu
225                 230                 235                 240
Asp Ser Glu Val Arg Arg Ala Phe Gly His Phe His Gln Gly Arg Gly
                245                 250                 255
Pro Arg Leu Ser Trp His His Pro Gly Gly Ser Asp Leu Leu Arg Cys
            260                 265                 270
Gly Gly Phe Tyr Thr Ala Ser Asp Pro Asn Lys Glu Asp Ile Arg Ala
        275                 280                 285
Val Glu Leu Met Leu Gln Ala Gly His Ser Asp Val Val Leu Val Asp
    290                 295                 300
Thr Met Asp Glu Leu Pro Ser Leu Ala Asp Val Gln Leu Ala His Leu
305                 310                 315                 320
Arg Leu Arg Ala Leu Cys Leu Pro Asp Ser Ser Val Ala Glu Asp Lys
                325                 330                 335
Trp Leu Ser Ala Leu Glu Gly Thr Arg Trp Leu Asp Tyr Val Arg Ala
            340                 345                 350
Cys Leu Arg Lys Ala Ser Asp Ile Ser Val Leu Val Thr Ser Arg Val
        355                 360                 365
Arg Ser Val Ile Leu Gln Glu Arg Gly Asp Arg Asp Leu Asn Gly Leu
    370                 375                 380
Leu Ser Ser Leu Val Gln Leu Leu Ser Ala Pro Glu Ala Arg Thr Leu
385                 390                 395                 400
Phe Gly Phe Gln Ser Leu Val Gln Arg Glu Trp Val Ala Ala Gly His
                405                 410                 415
Pro Phe Leu Thr Arg Leu Gly Gly Thr Gly Ala Ser Glu Glu Ala Pro
            420                 425                 430
Val Phe Leu Leu Phe Leu Asp Cys Val Trp Gln Leu Leu Gln Gln Phe
        435                 440                 445
Pro Ala Asp Phe Glu Phe Ser Glu Phe Phe Leu Leu Ala Leu His Asp
    450                 455                 460
Ser Val Arg Val Pro Asp Thr Leu Thr Phe Leu Arg Asn Thr Pro Trp
465                 470                 475                 480
Glu Arg Gly Lys Gln Ser Gly Gln Leu Asn Ser Tyr Thr Gln Val Tyr
                485                 490                 495
Thr Pro Gly Tyr Ser Gln Pro Pro Ala Gly Asn Ser Phe Asn Leu Gln
            500                 505                 510
Leu Ser Val Trp Asp Trp Asp Leu Arg Tyr Ser Asn Ala Gln Ile Leu
        515                 520                 525
Gln Phe Gln Asn Pro Gly Tyr Asp Pro Glu His Cys Pro Asp Ser Trp
    530                 535                 540
Leu Pro Arg Pro Gln Pro Ser Phe Met Val Pro Gly Pro Pro Ser Ser
545                 550                 555                 560
Val Trp Leu Phe Ser Arg Gly Ala Leu Thr Pro Leu Asn Gln Leu Cys
                565                 570                 575
Pro Trp Arg Asp Ser Pro Ser Leu Leu Ala Val Ser Ser Arg Trp Leu
            580                 585                 590
Pro Arg Pro Ala Ile Ser Ser Glu Ser Leu Ala Asp Gln Glu Trp Gly
        595                 600                 605
Leu Pro Ser His Trp Gly Ala Cys Pro Leu Pro Pro Gly Leu Leu Leu
    610                 615                 620
Pro Gly Tyr Leu Gly Pro Gln Ile Arg Leu Trp Arg Arg Cys Tyr Leu
625                 630                 635                 640
Arg Gly Arg Pro Glu Val Gln Met Gly Leu Ser Ala Pro Thr Ile Ser
                645                 650                 655
Gly Leu Gln Asp Glu Leu Ser His Leu Gln Glu Leu Leu Arg Lys Trp
            660                 665                 670
Thr Pro Arg Ile Ser Pro Glu Asp His Ser Lys Lys Arg Asp Pro His
        675                 680                 685
Thr Ile Leu Asn Pro Thr Glu Ile Ala Gly Ile Leu Lys Gly Arg Ala
    690                 695                 700
Glu Gly Asp Leu Gly
705

<210> 26
<211> 375
<212> PRT
<213> Homo sapiens

<400> 26
Met Asp Glu Leu Gln Asp Val Gln Leu Thr Glu Ile Lys Pro Leu Leu
 1               5                  10                  15
Asn Asp Lys Asn Gly Thr Arg Asn Phe Gln Asp Phe Asp Cys Gln Glu
            20                  25                  30
His Asp Ile Glu Thr Thr His Gly Val Val His Val Thr Ile Arg Gly
        35                  40                  45
Leu Pro Lys Gly Asn Arg Pro Val Ile Leu Thr Tyr His Asp Ile Gly
    50                  55                  60
Leu Asn His Lys Ser Cys Phe Asn Ala Phe Phe Asn Phe Glu Asp Met
65                  70                  75                  80
Gln Glu Ile Thr Gln His Phe Ala Val Cys His Val Asp Ala Pro Gly
                85                  90                  95
Gln Gln Glu Gly Ala Pro Ser Phe Pro Thr Gly Tyr Gln Tyr Pro Thr
            100                 105                 110
Met Asp Glu Leu Ala Glu Met Leu Pro Pro Val Leu Thr His Leu Ser
        115                 120                 125
Leu Lys Ser Ile Ile Gly Ile Gly Val Gly Ala Gly Ala Tyr Ile Leu
    130                 135                 140
Ser Arg Phe Ala Leu Asn His Pro Glu Leu Val Glu Gly Leu Val Leu
145                 150                 155                 160
Ile Asn Val Asp Pro Cys Ala Lys Gly Trp Ile Asp Trp Ala Ala Ser
                165                 170                 175
Lys Leu Ser Gly Leu Thr Thr Asn Val Val Asp Ile Ile Leu Ala His
            180                 185                 190
His Phe Gly Gln Glu Glu Leu Gln Ala Asn Leu Asp Leu Ile Gln Thr
        195                 200                 205
Tyr Arg Met His Ile Ala Gln Asp Ile Asn Gln Asp Asn Leu Gln Leu
    210                 215                 220
Phe Leu Asn Ser Tyr Asn Gly Arg Arg Asp Leu Glu Ile Glu Arg Pro
225                 230                 235                 240
Ile Leu Gly Gln Asn Asp Asn Lys Ser Lys Thr Leu Lys Cys Ser Thr
                245                 250                 255
Leu Leu Val Val Gly Asp Asn Ser Pro Ala Val Glu Ala Val Val Glu
            260                 265                 270
Cys Asn Ser Arg Leu Asn Pro Ile Asn Thr Thr Leu Leu Lys Met Ala
        275                 280                 285
Asp Cys Gly Gly Leu Pro Gln Val Val Gln Pro Gly Lys Leu Thr Glu
    290                 295                 300
Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr Ile Pro Ser Ala Ser
305                 310                 315                 320
Met Thr Arg Leu Ala Arg Ser Arg Thr His Ser Thr Ser Ser Ser Leu
                325                 330                 335
Gly Ser Gly Glu Ser Pro Phe Ser Arg Ser Val Thr Ser Asn Gln Ser
            340                 345                 350
Asp Gly Thr Gln Glu Ser Cys Glu Ser Pro Asp Val Leu Asp Arg His
        355                 360                 365
Gln Thr Met Glu Val Ser Cys
    370                 375

<210> 27
<211> 608
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Glu Ser Ile Ile Ile Arg Val Gln Ser Pro Asp Gly Val Lys
 1               5                  10                  15
Arg Ile Thr Ala Thr Lys Arg Glu Thr Ala Ala Thr Phe Leu Lys Lys
            20                  25                  30
Val Ala Lys Glu Phe Gly Phe Gln Asn Asn Gly Phe Ser Val Tyr Ile
        35                  40                  45
Asn Arg Asn Lys Thr Gly Glu Ile Thr Ala Ser Ser Asn Lys Ser Leu
    50                  55                  60
Asn Leu Leu Lys Ile Lys His Gly Asp Leu Leu Phe Leu Phe Pro Ser
65                  70                  75                  80
Ser Leu Ala Gly Pro Ser Ser Glu Met Glu Thr Ser Val Pro Pro Gly
                85                  90                  95
Phe Lys Val Phe Gly Ala Pro Asn Val Val Glu Asp Glu Ile Asp Gln
            100                 105                 110
Tyr Leu Ser Lys Gln Asp Gly Lys Ile Tyr Arg Ser Arg Asp Pro Gln
        115                 120                 125
Leu Cys Arg His Gly Pro Leu Gly Lys Cys Val His Cys Val Pro Leu
    130                 135                 140
Glu Pro Phe Asp Glu Asp Tyr Leu Asn His Leu Glu Pro Pro Val Lys
145                 150                 155                 160
His Met Ser Phe His Ala Tyr Ile Arg Lys Leu Thr Gly Gly Ala Asp
                165                 170                 175
Lys Gly Lys Phe Val Ala Leu Glu Asn Ile Ser Cys Lys Ile Lys Ser
            180                 185                 190
Gly Cys Glu Gly His Leu Pro Trp Pro Asn Gly Ile Cys Thr Lys Cys
        195                 200                 205
Gln Pro Ser Ala Ile Thr Leu Asn Arg Gln Lys Tyr Arg His Val Asp
    210                 215                 220
Asn Ile Met Phe Glu Asn His Thr Val Ala Asp Arg Phe Leu Asp Phe
225                 230                 235                 240
Trp Arg Lys Thr Gly Asn Gln His Phe Gly Tyr Leu Tyr Gly Arg Tyr
                245                 250                 255
Thr Glu His Lys Asp Ile Pro Leu Gly Ile Arg Ala Glu Val Ala Ala
            260                 265                 270
Ile Tyr Glu Pro Pro Gln Ile Gly Thr Gln Asn Ser Leu Glu Leu Leu
        275                 280                 285
Glu Asp Pro Lys Ala Glu Val Val Asp Glu Ile Ala Ala Lys Leu Gly
    290                 295                 300
Leu Arg Lys Val Gly Trp Ile Phe Thr Asp Leu Val Ser Glu Asp Thr
305                 310                 315                 320
Arg Lys Gly Thr Val Arg Tyr Ser Arg Asn Lys Asp Thr Tyr Phe Leu
                325                 330                 335
Ser Ser Glu Glu Cys Ile Thr Ala Gly Asp Phe Gln Asn Lys His Pro
            340                 345                 350
Asn Met Cys Arg Leu Ser Pro Asp Gly His Phe Gly Ser Lys Phe Val
        355                 360                 365
Thr Ala Val Ala Thr Gly Gly Pro Asp Asn Gln Val His Phe Glu Gly
    370                 375                 380
Tyr Gln Val Ser Asn Gln Cys Met Ala Leu Val Arg Asp Glu Cys Leu
385                 390                 395                 400
Leu Pro Cys Lys Asp Ala Pro Glu Leu Gly Tyr Ala Lys Glu Ser Ser
                405                 410                 415
Ser Glu Gln Tyr Val Pro Asp Val Phe Tyr Lys Asp Val Asp Lys Phe
            420                 425                 430
Gly Asn Glu Ile Thr Gln Leu Ala Arg Pro Leu Pro Val Glu Tyr Leu
        435                 440                 445
Ile Ile Asp Ile Thr Thr Thr Phe Pro Lys Asp Pro Val Tyr Thr Phe
    450                 455                 460
Ser Ile Ser Gln Asn Pro Phe Pro Ile Glu Asn Arg Asp Val Leu Gly
465                 470                 475                 480
Glu Thr Gln Asp Phe His Ser Leu Ala Thr Tyr Leu Ser Gln Asn Thr
                485                 490                 495
Ser Ser Val Phe Leu Asp Thr Ile Ser Asp Phe His Leu Leu Leu Phe
            500                 505                 510
Leu Val Thr Asn Glu Val Met Pro Leu Gln Asp Ser Ile Ser Leu Leu
        515                 520                 525
Leu Glu Ala Val Arg Thr Arg Asn Glu Glu Leu Ala Gln Thr Trp Lys
    530                 535                 540
Arg Ser Glu Gln Trp Ala Thr Ile Glu Gln Leu Cys Ser Thr Val Gly
545                 550                 555                 560
Gly Gln Leu Pro Gly Leu His Glu Tyr Gly Ala Val Gly Gly Ser Thr
                565                 570                 575
His Thr Ala Thr Ala Ala Met Trp Ala Cys Gln His Cys Thr Phe Met
            580                 585                 590
Asn Gln Pro Gly Thr Gly His Cys Glu Met Cys Ser Leu Pro Arg Thr
        595                 600                 605

<210> 28
<211> 596
<212> PRT
<213> Homo sapiens

<400> 28
Met Gly Arg Gly Ala Arg Ala Ala Ala Ala Gln Ser Arg Trp Gly Arg
 1               5                  10                  15
Ala Ser Arg Ala Ser Val Ser Pro Gly Arg Thr Ile Arg Ser Ala Pro
            20                  25                  30
Ala Val Gly Glu Ala Gln Glu Thr Glu Ala Ala Pro Glu Lys Glu Asn
        35                  40                  45
Arg Val Asp Val Gly Ala Glu Glu Arg Ala Ala Ala Thr Arg Pro Arg
    50                  55                  60
Gln Lys Ser Trp Leu Val Arg His Phe Ser Leu Leu Leu Arg Arg Asp
65                  70                  75                  80
Arg Gln Ala Gln Lys Ala Gly Gln Leu Phe Ser Gly Leu Leu Ala Leu
                85                  90                  95
Asn Val Val Phe Leu Gly Gly Ala Phe Ile Cys Ser Met Ile Phe Asn
            100                 105                 110
Lys Val Ala Val Thr Leu Gly Asp Val Trp Ile Leu Leu Ala Thr Leu
        115                 120                 125
Lys Val Leu Ser Leu Leu Trp Leu Leu Tyr Tyr Val Ala Ser Thr Thr
    130                 135                 140
Arg Arg Pro His Ala Val Leu Tyr Gln Asp Pro His Ala Gly Pro Leu
145                 150                 155                 160
Trp Val Arg Gly Ser Leu Val Leu Phe Gly Ser Cys Thr Phe Cys Leu
                165                 170                 175
Asn Ile Phe Arg Val Gly Tyr Asp Val Ser His Ile Arg Cys Lys Ser
            180                 185                 190
Gln Leu Asp Leu Val Phe Ser Val Ile Glu Met Val Phe Ile Gly Val
        195                 200                 205
Gln Thr Trp Val Leu Trp Lys His Cys Lys Asp Cys Val Arg Val Gln
    210                 215                 220
Thr Asn Phe Thr Arg Cys Gly Leu Met Leu Thr Leu Ala Thr Asn Leu
225                 230                 235                 240
Leu Leu Trp Val Leu Ala Val Thr Asn Asp Ser Met His Arg Glu Ile
                245                 250                 255
Glu Ala Glu Leu Gly Ile Leu Met Glu Lys Ser Thr Gly Asn Glu Thr
            260                 265                 270
Asn Thr Cys Leu Cys Leu Asn Ala Thr Ala Cys Glu Ala Phe Arg Arg
        275                 280                 285
Gly Phe Leu Met Leu Tyr Pro Phe Ser Thr Glu Tyr Cys Leu Ile Cys
    290                 295                 300
Cys Ala Val Leu Phe Val Met Trp Lys Asn Val Gly Arg His Val Ala
305                 310                 315                 320
Pro His Met Gly Ala His Pro Ala Thr Ala Pro Phe His Leu His Gly
                325                 330                 335
Ala Ile Phe Gly Pro Leu Leu Gly Leu Leu Val Leu Leu Ala Gly Val
            340                 345                 350
Cys Val Phe Val Leu Phe Gln Ile Glu Ala Ser Gly Pro Ala Ile Ala
        355                 360                 365
Cys Gln Tyr Phe Thr Leu Tyr Tyr Ala Phe Tyr Val Ala Val Leu Pro
    370                 375                 380
Thr Met Ser Leu Ala Cys Leu Ala Gly Thr Ala Ile His Gly Leu Glu
385                 390                 395                 400
Glu Arg Glu Leu Asp Thr Val Lys Asn Pro Thr Arg Ser Leu Asp Val
                405                 410                 415
Val Leu Leu Met Gly Ala Ala Leu Gly Gln Met Gly Ile Ala Tyr Phe
            420                 425                 430
Ser Ile Val Ala Ile Val Ala Lys Arg Pro His Glu Leu Leu Asn Arg
        435                 440                 445
Leu Ile Leu Ala Tyr Ser Leu Leu Leu Ile Leu Gln His Ile Ala Gln
    450                 455                 460
Asn Leu Phe Ile Ile Glu Gly Leu His Arg Arg Pro Leu Trp Glu Thr
465                 470                 475                 480
Val Pro Glu Gly Leu Ala Gly Lys Gln Glu Ala Glu Pro Pro Arg Arg
                485                 490                 495
Gly Ser Leu Leu Glu Leu Gly Gln Gly Leu Gln Arg Ala Ser Leu Ala
            500                 505                 510
Tyr Ile His Ser Tyr Ser His Leu Asn Trp Lys Arg Arg Ala Leu Lys
        515                 520                 525
Glu Ile Ser Leu Phe Leu Ile Leu Cys Asn Ile Thr Leu Trp Met Met
    530                 535                 540
Pro Ala Phe Gly Ile His Pro Glu Phe Glu Asn Gly Leu Glu Lys Asp
545                 550                 555                 560
Phe Tyr Gly Tyr Gln Ile Trp Phe Ala Ile Val Asn Phe Gly Leu Pro
                565                 570                 575
Leu Gly Val Phe Tyr Arg Met His Ser Val Gly Gly Leu Val Glu Val
            580                 585                 590
Tyr Leu Gly Ala
        595

<210> 29
<211> 926
<212> PRT
<213> Homo sapiens

<400> 29
Met Val Ser Ser Val Leu Pro Asn Pro Thr Ser Ala Glu Cys Trp Ala
 1               5                  10                  15
Ala Leu Leu His Asp Pro Met Thr Leu Asp Met Asp Ala Val Leu Ser
            20                  25                  30
Asp Phe Val Arg Ser Thr Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu
        35                  40                  45
Leu Glu Gly Lys Asn Trp Asp Leu Thr Ala Ala Leu Ser Asp Tyr Glu
    50                  55                  60
Gln Leu Arg Gln Val His Thr Ala Asn Leu Pro His Val Phe Asn Glu
65                  70                  75                  80
Gly Arg Gly Pro Lys Gln Pro Glu Arg Glu Pro Gln Pro Gly His Lys
                85                  90                  95
Val Glu Arg Pro Cys Leu Gln Arg Gln Asp Asp Ile Ala Gln Glu Lys
            100                 105                 110
Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ala Ile Val Ser Leu
        115                 120                 125
Ala Arg Ser His Val Ala Ser Glu Cys Asn Asn Glu Gln Phe Pro Leu
    130                 135                 140
Glu Met Pro Ile Tyr Thr Phe Gln Leu Pro Asp Leu Ser Val Tyr Ser
145                 150                 155                 160
Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ala Thr
                165                 170                 175
Met Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Ser Thr Val
            180                 185                 190
Cys Thr Ser Cys Lys Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly
        195                 200                 205
Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp
    210                 215                 220
Arg Asp Leu Val Leu Arg Lys Ala Leu Tyr Thr Met Met Arg Thr Gly
225                 230                 235                 240
Ala Glu Arg Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln
                245                 250                 255
Gln Asn Lys Glu Glu Glu Trp Glu Arg Glu Trp Thr Glu Leu Leu Lys
            260                 265                 270
Leu Ala Ser Ser Glu Pro Arg Thr His Phe Ser Lys Asn Gly Gly Thr
        275                 280                 285
Gly Gly Gly Val Asp Asn Ser Glu Asp Pro Val Tyr Glu Ser Leu Glu
    290                 295                 300
Glu Phe His Val Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Val
305                 310                 315                 320
Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala
                325                 330                 335
Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Pro Asn
            340                 345                 350
Arg Cys His Cys Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe
        355                 360                 365
Ser Ala Leu Val Ser Met Glu Gln Arg Asp Gln Gln Arg Glu Gln Ala
    370                 375                 380
Val Ile Pro Leu Thr Asp Ser Glu His Lys Leu Leu Pro Leu His Phe
385                 390                 395                 400
Ala Val Asp Pro Gly Lys Asp Trp Glu Trp Gly Lys Asp Asp Asn Asp
                405                 410                 415
Asn Ala Arg Leu Ala His Leu Ile Leu Ser Leu Glu Ala Lys Leu Asn
            420                 425                 430
Leu Leu His Ser Tyr Met Asn Val Thr Trp Ile Arg Ile Pro Ser Glu
        435                 440                 445
Thr Arg Ala Pro Leu Ala Gln Pro Glu Ser Pro Thr Ala Ser Ala Gly
    450                 455                 460
Glu Asp Val Gln Ser Leu Ala Asp Ser Leu Asp Ser Asp Arg Asp Ser
465                 470                 475                 480
Val Cys Ser Asn Ser Asn Ser Asn Asn Gly Lys Asn Gly Lys Asp Lys
                485                 490                 495
Glu Lys Glu Lys Gln Arg Lys Glu Lys Asp Lys Thr Arg Ala Asp Ser
            500                 505                 510
Val Ala Asn Lys Leu Gly Ser Phe Ser Lys Thr Leu Gly Ile Lys Leu
        515                 520                 525
Lys Lys Asn Met Gly Gly Leu Gly Gly Leu Val His Gly Lys Met Gly
    530                 535                 540
Arg Ala Asn Ser Ala Asn Gly Lys Asn Gly Asp Ser Ala Glu Arg Gly
545                 550                 555                 560
Lys Glu Lys Lys Ala Lys Ser Arg Lys Gly Ser Lys Glu Glu Ser Gly
                565                 570                 575
Ala Ser Ala Ser Thr Ser Pro Ser Glu Lys Thr Thr Pro Ser Pro Thr
            580                 585                 590
Asp Lys Ala Ala Gly Ala Ser Pro Ala Glu Lys Gly Gly Gly Pro Arg
        595                 600                 605
Gly Asp Ala Trp Lys Tyr Ser Thr Asp Val Lys Leu Ser Leu Asn Ile
    610                 615                 620
Leu Arg Ala Ala Met Gln Gly Glu Arg Lys Phe Ile Phe Ala Gly Leu
625                 630                 635                 640
Leu Leu Thr Ser His Arg His Gln Phe His Glu Glu Met Ile Gly Tyr
                645                 650                 655
Tyr Leu Thr Ser Ala Gln Glu Arg Phe Ser Ala Glu Gln Glu Gln Arg
            660                 665                 670
Arg Arg Asp Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
        675                 680                 685
Ala Thr Ala Lys Arg Pro Pro Arg Arg Pro Glu Thr Glu Gly Val Pro
    690                 695                 700
Val Pro Glu Arg Ala Ser Pro Gly Pro Pro Thr Gln Leu Val Leu Lys
705                 710                 715                 720
Leu Lys Glu Arg Pro Ser Pro Gly Pro Ala Ala Gly Arg Ala Ala Arg
                725                 730                 735
Ala Ala Ala Gly Gly Thr Ala Ser Pro Gly Gly Gly Ala Arg Arg Ala
            740                 745                 750
Ser Ala Ser Gly Pro Val Pro Gly Arg Ser Pro Pro Ala Pro Ala Arg
        755                 760                 765
Gln Ser Val Ile His Val Gln Ala Ser Gly Ala Arg Asp Glu Ala Cys
    770                 775                 780
Ala Pro Ala Val Gly Ala Leu Arg Pro Cys Ala Thr Tyr Pro Gln Gln
785                 790                 795                 800
Asn Arg Ser Leu Ser Ser Gln Ser Tyr Ser Pro Ala Arg Ala Ala Ala
                805                 810                 815
Leu Arg Thr Val Asn Thr Val Glu Ser Leu Ala Arg Ala Val Pro Gly
            820                 825                 830
Ala Leu Pro Gly Ala Ala Gly Thr Ala Gly Ala Ala Glu His Lys Ser
        835                 840                 845
Gln Thr Tyr Thr Asn Gly Phe Gly Ala Leu Arg Asp Gly Leu Glu Phe
    850                 855                 860
Ala Asp Ala Asp Ala Pro Thr Ala Arg Ser Asn Gly Glu Cys Gly Arg
865                 870                 875                 880
Gly Gly Pro Gly Pro Val Gln Arg Arg Cys Gln Arg Glu Asn Cys Ala
                885                 890                 895
Phe Tyr Gly Arg Ala Glu Thr Glu His Tyr Cys Ser Tyr Cys Tyr Arg
            900                 905                 910
Glu Glu Leu Arg Arg Arg Arg Glu Ala Arg Gly Ala Arg Pro
        915                 920                 925

