                         SEQUENCE LISTING

<110>  Technische Universitt Dresden
 
<120>  Verfahren zur Herstellung von 2,4-Dihydroxybutyrat oder 
       L-Threonin unter Nutzung eines mikrobiellen Stoffwechselweges

<130>  TUD80-20-IP

<150>  DE102021101004.7
<151>  2021-01-19

<160>  184   

<170>  PatentIn version 3.5

<210>  1
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  1
taagcactcg aggtttaact ttaagaagga gatataccat ggctaacaga atgctggtga       60


<210>  2
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  2
tgcttatcta gattaccagg cggtatggta aagc                                   34


<210>  3
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  3
taagcactcg aggtttaact ttaagaagga gatataccat ggctaacaga atgattctga       60


<210>  4
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  4
tgcttatcta gattaggacc ggaagtcga                                         29


<210>  5
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  5
taagcactcg aggtttaact ttaagaagga gatataccat ggctgataca atgctc           56


<210>  6
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  6
taagcactcg agtgtgtgaa attgttatcc g                                      31


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  7
ttcgagctcg gtaccc                                                       16


<210>  8
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  8
taagcaggat ccgtttaact ttaagaagga gatataccat ggaactgtat ctggatactt       60

cag                                                                     63


<210>  9
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  9
tgcttatcta gattaaatcg acgttctgcc aaac                                   34


<210>  10
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  10
tgcttaattt aaatttaaat cgacgttctg ccaaac                                 36


<210>  11
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  11
taagcaattt aaatgtttaa ctttaagaag gagatatacc atgtctaccg atagtttaca       60

acag                                                                    64


<210>  12
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  12
tgcttatcta gattatgccg gaaccggtg                                         29


<210>  13
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  13
taagcaggta ccgtttaact ttaagaagga gatataccat ggctgataca atgctc           56


<210>  14
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  14
tgcttaggat ccttaggacc ggaagtcgag                                        30


<210>  15
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  15
taagcaggta ccgtttaact ttaagaagga gatataccat gcgcaaactg cttggcag         58


<210>  16
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  16
tgcttagtcg acttagaacc ccagtccttt ggttttcg                               38


<210>  17
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  17
taagcagagc tcgtttaact ttaagaagga gatataccat gaaagtcgca gtcctc           56


<210>  18
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  18
tgcttaggat ccttacttat taacgaactc ttcgc                                  35


<210>  19
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  19
taagcaggat ccgtttaact ttaagaagga gatataccat gtcgactgat gcactggc         58


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  20
tgcttatcta gatcacatca ccgcgccgag                                        30


<210>  21
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  21
taagcaggat ccgtttaact ttaagaagga gatataccat gaaagccaac tctcccg          57


<210>  22
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  22
tgcttatcta gatcaggtgt agacgccgat g                                      31


<210>  23
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  23
taagcaggat ccgtttaact ttaagaagga gatataccat gcagatttct atcaaacgcg       60

cca                                                                     63


<210>  24
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  24
tgcttaaagc tttcatgcgg cggtcctca                                         29


<210>  25
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  25
taagcaattt aaatgtttaa ctttaagaag gagatatacc atgaaggtca cagaaacacg       60

cc                                                                      62


<210>  26
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  26
tgcttatcta gatcatggcg cggctccg                                          28


<210>  27
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  27
taagcaattt aaatgtttaa ctttaagaag gagatatacc atgaatacac gtcgccaatt       60

cctgtctg                                                                68


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  28
tgcttatcta gatcatccag ccgccggcac                                        30


<210>  29
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  29
taagcaattt aaatgtttaa ctttaagaag gagatatacc atgaatcggc gcacagg          57


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  30
tgcttatcta gactaaacgg gctcgtgtgt                                        30


<210>  31
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  31
ggttctgcct atggcagcgc accggcaccg tcg                                    33


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  32
cgacggtgcc ggtgcgctgc cataggcaga acc                                    33


<210>  33
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  33
taagcaggat ccgtttaact ttaagaagga gatataccat gaaaaatgtt ataaagataa       60

atgaaaaaga taatg                                                        75


<210>  34
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  34
tgcttatcta gattatagtg ttacaccgtt tttaaatata gatatttc                    48


<210>  35
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  35
taagcaggat ccgtttaact ttaagaagga gatataccat gaagacctca acagcagac        59


<210>  36
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  36
tgcttatcta gatcaggtga tcgcgccgat c                                      31


<210>  37
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  37
tgtctttgct gatctgctac gtaccctctc atggaagtta ggagtctgac gtgtaggctg       60

gagctgcttc                                                              70


<210>  38
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  38
gatagggacg acgtggtgtt agctgtgcat atgaatatcc tccttag                     47


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  39
cacagctaac accacgtcgt                                                   20


<210>  40
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  40
aacccgacgc tcatattggc actggaagcc ggggcataaa ctttaaccat ataatacctc       60

ctaaagttaa acaaaattat ttgtag                                            86


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  41
attgccgaag tggatggtaa                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  42
gtgactacat ctccgagcaa                                                   20


<210>  43
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  43
tgcgacagta gcgtattgtg gcacaaaaat agacacaccg ggagttcatc gtgtaggctg       60

gagctgcttc                                                              70


<210>  44
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  44
cttaaaatga tcgatgtcag caggtaggca aaccaccatt ctaaggtcat ataatacctc       60

ctaaagttaa acaaaattat ttgtag                                            86


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  45
catggtaaaa gcagcaaacg cgt                                               23


<210>  46
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  46
tatgaatcgc cagtccggtc tga                                               23


<210>  47
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  47
taagcagagc tcgtttaact ttaagaagga gatataccat gtttgagaac attaccgc         58


<210>  48
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr Plasmidkonstruktion

<400>  48
tgcttaggat ccttacagca ctgccacaat c                                      31


<210>  49
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  49
agatatcata tggaactgta tctggatact tcagac                                 36


<210>  50
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  50
agatatgaat tcttaaatcg acgttctgcc aaacgc                                 36


<210>  51
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  51
agatatcata tgaaagtcgc agtcctcggc                                        30


<210>  52
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  52
agatatgaat tcttacttat taacgaactc ttcgcccag                              39


<210>  53
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  53
ctggtgccgc gcggcagcca tatgcgcaaa ctgcttggc                              39


<210>  54
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  54
gtcgacggag ctcgaattcg gatccttaga accccagtcc tttgg                       45


<210>  55
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  55
actttaagaa ggagatatac catgcgcaaa ctgcttgg                               38


<210>  56
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  56
ggtgctcgag tgcggccgca agcttgaacc ccagtccttt ggttttc                     47


<210>  57
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  57
actttaagaa ggagatatac catggaaccg agtcagaatc c                           41


<210>  58
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  58
actttaagaa ggagatatac catggaacgc gcagatc                                37


<210>  59
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  59
actttaagaa ggagatatac catgtggagc gaaggtcc                               38


<210>  60
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  60
cagccatatg tcttcttcag tagcctcaac cgaaaac                                37


<210>  61
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  61
gaattcggat ccttaatact ttaaattgtc caagtttgg                              39


<210>  62
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  62
cagccatatg gttaatgaaa aagtgaatcc attcgac                                37


<210>  63
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  63
agctcgaatt cttatatcat ttctggatga ggaatacc                               38


<210>  64
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  64
catcacagca gcggcctggt gccgcgcggc agccatatgt ctaccgatag tttacaacag       60

tttc                                                                    64


<210>  65
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  65
tgcggccgca agcttgtcga cggagctcga attcttatgc cggaaccggt gcac             54


<210>  66
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  66
catcacagca gcggcctggt gccgcgcggc agccatatga gtaatgccga aaaagcac         58


<210>  67
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  67
tgcggccgca agcttgtcga cggagctcga attcttaaaa attcaccggc tg               52


<210>  68
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  68
catcacagca gcggcctggt gccgcgcggc agccatatgt cttctactga acctgc           56


<210>  69
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  69
tgcggccgca agcttgtcga cggagctcga attcttacgg ggtcggaatt aag              53


<210>  70
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  70
catcacagca gcggcctggt gccgcgcggc agccatatgg agaacgtgaa tatggtg          57


<210>  71
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  71
tgcggccgca agcttgtcga cggagctcga attcttacgg ggtgataact tg               52


<210>  72
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  72
gcaggagcca tatggatctg aatctgcagg acaaggtcgt                             40


<210>  73
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  73
gcaggagcaa gctttcagac gagcgcacga tcgagatgcg tat                         43


<210>  74
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  74
agatatgcta gcatgcctaa gtaccgttcc gcc                                    33


<210>  75
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  75
agatatgaat tcttaacccc ccagtttcga tttatcg                                37


<210>  76
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  76
catcacagca gcggcctggt gccgcgcggc agccatatgc cggcaaaatt aaa              53


<210>  77
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  77
tgcggccgca agcttgtcga cggagctcga attcttaagc gggacgg                     47


<210>  78
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  78
catcacagca gcggcctggt gccgcgcggc agccatatgc gtaccattat cgc              53


<210>  79
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  79
tgcggccgca agcttgtcga cggagctcga attcttaggc tttggctt                    48


<210>  80
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  80
ctggtgccgc gcggcagcca tatgaacagt gcccccgac                              39


<210>  81
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  81
gtcgacggag ctcgaattcg gatcctcagg aacggttgat gtcg                        44


<210>  82
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  82
ctggtgccgc gcggcagcca tatgtccgtc cgcatcgtc                              39


<210>  83
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  83
gtcgacggag ctcgaattcg gatccttact ccgccagcgc ctt                         43


<210>  84
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  84
ctggtgccgc gcggcagcca tatgtcgact gatgcactgg c                           41


<210>  85
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  85
cggagctcga attcggatcc tcacatcacc gcgccgag                               38


<210>  86
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  86
ctggtgccgc gcggcagcca tatgaaagcc aactctcccg                             40


<210>  87
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  87
cggagctcga attcggatcc tcaggtgtag acgccgatg                              39


<210>  88
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  88
ctggtgccgc gcggcagcca tatgcaatac atcaagatcc atgc                        44


<210>  89
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz fr die Klonierung eines Zielgens in den 
       pET28-Expressionsvektor

<400>  89
gtcgacggag ctcgaattcg gatccttata gcgttacgcc gcttttg                     47


<210>  90
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  90
tcagaactct ctctgtatgg catcgctcca gtgactcccg g                           41


<210>  91
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  91
ccgggagtca ctggagcgat gccatacaga gagagttctg a                           41


<210>  92
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  92
gaactctctc tgtatgattc tgctccagtg actcccggtg                             40


<210>  93
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  93
caccgggagt cactggagca gaatcataca gagagagttc                             40


<210>  94
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  94
gaactctctc tgtatggctc tgctccagtg actcccggtg                             40


<210>  95
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  95
caccgggagt cactggagca gagccataca gagagagttc                             40


<210>  96
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  96
gaactctctc tgtatggcaa agctccagtg actcccggtg                             40


<210>  97
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  97
caccgggagt cactggagct ttgccataca gagagagttc                             40


<210>  98
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  98
gaactctctc tgtatggccg tgctccagtg actcccggtg                             40


<210>  99
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  99
caccgggagt cactggagca cggccataca gagagagttc                             40


<210>  100
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  100
gaactctctc tgtatggcac cgctccagtg actcccggtg                             40


<210>  101
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primersequenz zum Einbringen von Mutationen in Enzym Ec.Mdh5Q

<400>  101
caccgggagt cactggagcg gtgccataca gagagagttc                             40


<210>  102
<211>  1149
<212>  DNA
<213>  Escherichia coli

<400>  102
atggctaaca gaatgattct gaacgaaacg gcatggtttg gtcggggtgc tgttggggct       60

ttaaccgatg aggtgaaacg ccgtggttat cagaaggcgc tgatcgtcac cgataaaacg      120

ctggtgcaat gcggcgtggt ggcgaaagtg accgataaga tggatgctgc agggctggca      180

tgggcgattt acgacggcgt agtgcccaac ccaacaatta ctgtcgtcaa agaagggctc      240

ggtgtattcc agaatagcgg cgcggattac ctgatcgcta ttggtggtgg ttctccacag      300

gatacttgta aagcgattgg cattatcagc aacaacccgg agtttgccga tgtgcgtagc      360

ctggaagggc tttccccgac caataaaccc agtgtaccga ttctggcaat tcctaccaca      420

gcaggtactg cggcagaagt gaccattaac tacgtgatca ctgacgaaga gaaacggcgc      480

aagtttgttt gcgttgatcc gcatgatatc ccgcaggtgg cgtttattga cgctgacatg      540

atggatggta tgcctccagc gctgaaagct gcgacgggtg tcgatgcgct cactcatgct      600

attgaggggt atattacccg tggcgcgtgg gcgctaaccg atgcactgca cattaaagcg      660

attgaaatca ttgctggggc gctgcgagga tcggttgctg gtgataagga tgccggagaa      720

gaaatggcgc tcgggcagta tgttgcgggt atgggcttct cgaatgttgg gttagggttg      780

gtgcatggta tggcgcatcc actgggcgcg ttttataaca ctccacacgg tgttgcgaac      840

gccatcctgt taccgcatgt catgcgttat aacgctgact ttaccggtga gaagtaccgc      900

gatatcgcgc gcgttatggg cgtgaaagtg gaaggtatga gcctggaaga ggcgcgtaat      960

gccgctgttg aagcggtgtt tgctctcaac cgtgatgtcg gtattccgcc acatttgcgt     1020

gatgttggtg tacgcaagga agacattccg gcactggcgc aggcggcact ggatgatgtt     1080

tgtaccggtg gcaacccgcg tgaagcaacg cttgaggata ttgtagagct ttaccatacc     1140

gcctggtaa                                                             1149


<210>  103
<211>  382
<212>  PRT
<213>  Escherichia coli

<400>  103

Met Ala Asn Arg Met Ile Leu Asn Glu Thr Ala Trp Phe Gly Arg Gly 
1               5                   10                  15      


Ala Val Gly Ala Leu Thr Asp Glu Val Lys Arg Arg Gly Tyr Gln Lys 
            20                  25                  30          


Ala Leu Ile Val Thr Asp Lys Thr Leu Val Gln Cys Gly Val Val Ala 
        35                  40                  45              


Lys Val Thr Asp Lys Met Asp Ala Ala Gly Leu Ala Trp Ala Ile Tyr 
    50                  55                  60                  


Asp Gly Val Val Pro Asn Pro Thr Ile Thr Val Val Lys Glu Gly Leu 
65                  70                  75                  80  


Gly Val Phe Gln Asn Ser Gly Ala Asp Tyr Leu Ile Ala Ile Gly Gly 
                85                  90                  95      


Gly Ser Pro Gln Asp Thr Cys Lys Ala Ile Gly Ile Ile Ser Asn Asn 
            100                 105                 110         


Pro Glu Phe Ala Asp Val Arg Ser Leu Glu Gly Leu Ser Pro Thr Asn 
        115                 120                 125             


Lys Pro Ser Val Pro Ile Leu Ala Ile Pro Thr Thr Ala Gly Thr Ala 
    130                 135                 140                 


Ala Glu Val Thr Ile Asn Tyr Val Ile Thr Asp Glu Glu Lys Arg Arg 
145                 150                 155                 160 


Lys Phe Val Cys Val Asp Pro His Asp Ile Pro Gln Val Ala Phe Ile 
                165                 170                 175     


Asp Ala Asp Met Met Asp Gly Met Pro Pro Ala Leu Lys Ala Ala Thr 
            180                 185                 190         


Gly Val Asp Ala Leu Thr His Ala Ile Glu Gly Tyr Ile Thr Arg Gly 
        195                 200                 205             


Ala Trp Ala Leu Thr Asp Ala Leu His Ile Lys Ala Ile Glu Ile Ile 
    210                 215                 220                 


Ala Gly Ala Leu Arg Gly Ser Val Ala Gly Asp Lys Asp Ala Gly Glu 
225                 230                 235                 240 


Glu Met Ala Leu Gly Gln Tyr Val Ala Gly Met Gly Phe Ser Asn Val 
                245                 250                 255     


Gly Leu Gly Leu Val His Gly Met Ala His Pro Leu Gly Ala Phe Tyr 
            260                 265                 270         


Asn Thr Pro His Gly Val Ala Asn Ala Ile Leu Leu Pro His Val Met 
        275                 280                 285             


Arg Tyr Asn Ala Asp Phe Thr Gly Glu Lys Tyr Arg Asp Ile Ala Arg 
    290                 295                 300                 


Val Met Gly Val Lys Val Glu Gly Met Ser Leu Glu Glu Ala Arg Asn 
305                 310                 315                 320 


Ala Ala Val Glu Ala Val Phe Ala Leu Asn Arg Asp Val Gly Ile Pro 
                325                 330                 335     


Pro His Leu Arg Asp Val Gly Val Arg Lys Glu Asp Ile Pro Ala Leu 
            340                 345                 350         


Ala Gln Ala Ala Leu Asp Asp Val Cys Thr Gly Gly Asn Pro Arg Glu 
        355                 360                 365             


Ala Thr Leu Glu Asp Ile Val Glu Leu Tyr His Thr Ala Trp 
    370                 375                 380         


<210>  104
<211>  1149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Ec.FucO

<400>  104
atggctaaca gaatgctggt gaacgaaacg gcatggtttg gtcggggtgc tgttggggct       60

ttaaccgatg aggtgaaacg ccgtggttat cagaaggcgc tgatcgtcac cgataaaacg      120

ctggtgcaat gcggcgtggt ggcgaaagtg accgataaga tggatgctgc agggctggca      180

tgggcgattt acgacggcgt agtgcccaac ccaacaatta ctgtcgtcaa agaagggctc      240

ggtgtattcc agaatagcgg cgcggattac ctgatcgcta ttggtggtgg ttctccacag      300

gatacttgta aagcgattgg cattatcagc aacaacccgg agtttgccga tgtgcgtagc      360

ctggaagggc tttccccgac caataaaccc agtgtaccga ttctggcaat tcctaccaca      420

gcaggtactg cggcagaagt gaccattaac tacgtgatca ctgacgaaga gaaacggcgc      480

aagtttgttt gcgttgatcc gcatgatatc ccgcaggtgg cgtttattga cgctgacatg      540

atggatggta tgcctccagc gctgaaagct gcgacgggtg tcgatgcgct cactcatgct      600

attgaggggt atattacccg tggcgcgtgg gcgctaaccg atgcactgca cattaaagcg      660

attgaaatca ttgctggggc gctgcgagga tcggttgctg gtgataagga tgccggagaa      720

gaaatggcgc tcgggcagta tgttgcgggt atgggcttct cgaatgttgg gttagggttg      780

gtgcatggta tggcgcatcc actgggcgcg ttttataaca ctccacacgg tgttgcgaac      840

gccatcctgt taccgcatgt catgcgttat aacgctgact ttaccggtga gaagtaccgc      900

gatatcgcgc gcgttatggg cgtgaaagtg gaaggtatga gcctggaaga ggcgcgtaat      960

gccgctgttg aagcggtgtt tgctctcaac cgtgatgtcg gtattccgcc acatttgcgt     1020

gatgttggtg tacgcaagga agacattccg gcactggcgc aggcggcact ggatgatgtt     1080

tgtaccggtg gcaacccgcg tgaagcaacg cttgaggata ttgtagagct ttaccatacc     1140

gcctggtaa                                                             1149


<210>  105
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Ec.FucO

<400>  105

Met Ala Asn Arg Met Leu Val Asn Glu Thr Ala Trp Phe Gly Arg Gly 
1               5                   10                  15      


Ala Val Gly Ala Leu Thr Asp Glu Val Lys Arg Arg Gly Tyr Gln Lys 
            20                  25                  30          


Ala Leu Ile Val Thr Asp Lys Thr Leu Val Gln Cys Gly Val Val Ala 
        35                  40                  45              


Lys Val Thr Asp Lys Met Asp Ala Ala Gly Leu Ala Trp Ala Ile Tyr 
    50                  55                  60                  


Asp Gly Val Val Pro Asn Pro Thr Ile Thr Val Val Lys Glu Gly Leu 
65                  70                  75                  80  


Gly Val Phe Gln Asn Ser Gly Ala Asp Tyr Leu Ile Ala Ile Gly Gly 
                85                  90                  95      


Gly Ser Pro Gln Asp Thr Cys Lys Ala Ile Gly Ile Ile Ser Asn Asn 
            100                 105                 110         


Pro Glu Phe Ala Asp Val Arg Ser Leu Glu Gly Leu Ser Pro Thr Asn 
        115                 120                 125             


Lys Pro Ser Val Pro Ile Leu Ala Ile Pro Thr Thr Ala Gly Thr Ala 
    130                 135                 140                 


Ala Glu Val Thr Ile Asn Tyr Val Ile Thr Asp Glu Glu Lys Arg Arg 
145                 150                 155                 160 


Lys Phe Val Cys Val Asp Pro His Asp Ile Pro Gln Val Ala Phe Ile 
                165                 170                 175     


Asp Ala Asp Met Met Asp Gly Met Pro Pro Ala Leu Lys Ala Ala Thr 
            180                 185                 190         


Gly Val Asp Ala Leu Thr His Ala Ile Glu Gly Tyr Ile Thr Arg Gly 
        195                 200                 205             


Ala Trp Ala Leu Thr Asp Ala Leu His Ile Lys Ala Ile Glu Ile Ile 
    210                 215                 220                 


Ala Gly Ala Leu Arg Gly Ser Val Ala Gly Asp Lys Asp Ala Gly Glu 
225                 230                 235                 240 


Glu Met Ala Leu Gly Gln Tyr Val Ala Gly Met Gly Phe Ser Asn Val 
                245                 250                 255     


Gly Leu Gly Leu Val His Gly Met Ala His Pro Leu Gly Ala Phe Tyr 
            260                 265                 270         


Asn Thr Pro His Gly Val Ala Asn Ala Ile Leu Leu Pro His Val Met 
        275                 280                 285             


Arg Tyr Asn Ala Asp Phe Thr Gly Glu Lys Tyr Arg Asp Ile Ala Arg 
    290                 295                 300                 


Val Met Gly Val Lys Val Glu Gly Met Ser Leu Glu Glu Ala Arg Asn 
305                 310                 315                 320 


Ala Ala Val Glu Ala Val Phe Ala Leu Asn Arg Asp Val Gly Ile Pro 
                325                 330                 335     


Pro His Leu Arg Asp Val Gly Val Arg Lys Glu Asp Ile Pro Ala Leu 
            340                 345                 350         


Ala Gln Ala Ala Leu Asp Asp Val Cys Thr Gly Gly Asn Pro Arg Glu 
        355                 360                 365             


Ala Thr Leu Glu Asp Ile Val Glu Leu Tyr His Thr Ala Trp 
    370                 375                 380         


<210>  106
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr Go.Adh

<400>  106
atggctgata caatgctcgc cgccgtcgtc cgtgaattcg gcaagccgct ctccatcgag       60

cggctaccca tcccggacat caagccccac cagatcctcg tgaaggtcga tacctgtggc      120

gtctgccaca ctgacctgca cgccgcgcgc ggggactggc cgtccaagcc caacccgccg      180

ttcattcccg ggcatgaagg cgtcggacac atcgtcgccg tcggcagtca ggtcggcgat      240

ttcgtcaaga ccggcgatgt cgtgggcgtg ccctggctct actccgcctg cggtcactgc      300

gaacactgtc tgggcggctg ggaaacactc tgcgaaaagc aggacgacac cggctacacc      360

gtcaatggct gcttcgccga atatgtcgtg gcagacccga actacgtcgc acacctgccc      420

tcgaccatcg acccgcttca ggcctcgccg gtcctgtgcg cggggctgac ggtctataag      480

ggcctgaaaa tgacggaggc ccgccccggc cagtgggtcg cagtctcggg cgtcggcggt      540

ctcggccaga tggccgtgca gtacgccgtc gccatgggca tgaatgtcgt cgcggtggac      600

atcgatgacg aaaaactcgc cacagccaaa aagctcggcg catccctgac cgtcaacgcc      660

aaggacacgg acccggccag gttcatccag cagcagatcg gcggcgcaca tggcgctctc      720

gtcaccgctg tcggacggac ggcgttttcg caggccatgg gctatgcccg ccgcggcggc      780

accatcgtcc tgaacggact gccgcccggc gatttcccgg tctcgatctt cgacatggtc      840

atgaacggca ccaccatccg tggctccatc gtcggaacac ggctggacat gatcgaggcc      900

atggatttct tcgcccgcgg caaggtcaaa tccgtcgtca cccccggaaa acttgaaaac      960

atcaatacga tcttcgacga tctgcagaat ggtcgcctcg aaggccggac agtgctcgac     1020

ttccggtcct aa                                                         1032


<210>  107
<211>  343
<212>  PRT
<213>  Gluconobacter oxydans

<400>  107

Met Ala Asp Thr Met Leu Ala Ala Val Val Arg Glu Phe Gly Lys Pro 
1               5                   10                  15      


Leu Ser Ile Glu Arg Leu Pro Ile Pro Asp Ile Lys Pro His Gln Ile 
            20                  25                  30          


Leu Val Lys Val Asp Thr Cys Gly Val Cys His Thr Asp Leu His Ala 
        35                  40                  45              


Ala Arg Gly Asp Trp Pro Ser Lys Pro Asn Pro Pro Phe Ile Pro Gly 
    50                  55                  60                  


His Glu Gly Val Gly His Ile Val Ala Val Gly Ser Gln Val Gly Asp 
65                  70                  75                  80  


Phe Val Lys Thr Gly Asp Val Val Gly Val Pro Trp Leu Tyr Ser Ala 
                85                  90                  95      


Cys Gly His Cys Glu His Cys Leu Gly Gly Trp Glu Thr Leu Cys Glu 
            100                 105                 110         


Lys Gln Asp Asp Thr Gly Tyr Thr Val Asn Gly Cys Phe Ala Glu Tyr 
        115                 120                 125             


Val Val Ala Asp Pro Asn Tyr Val Ala His Leu Pro Ser Thr Ile Asp 
    130                 135                 140                 


Pro Leu Gln Ala Ser Pro Val Leu Cys Ala Gly Leu Thr Val Tyr Lys 
145                 150                 155                 160 


Gly Leu Lys Met Thr Glu Ala Arg Pro Gly Gln Trp Val Ala Val Ser 
                165                 170                 175     


Gly Val Gly Gly Leu Gly Gln Met Ala Val Gln Tyr Ala Val Ala Met 
            180                 185                 190         


Gly Met Asn Val Val Ala Val Asp Ile Asp Asp Glu Lys Leu Ala Thr 
        195                 200                 205             


Ala Lys Lys Leu Gly Ala Ser Leu Thr Val Asn Ala Lys Asp Thr Asp 
    210                 215                 220                 


Pro Ala Arg Phe Ile Gln Gln Gln Ile Gly Gly Ala His Gly Ala Leu 
225                 230                 235                 240 


Val Thr Ala Val Gly Arg Thr Ala Phe Ser Gln Ala Met Gly Tyr Ala 
                245                 250                 255     


Arg Arg Gly Gly Thr Ile Val Leu Asn Gly Leu Pro Pro Gly Asp Phe 
            260                 265                 270         


Pro Val Ser Ile Phe Asp Met Val Met Asn Gly Thr Thr Ile Arg Gly 
        275                 280                 285             


Ser Ile Val Gly Thr Arg Leu Asp Met Ile Glu Ala Met Asp Phe Phe 
    290                 295                 300                 


Ala Arg Gly Lys Val Lys Ser Val Val Thr Pro Gly Lys Leu Glu Asn 
305                 310                 315                 320 


Ile Asn Thr Ile Phe Asp Asp Leu Gln Asn Gly Arg Leu Glu Gly Arg 
                325                 330                 335     


Thr Val Leu Asp Phe Arg Ser 
            340             


<210>  108
<211>  663
<212>  DNA
<213>  Escherichia coli

<400>  108
atggaactgt atctggatac ttcagacgtt gttgcggtga aggcgctgtc acgtattttt       60

ccgctggcgg gtgtgaccac taacccaagc attatcgccg cgggtaaaaa accgctggat      120

gttgtgcttc cgcaacttca tgaagcgatg ggcggtcagg ggcgtctgtt tgcccaggta      180

atggctacca ctgccgaagg gatggttaat gacgcgctta agctgcgttc tattattgcg      240

gatatcgtgg tgaaagttcc ggtgaccgcc gaggggctgg cagctattaa gatgttaaaa      300

gcggaaggga ttccgacgct gggaaccgcg gtatatggcg cagcacaagg gctgctgtcg      360

gcgctggcag gtgcggaata tgttgcgcct tacgttaatc gtattgatgc tcagggcggt      420

agcggcattc agactgtgac cgacttacac cagttattga aaatgcatgc gccgcaggcg      480

aaagtgctgg cagcgagttt caaaaccccg cgtcaggcgc tggactgctt actggcagga      540

tgtgaatcaa ttactctgcc actggatgtg gcacaacaga tgattagcta tccggcggtt      600

gatgccgctg tggcgaagtt tgagcaggac tggcagggag cgtttggcag aacgtcgatt      660

taa                                                                    663


<210>  109
<211>  220
<212>  PRT
<213>  Escherichia coli

<400>  109

Met Glu Leu Tyr Leu Asp Thr Ser Asp Val Val Ala Val Lys Ala Leu 
1               5                   10                  15      


Ser Arg Ile Phe Pro Leu Ala Gly Val Thr Thr Asn Pro Ser Ile Ile 
            20                  25                  30          


Ala Ala Gly Lys Lys Pro Leu Asp Val Val Leu Pro Gln Leu His Glu 
        35                  40                  45              


Ala Met Gly Gly Gln Gly Arg Leu Phe Ala Gln Val Met Ala Thr Thr 
    50                  55                  60                  


Ala Glu Gly Met Val Asn Asp Ala Leu Lys Leu Arg Ser Ile Ile Ala 
65                  70                  75                  80  


Asp Ile Val Val Lys Val Pro Val Thr Ala Glu Gly Leu Ala Ala Ile 
                85                  90                  95      


Lys Met Leu Lys Ala Glu Gly Ile Pro Thr Leu Gly Thr Ala Val Tyr 
            100                 105                 110         


Gly Ala Ala Gln Gly Leu Leu Ser Ala Leu Ala Gly Ala Glu Tyr Val 
        115                 120                 125             


Ala Pro Tyr Val Asn Arg Ile Asp Ala Gln Gly Gly Ser Gly Ile Gln 
    130                 135                 140                 


Thr Val Thr Asp Leu His Gln Leu Leu Lys Met His Ala Pro Gln Ala 
145                 150                 155                 160 


Lys Val Leu Ala Ala Ser Phe Lys Thr Pro Arg Gln Ala Leu Asp Cys 
                165                 170                 175     


Leu Leu Ala Gly Cys Glu Ser Ile Thr Leu Pro Leu Asp Val Ala Gln 
            180                 185                 190         


Gln Met Ile Ser Tyr Pro Ala Val Asp Ala Ala Val Ala Lys Phe Glu 
        195                 200                 205             


Gln Asp Trp Gln Gly Ala Phe Gly Arg Thr Ser Ile 
    210                 215                 220 


<210>  110
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Ec.FsaA

<400>  110
atggaactgt atctggatac ttcagacgtt gttgcggtga aggcgctgtc acgtattttt       60

ccgctggcgg gtgtgaccac taacccaagc attatcgccg cgggtaaaaa accgctggat      120

gttgtgcttc cgcaacttca tgaagcgatg ggcggtcagg ggcgtctgtt tgcccaggta      180

atggctacca ctgccgaagg gatggttaat gacgcgctta agctgcgttc tattattgcg      240

gatatcgtgg tgaaagttcc ggtgaccgcc gaggggctgg cagctattaa gatgttaaaa      300

gcggaaggga ttccgacgta tggaaccgcg gtatatggcg cagcacaagg gctgctgtcg      360

gcgctggcag gtgcggaata tgttggccct tacgttaatc gtattgatgc tcagggcggt      420

agcggcattc agactgtgac cgacttacac cagttattga aaatgcatgc gccgcaggcg      480

aaagtgctgg cagcgagttt caaaaccccg cgtcaggcgc tggactgctt actggcagga      540

tgtgaatcaa ttactctgcc actggatgtg gcacaacaga tgattagcta tccggcggtt      600

gatgccgctg tggcgaagtt tgagcaggac tggcagggag cgtttggcag aacgtcgatt      660

taa                                                                    663


<210>  111
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Ec.FsaA

<400>  111

Met Glu Leu Tyr Leu Asp Thr Ser Asp Val Val Ala Val Lys Ala Leu 
1               5                   10                  15      


