                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  OXYNTOMODULIN BINDING MOLECULES, AND USES THEREOF

<130>  X20957

<150>  63/139,428
<151>  2021-01-20

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Gly Tyr Thr Phe Thr Asp Tyr Ala Phe Ser 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Trp Ile Thr Thr Asn Thr Gly Glu Ala Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Glu Thr Glu Tyr Gly Asp Ser Ser Trp Phe Gly His 
1               5                   10          


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Arg Ala Ser Glu Ser Val Asp Gly Trp Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Leu Ala Thr Tyr Arg Val Ala 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Gln Ser Ser Glu Asp Pro Tyr Thr 
1               5                   


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Thr Thr Asn Thr Gly Glu Ala Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Thr Glu Tyr Gly Asp Ser Ser Trp Phe Gly His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Gly Trp 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Thr Tyr Arg Val Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Met Gln Ser Ser 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Thr Thr Asn Thr Gly Glu Ala Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Thr Glu Tyr Gly Asp Ser Ser Trp Phe Gly His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
    210                 215                 220                 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
                245                 250                 255     


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
            260                 265                 270         


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
        275                 280                 285             


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
    290                 295                 300                 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
        355                 360                 365             


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
    370                 375                 380                 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
                405                 410                 415     


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
            420                 425                 430         


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  10
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Gly Trp 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Thr Tyr Arg Val Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Met Gln Ser Ser 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
        115                 120                 125             


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
145                 150                 155                 160 


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
            180                 185                 190         


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
        195                 200                 205             


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215             


<210>  11
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
cagatccagt tggtacagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca gactatgcat ttagctgggt gaaacaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaccacta acactggaga agccacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca gcaacctcaa aaatgaggac acggctacat atttctgtgc aagagagacg      300

gaatacggtg atagctcctg gtttgggcac tggggccaag ggactctggt cactgtctct      360

gcagctaaaa caacagcccc atcggtctat ccgctagccc ctgtgtgtgg agatacaact      420

ggctcctcgg tgactctagg atgcctggtc aagggttatt tccctgagcc agtgaccttg      480

acctggaact ctggcagcct gtccagtggt gtgcacacct tcccagctgt cctgcagtct      540

gacctctaca ccctcagcag ctcagtgact gtaacgtcga gcacctggcc cagccagtcc      600

atcacctgca atgtggccca cccggcaagc agcaccaagg tggacaagaa aattgagccc      660

agagggccca caatcaagcc ctgtcctcca tgcaaatgcc cagcacctaa cctcttgggt      720

ggaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc      780

cccatagtca catgtgtggt ggtggatgtg agcgaggatg acccagatgt ccagatcagc      840

tggtttgtga acaacgtgga agtacacaca gctcagacac aaacccatag agaggattac      900

aacagtactc tccgggtggt cagtgccctc cccatccagc accaggactg gatgagtggc      960

aaggagttca aatgcaaggt caacaacaaa gacctcccag cgcccatcga gagaaccatc     1020

tcaaaaccca aagggtcagt aagagctcca caggtatatg tcttgcctcc accagaagaa     1080

gagatgacta agaaacaggt cactctgacc tgcatggtca cagacttcat gcctgaagac     1140

atttacgtgg agtggaccaa caacgggaaa acagagctaa actacaagaa cactgaacca     1200

gtcctggact ctgatggttc ttacttcatg tacagcaagc tgagagtgga aaagaagaac     1260

tgggtggaaa gaaatagcta ctcctgttca gtggtccacg agggtctgca caatcaccac     1320

acgactaaga gcttctcccg gactccgggt aaa                                  1353


<210>  12
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
gacattgtgc tgacccaatc tccagcttct ttggccgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat ggatggggca atagtttcat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc tcgctaccta tcgcgtagct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat tattgtatgc agagtagtga agatccgtac      300

acgttcggag gggggaccaa gctggaaata aaacgggctg atgcggcgcc cactgtatcc      360

atcttcccac catccagtga gcagttaaca tctggaggtg ctagcgtcgt gtgcttcttg      420

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      480

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      540

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      600

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgt            654


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Gly Tyr Asn Phe Thr Asn Tyr Trp Leu His 
1               5                   10  


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Glu Leu Asp Pro Glu Tyr Gly Phe Ala Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Gly Phe Met Asp Tyr 
1               5   


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Arg Ser Ser Arg Ser Leu Leu Asp Pro Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Trp Gln Gly Thr His Leu Pro Val Thr 
1               5                   


<210>  19
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Gln Val Gln Val Gln Gln Ser Gly Ala Glu Leu Val Met Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Leu Asp Pro Glu Tyr Gly Phe Ala Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ala Gly Phe Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  20
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Pro 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Arg Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Leu Pro Val Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Gln Val Gln Val Gln Gln Ser Gly Ala Glu Leu Val Met Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Leu Asp Pro Glu Tyr Gly Phe Ala Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ala Gly Phe Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val 
        115                 120                 125             


Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr 
                165                 170                 175     


Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln 
            180                 185                 190         


Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys 
    210                 215                 220                 


Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
225                 230                 235                 240 


Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 
            260                 265                 270         


Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 
        275                 280                 285             


His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro 
    290                 295                 300                 


Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 
305                 310                 315                 320 


Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro 
                325                 330                 335     


Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu 
            340                 345                 350         


Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp 
        355                 360                 365             


Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr 
    370                 375                 380                 


Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu 
                405                 410                 415     


Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His 
            420                 425                 430         


His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 


<210>  22
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Pro 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Arg Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Leu Pro Val Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  23
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
caggtccaag tgcagcagtc tggggctgag cttgtgatgc ctgggacttc agtgaagctg       60

tcctgcaagg cctctggcta taacttcact aattattggt tacactgggt gaagcagagg      120

cctggacaag gccttgagtg gatcggagag ctcgaccctg aatatggttt tgcgaactac      180

aatcaaaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgttc tgccgggttc      300

atggactact ggggtcaagg aacctcagtc accgtctcct cagctaaaac aacagcccca      360

tcggtctatc cgctagcccc tgtgtgtgga gatacaactg gctcctcggt gactctagga      420

tgcctggtca agggttattt ccctgagcca gtgaccttga cctggaactc tggcagcctg      480

tccagtggtg tgcacacctt cccagctgtc ctgcagtctg acctctacac cctcagcagc      540

tcagtgactg taacgtcgag cacctggccc agccagtcca tcacctgcaa tgtggcccac      600

ccggcaagca gcaccaaggt ggacaagaaa attgagccca gagggcccac aatcaagccc      660

tgtcctccat gcaaatgccc agcacctaac ctcttgggtg gaccatccgt cttcatcttc      720

cctccaaaga tcaaggatgt actcatgatc tccctgagcc ccatagtcac atgtgtggtg      780

gtggatgtga gcgaggatga cccagatgtc cagatcagct ggtttgtgaa caacgtggaa      840

gtacacacag ctcagacaca aacccataga gaggattaca acagtactct ccgggtggtc      900

agtgccctcc ccatccagca ccaggactgg atgagtggca aggagttcaa atgcaaggtc      960

aacaacaaag acctcccagc gcccatcgag agaaccatct caaaacccaa agggtcagta     1020

agagctccac aggtatatgt cttgcctcca ccagaagaag agatgactaa gaaacaggtc     1080

actctgacct gcatggtcac agacttcatg cctgaagaca tttacgtgga gtggaccaac     1140

aacgggaaaa cagagctaaa ctacaagaac actgaaccag tcctggactc tgatggttct     1200

tacttcatgt acagcaagct gagagtggaa aagaagaact gggtggaaag aaatagctac     1260

tcctgttcag tggtccacga gggtctgcac aatcaccaca cgactaagag cttctcccgg     1320

actccgggta aa                                                         1332


<210>  24
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
gatgttgtga tgacccagac tccactcact ttgtcggtta acattggaca accagcctcc       60

atctcttgca ggtcaagtcg gagcctctta gatccagatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctagagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acatcttcct      300

gtaacgttcg gtggaggcac caagctggaa atcaaacggg ctgatgcggc gcccactgta      360

tccatcttcc caccatccag tgagcagtta acatctggag gtgctagcgt cgtgtgcttc      420

ttgaacaact tctaccccaa agacatcaat gtcaagtgga agattgatgg cagtgaacga      480

caaaatggcg tcctgaacag ttggactgat caggacagca aagacagcac ctacagcatg      540

agcagcaccc tcacgttgac caaggacgag tatgaacgac ataacagcta tacctgtgag      600

gccactcaca agacatcaac ttcacccatt gtcaagagct tcaacaggaa tgagtgt         657


<210>  25
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  25

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  26
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg 
1               5                   10                  15      


Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn Arg Asn 
            20                  25                  30          


Asn Ile Ala 
        35  


<210>  27
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala 
1               5                   10                  15      


Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn Arg Asn Asn 
            20                  25                  30          


Ile Ala 
        


<210>  28
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser Phe Ser Ala Ser 
1               5                   10                  15      


Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn Glu Asp Lys Arg 
            20                  25                  30          


His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
        35                  40                  45              


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
    50                  55                  60                  


Arg Asn Asn Ile Ala 
65                  


<210>  29
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
1               5                   10                  15      


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
            20                  25                  30          


Thr Lys Arg Asn Arg Asn Asn Ile Ala 
        35                  40      


<210>  30
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  30

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  31
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg 
1               5                   10                  15      


Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25          


<210>  32
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala 
1               5                   10                  15      


Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25      


<210>  33
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  33

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  34
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  34

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  35
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  35

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala 
1               5                   10                  15      


Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  


<210>  36
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