<210> 30
<211> 1141
<212> PRT
<213> Homo sapiens

<400> 30
Met Ala Val Pro Gly Asp Ala Ala Arg Val Arg Asp Lys Pro Val His
 1               5                  10                  15
Ser Gly Val Ser Gln Ala Pro Thr Ala Gly Arg Asp Cys His His Arg
            20                  25                  30
Ala Asp Pro Ala Ser Pro Arg Asp Ser Gly Cys Arg Gly Cys Trp Gly
        35                  40                  45
Asp Leu Val Leu Gln Pro Leu Arg Ser Ser Arg Lys Leu Ser Ser Ala
    50                  55                  60
Leu Cys Ala Gly Ser Leu Ser Phe Leu Leu Ala Leu Leu Val Arg Leu
65                  70                  75                  80
Val Arg Gly Glu Val Gly Cys Asp Leu Glu Gln Cys Lys Glu Ala Ala
                85                  90                  95
Ala Ala Glu Glu Glu Glu Ala Ala Pro Gly Ala Glu Gly Gly Val Phe
            100                 105                 110
Pro Gly Pro Arg Gly Gly Ala Pro Gly Gly Gly Ala Arg Leu Ser Pro
        115                 120                 125
Trp Leu Gln Pro Ser Ala Leu Leu Phe Ser Leu Leu Cys Ala Phe Phe
    130                 135                 140
Trp Met Gly Leu Tyr Leu Leu Arg Ala Gly Val Arg Leu Pro Leu Ala
145                 150                 155                 160
Val Ala Leu Leu Ala Ala Cys Cys Gly Gly Glu Ala Leu Val Gln Ile
                165                 170                 175
Gly Leu Gly Val Gly Glu Asp His Leu Leu Ser Leu Pro Ala Ala Gly
            180                 185                 190
Val Val Leu Ser Cys Leu Ala Ala Ala Thr Trp Leu Val Leu Arg Leu
        195                 200                 205
Arg Leu Gly Val Leu Met Ile Ala Leu Thr Ser Ala Val Arg Thr Val
    210                 215                 220
Ser Leu Ile Ser Leu Glu Arg Phe Lys Val Ala Trp Arg Pro Tyr Leu
225                 230                 235                 240
Ala Tyr Leu Ala Gly Val Leu Gly Ile Leu Leu Ala Arg Tyr Val Glu
                245                 250                 255
Gln Ile Leu Pro Gln Ser Ala Glu Ala Ala Pro Arg Glu His Leu Gly
            260                 265                 270
Ser Gln Leu Ile Ala Gly Thr Lys Glu Asp Ile Pro Val Phe Lys Arg
        275                 280                 285
Arg Arg Arg Ser Ser Ser Val Val Ser Ala Glu Met Ser Gly Cys Ser
    290                 295                 300
Ser Lys Ser His Arg Arg Thr Ser Leu Pro Cys Ile Pro Arg Glu Gln
305                 310                 315                 320
Leu Met Gly His Ser Glu Trp Asp His Lys Arg Gly Pro Arg Gly Ser
                325                 330                 335
Gln Ser Ser Gly Thr Ser Ile Thr Val Asp Ile Ala Val Met Gly Glu
            340                 345                 350
Ala His Gly Leu Ile Thr Asp Leu Leu Ala Asp Pro Ser Leu Pro Pro
        355                 360                 365
Asn Val Cys Thr Ser Leu Arg Ala Val Ser Asn Leu Leu Ser Thr Gln
    370                 375                 380
Leu Thr Phe Gln Ala Ile His Lys Pro Arg Val Asn Pro Val Thr Ser
385                 390                 395                 400
Leu Ser Glu Asn Tyr Thr Cys Ser Asp Ser Glu Glu Ser Ser Glu Lys
                405                 410                 415
Asp Lys Leu Ala Ile Pro Lys Arg Leu Arg Arg Ser Leu Pro Pro Gly
            420                 425                 430
Leu Leu Arg Arg Val Ser Ser Thr Trp Thr Thr Thr Thr Ser Ala Thr
        435                 440                 445
Gly Leu Pro Thr Leu Glu Pro Ala Pro Val Arg Arg Asp Arg Ser Thr
    450                 455                 460
Ser Ile Lys Leu Gln Glu Ala Pro Ser Ser Ser Pro Asp Ser Trp Asn
465                 470                 475                 480
Asn Pro Val Met Met Thr Leu Thr Lys Ser Arg Ser Phe Thr Ser Ser
                485                 490                 495
Tyr Ala Ile Ser Ala Ala Asn His Val Lys Ala Lys Lys Gln Ser Arg
            500                 505                 510
Pro Gly Ala Leu Ala Lys Ile Ser Pro Leu Ser Ser Pro Cys Ser Ser
        515                 520                 525
Pro Leu Gln Gly Thr Pro Ala Ser Ser Leu Val Ser Lys Ile Ser Ala
    530                 535                 540
Val Gln Phe Pro Glu Ser Ala Asp Thr Thr Ala Lys Gln Ser Leu Gly
545                 550                 555                 560
Ser His Arg Ala Leu Thr Tyr Thr Gln Ser Ala Pro Asp Leu Ser Pro
                565                 570                 575
Gln Ile Leu Thr Pro Pro Val Ile Cys Ser Ser Cys Gly Arg Pro Tyr
            580                 585                 590
Ser Gln Gly Asn Pro Ala Asp Glu Pro Leu Glu Arg Ser Gly Val Ala
        595                 600                 605
Thr Arg Thr Pro Ser Arg Thr Asp Asp Thr Ala Gln Val Thr Ser Asp
    610                 615                 620
Tyr Glu Thr Asn Asn Asn Ser Asp Ser Ser Asp Ile Val Gln Asn Glu
625                 630                 635                 640
Asp Glu Thr Glu Cys Leu Arg Glu Pro Leu Arg Lys Ala Ser Ala Cys
                645                 650                 655
Ser Thr Tyr Ala Pro Glu Thr Met Met Phe Leu Asp Lys Pro Ile Leu
            660                 665                 670
Ala Pro Glu Pro Leu Val Met Asp Asn Leu Asp Ser Ile Met Glu Gln
        675                 680                 685
Leu Asn Thr Trp Asn Phe Pro Ile Phe Asp Leu Val Glu Asn Ile Gly
    690                 695                 700
Arg Lys Cys Gly Arg Ile Leu Ser Gln Val Ser Tyr Arg Leu Phe Glu
705                 710                 715                 720
Asp Met Gly Leu Phe Glu Ala Phe Lys Ile Pro Ile Arg Glu Phe Met
                725                 730                 735
Asn Tyr Phe His Ala Leu Glu Ile Gly Tyr Arg Asp Ile Pro Tyr His
            740                 745                 750
Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu Thr
        755                 760                 765
Thr Gln Pro Ile Pro Gly Leu Ser Thr Val Ile Asn Asp His Gly Ser
    770                 775                 780
Thr Ser Asp Ser Asp Ser Asp Ser Gly Phe Thr His Gly His Met Gly
785                 790                 795                 800
Tyr Val Phe Ser Lys Thr Tyr Asn Val Thr Asp Asp Lys Tyr Gly Cys
                805                 810                 815
Leu Ser Gly Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val Ala
            820                 825                 830
Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe Leu
        835                 840                 845
Val Ala Thr Ser Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser Val
    850                 855                 860
Leu Glu Asn His His Ala Ala Ala Ala Trp Asn Leu Phe Met Ser Arg
865                 870                 875                 880
Pro Glu Tyr Asn Phe Leu Ile Asn Leu Asp His Val Glu Phe Lys His
                885                 890                 895
Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys Lys
            900                 905                 910
His Phe Asp Phe Val Ala Lys Phe Asn Gly Lys Val Asn Asp Asp Val
        915                 920                 925
Gly Ile Asp Trp Thr Asn Glu Asn Asp Arg Leu Leu Val Cys Gln Met
    930                 935                 940
Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Cys Lys Glu Leu
945                 950                 955                 960
His Leu Gln Trp Thr Asp Gly Ile Val Asn Glu Phe Tyr Glu Gln Gly
                965                 970                 975
Asp Glu Glu Ala Ser Leu Gly Leu Pro Ile Ser Pro Phe Met Asp Arg
            980                 985                 990
Ser Ala Pro Gln Leu Ala Asn Leu Gln Glu Ser Phe Ile Ser His Ile
        995                 1000                1005
Val Gly Pro Leu Cys Asn Ser Tyr Asp Ser Ala Gly Leu Met Pro Gly
    1010                1015                1020
Lys Trp Val Glu Asp Ser Asp Glu Ser Gly Asp Thr Asp Asp Pro Glu
1025                1030                1035                1040
Glu Glu Glu Glu Glu Ala Pro Ala Pro Asn Glu Glu Glu Thr Cys Glu
                1045                1050                1055
Asn Asn Glu Ser Pro Lys Lys Lys Thr Phe Lys Arg Arg Lys Ile Tyr
            1060                1065                1070
Cys Gln Ile Thr Gln His Leu Leu Gln Asn His Lys Met Trp Lys Lys
        1075                1080                1085
Val Ile Glu Glu Glu Gln Arg Leu Ala Gly Ile Glu Asn Gln Ser Leu
    1090                1095                1100
Asp Gln Thr Pro Gln Ser His Ser Ser Glu Gln Ile Gln Ala Ile Lys
1105                1110                1115                1120
Glu Glu Glu Glu Glu Lys Gly Lys Pro Arg Gly Glu Glu Ile Pro Thr
                1125                1130                1135
Gln Lys Pro Asp Gln
            1140

<210> 31
<211> 870
<212> PRT
<213> Homo sapiens

<400> 31
Met Asp Ser Thr Lys Glu Lys Cys Asp Ser Tyr Lys Asp Asp Leu Leu
 1               5                  10                  15
Leu Arg Met Gly Leu Asn Asp Asn Lys Ala Gly Met Glu Gly Leu Asp
            20                  25                  30
Lys Glu Lys Ile Asn Lys Ile Ile Met Glu Ala Thr Lys Gly Ser Arg
        35                  40                  45
Phe Tyr Gly Asn Glu Leu Lys Lys Glu Lys Gln Val Asn Gln Arg Ile
    50                  55                  60
Glu Asn Met Met Gln Gln Lys Ala Gln Ile Thr Ser Gln Gln Leu Arg
65                  70                  75                  80
Lys Ala Gln Leu Gln Val Asp Arg Phe Ala Met Glu Leu Glu Gln Ser
                85                  90                  95
Arg Asn Leu Ser Asn Thr Ile Val His Ile Asp Met Asp Ala Phe Tyr
            100                 105                 110
Ala Ala Val Glu Met Arg Asp Asn Pro Glu Leu Lys Asp Lys Pro Ile
        115                 120                 125
Ala Val Gly Ser Met Ser Met Leu Ser Thr Ser Asn Tyr His Ala Arg
    130                 135                 140
Arg Phe Gly Val Arg Ala Ala Met Pro Gly Phe Ile Ala Lys Arg Leu
145                 150                 155                 160
Cys Pro Gln Leu Ile Ile Val Pro Pro Asn Phe Asp Lys Tyr Arg Ala
                165                 170                 175
Val Ser Lys Glu Val Lys Glu Ile Leu Ala Asp Tyr Asp Pro Asn Phe
            180                 185                 190
Met Ala Met Ser Leu Asp Glu Ala Tyr Leu Asn Ile Thr Lys His Leu
        195                 200                 205
Glu Glu Arg Gln Asn Trp Pro Glu Asp Lys Arg Arg Tyr Phe Ile Lys
    210                 215                 220
Met Gly Ser Ser Val Glu Asn Asp Asn Pro Gly Lys Glu Val Asn Lys
225                 230                 235                 240
Leu Ser Glu His Glu Arg Ser Ile Ser Pro Leu Leu Phe Glu Glu Ser
                245                 250                 255
Pro Ser Asp Val Gln Pro Pro Gly Asp Pro Phe Gln Val Asn Phe Glu
            260                 265                 270
Glu Gln Asn Asn Pro Gln Ile Leu Gln Asn Ser Val Val Phe Gly Thr
        275                 280                 285
Ser Ala Gln Glu Val Val Lys Glu Ile Arg Phe Arg Ile Glu Gln Lys
    290                 295                 300
Thr Thr Leu Thr Ala Ser Ala Gly Ile Ala Pro Asn Thr Met Leu Ala
305                 310                 315                 320
Lys Val Cys Ser Asp Lys Asn Lys Pro Asn Gly Gln Tyr Gln Ile Leu
                325                 330                 335
Pro Asn Arg Gln Ala Val Met Asp Phe Ile Lys Asp Leu Pro Ile Arg
            340                 345                 350
Lys Val Ser Gly Ile Gly Lys Val Thr Glu Lys Met Leu Lys Ala Leu
        355                 360                 365
Gly Ile Ile Thr Cys Thr Glu Leu Tyr Gln Gln Arg Ala Leu Leu Ser
    370                 375                 380
Leu Leu Phe Ser Glu Thr Ser Trp His Tyr Phe Leu His Ile Ser Leu
385                 390                 395                 400
Gly Leu Gly Ser Thr His Leu Thr Arg Asp Gly Glu Arg Lys Ser Met
                405                 410                 415
Ser Val Glu Arg Thr Phe Ser Glu Ile Asn Lys Ala Glu Glu Gln Tyr
            420                 425                 430
Ser Leu Cys Gln Glu Leu Cys Ser Glu Leu Ala Gln Asp Leu Gln Lys
        435                 440                 445
Glu Arg Leu Lys Gly Arg Thr Val Thr Ile Lys Leu Lys Asn Val Asn
    450                 455                 460
Phe Glu Val Lys Thr Arg Ala Ser Thr Val Ser Ser Val Val Ser Thr
465                 470                 475                 480
Ala Glu Glu Ile Phe Ala Ile Ala Lys Glu Leu Leu Lys Thr Glu Ile
                485                 490                 495
Asp Ala Asp Phe Pro His Pro Leu Arg Leu Arg Leu Met Gly Val Arg
            500                 505                 510
Ile Ser Ser Phe Pro Asn Glu Glu Asp Arg Lys His Gln Gln Arg Ser
        515                 520                 525
Ile Ile Gly Phe Leu Gln Ala Gly Asn Gln Ala Leu Ser Ala Thr Glu
    530                 535                 540
Cys Thr Leu Glu Lys Thr Asp Lys Asp Lys Phe Val Lys Pro Leu Glu
545                 550                 555                 560
Met Ser His Lys Lys Ser Phe Phe Asp Lys Lys Arg Ser Glu Arg Lys
                565                 570                 575
Trp Ser His Gln Asp Thr Phe Lys Cys Glu Ala Val Asn Lys Gln Ser
            580                 585                 590
Phe Gln Thr Ser Gln Pro Phe Gln Val Leu Lys Lys Lys Met Asn Glu
        595                 600                 605
Asn Leu Glu Ile Ser Glu Asn Ser Asp Asp Cys Gln Ile Leu Thr Cys
    610                 615                 620
Pro Val Cys Phe Arg Ala Gln Gly Cys Ile Ser Leu Glu Ala Leu Asn
625                 630                 635                 640
Lys His Val Asp Glu Cys Leu Asp Gly Pro Ser Ile Ser Glu Asn Phe
                645                 650                 655
Lys Met Phe Ser Cys Ser His Val Ser Ala Thr Lys Val Asn Lys Lys
            660                 665                 670
Glu Asn Val Pro Ala Ser Ser Leu Cys Glu Lys Gln Asp Tyr Glu Ala
        675                 680                 685
His Pro Lys Ile Lys Glu Ile Ser Ser Val Asp Cys Ile Ala Leu Val
    690                 695                 700
Asp Thr Ile Asp Asn Ser Ser Lys Ala Glu Ser Ile Asp Ala Leu Ser
705                 710                 715                 720
Asn Lys His Ser Lys Glu Glu Cys Ser Ser Leu Pro Ser Lys Ser Phe
                725                 730                 735
Asn Ile Glu His Cys His Gln Asn Ser Ser Ser Thr Val Ser Leu Glu
            740                 745                 750
Asn Glu Asp Val Gly Ser Phe Arg Gln Glu Tyr Arg Gln Pro Tyr Leu
        755                 760                 765
Cys Glu Val Lys Thr Gly Gln Ala Leu Val Cys Pro Val Cys Asn Val
    770                 775                 780
Glu Gln Lys Thr Ser Asp Leu Thr Leu Phe Asn Val His Val Asp Val
785                 790                 795                 800
Cys Leu Asn Lys Ser Phe Ile Gln Glu Leu Arg Lys Asp Lys Phe Asn
                805                 810                 815
Pro Val Asn Gln Pro Lys Glu Ser Ser Arg Ser Thr Gly Ser Ser Ser
            820                 825                 830
Gly Val Gln Lys Ala Val Thr Arg Thr Lys Arg Pro Gly Leu Met Thr
        835                 840                 845
Lys Tyr Ser Thr Ser Lys Lys Ile Lys Pro Asn Asn Pro Lys His Thr
    850                 855                 860
Leu Asp Ile Phe Phe Lys
865                 870

<210> 32
<211> 57
<212> PRT
<213> Homo sapiens

<400> 32
Met Leu Cys Ala His Phe Ser Asp Gln Gly Pro Ala His Leu Thr Thr
 1               5                  10                  15
Ser Lys Ser Ala Phe Leu Ser Asn Lys Lys Thr Ser Thr Leu Lys His
            20                  25                  30
Leu Leu Gly Glu Thr Arg Ser Asp Gly Ser Ala Cys Asn Ser Gly Ile
        35                  40                  45
Ser Gly Gly Arg Gly Arg Lys Ile Pro
    50                  55

<210> 33
<211> 418
<212> PRT
<213> Homo sapiens

<400> 33
Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His
 1               5                  10                  15
Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp
            20                  25                  30
Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys
        35                  40                  45
Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp
    50                  55                  60
Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu
65                  70                  75                  80
Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala
                85                  90                  95
Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu
            100                 105                 110
Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr
        115                 120                 125
Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe
    130                 135                 140
Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys
145                 150                 155                 160
Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp
                165                 170                 175
Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu
            180                 185                 190
Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu
        195                 200                 205
Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg
    210                 215                 220
Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg
225                 230                 235                 240
Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp
                245                 250                 255
Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met
            260                 265                 270
Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu
        275                 280                 285
Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu
    290                 295                 300
Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser
305                 310                 315                 320
Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser
                325                 330                 335
Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys
            340                 345                 350
Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly
        355                 360                 365
Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe
    370                 375                 380
Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp
385                 390                 395                 400
Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg
                405                 410                 415
Gly Pro


<210> 34
<211> 353
<212> PRT
<213> Homo sapiens

<400> 34
Met Pro Ser Pro Val Gly Leu Leu Arg Ala Leu Pro Leu Pro Trp Pro
 1               5                  10                  15
Gln Phe Leu Ala Cys Thr Leu Arg Arg Leu Ala Gly Pro Arg Glu Ser
            20                  25                  30
Thr Gly Pro Ser Gln Lys Pro Pro Pro Leu Cys Ser Val Pro Cys Arg
        35                  40                  45
Val Pro Ala Met Thr Glu Glu Val Ala Arg Glu Ala Leu Leu Ser Phe
    50                  55                  60
Val Asp Ser Lys Cys Cys Tyr Ser Ser Thr Val Ala Gly Asp Leu Val
65                  70                  75                  80
Ile Gln Glu Leu Lys Arg Gln Thr Leu Cys Arg Tyr Arg Leu Glu Thr
                85                  90                  95
Phe Ser Glu Ser Arg Ile Ser Glu Trp Thr Phe Gln Pro Phe Thr Asn
            100                 105                 110
His Ser Val Asp Gly Pro Gln Arg Gly Ala Ser Pro Arg Leu Trp Asp
        115                 120                 125
Ile Lys Val Gln Gly Pro Pro Met Phe Gln Glu Asp Thr Arg Lys Phe
    130                 135                 140
Gln Val Pro His Ser Ser Leu Val Lys Glu Cys His Lys Cys His Gly
145                 150                 155                 160
Arg Gly Arg Tyr Lys Cys Ser Gly Cys His Gly Ala Gly Thr Val Arg
                165                 170                 175
Cys Pro Ser Cys Cys Gly Ala Lys Arg Lys Ala Lys Gln Ser Arg Arg
            180                 185                 190
Cys Gln Leu Cys Ala Gly Ser Gly Arg Arg Arg Cys Ser Thr Cys Ser
        195                 200                 205
Gly Arg Gly Asn Lys Thr Cys Ala Thr Cys Lys Gly Glu Lys Lys Leu
    210                 215                 220
Leu His Phe Ile Gln Leu Val Ile Met Trp Lys Asn Ser Leu Phe Glu
225                 230                 235                 240
Phe Val Ser Glu His Arg Leu Asn Cys Pro Arg Glu Leu Leu Ala Lys
                245                 250                 255
Ala Lys Gly Glu Asn Leu Phe Lys Asp Glu Asn Ser Val Val Tyr Pro
            260                 265                 270
Ile Val Asp Phe Pro Leu Arg Asp Ile Ser Leu Ala Ser Gln Arg Gly
        275                 280                 285
Ile Ala Glu His Ser Ala Ala Leu Ala Ser Arg Ala Arg Val Leu Gln
    290                 295                 300
Gln Arg Gln Thr Ile Glu Leu Ile Pro Leu Thr Glu Val His Tyr Trp
305                 310                 315                 320
Tyr Gln Gly Lys Thr Tyr Val Tyr Tyr Ile Tyr Gly Thr Asp His Gln
                325                 330                 335
Val Tyr Ala Val Asp Tyr Pro Glu Arg Tyr Cys Cys Gly Cys Thr Ile
            340                 345                 350
Val


<210> 35
<211> 202
<212> PRT
<213> Homo sapiens

<400> 35
Met Cys Thr Gly Gly Cys Ala Arg Cys Leu Gly Gly Thr Leu Ile Pro
 1               5                  10                  15
Leu Ala Phe Phe Gly Phe Leu Ala Asn Ile Leu Leu Phe Phe Pro Gly
            20                  25                  30
Gly Lys Val Ile Asp Asp Asn Asp His Leu Ser Gln Glu Ile Trp Phe
        35                  40                  45
Phe Gly Gly Ile Leu Gly Ser Gly Val Leu Met Ile Phe Pro Ala Leu
    50                  55                  60
Val Phe Leu Gly Leu Lys Asn Asn Asp Cys Cys Gly Cys Cys Gly Asn
65                  70                  75                  80
Glu Gly Cys Gly Lys Arg Phe Ala Met Phe Thr Ser Thr Ile Phe Ala
                85                  90                  95
Val Val Gly Phe Leu Gly Ala Gly Tyr Ser Phe Ile Ile Ser Ala Ile
            100                 105                 110
Ser Ile Asn Lys Gly Pro Lys Cys Leu Met Ala Asn Ser Thr Trp Gly
        115                 120                 125
Tyr Pro Phe His Asp Gly Asp Tyr Leu Asn Asp Glu Ala Leu Trp Asn
    130                 135                 140
Lys Cys Arg Glu Pro Leu Asn Val Val Pro Trp Asn Leu Thr Leu Phe
145                 150                 155                 160
Ser Ile Leu Leu Val Val Gly Gly Ile Gln Met Val Leu Cys Ala Ile
                165                 170                 175
Gln Val Val Asn Gly Leu Leu Gly Thr Leu Cys Gly Asp Cys Gln Cys
            180                 185                 190
Cys Gly Cys Cys Gly Gly Asp Gly Pro Val
        195                 200