Ser Arg Ile Phe Pro Leu Ala Gly Val Thr Thr Asn Pro Ser Ile Ile 
            20                  25                  30          


Ala Ala Gly Lys Lys Pro Leu Asp Val Val Leu Pro Gln Leu His Glu 
        35                  40                  45              


Ala Met Gly Gly Gln Gly Arg Leu Phe Ala Gln Val Met Ala Thr Thr 
    50                  55                  60                  


Ala Glu Gly Met Val Asn Asp Ala Leu Lys Leu Arg Ser Ile Ile Ala 
65                  70                  75                  80  


Asp Ile Val Val Lys Val Pro Val Thr Ala Glu Gly Leu Ala Ala Ile 
                85                  90                  95      


Lys Met Leu Lys Ala Glu Gly Ile Pro Thr Tyr Gly Thr Ala Val Tyr 
            100                 105                 110         


Gly Ala Ala Gln Gly Leu Leu Ser Ala Leu Ala Gly Ala Glu Tyr Val 
        115                 120                 125             


Gly Pro Tyr Val Asn Arg Ile Asp Ala Gln Gly Gly Ser Gly Ile Gln 
    130                 135                 140                 


Thr Val Thr Asp Leu His Gln Leu Leu Lys Met His Ala Pro Gln Ala 
145                 150                 155                 160 


Lys Val Leu Ala Ala Ser Phe Lys Thr Pro Arg Gln Ala Leu Asp Cys 
                165                 170                 175     


Leu Leu Ala Gly Cys Glu Ser Ile Thr Leu Pro Leu Asp Val Ala Gln 
            180                 185                 190         


Gln Met Ile Ser Tyr Pro Ala Val Asp Ala Ala Val Ala Lys Phe Glu 
        195                 200                 205             


Gln Asp Trp Gln Gly Ala Phe Gly Arg Thr Ser Ile 
    210                 215                 220 


<210>  112
<211>  1035
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  112
atgtcttctt cagtagcctc aaccgaaaac atagtcgaaa atatgttgca tccaaagact       60

acagaaatat acttttcact caacaatggt gttcgtatcc cagcactggg tttggggaca      120

gcaaatcctc acgaaaagtt agctgaaaca aaacaagccg taaaagctgc aatcaaagct      180

ggatacaggc acattgatac tgcttgggcc tacgagacag agccattcgt aggtgaagcc      240

atcaaggagt tattagaaga tggatctatc aaaagggagg atcttttcat aaccacaaaa      300

gtgtggccgg ttctatggga cgaagtggac agatcattga atgaatcttt gaaagcttta      360

ggcttggaat acgtcgactt gctcttgcaa cattggccgc tatgttttga aaagattaag      420

gaccctaagg ggatcagcgg actggtgaag actccggttg atgattctgg aaaaacaatg      480

tatgctgccg acggtgacta tttagaaact tacaagcaat tggaaaaaat ttaccttgat      540

cctaacgatc atcgtgtgag agccattggt gtctcaaatt tttccattga gtatttggaa      600

cgtctcatta aggaatgcag agttaagcca acggtgaacc aagtggaaac tcaccctcac      660

ttaccacaaa tggaactaag aaagttctgc tttatgcacg acattctgtt aacagcatac      720

tcaccattag gttcccatgg cgcaccaaac ttgaaaatcc cactagtgaa aaagcttgcc      780

gaaaagtaca atgtcacagg aaatgacttg ctaatttctt accatattag acaaggcact      840

atcgtaattc cgagatcctt gaatccagtt aggatttcct cgagtattga attcgcatct      900

ttgacaaagg atgaattaca agagttgaac gacttcggtg aaaaataccc agtgagattc      960

atcgatgagc catttgcagc catccttcca gagtttactg gtaacggacc aaacttggac     1020

aatttaaagt attaa                                                      1035


<210>  113
<211>  344
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  113

Met Ser Ser Ser Val Ala Ser Thr Glu Asn Ile Val Glu Asn Met Leu 
1               5                   10                  15      


His Pro Lys Thr Thr Glu Ile Tyr Phe Ser Leu Asn Asn Gly Val Arg 
            20                  25                  30          


Ile Pro Ala Leu Gly Leu Gly Thr Ala Asn Pro His Glu Lys Leu Ala 
        35                  40                  45              


Glu Thr Lys Gln Ala Val Lys Ala Ala Ile Lys Ala Gly Tyr Arg His 
    50                  55                  60                  


Ile Asp Thr Ala Trp Ala Tyr Glu Thr Glu Pro Phe Val Gly Glu Ala 
65                  70                  75                  80  


Ile Lys Glu Leu Leu Glu Asp Gly Ser Ile Lys Arg Glu Asp Leu Phe 
                85                  90                  95      


Ile Thr Thr Lys Val Trp Pro Val Leu Trp Asp Glu Val Asp Arg Ser 
            100                 105                 110         


Leu Asn Glu Ser Leu Lys Ala Leu Gly Leu Glu Tyr Val Asp Leu Leu 
        115                 120                 125             


Leu Gln His Trp Pro Leu Cys Phe Glu Lys Ile Lys Asp Pro Lys Gly 
    130                 135                 140                 


Ile Ser Gly Leu Val Lys Thr Pro Val Asp Asp Ser Gly Lys Thr Met 
145                 150                 155                 160 


Tyr Ala Ala Asp Gly Asp Tyr Leu Glu Thr Tyr Lys Gln Leu Glu Lys 
                165                 170                 175     


Ile Tyr Leu Asp Pro Asn Asp His Arg Val Arg Ala Ile Gly Val Ser 
            180                 185                 190         


Asn Phe Ser Ile Glu Tyr Leu Glu Arg Leu Ile Lys Glu Cys Arg Val 
        195                 200                 205             


Lys Pro Thr Val Asn Gln Val Glu Thr His Pro His Leu Pro Gln Met 
    210                 215                 220                 


Glu Leu Arg Lys Phe Cys Phe Met His Asp Ile Leu Leu Thr Ala Tyr 
225                 230                 235                 240 


Ser Pro Leu Gly Ser His Gly Ala Pro Asn Leu Lys Ile Pro Leu Val 
                245                 250                 255     


Lys Lys Leu Ala Glu Lys Tyr Asn Val Thr Gly Asn Asp Leu Leu Ile 
            260                 265                 270         


Ser Tyr His Ile Arg Gln Gly Thr Ile Val Ile Pro Arg Ser Leu Asn 
        275                 280                 285             


Pro Val Arg Ile Ser Ser Ser Ile Glu Phe Ala Ser Leu Thr Lys Asp 
    290                 295                 300                 


Glu Leu Gln Glu Leu Asn Asp Phe Gly Glu Lys Tyr Pro Val Arg Phe 
305                 310                 315                 320 


Ile Asp Glu Pro Phe Ala Ala Ile Leu Pro Glu Phe Thr Gly Asn Gly 
                325                 330                 335     


Pro Asn Leu Asp Asn Leu Lys Tyr 
            340                 


<210>  114
<211>  1008
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  114
atggttaatg aaaaagtgaa tccattcgac ttagcttcgg tttctccttt agtcttagga       60

ggtgcaatat tgaaccagca atatacagat gagccagaat ccattccact ggaagacata      120

atcaaatacg cattttcgca tggtatcaat gcaattgaca cttctcccta ctatggccct      180

agtgaggttc tttatggtag ggcactgtcc aatttaagga atgaatttcc cagagacact      240

tattttatat gcacaaaggt tgggcgtatt ggtgcggaag agtttaacta ttctagagat      300

ttcgtgagat ttagtgttca cagatcgtgc gaaagattac acactacata tctcgatttg      360

gtgtatttgc acgatgtcga gtttgtcaaa tttccagaca tcttagaggc attaaaggaa      420

ttgaggacct tgaagaacaa aggagttatc aaaaattttg gcatatcagg ctacccaatc      480

gactttatca cctggcttgc tgagtactgc tctaccgagg aaagtgatat tgggtcattg      540

gatgcagtat tgtcctattg taacttgaac ttacaaaaca ataagctatt gaactttcga      600

gaaagactgc tacgcaatgc taaactgaaa atggtttgca acgcatcaat cttgagcatg      660

tcgctactaa ggtcacagga gacaagacag tttcacccgt gttctcatga attgagagaa      720

tgcgcatctc aggctgccaa atactgtcaa gaacaaaatg tcgacttagc cgatttggcc      780

acaagatacg cgatttcgga atgggtagga aagggacccg ttgttcttgg agtcagtagc      840

atggaagaat tgaaacttgc tctggataat tacgaaatag tgaaatcgaa tggcaacaga      900

ttatcttcta aggacggaca actagtagaa tatatccaaa agaatatttt taaagaacat      960

tttaatgaag agtggtcttc aggtattcct catccagaaa tgatataa                  1008


<210>  115
<211>  335
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  115

Met Val Asn Glu Lys Val Asn Pro Phe Asp Leu Ala Ser Val Ser Pro 
1               5                   10                  15      


Leu Val Leu Gly Gly Ala Ile Leu Asn Gln Gln Tyr Thr Asp Glu Pro 
            20                  25                  30          


Glu Ser Ile Pro Leu Glu Asp Ile Ile Lys Tyr Ala Phe Ser His Gly 
        35                  40                  45              


Ile Asn Ala Ile Asp Thr Ser Pro Tyr Tyr Gly Pro Ser Glu Val Leu 
    50                  55                  60                  


Tyr Gly Arg Ala Leu Ser Asn Leu Arg Asn Glu Phe Pro Arg Asp Thr 
65                  70                  75                  80  


Tyr Phe Ile Cys Thr Lys Val Gly Arg Ile Gly Ala Glu Glu Phe Asn 
                85                  90                  95      


Tyr Ser Arg Asp Phe Val Arg Phe Ser Val His Arg Ser Cys Glu Arg 
            100                 105                 110         


Leu His Thr Thr Tyr Leu Asp Leu Val Tyr Leu His Asp Val Glu Phe 
        115                 120                 125             


Val Lys Phe Pro Asp Ile Leu Glu Ala Leu Lys Glu Leu Arg Thr Leu 
    130                 135                 140                 


Lys Asn Lys Gly Val Ile Lys Asn Phe Gly Ile Ser Gly Tyr Pro Ile 
145                 150                 155                 160 


Asp Phe Ile Thr Trp Leu Ala Glu Tyr Cys Ser Thr Glu Glu Ser Asp 
                165                 170                 175     


Ile Gly Ser Leu Asp Ala Val Leu Ser Tyr Cys Asn Leu Asn Leu Gln 
            180                 185                 190         


Asn Asn Lys Leu Leu Asn Phe Arg Glu Arg Leu Leu Arg Asn Ala Lys 
        195                 200                 205             


Leu Lys Met Val Cys Asn Ala Ser Ile Leu Ser Met Ser Leu Leu Arg 
    210                 215                 220                 


Ser Gln Glu Thr Arg Gln Phe His Pro Cys Ser His Glu Leu Arg Glu 
225                 230                 235                 240 


Cys Ala Ser Gln Ala Ala Lys Tyr Cys Gln Glu Gln Asn Val Asp Leu 
                245                 250                 255     


Ala Asp Leu Ala Thr Arg Tyr Ala Ile Ser Glu Trp Val Gly Lys Gly 
            260                 265                 270         


Pro Val Val Leu Gly Val Ser Ser Met Glu Glu Leu Lys Leu Ala Leu 
        275                 280                 285             


Asp Asn Tyr Glu Ile Val Lys Ser Asn Gly Asn Arg Leu Ser Ser Lys 
    290                 295                 300                 


Asp Gly Gln Leu Val Glu Tyr Ile Gln Lys Asn Ile Phe Lys Glu His 
305                 310                 315                 320 


Phe Asn Glu Glu Trp Ser Ser Gly Ile Pro His Pro Glu Met Ile 
                325                 330                 335 


<210>  116
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr Pc.TadH

<400>  116
atgtctaccg atagtttaca acagtttcgt cgccgtgtgg caattccggg tccggctggt       60

tttggtgcag caccgctggg caatctgttt agccgtgtta ccgatgaggc cgcacaagaa      120

actttaagtg ccgcatgggg tgctggtatc cgctactttg ataccgcacc gttctatggc      180

atgggtctga gtgaacgccg tctgggtcgc gcactggcca gctatccgcg tgatgccttc      240

gtgattagca ccaaagtggg tcgtttactg atcgccgacg acagtgtgcc ggaaacccag      300

cacggttatg ttggtggttt accgtaccgc gttgaatacg actatactgc cgatggcgcc      360

cgccgtagca ttgaaagctc tttagaacgt ttaggtttag atcgtattga cattgtgtat      420

attcacgacg tggccgagga tacccatggt ccgctgtggc gtcagcatta tcgtaccgcc      480

gctggtggtg caatgaaagc tttaagccgt ttacgcgatg aaggtgtgat tggtggctgg      540

ggtttaggcg tgaatcgtgt tgaaccgtgt ctgatggctt tagccgatgc cgatccggac      600

gtctttttaa tcgccggccg ctatacttta ctggatacca cagctttaga tgctttaatt      660

ccggcatgcg aagcacgcgg tgcacgttta gttgttggtg gtccgtacaa tagtggttta      720

ctggctggtg gcgatacctt tgaatatgcc cgcgcagatg ccgcaatgtt agcccgtcgc      780

gcacgtttat taagccactg cgaacgcttt ggtgttgatt taaaggccgc cgctttacag      840

ttttgtaaag ccccgggcgt tgttgcatgc gttattgccg gtgcccgcaa tgcagatgag      900

gttcgtcaga actgcgcagc aatgacagca ccggtgccgc gcgaattttg gcaagcttta      960

aaggaagagg gcttagttcc gcaaggtgca ccggttccgg cataa                     1005


<210>  117
<211>  334
<212>  PRT
<213>  Paraburkholderia caryophylli

<400>  117

Met Ser Thr Asp Ser Leu Gln Gln Phe Arg Arg Arg Val Ala Ile Pro 
1               5                   10                  15      


Gly Pro Ala Gly Phe Gly Ala Ala Pro Leu Gly Asn Leu Phe Ser Arg 
            20                  25                  30          


Val Thr Asp Glu Ala Ala Gln Glu Thr Leu Ser Ala Ala Trp Gly Ala 
        35                  40                  45              


Gly Ile Arg Tyr Phe Asp Thr Ala Pro Phe Tyr Gly Met Gly Leu Ser 
    50                  55                  60                  


Glu Arg Arg Leu Gly Arg Ala Leu Ala Ser Tyr Pro Arg Asp Ala Phe 
65                  70                  75                  80  


Val Ile Ser Thr Lys Val Gly Arg Leu Leu Ile Ala Asp Asp Ser Val 
                85                  90                  95      


Pro Glu Thr Gln His Gly Tyr Val Gly Gly Leu Pro Tyr Arg Val Glu 
            100                 105                 110         


Tyr Asp Tyr Thr Ala Asp Gly Ala Arg Arg Ser Ile Glu Ser Ser Leu 
        115                 120                 125             


Glu Arg Leu Gly Leu Asp Arg Ile Asp Ile Val Tyr Ile His Asp Val 
    130                 135                 140                 


Ala Glu Asp Thr His Gly Pro Leu Trp Arg Gln His Tyr Arg Thr Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Met Lys Ala Leu Ser Arg Leu Arg Asp Glu Gly Val 
                165                 170                 175     


Ile Gly Gly Trp Gly Leu Gly Val Asn Arg Val Glu Pro Cys Leu Met 
            180                 185                 190         


Ala Leu Ala Asp Ala Asp Pro Asp Val Phe Leu Ile Ala Gly Arg Tyr 
        195                 200                 205             


Thr Leu Leu Asp Thr Thr Ala Leu Asp Ala Leu Ile Pro Ala Cys Glu 
    210                 215                 220                 


Ala Arg Gly Ala Arg Leu Val Val Gly Gly Pro Tyr Asn Ser Gly Leu 
225                 230                 235                 240 


Leu Ala Gly Gly Asp Thr Phe Glu Tyr Ala Arg Ala Asp Ala Ala Met 
                245                 250                 255     


Leu Ala Arg Arg Ala Arg Leu Leu Ser His Cys Glu Arg Phe Gly Val 
            260                 265                 270         


Asp Leu Lys Ala Ala Ala Leu Gln Phe Cys Lys Ala Pro Gly Val Val 
        275                 280                 285             


Ala Cys Val Ile Ala Gly Ala Arg Asn Ala Asp Glu Val Arg Gln Asn 
    290                 295                 300                 


Cys Ala Ala Met Thr Ala Pro Val Pro Arg Glu Phe Trp Gln Ala Leu 
305                 310                 315                 320 


Lys Glu Glu Gly Leu Val Pro Gln Gly Ala Pro Val Pro Ala 
                325                 330                 


<210>  118
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr Pl.LgdA

<400>  118
atgagtaatg ccgaaaaagc actgggcgtg gctttaatcg gtaccggctt tatgggcaaa       60

tgccatgcca tggcatggcg caatgtggcc accgcatttg gtggtttacc gccgcgttta      120

gaggtgctgg cagatatgcc ggcagataag gcacattctt tagcaagcag ctttggcttt      180

gcccgcggta ccgcagattg gcgtgaagcc gttaatgatc cggcagtgga cgtggtgagc      240

attaccaccc cgaacggctt acatcgcgaa atggccgaag cagcactggc agctggtaaa      300

catgtttggc tggagaagcc gatggcttta agtgtggaag atgcccaagc tatggaagca      360

gccgcccgtg caagcgatcg tcgcaccatc atcggctaca actatactcg cagcccggcc      420

tttcgcgccg ccgtggatct gattgcagaa ggcgcaattg gccgtccgat tcactttcgc      480

ggcatgtatg acgaggacta catggccgat ccggatctgc cgtggagctg gcgtctgaca      540

cgtaaagatg gtggtttagg tgcactgggt gatctgggtt gccatctggt tagcgtgatg      600

gtgagcttaa tgggtccggt tgcacgcgtg tatgcacaag ctgataccgt gattaccgat      660

cgccctcatc aaggtggcac agcacgcgtt gaaaatgagg atcaagctca agctttaatc      720

cgcttcgcaa gcggtaccag cggtgaattt agctgcagcc gtgtggcccg cggttatcgt      780

tgccgtctgg catgggaagt gcaaggtacc gaaggtactt tacgctttga tcaagaacgc      840

atgaacgaac tgtggctgta tcagccgggt cgcccggaaa tcgatggctt tcgccgcatc      900

ttaactggtc cggcccagcc gggctttgca gcattttgcc cgggcggtgg ccataacttt      960

ggctttaatg agcagaaagt ggttgaagcc gaaatgctgc gccaagctat tgctggtcgc     1020

ggtaaagcat ggccggactt caccgatggt ctgaccattg aacgcgtgat tcacggtatg     1080

gcaaccagtg cccaaactgg tcagccggtg aatttttaa                            1119


<210>  119
<211>  372
<212>  PRT
<213>  Paracoccus laeviglucosivorans

<400>  119

Met Ser Asn Ala Glu Lys Ala Leu Gly Val Ala Leu Ile Gly Thr Gly 
1               5                   10                  15      


Phe Met Gly Lys Cys His Ala Met Ala Trp Arg Asn Val Ala Thr Ala 
            20                  25                  30          


Phe Gly Gly Leu Pro Pro Arg Leu Glu Val Leu Ala Asp Met Pro Ala 
        35                  40                  45              


Asp Lys Ala His Ser Leu Ala Ser Ser Phe Gly Phe Ala Arg Gly Thr 
    50                  55                  60                  


Ala Asp Trp Arg Glu Ala Val Asn Asp Pro Ala Val Asp Val Val Ser 
65                  70                  75                  80  


Ile Thr Thr Pro Asn Gly Leu His Arg Glu Met Ala Glu Ala Ala Leu 
                85                  90                  95      


Ala Ala Gly Lys His Val Trp Leu Glu Lys Pro Met Ala Leu Ser Val 
            100                 105                 110         


Glu Asp Ala Gln Ala Met Glu Ala Ala Ala Arg Ala Ser Asp Arg Arg 
        115                 120                 125             


Thr Ile Ile Gly Tyr Asn Tyr Thr Arg Ser Pro Ala Phe Arg Ala Ala 
    130                 135                 140                 


Val Asp Leu Ile Ala Glu Gly Ala Ile Gly Arg Pro Ile His Phe Arg 
145                 150                 155                 160 


Gly Met Tyr Asp Glu Asp Tyr Met Ala Asp Pro Asp Leu Pro Trp Ser 
                165                 170                 175     


Trp Arg Leu Thr Arg Lys Asp Gly Gly Leu Gly Ala Leu Gly Asp Leu 
            180                 185                 190         


Gly Cys His Leu Val Ser Val Met Val Ser Leu Met Gly Pro Val Ala 
        195                 200                 205             


Arg Val Tyr Ala Gln Ala Asp Thr Val Ile Thr Asp Arg Pro His Gln 
    210                 215                 220                 


Gly Gly Thr Ala Arg Val Glu Asn Glu Asp Gln Ala Gln Ala Leu Ile 
225                 230                 235                 240 


Arg Phe Ala Ser Gly Thr Ser Gly Glu Phe Ser Cys Ser Arg Val Ala 
                245                 250                 255     


Arg Gly Tyr Arg Cys Arg Leu Ala Trp Glu Val Gln Gly Thr Glu Gly 
            260                 265                 270         


Thr Leu Arg Phe Asp Gln Glu Arg Met Asn Glu Leu Trp Leu Tyr Gln 
        275                 280                 285             


Pro Gly Arg Pro Glu Ile Asp Gly Phe Arg Arg Ile Leu Thr Gly Pro 
    290                 295                 300                 


Ala Gln Pro Gly Phe Ala Ala Phe Cys Pro Gly Gly Gly His Asn Phe 
305                 310                 315                 320 


Gly Phe Asn Glu Gln Lys Val Val Glu Ala Glu Met Leu Arg Gln Ala 
                325                 330                 335     


Ile Ala Gly Arg Gly Lys Ala Trp Pro Asp Phe Thr Asp Gly Leu Thr 
            340                 345                 350         


Ile Glu Arg Val Ile His Gly Met Ala Thr Ser Ala Gln Thr Gly Gln 
        355                 360                 365             


Pro Val Asn Phe 
    370         


<210>  120
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr Ps.Fdh

<400>  120
atgtcttcta ctgaacctgc tgcagcagct gctggtctgg ccattccggc actgggttat       60

ggcgccgcaa acgtgggcaa tttatttcgt gcactgagcg acgatgaagc atgggccgtt      120

ctggaagcag cttgggatgc cggcattcgt tattatgaca ccgccccgca ttatggttta      180

ggtctgagcg aaaagcgtct gggtgcattt ttacagacca agccgcgcga cgaatttgtg      240

gttagcacca aagctggtcg tttattacgt cctaatccgg aacgccgtcc gagcggtctg      300

gataccgata acgactttca cgtgccggat gatctgcgcc gcgaatggga tttcaccgaa      360

caaggtattc gcgccagtat tgccgagagt caagaacgtc tgggtctgga tcgcattgat      420

ctgctgtatt tacatgatcc ggaacgtcat gatctggatc tggcactggc aagtgccttt      480

ccggctttag aaaaagtgcg cgccgaaggc gtggtgaaag ccattggcat tggcagcatg      540

gtgagtgatg cactgacccg cgccgttcgt gaagcagatt tagatttaat catggtggcc      600

ggtcgctata ctttattaga acagccggca gccaccgaag ttctgccggc ttgtgcagaa      660

aatgccaccg gcattgtggc cgccagtgtg tttaatagcg gtttactggc acagagtgag      720

ccgaaacgtg atggccgcta tgagtatggc cagctgccgg atgaactgtg ggatcgtctg      780

gtgcgcattg ccgccatttg tcgcaaccat gatgttccgc tgccggccgc agccatccag      840

tttccgctgc agagtgcttt agtgcgtagc gtggttgtgg gtggtagtcg cccggcacag      900

ctgacccaga atgcagagta tgccgcttta gaaattccgg ctggtttatg ggcagaactg      960

gcagaagccc gcttaattcc gaccccgtaa                                       990


<210>  121
<211>  329
<212>  PRT
<213>  Pseudomonas sp. 1143

<400>  121

Met Ser Ser Thr Glu Pro Ala Ala Ala Ala Ala Gly Leu Ala Ile Pro 
1               5                   10                  15      


Ala Leu Gly Tyr Gly Ala Ala Asn Val Gly Asn Leu Phe Arg Ala Leu 
            20                  25                  30          


Ser Asp Asp Glu Ala Trp Ala Val Leu Glu Ala Ala Trp Asp Ala Gly 
        35                  40                  45              


Ile Arg Tyr Tyr Asp Thr Ala Pro His Tyr Gly Leu Gly Leu Ser Glu 
    50                  55                  60                  


Lys Arg Leu Gly Ala Phe Leu Gln Thr Lys Pro Arg Asp Glu Phe Val 
65                  70                  75                  80  


Val Ser Thr Lys Ala Gly Arg Leu Leu Arg Pro Asn Pro Glu Arg Arg 
                85                  90                  95      


Pro Ser Gly Leu Asp Thr Asp Asn Asp Phe His Val Pro Asp Asp Leu 
            100                 105                 110         


Arg Arg Glu Trp Asp Phe Thr Glu Gln Gly Ile Arg Ala Ser Ile Ala 
        115                 120                 125             


Glu Ser Gln Glu Arg Leu Gly Leu Asp Arg Ile Asp Leu Leu Tyr Leu 
    130                 135                 140                 


His Asp Pro Glu Arg His Asp Leu Asp Leu Ala Leu Ala Ser Ala Phe 
145                 150                 155                 160 


Pro Ala Leu Glu Lys Val Arg Ala Glu Gly Val Val Lys Ala Ile Gly 
                165                 170                 175     


Ile Gly Ser Met Val Ser Asp Ala Leu Thr Arg Ala Val Arg Glu Ala 
            180                 185                 190         


Asp Leu Asp Leu Ile Met Val Ala Gly Arg Tyr Thr Leu Leu Glu Gln 
        195                 200                 205             


Pro Ala Ala Thr Glu Val Leu Pro Ala Cys Ala Glu Asn Ala Thr Gly 
    210                 215                 220                 


Ile Val Ala Ala Ser Val Phe Asn Ser Gly Leu Leu Ala Gln Ser Glu 
225                 230                 235                 240 


Pro Lys Arg Asp Gly Arg Tyr Glu Tyr Gly Gln Leu Pro Asp Glu Leu 
                245                 250                 255     


Trp Asp Arg Leu Val Arg Ile Ala Ala Ile Cys Arg Asn His Asp Val 
            260                 265                 270         


Pro Leu Pro Ala Ala Ala Ile Gln Phe Pro Leu Gln Ser Ala Leu Val 
        275                 280                 285             


Arg Ser Val Val Val Gly Gly Ser Arg Pro Ala Gln Leu Thr Gln Asn 
    290                 295                 300                 


Ala Glu Tyr Ala Ala Leu Glu Ile Pro Ala Gly Leu Trp Ala Glu Leu 
305                 310                 315                 320 


Ala Glu Ala Arg Leu Ile Pro Thr Pro 
                325                 


<210>  122
<211>  1149
<212>  DNA
<213>  Xanthomonas campestris

<400>  122
atgaatacac gtcgccaatt cctgtctgct gccgcggccg gcaccacggc gctggccgca       60

tcgccattgc tggcacagtc gtccgcaccc ggaagcgtga tgcccacgcg cggccgcacg      120

gcggcctctg ccgtgcaaac tagcgcgccg gccaagggcg cacgttatcg gccgaccacg      180

cggttgggct ttggcggtgt tgcaatcggc aatgggtttg cgccagccac cgatgcgcaa      240

agcgagcaga cgctggcggc ggtgtgggcc tcgggcgtgc gctatttcga tacctcgccg      300

tggtacgggc tgggcctgtc cgaacgccgc accggccatc atctgcataa ccatgccgcc      360

gatagctacg tgctctcgac caaggtgggg cgcttgctga ccgcgaccga caagccgccg      420

aagaccatgt ggcagcaacc gtccccgttc gattaccgct acgactacag cgccgccggc      480

gtgcgccgct cgatcgaaga cagcctgcaa cggctgggcg tgtcgcagat cgacatcgtg      540

tacatccacg acctctcgcc ggagaacgaa aaagacctcg gcatgccctg ggaacagcgc      600

tttgccgagg ccgccaaggg cgcgatgccg gagctgacca agatgcgcaa ggagggcctg      660

atcaaggcct ggggctttgg cgtcaatcgc ccggaaccgg ccttgcgtgc gattgaagaa      720

gccgacccgg atatcttctt gctggcctgc cagtactcgt tgctcgacca cgcgcaggcc      780

ttgcatgaca ccttcccgaa gatcgccaga cacggcgcct cggtggtggt gggcgcgccg      840

ctgctggccg gttatctggc cgggcgcgac cgttatctgt acgagggcac ggtgccggag      900

tgggcgccgg gcaaacgcca gaaggccctg gcaatctgcg acaaacacgg cgtggatctg      960

cgtacggtgt cgctgcaatt tgctgccgca ccggaggtgg tgtcggcggt gattcccggc     1020

gcacgcacgg ccgaacaggc gcaggccaat gcggcctcga tgcgggtggc gattcctgcc     1080

gcgctctggg acgacctcaa gcgcgcgcag gtgatcgaag cggatgcgcc ggtgccggcg     1140

gctggatga                                                             1149


<210>  123
<211>  382
<212>  PRT
<213>  Xanthomonas campestris

<400>  123

Met Asn Thr Arg Arg Gln Phe Leu Ser Ala Ala Ala Ala Gly Thr Thr 
1               5                   10                  15      


Ala Leu Ala Ala Ser Pro Leu Leu Ala Gln Ser Ser Ala Pro Gly Ser 
            20                  25                  30          


Val Met Pro Thr Arg Gly Arg Thr Ala Ala Ser Ala Val Gln Thr Ser 
        35                  40                  45              


Ala Pro Ala Lys Gly Ala Arg Tyr Arg Pro Thr Thr Arg Leu Gly Phe 
    50                  55                  60                  


Gly Gly Val Ala Ile Gly Asn Gly Phe Ala Pro Ala Thr Asp Ala Gln 
65                  70                  75                  80  


Ser Glu Gln Thr Leu Ala Ala Val Trp Ala Ser Gly Val Arg Tyr Phe 
                85                  90                  95      


Asp Thr Ser Pro Trp Tyr Gly Leu Gly Leu Ser Glu Arg Arg Thr Gly 
            100                 105                 110         


His His Leu His Asn His Ala Ala Asp Ser Tyr Val Leu Ser Thr Lys 
        115                 120                 125             


Val Gly Arg Leu Leu Thr Ala Thr Asp Lys Pro Pro Lys Thr Met Trp 
    130                 135                 140                 


Gln Gln Pro Ser Pro Phe Asp Tyr Arg Tyr Asp Tyr Ser Ala Ala Gly 
145                 150                 155                 160 


Val Arg Arg Ser Ile Glu Asp Ser Leu Gln Arg Leu Gly Val Ser Gln 
                165                 170                 175     


Ile Asp Ile Val Tyr Ile His Asp Leu Ser Pro Glu Asn Glu Lys Asp 
            180                 185                 190         


Leu Gly Met Pro Trp Glu Gln Arg Phe Ala Glu Ala Ala Lys Gly Ala 
        195                 200                 205             


Met Pro Glu Leu Thr Lys Met Arg Lys Glu Gly Leu Ile Lys Ala Trp 
    210                 215                 220                 


Gly Phe Gly Val Asn Arg Pro Glu Pro Ala Leu Arg Ala Ile Glu Glu 
225                 230                 235                 240 


Ala Asp Pro Asp Ile Phe Leu Leu Ala Cys Gln Tyr Ser Leu Leu Asp 
                245                 250                 255     


His Ala Gln Ala Leu His Asp Thr Phe Pro Lys Ile Ala Arg His Gly 
            260                 265                 270         


Ala Ser Val Val Val Gly Ala Pro Leu Leu Ala Gly Tyr Leu Ala Gly 
        275                 280                 285             


