                         SEQUENCE LISTING

<110>  ETH Zrich, Universitt Zrich
 
<120>  Bispecific antibody that binds to CD3 and a fluorophore

<130>  ED41635

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  1

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  2
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  2

Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   


<210>  3
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  3

Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
1               5                   10                  


<210>  4
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  4

Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  5

Gly Tyr Thr Phe Thr Arg Tyr 
1               5           


<210>  6
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  6

Asn Pro Ser Arg Gly Tyr 
1               5       


<210>  7
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  7

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  8
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  9
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  9

Ser Ser Val Ser Tyr Met Asn 
1               5           


<210>  10
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  10

Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
1               5                   10      


<210>  11
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  11

Gln Gln Trp Ser Ser Asn Pro Leu 
1               5               


<210>  12
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  12

Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  13
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  13

Asp Thr Ser Lys Val Ala Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  14

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  15
<211>  243
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  15

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
                165                 170                 175     


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
            180                 185                 190         


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  16
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  17
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  17

Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   


<210>  18
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  18

Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
1               5                   10                  


<210>  19
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  19

Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10      


<210>  20
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  20

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105         


<210>  21
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  21

Ser Ser Val Ser Tyr Met Asn 
1               5           


<210>  22
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  22

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  23
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  23

Gln Gln Trp Ser Ser Asn Pro Phe 
1               5               


<210>  24
<211>  244
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  24

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Val Asp Gln Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
                165                 170                 175     


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Asn Arg 
                


<210>  25
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  25

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  26
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  26

Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Val Asp 
        


<210>  27
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  27

Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125     


<210>  28
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  28

Phe Thr Phe Gly Ser Phe Ser Met Ser 
1               5                   


<210>  29
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  29

Trp Val Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr 
1               5                   10                  


<210>  30
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  30

Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser Tyr Met 
1               5                   10                  15      


Asp Val Trp 
            


<210>  31
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  31

Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met 
        35                  40                  45              


Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Glu Phe Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  32
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  32

Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10  


<210>  33
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  33

Leu Met Ile Tyr Asp Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  34

Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe Leu 
1               5                   10      


<210>  35
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  35

Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val 
    130                 135                 140                 


Leu Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr 
145                 150                 155                 160 


Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
            180                 185                 190         


Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe 
225                 230                 235                 240 


Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  36
<211>  114
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  36

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Ser Ser 
        


<210>  37
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  37

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg 
1               5                   10              


<210>  38
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  38

Leu Ile Tyr Lys Val Ser Asn Arg Val Ser 
1               5                   10  


<210>  39
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  39

Ser Gln Ser Thr His Val Pro Trp 
1               5               


<210>  40
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  40

Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ala 
1               5                   10                  15      


Met Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr Trp 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr 
                85                  90                  95      


Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  41
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  41

Phe Thr Phe Gly His Tyr Trp Met Asn 
1               5                   


<210>  42
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  42

Trp Val Ala Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr 
1               5                   10                  15      


<210>  43
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  43

Gly Ala Ser Tyr Gly Met Glu Tyr Leu 
1               5                   


<210>  44
<211>  254
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  44

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
        115                 120                 125             


Lys Lys Asp Asp Ala Lys Lys Asp Gly Gly Val Lys Leu Asp Glu Thr 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ala Met Lys Leu Ser Cys Val 
145                 150                 155                 160 


Thr Ser Gly Phe Thr Phe Gly His Tyr Trp Met Asn Trp Val Arg Gln 
                165                 170                 175     


Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Gln Phe Arg Asn Lys Pro 
            180                 185                 190         


Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn 
    210                 215                 220                 


Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Gly Ala Ser Tyr 
225                 230                 235                 240 


Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser Val Thr Val Ser 
                245                 250                 


<210>  45
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  45

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  46
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  46

Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala Lys Lys 
1               5                   10                  15      


Asp Asp Ala Lys Lys Asp Gly Gly 
            20                  


<210>  47
<211>  184
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  47

Asp Val Tyr His Asp Gly Ala Cys Pro Glu Val Lys Pro Val Asp Asn 
1               5                   10                  15      