<210> 36
<211> 1499
<212> PRT
<213> Homo sapiens

<400> 36
Met Glu Arg Glu Pro Ala Gly Thr Glu Glu Pro Gly Pro Pro Gly Arg
 1               5                  10                  15
Arg Arg Arg Arg Glu Gly Arg Thr Arg Thr Val Arg Ser Asn Leu Leu
            20                  25                  30
Pro Pro Pro Gly Ala Glu Asp Pro Ala Ala Gly Ala Ala Lys Gly Glu
        35                  40                  45
Arg Arg Arg Arg Arg Gly Cys Ala Gln His Leu Ala Asp Asn Arg Leu
    50                  55                  60
Lys Thr Thr Lys Tyr Thr Leu Leu Ser Phe Leu Pro Lys Asn Leu Phe
65                  70                  75                  80
Glu Gln Phe His Arg Pro Ala Asn Val Tyr Phe Val Phe Ile Ala Leu
                85                  90                  95
Leu Asn Phe Val Pro Ala Val Asn Ala Phe Gln Pro Gly Leu Ala Leu
            100                 105                 110
Ala Pro Val Leu Phe Ile Leu Ala Ile Thr Ala Phe Arg Asp Leu Trp
        115                 120                 125
Glu Asp Tyr Ser Arg His Arg Ser Asp His Lys Ile Asn His Leu Gly
    130                 135                 140
Cys Leu Val Phe Ser Arg Glu Glu Lys Lys Tyr Val Asn Arg Phe Trp
145                 150                 155                 160
Lys Glu Ile His Val Gly Asp Phe Val Arg Leu Arg Cys Asn Glu Ile
                165                 170                 175
Phe Pro Ala Asp Ile Leu Leu Leu Ser Ser Ser Asp Pro Asp Gly Leu
            180                 185                 190
Cys His Ile Glu Thr Ala Asn Leu Asp Gly Glu Thr Asn Leu Lys Arg
        195                 200                 205
Arg Gln Val Val Arg Gly Phe Ser Glu Leu Val Ser Glu Phe Asn Pro
    210                 215                 220
Leu Thr Phe Thr Ser Val Ile Glu Cys Glu Lys Pro Asn Asn Asp Leu
225                 230                 235                 240
Ser Arg Phe Arg Gly Cys Ile Ile His Asp Asn Gly Lys Lys Ala Gly
                245                 250                 255
Leu Tyr Lys Glu Asn Leu Leu Leu Arg Gly Cys Thr Leu Arg Asn Thr
            260                 265                 270
Asp Ala Val Val Gly Ile Val Ile Tyr Ala Gly His Glu Thr Lys Ala
        275                 280                 285
Leu Leu Asn Asn Ser Gly Pro Arg Tyr Lys Arg Ser Lys Leu Glu Arg
    290                 295                 300
Gln Met Asn Cys Asp Val Leu Trp Cys Val Leu Leu Leu Val Cys Met
305                 310                 315                 320
Ser Leu Phe Ser Ala Val Gly His Gly Leu Trp Ile Trp Arg Tyr Gln
                325                 330                 335
Glu Lys Lys Ser Leu Phe Tyr Val Pro Lys Ser Asp Gly Ser Ser Leu
            340                 345                 350
Ser Pro Val Thr Ala Ala Val Tyr Ser Phe Leu Thr Met Ile Ile Val
        355                 360                 365
Leu Gln Val Leu Ile Pro Ile Ser Leu Tyr Val Ser Ile Glu Ile Val
    370                 375                 380
Lys Ala Cys Gln Val Tyr Phe Ile Asn Gln Asp Met Gln Leu Tyr Asp
385                 390                 395                 400
Glu Glu Thr Asp Ser Gln Leu Gln Cys Arg Ala Leu Asn Ile Thr Glu
                405                 410                 415
Asp Leu Gly Gln Ile Gln Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu
            420                 425                 430
Thr Glu Asn Lys Met Val Phe Arg Arg Cys Thr Val Ser Gly Val Glu
        435                 440                 445
Tyr Ser His Asp Ala Asn Ala Gln Arg Leu Ala Arg Tyr Gln Glu Ala
    450                 455                 460
Asp Ser Glu Glu Glu Glu Val Val Pro Arg Gly Gly Ser Val Ser Gln
465                 470                 475                 480
Arg Gly Ser Ile Gly Ser His Gln Ser Val Arg Val Val His Arg Thr
                485                 490                 495
Gln Ser Thr Lys Ser His Arg Arg Thr Gly Ser Arg Ala Glu Ala Lys
            500                 505                 510
Arg Ala Ser Met Leu Ser Lys His Thr Ala Phe Ser Ser Pro Met Glu
        515                 520                 525
Lys Asp Ile Thr Pro Asp Pro Lys Leu Leu Glu Lys Val Ser Glu Cys
    530                 535                 540
Asp Lys Ser Leu Ala Val Ala Arg His Gln Glu His Leu Leu Ala His
545                 550                 555                 560
Leu Ser Pro Glu Leu Ser Asp Val Phe Asp Phe Phe Ile Ala Leu Thr
                565                 570                 575
Ile Cys Asn Thr Val Val Val Thr Ser Pro Asp Gln Pro Arg Thr Lys
            580                 585                 590
Val Arg Val Arg Phe Glu Leu Lys Ser Pro Val Lys Thr Ile Glu Asp
        595                 600                 605
Phe Leu Arg Arg Phe Thr Pro Ser Cys Leu Thr Ser Gly Cys Ser Ser
    610                 615                 620
Ile Gly Ser Leu Ala Ala Asn Lys Ser Ser His Lys Leu Gly Ser Ser
625                 630                 635                 640
Phe Pro Ser Thr Pro Ser Ser Asp Gly Met Leu Leu Arg Leu Glu Glu
                645                 650                 655
Arg Leu Gly Gln Pro Thr Ser Ala Ile Ala Ser Asn Gly Tyr Ser Ser
            660                 665                 670
Gln Ala Asp Asn Trp Ala Ser Glu Leu Ala Gln Glu Gln Glu Ser Glu
        675                 680                 685
Arg Glu Leu Arg Tyr Glu Ala Glu Ser Pro Asp Glu Ala Ala Leu Val
    690                 695                 700
Tyr Ala Ala Arg Ala Tyr Asn Cys Val Leu Val Glu Arg Leu His Asp
705                 710                 715                 720
Gln Val Ser Val Glu Leu Pro His Leu Gly Arg Leu Thr Phe Glu Leu
                725                 730                 735
Leu His Thr Leu Gly Phe Asp Ser Val Arg Lys Arg Met Ser Val Val
            740                 745                 750
Ile Arg His Pro Leu Thr Asp Glu Ile Asn Val Tyr Thr Lys Gly Ala
        755                 760                 765
Asp Ser Val Val Met Asp Leu Leu Gln Pro Cys Ser Ser Val Asp Ala
    770                 775                 780
Arg Gly Arg His Gln Lys Lys Ile Arg Ser Lys Thr Gln Asn Tyr Leu
785                 790                 795                 800
Asn Val Tyr Ala Ala Glu Gly Leu Arg Thr Leu Cys Ile Ala Lys Arg
                805                 810                 815
Val Leu Ser Lys Glu Glu Tyr Ala Cys Trp Leu Gln Ser His Leu Glu
            820                 825                 830
Ala Glu Ser Ser Leu Glu Asn Ser Glu Glu Leu Leu Phe Gln Ser Ala
        835                 840                 845
Ile Arg Leu Glu Thr Asn Leu His Leu Leu Gly Ala Thr Gly Ile Glu
    850                 855                 860
Asp Arg Leu Gln Asp Gly Val Pro Glu Thr Ile Ser Lys Leu Arg Gln
865                 870                 875                 880
Ala Gly Leu Gln Ile Trp Val Leu Thr Gly Asp Lys Gln Glu Thr Ala
                885                 890                 895
Val Asn Ile Ala Tyr Ala Cys Lys Leu Leu Asp His Asp Glu Glu Val
            900                 905                 910
Ile Thr Leu Asn Ala Thr Ser Gln Glu Ala Cys Ala Ala Leu Leu Asp
        915                 920                 925
Gln Cys Leu Cys Tyr Val Gln Ser Arg Gly Leu Gln Arg Ala Pro Glu
    930                 935                 940
Lys Thr Lys Gly Lys Val Ser Met Arg Phe Ser Ser Leu Cys Pro Pro
945                 950                 955                 960
Ser Thr Ser Thr Ala Ser Gly Arg Arg Pro Ser Leu Val Ile Asp Gly
                965                 970                 975
Arg Ser Leu Ala Tyr Ala Leu Glu Lys Asn Leu Glu Asp Lys Phe Leu
            980                 985                 990
Phe Leu Ala Lys Gln Cys Arg Ser Val Leu Cys Cys Arg Ser Thr Pro
        995                 1000                1005
Leu Gln Lys Ser Met Val Val Lys Leu Val Arg Ser Lys Leu Lys Ala
    1010                1015                1020
Met Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Gln
1025                1030                1035                1040
Val Ala Asp Val Gly Val Gly Ile Ser Gly Gln Glu Gly Met Gln Ala
                1045                1050                1055
Val Met Ala Ser Asp Phe Ala Val Pro Lys Phe Arg Tyr Leu Glu Arg
            1060                1065                1070
Leu Leu Ile Leu His Gly His Trp Cys Tyr Ser Arg Leu Ala Asn Met
        1075                1080                1085
Val Leu Tyr Phe Phe Tyr Lys Asn Thr Met Phe Val Gly Leu Leu Phe
    1090                1095                1100
Trp Phe Gln Phe Phe Cys Gly Phe Ser Ala Ser Thr Met Ile Asp Gln
1105                1110                1115                1120
Trp Tyr Leu Ile Phe Phe Asn Leu Leu Phe Ser Ser Leu Pro Pro Leu
                1125                1130                1135
Val Thr Gly Val Leu Asp Arg Asp Val Pro Ala Asn Val Leu Leu Thr
            1140                1145                1150
Asn Pro Gln Leu Tyr Lys Ser Gly Gln Asn Met Glu Glu Tyr Arg Pro
        1155                1160                1165
Arg Thr Phe Trp Phe Asn Met Ala Asp Ala Ala Phe Gln Ser Leu Val
    1170                1175                1180
Cys Phe Ser Ile Pro Tyr Leu Ala Tyr Tyr Asp Ser Asn Val Asp Leu
1185                1190                1195                1200
Phe Thr Trp Gly Thr Pro Ile Val Thr Ile Ala Leu Leu Thr Phe Leu
                1205                1210                1215
Leu His Leu Gly Ile Glu Thr Lys Thr Trp Thr Trp Leu Asn Trp Ile
            1220                1225                1230
Thr Cys Gly Phe Ser Val Leu Leu Phe Phe Thr Val Ala Leu Ile Tyr
        1235                1240                1245
Asn Ala Ser Cys Ala Thr Cys Tyr Pro Pro Ser Asn Pro Tyr Trp Thr
    1250                1255                1260
Met Gln Ala Leu Leu Gly Asp Pro Val Phe Tyr Leu Thr Cys Leu Met
1265                1270                1275                1280
Thr Pro Val Ala Ala Leu Leu Pro Arg Leu Phe Phe Arg Ser Leu Gln
                1285                1290                1295
Gly Arg Val Phe Pro Thr Gln Leu Gln Leu Ala Arg Gln Leu Thr Arg
            1300                1305                1310
Lys Ser Pro Arg Arg Cys Ser Ala Pro Lys Glu Thr Phe Ala Gln Gly
        1315                1320                1325
Arg Leu Pro Lys Asp Ser Gly Thr Glu His Ser Ser Gly Arg Thr Val
    1330                1335                1340
Lys Thr Ser Val Pro Leu Ser Gln Pro Ser Trp His Thr Gln Gln Pro
1345                1350                1355                1360
Val Cys Ser Leu Glu Ala Ser Gly Glu Pro Ser Thr Val Asp Met Ser
                1365                1370                1375
Met Pro Val Arg Glu His Thr Leu Leu Glu Gly Leu Ser Ala Pro Ala
            1380                1385                1390
Pro Met Ser Ser Ala Pro Gly Glu Ala Val Leu Arg Ser Pro Gly Gly
        1395                1400                1405
Cys Pro Glu Glu Ser Lys Val Arg Ala Ala Ser Thr Gly Arg Val Thr
    1410                1415                1420
Pro Leu Ser Ser Leu Phe Ser Leu Pro Thr Phe Ser Leu Leu Asn Trp
1425                1430                1435                1440
Ile Ser Ser Trp Ser Leu Val Ser Arg Leu Gly Ser Val Leu Gln Phe
                1445                1450                1455
Ser Arg Thr Glu Gln Leu Ala Asp Gly Gln Ala Gly Arg Gly Leu Pro
            1460                1465                1470
Val Gln Pro His Ser Gly Arg Ser Gly Leu Gln Gly Pro Asp His Arg
        1475                1480                1485
Leu Leu Ile Gly Ala Ser Ser Arg Arg Ser Gln
    1490                1495

<210> 37
<211> 80
<212> PRT
<213> Homo sapiens

<400> 37
Met Ser Gln Gln Lys Gln Gln Ser Trp Lys Pro Pro Asn Val Pro Lys
 1               5                  10                  15
Cys Ser Pro Pro Gln Arg Ser Asn Pro Cys Leu Ala Pro Tyr Ser Thr
            20                  25                  30
Pro Cys Gly Ala Pro His Ser Glu Gly Cys His Ser Ser Ser Gln Arg
        35                  40                  45
Pro Glu Val Gln Lys Pro Arg Arg Ala Arg Gln Lys Leu Arg Cys Leu
    50                  55                  60
Ser Arg Gly Thr Thr Tyr His Cys Lys Glu Glu Glu Cys Glu Gly Asp
65                  70                  75                  80

<210> 38
<211> 227
<212> PRT
<213> Homo sapiens

<400> 38
Met Ala Pro Tyr His Ile Arg Lys Tyr Gln Glu Ser Asp Arg Lys Ser
 1               5                  10                  15
Val Val Gly Leu Leu Ser Gly Gly Met Ala Glu His Ala Pro Ala Thr
            20                  25                  30
Phe Arg Arg Leu Leu Lys Leu Pro Arg Thr Leu Ile Leu Leu Leu Gly
        35                  40                  45
Gly Ala Leu Ala Leu Leu Leu Val Ser Gly Ser Trp Ile Leu Ala Leu
    50                  55                  60
Val Phe Ser Leu Ser Leu Leu Pro Ala Leu Trp Phe Leu Ala Lys Lys
65                  70                  75                  80
Pro Trp Thr Arg Tyr Val Asp Ile Ala Leu Arg Thr Asp Met Ser Asp
                85                  90                  95
Ile Thr Lys Ser Tyr Leu Ser Glu Cys Gly Ser Cys Phe Trp Val Ala
            100                 105                 110
Glu Ser Glu Glu Lys Val Val Gly Thr Val Gly Ala Leu Pro Val Asp
        115                 120                 125
Asp Pro Thr Leu Arg Glu Lys Arg Leu Gln Leu Phe His Leu Ser Val
    130                 135                 140
Asp Asn Glu His Arg Gly Gln Gly Ile Ala Lys Ala Leu Val Arg Thr
145                 150                 155                 160
Val Leu Gln Phe Ala Arg Asp Gln Gly Tyr Ser Glu Val Val Leu Asp
                165                 170                 175
Thr Ser Asn Ile Gln Leu Ser Ala Met Gly Leu Tyr Gln Ser Leu Gly
            180                 185                 190
Phe Lys Lys Thr Gly Gln Ser Phe Phe His Val Trp Ala Arg Leu Val
        195                 200                 205
Asp Leu His Thr Val His Phe Ile Tyr His Leu Pro Ser Ala Gln Ala
    210                 215                 220
Gly Arg Leu
225

<210> 39
<211> 150
<212> PRT
<213> Homo sapiens

<400> 39
Met Ser Gly Glu Leu Ser Asn Arg Phe Gln Gly Gly Lys Ala Phe Gly
 1               5                  10                  15
Leu Leu Lys Ala Arg Gln Glu Arg Arg Leu Ala Glu Ile Asn Arg Glu
            20                  25                  30
Phe Leu Cys Asp Gln Lys Tyr Ser Asp Glu Glu Asn Leu Pro Glu Lys
        35                  40                  45
Leu Thr Ala Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Asn Glu
    50                  55                  60
Gly Glu Ile Asp Leu Met Ser Leu Lys Arg Met Met Glu Lys Leu Gly
65                  70                  75                  80
Val Pro Lys Thr His Leu Glu Met Lys Lys Met Ile Ser Glu Val Thr
                85                  90                  95
Gly Gly Val Ser Asp Thr Ile Ser Tyr Arg Asp Phe Val Asn Met Met
            100                 105                 110
Leu Gly Lys Arg Ser Ala Val Leu Lys Leu Val Met Met Phe Glu Gly
        115                 120                 125
Lys Ala Asn Glu Ser Ser Pro Lys Pro Val Gly Pro Pro Pro Glu Arg
    130                 135                 140
Asp Ile Ala Ser Leu Pro
145                 150

<210> 40
<211> 201
<212> PRT
<213> Homo sapiens

<400> 40
Met Thr Glu Lys Ala Pro Glu Pro His Val Glu Glu Asp Asp Asp Asp
 1               5                  10                  15
Glu Leu Asp Ser Lys Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu
            20                  25                  30
Lys Glu Leu Gln Glu Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr
        35                  40                  45
Lys Lys Thr Leu Leu Gly Asp Gly Pro Val Val Thr Asp Pro Lys Ala
    50                  55                  60
Pro Asn Val Val Val Thr Arg Leu Thr Leu Val Cys Glu Ser Ala Pro
65                  70                  75                  80
Gly Pro Ile Thr Met Asp Leu Thr Gly Asp Leu Glu Ala Leu Lys Lys
                85                  90                  95
Glu Thr Ile Val Leu Lys Glu Gly Ser Glu Tyr Arg Val Lys Ile His
            100                 105                 110
Phe Lys Val Asn Arg Asp Ile Val Ser Gly Leu Lys Tyr Val Gln His
        115                 120                 125
Thr Tyr Arg Thr Gly Val Lys Val Asp Lys Ala Thr Phe Met Val Gly
    130                 135                 140
Ser Tyr Gly Pro Arg Pro Glu Glu Tyr Glu Phe Leu Thr Pro Val Glu
145                 150                 155                 160
Glu Ala Pro Lys Gly Met Leu Ala Arg Gly Thr Tyr His Asn Lys Ser
                165                 170                 175
Phe Phe Thr Asp Asp Asp Lys Gln Asp His Leu Ser Trp Glu Trp Asn
            180                 185                 190
Leu Ser Ile Lys Lys Glu Trp Thr Glu
        195                 200

<210> 41
<211> 1417
<212> PRT
<213> Homo sapiens

<400> 41
Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His
 1               5                  10                  15
Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe
            20                  25                  30
Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser
        35                  40                  45
Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp
    50                  55                  60
Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr
65                  70                  75                  80
Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly
                85                  90                  95
Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu
            100                 105                 110
Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val
        115                 120                 125
Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser
    130                 135                 140
Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe
145                 150                 155                 160
Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His
                165                 170                 175
Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn
            180                 185                 190
Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu
        195                 200                 205
Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln
    210                 215                 220
Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp
225                 230                 235                 240
Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp
                245                 250                 255
Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys
            260                 265                 270
Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys
        275                 280                 285
Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser
    290                 295                 300
Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser
305                 310                 315                 320
Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser
                325                 330                 335
Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu
            340                 345                 350
Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu
        355                 360                 365
Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp
    370                 375                 380
Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu
385                 390                 395                 400
Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe
                405                 410                 415
Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro
            420                 425                 430
Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn
        435                 440                 445
Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser
    450                 455                 460
Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser
465                 470                 475                 480
Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu
                485                 490                 495
Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly
            500                 505                 510
Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr
        515                 520                 525
Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu
    530                 535                 540
Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp
545                 550                 555                 560
Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala
                565                 570                 575
Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro
            580                 585                 590
Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu
        595                 600                 605
Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln
    610                 615                 620
Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys
625                 630                 635                 640
His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met
                645                 650                 655
Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln
            660                 665                 670
Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu
        675                 680                 685
Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys
    690                 695                 700
Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile
705                 710                 715                 720
Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr
                725                 730                 735
Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln
            740                 745                 750
Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu
        755                 760                 765
Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr
    770                 775                 780
Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val
785                 790                 795                 800
Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met
                805                 810                 815
Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr
            820                 825                 830
Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu
        835                 840                 845
Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr
    850                 855                 860
Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu
865                 870                 875                 880
Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu
                885                 890                 895
Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly
            900                 905                 910
Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp
        915                 920                 925
Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys
    930                 935                 940
Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe
945                 950                 955                 960
Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu
                965                 970                 975
Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe
            980                 985                 990
Tyr Thr Tyr His Asp Val Thr Arg Leu Lys Arg Leu Ile Met Met Glu
        995                 1000                1005
Lys Asp Gly Asn His His Thr Arg Glu Thr His Phe Asn Asn Leu Tyr
    1010                1015                1020
Ser Met Val His Tyr Cys Glu Asn Ile Thr Glu Cys Arg Arg Ile Gln
1025                1030                1035                1040
Leu Leu Ala Tyr Phe Gly Glu Asn Gly Phe Asn Pro Asp Phe Cys Lys
                1045                1050                1055
Lys His Pro Asp Val Ser Cys Asp Asn Cys Cys Lys Thr Lys Asp Tyr
            1060                1065                1070
Lys Thr Arg Asp Val Thr Asp Asp Val Lys Ser Ile Val Arg Phe Val
        1075                1080                1085
Gln Glu His Ser Ser Ser Gln Gly Met Arg Asn Ile Lys His Val Gly
    1090                1095                1100
Pro Ser Gly Arg Phe Thr Met Asn Met Leu Val Asp Ile Phe Leu Gly
1105                1110                1115                1120
Ser Lys Ser Ala Lys Ile Gln Ser Gly Ile Phe Gly Lys Gly Ser Ala
                1125                1130                1135
Tyr Ser Arg His Asn Ala Glu Arg Leu Phe Lys Lys Leu Ile Leu Asp
            1140                1145                1150
Lys Ile Leu Asp Glu Asp Leu Tyr Ile Asn Ala Asn Asp Gln Ala Ile
        1155                1160                1165
Ala Tyr Val Met Leu Gly Asn Lys Ala Gln Thr Val Leu Asn Gly Asn
    1170                1175                1180
Leu Lys Val Asp Phe Met Glu Thr Glu Asn Ser Ser Ser Val Lys Lys
1185                1190                1195                1200
Gln Lys Ala Leu Val Ala Lys Val Ser Gln Arg Glu Glu Met Val Lys
                1205                1210                1215
Lys Cys Leu Gly Glu Leu Thr Glu Val Cys Lys Ser Leu Gly Lys Val
            1220                1225                1230
Phe Gly Val His Tyr Phe Asn Ile Phe Asn Thr Val Thr Leu Lys Lys
        1235                1240                1245
Leu Ala Glu Ser Leu Ser Ser Asp Pro Glu Val Leu Leu Gln Ile Asp
    1250                1255                1260
Gly Val Thr Glu Asp Lys Leu Glu Lys Tyr Gly Ala Glu Val Ile Ser
1265                1270                1275                1280
Val Leu Gln Lys Tyr Ser Glu Trp Thr Ser Pro Ala Glu Asp Ser Ser
                1285                1290                1295
Pro Gly Ile Ser Leu Ser Ser Ser Arg Gly Pro Gly Arg Ser Ala Ala
            1300                1305                1310
Glu Glu Leu Asp Glu Glu Ile Pro Val Ser Ser His Tyr Phe Ala Ser
        1315                1320                1325
Lys Thr Arg Asn Glu Arg Lys Arg Lys Lys Met Pro Ala Ser Gln Arg
    1330                1335                1340
Ser Lys Arg Arg Lys Thr Ala Ser Ser Gly Ser Lys Ala Lys Gly Gly
1345                1350                1355                1360
Ser Ala Thr Cys Arg Lys Ile Ser Ser Lys Thr Lys Ser Ser Ser Ile
                1365                1370                1375
Ile Gly Ser Ser Ser Ala Ser His Thr Ser Gln Ala Thr Ser Gly Ala
            1380                1385                1390
Asn Ser Lys Leu Gly Ile Met Ala Pro Pro Lys Pro Ile Asn Arg Pro
        1395                1400                1405
Phe Leu Lys Pro Ser Tyr Ala Phe Ser
    1410                1415

<210> 42
<211> 648
<212> PRT
<213> Homo sapiens

<400> 42
Met Glu Ala Lys Phe Leu Ala Ser Ala Leu Ser Phe Leu Ser Ile Phe
 1               5                  10                  15
Leu Ala Ile Tyr Ala Gln Ser Leu Ala Asn Asp Leu Ser Lys Glu Ser
            20                  25                  30
Thr Glu Phe Glu Glu Ser Pro Thr Ile Tyr Tyr Gly Asp Pro Val Val
        35                  40                  45
Asn Leu Gly Gln Pro Phe Ser Ile Thr Cys Ile Ile Pro Ile Thr Asp
    50                  55                  60
Gln Ile His Trp Leu Lys Asn Gly Glu Pro Ile Thr Arg His Asn Leu
65                  70                  75                  80
Arg His Gly Arg Asp Asp His Ala Tyr Val Leu Ser Glu Ser Ala Ile
                85                  90                  95
Glu Gly Glu Lys His Lys Ile Glu Ala His Leu Ser Val Arg His Ala
            100                 105                 110
Leu Lys Val His Glu Gly Arg Tyr Gln Cys Asn Arg Arg Arg Gly Ser
        115                 120                 125
Tyr Ile Leu His Val Arg Asp Pro Lys Gly Val Gly Ala Gly Ala Gly
    130                 135                 140
Glu Pro Thr Glu Ser Gly Tyr Gln Thr Ile Asp Glu Leu Thr Pro Asn
145                 150                 155                 160
Ser Ala Asp Asp Phe Phe Thr Arg Ala Trp Leu Glu Gln Gln Gln Gln
                165                 170                 175
Gln Gln Gln Leu Pro His Gln Ser His Lys Leu His Lys Ser His Leu
            180                 185                 190
Gly Tyr Gly Asn Ala Ser Leu Ser Gly Ser Gln Pro Trp His Pro Ser
        195                 200                 205
Ala Gly Gly Gly Gly Ile His Arg Val Tyr Ser Ala Thr Pro Pro Asp
    210                 215                 220
Phe Pro Pro Pro Arg Leu Asn Leu Leu Glu Gln Thr Val Ala Pro Pro
225                 230                 235                 240
Glu Pro Pro Thr Ile Leu Tyr Asn Pro Asn Pro Thr His Pro Thr Ala
                245                 250                 255
Ser Ala Thr Ala Thr Glu Thr Ser Val Leu Leu Thr Thr Ala His His
            260                 265                 270
His Ala His His Gln Gln Gln Leu Gln Gln Gln Ser Gln His Thr Leu
        275                 280                 285
Asn Ala Phe Gln Leu Pro Leu Pro Pro Arg Pro Asn Pro Gly Gln Asn
    290                 295                 300
Glu Arg Tyr Gln Thr Tyr Ala Pro His Tyr Val Pro Pro Val Val Val
305                 310                 315                 320
Ser Gly Ala Gly Ala Gly Ala Gly Ala Asp Pro Gly Ala Gly Ala Ser
                325                 330                 335
Gly Glu Gln Thr Thr Ile Ser Ala Ala Thr Ser Thr Arg Ala Met Met
            340                 345                 350
Gly Gly Gly Gly Gly Val Ala Gly Ala Gly Phe Ser Ala Gly Ala Ser
        355                 360                 365
Gly Pro Met Leu Gly Ala Gly Gly His Met Leu Met Gly Gly Gln Gly
    370                 375                 380
His Gln Val His Leu Gln His Gln Thr Leu Leu Pro Val Lys Met Asp
385                 390                 395                 400
Lys Leu Val Pro Asn Tyr Asp Asn Ala Glu His Gln Met Lys Phe Tyr
                405                 410                 415
Asp Ile Arg Ser Pro Leu Val Leu Ser Cys Asn Val Lys Asp Gly Thr
            420                 425                 430
Pro Gly Gly Val Leu Ile Trp Lys Lys Asn Gly Thr Ala Val Thr Asp
        435                 440                 445
Val Pro Ser Leu Arg Gly Arg Phe Lys Leu Ile Ala Asp Glu Asn Lys
    450                 455                 460
Phe Ile Ile Asp Lys Thr Asp Thr Asn Asp Asp Gly Lys Tyr Ser Cys
465                 470                 475                 480
Glu Phe Asp Gly Val Ser Lys Glu Ile Glu Val Ile Ala Arg Val Val
                485                 490                 495
Val Arg Val Pro Ser Asn Thr Ala Val Val Glu Gly Glu Lys Met Ser
            500                 505                 510
Val Thr Cys Ser Val Val Gly Thr Lys Pro Glu Leu Thr Trp Thr Phe
        515                 520                 525
Ala Asn Val Thr Leu Thr Asn Ala Thr Asp Arg Phe Ile Leu Lys Pro
    530                 535                 540
Asp Asp Asn Gly Val Pro Asn Ala Ile Leu Thr Leu Asp Asn Val Thr
545                 550                 555                 560
Leu Asp Asp Arg Gly Glu Tyr Lys Cys Ile Gly Arg Asn Ala Ala Asn
                565                 570                 575
Val Tyr Gly Gly Asn Thr Thr Thr Pro Ala Ser Asp Val Thr Thr Val
            580                 585                 590
Arg Val Lys Gly Lys Phe Ala Ala Leu Trp Pro Phe Leu Gly Ile Cys
        595                 600                 605
Ala Glu Val Leu Ile Leu Cys Ile Ile Ile Leu Ile Tyr Glu Lys Arg
    610                 615                 620
Arg Asn Lys Ser Glu Leu Glu Glu Ser Asp Thr Asp Pro Gln Glu Gln
625                 630                 635                 640
Lys Lys Lys Arg Arg Asn Tyr Asp
                645