Arg Asp Arg Tyr Leu Tyr Glu Gly Thr Val Pro Glu Trp Ala Pro Gly 
    290                 295                 300                 


Lys Arg Gln Lys Ala Leu Ala Ile Cys Asp Lys His Gly Val Asp Leu 
305                 310                 315                 320 


Arg Thr Val Ser Leu Gln Phe Ala Ala Ala Pro Glu Val Val Ser Ala 
                325                 330                 335     


Val Ile Pro Gly Ala Arg Thr Ala Glu Gln Ala Gln Ala Asn Ala Ala 
            340                 345                 350         


Ser Met Arg Val Ala Ile Pro Ala Ala Leu Trp Asp Asp Leu Lys Arg 
        355                 360                 365             


Ala Gln Val Ile Glu Ala Asp Ala Pro Val Pro Ala Ala Gly 
    370                 375                 380         


<210>  124
<211>  1014
<212>  DNA
<213>  Acidovorax avenae

<400>  124
atgaaggtca cagaaacacg ccgcatcggc gaaggccccg cacggctcac gcgcttcggc       60

gtgggttgcg gcacgctggc cgggctgtac aagcccacgt ccgaggcaga cgcccgggcc      120

acgctgcagg cggcatggga tgccggcctg cgctacttcg acaccgcccc tttctacggg      180

cacacgctga gcgagcaccg cgtgggcgcc ttcctgcgcg agcagccccg cgatgccttc      240

gtcatcagca ccaaggtcgg ccggctgatg cgccccgatt cctccgtgca gccgatggac      300

aacggctggg ccgccccgct gccgttccgc ccggactacg actacagcta cggcggcgtc      360

atgcgctcgt tcgaggacag cctgcagcgg ctcggcctgc agcgcatcga cctgctgttc      420

gtgcacgaca tcggcaccta cacccatggc gaccggaacg ccgggcactg gaaggccctc      480

acggcacaag gcggcttccg cgcgctggaa gagctccggg ccgatggccg catcgccggc      540

ttcggcctgg gcgtcaacga agcccaagtc atcctcgaca gcctgcagga gacgcggctg      600

gactgctccc tgctcgccgg gcgctacacg ctgctggagc agcatagcct gccgctcatg      660

aacacatgcc agcggctcgg cagtgccatc gtcatcggcg gtccgttcaa ctccgggctg      720

ctggtgggca acggcaagtt cgactatgcg gatgcgccgg cggacatgct ggcgcgtgcc      780

caggcgctgg acgaggcgtg cgccgcgcac ggcgtggccc tgccagcggc cgcgctgcaa      840

tttccgatgg cccatggcgc cgtggcatcg tgcgtctccg gcgcgcgcaa cccggcccag      900

ctggaccaga ccgtgggctg gttcgagcag gacattcccg cagcgctctg ggccgacctg      960

cagcagcaag gcctgatcgc ggaaggctgc cccgttcccg gagccgcgcc atga           1014


<210>  125
<211>  337
<212>  PRT
<213>  Acidovorax avenae

<400>  125

Met Lys Val Thr Glu Thr Arg Arg Ile Gly Glu Gly Pro Ala Arg Leu 
1               5                   10                  15      


Thr Arg Phe Gly Val Gly Cys Gly Thr Leu Ala Gly Leu Tyr Lys Pro 
            20                  25                  30          


Thr Ser Glu Ala Asp Ala Arg Ala Thr Leu Gln Ala Ala Trp Asp Ala 
        35                  40                  45              


Gly Leu Arg Tyr Phe Asp Thr Ala Pro Phe Tyr Gly His Thr Leu Ser 
    50                  55                  60                  


Glu His Arg Val Gly Ala Phe Leu Arg Glu Gln Pro Arg Asp Ala Phe 
65                  70                  75                  80  


Val Ile Ser Thr Lys Val Gly Arg Leu Met Arg Pro Asp Ser Ser Val 
                85                  90                  95      


Gln Pro Met Asp Asn Gly Trp Ala Ala Pro Leu Pro Phe Arg Pro Asp 
            100                 105                 110         


Tyr Asp Tyr Ser Tyr Gly Gly Val Met Arg Ser Phe Glu Asp Ser Leu 
        115                 120                 125             


Gln Arg Leu Gly Leu Gln Arg Ile Asp Leu Leu Phe Val His Asp Ile 
    130                 135                 140                 


Gly Thr Tyr Thr His Gly Asp Arg Asn Ala Gly His Trp Lys Ala Leu 
145                 150                 155                 160 


Thr Ala Gln Gly Gly Phe Arg Ala Leu Glu Glu Leu Arg Ala Asp Gly 
                165                 170                 175     


Arg Ile Ala Gly Phe Gly Leu Gly Val Asn Glu Ala Gln Val Ile Leu 
            180                 185                 190         


Asp Ser Leu Gln Glu Thr Arg Leu Asp Cys Ser Leu Leu Ala Gly Arg 
        195                 200                 205             


Tyr Thr Leu Leu Glu Gln His Ser Leu Pro Leu Met Asn Thr Cys Gln 
    210                 215                 220                 


Arg Leu Gly Ser Ala Ile Val Ile Gly Gly Pro Phe Asn Ser Gly Leu 
225                 230                 235                 240 


Leu Val Gly Asn Gly Lys Phe Asp Tyr Ala Asp Ala Pro Ala Asp Met 
                245                 250                 255     


Leu Ala Arg Ala Gln Ala Leu Asp Glu Ala Cys Ala Ala His Gly Val 
            260                 265                 270         


Ala Leu Pro Ala Ala Ala Leu Gln Phe Pro Met Ala His Gly Ala Val 
        275                 280                 285             


Ala Ser Cys Val Ser Gly Ala Arg Asn Pro Ala Gln Leu Asp Gln Thr 
    290                 295                 300                 


Val Gly Trp Phe Glu Gln Asp Ile Pro Ala Ala Leu Trp Ala Asp Leu 
305                 310                 315                 320 


Gln Gln Gln Gly Leu Ile Ala Glu Gly Cys Pro Val Pro Gly Ala Ala 
                325                 330                 335     


Pro 
    


<210>  126
<211>  1086
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr Ppi.TadH

<400>  126
atgaatcggc gcacaggcgc ggcgagcgag acctatatca acgttgcgag gcaatccgtg       60

aacaacaggc aagccctgat tccgccggga ccgttgggtt tcggcgcggc ccccttgggc      120

aacctctttg cgcgcgtcag cgaagaagcg gctgaagaga cattgagcgc ggcatgggaa      180

gccggcatgc gctatttcga taccgcgccg ttctacggca tgggtctgtc cgaacagcgc      240

ctcggccgcg cgctcgcgca ccgtgcgcgc gacgaattcg tcgtctcgac gaaagtgggc      300

cgcctgctga ttcccgatgc gtccgttccc gaagtccagc acggctatgt cggcgcgctg      360

ccgtttcgcg tcgaattcga ttattcggcg caaggcgtgc tccgctccat cgacgagagt      420

ctcaagcgtc tttcactcga tcgcatcgat atcgtctata tccacgacgt cgccgaagat      480

gcgcatcgtg aggactggct gcggcaatac cgtatcgccg tcgaaggcgc gatgcgggcg      540

ctgagcgatc tgcgcgatca gggcgtgatc ggcgcatggg ggctcggcgt caaccgggtc      600

gagccgtgca tgatgacgtt gaacgacgcg gaccctgacg tgtttctgat cgccggaaga      660

tacacgctgc tcgacacgtc ggcgctcgat gcgctgatcc cggcttgcga tgctcgcggc      720

gtgcagttgg tcgcgggcgg tccgttcaac tcggggctgc tcgtgggcgg cacgacgttc      780

gaatatgccg aggcgccggc ggaaatgctc gagaagcggc gcagacttct cgcgcactgc      840

gagcgcttcg gcgtggacct gaaggcggcc gcgctgcagt tcacggatgc gccgcgagcg      900

gtcgcgtgcg tgatcgcggg cgcgagaaac gcgagcgaga tcagacagaa ctgcgcggca      960

atgaccgagc cgattccggc ggcattctgg gcggcattga aggccgatgg cctgattccc     1020

gccgatgcgc cggagcccct tgcttcaggc ggcgcgctcc acgcgacgac acacgagccc     1080

gtttag                                                                1086


<210>  127
<211>  361
<212>  PRT
<213>  Paraburkholderia piptadeniae

<400>  127

Met Asn Arg Arg Thr Gly Ala Ala Ser Glu Thr Tyr Ile Asn Val Ala 
1               5                   10                  15      


Arg Gln Ser Val Asn Asn Arg Gln Ala Leu Ile Pro Pro Gly Pro Leu 
            20                  25                  30          


Gly Phe Gly Ala Ala Pro Leu Gly Asn Leu Phe Ala Arg Val Ser Glu 
        35                  40                  45              


Glu Ala Ala Glu Glu Thr Leu Ser Ala Ala Trp Glu Ala Gly Met Arg 
    50                  55                  60                  


Tyr Phe Asp Thr Ala Pro Phe Tyr Gly Met Gly Leu Ser Glu Gln Arg 
65                  70                  75                  80  


Leu Gly Arg Ala Leu Ala His Arg Ala Arg Asp Glu Phe Val Val Ser 
                85                  90                  95      


Thr Lys Val Gly Arg Leu Leu Ile Pro Asp Ala Ser Val Pro Glu Val 
            100                 105                 110         


Gln His Gly Tyr Val Gly Ala Leu Pro Phe Arg Val Glu Phe Asp Tyr 
        115                 120                 125             


Ser Ala Gln Gly Val Leu Arg Ser Ile Asp Glu Ser Leu Lys Arg Leu 
    130                 135                 140                 


Ser Leu Asp Arg Ile Asp Ile Val Tyr Ile His Asp Val Ala Glu Asp 
145                 150                 155                 160 


Ala His Arg Glu Asp Trp Leu Arg Gln Tyr Arg Ile Ala Val Glu Gly 
                165                 170                 175     


Ala Met Arg Ala Leu Ser Asp Leu Arg Asp Gln Gly Val Ile Gly Ala 
            180                 185                 190         


Trp Gly Leu Gly Val Asn Arg Val Glu Pro Cys Met Met Thr Leu Asn 
        195                 200                 205             


Asp Ala Asp Pro Asp Val Phe Leu Ile Ala Gly Arg Tyr Thr Leu Leu 
    210                 215                 220                 


Asp Thr Ser Ala Leu Asp Ala Leu Ile Pro Ala Cys Asp Ala Arg Gly 
225                 230                 235                 240 


Val Gln Leu Val Ala Gly Gly Pro Phe Asn Ser Gly Leu Leu Val Gly 
                245                 250                 255     


Gly Thr Thr Phe Glu Tyr Ala Glu Ala Pro Ala Glu Met Leu Glu Lys 
            260                 265                 270         


Arg Arg Arg Leu Leu Ala His Cys Glu Arg Phe Gly Val Asp Leu Lys 
        275                 280                 285             


Ala Ala Ala Leu Gln Phe Thr Asp Ala Pro Arg Ala Val Ala Cys Val 
    290                 295                 300                 


Ile Ala Gly Ala Arg Asn Ala Ser Glu Ile Arg Gln Asn Cys Ala Ala 
305                 310                 315                 320 


Met Thr Glu Pro Ile Pro Ala Ala Phe Trp Ala Ala Leu Lys Ala Asp 
                325                 330                 335     


Gly Leu Ile Pro Ala Asp Ala Pro Glu Pro Leu Ala Ser Gly Gly Ala 
            340                 345                 350         


Leu His Ala Thr Thr His Glu Pro Val 
        355                 360     


<210>  128
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr Ss.Adh4

<400>  128
atggagaacg tgaatatggt gaaaagcaag gccgctttac tgaagaaatt cagcgaaccg       60

ctgagcatcg aggatgtgaa cattcccgaa ccgcaaggtg aagaagtgct gatccgcatt      120

ggtggtgctg gtgtgtgccg caccgatctg cgtgtgtgga agggcgtgga agccaaacaa      180

ggtttccgtt taccgatcat tctgggccat gaaaacgccg gcacaatcgt tgaagtgggc      240

gagctggcaa aagtgaagaa gggcgataac gtggtggtgt acgcaacttg gggcgattta      300

acttgtcgct attgccgcga gggtaaattt aatatttgta aaaaccaaat tatcccgggc      360

cagaccacca acggtggctt tagcgagtac atgctggtga aaagtagccg ctggctggtg      420

aaactgaaca gtctgagccc cgttgaagcc gcacctctgg ccgatgccgg tacaaccagc      480

atgggcgcca tccgtcaagc actgccgttc attagcaagt tcgccgaacc ggttgtgatt      540

gtgaatggta tcggcggttt agccgtgtac accattcaga ttctgaaggc tttaatgaaa      600

aacattacca tcgtgggtat cagccgcagc aaaaagcatc gcgacttcgc tttagaactg      660

ggcgccgatt acgtgagcga aatgaaggat gccgaatctt taatcaataa gctgaccgac      720

ggtttaggtg caagcatcgc aatcgatctg gtgggtaccg aagagaccac ctacaattta      780

ggcaagctgc tggcccaaga aggtgccatt attttagtgg gtatggaagg caaacgcgtg      840

agtctggaag ccttcgacac agcagtgtgg aacaagaaac tgctgggcag caactacggc      900

tctttaaatg atttagaaga tgtggtgcgt ctgagcgaaa gcggcaaaat taagccgtac      960

atcatcaagg tgccgctgga tgacatcaac aaagccttca ccaatctgga tgagggccgt     1020

gtggatggtc gccaagttat caccccgtaa                                      1050


<210>  129
<211>  349
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  129

Met Glu Asn Val Asn Met Val Lys Ser Lys Ala Ala Leu Leu Lys Lys 
1               5                   10                  15      


Phe Ser Glu Pro Leu Ser Ile Glu Asp Val Asn Ile Pro Glu Pro Gln 
            20                  25                  30          


Gly Glu Glu Val Leu Ile Arg Ile Gly Gly Ala Gly Val Cys Arg Thr 
        35                  40                  45              


Asp Leu Arg Val Trp Lys Gly Val Glu Ala Lys Gln Gly Phe Arg Leu 
    50                  55                  60                  


Pro Ile Ile Leu Gly His Glu Asn Ala Gly Thr Ile Val Glu Val Gly 
65                  70                  75                  80  


Glu Leu Ala Lys Val Lys Lys Gly Asp Asn Val Val Val Tyr Ala Thr 
                85                  90                  95      


Trp Gly Asp Leu Thr Cys Arg Tyr Cys Arg Glu Gly Lys Phe Asn Ile 
            100                 105                 110         


Cys Lys Asn Gln Ile Ile Pro Gly Gln Thr Thr Asn Gly Gly Phe Ser 
        115                 120                 125             


Glu Tyr Met Leu Val Lys Ser Ser Arg Trp Leu Val Lys Leu Asn Ser 
    130                 135                 140                 


Leu Ser Pro Val Glu Ala Ala Pro Leu Ala Asp Ala Gly Thr Thr Ser 
145                 150                 155                 160 


Met Gly Ala Ile Arg Gln Ala Leu Pro Phe Ile Ser Lys Phe Ala Glu 
                165                 170                 175     


Pro Val Val Ile Val Asn Gly Ile Gly Gly Leu Ala Val Tyr Thr Ile 
            180                 185                 190         


Gln Ile Leu Lys Ala Leu Met Lys Asn Ile Thr Ile Val Gly Ile Ser 
        195                 200                 205             


Arg Ser Lys Lys His Arg Asp Phe Ala Leu Glu Leu Gly Ala Asp Tyr 
    210                 215                 220                 


Val Ser Glu Met Lys Asp Ala Glu Ser Leu Ile Asn Lys Leu Thr Asp 
225                 230                 235                 240 


Gly Leu Gly Ala Ser Ile Ala Ile Asp Leu Val Gly Thr Glu Glu Thr 
                245                 250                 255     


Thr Tyr Asn Leu Gly Lys Leu Leu Ala Gln Glu Gly Ala Ile Ile Leu 
            260                 265                 270         


Val Gly Met Glu Gly Lys Arg Val Ser Leu Glu Ala Phe Asp Thr Ala 
        275                 280                 285             


Val Trp Asn Lys Lys Leu Leu Gly Ser Asn Tyr Gly Ser Leu Asn Asp 
    290                 295                 300                 


Leu Glu Asp Val Val Arg Leu Ser Glu Ser Gly Lys Ile Lys Pro Tyr 
305                 310                 315                 320 


Ile Ile Lys Val Pro Leu Asp Asp Ile Asn Lys Ala Phe Thr Asn Leu 
                325                 330                 335     


Asp Glu Gly Arg Val Asp Gly Arg Gln Val Ile Thr Pro 
            340                 345                 


<210>  130
<211>  777
<212>  DNA
<213>  Burkholderia multivorans

<400>  130
atggatctga atctgcagga caaggtcgtg atcgtgacgg gcggcgcgtc gggcatcggc       60

ggcgcgatct cgatgcggct cgccgaagaa cgcgcgattc cggtcgtgtt cgcgcgccac      120

gcgcccgacg gcgcgttcct cgacgcgctc gcgcaacggc agccgcgcgc gacgtatctg      180

ccggtcgagc tgcaggacga tgcgcaatgc cgcgacgcgg tcgctcagac gatcgcgacg      240

ttcggacgcc tcgacgggct cgtgaacaac gcgggcgtca acgacggcat cgggctcgac      300

gcagggcgcg acgcgttcgt cgcatcgctc gagcgcaacc tgatccacta ctacgcgatg      360

gcgcattact gcgtgccgca tctgaaggcg acgcgcggcg cgatcgtcaa catctcgtcg      420

aagacggccg tgaccgggca gggcaatacg agcggctatt gcgcgtcgaa gggcgcgcag      480

ctcgcgctga cgcgcgaatg ggcggtcgcg ctgcgcgagc acggcgtgcg cgtgaacgcc      540

gtgattccgg ccgaggtcat gacgccgctc taccggaact ggatcgcgac gttcgaggat      600

cccgaggcga agctcgccga gatcgcggcg aaggtgccgc tcggcaagcg cttcacgaca      660

cccgacgaga tcgccgatac ggccgtgttc ctgctgtcgc cgcgcgcgtc gcacacgacg      720

ggcgaatggc tgttcgtcga cggcggctat acgcatctcg atcgtgcgct cgtctga         777


<210>  131
<211>  258
<212>  PRT
<213>  Burkholderia multivorans

<400>  131

Met Asp Leu Asn Leu Gln Asp Lys Val Val Ile Val Thr Gly Gly Ala 
1               5                   10                  15      


Ser Gly Ile Gly Gly Ala Ile Ser Met Arg Leu Ala Glu Glu Arg Ala 
            20                  25                  30          


Ile Pro Val Val Phe Ala Arg His Ala Pro Asp Gly Ala Phe Leu Asp 
        35                  40                  45              


Ala Leu Ala Gln Arg Gln Pro Arg Ala Thr Tyr Leu Pro Val Glu Leu 
    50                  55                  60                  


Gln Asp Asp Ala Gln Cys Arg Asp Ala Val Ala Gln Thr Ile Ala Thr 
65                  70                  75                  80  


Phe Gly Arg Leu Asp Gly Leu Val Asn Asn Ala Gly Val Asn Asp Gly 
                85                  90                  95      


Ile Gly Leu Asp Ala Gly Arg Asp Ala Phe Val Ala Ser Leu Glu Arg 
            100                 105                 110         


Asn Leu Ile His Tyr Tyr Ala Met Ala His Tyr Cys Val Pro His Leu 
        115                 120                 125             


Lys Ala Thr Arg Gly Ala Ile Val Asn Ile Ser Ser Lys Thr Ala Val 
    130                 135                 140                 


Thr Gly Gln Gly Asn Thr Ser Gly Tyr Cys Ala Ser Lys Gly Ala Gln 
145                 150                 155                 160 


Leu Ala Leu Thr Arg Glu Trp Ala Val Ala Leu Arg Glu His Gly Val 
                165                 170                 175     


Arg Val Asn Ala Val Ile Pro Ala Glu Val Met Thr Pro Leu Tyr Arg 
            180                 185                 190         


Asn Trp Ile Ala Thr Phe Glu Asp Pro Glu Ala Lys Leu Ala Glu Ile 
        195                 200                 205             


Ala Ala Lys Val Pro Leu Gly Lys Arg Phe Thr Thr Pro Asp Glu Ile 
    210                 215                 220                 


Ala Asp Thr Ala Val Phe Leu Leu Ser Pro Arg Ala Ser His Thr Thr 
225                 230                 235                 240 


Gly Glu Trp Leu Phe Val Asp Gly Gly Tyr Thr His Leu Asp Arg Ala 
                245                 250                 255     


Leu Val 
        


<210>  132
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr Tt.lac11

<400>  132
atgcgcaaac tgcttggcag ctctgccatc cacgtgctgt cccgtcgcac cggttatggt       60

atgtacttcc tgattctggc cctgggtgtc gctacacagg ttgtctttgg agcagaaccg      120

agtcagaatc cgagcgaaaa ggtggcatgg attgaacgcg cagatcccgg cctcgacgat      180

ctgattgctc cagatgcgca agtggaagtg ctggcagaag gttttgagtg gagcgaaggt      240

ccggtatgga ttcccgaagg cggctacttg ctgtttagcg atgttccgaa gaacaccatt      300

taccgctgga aagaaggtca ggggattgac atcttcctga aaccgtcggg atataccggc      360

tttcgtgaac gtggtggtga atcgggctca aacggcttag ccctggatcg ccaaggccgc      420

cttctgttgt gtcagcatgg tgatcgtcgt gtagctcgtt gggagaaagg ttgctttatc      480

acactggcag accagtatga gggcaaaccg ctgaattccc cgaatgactt ggtagtcaag      540

tcgaacggcg atatctactt cacggatcca ccatatggca tgactcctga ggcccaacgc      600

gatcccaatg cgctcggctt ttgcggcgtt tatcgcatta gtgcggatgg gaagctgacg      660

ctgttagttc gtgacatgac tcgccctaac gggatcgcct tcagcccaga cgagaaaacg      720

ctctatgttg cccagtcaga tccgcaacgc ccgttatgga tggcgttccc ggttcgcgaa      780

gatgggacct taggggaagg caaagtgttc ttcgatgcga aaccgtggca gcaaagtggc      840

ttgccgggac tcccagatgg catgaaagtg gaccagaaag gcaatctgtt tgcgactggt      900

ccgggtggtg tcaacatctt tcgccctgat ggtacctttc tgggccggat tcgggtgaaa      960

gtccctaccg ctaactgtgc gtttggtgat gacggatcta cgctttacat taccgcggac     1020

atgtatctgc ttcgtgtgaa aacgaaaacc aaaggactgg ggttctaa                  1068


<210>  133
<211>  355
<212>  PRT
<213>  Thermogutta terrifontis

<400>  133

Met Arg Lys Leu Leu Gly Ser Ser Ala Ile His Val Leu Ser Arg Arg 
1               5                   10                  15      


Thr Gly Tyr Gly Met Tyr Phe Leu Ile Leu Ala Leu Gly Val Ala Thr 
            20                  25                  30          


Gln Val Val Phe Gly Ala Glu Pro Ser Gln Asn Pro Ser Glu Lys Val 
        35                  40                  45              


Ala Trp Ile Glu Arg Ala Asp Pro Gly Leu Asp Asp Leu Ile Ala Pro 
    50                  55                  60                  


Asp Ala Gln Val Glu Val Leu Ala Glu Gly Phe Glu Trp Ser Glu Gly 
65                  70                  75                  80  


Pro Val Trp Ile Pro Glu Gly Gly Tyr Leu Leu Phe Ser Asp Val Pro 
                85                  90                  95      


Lys Asn Thr Ile Tyr Arg Trp Lys Glu Gly Gln Gly Ile Asp Ile Phe 
            100                 105                 110         


Leu Lys Pro Ser Gly Tyr Thr Gly Phe Arg Glu Arg Gly Gly Glu Ser 
        115                 120                 125             


Gly Ser Asn Gly Leu Ala Leu Asp Arg Gln Gly Arg Leu Leu Leu Cys 
    130                 135                 140                 


Gln His Gly Asp Arg Arg Val Ala Arg Trp Glu Lys Gly Cys Phe Ile 
145                 150                 155                 160 


Thr Leu Ala Asp Gln Tyr Glu Gly Lys Pro Leu Asn Ser Pro Asn Asp 
                165                 170                 175     


Leu Val Val Lys Ser Asn Gly Asp Ile Tyr Phe Thr Asp Pro Pro Tyr 
            180                 185                 190         


Gly Met Thr Pro Glu Ala Gln Arg Asp Pro Asn Ala Leu Gly Phe Cys 
        195                 200                 205             


Gly Val Tyr Arg Ile Ser Ala Asp Gly Lys Leu Thr Leu Leu Val Arg 
    210                 215                 220                 


Asp Met Thr Arg Pro Asn Gly Ile Ala Phe Ser Pro Asp Glu Lys Thr 
225                 230                 235                 240 


Leu Tyr Val Ala Gln Ser Asp Pro Gln Arg Pro Leu Trp Met Ala Phe 
                245                 250                 255     


Pro Val Arg Glu Asp Gly Thr Leu Gly Glu Gly Lys Val Phe Phe Asp 
            260                 265                 270         


Ala Lys Pro Trp Gln Gln Ser Gly Leu Pro Gly Leu Pro Asp Gly Met 
        275                 280                 285             


Lys Val Asp Gln Lys Gly Asn Leu Phe Ala Thr Gly Pro Gly Gly Val 
    290                 295                 300                 


Asn Ile Phe Arg Pro Asp Gly Thr Phe Leu Gly Arg Ile Arg Val Lys 
305                 310                 315                 320 


Val Pro Thr Ala Asn Cys Ala Phe Gly Asp Asp Gly Ser Thr Leu Tyr 
                325                 330                 335     


Ile Thr Ala Asp Met Tyr Leu Leu Arg Val Lys Thr Lys Thr Lys Gly 
            340                 345                 350         


Leu Gly Phe 
        355 


<210>  134
<211>  957
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr verkrzte Variante von Tt.lac11

<400>  134
atggaaccga gtcagaatcc gagcgaaaag gtggcatgga ttgaacgcgc agatcccggc       60

ctcgacgatc tgattgctcc agatgcgcaa gtggaagtgc tggcagaagg ttttgagtgg      120

agcgaaggtc cggtatggat tcccgaaggc ggctacttgc tgtttagcga tgttccgaag      180

aacaccattt accgctggaa agaaggtcag gggattgaca tcttcctgaa accgtcggga      240

tataccggct ttcgtgaacg tggtggtgaa tcgggctcaa acggcttagc cctggatcgc      300

caaggccgcc ttctgttgtg tcagcatggt gatcgtcgtg tagctcgttg ggagaaaggt      360

tgctttatca cactggcaga ccagtatgag ggcaaaccgc tgaattcccc gaatgacttg      420

gtagtcaagt cgaacggcga tatctacttc acggatccac catatggcat gactcctgag      480

gcccaacgcg atcccaatgc gctcggcttt tgcggcgttt atcgcattag tgcggatggg      540

aagctgacgc tgttagttcg tgacatgact cgccctaacg ggatcgcctt cagcccagac      600

gagaaaacgc tctatgttgc ccagtcagat ccgcaacgcc cgttatggat ggcgttcccg      660

gttcgcgaag atgggacctt aggggaaggc aaagtgttct tcgatgcgaa accgtggcag      720

caaagtggct tgccgggact cccagatggc atgaaagtgg accagaaagg caatctgttt      780

gcgactggtc cgggtggtgt caacatcttt cgccctgatg gtacctttct gggccggatt      840

cgggtgaaag tccctaccgc taactgtgcg tttggtgatg acggatctac gctttacatt      900

accgcggaca tgtatctgct tcgtgtgaaa acgaaaacca aaggactggg gttctaa         957


<210>  135
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Um 38 Aminosuren verkrzte Variante von Tt.Lac11

<400>  135

Met Glu Pro Ser Gln Asn Pro Ser Glu Lys Val Ala Trp Ile Glu Arg 
1               5                   10                  15      


Ala Asp Pro Gly Leu Asp Asp Leu Ile Ala Pro Asp Ala Gln Val Glu 
            20                  25                  30          


Val Leu Ala Glu Gly Phe Glu Trp Ser Glu Gly Pro Val Trp Ile Pro 
        35                  40                  45              


Glu Gly Gly Tyr Leu Leu Phe Ser Asp Val Pro Lys Asn Thr Ile Tyr 
    50                  55                  60                  


Arg Trp Lys Glu Gly Gln Gly Ile Asp Ile Phe Leu Lys Pro Ser Gly 
65                  70                  75                  80  


Tyr Thr Gly Phe Arg Glu Arg Gly Gly Glu Ser Gly Ser Asn Gly Leu 
                85                  90                  95      


Ala Leu Asp Arg Gln Gly Arg Leu Leu Leu Cys Gln His Gly Asp Arg 
            100                 105                 110         


Arg Val Ala Arg Trp Glu Lys Gly Cys Phe Ile Thr Leu Ala Asp Gln 
        115                 120                 125             


Tyr Glu Gly Lys Pro Leu Asn Ser Pro Asn Asp Leu Val Val Lys Ser 
    130                 135                 140                 


Asn Gly Asp Ile Tyr Phe Thr Asp Pro Pro Tyr Gly Met Thr Pro Glu 
145                 150                 155                 160 


Ala Gln Arg Asp Pro Asn Ala Leu Gly Phe Cys Gly Val Tyr Arg Ile 
                165                 170                 175     


Ser Ala Asp Gly Lys Leu Thr Leu Leu Val Arg Asp Met Thr Arg Pro 
            180                 185                 190         


Asn Gly Ile Ala Phe Ser Pro Asp Glu Lys Thr Leu Tyr Val Ala Gln 
        195                 200                 205             


Ser Asp Pro Gln Arg Pro Leu Trp Met Ala Phe Pro Val Arg Glu Asp 
    210                 215                 220                 


Gly Thr Leu Gly Glu Gly Lys Val Phe Phe Asp Ala Lys Pro Trp Gln 
225                 230                 235                 240 


Gln Ser Gly Leu Pro Gly Leu Pro Asp Gly Met Lys Val Asp Gln Lys 
                245                 250                 255     


Gly Asn Leu Phe Ala Thr Gly Pro Gly Gly Val Asn Ile Phe Arg Pro 
            260                 265                 270         


Asp Gly Thr Phe Leu Gly Arg Ile Arg Val Lys Val Pro Thr Ala Asn 
        275                 280                 285             


Cys Ala Phe Gly Asp Asp Gly Ser Thr Leu Tyr Ile Thr Ala Asp Met 
    290                 295                 300                 


Tyr Leu Leu Arg Val Lys Thr Lys Thr Lys Gly Leu Gly Phe 
305                 310                 315             


<210>  136
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr verkrzte Variante von Tt.lac11

<400>  136
atggaacgcg cagatcccgg cctcgacgat ctgattgctc cagatgcgca agtggaagtg       60

ctggcagaag gttttgagtg gagcgaaggt ccggtatgga ttcccgaagg cggctacttg      120

ctgtttagcg atgttccgaa gaacaccatt taccgctgga aagaaggtca ggggattgac      180

atcttcctga aaccgtcggg atataccggc tttcgtgaac gtggtggtga atcgggctca      240

aacggcttag ccctggatcg ccaaggccgc cttctgttgt gtcagcatgg tgatcgtcgt      300

gtagctcgtt gggagaaagg ttgctttatc acactggcag accagtatga gggcaaaccg      360

ctgaattccc cgaatgactt ggtagtcaag tcgaacggcg atatctactt cacggatcca      420

ccatatggca tgactcctga ggcccaacgc gatcccaatg cgctcggctt ttgcggcgtt      480

tatcgcatta gtgcggatgg gaagctgacg ctgttagttc gtgacatgac tcgccctaac      540

gggatcgcct tcagcccaga cgagaaaacg ctctatgttg cccagtcaga tccgcaacgc      600

ccgttatgga tggcgttccc ggttcgcgaa gatgggacct taggggaagg caaagtgttc      660

ttcgatgcga aaccgtggca gcaaagtggc ttgccgggac tcccagatgg catgaaagtg      720

gaccagaaag gcaatctgtt tgcgactggt ccgggtggtg tcaacatctt tcgccctgat      780

ggtacctttc tgggccggat tcgggtgaaa gtccctaccg ctaactgtgc gtttggtgat      840

gacggatcta cgctttacat taccgcggac atgtatctgc ttcgtgtgaa aacgaaaacc      900

aaaggactgg ggttctaa                                                    918


<210>  137
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Um 51 Aminosuren verkrzte Variante von Tt.Lac11