Phe Asp Trp Ser Gln Tyr His Gly Lys Trp Trp Glu Val Ala Lys Tyr 
            20                  25                  30          


Pro Ser Pro Asn Gly Lys Tyr Gly Lys Cys Gly Trp Ile Glu Tyr Thr 
        35                  40                  45              


Pro Glu Gly Lys Ser Val Lys Val Ser Arg Tyr Asp Val Ile His Gly 
    50                  55                  60                  


Lys Glu Tyr Phe Met Glu Gly Thr Ala Tyr Pro Val Gly Asp Ser Lys 
65                  70                  75                  80  


Ile Gly Lys Ile Tyr His Ser Arg Thr Val Gly Gly Tyr Thr Lys Lys 
                85                  90                  95      


Thr Val Phe Asn Val Leu Ser Thr Asp Asn Lys Asn Tyr Ile Ile Gly 
            100                 105                 110         


Tyr Arg Cys Arg Tyr Asp Glu Asp Lys Lys Gly His Trp Asp His Val 
        115                 120                 125             


Trp Val Leu Ser Arg Ser Met Val Leu Thr Gly Glu Ala Lys Thr Ala 
    130                 135                 140                 


Val Glu Asn Tyr Leu Ile Gly Ser Pro Val Val Asp Ser Gln Lys Leu 
145                 150                 155                 160 


Val Tyr Ser Asp Phe Ser Glu Ala Ala Cys Lys Val Asn Asn Ser Asn 
                165                 170                 175     


Trp Ser His Pro Gln Phe Glu Lys 
            180                 


<210>  48
<211>  505
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  48

Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val 
    130                 135                 140                 


Leu Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr 
145                 150                 155                 160 


Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
            180                 185                 190         


Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe 
225                 230                 235                 240 


Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 
                245                 250                 255     


Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
        275                 280                 285             


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
305                 310                 315                 320 


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
                325                 330                 335     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                405                 410                 415     


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
            420                 425                 430         


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
        435                 440                 445             


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
                485                 490                 495     


Glu Leu Lys His His His His His His 
            500                 505 


<210>  49
<211>  508
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  49

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
        115                 120                 125             


Lys Lys Asp Asp Ala Lys Lys Asp Gly Gly Val Lys Leu Asp Glu Thr 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ala Met Lys Leu Ser Cys Val 
145                 150                 155                 160 


Thr Ser Gly Phe Thr Phe Gly His Tyr Trp Met Asn Trp Val Arg Gln 
                165                 170                 175     


Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Gln Phe Arg Asn Lys Pro 
            180                 185                 190         


Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn 
    210                 215                 220                 


Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Gly Ala Ser Tyr 
225                 230                 235                 240 


Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser Val Thr Val Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            260                 265                 270         


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        275                 280                 285             


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    290                 295                 300                 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
305                 310                 315                 320 


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
                325                 330                 335     


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu 
385                 390                 395                 400 


Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr 
                405                 410                 415     


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            420                 425                 430         


Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
        435                 440                 445             


Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly 
                485                 490                 495     


Thr Lys Leu Glu Leu Lys His His His His His His 
            500                 505             


<210>  50
<211>  438
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  50

Asp Val Tyr His Asp Gly Ala Cys Pro Glu Val Lys Pro Val Asp Asn 
1               5                   10                  15      


Phe Asp Trp Ser Gln Tyr His Gly Lys Trp Trp Glu Val Ala Lys Tyr 
            20                  25                  30          


Pro Ser Pro Asn Gly Lys Tyr Gly Lys Cys Gly Trp Ile Glu Tyr Thr 
        35                  40                  45              


Pro Glu Gly Lys Ser Val Lys Val Ser Arg Tyr Asp Val Ile His Gly 
    50                  55                  60                  


Lys Glu Tyr Phe Met Glu Gly Thr Ala Tyr Pro Val Gly Asp Ser Lys 
65                  70                  75                  80  


Ile Gly Lys Ile Tyr His Ser Arg Thr Val Gly Gly Tyr Thr Lys Lys 
                85                  90                  95      