<210> 43
<211> 525
<212> PRT
<213> Homo sapiens

<400> 43
Met Ala Ala Gly Gly Ser Gly Gly Arg Ala Ser Cys Pro Pro Gly Val
 1               5                  10                  15
Gly Val Gly Pro Gly Thr Gly Gly Ser Pro Gly Pro Ser Ala Asn Ala
            20                  25                  30
Ala Ala Thr Pro Ala Pro Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala
        35                  40                  45
Ala Ala Ala Ala Ala Ala Pro Gly Pro Thr Pro Pro Ala Pro Pro Gly
    50                  55                  60
Pro Gly Thr Asp Ala Gln Ala Ala Gly Ala Glu Arg Ala Glu Glu Ala
65                  70                  75                  80
Ala Gly Pro Gly Ala Ala Ala Leu Gln Arg Glu Ala Ala Tyr Asn Trp
                85                  90                  95
Gln Ala Ser Lys Pro Thr Val Gln Glu Arg Phe Ala Phe Leu Phe Asn
            100                 105                 110
Asn Glu Val Leu Cys Asp Val His Phe Leu Val Gly Lys Gly Leu Ser
        115                 120                 125
Ser Gln Arg Ile Pro Ala His Arg Phe Val Leu Ala Val Gly Ser Ala
    130                 135                 140
Val Phe Asp Ala Met Phe Asn Gly Gly Met Ala Thr Thr Ser Thr Glu
145                 150                 155                 160
Ile Glu Leu Pro Asp Val Glu Pro Ala Ala Phe Leu Ala Leu Leu Lys
                165                 170                 175
Phe Leu Tyr Ser Asp Glu Val Gln Ile Gly Pro Glu Thr Val Met Thr
            180                 185                 190
Thr Leu Tyr Thr Ala Lys Lys Tyr Ala Val Pro Ala Leu Glu Ala His
        195                 200                 205
Cys Val Glu Phe Leu Lys Lys Asn Leu Arg Ala Asp Asn Ala Phe Met
    210                 215                 220
Leu Leu Thr Gln Ala Arg Leu Phe Asp Glu Pro Gln Leu Ala Ser Leu
225                 230                 235                 240
Cys Leu Glu Asn Ile Asp Lys Asn Thr Ala Asp Ala Ile Thr Ala Glu
                245                 250                 255
Gly Phe Thr Asp Ile Asp Leu Asp Thr Leu Val Ala Val Leu Glu Arg
            260                 265                 270
Asp Thr Leu Gly Ile Arg Glu Val Arg Leu Phe Asn Ala Val Val Arg
        275                 280                 285
Trp Ser Glu Ala Glu Cys Gln Arg Gln Gln Leu Gln Val Thr Pro Glu
    290                 295                 300
Asn Arg Arg Lys Val Leu Gly Lys Ala Leu Gly Leu Ile Arg Phe Pro
305                 310                 315                 320
Leu Met Thr Ile Glu Glu Phe Ala Ala Gly Pro Ala Gln Ser Gly Ile
                325                 330                 335
Leu Val Asp Arg Glu Val Val Ser Leu Phe Leu His Phe Thr Val Asn
            340                 345                 350
Pro Lys Pro Arg Val Glu Phe Ile Asp Arg Pro Arg Cys Cys Leu Arg
        355                 360                 365
Gly Lys Glu Cys Ser Ile Asn Arg Phe Gln Gln Val Glu Ser Arg Trp
    370                 375                 380
Gly Tyr Ser Gly Thr Ser Asp Arg Ile Arg Phe Ser Val Asn Lys Arg
385                 390                 395                 400
Ile Phe Val Val Gly Phe Gly Leu Tyr Gly Ser Ile His Gly Pro Thr
                405                 410                 415
Asp Tyr Gln Val Asn Ile Gln Ile Ile His Thr Asp Ser Asn Thr Val
            420                 425                 430
Leu Gly Gln Asn Asp Thr Gly Phe Ser Cys Asp Gly Ser Ala Ser Thr
        435                 440                 445
Phe Arg Val Met Phe Lys Glu Pro Val Glu Val Leu Pro Asn Val Asn
    450                 455                 460
Tyr Thr Ala Cys Ala Thr Leu Lys Gly Pro Asp Ser His Tyr Gly Thr
465                 470                 475                 480
Lys Gly Leu Arg Lys Val Thr His Glu Ser Pro Thr Thr Gly Ala Lys
                485                 490                 495
Thr Cys Phe Thr Phe Cys Tyr Ala Ala Gly Asn Asn Asn Gly Thr Ser
            500                 505                 510
Val Glu Asp Gly Gln Ile Pro Glu Val Ile Phe Tyr Thr
        515                 520                 525

<210> 44
<211> 329
<212> PRT
<213> Homo sapiens

<400> 44
Met Glu Leu His Ile Leu Glu His Arg Leu Gln Val Ala Ser Val Ala
 1               5                  10                  15
Lys Glu Ser Ile Pro Leu Phe Thr Tyr Gly Leu Ile Lys Leu Ala Phe
            20                  25                  30
Leu Ser Ser Lys Thr Arg Cys Lys Phe Phe Ser Leu Thr Glu Thr Pro
        35                  40                  45
Glu Asp Tyr Thr Ile Ile Val Asp Glu Glu Gly Phe Leu Glu Leu Pro
    50                  55                  60
Ser Ser Glu His Leu Ser Val Ala Asp Ala Thr Trp Leu Ala Leu Asn
65                  70                  75                  80
Val Val Ser Gly Gly Gly Ser Phe Ser Ser Ser Gln Pro Ile Gly Val
                85                  90                  95
Thr Lys Ile Ala Lys Ser Val Ile Ala Pro Leu Ala Asp Gln Asn Ile
            100                 105                 110
Ser Val Phe Met Leu Ser Thr Tyr Gln Thr Asp Phe Ile Leu Val Arg
        115                 120                 125
Glu Arg Asp Leu Pro Phe Val Thr His Thr Leu Ser Ser Glu Phe Thr
    130                 135                 140
Ile Leu Arg Val Val Asn Gly Glu Thr Val Ala Ala Glu Asn Leu Gly
145                 150                 155                 160
Ile Thr Asn Gly Phe Val Lys Pro Lys Leu Val Gln Arg Pro Val Ile
                165                 170                 175
His Pro Leu Ser Ser Pro Ser Asn Arg Phe Cys Val Thr Ser Leu Asp
            180                 185                 190
Pro Asp Thr Leu Pro Ala Val Ala Thr Leu Leu Met Asp Val Met Phe
        195                 200                 205
Tyr Ser Asn Gly Val Lys Asp Pro Met Ala Thr Gly Asp Asp Cys Gly
    210                 215                 220
His Ile Arg Phe Phe Ser Phe Ser Leu Ile Glu Gly Tyr Ile Ser Leu
225                 230                 235                 240
Val Met Asp Val Gln Thr Gln Gln Arg Phe Pro Ser Asn Leu Leu Phe
                245                 250                 255
Thr Ser Ala Ser Gly Glu Leu Trp Lys Met Val Arg Ile Gly Gly Gln
            260                 265                 270
Pro Leu Gly Phe Asp Glu Cys Gly Ile Val Ala Gln Ile Ser Glu Pro
        275                 280                 285
Leu Ala Ala Ala Asp Ile Pro Ala Tyr Tyr Ile Ser Thr Phe Lys Phe
    290                 295                 300
Asp His Ala Leu Val Pro Glu Glu Asn Ile Asn Gly Val Ile Ser Ala
305                 310                 315                 320
Leu Lys Val Ser Gln Ala Glu Lys His
                325

<210> 45
<211> 900
<212> PRT
<213> Homo sapiens

<400> 45
Met Gly Asp Ser Gly Ser Arg Arg Ser Thr Leu Val Ser Arg Leu Pro
 1               5                  10                  15
Ile Phe Arg Arg Ser Ile Asn Arg Arg His Asp Ser Leu Pro Ser Ser
            20                  25                  30
Pro Ser Ser Ser Asn Thr Val Gly Val His Ser Ser Ser Pro Ser Ser
        35                  40                  45
Thr Asn Ser Ser Ser Gly Ser Thr Gly Lys Arg Arg Ser Ile Phe Arg
    50                  55                  60
Thr Pro Ser Ile Ser Phe His His Lys Lys Gly Ser Glu Pro Lys Gln
65                  70                  75                  80
Glu Pro Thr Asn Gln Asn Leu Ser Ile Ser Asn Gly Ala Gln Pro Gly
                85                  90                  95
His Ser Asn Met Gln Lys Leu Ser Leu Glu Glu His Ile Lys Thr Arg
            100                 105                 110
Gly Arg His Ser Val Gly Phe Ser Ser Ser Arg Asn Lys Lys Ile Thr
        115                 120                 125
Arg Ser Leu Thr Glu Asp Phe Glu Arg Glu Lys Glu His Ser Thr Asn
    130                 135                 140
Lys Asn Val Phe Ile Asn Cys Leu Ser Ser Gly Lys Ser Glu Gly Asp
145                 150                 155                 160
Asp Ser Gly Phe Thr Glu Asp Gln Thr Arg Arg Ser Val Lys Gln Ser
                165                 170                 175
Thr Arg Lys Leu Leu Pro Lys Ser Phe Ser Ser His Tyr Lys Phe Ser
            180                 185                 190
Lys Pro Val Leu Gln Ser Gln Ser Ile Ser Leu Val Gln Gln Ser Glu
        195                 200                 205
Phe Ser Leu Glu Val Thr Gln Tyr Gln Glu Arg Glu Pro Val Leu Val
    210                 215                 220
Arg Ala Ser Pro Ser Cys Ser Val Asp Val Thr Glu Arg Ala Gly Ser
225                 230                 235                 240
Ser Leu Gln Ser Pro Leu Leu Ser Ala Asp Leu Thr Thr Ala Gln Thr
                245                 250                 255
Pro Ser Glu Phe Leu Ala Leu Thr Glu Asp Ser Val Ser Glu Met Asp
            260                 265                 270
Ala Phe Ser Lys Ser Gly Ser Met Ala Ser His Cys Asp Asn Phe Gly
        275                 280                 285
His Asn Asp Ser Thr Ser Gln Met Ser Leu Asn Ser Ala Ala Val Thr
    290                 295                 300
Lys Thr Thr Thr Glu Leu Thr Gly Thr Val Pro Cys Ala Ile Met Ser
305                 310                 315                 320
Pro Gly Lys Tyr Arg Leu Glu Gly Gln Cys Ser Thr Glu Ser Asn Ser
                325                 330                 335
Leu Pro Glu Thr Ser Ala Ala Asn Gln Lys Glu Val Leu Leu Gln Ile
            340                 345                 350
Ala Glu Leu Pro Ala Thr Ser Val Ser His Ser Glu Ser Asn Leu Pro
        355                 360                 365
Ala Asp Ser Glu Arg Glu Glu Asn Ile Gly Leu Gln Asn Gly Glu Thr
    370                 375                 380
Met Leu Gly Thr Asn Ser Pro Arg Lys Leu Gly Phe Tyr Glu Gln His
385                 390                 395                 400
Lys Ala Ile Ala Glu His Val Lys Gly Ile His Pro Ile Ser Asp Ser
                405                 410                 415
Lys Ile Ile Pro Thr Ser Gly Asp His His Ile Phe Asn Lys Thr Ser
            420                 425                 430
His Gly Tyr Glu Ala Asn Pro Ala Lys Val Leu Ala Ser Ser Leu Ser
        435                 440                 445
Pro Phe Arg Glu Gly Arg Phe Ile Glu Arg Arg Leu Arg Ser Ser Ser
    450                 455                 460
Glu Gly Thr Ala Gly Ser Ser Arg Met Ile Leu Lys Pro Lys Asp Gly
465                 470                 475                 480
Asn Ile Glu Glu Val Asn Ser Leu Arg Lys Gln Arg Ala Gly Ser Ser
                485                 490                 495
Ser Ser Lys Met Asn Ser Leu Asp Val Leu Asn Asn Leu Gly Ser Cys
            500                 505                 510
Glu Leu Asp Glu Asp Asp Leu Met Leu Asp Leu Glu Phe Leu Glu Glu
        515                 520                 525
Gln Ser Leu His Pro Ser Val Cys Arg Glu Asp Ser Tyr His Ser Val
    530                 535                 540
Val Ser Cys Ala Ala Val Val Leu Thr Pro Met Glu Pro Met Ile Glu
545                 550                 555                 560
Met Lys Lys Arg Glu Glu Pro Glu Phe Pro Glu Pro Ser Lys Gln Asn
                565                 570                 575
Leu Ser Leu Lys Leu Thr Lys Asp Val Asp Gln Glu Ala Arg Cys Ser
            580                 585                 590
His Ile Ser Arg Met Pro Asn Ser Pro Ser Ala Asp Trp Pro Leu Gln
        595                 600                 605
Gly Val Glu Glu Asn Gly Gly Ile Asp Ser Leu Pro Phe Arg Leu Met
    610                 615                 620
Leu Gln Asp Cys Thr Ala Val Lys Thr Leu Leu Leu Lys Met Lys Arg
625                 630                 635                 640
Val Leu Gln Glu Ser Ala Asp Met Ser Pro Ala Ser Ser Thr Thr Ser
                645                 650                 655
Leu Pro Val Ser Pro Leu Thr Glu Glu Pro Val Pro Phe Lys Asp Ile
            660                 665                 670
Met Lys Asp Glu Cys Ser Met Leu Lys Leu Gln Leu Lys Glu Lys Asp
        675                 680                 685
Glu Leu Ile Ser Gln Leu Gln Glu Glu Leu Gly Lys Val Arg His Leu
    690                 695                 700
Gln Lys Ala Phe Ala Ser Arg Val Asp Lys Ser Thr Gln Thr Glu Leu
705                 710                 715                 720
Leu Cys Tyr Asp Gly Leu Asn Leu Lys Arg Leu Glu Thr Val Gln Gly
                725                 730                 735
Gly Arg Glu Ala Thr Tyr Arg Asn Arg Ile Val Ser Gln Asn Leu Ser
            740                 745                 750
Thr Arg Asp Arg Lys Ala Ile His Thr Pro Thr Glu Asp Arg Phe Arg
        755                 760                 765
Tyr Ser Ala Ala Asp Gln Thr Ser Pro Tyr Lys Asn Lys Thr Cys Gln
    770                 775                 780
Leu Pro Ser Leu Cys Leu Ser Asn Phe Leu Lys Asp Lys Glu Leu Ala
785                 790                 795                 800
Glu Val Ile Lys His Ser Arg Gly Thr Tyr Glu Thr Leu Thr Ser Asp
                805                 810                 815
Val Thr Gln Asn Leu Arg Ala Thr Val Gly Gln Ser Ser Leu Lys Pro
            820                 825                 830
Thr Ala Lys Thr Glu Gly Leu Ser Thr Phe Leu Glu Lys Pro Lys Asp
        835                 840                 845
Gln Val Ala Thr Ala Arg Gln His Ser Thr Phe Thr Gly Arg Phe Gly
    850                 855                 860
Gln Pro Pro Arg Gly Pro Ile Ser Leu His Met Tyr Ser Arg Lys Asn
865                 870                 875                 880
Val Phe Leu His His Asn Leu His Ser Thr Glu Leu Gln Thr Leu Gly
                885                 890                 895
Gln Gln Asp Gly
            900

<210> 46
<211> 898
<212> PRT
<213> Homo sapiens

<400> 46
Met Ala Ala Ala Ala Ala Glu Glu Gly Met Glu Pro Arg Ala Leu Gln
 1               5                  10                  15
Tyr Glu Gln Thr Leu Met Tyr Gly Arg Tyr Thr Gln Asp Leu Gly Ala
            20                  25                  30
Phe Ala Lys Glu Glu Ala Ala Arg Ile Arg Leu Gly Gly Pro Glu Pro
        35                  40                  45
Trp Lys Gly Pro Pro Ser Ser Arg Ala Ala Pro Glu Leu Leu Glu Tyr
    50                  55                  60
Gly Arg Ser Arg Cys Ala Arg Cys Arg Val Cys Ser Val Arg Cys His
65                  70                  75                  80
Lys Phe Leu Val Ser Arg Val Gly Glu Asp Trp Ile Phe Leu Val Leu
                85                  90                  95
Leu Gly Leu Leu Met Ala Leu Val Ser Trp Val Met Asp Tyr Ala Ile
            100                 105                 110
Ala Ala Cys Leu Gln Ala Gln Gln Trp Met Ser Arg Gly Leu Asn Thr
        115                 120                 125
Ser Ile Leu Leu Gln Tyr Leu Ala Trp Val Thr Tyr Pro Val Val Leu
    130                 135                 140
Ile Thr Phe Ser Ala Gly Phe Thr Gln Ile Leu Ala Pro Gln Ala Val
145                 150                 155                 160
Gly Ser Gly Ile Pro Glu Met Lys Thr Ile Leu Arg Gly Val Val Leu
                165                 170                 175
Lys Glu Tyr Leu Thr Leu Lys Thr Phe Ile Ala Lys Val Ile Gly Leu
            180                 185                 190
Thr Cys Ala Leu Gly Ser Gly Met Pro Leu Gly Lys Glu Gly Pro Phe
        195                 200                 205
Val His Ile Ala Ser Met Cys Ala Ala Leu Leu Ser Lys Phe Leu Ser
    210                 215                 220
Leu Phe Gly Gly Ile Tyr Glu Asn Glu Ser Arg Asn Thr Glu Met Leu
225                 230                 235                 240
Ala Ala Ala Cys Ala Val Gly Val Gly Cys Cys Phe Ala Ala Pro Ile
                245                 250                 255
Gly Gly Val Leu Phe Ser Ile Glu Val Thr Ser Thr Phe Phe Ala Val
            260                 265                 270
Arg Asn Tyr Trp Arg Gly Phe Phe Ala Ala Thr Phe Ser Ala Phe Ile
        275                 280                 285
Phe Arg Val Leu Ala Val Trp Asn Arg Asp Glu Glu Thr Ile Thr Ala
    290                 295                 300
Leu Phe Lys Thr Arg Phe Arg Leu Asp Phe Pro Phe Asp Leu Gln Glu
305                 310                 315                 320
Leu Pro Ala Phe Ala Val Ile Gly Ile Ala Ser Gly Phe Gly Gly Ala
                325                 330                 335
Leu Phe Val Tyr Leu Asn Arg Lys Ile Val Gln Val Met Arg Lys Gln
            340                 345                 350
Lys Thr Ile Asn Arg Phe Leu Met Arg Lys Arg Leu Leu Phe Pro Ala
        355                 360                 365
Leu Val Thr Leu Leu Ile Ser Thr Leu Thr Phe Pro Pro Gly Phe Gly
    370                 375                 380
Gln Phe Met Ala Gly Gln Leu Ser Gln Lys Glu Thr Leu Val Thr Leu
385                 390                 395                 400
Phe Asp Asn Arg Thr Trp Val Arg Gln Gly Leu Val Glu Glu Leu Glu
                405                 410                 415
Pro Pro Ser Thr Ser Gln Ala Trp Asn Pro Pro Arg Ala Asn Val Phe
            420                 425                 430
Leu Thr Leu Val Ile Phe Ile Leu Met Lys Phe Trp Met Ser Ala Leu
        435                 440                 445
Ala Thr Thr Ile Pro Val Pro Cys Gly Ala Phe Met Pro Val Phe Val
    450                 455                 460
Ile Gly Ala Ala Phe Gly Arg Leu Val Gly Glu Ser Met Ala Ala Trp
465                 470                 475                 480
Phe Pro Asp Gly Ile His Thr Asp Ser Ser Thr Tyr Arg Ile Val Pro
                485                 490                 495
Gly Gly Tyr Ala Val Val Gly Ala Ala Ala Leu Ala Gly Ala Val Thr
            500                 505                 510
His Thr Val Ser Thr Ala Val Ile Val Phe Glu Leu Thr Gly Gln Ile
        515                 520                 525
Ala His Ile Leu Pro Val Met Ile Ala Val Ile Leu Ala Asn Ala Val
    530                 535                 540
Ala Gln Ser Leu Gln Pro Ser Leu Tyr Asp Ser Ile Ile Arg Ile Lys
545                 550                 555                 560
Lys Leu Pro Tyr Leu Pro Glu Leu Gly Trp Gly Arg His Gln Gln Tyr
                565                 570                 575
Arg Val Arg Val Glu Asp Ile Met Val Arg Asp Val Pro His Val Ala
            580                 585                 590
Leu Ser Cys Thr Phe Arg Asp Leu Arg Leu Ala Leu His Arg Thr Lys
        595                 600                 605
Gly Arg Met Leu Ala Leu Val Glu Ser Pro Glu Ser Met Ile Leu Leu
    610                 615                 620
Gly Ser Ile Glu Arg Ser Gln Val Val Ala Leu Leu Gly Ala Gln Leu
625                 630                 635                 640
Ser Pro Ala Arg Arg Arg Gln His Met Gln Glu Arg Arg Ala Thr Gln
                645                 650                 655
Thr Ser Pro Leu Ser Asp Gln Glu Gly Pro Pro Thr Pro Glu Ala Ser
            660                 665                 670
Val Cys Phe Gln Val Asn Thr Glu Asp Ser Ala Phe Pro Ala Ala Arg
        675                 680                 685
Gly Glu Thr His Lys Pro Leu Lys Pro Ala Leu Lys Arg Gly Pro Ser
    690                 695                 700
Val Thr Arg Asn Leu Gly Glu Ser Pro Thr Gly Ser Ala Glu Ser Ala
705                 710                 715                 720
Gly Ile Ala Leu Arg Ser Leu Phe Cys Gly Ser Pro Pro Pro Glu Ala
                725                 730                 735
Ala Ser Glu Lys Leu Glu Ser Cys Glu Lys Arg Lys Leu Lys Arg Val
            740                 745                 750
Arg Ile Ser Leu Ala Ser Asp Ala Asp Leu Glu Gly Glu Met Ser Pro
        755                 760                 765
Glu Glu Ile Leu Glu Trp Glu Glu Gln Gln Leu Asp Glu Pro Val Asn
    770                 775                 780
Phe Ser Asp Cys Lys Ile Asp Pro Ala Pro Phe Gln Leu Val Glu Arg
785                 790                 795                 800
Thr Ser Leu His Lys Thr His Thr Ile Phe Ser Leu Leu Gly Val Asp
                805                 810                 815
His Ala Tyr Val Thr Ser Ile Gly Arg Leu Ile Gly Ile Val Thr Leu
            820                 825                 830
Lys Glu Leu Arg Lys Ala Ile Glu Gly Ser Val Thr Ala Gln Gly Val
        835                 840                 845
Lys Val Arg Pro Pro Leu Ala Ser Phe Arg Asp Ser Ala Thr Ser Ser
    850                 855                 860
Ser Asp Thr Glu Thr Thr Glu Val His Ala Leu Trp Gly Pro His Ser
865                 870                 875                 880
Arg His Gly Leu Pro Arg Glu Gly Ser Pro Ser Asp Ser Asp Asp Lys
                885                 890                 895
Cys Gln