<400>  137

Met Glu Arg Ala Asp Pro Gly Leu Asp Asp Leu Ile Ala Pro Asp Ala 
1               5                   10                  15      


Gln Val Glu Val Leu Ala Glu Gly Phe Glu Trp Ser Glu Gly Pro Val 
            20                  25                  30          


Trp Ile Pro Glu Gly Gly Tyr Leu Leu Phe Ser Asp Val Pro Lys Asn 
        35                  40                  45              


Thr Ile Tyr Arg Trp Lys Glu Gly Gln Gly Ile Asp Ile Phe Leu Lys 
    50                  55                  60                  


Pro Ser Gly Tyr Thr Gly Phe Arg Glu Arg Gly Gly Glu Ser Gly Ser 
65                  70                  75                  80  


Asn Gly Leu Ala Leu Asp Arg Gln Gly Arg Leu Leu Leu Cys Gln His 
                85                  90                  95      


Gly Asp Arg Arg Val Ala Arg Trp Glu Lys Gly Cys Phe Ile Thr Leu 
            100                 105                 110         


Ala Asp Gln Tyr Glu Gly Lys Pro Leu Asn Ser Pro Asn Asp Leu Val 
        115                 120                 125             


Val Lys Ser Asn Gly Asp Ile Tyr Phe Thr Asp Pro Pro Tyr Gly Met 
    130                 135                 140                 


Thr Pro Glu Ala Gln Arg Asp Pro Asn Ala Leu Gly Phe Cys Gly Val 
145                 150                 155                 160 


Tyr Arg Ile Ser Ala Asp Gly Lys Leu Thr Leu Leu Val Arg Asp Met 
                165                 170                 175     


Thr Arg Pro Asn Gly Ile Ala Phe Ser Pro Asp Glu Lys Thr Leu Tyr 
            180                 185                 190         


Val Ala Gln Ser Asp Pro Gln Arg Pro Leu Trp Met Ala Phe Pro Val 
        195                 200                 205             


Arg Glu Asp Gly Thr Leu Gly Glu Gly Lys Val Phe Phe Asp Ala Lys 
    210                 215                 220                 


Pro Trp Gln Gln Ser Gly Leu Pro Gly Leu Pro Asp Gly Met Lys Val 
225                 230                 235                 240 


Asp Gln Lys Gly Asn Leu Phe Ala Thr Gly Pro Gly Gly Val Asn Ile 
                245                 250                 255     


Phe Arg Pro Asp Gly Thr Phe Leu Gly Arg Ile Arg Val Lys Val Pro 
            260                 265                 270         


Thr Ala Asn Cys Ala Phe Gly Asp Asp Gly Ser Thr Leu Tyr Ile Thr 
        275                 280                 285             


Ala Asp Met Tyr Leu Leu Arg Val Lys Thr Lys Thr Lys Gly Leu Gly 
    290                 295                 300                 


Phe 
305 


<210>  138
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr verkrzte Variante von Tt.lac11

<400>  138
atgtggagcg aaggtccggt atggattccc gaaggcggct acttgctgtt tagcgatgtt       60

ccgaagaaca ccatttaccg ctggaaagaa ggtcagggga ttgacatctt cctgaaaccg      120

tcgggatata ccggctttcg tgaacgtggt ggtgaatcgg gctcaaacgg cttagccctg      180

gatcgccaag gccgccttct gttgtgtcag catggtgatc gtcgtgtagc tcgttgggag      240

aaaggttgct ttatcacact ggcagaccag tatgagggca aaccgctgaa ttccccgaat      300

gacttggtag tcaagtcgaa cggcgatatc tacttcacgg atccaccata tggcatgact      360

cctgaggccc aacgcgatcc caatgcgctc ggcttttgcg gcgtttatcg cattagtgcg      420

gatgggaagc tgacgctgtt agttcgtgac atgactcgcc ctaacgggat cgccttcagc      480

ccagacgaga aaacgctcta tgttgcccag tcagatccgc aacgcccgtt atggatggcg      540

ttcccggttc gcgaagatgg gaccttaggg gaaggcaaag tgttcttcga tgcgaaaccg      600

tggcagcaaa gtggcttgcc gggactccca gatggcatga aagtggacca gaaaggcaat      660

ctgtttgcga ctggtccggg tggtgtcaac atctttcgcc ctgatggtac ctttctgggc      720

cggattcggg tgaaagtccc taccgctaac tgtgcgtttg gtgatgacgg atctacgctt      780

tacattaccg cggacatgta tctgcttcgt gtgaaaacga aaaccaaagg actggggttc      840

taa                                                                    843


<210>  139
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Um 76 Aminosuren verkrzte Variante von Tt.Lac11

<400>  139

Met Trp Ser Glu Gly Pro Val Trp Ile Pro Glu Gly Gly Tyr Leu Leu 
1               5                   10                  15      


Phe Ser Asp Val Pro Lys Asn Thr Ile Tyr Arg Trp Lys Glu Gly Gln 
            20                  25                  30          


Gly Ile Asp Ile Phe Leu Lys Pro Ser Gly Tyr Thr Gly Phe Arg Glu 
        35                  40                  45              


Arg Gly Gly Glu Ser Gly Ser Asn Gly Leu Ala Leu Asp Arg Gln Gly 
    50                  55                  60                  


Arg Leu Leu Leu Cys Gln His Gly Asp Arg Arg Val Ala Arg Trp Glu 
65                  70                  75                  80  


Lys Gly Cys Phe Ile Thr Leu Ala Asp Gln Tyr Glu Gly Lys Pro Leu 
                85                  90                  95      


Asn Ser Pro Asn Asp Leu Val Val Lys Ser Asn Gly Asp Ile Tyr Phe 
            100                 105                 110         


Thr Asp Pro Pro Tyr Gly Met Thr Pro Glu Ala Gln Arg Asp Pro Asn 
        115                 120                 125             


Ala Leu Gly Phe Cys Gly Val Tyr Arg Ile Ser Ala Asp Gly Lys Leu 
    130                 135                 140                 


Thr Leu Leu Val Arg Asp Met Thr Arg Pro Asn Gly Ile Ala Phe Ser 
145                 150                 155                 160 


Pro Asp Glu Lys Thr Leu Tyr Val Ala Gln Ser Asp Pro Gln Arg Pro 
                165                 170                 175     


Leu Trp Met Ala Phe Pro Val Arg Glu Asp Gly Thr Leu Gly Glu Gly 
            180                 185                 190         


Lys Val Phe Phe Asp Ala Lys Pro Trp Gln Gln Ser Gly Leu Pro Gly 
        195                 200                 205             


Leu Pro Asp Gly Met Lys Val Asp Gln Lys Gly Asn Leu Phe Ala Thr 
    210                 215                 220                 


Gly Pro Gly Gly Val Asn Ile Phe Arg Pro Asp Gly Thr Phe Leu Gly 
225                 230                 235                 240 


Arg Ile Arg Val Lys Val Pro Thr Ala Asn Cys Ala Phe Gly Asp Asp 
                245                 250                 255     


Gly Ser Thr Leu Tyr Ile Thr Ala Asp Met Tyr Leu Leu Arg Val Lys 
            260                 265                 270         


Thr Lys Thr Lys Gly Leu Gly Phe 
        275                 280 


<210>  140
<211>  1851
<212>  DNA
<213>  Escherichia coli

<400>  140
atgcctaagt accgttccgc caccaccact catggtcgta atatggcggg tgctcgtgcg       60

ctgtggcgcg ccaccggaat gaccgacgcc gatttcggta agccgattat cgcggttgtg      120

aactcgttca cccaatttgt accgggtcac gtccatctgc gcgatctcgg taaactggtc      180

gccgaacaaa ttgaagcggc tggcggcgtt gccaaagagt tcaacaccat tgcggtggat      240

gatgggattg ccatgggcca cggggggatg ctttattcac tgccatctcg cgaactgatc      300

gctgattccg ttgagtatat ggtcaacgcc cactgcgccg acgccatggt ctgcatctct      360

aactgcgaca aaatcacccc ggggatgctg atggcttccc tgcgcctgaa tattccggtg      420

atctttgttt ccggcggccc gatggaggcc gggaaaacca aactttccga tcagatcatc      480

aagctcgatc tggttgatgc gatgatccag ggcgcagacc cgaaagtatc tgactcccag      540

agcgatcagg ttgaacgttc cgcgtgtccg acctgcggtt cctgctccgg gatgtttacc      600

gctaactcaa tgaactgcct gaccgaagcg ctgggcctgt cgcagccggg caacggctcg      660

ctgctggcaa cccacgccga ccgtaagcag ctgttcctta atgctggtaa acgcattgtt      720

gaattgacca aacgttatta cgagcaaaac gacgaaagtg cactgccgcg taatatcgcc      780

agtaaggcgg cgtttgaaaa cgccatgacg ctggatatcg cgatgggtgg atcgactaac      840

accgtacttc acctgctggc ggcggcgcag gaagcggaaa tcgacttcac catgagtgat      900

atcgataagc tttcccgcaa ggttccacag ctgtgtaaag ttgcgccgag cacccagaaa      960

taccatatgg aagatgttca ccgtgctggt ggtgttatcg gtattctcgg cgaactggat     1020

cgcgcggggt tactgaaccg tgatgtgaaa aacgtacttg gcctgacgtt gccgcaaacg     1080

ctggaacaat acgacgttat gctgacccag gatgacgcgg taaaaaatat gttccgcgca     1140

ggtcctgcag gcattcgtac cacacaggca ttctcgcaag attgccgttg ggatacgctg     1200

gacgacgatc gcgccaatgg ctgtatccgc tcgctggaac acgcctacag caaagacggc     1260

ggcctggcgg tgctctacgg taactttgcg gaaaacggct gcatcgtgaa aacggcaggc     1320

gtcgatgaca gcatcctcaa attcaccggc ccggcgaaag tgtacgaaag ccaggacgat     1380

gcggtagaag cgattctcgg cggtaaagtt gtcgccggag atgtggtagt aattcgctat     1440

gaaggcccga aaggcggtcc ggggatgcag gaaatgctct acccaaccag cttcctgaaa     1500

tcaatgggtc tcggcaaagc ctgtgcgctg atcaccgacg gtcgtttctc tggtggcacc     1560

tctggtcttt ccatcggcca cgtctcaccg gaagcggcaa gcggcggcag cattggcctg     1620

attgaagatg gtgacctgat cgctatcgac atcccgaacc gtggcattca gttacaggta     1680

agcgatgccg aactggcggc gcgtcgtgaa gcgcaggacg ctcgaggtga caaagcctgg     1740

acgccgaaaa atcgtgaacg tcaggtctcc tttgccctgc gtgcttatgc cagcctggca     1800

accagcgccg acaaaggcgc ggtgcgcgat aaatcgaaac tggggggtta a              1851


<210>  141
<211>  616
<212>  PRT
<213>  Escherichia coli

<400>  141

Met Pro Lys Tyr Arg Ser Ala Thr Thr Thr His Gly Arg Asn Met Ala 
1               5                   10                  15      


Gly Ala Arg Ala Leu Trp Arg Ala Thr Gly Met Thr Asp Ala Asp Phe 
            20                  25                  30          


Gly Lys Pro Ile Ile Ala Val Val Asn Ser Phe Thr Gln Phe Val Pro 
        35                  40                  45              


Gly His Val His Leu Arg Asp Leu Gly Lys Leu Val Ala Glu Gln Ile 
    50                  55                  60                  


Glu Ala Ala Gly Gly Val Ala Lys Glu Phe Asn Thr Ile Ala Val Asp 
65                  70                  75                  80  


Asp Gly Ile Ala Met Gly His Gly Gly Met Leu Tyr Ser Leu Pro Ser 
                85                  90                  95      


Arg Glu Leu Ile Ala Asp Ser Val Glu Tyr Met Val Asn Ala His Cys 
            100                 105                 110         


Ala Asp Ala Met Val Cys Ile Ser Asn Cys Asp Lys Ile Thr Pro Gly 
        115                 120                 125             


Met Leu Met Ala Ser Leu Arg Leu Asn Ile Pro Val Ile Phe Val Ser 
    130                 135                 140                 


Gly Gly Pro Met Glu Ala Gly Lys Thr Lys Leu Ser Asp Gln Ile Ile 
145                 150                 155                 160 


Lys Leu Asp Leu Val Asp Ala Met Ile Gln Gly Ala Asp Pro Lys Val 
                165                 170                 175     


Ser Asp Ser Gln Ser Asp Gln Val Glu Arg Ser Ala Cys Pro Thr Cys 
            180                 185                 190         


Gly Ser Cys Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Leu Thr 
        195                 200                 205             


Glu Ala Leu Gly Leu Ser Gln Pro Gly Asn Gly Ser Leu Leu Ala Thr 
    210                 215                 220                 


His Ala Asp Arg Lys Gln Leu Phe Leu Asn Ala Gly Lys Arg Ile Val 
225                 230                 235                 240 


Glu Leu Thr Lys Arg Tyr Tyr Glu Gln Asn Asp Glu Ser Ala Leu Pro 
                245                 250                 255     


Arg Asn Ile Ala Ser Lys Ala Ala Phe Glu Asn Ala Met Thr Leu Asp 
            260                 265                 270         


Ile Ala Met Gly Gly Ser Thr Asn Thr Val Leu His Leu Leu Ala Ala 
        275                 280                 285             


Ala Gln Glu Ala Glu Ile Asp Phe Thr Met Ser Asp Ile Asp Lys Leu 
    290                 295                 300                 


Ser Arg Lys Val Pro Gln Leu Cys Lys Val Ala Pro Ser Thr Gln Lys 
305                 310                 315                 320 


Tyr His Met Glu Asp Val His Arg Ala Gly Gly Val Ile Gly Ile Leu 
                325                 330                 335     


Gly Glu Leu Asp Arg Ala Gly Leu Leu Asn Arg Asp Val Lys Asn Val 
            340                 345                 350         


Leu Gly Leu Thr Leu Pro Gln Thr Leu Glu Gln Tyr Asp Val Met Leu 
        355                 360                 365             


Thr Gln Asp Asp Ala Val Lys Asn Met Phe Arg Ala Gly Pro Ala Gly 
    370                 375                 380                 


Ile Arg Thr Thr Gln Ala Phe Ser Gln Asp Cys Arg Trp Asp Thr Leu 
385                 390                 395                 400 


Asp Asp Asp Arg Ala Asn Gly Cys Ile Arg Ser Leu Glu His Ala Tyr 
                405                 410                 415     


Ser Lys Asp Gly Gly Leu Ala Val Leu Tyr Gly Asn Phe Ala Glu Asn 
            420                 425                 430         


Gly Cys Ile Val Lys Thr Ala Gly Val Asp Asp Ser Ile Leu Lys Phe 
        435                 440                 445             


Thr Gly Pro Ala Lys Val Tyr Glu Ser Gln Asp Asp Ala Val Glu Ala 
    450                 455                 460                 


Ile Leu Gly Gly Lys Val Val Ala Gly Asp Val Val Val Ile Arg Tyr 
465                 470                 475                 480 


Glu Gly Pro Lys Gly Gly Pro Gly Met Gln Glu Met Leu Tyr Pro Thr 
                485                 490                 495     


Ser Phe Leu Lys Ser Met Gly Leu Gly Lys Ala Cys Ala Leu Ile Thr 
            500                 505                 510         


Asp Gly Arg Phe Ser Gly Gly Thr Ser Gly Leu Ser Ile Gly His Val 
        515                 520                 525             


Ser Pro Glu Ala Ala Ser Gly Gly Ser Ile Gly Leu Ile Glu Asp Gly 
    530                 535                 540                 


Asp Leu Ile Ala Ile Asp Ile Pro Asn Arg Gly Ile Gln Leu Gln Val 
545                 550                 555                 560 


Ser Asp Ala Glu Leu Ala Ala Arg Arg Glu Ala Gln Asp Ala Arg Gly 
                565                 570                 575     


Asp Lys Ala Trp Thr Pro Lys Asn Arg Glu Arg Gln Val Ser Phe Ala 
            580                 585                 590         


Leu Arg Ala Tyr Ala Ser Leu Ala Thr Ser Ala Asp Lys Gly Ala Val 
        595                 600                 605             


Arg Asp Lys Ser Lys Leu Gly Gly 
    610                 615     


<210>  142
<211>  1677
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr Ss.IlvD

<400>  142
atgccggcaa aattaaattc accgagccgt tatcatggta tttacaatgc accgcaccgc       60

gccttcttac gtagcgtggg tttaacagat gaggagatcg gcaaaccgct ggtggcaatc      120

gccaccgcat ggagcgaagc tggtccgtgt aatttccaca ctttagcttt agcccgtgtt      180

gccaaagagg gtaccaagga agctggtctg agccctctgg cattcccgac catggtggtg      240

aacgacaata tcggcatggg cagcgaaggc atgcgttatt ctctggtgag tcgcgatctg      300

atcgccgata tggtggaggc ccagtttaac gcccacgcat tcgatggctt agtgggcatc      360

ggcggctgcg ataagaccac cccgggcatt ttaatggcca tggcccgttt aaatgtgccg      420

agcatttata tttacggcgg tagcgccgaa ccgggctatt ttatgggcaa gcgtttaaca      480

atcgaggacg ttcatgaagc catcggcgca tatttagcca agcgcattac agaaaacgaa      540

ctgtatgaaa ttgaaaaacg cgcccaccct acactgggta cttgtagcgg tctgttcacc      600

gccaacacca tgggtagtat gagcgaagca ctgggcatgg ctttaccggg tagtgcaagt      660

ccgacagcaa caagcagccg ccgtgttatg tatgtgaaag agaccggcaa agcactgggt      720

tctttaattg aaaatggcat caagagccgc gagattttaa cctttgaagc attcgagaac      780

gccatcacca ctttaatggc tatgggtggt agcacaaatg cagtgctgca tctgctggcc      840

attgcatacg aagccggcgt gaaactgact ttagatgact tcaaccgcat cagcaagcgt      900

acaccgtata tcgccagcat gaaacccggt ggtgattatg tgatggccga tttagatgaa      960

gttggcggcg tgccggtggt gctgaaaaaa ctgctggacg ccggtttact gcatggcgat     1020

gttctgaccg tgaccggtaa gaccatgaag cagaatttag agcagtacaa gtaccctaac     1080

gtgccgcata gccatatcgt gcgtgatgtg aagaacccga tcaaaccgcg cggcggtatc     1140

gttattttaa aaggctcttt agcccccgaa ggcgcagtta ttaaagtggc cgccaccaac     1200

gtggttaagt tcgaaggcaa ggccaaggtg tacaatagcg aggacgatgc cttcaaaggc     1260

gtgcaaagtg gcgaggtgag tgagggtgaa gttgtgatca tccgctatga gggtccgaaa     1320

ggcgcaccgg gtatgcccga aatgctgcgt gttaccgccg ccatcatggg tgccggttta     1380

aacaatgtgg cactggttac cgacggtcgt tttagcggcg caacacgcgg tccgatggtt     1440

ggtcatgttg caccggaggc aatggttggc ggcccgatcg caattgtgga agacggtgac     1500

accattgtga tcgatgtgga gagtgagcgt ttagatctga aactgagcga agaggagatc     1560

aaaaatcgtc tgaaacgttg gagcccgccg agccctcgct acaaaagtgg tttactggca     1620

aaatacgcca gtctggttag tcaagctagc atgggcgcag tgacccgtcc cgcttaa        1677


<210>  143
<211>  558
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  143

Met Pro Ala Lys Leu Asn Ser Pro Ser Arg Tyr His Gly Ile Tyr Asn 
1               5                   10                  15      


Ala Pro His Arg Ala Phe Leu Arg Ser Val Gly Leu Thr Asp Glu Glu 
            20                  25                  30          


Ile Gly Lys Pro Leu Val Ala Ile Ala Thr Ala Trp Ser Glu Ala Gly 
        35                  40                  45              


Pro Cys Asn Phe His Thr Leu Ala Leu Ala Arg Val Ala Lys Glu Gly 
    50                  55                  60                  


Thr Lys Glu Ala Gly Leu Ser Pro Leu Ala Phe Pro Thr Met Val Val 
65                  70                  75                  80  


Asn Asp Asn Ile Gly Met Gly Ser Glu Gly Met Arg Tyr Ser Leu Val 
                85                  90                  95      


Ser Arg Asp Leu Ile Ala Asp Met Val Glu Ala Gln Phe Asn Ala His 
            100                 105                 110         


Ala Phe Asp Gly Leu Val Gly Ile Gly Gly Cys Asp Lys Thr Thr Pro 
        115                 120                 125             


Gly Ile Leu Met Ala Met Ala Arg Leu Asn Val Pro Ser Ile Tyr Ile 
    130                 135                 140                 


Tyr Gly Gly Ser Ala Glu Pro Gly Tyr Phe Met Gly Lys Arg Leu Thr 
145                 150                 155                 160 


Ile Glu Asp Val His Glu Ala Ile Gly Ala Tyr Leu Ala Lys Arg Ile 
                165                 170                 175     


Thr Glu Asn Glu Leu Tyr Glu Ile Glu Lys Arg Ala His Pro Thr Leu 
            180                 185                 190         


Gly Thr Cys Ser Gly Leu Phe Thr Ala Asn Thr Met Gly Ser Met Ser 
        195                 200                 205             


Glu Ala Leu Gly Met Ala Leu Pro Gly Ser Ala Ser Pro Thr Ala Thr 
    210                 215                 220                 


Ser Ser Arg Arg Val Met Tyr Val Lys Glu Thr Gly Lys Ala Leu Gly 
225                 230                 235                 240 


Ser Leu Ile Glu Asn Gly Ile Lys Ser Arg Glu Ile Leu Thr Phe Glu 
                245                 250                 255     


Ala Phe Glu Asn Ala Ile Thr Thr Leu Met Ala Met Gly Gly Ser Thr 
            260                 265                 270         


Asn Ala Val Leu His Leu Leu Ala Ile Ala Tyr Glu Ala Gly Val Lys 
        275                 280                 285             


Leu Thr Leu Asp Asp Phe Asn Arg Ile Ser Lys Arg Thr Pro Tyr Ile 
    290                 295                 300                 


Ala Ser Met Lys Pro Gly Gly Asp Tyr Val Met Ala Asp Leu Asp Glu 
305                 310                 315                 320 


Val Gly Gly Val Pro Val Val Leu Lys Lys Leu Leu Asp Ala Gly Leu 
                325                 330                 335     


Leu His Gly Asp Val Leu Thr Val Thr Gly Lys Thr Met Lys Gln Asn 
            340                 345                 350         


Leu Glu Gln Tyr Lys Tyr Pro Asn Val Pro His Ser His Ile Val Arg 
        355                 360                 365             


Asp Val Lys Asn Pro Ile Lys Pro Arg Gly Gly Ile Val Ile Leu Lys 
    370                 375                 380                 


Gly Ser Leu Ala Pro Glu Gly Ala Val Ile Lys Val Ala Ala Thr Asn 
385                 390                 395                 400 


Val Val Lys Phe Glu Gly Lys Ala Lys Val Tyr Asn Ser Glu Asp Asp 
                405                 410                 415     


Ala Phe Lys Gly Val Gln Ser Gly Glu Val Ser Glu Gly Glu Val Val 
            420                 425                 430         


Ile Ile Arg Tyr Glu Gly Pro Lys Gly Ala Pro Gly Met Pro Glu Met 
        435                 440                 445             


Leu Arg Val Thr Ala Ala Ile Met Gly Ala Gly Leu Asn Asn Val Ala 
    450                 455                 460                 


Leu Val Thr Asp Gly Arg Phe Ser Gly Ala Thr Arg Gly Pro Met Val 
465                 470                 475                 480 


Gly His Val Ala Pro Glu Ala Met Val Gly Gly Pro Ile Ala Ile Val 
                485                 490                 495     


Glu Asp Gly Asp Thr Ile Val Ile Asp Val Glu Ser Glu Arg Leu Asp 
            500                 505                 510         


Leu Lys Leu Ser Glu Glu Glu Ile Lys Asn Arg Leu Lys Arg Trp Ser 
        515                 520                 525             


Pro Pro Ser Pro Arg Tyr Lys Ser Gly Leu Leu Ala Lys Tyr Ala Ser 
    530                 535                 540                 


Leu Val Ser Gln Ala Ser Met Gly Ala Val Thr Arg Pro Ala 
545                 550                 555             


<210>  144
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codonoptimierte Sequenz fr Xc.FucD

<400>  144
atgcgtacca ttatcgcttt agaaacccat gatgttcgct ttccgacaag ccgtgagctg       60

gatggcagcg acgcaatgaa cccggacccg gactatagcg ccgcctacgt tgttctgcgt      120

acagatggcg cagaagatct ggccggctac ggtctggtgt ttaccattgg tcgcggcaac      180

gatgttcaga cagcagccgt ggcagcttta gcagaacacg tggtgggttt aagcgttgac      240

aaggtgattg ccgatctggg tgcatttgca cgccgtttaa ccaatgatag ccaactgcgt      300

tggctgggtc cggaaaaagg cgtgatgcac atggccatcg gcgccgttat taatgccgca      360

tgggatctgg cagcacgcgc cgcaaataaa ccgctgtggc gctttatcgc cgaactgacc      420

ccggaacagc tggtggacac catcgacttt cgctatctga gcgatgcact gacccgtgat      480

gaagcactgg caattctgcg tgatgcacag ccgcagcgtg cagcacgtac cgccacactg      540

atcgagcaag gttatccggc atataccacc agcccgggct ggctgggcta cagtgacgaa      600

aaattagtgc gtttagccaa ggaagccgtt gccgatggct tccgcaccat taaactgaaa      660

gtgggcgcca acgtgcaaga tgatattcgc cgttgccgtc tggcacgtgc cgcaattggt      720

ccggacatcg ccatggcagt ggatgccaac cagcgctggg atgttggtcc ggccattgat      780

tggatgcgcc agctggccga gtttgatatc gcttggattg aggaaccgac aagtccggat      840

gatgtgctgg gccatgcagc aatccgtcaa ggtatcaccc cggttccggt gagtaccggc      900

gaacacaccc agaaccgcgt tgttttcaaa cagctgctgc aagctggtgc cgtggatctg      960

attcaaatcg atgccgcccg tgttggcggc gttaatgaga atttagccat tttactgctg     1020

gccgccaaat tcggcgtgcg tgtgtttccg catgctggtg gcgtgggtct gtgcgaactg     1080

gttcagcatc tggcaatggc cgatttcgtt gcaattaccg gcaagatgga ggatcgtgcc     1140

atcgagtttg tggatcatct gcaccagcac tttttagacc cggtgcgcat tcagcacggt     1200

cgctatctgg ccccggaagt tccgggtttc agcgccgaaa tgcacccggc aagcattgcc     1260

gagtttagct acccggacgg ccgtttctgg gttgaagatt tagccgccag caaagccaaa     1320

gcctaa                                                                1326


<210>  145
<211>  441
<212>  PRT
<213>  Xanthomonas campestris

<400>  145

Met Arg Thr Ile Ile Ala Leu Glu Thr His Asp Val Arg Phe Pro Thr 
1               5                   10                  15      


Ser Arg Glu Leu Asp Gly Ser Asp Ala Met Asn Pro Asp Pro Asp Tyr 
            20                  25                  30          


Ser Ala Ala Tyr Val Val Leu Arg Thr Asp Gly Ala Glu Asp Leu Ala 
        35                  40                  45              


Gly Tyr Gly Leu Val Phe Thr Ile Gly Arg Gly Asn Asp Val Gln Thr 
    50                  55                  60                  


Ala Ala Val Ala Ala Leu Ala Glu His Val Val Gly Leu Ser Val Asp 
65                  70                  75                  80  


Lys Val Ile Ala Asp Leu Gly Ala Phe Ala Arg Arg Leu Thr Asn Asp 
                85                  90                  95      


Ser Gln Leu Arg Trp Leu Gly Pro Glu Lys Gly Val Met His Met Ala 
            100                 105                 110         


Ile Gly Ala Val Ile Asn Ala Ala Trp Asp Leu Ala Ala Arg Ala Ala 
        115                 120                 125             


Asn Lys Pro Leu Trp Arg Phe Ile Ala Glu Leu Thr Pro Glu Gln Leu 
    130                 135                 140                 


Val Asp Thr Ile Asp Phe Arg Tyr Leu Ser Asp Ala Leu Thr Arg Asp 
145                 150                 155                 160 


Glu Ala Leu Ala Ile Leu Arg Asp Ala Gln Pro Gln Arg Ala Ala Arg 
                165                 170                 175     


Thr Ala Thr Leu Ile Glu Gln Gly Tyr Pro Ala Tyr Thr Thr Ser Pro 
            180                 185                 190         


Gly Trp Leu Gly Tyr Ser Asp Glu Lys Leu Val Arg Leu Ala Lys Glu 
        195                 200                 205             


Ala Val Ala Asp Gly Phe Arg Thr Ile Lys Leu Lys Val Gly Ala Asn 
    210                 215                 220                 


Val Gln Asp Asp Ile Arg Arg Cys Arg Leu Ala Arg Ala Ala Ile Gly 
225                 230                 235                 240 


Pro Asp Ile Ala Met Ala Val Asp Ala Asn Gln Arg Trp Asp Val Gly 
                245                 250                 255     


Pro Ala Ile Asp Trp Met Arg Gln Leu Ala Glu Phe Asp Ile Ala Trp 
            260                 265                 270         


Ile Glu Glu Pro Thr Ser Pro Asp Asp Val Leu Gly His Ala Ala Ile 
        275                 280                 285             


Arg Gln Gly Ile Thr Pro Val Pro Val Ser Thr Gly Glu His Thr Gln 
    290                 295                 300                 


Asn Arg Val Val Phe Lys Gln Leu Leu Gln Ala Gly Ala Val Asp Leu 
305                 310                 315                 320 


Ile Gln Ile Asp Ala Ala Arg Val Gly Gly Val Asn Glu Asn Leu Ala 
                325                 330                 335     


Ile Leu Leu Leu Ala Ala Lys Phe Gly Val Arg Val Phe Pro His Ala 
            340                 345                 350         


Gly Gly Val Gly Leu Cys Glu Leu Val Gln His Leu Ala Met Ala Asp 
        355                 360                 365             


Phe Val Ala Ile Thr Gly Lys Met Glu Asp Arg Ala Ile Glu Phe Val 
    370                 375                 380                 


Asp His Leu His Gln His Phe Leu Asp Pro Val Arg Ile Gln His Gly 
385                 390                 395                 400 


Arg Tyr Leu Ala Pro Glu Val Pro Gly Phe Ser Ala Glu Met His Pro 
                405                 410                 415     


Ala Ser Ile Ala Glu Phe Ser Tyr Pro Asp Gly Arg Phe Trp Val Glu 
            420                 425                 430         