Thr Val Phe Asn Val Leu Ser Thr Asp Asn Lys Asn Tyr Ile Ile Gly 
            100                 105                 110         


Tyr Arg Cys Arg Tyr Asp Glu Asp Lys Lys Gly His Trp Asp His Val 
        115                 120                 125             


Trp Val Leu Ser Arg Ser Met Val Leu Thr Gly Glu Ala Lys Thr Ala 
    130                 135                 140                 


Val Glu Asn Tyr Leu Ile Gly Ser Pro Val Val Asp Ser Gln Lys Leu 
145                 150                 155                 160 


Val Tyr Ser Asp Phe Ser Glu Ala Ala Cys Lys Val Asn Asn Ser Asn 
                165                 170                 175     


Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Asp Ile Lys 
            180                 185                 190         


Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys 
        195                 200                 205             


Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
    210                 215                 220                 


Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
225                 230                 235                 240 


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys 
                245                 250                 255     


Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
            260                 265                 270         


Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr 
        275                 280                 285             


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
    290                 295                 300                 


Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile 
                325                 330                 335     


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            340                 345                 350         


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
        355                 360                 365             


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro 
    370                 375                 380                 


Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
385                 390                 395                 400 


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                405                 410                 415     


Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            420                 425                 430         


His His His His His His 
        435             


<210>  51
<211>  265
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  51

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
                165                 170                 175     


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
            180                 185                 190         


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                245                 250                 255     


Gly Ser His His His His His His Cys 
            260                 265 


<210>  52
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  52

Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Val 
            20                  25                  30          


Tyr Met Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Ser Ile Tyr Pro Tyr Ser Gly Tyr Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Tyr Val Tyr His Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  53
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  53

Phe Asn Ile Ser Val Tyr Met Met His 
1               5                   


<210>  54
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  54

Trp Val Ala Ser Ile Tyr Pro Tyr Ser Gly Tyr Thr Tyr Tyr 
1               5                   10                  


<210>  55
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  55

Arg Tyr Val Tyr His Ala Leu Asp Tyr 
1               5                   


<210>  56
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  56

Gly Phe Asn Ile Ser Val Tyr 
1               5           


<210>  57
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  57

Tyr Pro Tyr Ser Gly Tyr 
1               5       


<210>  58
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  58

Tyr Val Tyr His Ala Leu Asp Tyr 
1               5               


<210>  59
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg Gly Leu Arg Asn 
            20                  25                  30          


Val Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ala Val His 
                85                  90                  95      


Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  60
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  60

Gln Arg Gly Leu Arg Asn Val Ala Val Ala 
1               5                   10  


<210>  61
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  61

Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser 
1               5                   10      


<210>  62
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  62

Gln Gln Trp Ala Val His Ser Leu Ile 
1               5                   


<210>  63
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  63

Arg Ala Ser Gln Arg Gly Leu Arg Asn Val Ala Val Ala 
1               5                   10              


<210>  64
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  64

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  65
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  65

Gln Gln Trp Ala Val His Ser Leu Ile Thr 
1               5                   10  


<210>  66
<211>  243
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg Gly Leu Arg Asn 
            20                  25                  30          


Val Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ala Val His 
                85                  90                  95      


Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Val Tyr Met Met 
145                 150                 155                 160 


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser 
                165                 170                 175     


Ile Tyr Pro Tyr Ser Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Tyr Val Tyr His Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  67
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  67

Gly Gly Gly Gly Ser 
1               5   


<210>  68
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Pro Pro Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  69
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  69

Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  70
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  70

Trp Val Ser Ala Ile Asp Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10                  15  


<210>  71
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  71

Val Lys Gly Pro Pro Val Phe Asp Tyr 
1               5                   


<210>  72
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  72

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Lys Trp Ser Trp Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  73
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  73

Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5               


<210>  74
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  74

Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser 
1               5                   10      


<210>  75
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence

<400>  75

Gln Ser Ser Lys Trp Ser Trp Asp Pro Val 
1               5                   10  