<210> 47
<211> 575
<212> PRT
<213> Homo sapiens

<400> 47
Met Phe Gly Ile Gln Asp Thr Leu Gly Arg Gly Pro Thr Leu Lys Glu
 1               5                  10                  15
Lys Ser Leu Gly Ala Glu Met Asp Ser Val Arg Ser Trp Val Arg Asn
            20                  25                  30
Val Gly Val Val Asp Ala Asn Val Ala Ala Gln Ser Gly Val Ala Leu
        35                  40                  45
Ser Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys Ser
    50                  55                  60
Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln Pro
65                  70                  75                  80
Val Glu Ile Glu Arg Thr Ala Phe Val Asp Phe Val Glu Asn Asp Lys
                85                  90                  95
Glu Gln Gly Asn Glu Lys Thr Asn Asn Gly Thr His Tyr Lys Leu Gln
            100                 105                 110
Leu Leu Tyr Ser Asn Gly Val Arg Thr Glu Gln Asp Leu Tyr Val Arg
        115                 120                 125
Leu Ile Asp Ser Val Thr Lys Gln Pro Ile Ala Tyr Glu Gly Gln Asn
    130                 135                 140
Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Val Met Cys
145                 150                 155                 160
Ser Arg Cys Cys Glu Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr Pro
                165                 170                 175
Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu Lys
            180                 185                 190
Cys Asn Gln Asn Cys Leu Lys Thr Ala Gly Asn Pro Arg Asp Met Arg
        195                 200                 205
Arg Phe Gln Val Val Leu Ser Thr Thr Val Asn Val Asp Gly His Val
    210                 215                 220
Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His Gly
225                 230                 235                 240
Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Ala Thr Pro Cys Ile Lys
                245                 250                 255
Ala Ile Ser Pro Ser Glu Gly Trp Thr Thr Gly Gly Ala Met Val Ile
            260                 265                 270
Ile Ile Gly Asp Asn Phe Phe Asp Gly Leu Gln Val Val Phe Gly Thr
        275                 280                 285
Met Leu Val Trp Ser Glu Leu Ile Thr Pro His Ala Ile Arg Val Gln
    290                 295                 300
Thr Pro Pro Arg His Ile Pro Gly Val Val Glu Val Thr Leu Ser Tyr
305                 310                 315                 320
Lys Ser Lys Gln Phe Cys Lys Gly Ala Pro Gly Arg Phe Ile Tyr Thr
                325                 330                 335
Ala Leu Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln Arg Leu Gln Lys
            340                 345                 350
Val Ile Pro Arg His Pro Gly Asp Pro Glu Arg Leu Ala Lys Glu Met
        355                 360                 365
Leu Leu Lys Arg Ala Ala Asp Leu Val Glu Ala Leu Tyr Gly Thr Pro
    370                 375                 380
His Asn Asn Gln Asp Ile Ile Leu Lys Arg Ala Ala Asp Ile Ala Glu
385                 390                 395                 400
Ala Leu Tyr Ser Val Pro Arg Asn Pro Ser Gln Leu Pro Ala Leu Ser
                405                 410                 415
Ser Ser Pro Ala His Ser Gly Met Met Gly Ile Asn Ser Tyr Gly Ser
            420                 425                 430
Gln Leu Gly Val Ser Ile Ser Glu Ser Thr Gln Gly Asn Asn Gln Gly
        435                 440                 445
Tyr Ile Arg Asn Thr Ser Ser Ile Ser Pro Arg Gly Tyr Ser Ser Ser
    450                 455                 460
Ser Thr Pro Gln Gln Ser Asn Tyr Ser Thr Ser Ser Asn Ser Met Asn
465                 470                 475                 480
Gly Tyr Ser Asn Val Pro Met Ala Asn Leu Gly Val Pro Gly Ser Pro
                485                 490                 495
Gly Phe Leu Asn Gly Ser Pro Thr Gly Ser Pro Tyr Gly Ile Met Ser
            500                 505                 510
Ser Ser Pro Thr Val Gly Ser Ser Ser Thr Ser Ser Ile Leu Pro Phe
        515                 520                 525
Ser Ser Ser Val Phe Pro Ala Val Lys Gln Lys Ser Ala Phe Ala Pro
    530                 535                 540
Val Ile Arg Pro Gln Gly Ser Pro Ser Pro Ala Cys Ser Ser Gly Asn
545                 550                 555                 560
Gly Asn Gly Phe Arg Ala Met Thr Gly Leu Val Val Pro Pro Met
                565                 570                 575

<210> 48
<211> 434
<212> PRT
<213> Homo sapiens

<400> 48
Met Ser Arg Ser Arg His Leu Gly Lys Ile Arg Lys Arg Leu Glu Asp
 1               5                  10                  15
Val Lys Ser Gln Trp Val Arg Pro Ala Arg Ala Asp Phe Ser Asp Asn
            20                  25                  30
Glu Ser Ala Arg Leu Ala Thr Asp Ala Leu Leu Asp Gly Gly Ser Glu
        35                  40                  45
Ala Tyr Trp Arg Val Leu Ser Gln Glu Gly Glu Val Asp Phe Leu Ser
    50                  55                  60
Ser Val Glu Ala Gln Tyr Ile Gln Ala Gln Ala Arg Glu Pro Pro Cys
65                  70                  75                  80
Pro Pro Asp Thr Leu Gly Gly Ala Glu Ala Gly Pro Lys Gly Leu Asp
                85                  90                  95
Ser Ser Ser Leu Gln Ser Gly Thr Tyr Phe Pro Val Ala Ser Glu Gly
            100                 105                 110
Ser Glu Pro Ala Leu Leu His Ser Trp Ala Ser Ala Glu Lys Pro Tyr
        115                 120                 125
Leu Lys Glu Lys Ser Ser Ala Thr Val Tyr Phe Gln Thr Val Lys His
    130                 135                 140
Asn Asn Ile Arg Asp Leu Val Arg Arg Cys Ile Thr Arg Thr Ser Gln
145                 150                 155                 160
Val Leu Val Ile Leu Met Asp Val Phe Thr Asp Val Glu Ile Phe Cys
                165                 170                 175
Asp Ile Leu Glu Ala Ala Asn Lys Arg Gly Val Phe Val Cys Val Leu
            180                 185                 190
Leu Asp Gln Gly Gly Val Lys Leu Phe Gln Glu Met Cys Asp Lys Val
        195                 200                 205
Gln Ile Ser Asp Ser His Leu Lys Asn Ile Ser Ile Arg Ser Val Glu
    210                 215                 220
Gly Glu Ile Tyr Cys Ala Lys Ser Gly Arg Lys Phe Ala Gly Gln Ile
225                 230                 235                 240
Arg Glu Lys Phe Ile Ile Ser Asp Trp Arg Phe Val Leu Ser Gly Ser
                245                 250                 255
Tyr Ser Phe Thr Trp Leu Cys Gly His Val His Arg Asn Ile Leu Ser
            260                 265                 270
Lys Phe Thr Gly Gln Ala Val Glu Leu Phe Asp Glu Glu Phe Arg His
        275                 280                 285
Leu Tyr Ala Ser Ser Lys Pro Val Met Gly Leu Lys Ser Pro Arg Leu
    290                 295                 300
Val Ala Pro Val Pro Pro Gly Ala Ala Pro Ala Asn Gly Arg Leu Ser
305                 310                 315                 320
Ser Ser Ser Gly Ser Ala Ser Asp Arg Thr Ser Ser Asn Pro Phe Ser
                325                 330                 335
Gly Arg Ser Ala Gly Ser His Pro Gly Thr Arg Ser Val Ser Ala Ser
            340                 345                 350
Ser Gly Pro Cys Ser Pro Ala Ala Pro His Pro Pro Pro Pro Pro Arg
        355                 360                 365
Phe Gln Pro His Gln Gly Pro Trp Gly Ala Pro Ser Pro Gln Ala His
    370                 375                 380
Leu Ser Pro Arg Pro His Asp Gly Pro Pro Ala Ala Val Tyr Ser Asn
385                 390                 395                 400
Leu Gly Ala Tyr Arg Pro Thr Arg Leu Gln Leu Glu Gln Leu Gly Leu
                405                 410                 415
Val Pro Arg Leu Thr Pro Thr Trp Arg Pro Phe Leu Gln Ala Ser Pro
            420                 425                 430
His Phe


<210> 49
<211> 379
<212> PRT
<213> Homo sapiens

<400> 49
Met Ser Ser Ala Pro Glu Lys Gln Gln Pro Pro His Gly Gly Gly Gly
 1               5                  10                  15
Gly Gly Gly Gly Gly Gly Gly Ala Ala Met Asp Pro Ala Ser Ser Gly
            20                  25                  30
Pro Ser Lys Ala Lys Lys Thr Asn Ala Gly Ile Arg Arg Pro Glu Lys
        35                  40                  45
Pro Pro Tyr Ser Tyr Ile Ala Leu Ile Val Met Ala Ile Gln Ser Ser
    50                  55                  60
Pro Thr Lys Arg Leu Thr Leu Ser Glu Ile Tyr Gln Phe Leu Gln Ser
65                  70                  75                  80
Arg Phe Pro Phe Phe Arg Gly Ser Tyr Gln Gly Trp Lys Asn Ser Val
                85                  90                  95
Arg His Asn Leu Ser Leu Asn Glu Cys Phe Ile Lys Leu Pro Lys Gly
            100                 105                 110
Leu Gly Arg Pro Gly Lys Gly His Tyr Trp Thr Ile Asp Pro Ala Ser
        115                 120                 125
Glu Phe Met Phe Glu Glu Gly Ser Phe Arg Arg Arg Pro Arg Gly Phe
    130                 135                 140
Arg Arg Lys Cys Gln Ala Leu Lys Pro Met Tyr Ser Met Met Asn Gly
145                 150                 155                 160
Leu Gly Phe Asn His Leu Pro Asp Thr Tyr Gly Phe Gln Gly Ser Ala
                165                 170                 175
Gly Gly Leu Ser Cys Pro Pro Asn Ser Leu Ala Leu Glu Gly Gly Leu
            180                 185                 190
Gly Met Met Asn Gly His Leu Pro Gly Asn Val Asp Gly Met Ala Leu
        195                 200                 205
Pro Ser His Ser Val Pro His Leu Pro Ser Asn Gly Gly His Ser Tyr
    210                 215                 220
Met Gly Gly Cys Gly Gly Ala Ala Ala Gly Glu Tyr Pro His His Asp
225                 230                 235                 240
Ser Ser Val Pro Ala Ser Pro Leu Leu Pro Thr Gly Ala Gly Gly Val
                245                 250                 255
Met Glu Pro His Ala Val Tyr Ser Gly Ser Ala Ala Ala Trp Pro Pro
            260                 265                 270
Ser Ala Ser Ala Ala Leu Asn Ser Gly Ala Ser Tyr Ile Lys Gln Gln
        275                 280                 285
Pro Leu Ser Pro Cys Asn Pro Ala Ala Asn Pro Leu Ser Gly Ser Leu
    290                 295                 300
Ser Thr His Ser Leu Glu Gln Pro Tyr Leu His Gln Asn Ser His Asn
305                 310                 315                 320
Ala Pro Ala Glu Leu Gln Gly Ile Pro Arg Tyr His Ser Gln Ser Pro
                325                 330                 335
Ser Met Cys Asp Arg Lys Glu Phe Val Phe Ser Phe Asn Ala Met Ala
            340                 345                 350
Ser Ser Ser Met His Ser Ala Gly Gly Gly Ser Tyr Tyr His Gln Gln
        355                 360                 365
Val Thr Tyr Gln Asp Ile Lys Pro Cys Val Met
    370                 375

<210> 50
<211> 420
<212> PRT
<213> Homo sapiens

<400> 50
Met Ala Leu Tyr Cys Gly Asp Asn Phe Gly Val Tyr Ser Gln Pro Gly
 1               5                  10                  15
Leu Pro Pro Pro Ala Ala Thr Ala Ala Ala Pro Gly Ala Pro Pro Ala
            20                  25                  30
Ala Arg Ala Pro Tyr Gly Leu Ala Asp Tyr Ala Ala Pro Pro Ala Ala
        35                  40                  45
Ala Ala Asn Pro Tyr Leu Trp Leu Asn Gly Pro Gly Val Gly Gly Pro
    50                  55                  60
Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Tyr Leu Gly Ala Pro Pro
65                  70                  75                  80
Pro Pro Pro Pro Pro Gly Ala Ala Ala Gly Pro Phe Leu Gln Pro Pro
                85                  90                  95
Pro Ala Ala Gly Thr Phe Gly Cys Ser Gln Arg Pro Phe Ala Gln Pro
            100                 105                 110
Ala Pro Ala Ala Pro Ala Ser Pro Ala Ala Pro Ala Gly Pro Gly Glu
        115                 120                 125
Leu Gly Trp Leu Ser Met Ala Ser Arg Glu Asp Leu Met Lys Met Val
    130                 135                 140
Arg Pro Pro Tyr Ser Tyr Ser Ala Leu Ile Ala Met Ala Ile Gln Ser
145                 150                 155                 160
Ala Pro Glu Arg Lys Leu Thr Leu Ser His Ile Tyr Gln Phe Val Ala
                165                 170                 175
Asp Ser Phe Pro Phe Tyr Gln Arg Ser Lys Ala Gly Trp Gln Asn Ser
            180                 185                 190
Ile Arg His Asn Leu Ser Leu Asn Asp Cys Phe Lys Lys Val Pro Arg
        195                 200                 205
Asp Glu Asp Asp Pro Gly Lys Gly Asn Tyr Trp Thr Leu Asp Pro Asn
    210                 215                 220
Cys Glu Lys Met Phe Asp Asn Gly Asn Phe Arg Arg Lys Arg Lys Arg
225                 230                 235                 240
Arg Ser Glu Ala Ser Asn Gly Ser Thr Val Ala Ala Gly Thr Ser Lys
                245                 250                 255
Ser Glu Glu Gly Leu Ser Ser Gly Leu Gly Ser Gly Val Gly Gly Lys
            260                 265                 270
Pro Glu Glu Glu Ser Pro Ser Thr Leu Leu Arg Pro Ser His Ser Pro
        275                 280                 285
Glu Pro Pro Glu Gly Thr Lys Ser Thr Ala Ser Ser Pro Gly Gly Pro
    290                 295                 300
Met Leu Thr Ser Thr Pro Cys Leu Asn Thr Phe Phe Ser Ser Leu Ser
305                 310                 315                 320
Ser Leu Ser Val Ser Ser Ser Val Ser Thr Gln Arg Ala Leu Pro Gly
                325                 330                 335
Ser Arg His Leu Gly Ile Gln Gly Ala Gln Leu Pro Ser Ser Gly Val
            340                 345                 350
Phe Ser Pro Thr Ser Ile Ser Glu Ala Ser Ala Asp Thr Leu Gln Leu
        355                 360                 365
Ser Asn Ser Thr Ser Asn Ser Thr Gly Gln Arg Ser Ser Tyr Tyr Ser
    370                 375                 380
Pro Phe Pro Ala Ser Thr Ser Gly Gly Gln Ser Ser Pro Phe Ser Ser
385                 390                 395                 400
Pro Phe His Asn Phe Ser Met Val Asn Ser Leu Ile Tyr Pro Arg Glu
                405                 410                 415
Gly Ser Glu Val
            420

<210> 51
<211> 175
<212> PRT
<213> Homo sapiens

<400> 51
Met Thr Arg Thr Pro Val Gly Ser Ala Arg Thr Arg Pro Lys Pro Arg
 1               5                  10                  15
Lys Leu Gly Pro Gln Arg Gly Lys Ala Leu Gln Ala Ser Ser Arg Leu
            20                  25                  30
Ser Glu Ser Pro Ala Leu Val Lys Lys Arg Met Pro Asp Ala Cys Thr
        35                  40                  45
Leu Gly Arg Ala Gly Ile Gly Leu Pro Lys Met Cys Leu His Met Ala
    50                  55                  60
Val Arg His Ser Lys Ala Gln Lys Thr Gly Pro Gly Ile Leu Gln Gln
65                  70                  75                  80
Arg Gln Lys Pro Pro Ala Pro Arg Ala Ser Gly Gly Pro Ala Leu Leu
                85                  90                  95
Gly Lys Arg Arg Gly Cys Ser Glu Ala Gly Ser Ala Ser Leu Glu Pro
            100                 105                 110
Leu Ser Ser Ser Arg Ala Ala Ala Gly Cys Leu Asn Gln Val Pro Leu
        115                 120                 125
Ser Pro Phe Leu Ala Gly Pro Arg Asn Thr Arg Arg Leu Pro Ala Pro
    130                 135                 140
Glu Arg Glu Arg Ile Glu Leu Ala Ala Thr Leu Cys Leu Glu Gly Trp
145                 150                 155                 160
Pro Leu Arg Cys Leu Ala Ser Lys Gly Lys Leu His Cys Val Tyr
                165                 170                 175

<210> 52
<211> 299
<212> PRT
<213> Homo sapiens

<400> 52
Met Glu Glu Leu Leu Pro Asp Gly Gln Ile Trp Ala Asn Met Asp Pro
 1               5                  10                  15
Glu Glu Arg Met Leu Ala Ala Ala Thr Ala Phe Thr His Ile Cys Ala
            20                  25                  30
Gly Gln Gly Glu Gly Asp Val Arg Arg Glu Ala Gln Ser Ile Gln Tyr
        35                  40                  45
Asp Pro Tyr Ser Lys Ala Ser Val Ala Pro Gly Lys Arg Pro Ala Leu
    50                  55                  60
Pro Val Gln Leu Gln Tyr Pro His Val Glu Ser Asn Val Pro Ser Glu
65                  70                  75                  80
Thr Val Ser Glu Ala Ser Gln Arg Leu Arg Lys Pro Val Met Lys Arg
                85                  90                  95
Lys Val Leu Arg Arg Lys Pro Asp Gly Glu Val Leu Val Thr Asp Glu
            100                 105                 110
Ser Ile Ile Ser Glu Ser Glu Ser Gly Thr Glu Asn Asp Gln Asp Leu
        115                 120                 125
Trp Asp Leu Arg Gln Arg Leu Met Asn Val Gln Phe Gln Glu Asp Lys
    130                 135                 140
Glu Ser Ser Phe Asp Val Ser Gln Lys Phe Asn Leu Pro His Glu Tyr
145                 150                 155                 160
Gln Gly Ile Ser Gln Asp Gln Leu Ile Cys Ser Leu Gln Arg Glu Gly
                165                 170                 175
Met Gly Ser Pro Ala Tyr Glu Gln Asp Leu Ile Val Ala Ser Arg Pro
            180                 185                 190
Lys Ser Phe Ile Leu Pro Lys Leu Asp Gln Leu Ser Arg Asn Arg Gly
        195                 200                 205
Lys Thr Asp Arg Val Ala Arg Tyr Phe Glu Tyr Lys Arg Asp Trp Asp
    210                 215                 220
Ser Ile Arg Leu Pro Gly Glu Asp His Arg Lys Glu Leu Arg Trp Gly
225                 230                 235                 240
Val Arg Glu Gln Met Leu Cys Arg Ala Glu Pro Gln Ser Lys Pro Gln
                245                 250                 255
His Ile Tyr Val Pro Asn Asn Tyr Leu Val Pro Thr Glu Lys Lys Arg
            260                 265                 270
Ser Ala Leu Arg Trp Gly Val Arg Cys Asp Leu Ala Asn Gly Val Ile
        275                 280                 285
Pro Arg Lys Leu Pro Phe Pro Leu Ser Pro Ser
    290                 295