Asp Leu Ala Ala Ser Lys Ala Lys Ala 
        435                 440     


<210>  146
<211>  1236
<212>  DNA
<213>  Pseudomonas putida

<400>  146
atgaacagtg cccccgacta ttcggcggcc tacgtggtgc tgcacaccga cgctgccgcc       60

ctcgaaggcc acggcctgac cttcaccatc ggccgtggca acgaaatatg cgcagcagcg      120

gtgcagtcgc tggccccctt gatcgtcggc cttacgctcg aagaaatcag cgccgacatg      180

ggcgctttct ggcatcgctt taccgtcagc gacagccagt tgcgctggct gggcccggaa      240

aagggcgtga tccacctggc caccgccgcc atcatcaacg cagtgtggga cctgtgggcc      300

aagcacgaag gcaagcccgt gtggaaactg ctggccgaca tgacgccgga gcagctggtg      360

cgctgcctgg acttcagcta cgtcaccgac gtgctcaccc ccgaagaggc catcgccctg      420

ctgcgccgcc aggcgccggg caaagccgag cgcgaggcac acatgctgcg tgaaggctac      480

cccgggtaca ccactgcccc gggctggctg ggctacagcg aagagaaaat gcgcaaactg      540

gcccgcgagg ccgtggcaga cggctggacc cacatcaaac agaagatcgg ggccgacctg      600

gaagaagaca tccgccgcgc cagcatcctg cgcgacgaaa tcggctggga acgcaccctg      660

atgatggatg ccaaccaagt gtggggcgtc gaagagtcgg tggccaacat gcgccgcctg      720

gccgcattcg aaccgctttg gatcgaagaa ccgaccagcc ccgatgacat tcttggccac      780

gccaccattc gccagcgcat tgcgccaatc ggtgtcgcca ccggtgagca ttgccacaac      840

cgggtgatgt tcaagcagat gttccaggcc ggtgcactgg acttctgcca gctggacgca      900

gcccgcctgg gtggcctgaa cgaggtcctg atcgtgctgc tgatggccgc caagtacgac      960

gtgccggtct gcccgcacgg cggtggcgtc gggctgtgcg aatatgtgca gaacatcgcg     1020

cttttcgact acatcgcggt ttctgcctcg ctgcacaacc gggtgctgga gtacgtcgac     1080

cacctgcacg agcacttcat cgacccggtg gtgatccatc gcgggcgcta catgccgcca     1140

caacgccctg gctacagcat cgagatgcac gctgagaccc tggaacgtta ccagtacccc     1200

aacggcgccg tgtggctcga catcaaccgt tcctga                               1236


<210>  147
<211>  411
<212>  PRT
<213>  Pseudomonas putida

<400>  147

Met Asn Ser Ala Pro Asp Tyr Ser Ala Ala Tyr Val Val Leu His Thr 
1               5                   10                  15      


Asp Ala Ala Ala Leu Glu Gly His Gly Leu Thr Phe Thr Ile Gly Arg 
            20                  25                  30          


Gly Asn Glu Ile Cys Ala Ala Ala Val Gln Ser Leu Ala Pro Leu Ile 
        35                  40                  45              


Val Gly Leu Thr Leu Glu Glu Ile Ser Ala Asp Met Gly Ala Phe Trp 
    50                  55                  60                  


His Arg Phe Thr Val Ser Asp Ser Gln Leu Arg Trp Leu Gly Pro Glu 
65                  70                  75                  80  


Lys Gly Val Ile His Leu Ala Thr Ala Ala Ile Ile Asn Ala Val Trp 
                85                  90                  95      


Asp Leu Trp Ala Lys His Glu Gly Lys Pro Val Trp Lys Leu Leu Ala 
            100                 105                 110         


Asp Met Thr Pro Glu Gln Leu Val Arg Cys Leu Asp Phe Ser Tyr Val 
        115                 120                 125             


Thr Asp Val Leu Thr Pro Glu Glu Ala Ile Ala Leu Leu Arg Arg Gln 
    130                 135                 140                 


Ala Pro Gly Lys Ala Glu Arg Glu Ala His Met Leu Arg Glu Gly Tyr 
145                 150                 155                 160 


Pro Gly Tyr Thr Thr Ala Pro Gly Trp Leu Gly Tyr Ser Glu Glu Lys 
                165                 170                 175     


Met Arg Lys Leu Ala Arg Glu Ala Val Ala Asp Gly Trp Thr His Ile 
            180                 185                 190         


Lys Gln Lys Ile Gly Ala Asp Leu Glu Glu Asp Ile Arg Arg Ala Ser 
        195                 200                 205             


Ile Leu Arg Asp Glu Ile Gly Trp Glu Arg Thr Leu Met Met Asp Ala 
    210                 215                 220                 


Asn Gln Val Trp Gly Val Glu Glu Ser Val Ala Asn Met Arg Arg Leu 
225                 230                 235                 240 


Ala Ala Phe Glu Pro Leu Trp Ile Glu Glu Pro Thr Ser Pro Asp Asp 
                245                 250                 255     


Ile Leu Gly His Ala Thr Ile Arg Gln Arg Ile Ala Pro Ile Gly Val 
            260                 265                 270         


Ala Thr Gly Glu His Cys His Asn Arg Val Met Phe Lys Gln Met Phe 
        275                 280                 285             


Gln Ala Gly Ala Leu Asp Phe Cys Gln Leu Asp Ala Ala Arg Leu Gly 
    290                 295                 300                 


Gly Leu Asn Glu Val Leu Ile Val Leu Leu Met Ala Ala Lys Tyr Asp 
305                 310                 315                 320 


Val Pro Val Cys Pro His Gly Gly Gly Val Gly Leu Cys Glu Tyr Val 
                325                 330                 335     


Gln Asn Ile Ala Leu Phe Asp Tyr Ile Ala Val Ser Ala Ser Leu His 
            340                 345                 350         


Asn Arg Val Leu Glu Tyr Val Asp His Leu His Glu His Phe Ile Asp 
        355                 360                 365             


Pro Val Val Ile His Arg Gly Arg Tyr Met Pro Pro Gln Arg Pro Gly 
    370                 375                 380                 


Tyr Ser Ile Glu Met His Ala Glu Thr Leu Glu Arg Tyr Gln Tyr Pro 
385                 390                 395                 400 


Asn Gly Ala Val Trp Leu Asp Ile Asn Arg Ser 
                405                 410     


<210>  148
<211>  1170
<212>  DNA
<213>  Bradyrhizobium japonicum

<400>  148
atgtccgtcc gcatcgtcga cgtccgcgag atcaccaagc cgatctcatc gccgatccgc       60

aacgcctata tcgatttcac caagatgacg acgagcctcg tcgccgtcgt cactgacgtt      120

gtgcgcgaag gcaagcgcgt cgtcggctac ggcttcaatt ccaacggccg ctacgggcag      180

ggcggcctga tccgcgaacg cttcgcctcg cgcatcctgg aggccgatcc gaagaagctt      240

ctgaacgagg ccggcgacaa tctcgatccc gacaaggtct gggccgcgat gatgatcaac      300

gagaagccgg gcggccatgg cgagcgctcg gtcgcggtcg gcaccatcga catggcggtg      360

tgggacgcgg tggcgaagat cgcgggcaag ccgctgtttc gcctgctcgc cgaacgtcac      420

ggcgtcaaag ccaacccgcg cgtgttcgtc tatgccgccg gcggctacta ctatcccggc      480

aaggggctat cgatgctgcg cggcgagatg cgtggctatc tcgaccgcgg ctacaacgtc      540

gtgaagatga agatcggcgg cgcgccgatc gaggaggatc gcatgcgcat cgaggcggtg      600

ctggaggaga tcggcaagga cgcgcagctc gccgtcgacg ccaacggccg cttcaacctc      660

gagaccggca tcgcctatgc caagatgctg cgcgattatc cgctgttctg gtacgaggag      720

gtcggcgatc ccctcgacta cgcgctgcag gccgcgctcg ccgaattcta tcccggcccg      780

atggcgacag gcgaaaacct gttcagccac caggacgcgc gcaacctgct ccgctatggc      840

ggcatgcgcc cggaccgcga ctggctgcaa ttcgactgcg cgctgtccta tggcctctgc      900

gaataccagc gcacgctcga agtgctgaag acccatggct ggtcgccaag ccgctgcatc      960

ccgcatggcg gccaccagat gtcgctcaac atcgccgctg gcctcggcct cggcggcaac     1020

gaaagctacc cggacctgtt ccagccctac ggcggcttcc ccgacggcgt gcgcgtcgag     1080

aacggccaca tcaccatgcc ggaccttccg ggcatcggct tcgaaggcaa gtcggatctc     1140

tacaaggaga tgaaggcgct ggcggagtaa                                      1170


<210>  149
<211>  389
<212>  PRT
<213>  Bradyrhizobium japonicum

<400>  149

Met Ser Val Arg Ile Val Asp Val Arg Glu Ile Thr Lys Pro Ile Ser 
1               5                   10                  15      


Ser Pro Ile Arg Asn Ala Tyr Ile Asp Phe Thr Lys Met Thr Thr Ser 
            20                  25                  30          


Leu Val Ala Val Val Thr Asp Val Val Arg Glu Gly Lys Arg Val Val 
        35                  40                  45              


Gly Tyr Gly Phe Asn Ser Asn Gly Arg Tyr Gly Gln Gly Gly Leu Ile 
    50                  55                  60                  


Arg Glu Arg Phe Ala Ser Arg Ile Leu Glu Ala Asp Pro Lys Lys Leu 
65                  70                  75                  80  


Leu Asn Glu Ala Gly Asp Asn Leu Asp Pro Asp Lys Val Trp Ala Ala 
                85                  90                  95      


Met Met Ile Asn Glu Lys Pro Gly Gly His Gly Glu Arg Ser Val Ala 
            100                 105                 110         


Val Gly Thr Ile Asp Met Ala Val Trp Asp Ala Val Ala Lys Ile Ala 
        115                 120                 125             


Gly Lys Pro Leu Phe Arg Leu Leu Ala Glu Arg His Gly Val Lys Ala 
    130                 135                 140                 


Asn Pro Arg Val Phe Val Tyr Ala Ala Gly Gly Tyr Tyr Tyr Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Ser Met Leu Arg Gly Glu Met Arg Gly Tyr Leu Asp Arg 
                165                 170                 175     


Gly Tyr Asn Val Val Lys Met Lys Ile Gly Gly Ala Pro Ile Glu Glu 
            180                 185                 190         


Asp Arg Met Arg Ile Glu Ala Val Leu Glu Glu Ile Gly Lys Asp Ala 
        195                 200                 205             


Gln Leu Ala Val Asp Ala Asn Gly Arg Phe Asn Leu Glu Thr Gly Ile 
    210                 215                 220                 


Ala Tyr Ala Lys Met Leu Arg Asp Tyr Pro Leu Phe Trp Tyr Glu Glu 
225                 230                 235                 240 


Val Gly Asp Pro Leu Asp Tyr Ala Leu Gln Ala Ala Leu Ala Glu Phe 
                245                 250                 255     


Tyr Pro Gly Pro Met Ala Thr Gly Glu Asn Leu Phe Ser His Gln Asp 
            260                 265                 270         


Ala Arg Asn Leu Leu Arg Tyr Gly Gly Met Arg Pro Asp Arg Asp Trp 
        275                 280                 285             


Leu Gln Phe Asp Cys Ala Leu Ser Tyr Gly Leu Cys Glu Tyr Gln Arg 
    290                 295                 300                 


Thr Leu Glu Val Leu Lys Thr His Gly Trp Ser Pro Ser Arg Cys Ile 
305                 310                 315                 320 


Pro His Gly Gly His Gln Met Ser Leu Asn Ile Ala Ala Gly Leu Gly 
                325                 330                 335     


Leu Gly Gly Asn Glu Ser Tyr Pro Asp Leu Phe Gln Pro Tyr Gly Gly 
            340                 345                 350         


Phe Pro Asp Gly Val Arg Val Glu Asn Gly His Ile Thr Met Pro Asp 
        355                 360                 365             


Leu Pro Gly Ile Gly Phe Glu Gly Lys Ser Asp Leu Tyr Lys Glu Met 
    370                 375                 380                 


Lys Ala Leu Ala Glu 
385                 


<210>  150
<211>  1539
<212>  DNA
<213>  Acidovorax avenae

<400>  150
atgtcgactg atgcactggc gacgcagtcg ctgctcatcc tgaacgaccg cgacaacgtg       60

gctgtcgcgc gcaccgaact cggcgcgggc atggagcttc ggctggccgg cggcgaagta      120

ctggaggtga tggccactgt gcccgccggc cacaagatcg cactcaggcc catcgcgaag      180

ggcgatgccg tgctgaagta cggccaggtc atcggcgctg ccagcacgcc gatcggggcc      240

ggcgagcacg tgcatgtgca caacgtcgag atgggcgact ccagccccac ccacctggtg      300

ggccgcgcct acgtcccgac cgatcccgtg gagcagcctg cgaccttcat gggctacgtc      360

agggccgatg ggcgcgtcgg cacgcgcaac tacatcggcg tcatttcttc ggtgaactgc      420

tccgccacgg tctgcaaggc catcgcgcag gccttcacgg gcccggcgct cggtgcctat      480

ccgggtgtgg acggtgtcgt cgccatcacg cacggcaccg gctgcggcat gagcggtgaa      540

ggcgaaggca tcgaactcct gcgccgcacg ctcagcggct acatcgccca ccccaatttc      600

gccgcggtgc tggtgatcgg actgggctgc gaggtcaacc aggtcgaggg cctgaccggc      660

cgcctgccgt tgccggaagg ccgggtgcgc accatgacca tccaggacgc cggtggcacc      720

cgcgaggcca tcgcccaggg catcgatatc gtgcgcgaca tggcagcggc ggcatccggc      780

gcccggcgca ctcaggtgcc ggcatcgcac ctcgtggtgg ggctgcagtg cggcggatcg      840

gacggctact cgggcatcag cgccaacccg gtactgggcg cggcggtcga catgctggtg      900

cgccacggcg gcacggccat cctgtcggaa acacccgaga tctatggcgc cgagcatttg      960

ctgacggcgc gcgccgcatc ggccgaagtg gcagaacgcc tgatggcgcg cctggcctgg     1020

tgggaggcct acacccagcg caacggcgcg aacatgaaca acaacccctc gcccggcaac     1080

aaggccggcg gcatcaccac catcctcgag aaatcgctgg gcgcggtggc caagggcggt     1140

ggcagcgggc tgatggatgt ggtcgaatac gcgcagcccg tgcacagccg gggcctggtg     1200

ttcatggaca cccccggcta cgatccggtg tcggccaccg gccaggtcgc gggcggtgcc     1260

aacctcatct gtttcactac cgggcgggga tcgacctacg ggtgcaagcc cacgccgtcg     1320

ctcaagctcg ccaccaacac cgcgctgttc cgcaacatgg gcatggacat ggacttcaac     1380

gccggcgacg tggtggacgg aacgctgggc atcgcgcagg cgggccgcca tcttttcgaa     1440

ctgatgctcg ccacggcgtc cggcgaccgc acgctgagcg agacgcacgg tctgggcgac     1500

aacgaattcg tgccctggca gctcggcgcg gtgatgtga                            1539


<210>  151
<211>  512
<212>  PRT
<213>  Acidovorax avenae

<400>  151

Met Ser Thr Asp Ala Leu Ala Thr Gln Ser Leu Leu Ile Leu Asn Asp 
1               5                   10                  15      


Arg Asp Asn Val Ala Val Ala Arg Thr Glu Leu Gly Ala Gly Met Glu 
            20                  25                  30          


Leu Arg Leu Ala Gly Gly Glu Val Leu Glu Val Met Ala Thr Val Pro 
        35                  40                  45              


Ala Gly His Lys Ile Ala Leu Arg Pro Ile Ala Lys Gly Asp Ala Val 
    50                  55                  60                  


Leu Lys Tyr Gly Gln Val Ile Gly Ala Ala Ser Thr Pro Ile Gly Ala 
65                  70                  75                  80  


Gly Glu His Val His Val His Asn Val Glu Met Gly Asp Ser Ser Pro 
                85                  90                  95      


Thr His Leu Val Gly Arg Ala Tyr Val Pro Thr Asp Pro Val Glu Gln 
            100                 105                 110         


Pro Ala Thr Phe Met Gly Tyr Val Arg Ala Asp Gly Arg Val Gly Thr 
        115                 120                 125             


Arg Asn Tyr Ile Gly Val Ile Ser Ser Val Asn Cys Ser Ala Thr Val 
    130                 135                 140                 


Cys Lys Ala Ile Ala Gln Ala Phe Thr Gly Pro Ala Leu Gly Ala Tyr 
145                 150                 155                 160 


Pro Gly Val Asp Gly Val Val Ala Ile Thr His Gly Thr Gly Cys Gly 
                165                 170                 175     


Met Ser Gly Glu Gly Glu Gly Ile Glu Leu Leu Arg Arg Thr Leu Ser 
            180                 185                 190         


Gly Tyr Ile Ala His Pro Asn Phe Ala Ala Val Leu Val Ile Gly Leu 
        195                 200                 205             


Gly Cys Glu Val Asn Gln Val Glu Gly Leu Thr Gly Arg Leu Pro Leu 
    210                 215                 220                 


Pro Glu Gly Arg Val Arg Thr Met Thr Ile Gln Asp Ala Gly Gly Thr 
225                 230                 235                 240 


Arg Glu Ala Ile Ala Gln Gly Ile Asp Ile Val Arg Asp Met Ala Ala 
                245                 250                 255     


Ala Ala Ser Gly Ala Arg Arg Thr Gln Val Pro Ala Ser His Leu Val 
            260                 265                 270         


Val Gly Leu Gln Cys Gly Gly Ser Asp Gly Tyr Ser Gly Ile Ser Ala 
        275                 280                 285             


Asn Pro Val Leu Gly Ala Ala Val Asp Met Leu Val Arg His Gly Gly 
    290                 295                 300                 


Thr Ala Ile Leu Ser Glu Thr Pro Glu Ile Tyr Gly Ala Glu His Leu 
305                 310                 315                 320 


Leu Thr Ala Arg Ala Ala Ser Ala Glu Val Ala Glu Arg Leu Met Ala 
                325                 330                 335     


Arg Leu Ala Trp Trp Glu Ala Tyr Thr Gln Arg Asn Gly Ala Asn Met 
            340                 345                 350         


Asn Asn Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile Thr Thr Ile 
        355                 360                 365             


Leu Glu Lys Ser Leu Gly Ala Val Ala Lys Gly Gly Gly Ser Gly Leu 
    370                 375                 380                 


Met Asp Val Val Glu Tyr Ala Gln Pro Val His Ser Arg Gly Leu Val 
385                 390                 395                 400 


Phe Met Asp Thr Pro Gly Tyr Asp Pro Val Ser Ala Thr Gly Gln Val 
                405                 410                 415     


Ala Gly Gly Ala Asn Leu Ile Cys Phe Thr Thr Gly Arg Gly Ser Thr 
            420                 425                 430         


Tyr Gly Cys Lys Pro Thr Pro Ser Leu Lys Leu Ala Thr Asn Thr Ala 
        435                 440                 445             


Leu Phe Arg Asn Met Gly Met Asp Met Asp Phe Asn Ala Gly Asp Val 
    450                 455                 460                 


Val Asp Gly Thr Leu Gly Ile Ala Gln Ala Gly Arg His Leu Phe Glu 
465                 470                 475                 480 


Leu Met Leu Ala Thr Ala Ser Gly Asp Arg Thr Leu Ser Glu Thr His 
                485                 490                 495     


Gly Leu Gly Asp Asn Glu Phe Val Pro Trp Gln Leu Gly Ala Val Met 
            500                 505                 510         


<210>  152
<211>  1536
<212>  DNA
<213>  Herbaspirillum huttiense

<400>  152
atgaaagcca actctcccgt catccgcctg aacccggtcg atgatgtcgt catcgcccgc       60

cagcagctca tctccggcac cgtgctgcag gacgaaggcg gcctcaaagt ccagggcctc      120

attcccgccg gccacaagat ggcgacccgc gccatctctg cgggcgagcc ggtcaagcgc      180

tatggccaga tcatcggcac ggccagccag gacatcgcgc ccggacagca cgtgcacacg      240

cacaacctgg ccatggccga gttctcgcgt gaacaccatt tcggcgctga cgtgaagccg      300

gtcgatttcg tcgccgagcc cgcaaccttc atgggcatcg tgcgtcccga tggccgcgtg      360

gccacgcgca actacatcgg cgtactgacc tcggtgaact gctcggccac cgcggcacgc      420

gccatcgccg attacttccg ccgcgacatc catcccgaag tgctggccga ctatcccaac      480

atcgatggcg tggtggccct gacccatggc cagggttgcg ccacggattc gcagggcgag      540

ccgctgcaga tcctgcgccg cacgctggcg ggttacgcca cgcatcccaa cttcgctgcg      600

gtgctggtgg tgggcctggg ctgcgagacc aaccagatct cgggcctgat ggaaagccac      660

aacctgaagg aaggcgaata cttccacacc ttcaccatcc agggcaccgg cggcaccgcc      720

aagaccgtgg cgctggggat cgagaagatc aagaagatgc tgcccaaggc caatgacatc      780

aagcgcgagc cggtgtcggc caagcatctg acgctgggcc tgcagtgcgg tggttcggat      840

ggctattcgg gcatcacggc caatccggcg ctgggtgcgg cagtggactt gctggtgcgg      900

catggcggca cggccatcct ttccgaaacg ccggaaatct atggggccga acacctgctc      960

acccgccgcg cggtctcgcc ggaagtcggt gagaagctgc tggcccgcat cgcctggtgg     1020

gaggagtatt gcgccaagaa cgatgccgag atgaacaaca atccctcagc gggcaacaag     1080

gccggtggct tgaccaccat cctcgagaag tcgctgggcg cggttgccaa gggtggcact     1140

accaatctgg tggatgtcta caagtatgcg gagacggtca ccgcacgcgg cttcgtcttc     1200

atggatacgc cgggctacga cccgatctcc gccaccggcc aggtcgccgg aggggccaac     1260

atgatctgct tcaccacggg ccggggttct gcctatggct gcgcaccggc accgtcgctc     1320

aagctggcca ccaatactgc gctgtggcaa cgtcaggaag aagacatgga tatcaactgc     1380

ggcgagattg ccgacagcaa tgtcaccccg caggaggtcg gcgaacgctt cttccagatg     1440

atcctcgata cggcatcggg caagaagacc aagagcgagc tgcatggcta cgggcaagac     1500

gaattcgtgc cctggcacat cggcgtctac acctga                               1536


<210>  153
<211>  511
<212>  PRT
<213>  Herbaspirillum huttiense

<400>  153

Met Lys Ala Asn Ser Pro Val Ile Arg Leu Asn Pro Val Asp Asp Val 
1               5                   10                  15      


Val Ile Ala Arg Gln Gln Leu Ile Ser Gly Thr Val Leu Gln Asp Glu 
            20                  25                  30          


Gly Gly Leu Lys Val Gln Gly Leu Ile Pro Ala Gly His Lys Met Ala 
        35                  40                  45              


Thr Arg Ala Ile Ser Ala Gly Glu Pro Val Lys Arg Tyr Gly Gln Ile 
    50                  55                  60                  


Ile Gly Thr Ala Ser Gln Asp Ile Ala Pro Gly Gln His Val His Thr 
65                  70                  75                  80  


His Asn Leu Ala Met Ala Glu Phe Ser Arg Glu His His Phe Gly Ala 
                85                  90                  95      


Asp Val Lys Pro Val Asp Phe Val Ala Glu Pro Ala Thr Phe Met Gly 
            100                 105                 110         


Ile Val Arg Pro Asp Gly Arg Val Ala Thr Arg Asn Tyr Ile Gly Val 
        115                 120                 125             


Leu Thr Ser Val Asn Cys Ser Ala Thr Ala Ala Arg Ala Ile Ala Asp 
    130                 135                 140                 


Tyr Phe Arg Arg Asp Ile His Pro Glu Val Leu Ala Asp Tyr Pro Asn 
145                 150                 155                 160 


Ile Asp Gly Val Val Ala Leu Thr His Gly Gln Gly Cys Ala Thr Asp 
                165                 170                 175     


Ser Gln Gly Glu Pro Leu Gln Ile Leu Arg Arg Thr Leu Ala Gly Tyr 
            180                 185                 190         


Ala Thr His Pro Asn Phe Ala Ala Val Leu Val Val Gly Leu Gly Cys 
        195                 200                 205             


Glu Thr Asn Gln Ile Ser Gly Leu Met Glu Ser His Asn Leu Lys Glu 
    210                 215                 220                 


Gly Glu Tyr Phe His Thr Phe Thr Ile Gln Gly Thr Gly Gly Thr Ala 
225                 230                 235                 240 


Lys Thr Val Ala Leu Gly Ile Glu Lys Ile Lys Lys Met Leu Pro Lys 
                245                 250                 255     


Ala Asn Asp Ile Lys Arg Glu Pro Val Ser Ala Lys His Leu Thr Leu 
            260                 265                 270         


Gly Leu Gln Cys Gly Gly Ser Asp Gly Tyr Ser Gly Ile Thr Ala Asn 
        275                 280                 285             


Pro Ala Leu Gly Ala Ala Val Asp Leu Leu Val Arg His Gly Gly Thr 
    290                 295                 300                 


Ala Ile Leu Ser Glu Thr Pro Glu Ile Tyr Gly Ala Glu His Leu Leu 
305                 310                 315                 320 


Thr Arg Arg Ala Val Ser Pro Glu Val Gly Glu Lys Leu Leu Ala Arg 
                325                 330                 335     


Ile Ala Trp Trp Glu Glu Tyr Cys Ala Lys Asn Asp Ala Glu Met Asn 
            340                 345                 350         


Asn Asn Pro Ser Ala Gly Asn Lys Ala Gly Gly Leu Thr Thr Ile Leu 
        355                 360                 365             


Glu Lys Ser Leu Gly Ala Val Ala Lys Gly Gly Thr Thr Asn Leu Val 
    370                 375                 380                 


Asp Val Tyr Lys Tyr Ala Glu Thr Val Thr Ala Arg Gly Phe Val Phe 
385                 390                 395                 400 


Met Asp Thr Pro Gly Tyr Asp Pro Ile Ser Ala Thr Gly Gln Val Ala 
                405                 410                 415     


Gly Gly Ala Asn Met Ile Cys Phe Thr Thr Gly Arg Gly Ser Ala Tyr 
            420                 425                 430         


Gly Cys Ala Pro Ala Pro Ser Leu Lys Leu Ala Thr Asn Thr Ala Leu 
        435                 440                 445             


Trp Gln Arg Gln Glu Glu Asp Met Asp Ile Asn Cys Gly Glu Ile Ala 
    450                 455                 460                 


Asp Ser Asn Val Thr Pro Gln Glu Val Gly Glu Arg Phe Phe Gln Met 
465                 470                 475                 480 


Ile Leu Asp Thr Ala Ser Gly Lys Lys Thr Lys Ser Glu Leu His Gly 
                485                 490                 495     


Tyr Gly Gln Asp Glu Phe Val Pro Trp His Ile Gly Val Tyr Thr 
            500                 505                 510     


<210>  154
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Hh.araD

<400>  154
atgaaagcca actctcccgt catccgcctg aacccggtcg atgatgtcgt catcgcccgc       60

cagcagctca tctccggcac cgtgctgcag gacgaaggcg gcctcaaagt ccagggcctc      120

attcccgccg gccacaagat ggcgacccgc gccatctctg cgggcgagcc ggtcaagcgc      180

tatggccaga tcatcggcac ggccagccag gacatcgcgc ccggacagca cgtgcacacg      240

cacaacctgg ccatggccga gttctcgcgt gaacaccatt tcggcgctga cgtgaagccg      300

gtcgatttcg tcgccgagcc cgcaaccttc atgggcatcg tgcgtcccga tggccgcgtg      360

gccacgcgca actacatcgg cgtactgacc tcggtgaact gctcggccac cgcggcacgc      420

gccatcgccg attacttccg ccgcgacatc catcccgaag tgctggccga ctatcccaac      480

atcgatggcg tggtggccct gacccatggc cagggttgcg ccacggattc gcagggcgag      540

ccgctgcaga tcctgcgccg cacgctggcg ggttacgcca cgcatcccaa cttcgctgcg      600

gtgctggtgg tgggcctggg ctgcgagacc aaccagatct cgggcctgat ggaaagccac      660

aacctgaagg aaggcgaata cttccacacc ttcaccatcc agggcaccgg cggcaccgcc      720

aagaccgtgg cgctggggat cgagaagatc aagaagatgc tgcccaaggc caatgacatc      780

aagcgcgagc cggtgtcggc caagcatctg acgctgggcc tgcagtgcgg tggttcggat      840

ggctattcgg gcatcacggc caatccggcg ctgggtgcgg cagtggactt gctggtgcgg      900

catggcggca cggccatcct ttccgaaacg ccggaaatct atggggccga acacctgctc      960

acccgccgcg cggtctcgcc ggaagtcggt gagaagctgc tggcccgcat cgcctggtgg     1020

gaggagtatt gcgccaagaa cgatgccgag atgaacaaca atccctcagc gggcaacaag     1080

gccggtggct tgaccaccat cctcgagaag tcgctgggcg cggttgccaa gggtggcact     1140

accaatctgg tggatgtcta caagtatgcg gagacggtca ccgcacgcgg cttcgtcttc     1200

atggatacgc cgggctacga cccgatctcc gccaccggcc aggtcgccgg aggggccaac     1260

atgatctgct tcaccacggg ccggggttct gcctatggca gcgcaccggc accgtcgctc     1320

aagctggcca ccaatactgc gctgtggcaa cgtcaggaag aagacatgga tatcaactgc     1380

ggcgagattg ccgacagcaa tgtcaccccg caggaggtcg gcgaacgctt cttccagatg     1440

atcctcgata cggcatcggg caagaagacc aagagcgagc tgcatggcta cgggcaagac     1500

gaattcgtgc cctggcacat cggcgtctac acctga                               1536


<210>  155
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Hh.araD mit Mutation von Cystein zu Serin in Position
       434

<400>  155

Met Lys Ala Asn Ser Pro Val Ile Arg Leu Asn Pro Val Asp Asp Val 
1               5                   10                  15      


Val Ile Ala Arg Gln Gln Leu Ile Ser Gly Thr Val Leu Gln Asp Glu 
            20                  25                  30          


Gly Gly Leu Lys Val Gln Gly Leu Ile Pro Ala Gly His Lys Met Ala 
        35                  40                  45              


Thr Arg Ala Ile Ser Ala Gly Glu Pro Val Lys Arg Tyr Gly Gln Ile 
    50                  55                  60                  


Ile Gly Thr Ala Ser Gln Asp Ile Ala Pro Gly Gln His Val His Thr 
65                  70                  75                  80  


His Asn Leu Ala Met Ala Glu Phe Ser Arg Glu His His Phe Gly Ala 
                85                  90                  95      


Asp Val Lys Pro Val Asp Phe Val Ala Glu Pro Ala Thr Phe Met Gly 
            100                 105                 110         


Ile Val Arg Pro Asp Gly Arg Val Ala Thr Arg Asn Tyr Ile Gly Val 
        115                 120                 125             


Leu Thr Ser Val Asn Cys Ser Ala Thr Ala Ala Arg Ala Ile Ala Asp 
    130                 135                 140                 


Tyr Phe Arg Arg Asp Ile His Pro Glu Val Leu Ala Asp Tyr Pro Asn 
145                 150                 155                 160 


Ile Asp Gly Val Val Ala Leu Thr His Gly Gln Gly Cys Ala Thr Asp 
                165                 170                 175     


Ser Gln Gly Glu Pro Leu Gln Ile Leu Arg Arg Thr Leu Ala Gly Tyr 
            180                 185                 190         


Ala Thr His Pro Asn Phe Ala Ala Val Leu Val Val Gly Leu Gly Cys 
        195                 200                 205             


Glu Thr Asn Gln Ile Ser Gly Leu Met Glu Ser His Asn Leu Lys Glu 
    210                 215                 220                 


Gly Glu Tyr Phe His Thr Phe Thr Ile Gln Gly Thr Gly Gly Thr Ala 
225                 230                 235                 240 


Lys Thr Val Ala Leu Gly Ile Glu Lys Ile Lys Lys Met Leu Pro Lys 
                245                 250                 255     


Ala Asn Asp Ile Lys Arg Glu Pro Val Ser Ala Lys His Leu Thr Leu 
            260                 265                 270         


Gly Leu Gln Cys Gly Gly Ser Asp Gly Tyr Ser Gly Ile Thr Ala Asn 
        275                 280                 285             


Pro Ala Leu Gly Ala Ala Val Asp Leu Leu Val Arg His Gly Gly Thr 
    290                 295                 300                 


Ala Ile Leu Ser Glu Thr Pro Glu Ile Tyr Gly Ala Glu His Leu Leu 
305                 310                 315                 320 


Thr Arg Arg Ala Val Ser Pro Glu Val Gly Glu Lys Leu Leu Ala Arg 
                325                 330                 335     


Ile Ala Trp Trp Glu Glu Tyr Cys Ala Lys Asn Asp Ala Glu Met Asn 
            340                 345                 350         


Asn Asn Pro Ser Ala Gly Asn Lys Ala Gly Gly Leu Thr Thr Ile Leu 
        355                 360                 365             