<210> 53
<211> 1786
<212> PRT
<213> Homo sapiens

<400> 53
Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Ala Leu Cys Arg
 1               5                  10                  15
Ala Arg Val Arg Ala Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu
            20                  25                  30
Gly Ser Cys Tyr Pro Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln
        35                  40                  45
Lys Leu Ser Val Thr Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr
    50                  55                  60
Cys Ile Val Ser His Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asn
65                  70                  75                  80
Ser Gln Asp Pro Tyr His Glu Thr Leu Asn Pro Asp Ser His Leu Ile
                85                  90                  95
Glu Asn Val Val Thr Thr Phe Ala Pro Asn Arg Leu Lys Ile Trp Trp
            100                 105                 110
Gln Ser Glu Asn Gly Val Glu Asn Val Thr Ile Gln Leu Asp Leu Glu
        115                 120                 125
Ala Glu Phe His Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg
    130                 135                 140
Pro Ala Ala Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp
145                 150                 155                 160
Gly Val Tyr Arg Tyr Phe Ala Tyr Asp Cys Glu Ala Ser Phe Pro Gly
                165                 170                 175
Ile Ser Thr Gly Pro Met Lys Lys Val Asp Asp Ile Ile Cys Asp Ser
            180                 185                 190
Arg Tyr Ser Asp Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Phe Arg
        195                 200                 205
Ala Leu Asp Pro Ala Phe Lys Ile Glu Asp Pro Tyr Ser Pro Arg Ile
    210                 215                 220
Gln Asn Leu Leu Lys Ile Thr Asn Leu Arg Ile Lys Phe Val Lys Leu
225                 230                 235                 240
His Thr Leu Gly Asp Asn Leu Leu Asp Ser Arg Met Glu Ile Arg Glu
                245                 250                 255
Lys Tyr Tyr Tyr Ala Val Tyr Asp Met Val Val Arg Gly Asn Cys Phe
            260                 265                 270
Cys Tyr Gly His Ala Ser Glu Cys Ala Pro Val Asp Gly Phe Asn Glu
        275                 280                 285
Glu Val Glu Gly Met Val His Gly His Cys Met Cys Arg His Asn Thr
    290                 295                 300
Lys Gly Leu Asn Cys Glu Leu Cys Met Asp Phe Tyr His Asp Leu Pro
305                 310                 315                 320
Trp Arg Pro Ala Glu Gly Arg Asn Ser Asn Ala Cys Lys Lys Cys Asn
                325                 330                 335
Cys Asn Glu His Ser Ile Ser Cys His Phe Asp Met Ala Val Tyr Leu
            340                 345                 350
Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn
        355                 360                 365
Thr Met Gly Arg Asn Cys Glu Gln Cys Lys Pro Phe Tyr Tyr Gln His
    370                 375                 380
Pro Glu Arg Asp Ile Arg Asp Pro Asn Phe Cys Glu Arg Cys Thr Cys
385                 390                 395                 400
Asp Pro Ala Gly Ser Gln Asn Glu Gly Ile Cys Asp Ser Tyr Thr Asp
                405                 410                 415
Phe Ser Thr Gly Leu Ile Ala Gly Gln Cys Arg Cys Lys Leu Asn Val
            420                 425                 430
Glu Gly Glu His Cys Asp Val Cys Lys Glu Gly Phe Tyr Asp Leu Ser
        435                 440                 445
Ser Glu Asp Pro Phe Gly Cys Lys Ser Cys Ala Cys Asn Pro Leu Gly
    450                 455                 460
Thr Ile Pro Gly Gly Asn Pro Cys Asp Ser Glu Thr Gly His Cys Tyr
465                 470                 475                 480
Cys Lys Arg Leu Val Thr Gly Gln His Cys Asp Gln Cys Leu Pro Glu
                485                 490                 495
His Trp Gly Leu Ser Asn Asp Leu Asp Gly Cys Arg Pro Cys Asp Cys
            500                 505                 510
Asp Leu Gly Gly Ala Leu Asn Asn Ser Cys Phe Ala Glu Ser Gly Gln
        515                 520                 525
Cys Ser Cys Arg Pro His Met Ile Gly Arg Gln Cys Asn Glu Val Glu
    530                 535                 540
Pro Gly Tyr Tyr Phe Ala Thr Leu Asp His Tyr Leu Tyr Glu Ala Glu
545                 550                 555                 560
Glu Ala Asn Leu Gly Pro Gly Val Ser Ile Val Glu Arg Gln Tyr Ile
                565                 570                 575
Gln Asp Arg Ile Pro Ser Trp Thr Gly Ala Gly Phe Val Arg Val Pro
            580                 585                 590
Glu Gly Ala Tyr Leu Glu Phe Phe Ile Asp Asn Ile Pro Tyr Ser Met
        595                 600                 605
Glu Tyr Asp Ile Leu Ile Arg Tyr Glu Pro Gln Leu Pro Asp His Trp
    610                 615                 620
Glu Lys Ala Val Ile Thr Val Gln Arg Pro Gly Arg Ile Pro Thr Ser
625                 630                 635                 640
Ser Arg Cys Gly Asn Thr Ile Pro Asp Asp Asp Asn Gln Val Val Ser
                645                 650                 655
Leu Ser Pro Gly Ser Arg Tyr Val Val Leu Pro Arg Pro Val Cys Phe
            660                 665                 670
Glu Lys Gly Thr Asn Tyr Thr Val Arg Leu Glu Leu Pro Gln Tyr Thr
        675                 680                 685
Ser Ser Asp Ser Asp Val Glu Ser Pro Tyr Thr Leu Ile Asp Ser Leu
    690                 695                 700
Val Leu Met Pro Tyr Cys Lys Ser Leu Asp Ile Phe Thr Val Gly Gly
705                 710                 715                 720
Ser Gly Asp Gly Val Val Thr Asn Ser Ala Trp Glu Thr Phe Gln Arg
                725                 730                 735
Tyr Arg Cys Leu Glu Asn Ser Arg Ser Val Val Lys Thr Pro Met Thr
            740                 745                 750
Asp Val Cys Arg Asn Ile Ile Phe Ser Ile Ser Ala Leu Leu His Gln
        755                 760                 765
Thr Gly Leu Ala Cys Glu Cys Asp Pro Gln Gly Ser Leu Ser Ser Val
    770                 775                 780
Cys Asp Pro Asn Gly Gly Gln Cys Gln Cys Arg Pro Asn Val Val Gly
785                 790                 795                 800
Arg Thr Cys Asn Arg Cys Ala Pro Gly Thr Phe Gly Phe Gly Pro Ser
                805                 810                 815
Gly Cys Lys Pro Cys Glu Cys His Leu Gln Gly Ser Val Asn Ala Phe
            820                 825                 830
Cys Asn Pro Val Thr Gly Gln Cys His Cys Phe Gln Gly Val Tyr Ala
        835                 840                 845
Arg Gln Cys Asp Arg Cys Leu Pro Gly His Trp Gly Phe Pro Ser Cys
    850                 855                 860
Gln Pro Cys Gln Cys Asn Gly His Ala Asp Asp Cys Asp Pro Val Thr
865                 870                 875                 880
Gly Glu Cys Leu Asn Cys Gln Asp Tyr Thr Met Gly His Asn Cys Glu
                885                 890                 895
Arg Cys Leu Ala Gly Tyr Tyr Gly Asp Pro Ile Ile Gly Ser Gly Asp
            900                 905                 910
His Cys Arg Pro Cys Pro Cys Pro Asp Gly Pro Asp Ser Gly Arg Gln
        915                 920                 925
Phe Ala Arg Ser Cys Tyr Gln Asp Pro Val Thr Leu Gln Leu Ala Cys
    930                 935                 940
Val Cys Asp Pro Gly Tyr Ile Gly Ser Arg Cys Asp Asp Cys Ala Ser
945                 950                 955                 960
Gly Tyr Phe Gly Asn Pro Ser Glu Val Gly Gly Ser Cys Gln Pro Cys
                965                 970                 975
Gln Cys His Asn Asn Ile Asp Thr Thr Asp Pro Glu Ala Cys Asp Lys
            980                 985                 990
Glu Thr Gly Arg Cys Leu Lys Cys Leu Tyr His Thr Glu Gly Glu His
        995                 1000                1005
Cys Gln Phe Cys Arg Phe Gly Tyr Tyr Gly Asp Ala Leu Gln Gln Asp
    1010                1015                1020
Cys Arg Lys Cys Val Cys Asn Tyr Leu Gly Thr Val Gln Glu His Cys
1025                1030                1035                1040
Asn Gly Ser Asp Cys Gln Cys Asp Lys Ala Thr Gly Gln Cys Leu Cys
                1045                1050                1055
Leu Pro Asn Val Ile Gly Gln Asn Cys Asp Arg Cys Ala Pro Asn Thr
            1060                1065                1070
Trp Gln Leu Ala Ser Gly Thr Gly Cys Asp Pro Cys Asn Cys Asn Ala
        1075                1080                1085
Ala His Ser Phe Gly Pro Ser Cys Asn Glu Phe Thr Gly Gln Cys Gln
    1090                1095                1100
Cys Met Pro Gly Phe Gly Gly Arg Thr Cys Ser Glu Cys Gln Glu Leu
1105                1110                1115                1120
Phe Trp Gly Asp Pro Asp Val Glu Cys Arg Ala Cys Asp Cys Asp Pro
                1125                1130                1135
Arg Gly Ile Glu Thr Pro Gln Cys Asp Gln Ser Thr Gly Gln Cys Val
            1140                1145                1150
Cys Val Glu Gly Val Glu Gly Pro Arg Cys Asp Lys Cys Thr Arg Gly
        1155                1160                1165
Tyr Ser Gly Val Phe Pro Asp Cys Thr Pro Cys His Gln Cys Phe Ala
    1170                1175                1180
Leu Trp Asp Val Ile Ile Ala Glu Leu Thr Asn Arg Thr His Arg Phe
1185                1190                1195                1200
Leu Glu Lys Ala Lys Ala Leu Lys Ile Ser Gly Val Ile Gly Pro Tyr
                1205                1210                1215
Arg Glu Thr Val Asp Ser Val Glu Arg Lys Val Ser Glu Ile Lys Asp
            1220                1225                1230
Ile Leu Ala Gln Ser Pro Ala Ala Glu Pro Leu Lys Asn Ile Gly Asn
        1235                1240                1245
Leu Phe Glu Glu Ala Glu Lys Leu Ile Lys Asp Val Thr Glu Met Met
    1250                1255                1260
Ala Gln Val Glu Val Lys Leu Ser Asp Thr Thr Ser Gln Ser Asn Ser
1265                1270                1275                1280
Thr Ala Lys Glu Leu Asp Ser Leu Gln Thr Glu Ala Glu Ser Leu Asp
                1285                1290                1295
Asn Thr Val Lys Glu Leu Ala Glu Gln Leu Glu Phe Ile Lys Asn Ser
            1300                1305                1310
Asp Ile Arg Gly Ala Leu Asp Ser Ile Thr Lys Tyr Phe Gln Met Ser
        1315                1320                1325
Leu Glu Ala Glu Glu Arg Val Asn Ala Ser Thr Thr Glu Pro Asn Ser
    1330                1335                1340
Thr Val Glu Gln Ser Ala Leu Met Arg Asp Arg Val Glu Asp Val Met
1345                1350                1355                1360
Met Glu Arg Glu Ser Gln Phe Lys Glu Lys Gln Glu Glu Gln Ala Arg
                1365                1370                1375
Leu Leu Asp Glu Leu Ala Gly Lys Leu Gln Ser Leu Asp Leu Ser Ala
            1380                1385                1390
Ala Ala Glu Met Thr Cys Gly Thr Pro Pro Gly Ala Ser Cys Ser Glu
        1395                1400                1405
Thr Glu Cys Gly Gly Pro Asn Cys Arg Thr Asp Glu Gly Glu Arg Lys
    1410                1415                1420
Cys Gly Gly Pro Gly Cys Gly Gly Leu Val Thr Val Ala His Asn Ala
1425                1430                1435                1440
Trp Gln Lys Ala Met Asp Leu Asp Gln Asp Val Leu Ser Ala Leu Ala
                1445                1450                1455
Glu Val Glu Gln Leu Ser Lys Met Val Ser Glu Ala Lys Leu Arg Ala
            1460                1465                1470
Asp Glu Ala Lys Gln Ser Ala Glu Asp Ile Leu Leu Lys Thr Asn Ala
        1475                1480                1485
Thr Lys Glu Lys Met Asp Lys Ser Asn Glu Glu Leu Arg Asn Leu Ile
    1490                1495                1500
Lys Gln Ile Arg Asn Phe Leu Thr Gln Asp Ser Ala Asp Leu Asp Ser
1505                1510                1515                1520
Ile Glu Ala Val Ala Asn Glu Val Leu Lys Met Glu Met Pro Ser Thr
                1525                1530                1535
Pro Gln Gln Leu Gln Asn Leu Thr Glu Asp Ile Arg Glu Arg Val Glu
            1540                1545                1550
Ser Leu Ser Gln Val Glu Val Ile Leu Gln His Ser Ala Ala Asp Ile
        1555                1560                1565
Ala Arg Ala Glu Met Leu Leu Glu Glu Ala Lys Arg Ala Ser Lys Ser
    1570                1575                1580
Ala Thr Asp Val Lys Val Thr Ala Asp Met Val Lys Glu Ala Leu Glu
1585                1590                1595                1600
Glu Ala Glu Lys Ala Gln Val Ala Ala Glu Lys Ala Ile Lys Gln Ala
                1605                1610                1615
Asp Glu Asp Ile Gln Gly Thr Gln Asn Leu Leu Thr Ser Ile Glu Ser
            1620                1625                1630
Glu Thr Ala Ala Ser Glu Glu Thr Leu Phe Asn Ala Ser Gln Arg Ile
        1635                1640                1645
Ser Glu Leu Glu Arg Asn Val Glu Glu Leu Lys Arg Lys Ala Ala Gln
    1650                1655                1660
Asn Ser Gly Glu Ala Glu Tyr Ile Glu Lys Val Val Tyr Thr Val Lys
1665                1670                1675                1680
Gln Ser Ala Glu Asp Val Lys Lys Thr Leu Asp Gly Glu Leu Asp Glu
                1685                1690                1695
Lys Tyr Lys Lys Val Glu Asn Leu Ile Ala Lys Lys Thr Glu Glu Ser
            1700                1705                1710
Ala Asp Ala Arg Arg Lys Ala Glu Met Leu Gln Asn Glu Ala Lys Thr
        1715                1720                1725
Leu Leu Ala Gln Ala Asn Ser Lys Leu Gln Leu Leu Lys Asp Leu Glu
    1730                1735                1740
Arg Lys Tyr Glu Asp Asn Gln Arg Tyr Leu Glu Asp Lys Ala Gln Glu
1745                1750                1755                1760
Leu Ala Arg Leu Glu Gly Glu Val Arg Ser Leu Leu Lys Asp Ile Ser
                1765                1770                1775
Gln Lys Val Ala Val Tyr Ser Thr Cys Leu
            1780                1785

<210> 54
<211> 61
<212> PRT
<213> Homo sapiens

<400> 54
Met Gln Pro Arg Thr Gln Pro Leu Ala Gln Thr Leu Pro Phe Phe Leu
 1               5                  10                  15
Gly Gly Ala Pro Arg Asp Thr Gly Leu Arg Val Pro Val Ile Lys Met
            20                  25                  30
Gly Thr Gly Trp Glu Gly Phe Gln Arg Thr Leu Lys Glu Val Ala Tyr
        35                  40                  45
Ile Leu Leu Cys Cys Trp Cys Ile Lys Glu Leu Leu Asp
    50                  55                  60

<210> 55
<211> 713
<212> PRT
<213> Homo sapiens

<400> 55
Met Ala Arg Ala Arg Gly Ser Pro Cys Pro Pro Leu Pro Pro Gly Arg
 1               5                  10                  15
Met Ser Trp Pro His Gly Ala Leu Leu Phe Leu Trp Leu Phe Ser Pro
            20                  25                  30
Pro Leu Gly Ala Gly Gly Gly Gly Val Ala Val Thr Ser Ala Ala Gly
        35                  40                  45
Gly Gly Ser Pro Pro Ala Thr Ser Cys Pro Val Ala Cys Ser Cys Ser
    50                  55                  60
Asn Gln Ala Ser Arg Val Ile Cys Thr Arg Arg Asp Leu Ala Glu Val
65                  70                  75                  80
Pro Ala Ser Ile Pro Val Asn Thr Arg Tyr Leu Asn Leu Gln Glu Asn
                85                  90                  95
Gly Ile Gln Val Ile Arg Thr Asp Thr Phe Lys His Leu Arg His Leu
            100                 105                 110
Glu Ile Leu Gln Leu Ser Lys Asn Leu Val Arg Lys Ile Glu Val Gly
        115                 120                 125
Ala Phe Asn Gly Leu Pro Ser Leu Asn Thr Leu Glu Leu Phe Asp Asn
    130                 135                 140
Arg Leu Thr Thr Val Pro Thr Gln Ala Phe Glu Tyr Leu Ser Lys Leu
145                 150                 155                 160
Arg Glu Leu Trp Leu Arg Asn Asn Pro Ile Glu Ser Ile Pro Ser Tyr
                165                 170                 175
Ala Phe Asn Arg Val Pro Ser Leu Arg Arg Leu Asp Leu Gly Glu Leu
            180                 185                 190
Lys Arg Leu Glu Tyr Ile Ser Glu Ala Ala Phe Glu Gly Leu Val Asn
        195                 200                 205
Leu Arg Tyr Leu Asn Leu Gly Met Cys Asn Leu Lys Asp Ile Pro Asn
    210                 215                 220
Leu Thr Ala Leu Val Arg Leu Glu Glu Leu Glu Leu Ser Gly Asn Arg
225                 230                 235                 240
Leu Asp Leu Ile Arg Pro Gly Ser Phe Gln Gly Leu Thr Ser Leu Arg
                245                 250                 255
Lys Leu Trp Leu Met His Ala Gln Val Ala Thr Ile Glu Arg Asn Ala
            260                 265                 270
Phe Asp Asp Leu Lys Ser Leu Glu Glu Leu Asn Leu Ser His Asn Asn
        275                 280                 285
Leu Met Ser Leu Pro His Asp Leu Phe Thr Pro Leu His Arg Leu Glu
    290                 295                 300
Arg Val His Leu Asn His Asn Pro Trp His Cys Asn Cys Asp Val Leu
305                 310                 315                 320
Trp Leu Ser Trp Trp Leu Lys Glu Thr Val Pro Ser Asn Thr Thr Cys
                325                 330                 335
Cys Ala Arg Cys His Ala Pro Ala Gly Leu Lys Gly Arg Tyr Ile Gly
            340                 345                 350
Glu Leu Asp Gln Ser His Phe Thr Cys Tyr Ala Pro Val Ile Val Glu
        355                 360                 365
Pro Pro Thr Asp Leu Asn Val Thr Glu Gly Met Ala Ala Glu Leu Lys
    370                 375                 380
Cys Arg Thr Gly Thr Ser Met Thr Ser Val Asn Trp Leu Thr Pro Asn
385                 390                 395                 400
Gly Thr Leu Met Thr His Gly Ser Tyr Arg Val Arg Ile Ser Val Leu
                405                 410                 415
His Asp Gly Thr Leu Asn Phe Thr Asn Val Thr Val Gln Asp Thr Gly
            420                 425                 430
Gln Tyr Thr Cys Met Val Thr Asn Ser Ala Gly Asn Thr Thr Ala Ser
        435                 440                 445
Ala Thr Leu Asn Val Ser Ala Val Asp Pro Val Ala Ala Gly Gly Thr
    450                 455                 460
Gly Ser Gly Gly Gly Gly Pro Gly Gly Ser Gly Gly Val Gly Gly Gly
465                 470                 475                 480
Ser Gly Gly Tyr Thr Tyr Phe Thr Thr Val Thr Val Glu Thr Leu Glu
                485                 490                 495
Thr Gln Pro Gly Glu Glu Ala Leu Gln Pro Arg Gly Thr Glu Lys Glu
            500                 505                 510
Pro Pro Gly Pro Thr Thr Asp Gly Val Trp Gly Gly Gly Arg Pro Gly
        515                 520                 525
Asp Ala Ala Gly Pro Ala Ser Ser Ser Thr Thr Ala Pro Ala Pro Arg
    530                 535                 540
Ser Ser Arg Pro Thr Glu Lys Ala Phe Thr Val Pro Ile Thr Asp Val
545                 550                 555                 560
Thr Glu Asn Ala Leu Lys Asp Leu Asp Asp Val Met Lys Thr Thr Lys
                565                 570                 575
Ile Ile Ile Gly Cys Phe Val Ala Ile Thr Phe Met Ala Ala Val Met
            580                 585                 590
Leu Val Ala Phe Tyr Lys Leu Arg Lys Gln His Gln Leu His Lys His
        595                 600                 605
His Gly Pro Thr Arg Thr Val Glu Ile Ile Asn Val Glu Asp Glu Leu
    610                 615                 620
Pro Ala Ala Ser Ala Val Ser Val Ala Ala Ala Ala Ala Val Ala Ser
625                 630                 635                 640
Gly Gly Gly Val Gly Gly Asp Ser His Leu Ala Leu Pro Ala Leu Glu
                645                 650                 655
Arg Asp His Leu Asn His His His Tyr Val Ala Ala Ala Phe Lys Ala
            660                 665                 670
His Tyr Ser Ser Asn Pro Ser Gly Gly Gly Cys Gly Gly Lys Gly Pro
        675                 680                 685
Pro Gly Leu Asn Ser Ile His Glu Pro Leu Leu Phe Lys Ser Gly Ser
    690                 695                 700
Lys Glu Asn Val Gln Glu Thr Gln Ile
705                 710

<210> 56
<211> 359
<212> PRT
<213> Homo sapiens

<400> 56
Met Ile Ala Ala Gln Ala Lys Leu Val Tyr Gln Leu Asn Lys Tyr Tyr
 1               5                  10                  15
Thr Glu Arg Cys Gln Ala Arg Lys Ala Ala Ile Ala Lys Thr Ile Arg
            20                  25                  30
Glu Val Cys Lys Val Val Ser Asp Val Leu Lys Glu Val Glu Val Gln
        35                  40                  45
Glu Pro Arg Phe Ile Ser Ser Leu Ser Glu Ile Asp Ala Arg Tyr Glu
    50                  55                  60
Gly Leu Glu Val Ile Ser Pro Thr Glu Phe Glu Val Val Leu Tyr Leu
65                  70                  75                  80
Asn Gln Met Gly Val Phe Asn Phe Val Asp Asp Gly Ser Leu Pro Gly
                85                  90                  95
Cys Ala Val Leu Lys Leu Ser Asp Gly Arg Lys Arg Ser Met Ser Leu
            100                 105                 110
Trp Val Glu Phe Ile Thr Ala Ser Gly Tyr Leu Ser Ala Arg Lys Ile
        115                 120                 125
Arg Ser Arg Phe Gln Thr Leu Val Ala Gln Ala Val Asp Lys Cys Ser
    130                 135                 140
Tyr Arg Asp Val Val Lys Met Ile Ala Asp Thr Ser Glu Val Lys Leu
145                 150                 155                 160
Arg Ile Arg Glu Arg Tyr Val Val Gln Ile Thr Pro Ala Phe Lys Cys
                165                 170                 175
Thr Gly Ile Trp Pro Arg Ser Ala Ala Gln Trp Pro Met Pro His Ile
            180                 185                 190
Pro Trp Pro Gly Pro Asn Arg Val Ala Glu Val Lys Ala Glu Gly Phe
        195                 200                 205
Asn Leu Leu Ser Lys Glu Cys Tyr Ser Leu Thr Gly Lys Gln Ser Ser
    210                 215                 220
Ala Glu Ser Asp Ala Trp Val Leu Gln Phe Gly Glu Ala Glu Asn Arg
225                 230                 235                 240
Leu Leu Met Gly Gly Cys Arg Asn Lys Cys Leu Ser Val Leu Lys Thr
                245                 250                 255
Leu Arg Asp Arg His Leu Glu Leu Pro Gly Gln Pro Leu Asn Asn Tyr
            260                 265                 270
His Met Lys Thr Leu Leu Leu Tyr Glu Cys Glu Lys His Pro Arg Glu
        275                 280                 285
Thr Asp Trp Asp Glu Ser Cys Leu Gly Asp Arg Leu Asn Gly Ile Leu
    290                 295                 300
Leu Gln Leu Ile Ser Cys Leu Gln Cys Arg Arg Cys Pro His Tyr Phe
305                 310                 315                 320
Leu Pro Asn Leu Asp Leu Phe Gln Gly Lys Pro His Ser Ala Leu Glu
                325                 330                 335
Ser Ala Ala Lys Gln Thr Trp Arg Leu Ala Arg Glu Ile Leu Thr Asn
            340                 345                 350
Pro Lys Ser Leu Asp Lys Leu
        355

<210> 57
<211> 497
<212> PRT
<213> Homo sapiens

<400> 57
Met Ala Ser Pro Ala Pro Pro Glu His Ala Glu Glu Gly Cys Pro Ala
 1               5                  10                  15
Pro Ala Ala Glu Glu Gln Ala Pro Pro Ser Pro Pro Pro Pro Gln Ala
            20                  25                  30
Ser Pro Ala Glu Arg Gln Gln Gln Glu Glu Glu Ala Gln Glu Ala Gly
        35                  40                  45
Ala Ala Glu Gly Ala Gly Leu Gln Val Glu Glu Ala Ala Gly Arg Ala
    50                  55                  60
Ala Ala Ala Val Thr Trp Leu Leu Gly Glu Pro Val Leu Trp Leu Gly
65                  70                  75                  80
Cys Arg Ala Asp Glu Leu Leu Ser Trp Lys Arg Pro Leu Arg Ser Leu
                85                  90                  95
Leu Gly Phe Val Ala Ala Asn Leu Leu Phe Trp Phe Leu Ala Leu Thr
            100                 105                 110
Pro Trp Arg Val Tyr His Leu Ile Ser Val Met Ile Leu Gly Arg Val
        115                 120                 125
Ile Met Gln Ile Ile Lys Asp Met Val Leu Ser Arg Thr Arg Gly Ala
    130                 135                 140
Gln Leu Trp Arg Ser Leu Ser Glu Ser Trp Glu Val Ile Asn Ser Lys
145                 150                 155                 160
Pro Asp Glu Arg Pro Arg Leu Ser His Cys Ile Ala Glu Ser Trp Met
                165                 170                 175
Asn Phe Ser Ile Phe Leu Gln Glu Met Ser Leu Phe Lys Gln Gln Ser
            180                 185                 190
Pro Gly Lys Phe Cys Leu Leu Val Cys Ser Val Cys Thr Phe Phe Thr
        195                 200                 205
Ile Leu Gly Ser Tyr Ile Pro Gly Val Ile Leu Ser Tyr Leu Leu Leu
    210                 215                 220
Leu Cys Ala Phe Leu Cys Pro Leu Phe Lys Cys Asn Asp Ile Gly Gln
225                 230                 235                 240
Lys Ile Tyr Ser Lys Ile Lys Ser Val Leu Leu Lys Leu Asp Phe Gly
                245                 250                 255
Ile Gly Glu Tyr Ile Asn Gln Lys Lys Arg Glu Arg Ser Glu Ala Asp
            260                 265                 270
Lys Glu Lys Ser His Lys Asp Asp Ser Glu Leu Asp Phe Ser Ala Leu
        275                 280                 285
Cys Pro Lys Ile Ser Leu Thr Val Ala Ala Lys Glu Leu Ser Val Ser
    290                 295                 300
Asp Thr Asp Val Ser Glu Val Ser Trp Thr Asp Asn Gly Thr Phe Asn
305                 310                 315                 320
Leu Ser Glu Gly Tyr Thr Pro Gln Thr Asp Thr Ser Asp Asp Leu Asp
                325                 330                 335
Arg Pro Ser Glu Glu Val Phe Ser Arg Asp Leu Ser Asp Phe Pro Ser
            340                 345                 350
Leu Glu Asn Gly Met Gly Thr Asn Asp Glu Asp Glu Leu Ser Leu Gly
        355                 360                 365
Leu Pro Thr Glu Leu Lys Arg Lys Lys Glu Gln Leu Asp Ser Gly His
    370                 375                 380
Arg Pro Ser Lys Glu Thr Gln Ser Ala Ala Gly Leu Thr Leu Pro Leu
385                 390                 395                 400
Asn Ser Asp Gln Thr Phe His Leu Met Ser Asn Leu Ala Gly Asp Val
                405                 410                 415
Ile Thr Ala Ala Val Thr Ala Ala Ile Lys Asp Gln Leu Glu Gly Val
            420                 425                 430
Gln Gln Ala Leu Ser Gln Ala Ala Pro Ile Pro Glu Glu Asp Thr Asp
        435                 440                 445
Thr Glu Glu Gly Asp Asp Phe Glu Leu Leu Asp Gln Ser Glu Leu Asp
    450                 455                 460
Gln Ile Glu Ser Glu Leu Gly Leu Thr Gln Asp Gln Glu Ala Glu Ala
465                 470                 475                 480
Gln Gln Asn Lys Lys Ser Ser Gly Phe Leu Ser Asn Leu Leu Gly Gly
                485                 490                 495
His


<210> 58
<211> 467
<212> PRT
<213> Homo sapiens

<400> 58
Met His Ser Thr Thr Pro Ile Ser Ser Leu Phe Ser Phe Thr Ser Pro
 1               5                  10                  15
Ala Val Lys Arg Leu Leu Gly Trp Lys Gln Gly Asp Glu Glu Glu Lys
            20                  25                  30
Trp Ala Glu Lys Ala Val Asp Ser Leu Val Lys Lys Leu Lys Lys Lys
        35                  40                  45
Lys Gly Ala Met Asp Glu Leu Glu Arg Ala Leu Ser Cys Pro Gly Gln
    50                  55                  60
Pro Ser Lys Cys Val Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln
65                  70                  75                  80
Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr Cys Arg Val Trp
                85                  90                  95
Arg Trp Pro Asp Leu Gln Ser His His Glu Leu Lys Pro Leu Glu Cys
            100                 105                 110
Cys Glu Phe Pro Phe Gly Ser Lys Gln Lys Glu Val Cys Ile Asn Pro
        115                 120                 125
Tyr His Tyr Arg Arg Val Glu Thr Pro Val Leu Pro Pro Val Leu Val
    130                 135                 140
Pro Arg His Ser Glu Tyr Asn Pro Gln Leu Ser Leu Leu Ala Lys Phe
145                 150                 155                 160
Arg Ser Ala Ser Leu His Ser Glu Pro Leu Met Pro His Asn Ala Thr
                165                 170                 175
Tyr Pro Asp Ser Phe Gln Gln Pro Pro Cys Ser Ala Leu Pro Pro Ser
            180                 185                 190
Pro Ser His Ala Phe Ser Gln Ser Pro Cys Thr Ala Ser Tyr Pro His
        195                 200                 205
Ser Pro Gly Ser Pro Ser Glu Pro Glu Ser Pro Tyr Gln His Ser Val
    210                 215                 220
Asp Thr Pro Pro Leu Pro Tyr His Ala Thr Glu Ala Ser Glu Thr Gln
225                 230                 235                 240
Ser Gly Gln Pro Val Asp Ala Thr Ala Asp Arg His Val Val Leu Ser
                245                 250                 255
Ile Pro Asn Gly Asp Phe Arg Pro Val Cys Tyr Glu Glu Pro Gln His
            260                 265                 270
Trp Cys Ser Val Ala Tyr Tyr Glu Leu Asn Asn Arg Val Gly Glu Thr
        275                 280                 285
Phe Gln Ala Ser Ser Arg Ser Val Leu Ile Asp Gly Phe Thr Asp Pro
    290                 295                 300
Ser Asn Asn Arg Asn Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn
305                 310                 315                 320
Arg Asn Ser Thr Ile Glu Asn Thr Arg Arg His Ile Gly Lys Gly Val
                325                 330                 335
His Leu Tyr Tyr Val Gly Gly Glu Val Tyr Ala Glu Cys Val Ser Asp
            340                 345                 350
Ser Ser Ile Phe Val Gln Ser Arg Asn Cys Asn Tyr Gln His Gly Phe
        355                 360                 365
His Pro Ala Thr Val Cys Lys Ile Pro Ser Gly Cys Ser Leu Lys Val
    370                 375                 380
Phe Asn Asn Gln Leu Phe Ala Gln Leu Leu Ala Gln Ser Val His His
385                 390                 395                 400
Gly Phe Glu Val Val Tyr Glu Leu Thr Lys Met Cys Thr Ile Arg Met
                405                 410                 415
Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr His Arg Gln Asp Val Thr
            420                 425                 430
Ser Thr Pro Cys Trp Ile Glu Ile His Leu His Gly Pro Leu Gln Trp
        435                 440                 445
Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro His Asn Pro Ile Ser
    450                 455                 460
Ser Val Ser
465