Glu Lys Ser Leu Gly Ala Val Ala Lys Gly Gly Thr Thr Asn Leu Val 
    370                 375                 380                 


Asp Val Tyr Lys Tyr Ala Glu Thr Val Thr Ala Arg Gly Phe Val Phe 
385                 390                 395                 400 


Met Asp Thr Pro Gly Tyr Asp Pro Ile Ser Ala Thr Gly Gln Val Ala 
                405                 410                 415     


Gly Gly Ala Asn Met Ile Cys Phe Thr Thr Gly Arg Gly Ser Ala Tyr 
            420                 425                 430         


Gly Ser Ala Pro Ala Pro Ser Leu Lys Leu Ala Thr Asn Thr Ala Leu 
        435                 440                 445             


Trp Gln Arg Gln Glu Glu Asp Met Asp Ile Asn Cys Gly Glu Ile Ala 
    450                 455                 460                 


Asp Ser Asn Val Thr Pro Gln Glu Val Gly Glu Arg Phe Phe Gln Met 
465                 470                 475                 480 


Ile Leu Asp Thr Ala Ser Gly Lys Lys Thr Lys Ser Glu Leu His Gly 
                485                 490                 495     


Tyr Gly Gln Asp Glu Phe Val Pro Trp His Ile Gly Val Tyr Thr 
            500                 505                 510     


<210>  156
<211>  1479
<212>  DNA
<213>  Clostridium acetobutylicum

<400>  156
atgaaaaatg ttataaagat aaatgaaaaa gataatgttg tagttgcttt aaatgattta       60

aacaaaggcg atgtaattga aatagatgga aaagtaatta cagcagaaga gcctgtaaaa      120

aaaggtcata aaattgcaat tacagatata caaaagaact ctaatatata taagtatgga      180

tttcctattg gtcatgcgtt agaagaaata aaaaaaggtc aatgggtaca tactcataat      240

ataaaaacca atttggatgg aataaaggat tatgagtaca ataaacaaac ttttgagaat      300

ccatttaaaa atgaaaattt aacttttaag ggttatagaa gagaagacgg aacagtagga      360

ataagaaatg aattatggat agttccaact gttggttgtg tgaatggtac agctgattta      420

atagctgaaa gatttaaaag tgaaactgag tttaaagatg tacatgtatt taagcataat      480

tttggatgtt cacagcttgg tgatgatcac aataacacaa gaactatatt aggtaacatt      540

gtaaagcatc ctaatgcagg aggagtatta gttcttggac ttggttgcga aaataatact      600

atggagagtt tcaaggaatc acttcatagc tacaataaag aaagagtaag atttttaata      660

gctcaagatg tagaagatga aatatcttcc ggatgtgagt tgttaaaaga attatatgaa      720

aagatacaaa aggatgaaag agaagaggta tctatttcag aacttaaaat aggacttaaa      780

tgtggagcat cagatggttt ttctggaata actgcaaatc cacttttagg aaagttatca      840

gactttttaa tagcacaggg tggaacaact atacttacag aagttcctga aatgtttgga      900

gcagaaacaa tactcatgaa tagggcaaaa gatgagaaag tatttgcaaa aacggtaaac      960

ttgattaatg attttaaaaa atatttcatg agctataatc aacctgtata tgaaaatcct     1020

tctccaggaa acaaagcagg tggaataact acattagaag ataaatcatt aggatgtaca     1080

caaaaatcag gaagctctga agtagttgga gtacttaagt acggagaaac tttagaaaat     1140

aaagggttaa atcttttaag tgcgccaggt aatgatttag tggcatctac tgctcttgca     1200

tcggcaggat gtcatatggt gttgtttaca actggtagag gtacaccatt tggaactttt     1260

gtgccaactg ttaagatttc aactaactca gatatatata ataagaagaa aaattggata     1320

gattttaatg cgggtgcact tttagaaaat caatctatgg atcaagtgct taaagaattt     1380

attaattatt tactcggagt tgcaaacgga aatatggcaa acaatgagaa aaataacata     1440

agagaaatat ctatatttaa aaacggtgta acactataa                            1479


<210>  157
<211>  492
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  157

Met Lys Asn Val Ile Lys Ile Asn Glu Lys Asp Asn Val Val Val Ala 
1               5                   10                  15      


Leu Asn Asp Leu Asn Lys Gly Asp Val Ile Glu Ile Asp Gly Lys Val 
            20                  25                  30          


Ile Thr Ala Glu Glu Pro Val Lys Lys Gly His Lys Ile Ala Ile Thr 
        35                  40                  45              


Asp Ile Gln Lys Asn Ser Asn Ile Tyr Lys Tyr Gly Phe Pro Ile Gly 
    50                  55                  60                  


His Ala Leu Glu Glu Ile Lys Lys Gly Gln Trp Val His Thr His Asn 
65                  70                  75                  80  


Ile Lys Thr Asn Leu Asp Gly Ile Lys Asp Tyr Glu Tyr Asn Lys Gln 
                85                  90                  95      


Thr Phe Glu Asn Pro Phe Lys Asn Glu Asn Leu Thr Phe Lys Gly Tyr 
            100                 105                 110         


Arg Arg Glu Asp Gly Thr Val Gly Ile Arg Asn Glu Leu Trp Ile Val 
        115                 120                 125             


Pro Thr Val Gly Cys Val Asn Gly Thr Ala Asp Leu Ile Ala Glu Arg 
    130                 135                 140                 


Phe Lys Ser Glu Thr Glu Phe Lys Asp Val His Val Phe Lys His Asn 
145                 150                 155                 160 


Phe Gly Cys Ser Gln Leu Gly Asp Asp His Asn Asn Thr Arg Thr Ile 
                165                 170                 175     


Leu Gly Asn Ile Val Lys His Pro Asn Ala Gly Gly Val Leu Val Leu 
            180                 185                 190         


Gly Leu Gly Cys Glu Asn Asn Thr Met Glu Ser Phe Lys Glu Ser Leu 
        195                 200                 205             


His Ser Tyr Asn Lys Glu Arg Val Arg Phe Leu Ile Ala Gln Asp Val 
    210                 215                 220                 


Glu Asp Glu Ile Ser Ser Gly Cys Glu Leu Leu Lys Glu Leu Tyr Glu 
225                 230                 235                 240 


Lys Ile Gln Lys Asp Glu Arg Glu Glu Val Ser Ile Ser Glu Leu Lys 
                245                 250                 255     


Ile Gly Leu Lys Cys Gly Ala Ser Asp Gly Phe Ser Gly Ile Thr Ala 
            260                 265                 270         


Asn Pro Leu Leu Gly Lys Leu Ser Asp Phe Leu Ile Ala Gln Gly Gly 
        275                 280                 285             


Thr Thr Ile Leu Thr Glu Val Pro Glu Met Phe Gly Ala Glu Thr Ile 
    290                 295                 300                 


Leu Met Asn Arg Ala Lys Asp Glu Lys Val Phe Ala Lys Thr Val Asn 
305                 310                 315                 320 


Leu Ile Asn Asp Phe Lys Lys Tyr Phe Met Ser Tyr Asn Gln Pro Val 
                325                 330                 335     


Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile Thr Thr Leu 
            340                 345                 350         


Glu Asp Lys Ser Leu Gly Cys Thr Gln Lys Ser Gly Ser Ser Glu Val 
        355                 360                 365             


Val Gly Val Leu Lys Tyr Gly Glu Thr Leu Glu Asn Lys Gly Leu Asn 
    370                 375                 380                 


Leu Leu Ser Ala Pro Gly Asn Asp Leu Val Ala Ser Thr Ala Leu Ala 
385                 390                 395                 400 


Ser Ala Gly Cys His Met Val Leu Phe Thr Thr Gly Arg Gly Thr Pro 
                405                 410                 415     


Phe Gly Thr Phe Val Pro Thr Val Lys Ile Ser Thr Asn Ser Asp Ile 
            420                 425                 430         


Tyr Asn Lys Lys Lys Asn Trp Ile Asp Phe Asn Ala Gly Ala Leu Leu 
        435                 440                 445             


Glu Asn Gln Ser Met Asp Gln Val Leu Lys Glu Phe Ile Asn Tyr Leu 
    450                 455                 460                 


Leu Gly Val Ala Asn Gly Asn Met Ala Asn Asn Glu Lys Asn Asn Ile 
465                 470                 475                 480 


Arg Glu Ile Ser Ile Phe Lys Asn Gly Val Thr Leu 
                485                 490         


<210>  158
<211>  1530
<212>  DNA
<213>  Paraburkholderia mimosarum

<400>  158
atgaagacct caacagcaga cgcagatgtc accgtgcgac tgcatcccga tgacgatgtg       60

atcatcgcgc tgcagcagct tgtgggtggc acaacggtgg acggtggccg cgtaaccgtc      120

cgggggctgg tggcccctgg tcacaaggtc gcctcacgtg ccatccagca aggcgagccg      180

gttcgacggt acgggcagat catcggcttt gcctcgtgcg acatcggctg cggcgaccac      240

gtccacacgc ataacctgtc gatgggcagc ttcgaccgcg actatgcgtt tggaaaggac      300

gcaaagccag cgcccgtcgc gagccgtgcg agcttcatgg gtatcgtccg tcctgatgga      360

cgcgtcgcga cgcgcaatta catcggcatt cttacgtcag tgaactgctc tgcgaccgtc      420

gcacgtgcca ttgcagacca cttcaaacct gaagtgctac gcgactatcc aaacgtggac      480

ggggtcgtcg cactcacgca tggccagggt tgcgcgatcg actcacaagg agaaggcctg      540

gcactgatcc gtcgaacgct cggtgggtac gcacgacatc ctaatttcgc ggcggtgctc      600

atcgtcggac tcgggtgcga gaccaaccag attgggggcc tgctcgaaag tcagggtctt      660

gaggcgggca gcacgctgaa ggtcatgacc attcaggcta ccggtggcac gtcgcgcaca      720

gtggcggctg gcatcgacgc tgtgcaggcg ctgctgccag aggccaatcg cgtgaagcgg      780

gaggcagtcg acgcaagtaa tctcgtggtt ggtttgcagt gcggcgggtc cgacggctat      840

tcgggtatct cggcgaatcc ggcgcttggt gctgcggtcg accgtcttgt tgcccacggc      900

ggcgttgcca ttctgtccga gacaccggaa atatacggcg cggagcacct gctcacccgc      960

cgcgccattt cacgcgcggt cggagaaaag ctgatcgagc gcattcactg gtgggaaact     1020

tattgtgcac gcatgggcgc agacctgaat aacaacccgt cggcgggtaa taaggcaggt     1080

ggcctgacga caattctcga gaagtcgttg ggcgctgtgg ccaaaggcgg cacgacgaac     1140

ctgattgctg tttatcgcta tgcggagccg gtatcggcac acggtctggt tttcatggac     1200

accccgggct atgaccccgt ctcggcaacc ggccaggtag caggcggagc caacctgatc     1260

tgctttacaa cggggcgcgg ctctgcatac ggctgcgcgc cttcgccctc gctgaaactg     1320

ggcaccaaca gcgaactatg gcgcagacag gaagaagata tcgacctgaa ctgcggagag     1380

atcctcgacg gaacgaggag cgtcgacgaa atgggccagg agattttcga gctcatgctg     1440

gcaaccgcat cgggtatgcg atcaaagagt gagcttcacg gctacggaca aaatgagttc     1500

gtaccctggc agatcggcgc gatcacctga                                      1530


<210>  159
<211>  509
<212>  PRT
<213>  Paraburkholderia mimosarum

<400>  159

Met Lys Thr Ser Thr Ala Asp Ala Asp Val Thr Val Arg Leu His Pro 
1               5                   10                  15      


Asp Asp Asp Val Ile Ile Ala Leu Gln Gln Leu Val Gly Gly Thr Thr 
            20                  25                  30          


Val Asp Gly Gly Arg Val Thr Val Arg Gly Leu Val Ala Pro Gly His 
        35                  40                  45              


Lys Val Ala Ser Arg Ala Ile Gln Gln Gly Glu Pro Val Arg Arg Tyr 
    50                  55                  60                  


Gly Gln Ile Ile Gly Phe Ala Ser Cys Asp Ile Gly Cys Gly Asp His 
65                  70                  75                  80  


Val His Thr His Asn Leu Ser Met Gly Ser Phe Asp Arg Asp Tyr Ala 
                85                  90                  95      


Phe Gly Lys Asp Ala Lys Pro Ala Pro Val Ala Ser Arg Ala Ser Phe 
            100                 105                 110         


Met Gly Ile Val Arg Pro Asp Gly Arg Val Ala Thr Arg Asn Tyr Ile 
        115                 120                 125             


Gly Ile Leu Thr Ser Val Asn Cys Ser Ala Thr Val Ala Arg Ala Ile 
    130                 135                 140                 


Ala Asp His Phe Lys Pro Glu Val Leu Arg Asp Tyr Pro Asn Val Asp 
145                 150                 155                 160 


Gly Val Val Ala Leu Thr His Gly Gln Gly Cys Ala Ile Asp Ser Gln 
                165                 170                 175     


Gly Glu Gly Leu Ala Leu Ile Arg Arg Thr Leu Gly Gly Tyr Ala Arg 
            180                 185                 190         


His Pro Asn Phe Ala Ala Val Leu Ile Val Gly Leu Gly Cys Glu Thr 
        195                 200                 205             


Asn Gln Ile Gly Gly Leu Leu Glu Ser Gln Gly Leu Glu Ala Gly Ser 
    210                 215                 220                 


Thr Leu Lys Val Met Thr Ile Gln Ala Thr Gly Gly Thr Ser Arg Thr 
225                 230                 235                 240 


Val Ala Ala Gly Ile Asp Ala Val Gln Ala Leu Leu Pro Glu Ala Asn 
                245                 250                 255     


Arg Val Lys Arg Glu Ala Val Asp Ala Ser Asn Leu Val Val Gly Leu 
            260                 265                 270         


Gln Cys Gly Gly Ser Asp Gly Tyr Ser Gly Ile Ser Ala Asn Pro Ala 
        275                 280                 285             


Leu Gly Ala Ala Val Asp Arg Leu Val Ala His Gly Gly Val Ala Ile 
    290                 295                 300                 


Leu Ser Glu Thr Pro Glu Ile Tyr Gly Ala Glu His Leu Leu Thr Arg 
305                 310                 315                 320 


Arg Ala Ile Ser Arg Ala Val Gly Glu Lys Leu Ile Glu Arg Ile His 
                325                 330                 335     


Trp Trp Glu Thr Tyr Cys Ala Arg Met Gly Ala Asp Leu Asn Asn Asn 
            340                 345                 350         


Pro Ser Ala Gly Asn Lys Ala Gly Gly Leu Thr Thr Ile Leu Glu Lys 
        355                 360                 365             


Ser Leu Gly Ala Val Ala Lys Gly Gly Thr Thr Asn Leu Ile Ala Val 
    370                 375                 380                 


Tyr Arg Tyr Ala Glu Pro Val Ser Ala His Gly Leu Val Phe Met Asp 
385                 390                 395                 400 


Thr Pro Gly Tyr Asp Pro Val Ser Ala Thr Gly Gln Val Ala Gly Gly 
                405                 410                 415     


Ala Asn Leu Ile Cys Phe Thr Thr Gly Arg Gly Ser Ala Tyr Gly Cys 
            420                 425                 430         


Ala Pro Ser Pro Ser Leu Lys Leu Gly Thr Asn Ser Glu Leu Trp Arg 
        435                 440                 445             


Arg Gln Glu Glu Asp Ile Asp Leu Asn Cys Gly Glu Ile Leu Asp Gly 
    450                 455                 460                 


Thr Arg Ser Val Asp Glu Met Gly Gln Glu Ile Phe Glu Leu Met Leu 
465                 470                 475                 480 


Ala Thr Ala Ser Gly Met Arg Ser Lys Ser Glu Leu His Gly Tyr Gly 
                485                 490                 495     


Gln Asn Glu Phe Val Pro Trp Gln Ile Gly Ala Ile Thr 
            500                 505                 


<210>  160
<211>  1488
<212>  DNA
<213>  Escherichia coli

<400>  160
atgcaataca tcaagatcca tgcgctggat aacgtcgcgg tcgctttagc agatttggct       60

gaaggcacag aagtcagtgt cgataaccag actgttacgc tgcgccagga tgttgctcgt      120

ggacataaat ttgcgttaac ggatatcgca aaaggggcca atgtcatcaa atatggcctg      180

ccgattggtt atgcattggc ggatattgcg gcaggtgttc acgttcacgc ccacaatacg      240

cgcacgaatc tgagcgatct ggatcagtat cgctatcaac ctgattttca ggatctgcct      300

gcgcaagcgg cagatcgtga agtgcagatc tatcgtcgcg ctaacggcga tgtcggggtg      360

cgtaatgagc tgtggatcct gccaaccgtg ggctgtgtca acggcatcgc gcggcagatc      420

cagaaccgtt ttctgaaaga gaccaacaac gccgaaggta ctgacggcgt gttcctcttc      480

agccacacct acggctgctc acagctgggc gacgatcaca ttaatacccg caccatgctg      540

caaaacatgg tgcgccaccc gaacgcaggc gcagtgctgg tgattggtct gggctgtgaa      600

aacaaccagg ttgccgcatt ccgtgaaacg ctgggcgata tcgatcctga acgcgttcat      660

ttcatgatct gccaacagca ggatgatgag atcgaagccg gaatcgagca tttgcatcag      720

ctgtataacg tgatgcgcaa cgataaacgc gagccaggca aactcagcga actgaagttt      780

ggtctggagt gcggtggttc tgacggtctt tctggtatta ctgctaaccc gatgctgggg      840

cgtttctctg actacgtgat tgctaacggc ggtactaccg tactgaccga agtgccggag      900

atgtttggcg cagagcagtt gctgatggac cattgccgcg acgaagcaac gtttgaaaaa      960

ctggtcacca tggtcaacga cttcaaacag tactttattg cccatgatca gccgatctat     1020

gaaaacccat cgccggggaa caaagcgggc ggtatcacca cgctggaaga caaatcactt     1080

ggctgtaccc agaaagcggg ttccagcgtc gtggttgacg tgctgcgtta cggcgagcgt     1140

ctgaaaacgc cagggctgaa cttgttaagt gcgccgggta acgatgccgt agcgaccagc     1200

gccctggcgg gtgcgggctg ccatatggtg ctgttcagta ctggtcgtgg cacgccgtat     1260

ggtggatttg tgccgacggt gaaaatcgcc accaacagtg aactggcggc gaagaaaaaa     1320

cactggatcg actttgacgc gggtcagttg atccacggta aagcgatgcc gcagttgctg     1380

gaagaattta tcgacaccat cgttgagttt gccaacggta agcaaacctg taacgagcgt     1440

aacgacttcc gcgaactggc gatcttcaaa agcggcgtaa cgctataa                  1488


<210>  161
<211>  495
<212>  PRT
<213>  Escherichia coli

<400>  161

Met Gln Tyr Ile Lys Ile His Ala Leu Asp Asn Val Ala Val Ala Leu 
1               5                   10                  15      


Ala Asp Leu Ala Glu Gly Thr Glu Val Ser Val Asp Asn Gln Thr Val 
            20                  25                  30          


Thr Leu Arg Gln Asp Val Ala Arg Gly His Lys Phe Ala Leu Thr Asp 
        35                  40                  45              


Ile Ala Lys Gly Ala Asn Val Ile Lys Tyr Gly Leu Pro Ile Gly Tyr 
    50                  55                  60                  


Ala Leu Ala Asp Ile Ala Ala Gly Val His Val His Ala His Asn Thr 
65                  70                  75                  80  


Arg Thr Asn Leu Ser Asp Leu Asp Gln Tyr Arg Tyr Gln Pro Asp Phe 
                85                  90                  95      


Gln Asp Leu Pro Ala Gln Ala Ala Asp Arg Glu Val Gln Ile Tyr Arg 
            100                 105                 110         


Arg Ala Asn Gly Asp Val Gly Val Arg Asn Glu Leu Trp Ile Leu Pro 
        115                 120                 125             


Thr Val Gly Cys Val Asn Gly Ile Ala Arg Gln Ile Gln Asn Arg Phe 
    130                 135                 140                 


Leu Lys Glu Thr Asn Asn Ala Glu Gly Thr Asp Gly Val Phe Leu Phe 
145                 150                 155                 160 


Ser His Thr Tyr Gly Cys Ser Gln Leu Gly Asp Asp His Ile Asn Thr 
                165                 170                 175     


Arg Thr Met Leu Gln Asn Met Val Arg His Pro Asn Ala Gly Ala Val 
            180                 185                 190         


Leu Val Ile Gly Leu Gly Cys Glu Asn Asn Gln Val Ala Ala Phe Arg 
        195                 200                 205             


Glu Thr Leu Gly Asp Ile Asp Pro Glu Arg Val His Phe Met Ile Cys 
    210                 215                 220                 


Gln Gln Gln Asp Asp Glu Ile Glu Ala Gly Ile Glu His Leu His Gln 
225                 230                 235                 240 


Leu Tyr Asn Val Met Arg Asn Asp Lys Arg Glu Pro Gly Lys Leu Ser 
                245                 250                 255     


Glu Leu Lys Phe Gly Leu Glu Cys Gly Gly Ser Asp Gly Leu Ser Gly 
            260                 265                 270         


Ile Thr Ala Asn Pro Met Leu Gly Arg Phe Ser Asp Tyr Val Ile Ala 
        275                 280                 285             


Asn Gly Gly Thr Thr Val Leu Thr Glu Val Pro Glu Met Phe Gly Ala 
    290                 295                 300                 


Glu Gln Leu Leu Met Asp His Cys Arg Asp Glu Ala Thr Phe Glu Lys 
305                 310                 315                 320 


Leu Val Thr Met Val Asn Asp Phe Lys Gln Tyr Phe Ile Ala His Asp 
                325                 330                 335     


Gln Pro Ile Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile 
            340                 345                 350         


Thr Thr Leu Glu Asp Lys Ser Leu Gly Cys Thr Gln Lys Ala Gly Ser 
        355                 360                 365             


Ser Val Val Val Asp Val Leu Arg Tyr Gly Glu Arg Leu Lys Thr Pro 
    370                 375                 380                 


Gly Leu Asn Leu Leu Ser Ala Pro Gly Asn Asp Ala Val Ala Thr Ser 
385                 390                 395                 400 


Ala Leu Ala Gly Ala Gly Cys His Met Val Leu Phe Ser Thr Gly Arg 
                405                 410                 415     


Gly Thr Pro Tyr Gly Gly Phe Val Pro Thr Val Lys Ile Ala Thr Asn 
            420                 425                 430         


Ser Glu Leu Ala Ala Lys Lys Lys His Trp Ile Asp Phe Asp Ala Gly 
        435                 440                 445             


Gln Leu Ile His Gly Lys Ala Met Pro Gln Leu Leu Glu Glu Phe Ile 
    450                 455                 460                 


Asp Thr Ile Val Glu Phe Ala Asn Gly Lys Gln Thr Cys Asn Glu Arg 
465                 470                 475                 480 


Asn Asp Phe Arg Glu Leu Ala Ile Phe Lys Ser Gly Val Thr Leu 
                485                 490                 495 


<210>  162
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Ec.Mdh

<400>  162
atgaaagtcg cagtcctcgg cgccgctggc ggtgtcggcc aggcgcttgc actactgtta       60

aaaacccaac tgccttcagg ttcagaactc tctctgtatg atatcgctcc agtgactccc      120

ggtgtggctg tcgatctgag ccatatccct actgctgtga aaatcaaagg tttttctggt      180

gaagatgcga ctccggcgct ggaaggcgca gatgtcgttc ttatctctgc aggcgtagcg      240

gctaaaccgg gccagtctcg ttccgacctg tttaacgtta acgccggcat cgtgaaaaac      300

ctggtacagc aagttgcgaa aacctgcccg aaagcgtgca ttggtattat cactaacccg      360

gttaacacca cagttgcaat tgctgctgaa gtgctgaaaa aagccggtgt ttatgacaaa      420

aacaaactgt tcggcgttac cacgctggat atcattcgtt ccaacacctt tgttgcggaa      480

ctgaaaggca aacagccagg cgaagttgaa gtgccggtta ttggcggcca ctctgatgtt      540

accattctgc cgctgctgtc acaggttcct ggcgttagtt ttaccgagca ggaagtggct      600

gatctgacca aacgcatcca gaacgcgggt actgaagtgg ttgaagcgaa ggccggtggc      660

gggtctgcaa ccctgtctat gggccaggca gctgcacgtt ttggtctgtc tctggttcgt      720

gcactgcagg gcgaacaagg cgttgtcgaa tgtgcctacg ttgaaggcga cggtcagtac      780

gcccgtttct tctctcaacc gctgctgctg ggtaaaaacg gcgtggaaga gcgtaaatct      840

atcggtaccc tgagcgcatt tgaacagaac gcgctggaag gtatgctgga tacgctgaag      900

aaagatatcg ccctgggcga agagttcgtt aataagtaa                             939


<210>  163
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Ec.Mdh mit den Mutationen I12V R81A M85Q D86S G179D

<400>  163

Met Lys Val Ala Val Leu Gly Ala Ala Gly Gly Val Gly Gln Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Lys Thr Gln Leu Pro Ser Gly Ser Glu Leu Ser Leu 
            20                  25                  30          


Tyr Asp Ile Ala Pro Val Thr Pro Gly Val Ala Val Asp Leu Ser His 
        35                  40                  45              


Ile Pro Thr Ala Val Lys Ile Lys Gly Phe Ser Gly Glu Asp Ala Thr 
    50                  55                  60                  


Pro Ala Leu Glu Gly Ala Asp Val Val Leu Ile Ser Ala Gly Val Ala 
65                  70                  75                  80  


Ala Lys Pro Gly Gln Ser Arg Ser Asp Leu Phe Asn Val Asn Ala Gly 
                85                  90                  95      


Ile Val Lys Asn Leu Val Gln Gln Val Ala Lys Thr Cys Pro Lys Ala 
            100                 105                 110         


Cys Ile Gly Ile Ile Thr Asn Pro Val Asn Thr Thr Val Ala Ile Ala 
        115                 120                 125             


Ala Glu Val Leu Lys Lys Ala Gly Val Tyr Asp Lys Asn Lys Leu Phe 
    130                 135                 140                 


Gly Val Thr Thr Leu Asp Ile Ile Arg Ser Asn Thr Phe Val Ala Glu 
145                 150                 155                 160 


Leu Lys Gly Lys Gln Pro Gly Glu Val Glu Val Pro Val Ile Gly Gly 
                165                 170                 175     


His Ser Asp Val Thr Ile Leu Pro Leu Leu Ser Gln Val Pro Gly Val 
            180                 185                 190         


Ser Phe Thr Glu Gln Glu Val Ala Asp Leu Thr Lys Arg Ile Gln Asn 
        195                 200                 205             


Ala Gly Thr Glu Val Val Glu Ala Lys Ala Gly Gly Gly Ser Ala Thr 
    210                 215                 220                 


Leu Ser Met Gly Gln Ala Ala Ala Arg Phe Gly Leu Ser Leu Val Arg 
225                 230                 235                 240 


Ala Leu Gln Gly Glu Gln Gly Val Val Glu Cys Ala Tyr Val Glu Gly 
                245                 250                 255     


Asp Gly Gln Tyr Ala Arg Phe Phe Ser Gln Pro Leu Leu Leu Gly Lys 
            260                 265                 270         


Asn Gly Val Glu Glu Arg Lys Ser Ile Gly Thr Leu Ser Ala Phe Glu 
        275                 280                 285             


Gln Asn Ala Leu Glu Gly Met Leu Asp Thr Leu Lys Lys Asp Ile Ala 
    290                 295                 300                 


Leu Gly Glu Glu Phe Val Asn Lys 
305                 310         


<210>  164
<211>  984
<212>  DNA
<213>  Cupriavidus necator

<400>  164
atgcagattt ctatcaaacg cgccatcgag cgcgtgcccg gcggcatgat gatcgtgccg       60

ctgctgatcg gttcgctcgt tgccacgttc gcgccggatg ggccgaagtt ttttggatcg      120

tttaccggcg cgctttttac cggtgccctg cccatcctcg cggtgttcta tgtctgcatg      180

ggggcaagca tcaacatcaa agccacgcct tacattctca agaagggcgg cgtgttgttc      240

ggcaccaagg tcggcacggc aatggtgttg ggcgtgatca tggggcactt cctgggcgag      300

gcgccgatca gtgccgggat gtttgccggc ctgtcgacgc ttgccgtggt ggccgcgatg      360

aacgacacca acggcggcct gtacatggcg ctgatgggcc agtacggcaa gcctgaagac      420

gtgggcgcct acagcatcat gtcgctcgag tccggcccgt tcctgacgat ggtgacgctg      480

ggcgtggcgg gtttgtccgc gttcccatgg ccgacgatgg tcggcagcat tcttccgctc      540

atgctcggca tgttgctggg caacctggat cgggagatgc gcgatttcct gggtaaggcc      600

gtgccggtca tgattccctt tttcgcactg gcgctgggcg caggcctgga cctgcacaag      660

gtctggcagg cgggcatgct gggcctcggc cttggtgttg ccgtggtggc cgtcaccggc      720

tgcgcgctgt acttcgctga ccgcctcacc ggcggcacgg gtgtggcagg tgtcgcagcc      780

gccagcaccg ccggcaatgc cgccgccgtg ccgacgctgg tagcggcggc taatccggtc      840

tacgcagaat cggccaagag cgccacgatc ctggtggccg cctgcgtggt ggtcaccgcc      900

gtactgacgc cattggtgac cgcctggatt gcccgccgcg tggcgggcaa ggaggccgag      960

gcgttggtga ggaccgccgc atga                                             984


<210>  165
<211>  327
<212>  PRT
<213>  Cupriavidus necator

<400>  165

Met Gln Ile Ser Ile Lys Arg Ala Ile Glu Arg Val Pro Gly Gly Met 
1               5                   10                  15      


Met Ile Val Pro Leu Leu Ile Gly Ser Leu Val Ala Thr Phe Ala Pro 
            20                  25                  30          


Asp Gly Pro Lys Phe Phe Gly Ser Phe Thr Gly Ala Leu Phe Thr Gly 
        35                  40                  45              


Ala Leu Pro Ile Leu Ala Val Phe Tyr Val Cys Met Gly Ala Ser Ile 
    50                  55                  60                  


Asn Ile Lys Ala Thr Pro Tyr Ile Leu Lys Lys Gly Gly Val Leu Phe 
65                  70                  75                  80  


Gly Thr Lys Val Gly Thr Ala Met Val Leu Gly Val Ile Met Gly His 
                85                  90                  95      


Phe Leu Gly Glu Ala Pro Ile Ser Ala Gly Met Phe Ala Gly Leu Ser 
            100                 105                 110         


Thr Leu Ala Val Val Ala Ala Met Asn Asp Thr Asn Gly Gly Leu Tyr 
        115                 120                 125             


Met Ala Leu Met Gly Gln Tyr Gly Lys Pro Glu Asp Val Gly Ala Tyr 
    130                 135                 140                 


Ser Ile Met Ser Leu Glu Ser Gly Pro Phe Leu Thr Met Val Thr Leu 
145                 150                 155                 160 


Gly Val Ala Gly Leu Ser Ala Phe Pro Trp Pro Thr Met Val Gly Ser 
                165                 170                 175     


Ile Leu Pro Leu Met Leu Gly Met Leu Leu Gly Asn Leu Asp Arg Glu 
            180                 185                 190         


Met Arg Asp Phe Leu Gly Lys Ala Val Pro Val Met Ile Pro Phe Phe 
        195                 200                 205             


Ala Leu Ala Leu Gly Ala Gly Leu Asp Leu His Lys Val Trp Gln Ala 
    210                 215                 220                 


Gly Met Leu Gly Leu Gly Leu Gly Val Ala Val Val Ala Val Thr Gly 
225                 230                 235                 240 


Cys Ala Leu Tyr Phe Ala Asp Arg Leu Thr Gly Gly Thr Gly Val Ala 
                245                 250                 255     


Gly Val Ala Ala Ala Ser Thr Ala Gly Asn Ala Ala Ala Val Pro Thr 
            260                 265                 270         


Leu Val Ala Ala Ala Asn Pro Val Tyr Ala Glu Ser Ala Lys Ser Ala 
        275                 280                 285             


Thr Ile Leu Val Ala Ala Cys Val Val Val Thr Ala Val Leu Thr Pro 
    290                 295                 300                 


Leu Val Thr Ala Trp Ile Ala Arg Arg Val Ala Gly Lys Glu Ala Glu 
305                 310                 315                 320 


Ala Leu Val Arg Thr Ala Ala 
                325         


<210>  166
<211>  1191
<212>  DNA
<213>  Escherichia coli

<400>  166
atgtttgaga acattaccgc cgctcctgcc gacccgattc tgggcctggc cgatctgttt       60

cgtgccgatg aacgtcccgg caaaattaac ctcgggattg gtgtctataa agatgagacg      120

ggcaaaaccc cggtactgac cagcgtgaaa aaggctgaac agtatctgct cgaaaatgaa      180

accaccaaaa attacctcgg cattgacggc atccctgaat ttggtcgctg cactcaggaa      240

ctgctgtttg gtaaaggtag cgccctgatc aatgacaaac gtgctcgcac ggcacagact      300

ccggggggca ctggcgcact acgcgtggct gccgatttcc tggcaaaaaa taccagcgtt      360

aagcgtgtgt gggtgagcaa cccaagctgg ccgaaccata agagcgtctt taactctgca      420

ggtctggaag ttcgtgaata cgcttattat gatgcggaaa atcacactct tgacttcgat      480

gcactgatta acagcctgaa tgaagctcag gctggcgacg tagtgctgtt ccatggctgc      540

tgccataacc caaccggtat cgaccctacg ctggaacaat ggcaaacact ggcacaactc      600

tccgttgaga aaggctggtt accgctgttt gacttcgctt accagggttt tgcccgtggt      660

ctggaagaag atgctgaagg actgcgcgct ttcgcggcta tgcataaaga gctgattgtt      720

gccagttcct actctaaaaa ctttggcctg tacaacgagc gtgttggcgc ttgtactctg      780

gttgctgccg acagtgaaac cgttgatcgc gcattcagcc aaatgaaagc ggcgattcgc      840

gctaactact ctaacccacc agcacacggc gcttctgttg ttgccaccat cctgagcaac      900

gatgcgttac gtgcgatttg ggaacaagag ctgactgata tgcgccagcg tattcagcgt      960

atgcgtcagt tgttcgtcaa tacgctgcag gaaaaaggcg caaaccgcga cttcagcttt     1020

atcatcaaac agaacggcat gttctccttc agtggcctga caaaagaaca agtgctgcgt     1080

ctgcgcgaag agtttggcgt atatgcggtt gcttctggtc gcgtaaatgt ggccgggatg     1140

acaccagata acatggctcc gctgtgcgaa gcgattgtgg cagtgctgta a              1191


<210>  167
<211>  396
<212>  PRT
<213>  Escherichia coli

<400>  167

Met Phe Glu Asn Ile Thr Ala Ala Pro Ala Asp Pro Ile Leu Gly Leu 
1               5                   10                  15      


Ala Asp Leu Phe Arg Ala Asp Glu Arg Pro Gly Lys Ile Asn Leu Gly 
            20                  25                  30          


Ile Gly Val Tyr Lys Asp Glu Thr Gly Lys Thr Pro Val Leu Thr Ser 
        35                  40                  45              


Val Lys Lys Ala Glu Gln Tyr Leu Leu Glu Asn Glu Thr Thr Lys Asn 
    50                  55                  60                  


Tyr Leu Gly Ile Asp Gly Ile Pro Glu Phe Gly Arg Cys Thr Gln Glu 
65                  70                  75                  80  


Leu Leu Phe Gly Lys Gly Ser Ala Leu Ile Asn Asp Lys Arg Ala Arg 
                85                  90                  95      


Thr Ala Gln Thr Pro Gly Gly Thr Gly Ala Leu Arg Val Ala Ala Asp 
            100                 105                 110         


Phe Leu Ala Lys Asn Thr Ser Val Lys Arg Val Trp Val Ser Asn Pro 
        115                 120                 125             


Ser Trp Pro Asn His Lys Ser Val Phe Asn Ser Ala Gly Leu Glu Val 
    130                 135                 140                 


Arg Glu Tyr Ala Tyr Tyr Asp Ala Glu Asn His Thr Leu Asp Phe Asp 
145                 150                 155                 160 


Ala Leu Ile Asn Ser Leu Asn Glu Ala Gln Ala Gly Asp Val Val Leu 
                165                 170                 175     


Phe His Gly Cys Cys His Asn Pro Thr Gly Ile Asp Pro Thr Leu Glu 
            180                 185                 190         


Gln Trp Gln Thr Leu Ala Gln Leu Ser Val Glu Lys Gly Trp Leu Pro 
        195                 200                 205             


Leu Phe Asp Phe Ala Tyr Gln Gly Phe Ala Arg Gly Leu Glu Glu Asp 
    210                 215                 220                 


Ala Glu Gly Leu Arg Ala Phe Ala Ala Met His Lys Glu Leu Ile Val 
225                 230                 235                 240 


Ala Ser Ser Tyr Ser Lys Asn Phe Gly Leu Tyr Asn Glu Arg Val Gly 
                245                 250                 255     


Ala Cys Thr Leu Val Ala Ala Asp Ser Glu Thr Val Asp Arg Ala Phe 
            260                 265                 270         


Ser Gln Met Lys Ala Ala Ile Arg Ala Asn Tyr Ser Asn Pro Pro Ala 
        275                 280                 285             


His Gly Ala Ser Val Val Ala Thr Ile Leu Ser Asn Asp Ala Leu Arg 
    290                 295                 300                 


Ala Ile Trp Glu Gln Glu Leu Thr Asp Met Arg Gln Arg Ile Gln Arg 
305                 310                 315                 320 


Met Arg Gln Leu Phe Val Asn Thr Leu Gln Glu Lys Gly Ala Asn Arg 
                325                 330                 335     


Asp Phe Ser Phe Ile Ile Lys Gln Asn Gly Met Phe Ser Phe Ser Gly 
            340                 345                 350         


Leu Thr Lys Glu Gln Val Leu Arg Leu Arg Glu Glu Phe Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Ser Gly Arg Val Asn Val Ala Gly Met Thr Pro Asp Asn 
    370                 375                 380                 


Met Ala Pro Leu Cys Glu Ala Ile Val Ala Val Leu 
385                 390                 395     


<210>  168
<211>  7978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Plasmid

<400>  168
ggatccgttt aactttaaga aggagatata ccatggaact gtatctggat acttcagacg       60

ttgttgcggt gaaggcgctg tcacgtattt ttccgctggc gggtgtgacc actaacccaa      120

gcattatcgc cgcgggtaaa aaaccgctgg atgttgtgct tccgcaactt catgaagcga      180

tgggcggtca ggggcgtctg tttgcccagg taatggctac cactgccgaa gggatggtta      240

atgacgcgct taagctgcgt tctattattg cggatatcgt ggtgaaagtt ccggtgaccg      300

ccgaggggct ggcagctatt aagatgttaa aagcggaagg gattccgacg tatggaaccg      360

cggtatatgg cgcagcacaa gggctgctgt cggcgctggc aggtgcggaa tatgttggcc      420

cttacgttaa tcgtattgat gctcagggcg gtagcggcat tcagactgtg accgacttac      480

accagttatt gaaaatgcat gcgccgcagg cgaaagtgct ggcagcgagt ttcaaaaccc      540

cgcgtcaggc gctggactgc ttactggcag gatgtgaatc aattactctg ccactggatg      600

tggcacaaca gatgattagc tatccggcgg ttgatgccgc tgtggcgaag tttgagcagg      660

actggcaggg agcgtttggc agaacgtcga tttaaatgtt taactttaag aaggagatat      720

accatgtcta ccgatagttt acaacagttt cgtcgccgtg tggcaattcc gggtccggct      780

ggttttggtg cagcaccgct gggcaatctg tttagccgtg ttaccgatga ggccgcacaa      840

gaaactttaa gtgccgcatg gggtgctggt atccgctact ttgataccgc accgttctat      900

ggcatgggtc tgagtgaacg ccgtctgggt cgcgcactgg ccagctatcc gcgtgatgcc      960

ttcgtgatta gcaccaaagt gggtcgttta ctgatcgccg acgacagtgt gccggaaacc     1020

cagcacggtt atgttggtgg tttaccgtac cgcgttgaat acgactatac tgccgatggc     1080

gcccgccgta gcattgaaag ctctttagaa cgtttaggtt tagatcgtat tgacattgtg     1140

tatattcacg acgtggccga ggatacccat ggtccgctgt ggcgtcagca ttatcgtacc     1200

gccgctggtg gtgcaatgaa agctttaagc cgtttacgcg atgaaggtgt gattggtggc     1260

tggggtttag gcgtgaatcg tgttgaaccg tgtctgatgg ctttagccga tgccgatccg     1320

gacgtctttt taatcgccgg ccgctatact ttactggata ccacagcttt agatgcttta     1380

attccggcat gcgaagcacg cggtgcacgt ttagttgttg gtggtccgta caatagtggt     1440

ttactggctg gtggcgatac ctttgaatat gcccgcgcag atgccgcaat gttagcccgt     1500

cgcgcacgtt tattaagcca ctgcgaacgc tttggtgttg atttaaaggc cgccgcttta     1560

cagttttgta aagccccggg cgttgttgca tgcgttattg ccggtgcccg caatgcagat     1620

gaggttcgtc agaactgcgc agcaatgaca gcaccggtgc cgcgcgaatt ttggcaagct     1680

ttaaaggaag agggcttagt tccgcaaggt gcaccggttc cggcataatc tagagtttaa     1740

ctttaagaag gagatatacc atggaaccga gtcagaatcc gagcgaaaag gtggcatgga     1800

ttgaacgcgc agatcccggc ctcgacgatc tgattgctcc agatgcgcaa gtggaagtgc     1860

tggcagaagg ttttgagtgg agcgaaggtc cggtatggat tcccgaaggc ggctacttgc     1920

tgtttagcga tgttccgaag aacaccattt accgctggaa agaaggtcag gggattgaca     1980

tcttcctgaa accgtcggga tataccggct ttcgtgaacg tggtggtgaa tcgggctcaa     2040

acggcttagc cctggatcgc caaggccgcc ttctgttgtg tcagcatggt gatcgtcgtg     2100

tagctcgttg ggagaaaggt tgctttatca cactggcaga ccagtatgag ggcaaaccgc     2160

tgaattcccc gaatgacttg gtagtcaagt cgaacggcga tatctacttc acggatccac     2220

catatggcat gactcctgag gcccaacgcg atcccaatgc gctcggcttt tgcggcgttt     2280

atcgcattag tgcggatggg aagctgacgc tgttagttcg tgacatgact cgccctaacg     2340

ggatcgcctt cagcccagac gagaaaacgc tctatgttgc ccagtcagat ccgcaacgcc     2400

cgttatggat ggcgttcccg gttcgcgaag atgggacctt aggggaaggc aaagtgttct     2460

tcgatgcgaa accgtggcag caaagtggct tgccgggact cccagatggc atgaaagtgg     2520

accagaaagg caatctgttt gcgactggtc cgggtggtgt caacatcttt cgccctgatg     2580

gtacctttct gggccggatt cgggtgaaag tccctaccgc taactgtgcg tttggtgatg     2640

acggatctac gctttacatt accgcggaca tgtatctgct tcgtgtgaaa acgaaaacca     2700

aaggactggg gttctaagtc gacctgcagg catgcaagct tctgttttgg cggatgagag     2760

aagaaattcg tcgcccgcca taaactgcca ggcatcaaat taagcagaag gccatcctga     2820

cggatggcct ttttgcgttt ctacaaactc ttcctgtcta gcaggtggca cttttcgggg     2880

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     2940

catgctagaa atattttatc tgattaataa gatgatcttc ttgagatcgt tttggtctgc     3000

gcgtaatctc ttgctctgaa aacgaaaaaa ccgccttgca gggcggtttt tcgaaggttc     3060

tctgagctac caactctttg aaccgaggta actggcttgg aggagcgcag tcaccaaaac     3120

ttgtcctttc agtttagcct taaccggcgc atgacttcaa gactaactcc tctaaatcaa     3180

ttaccagtgg ctgctgccag tggtgctttt gcatgtcttt ccgggttgga ctcaagacga     3240

tagttaccgg ataaggcgca gcggtcggac tgaacggggg gttcgtgcat acagtccagc     3300

ttggagcgaa ctgcctaccc ggaactgagt gtcaggcgtg gaatgagaca aacgcggcca     3360

taacagcgga atgacaccgg taaaccgaaa ggcaggaaca ggagagcgca cgagggagcc     3420

gccaggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacca ctgatttgag     3480

cgtcagattt cgtgatgctt gtcagggggg cggagcctat ggaaaaacgg ctttgccgcg     3540

gccctctcac ttccctgtta agtatcttcc tggcatcttc caggaaatct ccgccccgtt     3600

cgtaagccat ttccgctcgc cgcagtcgaa cgaccgagcg tagcgagtca gtgagcgagg     3660

aagcggaata tatcctgtat cacatattct gctgacgcac cggtgcagcc ttttttctcc     3720

tgccacatga agcacttcac tgacaccctc atcagtgcca acatagtaag ccagtataca     3780

ctccgctagc gctgatgtcc ggcggtgctt ttgccgttac gcaccacccc gtcagtagct     3840

gaacaggagg gacagctgat agaaacagaa gccactggag cacctcaaaa acaccatcat     3900

acactaaatc agtaagttgg cagcatcacc cgacgcactt tgcgccgaat aaatacctgt     3960

gacggaagat cacttcgcag aataaataaa tcctggtgtc cctgttgata ccgggaagcc     4020

ctgggccaac ttttggcgaa aatgagacgt tgatcggcac gtaagaggtt ccaactttca     4080

ccataatgaa ataagatcac taccgggcgt attttttgag ttatcgagat tttcaggagc     4140

taaggaagct aaaatggaga aaaaaatcac tggatatacc accgttgata tatcccaatg     4200

gcatcgtaaa gaacattttg aggcatttca gtcagttgct caatgtacct ataaccagac     4260

cgttcagctg gatattacgg cctttttaaa gaccgtaaag aaaaataagc acaagtttta     4320

tccggccttt attcacattc ttgcccgcct gatgaatgct catccggaat tccgtatggc     4380

aatgaaagac ggtgagctgg tgatatggga tagtgttcac ccttgttaca ccgttttcca     4440

tgagcaaact gaaacgtttt catcgctctg gagtgaatac cacgacgatt tccggcagtt     4500

tctacacata tattcgcaag atgtggcgtg ttacggtgaa aacctggcct atttccctaa     4560

agggtttatt gagaatatgt ttttcgtctc agccaatccc tgggtgagtt tcaccagttt     4620

tgatttaaac gtggccaata tggacaactt cttcgccccc gttttcacca tgggcaaata     4680

ttatacgcaa ggcgacaagg tgctgatgcc gctggcgatt caggttcatc atgccgtctg     4740

tgatggcttc catgtcggca gaatgcttaa tgaattacaa cagtactgcg atgagtggca     4800

gggcggggcg taattttttt aaggcagtta ttggtgccct taaacgcctg gtgctacgcc     4860

tgaataagtg ataataagcg gatgaatggc agaaattcga aagcaaattc gacccggtcg     4920

tcggttcagg gcagggtcgt taaatagccg cttatgtcta ttgctggttt accggtttat     4980

tgactaccgg aagcagtgtg accgtgtgct tctcaaatgc ctgaggccag tttgctcagg     5040

ctctccccgt ggaggtaata attgacgata tgatcattta ttctgcctcc cagagcctga     5100

taaaaacggt tagcgcttcg ttaatacaga tgtaggtgtt ccacagggta gccagcagca     5160

tcctgcgatg cagatccgga acataatggt gcagggcgct tgtttcggcg tgggtatggt     5220

ggcaggcccc gtggccgggg gactgttggg cgctgccggc acctgtccta cgagttgcat     5280

gataaagaag acagtcataa gtgcggcgac gatagtcatg ccccgcgccc accggaagga     5340

gctaccggac agcggtgcgg actgttgtaa ctcagaataa gaaatgaggc cgctcatggc     5400

gttgactctc agtcatagta tcgtggtatc accggttggt tccactctct gttgcgggca     5460

acttcagcag cacgtagggg acttccgcgt ttccagactt tacgaaacac ggaaaccgaa     5520

gaccattcat gttgttgctc aggtcgcaga cgttttgcag cagcagtcgc ttcacgttcg     5580

ctcgcgtatc ggtgattcat tctgctaacc agtaaggcaa ccccgccagc ctagccgggt     5640

cctcaacgac aggagcacga tcatgcgcac ccgtggccag gacccaacgc tgcccgagat     5700

gcgccgcgtg cggctgctgg agatggcgga cgcgatggat atgttctgcc aagggttggt     5760

ttgcgcattc acagttctcc gcaagaattg attggctcca attcttggag tggtgaatcc     5820

gttagcgagg tgccgccggc ttccattcag gtcgaggtgg cccggctcca tgcaccgcga     5880

cgcaacgcgg ggaggcagac aaggtatagg gcggcgccta caatccatgc caacccgttc     5940

catgtgctcg ccgaggcggc ataaatcgcc gtgacgatca gcggtccagt gatcgaagtt     6000

aggctggtaa gagccgcgag cgatccttga agctgtccct gatggtcgtc atctacctgc     6060

ctggacagca tggcctgcaa cgcgggcatc ccgatgccgc cggaagcgag aagaatcata     6120

atggggaagg ccatccagcc tcgcgtcgcg aacgccagca agacgtagcc cagcgcgtcg     6180

gccaattcgc gctaacttac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga     6240

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     6300

attgggcgcc agggtggttt ttcttttcac cagtgagacg ggcaacagct gattgccctt     6360

caccgcctgg ccctgagaga gttgcagcaa gcggtccacg ctggtttgcc ccagcaggcg     6420

aaaatcctgt ttgatggtgg ttgacggcgg gatataacat gagctgtctt cggtatcgtc     6480

gtatcccact accgagatat ccgcaccaac gcgcagcccg gactcggtaa tggcgcgcat     6540

tgcgcccagc gccatctgat cgttggcaac cagcatcgca gtgggaacga tgccctcatt     6600

cagcatttgc atggtttgtt gaaaaccgga catggcactc cagtcgcctt cccgttccgc     6660

tatcggctga atttgattgc gagtgagata tttatgccag ccagccagac gcagacgcgc     6720

cgagacagaa cttaatgggc ccgctaacag cgcgatttgc tggtgaccca atgcgaccag     6780

atgctccacg cccagtcgcg taccgtcttc atgggagaaa ataatactgt tgatgggtgt     6840

ctggtcagag acatcaagaa ataacgccgg aacattagtg caggcagctt ccacagcaat     6900

ggcatcctgg tcatccagcg gatagttaat gatcagccca ctgacgcgtt gcgcgagaag     6960

attgtgcacc gccgctttac aggcttcgac gccgcttcgt tctaccatcg acaccaccac     7020

gctggcaccc agttgatcgg cgcgagattt aatcgccgcg acaatttgcg acggcgcgtg     7080

cagggccaga ctggaggtgg caacgccaat cagcaacgac tgtttgcccg ccagttgttg     7140

tgccacgcgg ttgggaatgt aattcagctc cgccatcgcc gcttccactt tttcccgcgt     7200

tttcgcagaa acgtggctgg cctggttcac cacgcgggaa acggtctgat aagagacacc     7260

ggcatactct gcgacatcgt ataacgttac tggtttcaca ttcaccaccc tgaattgact     7320

ctcttccggg cgctatcatg ccataccgcg aaaggttttg caccattcga tggtgtcaac     7380

gtaaatgcat gccgcttcgc cttcgcgcgc gaattggccg ccatgccggc gataatggcc     7440

tgcttctcgc cgaaacgttt ggtggcggga ccagtgacga aggcttgagc gagggcgtgc     7500

aagattccga ataccgcaag cgacaggccg atcatcgtcg cgctccagcg aaagcggtcc     7560

tcgccgaaaa tgacccagag cgctgccggc acctgtccta cgagttgcat gataaagaag     7620

acagtcataa gtgcggcgac gatagtcatg ccccgcgccc accggaagga gctgactggg     7680

ttgaaggctc tcaagggcat cggcggagct tatcgactgc acggtgcacc aatgcttctg     7740

gcgtcaggca gccatcggaa gctgtggtat ggctgtgcag gtcgtaaatc actgcataat     7800

tcgtgtcgct caaggcgcac tcccgttctg gataatgttt tttgcgccga catcataacg     7860

gttctggcaa atattctgaa atgagctgtt gacaattaat catcggctcg tataatgtgt     7920

ggaattgtga gcggataaca atttcacaca ggaaacagaa ttcgagctcg gtacccgg       7978


<210>  169
<211>  8122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Plasmid

<400>  169
ggatccgttt aactttaaga aggagatata ccatggaact gtatctggat acttcagacg       60

ttgttgcggt gaaggcgctg tcacgtattt ttccgctggc gggtgtgacc actaacccaa      120

gcattatcgc cgcgggtaaa aaaccgctgg atgttgtgct tccgcaactt catgaagcga      180

tgggcggtca ggggcgtctg tttgcccagg taatggctac cactgccgaa gggatggtta      240

atgacgcgct taagctgcgt tctattattg cggatatcgt ggtgaaagtt ccggtgaccg      300

ccgaggggct ggcagctatt aagatgttaa aagcggaagg gattccgacg tatggaaccg      360

cggtatatgg cgcagcacaa gggctgctgt cggcgctggc aggtgcggaa tatgttggcc      420

cttacgttaa tcgtattgat gctcagggcg gtagcggcat tcagactgtg accgacttac      480

accagttatt gaaaatgcat gcgccgcagg cgaaagtgct ggcagcgagt ttcaaaaccc      540

cgcgtcaggc gctggactgc ttactggcag gatgtgaatc aattactctg ccactggatg      600

tggcacaaca gatgattagc tatccggcgg ttgatgccgc tgtggcgaag tttgagcagg      660

actggcaggg agcgtttggc agaacgtcga tttaaatgtt taactttaag aaggagatat      720

accatgaata cacgtcgcca attcctgtct gctgccgcgg ccggcaccac ggcgctggcc      780

gcatcgccat tgctggcaca gtcgtccgca cccggaagcg tgatgcccac gcgcggccgc      840

acggcggcct ctgccgtgca aactagcgcg ccggccaagg gcgcacgtta tcggccgacc      900

acgcggttgg gctttggcgg tgttgcaatc ggcaatgggt ttgcgccagc caccgatgcg      960

caaagcgagc agacgctggc ggcggtgtgg gcctcgggcg tgcgctattt cgatacctcg     1020

ccgtggtacg ggctgggcct gtccgaacgc cgcaccggcc atcatctgca taaccatgcc     1080

gccgatagct acgtgctctc gaccaaggtg gggcgcttgc tgaccgcgac cgacaagccg     1140

ccgaagacca tgtggcagca accgtccccg ttcgattacc gctacgacta cagcgccgcc     1200

ggcgtgcgcc gctcgatcga agacagcctg caacggctgg gcgtgtcgca gatcgacatc     1260

gtgtacatcc acgacctctc gccggagaac gaaaaagacc tcggcatgcc ctgggaacag     1320

cgctttgccg aggccgccaa gggcgcgatg ccggagctga ccaagatgcg caaggagggc     1380

ctgatcaagg cctggggctt tggcgtcaat cgcccggaac cggccttgcg tgcgattgaa     1440

gaagccgacc cggatatctt cttgctggcc tgccagtact cgttgctcga ccacgcgcag     1500

gccttgcatg acaccttccc gaagatcgcc agacacggcg cctcggtggt ggtgggcgcg     1560

ccgctgctgg ccggttatct ggccgggcgc gaccgttatc tgtacgaggg cacggtgccg     1620

gagtgggcgc cgggcaaacg ccagaaggcc ctggcaatct gcgacaaaca cggcgtggat     1680

ctgcgtacgg tgtcgctgca atttgctgcc gcaccggagg tggtgtcggc ggtgattccc     1740

ggcgcacgca cggccgaaca ggcgcaggcc aatgcggcct cgatgcgggt ggcgattcct     1800

gccgcgctct gggacgacct caagcgcgcg caggtgatcg aagcggatgc gccggtgccg     1860

gcggctggat gatctagagt ttaactttaa gaaggagata taccatggaa ccgagtcaga     1920

atccgagcga aaaggtggca tggattgaac gcgcagatcc cggcctcgac gatctgattg     1980

ctccagatgc gcaagtggaa gtgctggcag aaggttttga gtggagcgaa ggtccggtat     2040

ggattcccga aggcggctac ttgctgttta gcgatgttcc gaagaacacc atttaccgct     2100

ggaaagaagg tcaggggatt gacatcttcc tgaaaccgtc gggatatacc ggctttcgtg     2160

aacgtggtgg tgaatcgggc tcaaacggct tagccctgga tcgccaaggc cgccttctgt     2220

tgtgtcagca tggtgatcgt cgtgtagctc gttgggagaa aggttgcttt atcacactgg     2280

cagaccagta tgagggcaaa ccgctgaatt ccccgaatga cttggtagtc aagtcgaacg     2340

gcgatatcta cttcacggat ccaccatatg gcatgactcc tgaggcccaa cgcgatccca     2400

atgcgctcgg cttttgcggc gtttatcgca ttagtgcgga tgggaagctg acgctgttag     2460

ttcgtgacat gactcgccct aacgggatcg ccttcagccc agacgagaaa acgctctatg     2520

ttgcccagtc agatccgcaa cgcccgttat ggatggcgtt cccggttcgc gaagatggga     2580

ccttagggga aggcaaagtg ttcttcgatg cgaaaccgtg gcagcaaagt ggcttgccgg     2640

gactcccaga tggcatgaaa gtggaccaga aaggcaatct gtttgcgact ggtccgggtg     2700

gtgtcaacat ctttcgccct gatggtacct ttctgggccg gattcgggtg aaagtcccta     2760

ccgctaactg tgcgtttggt gatgacggat ctacgcttta cattaccgcg gacatgtatc     2820

tgcttcgtgt gaaaacgaaa accaaaggac tggggttcta agtcgacctg caggcatgca     2880

agcttctgtt ttggcggatg agagaagaaa ttcgtcgccc gccataaact gccaggcatc     2940

aaattaagca gaaggccatc ctgacggatg gcctttttgc gtttctacaa actcttcctg     3000

tctagcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta     3060

aatacattca aatatgtatc cgctcatgct agaaatattt tatctgatta ataagatgat     3120

cttcttgaga tcgttttggt ctgcgcgtaa tctcttgctc tgaaaacgaa aaaaccgcct     3180

tgcagggcgg tttttcgaag gttctctgag ctaccaactc tttgaaccga ggtaactggc     3240

ttggaggagc gcagtcacca aaacttgtcc tttcagttta gccttaaccg gcgcatgact     3300

tcaagactaa ctcctctaaa tcaattacca gtggctgctg ccagtggtgc ttttgcatgt     3360

ctttccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc ggactgaacg     3420

gggggttcgt gcatacagtc cagcttggag cgaactgcct acccggaact gagtgtcagg     3480

cgtggaatga gacaaacgcg gccataacag cggaatgaca ccggtaaacc gaaaggcagg     3540

aacaggagag cgcacgaggg agccgccagg ggaaacgcct ggtatcttta tagtcctgtc     3600

gggtttcgcc accactgatt tgagcgtcag atttcgtgat gcttgtcagg ggggcggagc     3660

ctatggaaaa acggctttgc cgcggccctc tcacttccct gttaagtatc ttcctggcat     3720

cttccaggaa atctccgccc cgttcgtaag ccatttccgc tcgccgcagt cgaacgaccg     3780

agcgtagcga gtcagtgagc gaggaagcgg aatatatcct gtatcacata ttctgctgac     3840

gcaccggtgc agcctttttt ctcctgccac atgaagcact tcactgacac cctcatcagt     3900

gccaacatag taagccagta tacactccgc tagcgctgat gtccggcggt gcttttgccg     3960

ttacgcacca ccccgtcagt agctgaacag gagggacagc tgatagaaac agaagccact     4020

ggagcacctc aaaaacacca tcatacacta aatcagtaag ttggcagcat cacccgacgc     4080

actttgcgcc gaataaatac ctgtgacgga agatcacttc gcagaataaa taaatcctgg     4140

tgtccctgtt gataccggga agccctgggc caacttttgg cgaaaatgag acgttgatcg     4200

gcacgtaaga ggttccaact ttcaccataa tgaaataaga tcactaccgg gcgtattttt     4260

tgagttatcg agattttcag gagctaagga agctaaaatg gagaaaaaaa tcactggata     4320

taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat ttcagtcagt     4380

tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt taaagaccgt     4440

aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc gcctgatgaa     4500

tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat gggatagtgt     4560

tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc tctggagtga     4620

ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg cgtgttacgg     4680

tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg tctcagccaa     4740

tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca acttcttcgc     4800

ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga tgccgctggc     4860

gattcaggtt catcatgccg tctgtgatgg cttccatgtc ggcagaatgc ttaatgaatt     4920

acaacagtac tgcgatgagt ggcagggcgg ggcgtaattt ttttaaggca gttattggtg     4980

cccttaaacg cctggtgcta cgcctgaata agtgataata agcggatgaa tggcagaaat     5040

tcgaaagcaa attcgacccg gtcgtcggtt cagggcaggg tcgttaaata gccgcttatg     5100

tctattgctg gtttaccggt ttattgacta ccggaagcag tgtgaccgtg tgcttctcaa     5160

atgcctgagg ccagtttgct caggctctcc ccgtggaggt aataattgac gatatgatca     5220

tttattctgc ctcccagagc ctgataaaaa cggttagcgc ttcgttaata cagatgtagg     5280

tgttccacag ggtagccagc agcatcctgc gatgcagatc cggaacataa tggtgcaggg     5340

cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc gggggactgt tgggcgctgc     5400

cggcacctgt cctacgagtt gcatgataaa gaagacagtc ataagtgcgg cgacgatagt     5460

catgccccgc gcccaccgga aggagctacc ggacagcggt gcggactgtt gtaactcaga     5520

ataagaaatg aggccgctca tggcgttgac tctcagtcat agtatcgtgg tatcaccggt     5580

tggttccact ctctgttgcg ggcaacttca gcagcacgta ggggacttcc gcgtttccag     5640

actttacgaa acacggaaac cgaagaccat tcatgttgtt gctcaggtcg cagacgtttt     5700

gcagcagcag tcgcttcacg ttcgctcgcg tatcggtgat tcattctgct aaccagtaag     5760

gcaaccccgc cagcctagcc gggtcctcaa cgacaggagc acgatcatgc gcacccgtgg     5820

ccaggaccca acgctgcccg agatgcgccg cgtgcggctg ctggagatgg cggacgcgat     5880

ggatatgttc tgccaagggt tggtttgcgc attcacagtt ctccgcaaga attgattggc     5940

tccaattctt ggagtggtga atccgttagc gaggtgccgc cggcttccat tcaggtcgag     6000

gtggcccggc tccatgcacc gcgacgcaac gcggggaggc agacaaggta tagggcggcg     6060

cctacaatcc atgccaaccc gttccatgtg ctcgccgagg cggcataaat cgccgtgacg     6120

atcagcggtc cagtgatcga agttaggctg gtaagagccg cgagcgatcc ttgaagctgt     6180

ccctgatggt cgtcatctac ctgcctggac agcatggcct gcaacgcggg catcccgatg     6240

ccgccggaag cgagaagaat cataatgggg aaggccatcc agcctcgcgt cgcgaacgcc     6300

agcaagacgt agcccagcgc gtcggccaat tcgcgctaac ttacattaat tgcgttgcgc     6360

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     6420

cgcgcgggga gaggcggttt gcgtattggg cgccagggtg gtttttcttt tcaccagtga     6480

gacgggcaac agctgattgc ccttcaccgc ctggccctga gagagttgca gcaagcggtc     6540

cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg gtggttgacg gcgggatata     6600

acatgagctg tcttcggtat cgtcgtatcc cactaccgag atatccgcac caacgcgcag     6660

cccggactcg gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg caaccagcat     6720

cgcagtggga acgatgccct cattcagcat ttgcatggtt tgttgaaaac cggacatggc     6780

actccagtcg ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga gatatttatg     6840

ccagccagcc agacgcagac gcgccgagac agaacttaat gggcccgcta acagcgcgat     6900

ttgctggtga cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt cttcatggga     6960

gaaaataata ctgttgatgg gtgtctggtc agagacatca agaaataacg ccggaacatt     7020

agtgcaggca gcttccacag caatggcatc ctggtcatcc agcggatagt taatgatcag     7080

cccactgacg cgttgcgcga gaagattgtg caccgccgct ttacaggctt cgacgccgct     7140

tcgttctacc atcgacacca ccacgctggc acccagttga tcggcgcgag atttaatcgc     7200

cgcgacaatt tgcgacggcg cgtgcagggc cagactggag gtggcaacgc caatcagcaa     7260

cgactgtttg cccgccagtt gttgtgccac gcggttggga atgtaattca gctccgccat     7320

cgccgcttcc actttttccc gcgttttcgc agaaacgtgg ctggcctggt tcaccacgcg     7380

ggaaacggtc tgataagaga caccggcata ctctgcgaca tcgtataacg ttactggttt     7440

cacattcacc accctgaatt gactctcttc cgggcgctat catgccatac cgcgaaaggt     7500

tttgcaccat tcgatggtgt caacgtaaat gcatgccgct tcgccttcgc gcgcgaattg     7560

gccgccatgc cggcgataat ggcctgcttc tcgccgaaac gtttggtggc gggaccagtg     7620

acgaaggctt gagcgagggc gtgcaagatt ccgaataccg caagcgacag gccgatcatc     7680

gtcgcgctcc agcgaaagcg gtcctcgccg aaaatgaccc agagcgctgc cggcacctgt     7740

cctacgagtt gcatgataaa gaagacagtc ataagtgcgg cgacgatagt catgccccgc     7800

gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggcgg agcttatcga     7860

ctgcacggtg caccaatgct tctggcgtca ggcagccatc ggaagctgtg gtatggctgt     7920

gcaggtcgta aatcactgca taattcgtgt cgctcaaggc gcactcccgt tctggataat     7980

gttttttgcg ccgacatcat aacggttctg gcaaatattc tgaaatgagc tgttgacaat     8040

taatcatcgg ctcgtataat gtgtggaatt gtgagcggat aacaatttca cacaggaaac     8100

agaattcgag ctcggtaccc gg                                              8122


<210>  170
<211>  9033
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Plasmid