<210> 59
<211> 1347
<212> PRT
<213> Homo sapiens

<400> 59
Met Glu Asn Leu Pro Phe Pro Leu Lys Leu Leu Ser Ala Ser Ser Leu
 1               5                  10                  15
Asn Ala Pro Ser Ser Thr Pro Trp Val Leu Asp Ile Phe Leu Thr Leu
            20                  25                  30
Val Phe Ala Leu Gly Phe Phe Phe Leu Leu Leu Pro Tyr Leu Ser Tyr
        35                  40                  45
Phe Arg Cys Asp Asp Pro Pro Ser Pro Ser Pro Gly Lys Arg Lys Cys
    50                  55                  60
Pro Val Gly Arg Arg Arg Arg Pro Arg Gly Arg Met Lys Asn His Ser
65                  70                  75                  80
Leu Arg Ala Gly Arg Glu Cys Pro Arg Gly Leu Gln Glu Thr Ser Asp
                85                  90                  95
Leu Leu Ser Gln Leu Gln Ser Leu Leu Gly Pro His Leu Asp Lys Gly
            100                 105                 110
Asp Phe Gly Gln Leu Ser Gly Pro Asp Pro Pro Gly Glu Val Gly Glu
        115                 120                 125
Arg Ala Pro Asp Gly Ala Ser Gln Ser Ser His Glu Pro Met Glu Asp
    130                 135                 140
Ala Ala Pro Ile Leu Ser Pro Leu Ala Ser Pro Asp Pro Gln Ala Lys
145                 150                 155                 160
His Pro Gln Asp Leu Ala Ser Thr Pro Ser Pro Gly Pro Met Thr Thr
                165                 170                 175
Ser Val Ser Ser Leu Ser Ala Ser Gln Pro Pro Glu Pro Ser Leu Pro
            180                 185                 190
Leu Glu His Pro Ser Pro Glu Pro Pro Ala Leu Phe Pro His Pro Pro
        195                 200                 205
His Thr Pro Asp Pro Leu Ala Cys Ser Pro Pro Pro Pro Lys Gly Phe
    210                 215                 220
Thr Ala Pro Pro Leu Arg Asp Ser Thr Leu Ile Thr Pro Ser His Cys
225                 230                 235                 240
Asp Ser Val Ala Leu Pro Leu Gly Thr Val Pro Gln Ser Leu Ser Pro
                245                 250                 255
His Glu Asp Leu Val Ala Ser Val Pro Ala Ile Ser Gly Leu Gly Gly
            260                 265                 270
Ser Asn Ser His Val Ser Ala Ser Ser Arg Trp Gln Glu Thr Ala Arg
        275                 280                 285
Thr Ser Cys Ala Phe Asn Ser Ser Val Gln Gln Asp His Leu Ser Arg
    290                 295                 300
His Pro Pro Glu Thr Tyr Gln Met Glu Ala Gly Ser Leu Phe Leu Leu
305                 310                 315                 320
Ser Ser Asp Gly Gln Asn Ala Val Gly Ile Gln Val Thr Glu Thr Ala
                325                 330                 335
Lys Val Asn Ile Trp Glu Glu Lys Glu Asn Val Gly Ser Phe Thr Asp
            340                 345                 350
Arg Met Thr Pro Glu Lys His Leu Asn Ser Leu Arg Asn Leu Ala Lys
        355                 360                 365
Ser Leu Asp Ala Glu Gln Asp Thr Thr Asn Pro Lys Pro Phe Trp Asn
    370                 375                 380
Met Gly Glu Asn Ser Lys Gln Leu Pro Gly Pro Gln Lys Leu Ser Asp
385                 390                 395                 400
Pro Arg Leu Trp Gln Glu Ser Phe Trp Lys Asn Tyr Ser Gln Leu Phe
                405                 410                 415
Trp Gly Leu Pro Ser Leu His Ser Glu Ser Leu Val Ala Asn Ala Trp
            420                 425                 430
Val Thr Asp Arg Ser Tyr Thr Leu Gln Ser Pro Pro Phe Leu Phe Asn
        435                 440                 445
Glu Met Ser Asn Val Cys Pro Ile Gln Arg Glu Thr Thr Met Ser Pro
    450                 455                 460
Leu Leu Phe Gln Ala Gln Pro Pro Ser His Leu Gly Pro Glu Cys Gln
465                 470                 475                 480
Pro Phe Ile Ser Ser Thr Pro Gln Phe Arg Pro Thr Pro Met Ala Gln
                485                 490                 495
Ala Glu Ala Gln Ala His Leu Gln Ser Ser Phe Pro Val Leu Ser Pro
            500                 505                 510
Ala Phe Pro Ser Leu Ile Lys Asn Thr Gly Val Ala Cys Pro Ala Ser
        515                 520                 525
Gln Asn Lys Val Gln Ala Leu Ser Leu Pro Glu Thr Gln His Pro Glu
    530                 535                 540
Trp Pro Leu Leu Arg Arg Gln Leu Glu Gly Arg Leu Ala Leu Pro Ser
545                 550                 555                 560
Arg Val Gln Lys Ser Gln Asp Val Phe Ser Val Ser Thr Pro Asn Leu
                565                 570                 575
Pro Gln Glu Ser Leu Thr Ser Ile Leu Pro Glu Asn Phe Pro Val Ser
            580                 585                 590
Pro Glu Leu Arg Arg Gln Leu Glu Gln His Ile Lys Lys Trp Ile Ile
        595                 600                 605
Gln His Trp Gly Asn Leu Gly Arg Ile Gln Glu Ser Leu Asp Leu Met
    610                 615                 620
Gln Leu Arg Asp Glu Ser Pro Gly Thr Ser Gln Ala Lys Gly Lys Pro
625                 630                 635                 640
Ser Pro Trp Gln Ser Ser Met Ser Thr Gly Glu Ser Ser Lys Glu Ala
                645                 650                 655
Gln Lys Val Lys Phe Gln Leu Glu Arg Asp Pro Cys Pro His Leu Gly
            660                 665                 670
Gln Ile Leu Gly Glu Thr Pro Gln Asn Leu Ser Arg Asp Met Lys Ser
        675                 680                 685
Phe Pro Arg Lys Val Leu Gly Val Thr Ser Glu Glu Ser Glu Arg Asn
    690                 695                 700
Leu Arg Lys Pro Leu Arg Ser Asp Ser Gly Ser Asp Leu Leu Arg Cys
705                 710                 715                 720
Thr Glu Arg Thr His Ile Glu Asn Ile Leu Lys Ala His Met Gly Arg
                725                 730                 735
Asn Leu Gly Gln Thr Asn Glu Gly Leu Ile Pro Val Arg Val Arg Arg
            740                 745                 750
Ser Trp Leu Ala Val Asn Gln Ala Leu Pro Val Ser Asn Thr His Val
        755                 760                 765
Lys Thr Ser Asn Leu Ala Ala Pro Lys Ser Gly Lys Ala Cys Val Asn
    770                 775                 780
Thr Ala Gln Val Leu Ser Phe Leu Glu Pro Cys Thr Gln Gln Gly Leu
785                 790                 795                 800
Gly Ala His Ile Val Arg Phe Trp Ala Lys His Arg Trp Gly Leu Pro
                805                 810                 815
Leu Arg Val Leu Lys Pro Ile Gln Cys Phe Lys Leu Glu Lys Val Ser
            820                 825                 830
Ser Leu Ser Leu Thr Gln Leu Ala Gly Pro Ser Ser Ala Thr Cys Glu
        835                 840                 845
Ser Gly Ala Gly Ser Glu Val Glu Val Asp Met Phe Leu Arg Lys Pro
    850                 855                 860
Pro Met Ala Ser Leu Arg Lys Gln Val Leu Thr Lys Ala Ser Asp His
865                 870                 875                 880
Met Pro Glu Ser Leu Leu Ala Ser Ser Pro Ala Trp Lys Gln Phe Gln
                885                 890                 895
Arg Ala Pro Arg Gly Ile Pro Ser Trp Asn Asp His Gly Pro Leu Lys
            900                 905                 910
Pro Pro Pro Ala Gly Gln Glu Gly Arg Trp Pro Ser Lys Pro Leu Thr
        915                 920                 925
Tyr Ser Leu Thr Gly Ser Thr Gln Gln Ser Arg Ser Leu Gly Ala Gln
    930                 935                 940
Ser Ser Lys Ala Gly Glu Thr Arg Glu Ala Val Pro Gln Cys Arg Val
945                 950                 955                 960
Pro Leu Glu Thr Cys Met Leu Ala Asn Leu Gln Ala Thr Ser Glu Asp
                965                 970                 975
Met His Gly Phe Glu Ala Pro Gly Thr Ser Lys Ser Ser Leu His Pro
            980                 985                 990
Arg Val Ser Val Ser Gln Asp Pro Arg Lys Leu Cys Leu Met Glu Glu
        995                 1000                1005
Val Val Asn Glu Phe Glu Pro Gly Met Ala Thr Lys Ser Glu Thr Gln
    1010                1015                1020
Pro Gln Val Cys Ala Ala Val Val Leu Leu Pro Asp Gly Gln Ala Ser
1025                1030                1035                1040
Val Val Pro His Ala Ser Glu Asn Leu Val Ser Gln Val Pro Gln Gly
                1045                1050                1055
His Leu Gln Ser Met Pro Ala Gly Asn Met Arg Ala Ser Gln Glu Leu
            1060                1065                1070
His Asp Leu Met Ala Ala Arg Arg Ser Lys Leu Val His Glu Glu Pro
        1075                1080                1085
Arg Asn Pro Asn Cys Gln Gly Ser Cys Lys Asn Gln Arg Pro Met Phe
    1090                1095                1100
Pro Pro Ile His Lys Ser Glu Lys Ser Arg Lys Pro Asn Leu Glu Lys
1105                1110                1115                1120
His Glu Glu Arg Leu Glu Gly Leu Arg Thr Pro Gln Leu Thr Pro Val
                1125                1130                1135
Arg Lys Thr Glu Asp Thr His Gln Asp Glu Gly Val Gln Leu Leu Pro
            1140                1145                1150
Ser Lys Lys Gln Pro Pro Ser Val Ser His Phe Gly Gly Asn Ile Lys
        1155                1160                1165
Gln Phe Phe Gln Trp Ile Phe Ser Lys Lys Lys Ser Lys Pro Ala Pro
    1170                1175                1180
Val Thr Ala Glu Ser Gln Lys Thr Val Lys Asn Arg Ser Cys Val Tyr
1185                1190                1195                1200
Ser Ser Ser Ala Glu Ala Gln Gly Leu Met Thr Ala Val Gly Gln Met
                1205                1210                1215
Leu Asp Glu Lys Met Ser Leu Cys His Ala Arg His Ala Ser Lys Val
            1220                1225                1230
Asn Gln His Lys Gln Lys Phe Gln Ala Pro Val Cys Gly Phe Pro Cys
        1235                1240                1245
Asn His Arg His Leu Phe Tyr Ser Glu His Gly Arg Ile Leu Ser Tyr
    1250                1255                1260
Ala Ala Ser Ser Gln Gln Ala Thr Leu Lys Ser Gln Gly Cys Pro Asn
1265                1270                1275                1280
Arg Asp Arg Gln Ile Arg Asn Gln Gln Pro Leu Lys Ser Val Arg Cys
                1285                1290                1295
Asn Asn Glu Gln Trp Gly Leu Arg His Pro Gln Ile Leu His Pro Lys
            1300                1305                1310
Lys Ala Val Ser Pro Val Ser Pro Leu Gln His Trp Pro Lys Thr Ser
        1315                1320                1325
Gly Ala Ser Ser His His His His Cys Pro Arg His Cys Leu Leu Trp
    1330                1335                1340
Glu Gly Ile
1345

<210> 60
<211> 1031
<212> PRT
<213> Homo sapiens

<400> 60
Met Pro Pro Gly Arg Trp His Ala Ala Tyr Pro Ala Gln Ala Gln Ser
 1               5                  10                  15
Ser Arg Glu Arg Gly Arg Leu Gln Thr Val Lys Lys Glu Glu Glu Asp
            20                  25                  30
Glu Ser Tyr Thr Pro Val Gln Ala Ala Arg Pro Gln Thr Leu Asn Arg
        35                  40                  45
Pro Gly Gln Glu Leu Phe Arg Gln Leu Phe Arg Gln Leu Arg Tyr His
    50                  55                  60
Glu Ser Ser Gly Pro Leu Glu Thr Leu Ser Arg Leu Arg Glu Leu Cys
65                  70                  75                  80
Arg Trp Trp Leu Arg Pro Asp Val Leu Ser Lys Ala Gln Ile Leu Glu
                85                  90                  95
Leu Leu Val Leu Glu Gln Phe Leu Ser Ile Leu Pro Gly Glu Leu Arg
            100                 105                 110
Val Trp Val Gln Leu His Asn Pro Glu Ser Gly Glu Glu Ala Val Ala
        115                 120                 125
Leu Leu Glu Glu Leu Gln Arg Asp Leu Asp Gly Thr Ser Trp Arg Asp
    130                 135                 140
Pro Gly Pro Ala Gln Ser Pro Asp Val His Trp Met Gly Thr Gly Ala
145                 150                 155                 160
Leu Arg Ser Ala Gln Ile Trp Ser Leu Ala Ser Pro Leu Arg Ser Ser
                165                 170                 175
Ser Ala Leu Gly Asp His Leu Glu Pro Pro Tyr Glu Ile Glu Ala Arg
            180                 185                 190
Asp Phe Leu Ala Gly Gln Ser Asp Thr Pro Ala Ala Gln Met Pro Ala
        195                 200                 205
Leu Phe Pro Arg Glu Gly Cys Pro Gly Asp Gln Val Thr Pro Thr Arg
    210                 215                 220
Ser Leu Thr Ala Gln Leu Gln Glu Thr Met Thr Phe Lys Asp Val Glu
225                 230                 235                 240
Val Thr Phe Ser Gln Asp Glu Trp Gly Trp Leu Asp Ser Ala Gln Arg
                245                 250                 255
Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Met Ala Ser
            260                 265                 270
Leu Val Gly Pro Phe Thr Lys Pro Ala Leu Ile Ser Trp Leu Glu Ala
        275                 280                 285
Arg Glu Pro Trp Gly Leu Asn Met Gln Ala Ala Gln Pro Lys Gly Asn
    290                 295                 300
Pro Val Ala Ala Pro Thr Gly Asp Asp Leu Gln Ser Lys Thr Asn Lys
305                 310                 315                 320
Phe Ile Leu Asn Gln Glu Pro Leu Glu Glu Ala Glu Thr Leu Ala Val
                325                 330                 335
Ser Ser Gly Cys Pro Ala Thr Ser Val Ser Glu Gly Ile Gly Leu Arg
            340                 345                 350
Glu Ser Phe Gln Gln Lys Ser Arg Gln Lys Asp Gln Cys Glu Asn Pro
        355                 360                 365
Ile Gln Val Arg Val Lys Lys Glu Glu Thr Asn Phe Ser His Arg Thr
    370                 375                 380
Gly Lys Asp Ser Glu Val Ser Gly Ser Asn Ser Leu Asp Leu Lys His
385                 390                 395                 400
Val Thr Tyr Leu Arg Val Ser Gly Arg Lys Glu Ser Leu Lys His Gly
                405                 410                 415
Cys Gly Lys His Phe Arg Met Ser Ser His His Tyr Asp Tyr Lys Lys
            420                 425                 430
Tyr Gly Lys Gly Leu Arg His Met Ile Gly Gly Phe Ser Leu His Gln
        435                 440                 445
Arg Ile His Ser Gly Leu Lys Gly Asn Lys Lys Asp Val Cys Gly Lys
    450                 455                 460
Asp Phe Ser Leu Ser Ser His His Gln Arg Gly Gln Ser Leu His Thr
465                 470                 475                 480
Val Gly Val Ser Phe Lys Cys Ser Asp Cys Gly Arg Thr Phe Ser His
                485                 490                 495
Ser Ser His Leu Ala Tyr His Gln Arg Leu His Thr Gln Glu Lys Ala
            500                 505                 510
Phe Lys Cys Arg Val Cys Gly Lys Ala Phe Arg Trp Ser Ser Asn Cys
        515                 520                 525
Ala Arg His Glu Lys Ile His Thr Gly Val Lys Pro Tyr Lys Cys Asp
    530                 535                 540
Leu Cys Glu Lys Ala Phe Arg Arg Leu Ser Ala Tyr Arg Leu His Arg
545                 550                 555                 560
Glu Thr His Ala Lys Lys Lys Phe Leu Glu Leu Asn Gln Tyr Arg Ala
                565                 570                 575
Ala Leu Thr Tyr Ser Ser Gly Phe Asp His His Leu Gly Asp Gln Ser
            580                 585                 590
Gly Glu Lys Leu Phe Asp Cys Ser Gln Cys Arg Lys Ser Phe His Cys
        595                 600                 605
Lys Ser Tyr Val Leu Glu His Gln Arg Ile His Thr Gln Glu Lys Pro
    610                 615                 620
Tyr Lys Cys Thr Lys Cys Arg Lys Thr Phe Arg Trp Arg Ser Asn Phe
625                 630                 635                 640
Thr Arg His Met Arg Leu His Glu Glu Glu Lys Phe Tyr Lys Gln Asp
                645                 650                 655
Glu Cys Arg Glu Gly Phe Arg Gln Ser Pro Asp Cys Ser Gln Pro Gln
            660                 665                 670
Gly Ala Pro Ala Val Glu Lys Thr Phe Leu Cys Gln Gln Cys Gly Lys
        675                 680                 685
Thr Phe Thr Arg Lys Lys Thr Leu Val Asp His Gln Arg Ile His Thr
    690                 695                 700
Gly Glu Lys Pro Tyr Gln Cys Ser Asp Cys Gly Lys Asp Phe Ala Tyr
705                 710                 715                 720
Arg Ser Ala Phe Ile Val His Lys Lys Lys His Ala Met Lys Arg Lys
                725                 730                 735
Pro Glu Gly Gly Pro Ser Phe Ser Gln Asp Thr Val Phe Gln Val Pro
            740                 745                 750
Gln Ser Ser His Ser Lys Glu Glu Pro Tyr Lys Cys Ser Gln Cys Gly
        755                 760                 765
Lys Ala Phe Arg Asn His Ser Phe Leu Leu Ile His Gln Arg Val His
    770                 775                 780
Thr Gly Glu Lys Pro Tyr Lys Cys Arg Glu Cys Gly Lys Ala Phe Arg
785                 790                 795                 800
Trp Ser Ser Asn Leu Tyr Arg His Gln Arg Ile His Ser Leu Gln Lys
                805                 810                 815
Gln Tyr Asp Cys His Glu Ser Glu Lys Thr Pro Asn Val Glu Pro Lys
            820                 825                 830
Ile Leu Thr Gly Glu Lys Arg Phe Trp Cys Gln Glu Cys Gly Lys Thr
        835                 840                 845
Phe Thr Arg Lys Arg Thr Leu Leu Asp His Lys Gly Ile His Ser Gly
    850                 855                 860
Glu Lys Arg Tyr Lys Cys Asn Leu Cys Gly Lys Ser Tyr Asp Arg Asn
865                 870                 875                 880
Tyr Arg Leu Val Asn His Gln Arg Ile His Ser Thr Glu Arg Pro Phe
                885                 890                 895
Lys Cys Gln Trp Cys Gly Lys Glu Phe Ile Gly Arg His Thr Leu Ser
            900                 905                 910
Ser His Gln Arg Lys His Thr Arg Ala Ala Gln Ala Glu Arg Ser Pro
        915                 920                 925
Pro Ala Arg Ser Ser Ser Gln Asp Thr Lys Leu Arg Leu Gln Lys Leu
    930                 935                 940
Lys Pro Ser Glu Glu Met Pro Leu Glu Asp Cys Lys Glu Ala Cys Ser
945                 950                 955                 960
Gln Ser Ser Arg Leu Thr Gly Leu Gln Asp Ile Ser Ile Gly Lys Lys
                965                 970                 975
Cys His Lys Cys Ser Ile Cys Gly Lys Thr Phe Asn Lys Ser Ser Gln
            980                 985                 990
Leu Ile Ser His Lys Arg Phe His Thr Arg Glu Arg Pro Phe Lys Cys
        995                 1000                1005
Ser Lys Cys Gly Lys Thr Phe Arg Trp Ser Ser Asn Leu Ala Arg His
    1010                1015                1020
Met Lys Asn His Ile Arg Asp
1025                1030

<210> 61
<211> 1075
<212> PRT
<213> Homo sapiens

<400> 61
Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu
 1               5                  10                  15
Leu Cys Gly Ser Ile Thr Leu Ala Leu Gly Asn Ala Gln Lys Leu Pro
            20                  25                  30
Lys Gly Lys Arg Pro Asn Leu Lys Val His Ile Asn Thr Thr Ser Asp
        35                  40                  45
Ser Ile Leu Leu Lys Phe Leu Arg Pro Ser Pro Asn Val Lys Leu Glu
    50                  55                  60
Gly Leu Leu Leu Gly Tyr Gly Ser Asn Val Ser Pro Asn Gln Tyr Phe
65                  70                  75                  80
Pro Leu Pro Ala Glu Gly Lys Phe Thr Glu Ala Ile Val Asp Ala Glu
                85                  90                  95
Pro Lys Tyr Leu Ile Val Val Arg Pro Ala Pro Pro Pro Ser Gln Lys
            100                 105                 110
Lys Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro Leu Gln Leu Val
        115                 120                 125
Val Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser Trp Gly Phe Leu
    130                 135                 140
Ile Asn Pro His His Asp Trp Thr Leu Pro Ser His Cys Pro Asn Asp
145                 150                 155                 160
Arg Phe Tyr Thr Ile Arg Tyr Arg Glu Lys Asp Lys Glu Lys Lys Trp
                165                 170                 175
Ile Phe Gln Ile Cys Pro Ala Thr Glu Thr Ile Val Glu Asn Leu Lys
            180                 185                 190
Pro Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn Val Glu Gly Gly
        195                 200                 205
Ile Trp Ser Lys Ile Phe Asn His Lys Thr Val Val Gly Ser Lys Lys
    210                 215                 220
Val Asn Gly Lys Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro
225                 230                 235                 240
Ala Tyr Val Pro Arg Lys Leu Ile Pro Ile Thr Ile Ile Lys Gln Val
                245                 250                 255
Ile Gln Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala
            260                 265                 270
Pro Leu Gly Gly Val Ile Leu Val His Leu Ile Ile Pro Gly Leu Asn
        275                 280                 285
Glu Thr Thr Val Lys Leu Pro Ala Ser Leu Met Phe Glu Ile Ser Asp
    290                 295                 300
Ala Leu Lys Thr Gln Leu Ala Lys Asn Glu Thr Leu Ala Leu Pro Ala
305                 310                 315                 320
Glu Ser Lys Thr Pro Glu Val Glu Lys Ile Ser Ala Arg Pro Thr Thr
                325                 330                 335
Val Thr Pro Glu Thr Val Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser
            340                 345                 350
Ala Leu Asp Val Ser Glu Thr Thr Leu Ala Ser Ser Glu Lys Pro Trp
        355                 360                 365
Ile Val Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu Gln Pro
    370                 375                 380
Gln Thr Ala Thr Tyr Asp Val Phe Ser Ser Pro Thr Thr Ser Asp Glu
385                 390                 395                 400
Pro Glu Ile Ser Asp Ser Tyr Thr Ala Thr Ser Asp Arg Ile Leu Asp
                405                 410                 415
Ser Ile Pro Pro Lys Thr Ser Arg Thr Leu Glu Gln Pro Arg Ala Thr
            420                 425                 430
Leu Ala Pro Ser Glu Thr Pro Phe Val Pro Gln Lys Leu Glu Ile Phe
        435                 440                 445
Thr Ser Pro Glu Met Gln Pro Thr Thr Pro Ala Pro Gln Gln Thr Thr
    450                 455                 460
Ser Ile Pro Ser Thr Pro Lys Arg Arg Pro Arg Pro Lys Pro Pro Arg
465                 470                 475                 480
Thr Lys Pro Glu Arg Thr Thr Ser Ala Gly Thr Ile Thr Pro Lys Ile
                485                 490                 495
Ser Lys Ser Pro Glu Pro Thr Trp Thr Thr Pro Ala Pro Gly Lys Thr
            500                 505                 510
Gln Phe Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val Thr
        515                 520                 525
His Thr Lys Pro Ala Pro Lys Gln Thr Pro Arg Ala Pro Pro Lys Pro
    530                 535                 540
Lys Thr Ser Pro Arg Pro Arg Ile Pro Gln Thr Gln Pro Val Pro Lys
545                 550                 555                 560
Val Pro Gln Arg Val Thr Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu
                565                 570                 575
Val Ser Tyr Thr Thr Pro Ala Pro Lys Asp Val Leu Leu Pro His Lys
            580                 585                 590
Pro Tyr Pro Glu Val Ser Gln Ser Glu Pro Ala Pro Leu Glu Thr Arg
        595                 600                 605
Gly Ile Pro Phe Ile Pro Met Ile Ser Pro Ser Pro Ser Gln Glu Glu
    610                 615                 620
Leu Gln Thr Thr Leu Glu Glu Thr Asp Gln Ser Thr Gln Glu Pro Phe
625                 630                 635                 640
Thr Thr Lys Ile Pro Arg Thr Thr Glu Leu Ala Lys Thr Thr Gln Ala
                645                 650                 655
Pro His Arg Phe Tyr Thr Thr Val Arg Pro Arg Thr Ser Asp Lys Pro
            660                 665                 670
His Ile Arg Pro Gly Val Lys Gln Ala Pro Arg Pro Ser Gly Ala Asp
        675                 680                 685
Arg Asn Val Ser Val Asp Ser Thr His Pro Thr Lys Lys Pro Gly Thr
    690                 695                 700
Arg Arg Pro Pro Leu Pro Pro Arg Pro Thr His Pro Arg Arg Lys Pro
705                 710                 715                 720
Leu Pro Pro Asn Asn Val Thr Gly Lys Pro Gly Ser Ala Gly Ile Ile
                725                 730                 735
Ser Ser Gly Pro Ile Thr Thr Pro Pro Leu Arg Ser Thr Pro Arg Pro
            740                 745                 750
Thr Gly Thr Pro Leu Glu Arg Ile Glu Thr Asp Ile Lys Gln Pro Thr
        755                 760                 765
Val Pro Ala Ser Gly Glu Glu Leu Glu Asn Ile Thr Asp Phe Ser Ser
    770                 775                 780
Ser Pro Thr Arg Glu Thr Asp Pro Leu Gly Lys Pro Arg Phe Lys Gly
785                 790                 795                 800
Pro His Val Arg Tyr Ile Gln Lys Pro Asp Asn Ser Pro Cys Ser Ile
                805                 810                 815
Thr Asp Ser Val Lys Arg Phe Pro Lys Glu Glu Ala Thr Glu Gly Asn
            820                 825                 830
Ala Thr Ser Pro Pro Gln Asn Pro Pro Thr Asn Leu Thr Val Val Thr
        835                 840                 845
Val Glu Gly Cys Pro Ser Phe Val Ile Leu Asp Trp Glu Lys Pro Leu
    850                 855                 860
Asn Asp Thr Val Thr Glu Tyr Glu Val Ile Ser Arg Glu Asn Gly Ser
865                 870                 875                 880
Phe Ser Gly Lys Asn Lys Ser Ile Gln Met Thr Asn Gln Thr Phe Ser
                885                 890                 895
Thr Val Glu Asn Leu Lys Pro Asn Thr Ser Tyr Glu Phe Gln Val Lys
            900                 905                 910
Pro Lys Asn Pro Leu Gly Glu Gly Pro Val Ser Asn Thr Val Ala Phe
        915                 920                 925
Ser Thr Glu Ser Ala Asp Pro Arg Val Ser Glu Pro Val Ser Ala Gly
    930                 935                 940
Arg Asp Ala Ile Trp Thr Glu Arg Pro Phe Asn Ser Asp Ser Tyr Ser
945                 950                 955                 960
Glu Cys Lys Gly Lys Gln Tyr Val Lys Arg Thr Trp Tyr Lys Lys Phe
                965                 970                 975
Val Gly Val Gln Leu Cys Asn Ser Leu Arg Tyr Lys Ile Tyr Leu Ser
            980                 985                 990
Asp Ser Leu Thr Gly Lys Phe Tyr Asn Ile Gly Asp Gln Arg Gly His
        995                 1000                1005
Gly Glu Asp His Cys Gln Phe Val Asp Ser Phe Leu Asp Gly Arg Thr
    1010                1015                1020
Gly Gln Gln Leu Thr Ser Asp Gln Leu Pro Ile Lys Glu Gly Tyr Phe
1025                1030                1035                1040
Arg Ala Val Arg Gln Glu Pro Val Gln Phe Gly Glu Ile Gly Gly His
                1045                1050                1055
Thr Gln Ile Asn Tyr Val Gln Trp Tyr Glu Cys Gly Thr Thr Ile Pro
            1060                1065                1070
Gly Lys Trp
        1075

<210> 62
<211> 272
<212> PRT
<213> Homo sapiens

<400> 62
Met Gly Asn Thr Thr Ser Asp Arg Val Ser Gly Glu Arg His Gly Ala
 1               5                  10                  15
Lys Ala Ala Arg Ser Glu Gly Ala Gly Gly His Ala Pro Gly Lys Glu
            20                  25                  30
His Lys Ile Met Val Gly Ser Thr Asp Asp Pro Ser Val Phe Ser Leu
        35                  40                  45
Pro Asp Ser Lys Leu Pro Gly Asp Lys Glu Phe Val Ser Trp Gln Gln
    50                  55                  60
Asp Leu Glu Asp Ser Val Lys Pro Thr Gln Gln Ala Arg Pro Thr Val
65                  70                  75                  80
Ile Arg Trp Ser Glu Gly Gly Lys Glu Val Phe Ile Ser Gly Ser Phe
                85                  90                  95
Asn Asn Trp Ser Thr Lys Ile Pro Leu Ile Lys Ser His Asn Asp Phe
            100                 105                 110
Val Ala Ile Leu Asp Leu Pro Glu Gly Glu His Gln Tyr Lys Phe Phe
        115                 120                 125
Val Asp Gly Gln Trp Val His Asp Pro Ser Glu Pro Val Val Thr Ser
    130                 135                 140
Gln Leu Gly Thr Ile Asn Asn Leu Ile His Val Lys Lys Ser Asp Phe
145                 150                 155                 160
Glu Val Phe Asp Ala Leu Lys Leu Asp Ser Met Glu Ser Ser Glu Thr
                165                 170                 175
Ser Cys Arg Asp Leu Ser Ser Ser Pro Pro Gly Pro Tyr Gly Gln Glu
            180                 185                 190
Met Tyr Ala Phe Arg Ser Glu Glu Arg Phe Lys Ser Pro Pro Ile Leu
        195                 200                 205
Pro Pro His Leu Leu Gln Val Ile Leu Asn Lys Asp Thr Asn Ile Ser
    210                 215                 220
Cys Asp Pro Ala Leu Leu Pro Glu Pro Asn His Val Met Leu Asn His
225                 230                 235                 240
Leu Tyr Ala Leu Ser Ile Lys Asp Ser Val Met Val Leu Ser Ala Thr
                245                 250                 255
His Arg Tyr Lys Lys Lys Tyr Val Thr Thr Leu Leu Tyr Lys Pro Ile
            260                 265                 270

<210> 63
<211> 295
<212> PRT
<213> Homo sapiens

<400> 63
Met Glu Leu Ile Gln Asp Thr Ser Arg Pro Pro Leu Glu Tyr Val Lys
 1               5                  10                  15
Gly Val Pro Leu Ile Lys Tyr Phe Ala Glu Ala Leu Gly Pro Leu Gln
            20                  25                  30
Ser Phe Gln Ala Arg Pro Asp Asp Leu Leu Ile Asn Thr Tyr Pro Lys
        35                  40                  45
Ser Gly Thr Thr Trp Val Ser Gln Ile Leu Asp Met Ile Tyr Gln Gly
    50                  55                  60
Gly Asp Leu Glu Lys Cys Asn Arg Ala Pro Ile Tyr Val Arg Val Pro
65                  70                  75                  80
Phe Leu Glu Val Asn Asp Pro Gly Glu Pro Ser Gly Leu Glu Thr Leu
                85                  90                  95
Lys Asp Thr Pro Pro Pro Arg Leu Ile Lys Ser His Leu Pro Leu Ala
            100                 105                 110
Leu Leu Pro Gln Thr Leu Leu Asp Gln Lys Val Lys Val Val Tyr Val
        115                 120                 125
Ala Arg Asn Pro Lys Asp Val Ala Val Ser Tyr Tyr His Phe His Arg
    130                 135                 140
Met Glu Lys Ala His Pro Glu Pro Gly Thr Trp Asp Ser Phe Leu Glu
145                 150                 155                 160
Lys Phe Met Ala Gly Glu Val Ser Tyr Gly Ser Trp Tyr Gln His Val
                165                 170                 175
Gln Glu Trp Trp Glu Leu Ser Arg Thr His Pro Val Leu Tyr Leu Phe
            180                 185                 190
Tyr Glu Asp Met Lys Glu Asn Pro Lys Arg Glu Ile Gln Lys Ile Leu
        195                 200                 205
Glu Phe Val Gly Arg Ser Leu Pro Glu Glu Thr Met Asp Phe Met Val
    210                 215                 220
Gln His Thr Ser Phe Lys Glu Met Lys Lys Asn Pro Met Thr Asn Tyr
225                 230                 235                 240
Thr Thr Val Pro Gln Glu Leu Met Asp His Ser Ile Ser Pro Phe Met
                245                 250                 255
Arg Lys Gly Met Ala Gly Asp Trp Lys Thr Thr Phe Thr Val Ala Gln
            260                 265                 270
Asn Glu Arg Phe Asp Ala Asp Tyr Ala Glu Lys Met Ala Gly Cys Ser
        275                 280                 285
Leu Ser Phe Arg Ser Glu Leu
    290                 295

<210> 64
<211> 491
<212> PRT
<213> Homo sapiens

<400> 64
Met Ala Gly Gln Gly Leu Pro Leu His Val Ala Thr Leu Leu Thr Gly
 1               5                  10                  15
Leu Leu Glu Cys Leu Gly Phe Ala Gly Val Leu Phe Gly Trp Pro Ser
            20                  25                  30
Leu Val Phe Val Phe Lys Asn Glu Asp Tyr Phe Lys Asp Leu Cys Gly
        35                  40                  45
Pro Asp Ala Gly Pro Ile Gly Asn Ala Thr Gly Gln Ala Asp Cys Lys
    50                  55                  60
Ala Gln Asp Glu Arg Phe Ser Leu Ile Phe Thr Leu Gly Ser Phe Met
65                  70                  75                  80
Asn Asn Phe Met Thr Phe Pro Thr Gly Tyr Ile Phe Asp Arg Phe Lys
                85                  90                  95
Thr Thr Val Ala Arg Leu Ile Ala Ile Phe Phe Tyr Thr Thr Ala Thr
            100                 105                 110
Leu Ile Ile Ala Phe Thr Ser Ala Gly Ser Ala Val Leu Leu Phe Leu
        115                 120                 125
Ala Met Pro Met Leu Thr Ile Gly Gly Ile Leu Phe Leu Ile Thr Asn
    130                 135                 140
Leu Gln Ile Gly Asn Leu Phe Gly Gln His Arg Ser Thr Ile Ile Thr
145                 150                 155                 160
Leu Tyr Asn Gly Ala Phe Asp Ser Ser Ser Ala Val Phe Leu Ile Ile
                165                 170                 175
Lys Leu Leu Tyr Glu Lys Gly Ile Ser Leu Arg Ala Ser Phe Ile Phe
            180                 185                 190
Ile Ser Val Cys Ser Thr Trp His Val Ala Arg Thr Phe Leu Leu Met
        195                 200                 205
Pro Arg Gly His Ile Pro Tyr Pro Leu Pro Pro Asn Tyr Ser Tyr Gly
    210                 215                 220
Leu Cys Pro Gly Asn Gly Thr Thr Lys Glu Glu Lys Glu Thr Ala Glu
225                 230                 235                 240
His Glu Asn Arg Glu Leu Gln Ser Lys Glu Phe Leu Ser Ala Lys Glu
                245                 250                 255
Glu Thr Pro Gly Ala Gly Gln Lys Gln Glu Leu Arg Ser Phe Trp Ser
            260                 265                 270
Tyr Ala Phe Ser Arg Arg Phe Ala Trp His Leu Val Trp Leu Ser Val
        275                 280                 285
Ile Gln Leu Trp His Tyr Leu Phe Ile Gly Thr Leu Asn Ser Leu Leu
    290                 295                 300
Thr Asn Met Ala Gly Gly Asp Met Ala Arg Val Ser Thr Tyr Thr Asn
305                 310                 315                 320
Ala Phe Ala Phe Thr Gln Phe Gly Val Leu Cys Ala Pro Trp Asn Gly
                325                 330                 335
Leu Leu Met Asp Arg Leu Lys Gln Lys Tyr Gln Lys Glu Ala Arg Lys
            340                 345                 350
Thr Gly Ser Ser Thr Leu Ala Val Ala Leu Cys Ser Thr Val Pro Ser
        355                 360                 365
Leu Ala Leu Thr Ser Leu Leu Cys Leu Gly Phe Ala Leu Cys Ala Ser
    370                 375                 380
Val Pro Ile Leu Pro Leu Gln Tyr Leu Thr Phe Ile Leu Gln Val Ile
385                 390                 395                 400
Ser Arg Ser Phe Leu Tyr Gly Ser Asn Ala Ala Phe Leu Thr Leu Ala
                405                 410                 415
Phe Pro Ser Glu His Phe Gly Lys Leu Phe Gly Leu Val Met Ala Leu
            420                 425                 430
Ser Ala Val Val Ser Leu Leu Gln Phe Pro Ile Phe Thr Leu Ile Lys
        435                 440                 445
Gly Ser Leu Gln Asn Asp Pro Phe Tyr Val Asn Val Met Phe Met Leu
    450                 455                 460
Ala Ile Leu Leu Thr Phe Phe His Pro Phe Leu Val Tyr Arg Glu Cys
465                 470                 475                 480
Arg Thr Trp Lys Glu Ser Pro Ser Ala Ile Ala
                485                 490

<210> 65
<211> 519
<212> PRT
<213> Homo sapiens

<400> 65
Met Ser Tyr Pro Gln Phe Gly Tyr Pro Tyr Ser Ser Ala Pro Gln Phe
 1               5                  10                  15
Leu Met Ala Thr Asn Ser Leu Ser Thr Cys Cys Glu Ser Gly Gly Arg
            20                  25                  30
Thr Leu Ala Asp Ser Gly Pro Ala Ala Ser Ala Gln Ala Pro Val Tyr
        35                  40                  45
Cys Pro Val Tyr Glu Ser Arg Leu Leu Ala Thr Ala Arg His Glu Leu
    50                  55                  60
Asn Ser Ala Ala Ala Leu Gly Val Tyr Gly Gly Pro Tyr Gly Gly Ser
65                  70                  75                  80
Gln Gly Tyr Gly Asn Tyr Val Thr Tyr Gly Ser Glu Ala Ser Ala Phe
                85                  90                  95
Tyr Ser Leu Asn Ser Phe Asp Ser Lys Asp Gly Ser Gly Ser Ala His
            100                 105                 110
Gly Gly Leu Ala Pro Ala Ala Ala Ala Tyr Tyr Pro Tyr Glu Pro Ala
        115                 120                 125
Leu Gly Gln Tyr Pro Tyr Asp Arg Tyr Gly Thr Met Asp Ser Gly Thr
    130                 135                 140
Arg Arg Lys Asn Ala Thr Arg Glu Thr Thr Ser Thr Leu Lys Ala Trp
145                 150                 155                 160
Leu Gln Glu His Arg Lys Asn Pro Tyr Pro Thr Lys Gly Glu Lys Ile
                165                 170                 175
Met Leu Ala Ile Ile Thr Lys Met Thr Leu Thr Gln Val Ser Thr Trp
            180                 185                 190
Phe Ala Asn Ala Arg Arg Arg Leu Lys Lys Glu Asn Lys Met Thr Trp
        195                 200                 205
Pro Pro Arg Asn Lys Cys Ala Asp Glu Lys Arg Pro Tyr Ala Glu Gly
    210                 215                 220
Glu Glu Glu Glu Gly Gly Glu Glu Glu Ala Arg Glu Glu Pro Leu Lys
225                 230                 235                 240
Ser Ser Lys Asn Ala Glu Pro Val Gly Lys Glu Glu Lys Glu Leu Glu
                245                 250                 255
Leu Ser Asp Leu Asp Asp Phe Asp Pro Leu Glu Ala Glu Pro Pro Ala
            260                 265                 270
Cys Glu Leu Lys Pro Pro Phe His Ser Leu Asp Gly Gly Leu Glu Arg
        275                 280                 285
Val Pro Ala Ala Pro Asp Gly Pro Val Lys Glu Ala Ser Gly Ala Leu
    290                 295                 300
Arg Met Ser Leu Ala Ala Gly Gly Gly Ala Ala Leu Asp Glu Asp Leu
305                 310                 315                 320
Glu Arg Ala Arg Ser Cys Leu Arg Ser Ala Ala Ala Gly Pro Glu Pro
                325                 330                 335
Leu Pro Gly Ala Glu Gly Gly Pro Gln Val Cys Glu Ala Lys Leu Gly
            340                 345                 350
Phe Val Pro Ala Gly Ala Ser Ala Gly Leu Glu Ala Lys Pro Arg Ile
        355                 360                 365
Trp Ser Leu Ala His Thr Ala Thr Ala Ala Ala Ala Ala Ala Thr Ser
    370                 375                 380
Leu Ser Gln Thr Glu Phe Pro Ser Cys Met Leu Lys Arg Gln Gly Pro
385                 390                 395                 400
Ala Ala Pro Ala Ala Val Ser Ser Ala Pro Ala Thr Ser Pro Ser Val
                405                 410                 415
Ala Leu Pro His Ser Gly Ala Leu Asp Arg His Gln Asp Ser Pro Val
            420                 425                 430
Thr Ser Leu Arg Asn Trp Val Asp Gly Val Phe His Asp Pro Ile Leu
        435                 440                 445
Arg His Ser Thr Leu Asn Gln Ala Trp Ala Thr Ala Lys Gly Ala Leu
    450                 455                 460
Leu Asp Pro Gly Pro Leu Gly Arg Ser Leu Gly Ala Gly Ala Asn Val
465                 470                 475                 480
Leu Thr Ala Pro Leu Ala Arg Ala Phe Pro Pro Ala Val Pro Gln Asp
                485                 490                 495
Ala Pro Ala Ala Gly Ala Ala Arg Glu Leu Leu Ala Leu Pro Lys Ala
            500                 505                 510
Gly Gly Lys Pro Phe Cys Ala
        515

<210> 66
<211> 9
<212> RNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 66
uucaagaga                                                               9

<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 67
ccaccgctgt ccaccgcctc                                                  20

<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 68
gacccaaggc cagcggccgc                                                  20

<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 69
ggagggagga gaaccagcag                                                  20

<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 70
aaattgcagc cggagcgcgg                                                  20

<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 71
tccggataaa ccgaggcacg                                                  20

<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 72
gcgaagcatc ttcaccaccc                                                  20

<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 73
gacccagcac tgcagcctgg                                                  20

<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 74
aaacttatgc ggcgtttcct                                                  20

<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 75
atcactttaa aaccacctct                                                  20

<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 76
ctgaaaaagg aaggagttga                                                  20

<210> 77
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 77
cgcgagcaca gctaaggcca                                                  20

<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 78
gagtagcgcg agcacagcta                                                  20

<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 79
ggccgagatg tctcgctccg                                                  20

<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 80
aacaaagcac cctccccact                                                  20

<210> 81
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 81
caaacaggcg tatctgtgtg                                                  20

<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 82
ctctgcaacc aggagcccag                                                  20

<210> 83
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 83
cactgttgtc ttatcagacg                                                  20

<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 84
ctcgtctgat aagacaacag                                                  20

<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 85
gtttgttctt agggtaacag                                                  20

<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 86
actcagccat tttattagaa                                                  20

<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 87
gagcagcctg tctttatcgg                                                  20

<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 88
gttctccggg cccctcctac                                                  20

<210> 89
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 89
cgcctggtgc gcgcccgttg                                                  20

<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 90
gaggccacac tgcagcgcgg                                                  20

<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 91
tgggtctgtc tcatcgtcaa                                                  20

<210> 92
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 92
gtggcacagg tgggcataat                                                  20

<210> 93
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 93
gggtggagag ttgggacacc                                                  20

<210> 94
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 94
gctcggctgg gccagtccgc                                                  20

<210> 95
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 95
tccattcagt cagtctttgg                                                  20

<210> 96
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 96
gagagctatc acctaagtgt                                                  20

<210> 97
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 97
tatctggccc tgggtgcttg                                                  20

<210> 98
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 98
ggtgccgccc ccagcgtagg                                                  20

<210> 99
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 99
gacaggctca gctatgaaga                                                  20

<210> 100
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 100
gcggcagtgc ggcggatgta                                                  20

<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 101
tccccctcca gctgcaacgg                                                  20

<210> 102
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 102
ggaggactac caagaggggg                                                  20

<210> 103
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 103
acagtcgtgc agtgcagctg                                                  20

<210> 104
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 104
ggggctctga gagcctctga                                                  20

<210> 105
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 105
gagtcaacgg ggaataccat                                                  20

<210> 106
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 106
gaaccattag atcaatgcga                                                  20

<210> 107
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 107
ggggagcggc gctaaaggcg                                                  20

<210> 108
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 108
gaaaacacgg ggtcacgcgc                                                  20

<210> 109
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 109
acctgcaccc gcggccgttg                                                  20

<210> 110
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 110
gccgagtccc gcaggcgggg                                                  20

<210> 111
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 111
ttgggagtgg tcggattggt                                                  20

<210> 112
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 112
ggcacaaggc agccagatct                                                  20

<210> 113
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 113
aaagggtgtg tggagaaatg                                                  20

<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 114
gagcgcgcaa ccaggaccac                                                  20

<210> 115
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 115
ccaggcctgt gtcgagtggg                                                  20

<210> 116
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 116
gaggaggagc catggggcgg                                                  20

<210> 117
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 117
ggaagtagaa tgtgcctgga t                                                21

<210> 118
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 118
gagaccacag ttagagaacc ac                                               22

<210> 119
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 119
cgacagttca gccatcactt                                                  20

<210> 120
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 120
cactgttttt ccaagacctc a                                                21

<210> 121
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 121
ctccagaggt ttgagttctt ct                                               22

<210> 122
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 122
gcgaagagag ccacttctg                                                   19

<210> 123
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 123
ctggtgttgc ctcttgtgat                                                  20

<210> 124
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 124
cagcttggac actggatctc                                                  20

<210> 125
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 125
aagcagacgg aaagtgagg                                                   19

<210> 126
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 126
gatcctcaag tactttcagc ca                                               22

<210> 127
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 127
tgatctccaa gtctgtctgc                                                  20

<210> 128
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 128
acaacttcgt gcactcca                                                    18

<210> 129
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 129
tctgcgtgaa tcctagattt ctg                                              23

<210> 130
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 130
gccgaacttc tcacagca                                                    18

<210> 131
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 131
gtttttgatc cagacccaga tg                                               22

<210> 132
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 132
caagactgag atgcacaagt g                                                21

<210> 133
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 133
gtaagcagga agagaagcca                                                  20

<210> 134
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 134
tcttgctatt gaccgatgct t                                                21

<210> 135
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 135
gcaacaaaaa gaaacgagat gac                                              23

<210> 136
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 136
ttcctgctat gattttctcc ca                                               22

<210> 137
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 137
aaactcacca ggatgctcac                                                  20

<210> 138
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 138
gtgtacttgc tgatcaactg c                                                21

<210> 139
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 139
agtgtcagtg gtgttggc                                                    18

<210> 140
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 140
cctgcacggc tacattgag                                                   19

<210> 141
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 141
gtggctatgg ttggaggtc                                                   19

<210> 142
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 142
cactgccgag gaatgaagag                                                  20

<210> 143
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 143
gagtcctttc gtttccagca                                                  20

<210> 144
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 144
cagcctctgc ctcaatgg                                                    18

<210> 145
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 145
gctgagaagt tggaagtgga a                                                21

<210> 146
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 146
cttaacaacc tgctacccca t                                                21

<210> 147
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 147
gcccattatt cagagcgagt a                                                21

<210> 148
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 148
gtggcggatt tgatcatttg g                                                21

<210> 149
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 149
ccacagatca gaaacccgat gaaggc                                           26

<210> 150
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 150
taaagctgta gcccgttgcc tgc                                              23

<210> 151
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 151
tcggtaactg acttgaatgt ccaacgc                                          27

<210> 152
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 152
tctacctctg actgtgatat ttttgtgttt aaagtct                               37

<210> 153
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 153
ttacatgccc aagaaggcca caga                                             24

<210> 154
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 154
tgtaacaccc cagacccctc gaa                                              23

<210> 155
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 155
aggtgtgcgg gctcaggat                                                   19

<210> 156
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 156
cacttccgca tctgcccgtg                                                  20

<210> 157
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 157
tgtagcagct gatccgagcc taga                                             24

<210> 158
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 158
cgagggtgga ggcctgaatt ttga                                             24

<210> 159
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 159
tgcttctctc tctgtcttcg ggtga                                            25

<210> 160
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 160
acggtgttct gtttctcctg gca                                              23

<210> 161
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 161
agagagcaga ctggaagaaa acagtgg                                          27

<210> 162
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 162
cagatgtccc agttcctgtg cctt                                             24

<210> 163
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 163
tgcagggttt caccaggatc cac                                              23

<210> 164
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 164
aattcacgca gaaggaacca gacagt                                           26

<210> 165
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 165
gtttaagagc tatg                                                        14