<400>  170
ggtaccgttt aactttaaga aggagatata ccatggctga tacaatgctc gccgccgtcg       60

tccgtgaatt cggcaagccg ctctccatcg agcggctacc catcccggac atcaagcccc      120

accagatcct cgtgaaggtc gatacctgtg gcgtctgcca cactgacctg cacgccgcgc      180

gcggggactg gccgtccaag cccaacccgc cgttcattcc cgggcatgaa ggcgtcggac      240

acatcgtcgc cgtcggcagt caggtcggcg atttcgtcaa gaccggcgat gtcgtgggcg      300

tgccctggct ctactccgcc tgcggtcact gcgaacactg tctgggcggc tgggaaacac      360

tctgcgaaaa gcaggacgac accggctaca ccgtcaatgg ctgcttcgcc gaatatgtcg      420

tggcagaccc gaactacgtc gcacacctgc cctcgaccat cgacccgctt caggcctcgc      480

cggtcctgtg cgcggggctg acggtctata agggcctgaa aatgacggag gcccgccccg      540

gccagtgggt cgcagtctcg ggcgtcggcg gtctcggcca gatggccgtg cagtacgccg      600

tcgccatggg catgaatgtc gtcgcggtgg acatcgatga cgaaaaactc gccacagcca      660

aaaagctcgg cgcatccctg accgtcaacg ccaaggacac ggacccggcc aggttcatcc      720

agcagcagat cggcggcgca catggcgctc tcgtcaccgc tgtcggacgg acggcgtttt      780

cgcaggccat gggctatgcc cgccgcggcg gcaccatcgt cctgaacgga ctgccgcccg      840

gcgatttccc ggtctcgatc ttcgacatgg tcatgaacgg caccaccatc cgtggctcca      900

tcgtcggaac acggctggac atgatcgagg ccatggattt cttcgcccgc ggcaaggtca      960

aatccgtcgt cacccccgga aaacttgaaa acatcaatac gatcttcgac gatctgcaga     1020

atggtcgcct cgaaggccgg acagtgctcg acttccggtc ctaaggatcc gtttaacttt     1080

aagaaggaga tataccatgg aactgtatct ggatacttca gacgttgttg cggtgaaggc     1140

gctgtcacgt atttttccgc tggcgggtgt gaccactaac ccaagcatta tcgccgcggg     1200

taaaaaaccg ctggatgttg tgcttccgca acttcatgaa gcgatgggcg gtcaggggcg     1260

tctgtttgcc caggtaatgg ctaccactgc cgaagggatg gttaatgacg cgcttaagct     1320

gcgttctatt attgcggata tcgtggtgaa agttccggtg accgccgagg ggctggcagc     1380

tattaagatg ttaaaagcgg aagggattcc gacgtatgga accgcggtat atggcgcagc     1440

acaagggctg ctgtcggcgc tggcaggtgc ggaatatgtt ggcccttacg ttaatcgtat     1500

tgatgctcag ggcggtagcg gcattcagac tgtgaccgac ttacaccagt tattgaaaat     1560

gcatgcgccg caggcgaaag tgctggcagc gagtttcaaa accccgcgtc aggcgctgga     1620

ctgcttactg gcaggatgtg aatcaattac tctgccactg gatgtggcac aacagatgat     1680

tagctatccg gcggttgatg ccgctgtggc gaagtttgag caggactggc agggagcgtt     1740

tggcagaacg tcgatttaaa tgtttaactt taagaaggag atataccatg tctaccgata     1800

gtttacaaca gtttcgtcgc cgtgtggcaa ttccgggtcc ggctggtttt ggtgcagcac     1860

cgctgggcaa tctgtttagc cgtgttaccg atgaggccgc acaagaaact ttaagtgccg     1920

catggggtgc tggtatccgc tactttgata ccgcaccgtt ctatggcatg ggtctgagtg     1980

aacgccgtct gggtcgcgca ctggccagct atccgcgtga tgccttcgtg attagcacca     2040

aagtgggtcg tttactgatc gccgacgaca gtgtgccgga aacccagcac ggttatgttg     2100

gtggtttacc gtaccgcgtt gaatacgact atactgccga tggcgcccgc cgtagcattg     2160

aaagctcttt agaacgttta ggtttagatc gtattgacat tgtgtatatt cacgacgtgg     2220

ccgaggatac ccatggtccg ctgtggcgtc agcattatcg taccgccgct ggtggtgcaa     2280

tgaaagcttt aagccgttta cgcgatgaag gtgtgattgg tggctggggt ttaggcgtga     2340

atcgtgttga accgtgtctg atggctttag ccgatgccga tccggacgtc tttttaatcg     2400

ccggccgcta tactttactg gataccacag ctttagatgc tttaattccg gcatgcgaag     2460

cacgcggtgc acgtttagtt gttggtggtc cgtacaatag tggtttactg gctggtggcg     2520

atacctttga atatgcccgc gcagatgccg caatgttagc ccgtcgcgca cgtttattaa     2580

gccactgcga acgctttggt gttgatttaa aggccgccgc tttacagttt tgtaaagccc     2640

cgggcgttgt tgcatgcgtt attgccggtg cccgcaatgc agatgaggtt cgtcagaact     2700

gcgcagcaat gacagcaccg gtgccgcgcg aattttggca agctttaaag gaagagggct     2760

tagttccgca aggtgcaccg gttccggcat aatctagagt ttaactttaa gaaggagata     2820

taccatggaa ccgagtcaga atccgagcga aaaggtggca tggattgaac gcgcagatcc     2880

cggcctcgac gatctgattg ctccagatgc gcaagtggaa gtgctggcag aaggttttga     2940

gtggagcgaa ggtccggtat ggattcccga aggcggctac ttgctgttta gcgatgttcc     3000

gaagaacacc atttaccgct ggaaagaagg tcaggggatt gacatcttcc tgaaaccgtc     3060

gggatatacc ggctttcgtg aacgtggtgg tgaatcgggc tcaaacggct tagccctgga     3120

tcgccaaggc cgccttctgt tgtgtcagca tggtgatcgt cgtgtagctc gttgggagaa     3180

aggttgcttt atcacactgg cagaccagta tgagggcaaa ccgctgaatt ccccgaatga     3240

cttggtagtc aagtcgaacg gcgatatcta cttcacggat ccaccatatg gcatgactcc     3300

tgaggcccaa cgcgatccca atgcgctcgg cttttgcggc gtttatcgca ttagtgcgga     3360

tgggaagctg acgctgttag ttcgtgacat gactcgccct aacgggatcg ccttcagccc     3420

agacgagaaa acgctctatg ttgcccagtc agatccgcaa cgcccgttat ggatggcgtt     3480

cccggttcgc gaagatggga ccttagggga aggcaaagtg ttcttcgatg cgaaaccgtg     3540

gcagcaaagt ggcttgccgg gactcccaga tggcatgaaa gtggaccaga aaggcaatct     3600

gtttgcgact ggtccgggtg gtgtcaacat ctttcgccct gatggtacct ttctgggccg     3660

gattcgggtg aaagtcccta ccgctaactg tgcgtttggt gatgacggat ctacgcttta     3720

cattaccgcg gacatgtatc tgcttcgtgt gaaaacgaaa accaaaggac tggggttcta     3780

agtcgacctg caggcatgca agcttctgtt ttggcggatg agagaagaaa ttcgtcgccc     3840

gccataaact gccaggcatc aaattaagca gaaggccatc ctgacggatg gcctttttgc     3900

gtttctacaa actcttcctg tctagcaggt ggcacttttc ggggaaatgt gcgcggaacc     3960

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgct agaaatattt     4020

tatctgatta ataagatgat cttcttgaga tcgttttggt ctgcgcgtaa tctcttgctc     4080

tgaaaacgaa aaaaccgcct tgcagggcgg tttttcgaag gttctctgag ctaccaactc     4140

tttgaaccga ggtaactggc ttggaggagc gcagtcacca aaacttgtcc tttcagttta     4200

gccttaaccg gcgcatgact tcaagactaa ctcctctaaa tcaattacca gtggctgctg     4260

ccagtggtgc ttttgcatgt ctttccgggt tggactcaag acgatagtta ccggataagg     4320

cgcagcggtc ggactgaacg gggggttcgt gcatacagtc cagcttggag cgaactgcct     4380

acccggaact gagtgtcagg cgtggaatga gacaaacgcg gccataacag cggaatgaca     4440

ccggtaaacc gaaaggcagg aacaggagag cgcacgaggg agccgccagg ggaaacgcct     4500

ggtatcttta tagtcctgtc gggtttcgcc accactgatt tgagcgtcag atttcgtgat     4560

gcttgtcagg ggggcggagc ctatggaaaa acggctttgc cgcggccctc tcacttccct     4620

gttaagtatc ttcctggcat cttccaggaa atctccgccc cgttcgtaag ccatttccgc     4680

tcgccgcagt cgaacgaccg agcgtagcga gtcagtgagc gaggaagcgg aatatatcct     4740

gtatcacata ttctgctgac gcaccggtgc agcctttttt ctcctgccac atgaagcact     4800

tcactgacac cctcatcagt gccaacatag taagccagta tacactccgc tagcgctgat     4860

gtccggcggt gcttttgccg ttacgcacca ccccgtcagt agctgaacag gagggacagc     4920

tgatagaaac agaagccact ggagcacctc aaaaacacca tcatacacta aatcagtaag     4980

ttggcagcat cacccgacgc actttgcgcc gaataaatac ctgtgacgga agatcacttc     5040

gcagaataaa taaatcctgg tgtccctgtt gataccggga agccctgggc caacttttgg     5100

cgaaaatgag acgttgatcg gcacgtaaga ggttccaact ttcaccataa tgaaataaga     5160

tcactaccgg gcgtattttt tgagttatcg agattttcag gagctaagga agctaaaatg     5220

gagaaaaaaa tcactggata taccaccgtt gatatatccc aatggcatcg taaagaacat     5280

tttgaggcat ttcagtcagt tgctcaatgt acctataacc agaccgttca gctggatatt     5340

acggcctttt taaagaccgt aaagaaaaat aagcacaagt tttatccggc ctttattcac     5400

attcttgccc gcctgatgaa tgctcatccg gaattccgta tggcaatgaa agacggtgag     5460

ctggtgatat gggatagtgt tcacccttgt tacaccgttt tccatgagca aactgaaacg     5520

ttttcatcgc tctggagtga ataccacgac gatttccggc agtttctaca catatattcg     5580

caagatgtgg cgtgttacgg tgaaaacctg gcctatttcc ctaaagggtt tattgagaat     5640

atgtttttcg tctcagccaa tccctgggtg agtttcacca gttttgattt aaacgtggcc     5700

aatatggaca acttcttcgc ccccgttttc accatgggca aatattatac gcaaggcgac     5760

aaggtgctga tgccgctggc gattcaggtt catcatgccg tctgtgatgg cttccatgtc     5820

ggcagaatgc ttaatgaatt acaacagtac tgcgatgagt ggcagggcgg ggcgtaattt     5880

ttttaaggca gttattggtg cccttaaacg cctggtgcta cgcctgaata agtgataata     5940

agcggatgaa tggcagaaat tcgaaagcaa attcgacccg gtcgtcggtt cagggcaggg     6000

tcgttaaata gccgcttatg tctattgctg gtttaccggt ttattgacta ccggaagcag     6060

tgtgaccgtg tgcttctcaa atgcctgagg ccagtttgct caggctctcc ccgtggaggt     6120

aataattgac gatatgatca tttattctgc ctcccagagc ctgataaaaa cggttagcgc     6180

ttcgttaata cagatgtagg tgttccacag ggtagccagc agcatcctgc gatgcagatc     6240

cggaacataa tggtgcaggg cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc     6300

gggggactgt tgggcgctgc cggcacctgt cctacgagtt gcatgataaa gaagacagtc     6360

ataagtgcgg cgacgatagt catgccccgc gcccaccgga aggagctacc ggacagcggt     6420

gcggactgtt gtaactcaga ataagaaatg aggccgctca tggcgttgac tctcagtcat     6480

agtatcgtgg tatcaccggt tggttccact ctctgttgcg ggcaacttca gcagcacgta     6540

ggggacttcc gcgtttccag actttacgaa acacggaaac cgaagaccat tcatgttgtt     6600

gctcaggtcg cagacgtttt gcagcagcag tcgcttcacg ttcgctcgcg tatcggtgat     6660

tcattctgct aaccagtaag gcaaccccgc cagcctagcc gggtcctcaa cgacaggagc     6720

acgatcatgc gcacccgtgg ccaggaccca acgctgcccg agatgcgccg cgtgcggctg     6780

ctggagatgg cggacgcgat ggatatgttc tgccaagggt tggtttgcgc attcacagtt     6840

ctccgcaaga attgattggc tccaattctt ggagtggtga atccgttagc gaggtgccgc     6900

cggcttccat tcaggtcgag gtggcccggc tccatgcacc gcgacgcaac gcggggaggc     6960

agacaaggta tagggcggcg cctacaatcc atgccaaccc gttccatgtg ctcgccgagg     7020

cggcataaat cgccgtgacg atcagcggtc cagtgatcga agttaggctg gtaagagccg     7080

cgagcgatcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac agcatggcct     7140

gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg aaggccatcc     7200

agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccaat tcgcgctaac     7260

ttacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc     7320

tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgccagggtg     7380

gtttttcttt tcaccagtga gacgggcaac agctgattgc ccttcaccgc ctggccctga     7440

gagagttgca gcaagcggtc cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg     7500

gtggttgacg gcgggatata acatgagctg tcttcggtat cgtcgtatcc cactaccgag     7560

atatccgcac caacgcgcag cccggactcg gtaatggcgc gcattgcgcc cagcgccatc     7620

tgatcgttgg caaccagcat cgcagtggga acgatgccct cattcagcat ttgcatggtt     7680

tgttgaaaac cggacatggc actccagtcg ccttcccgtt ccgctatcgg ctgaatttga     7740

ttgcgagtga gatatttatg ccagccagcc agacgcagac gcgccgagac agaacttaat     7800

gggcccgcta acagcgcgat ttgctggtga cccaatgcga ccagatgctc cacgcccagt     7860

cgcgtaccgt cttcatggga gaaaataata ctgttgatgg gtgtctggtc agagacatca     7920

agaaataacg ccggaacatt agtgcaggca gcttccacag caatggcatc ctggtcatcc     7980

agcggatagt taatgatcag cccactgacg cgttgcgcga gaagattgtg caccgccgct     8040

ttacaggctt cgacgccgct tcgttctacc atcgacacca ccacgctggc acccagttga     8100

tcggcgcgag atttaatcgc cgcgacaatt tgcgacggcg cgtgcagggc cagactggag     8160

gtggcaacgc caatcagcaa cgactgtttg cccgccagtt gttgtgccac gcggttggga     8220

atgtaattca gctccgccat cgccgcttcc actttttccc gcgttttcgc agaaacgtgg     8280

ctggcctggt tcaccacgcg ggaaacggtc tgataagaga caccggcata ctctgcgaca     8340

tcgtataacg ttactggttt cacattcacc accctgaatt gactctcttc cgggcgctat     8400

catgccatac cgcgaaaggt tttgcaccat tcgatggtgt caacgtaaat gcatgccgct     8460

tcgccttcgc gcgcgaattg gccgccatgc cggcgataat ggcctgcttc tcgccgaaac     8520

gtttggtggc gggaccagtg acgaaggctt gagcgagggc gtgcaagatt ccgaataccg     8580

caagcgacag gccgatcatc gtcgcgctcc agcgaaagcg gtcctcgccg aaaatgaccc     8640

agagcgctgc cggcacctgt cctacgagtt gcatgataaa gaagacagtc ataagtgcgg     8700

cgacgatagt catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg     8760

gcatcggcgg agcttatcga ctgcacggtg caccaatgct tctggcgtca ggcagccatc     8820

ggaagctgtg gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc     8880

gcactcccgt tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc     8940

tgaaatgagc tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat     9000

aacaatttca cacaggaaac agaattcgag ctc                                  9033


<210>  171
<211>  8592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Plasmid

<400>  171
gagctcgttt aactttaaga aggagatata ccatgaaagt cgcagtcctc ggcgccgctg       60

gcggtgtcgg ccaggcgctt gcactactgt taaaaaccca actgccttca ggttcagaac      120

tctctctgta tgatatcgct ccagtgactc ccggtgtggc tgtcgatctg agccatatcc      180

ctactgctgt gaaaatcaaa ggtttttctg gtgaagatgc gactccggcg ctggaaggcg      240

cagatgtcgt tcttatctct gcaggcgtag cggctaaacc gggccagtct cgttccgacc      300

tgtttaacgt taacgccggc atcgtgaaaa acctggtaca gcaagttgcg aaaacctgcc      360

cgaaagcgtg cattggtatt atcactaacc cggttaacac cacagttgca attgctgctg      420

aagtgctgaa aaaagccggt gtttatgaca aaaacaaact gttcggcgtt accacgctgg      480

atatcattcg ttccaacacc tttgttgcgg aactgaaagg caaacagcca ggcgaagttg      540

aagtgccggt tattggcggc cactctgatg ttaccattct gccgctgctg tcacaggttc      600

ctggcgttag ttttaccgag caggaagtgg ctgatctgac caaacgcatc cagaacgcgg      660

gtactgaagt ggttgaagcg aaggccggtg gcgggtctgc aaccctgtct atgggccagg      720

cagctgcacg ttttggtctg tctctggttc gtgcactgca gggcgaacaa ggcgttgtcg      780

aatgtgccta cgttgaaggc gacggtcagt acgcccgttt cttctctcaa ccgctgctgc      840

tgggtaaaaa cggcgtggaa gagcgtaaat ctatcggtac cctgagcgca tttgaacaga      900

acgcgctgga aggtatgctg gatacgctga agaaagatat cgccctgggc gaagagttcg      960

ttaataagta aggatccgtt taactttaag aaggagatat accatgaaag ccaactctcc     1020

cgtcatccgc ctgaacccgg tcgatgatgt cgtcatcgcc cgccagcagc tcatctccgg     1080

caccgtgctg caggacgaag gcggcctcaa agtccagggc ctcattcccg ccggccacaa     1140

gatggcgacc cgcgccatct ctgcgggcga gccggtcaag cgctatggcc agatcatcgg     1200

cacggccagc caggacatcg cgcccggaca gcacgtgcac acgcacaacc tggccatggc     1260

cgagttctcg cgtgaacacc atttcggcgc tgacgtgaag ccggtcgatt tcgtcgccga     1320

gcccgcaacc ttcatgggca tcgtgcgtcc cgatggccgc gtggccacgc gcaactacat     1380

cggcgtactg acctcggtga actgctcggc caccgcggca cgcgccatcg ccgattactt     1440

ccgccgcgac atccatcccg aagtgctggc cgactatccc aacatcgatg gcgtggtggc     1500

cctgacccat ggccagggtt gcgccacgga ttcgcagggc gagccgctgc agatcctgcg     1560

ccgcacgctg gcgggttacg ccacgcatcc caacttcgct gcggtgctgg tggtgggcct     1620

gggctgcgag accaaccaga tctcgggcct gatggaaagc cacaacctga aggaaggcga     1680

atacttccac accttcacca tccagggcac cggcggcacc gccaagaccg tggcgctggg     1740

gatcgagaag atcaagaaga tgctgcccaa ggccaatgac atcaagcgcg agccggtgtc     1800

ggccaagcat ctgacgctgg gcctgcagtg cggtggttcg gatggctatt cgggcatcac     1860

ggccaatccg gcgctgggtg cggcagtgga cttgctggtg cggcatggcg gcacggccat     1920

cctttccgaa acgccggaaa tctatggggc cgaacacctg ctcacccgcc gcgcggtctc     1980

gccggaagtc ggtgagaagc tgctggcccg catcgcctgg tgggaggagt attgcgccaa     2040

gaacgatgcc gagatgaaca acaatccctc agcgggcaac aaggccggtg gcttgaccac     2100

catcctcgag aagtcgctgg gcgcggttgc caagggtggc actaccaatc tggtggatgt     2160

ctacaagtat gcggagacgg tcaccgcacg cggcttcgtc ttcatggata cgccgggcta     2220

cgacccgatc tccgccaccg gccaggtcgc cggaggggcc aacatgatct gcttcaccac     2280

gggccggggt tctgcctatg gctgcgcacc ggcaccgtcg ctcaagctgg ccaccaatac     2340

tgcgctgtgg caacgtcagg aagaagacat ggatatcaac tgcggcgaga ttgccgacag     2400

caatgtcacc ccgcaggagg tcggcgaacg cttcttccag atgatcctcg atacggcatc     2460

gggcaagaag accaagagcg agctgcatgg ctacgggcaa gacgaattcg tgccctggca     2520

catcggcgtc tacacctgat ctagagtcga cctgcaggca tgcaagcttc tgttttggcg     2580

gatgagagaa gaaattcgtc gcccgccata aactgccagg catcaaatta agcagaaggc     2640

catcctgacg gatggccttt ttgcgtttct acaaactctt cctgtctagc aggtggcact     2700

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     2760

tatccgctca tgagcttcac gctgccgcaa gcactcaggg cgcaagggct gctaaaggaa     2820

gcggaacacg tagaaagcca gtccgcagaa acggtgctga ccccggatga atgtcagcta     2880

ctgggctatc tggacaaggg aaaacgcaag cgcaaagaga aagcaggtag cttgcagtgg     2940

gcttacatgg cgatagctag actgggcggt tttatggaca gcaagcgaac cggaattgcc     3000

agctggggcg ccctctggta aggttgggaa gccctgcaaa gtaaactgga tggctttctt     3060

gccgccaagg atctgatggc gcaggggatc aagatctgat caagagacag gatgaggatc     3120

gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag     3180

gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg     3240

gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa     3300

tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc     3360

agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc     3420

ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga     3480

tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa     3540

acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct     3600

ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgcgcat     3660

gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt     3720

ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta     3780

tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga     3840

ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg     3900

ccttcttgac gagttcttct gagcgggact ctggggttcg aaatgaccga ccaagcgacg     3960

cccaacctgc catcacgaga tttcgattcc accgccgcct tctatgaaag gttgggcttc     4020

ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct catgctggag     4080

ttcttcgccc accccgatat tgattacgtg tttgaatcat tgcatcgcct gtaaattttt     4140

aacttgtcct atttttgtca ttaccacgta tatacacatg tataacaatt cagatatcgt     4200

taccaggata tgccgcatca gcggcatgga aggcggcact ctgttgtttc atatgataca     4260

ggagtaaaac cgccgaagcc cggcgtaagc cggtactgat tgatagattt caccttaccc     4320

atccccagcc ctgccagacc atacccgctt tcagccatga gagagcttct gtgcgcggtc     4380

ggagtggtcc cgacgagggt ttacccgaag tcggggcgta tctccgcgtt agcgggccgt     4440

cagggccgct tacgagcgtg tactgagaac ttccagcgag aagactgaca gcgatgatga     4500

agtagttaca acattcataa ttaaaagcga ctctgttccg gcccttcggg ccggggcggg     4560

gccgcttttc agttatgagg gaggggcttt gtggtttcag ttctgcgctg gaccggggtt     4620

tttctggtgg ttgtgtctga gtgttgtaac taaagcggct ccggtagggg cccgccgctt     4680

gcggtgggag gtgcatatct gtctgtccac aggacaggca gtgaataggt tttcttttta     4740

aatgaatgta attaagtagt ttaaaggaga tataaacagg tgtttaaaag atacattgca     4800

ccctgtaacg ctggcggatg gcgctttatg acatgaacgg ttgtaacctt atggggaagt     4860

cccttgcagt ttaatgtgga taagcaaaat tccccgtctg tgaggcgtgt tttgtatcga     4920

aaacaggggg ggccggatgc accagaagct ggatgatgag gttgtttttt gtatgtggtg     4980

ctgatttttt gtgcgctgtc gggcttcaga cgtgcggaag cctccggcgc aggccggatt     5040

attcagagga ggtcactttc agggggaagc tgtggccagc cggctgtaat tacggttacg     5100

tgacagaatc atgcgctcct tcacacgacg ctcaacttcg cgttttaccg cctcacgatt     5160

ggcagtgaag cgcccttccg cgatttcgcg cgtcagctgc cgtttcacca gggtgacaat     5220

atcctgacgt tccctgtccg catcacgacg cgcacgggca cgctttattc cccgggactt     5280

aagctctgtc tgataactgc gaaaacgctc acgaacaaaa cgccaggctt tcgctatcag     5340

ttcatccatg cccagggtat ccagcccctg ctttttgcgt tgtttgtttt cccataccac     5400

acggctgcgg cgcgcggcgg ccactgcctc ctctgataca tcgagggcag caaacagtgc     5460

agatgtgaac gtgatatcgg tcggaatgta gcacccgata agcgggtcat attccgtctg     5520

gtaggtaatc agtcccagct ctgacaggaa cgtcagggcc cgggtggcac gggtgatgga     5580

gagttttccg gcagcagact ccgtcgccag tccgcactca atggccagcg tggtgatgga     5640

gcactggacg cggttggcca gcgggtcata gtggaaacac agcccctgca ggagcgcatc     5700

aatagcccgt cgacgcagca ctggtggcat gcgtcgacgc agaccacgcg aacgggcatg     5760

cgccacatga atggcgaaat caaaacggga agtgaagccc accgcctttt ccatcagttt     5820

ttcgcagaac ttcagcgttc ctgcaccttc acggggtgta aacaccggat tcgggttctt     5880

tacctggcgg taatacgttt ggtgaagatc agtcacacca tcctgcactt acaatgcgca     5940

gaaggagcga gcacagaaag aagtcttgaa cttttccggg catataacta tactccccgc     6000

atagctgaat tgttggctat acggtttaag tgggccccgg taatcttttc gtactcgcaa     6060

aagttgaaga agattatcgg ggtttttgct tttctggctc ctgtaaatcc acatcagaac     6120

cagttccttg ccaccttacg gcgtggccag ccacaaaatt ccttaaacga tcagtaatct     6180

agcactaatc ttctgaacac tcaagaatgt aagcccatca tcacatgcat cgttttgcgc     6240

ttcacttttt atcagtgcgg tcagaacttc agcctgagtc agaccatctt catgacacat     6300

ttgcatgagc atggccttat actttggttc aagaaatact tttacttcct tgaacgaagc     6360

tcttttacgg gccactgata atctttgttt ctctgcatca gaaagcggat tcccctttct     6420

gtatgctcgt tttgcgccag atgaggaagt cactgcattt tctgtctgcg acatctcgcc     6480

tcctcaatac tcaaacaggg atcgtttcgc agaggatact acagtttttt gaaatcagcg     6540

acttgagaat tgtgacgaag atctgtgttg gcgcacaaat caacggggat tactgtcgtt     6600

taatgtgatt taaactgtga aatagtatgg ttttcagtta ttgaaacgcc gggagcgggg     6660

aaaacttgct ttttcccgtt tccggggttg gacaactgag caacgcgaag gcgtcagcta     6720

cgatgttccg gggactgctg atcagcccct gttgtattca gccattctcc ggtcatccga     6780

acgccagcaa gacgtagccc agcgcgtcgg ccaattcgcg ctaacttaca ttaattgcgt     6840

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg     6900

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgcca gggtggtttt tcttttcacc     6960

agtgagacgg gcaacagctg attgcccttc accgcctggc cctgagagag ttgcagcaag     7020

cggtccacgc tggtttgccc cagcaggcga aaatcctgtt tgatggtggt tgacggcggg     7080

atataacatg agctgtcttc ggtatcgtcg tatcccacta ccgagatatc cgcaccaacg     7140

cgcagcccgg actcggtaat ggcgcgcatt gcgcccagcg ccatctgatc gttggcaacc     7200

agcatcgcag tgggaacgat gccctcattc agcatttgca tggtttgttg aaaaccggac     7260

atggcactcc agtcgccttc ccgttccgct atcggctgaa tttgattgcg agtgagatat     7320

ttatgccagc cagccagacg cagacgcgcc gagacagaac ttaatgggcc cgctaacagc     7380

gcgatttgct ggtgacccaa tgcgaccaga tgctccacgc ccagtcgcgt accgtcttca     7440

tgggagaaaa taatactgtt gatgggtgtc tggtcagaga catcaagaaa taacgccgga     7500

acattagtgc aggcagcttc cacagcaatg gcatcctggt catccagcgg atagttaatg     7560

atcagcccac tgacgcgttg cgcgagaaga ttgtgcaccg ccgctttaca ggcttcgacg     7620

ccgcttcgtt ctaccatcga caccaccacg ctggcaccca gttgatcggc gcgagattta     7680

atcgccgcga caatttgcga cggcgcgtgc agggccagac tggaggtggc aacgccaatc     7740

agcaacgact gtttgcccgc cagttgttgt gccacgcggt tgggaatgta attcagctcc     7800

gccatcgccg cttccacttt ttcccgcgtt ttcgcagaaa cgtggctggc ctggttcacc     7860

acgcgggaaa cggtctgata agagacaccg gcatactctg cgacatcgta taacgttact     7920

ggtttcacat tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga     7980

aaggttttgc accattcgat ggtgtcaacg taaatgcatg ccgcttcgcc ttcgcgcgcg     8040

aattggccgc catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac     8100

cagtgacgaa ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga     8160

tcatcgtcgc gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca     8220

cctgtcctac gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc     8280

cccgcgccca ccggaaggag ctgactgggt tgaaggctct caagggcatc ggcggagctt     8340

atcgactgca cggtgcacca atgcttctgg cgtcaggcag ccatcggaag ctgtggtatg     8400

gctgtgcagg tcgtaaatca ctgcataatt cgtgtcgctc aaggcgcact cccgttctgg     8460

ataatgtttt ttgcgccgac atcataacgg ttctggcaaa tattctgaaa tgagctgttg     8520

acaattaatc atcggctcgt ataatgtgtg gaattgtgag cggataacaa tttcacacag     8580

gaaacagaat tc                                                         8592


<210>  172
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Ec.Mdh

<400>  172
atgaaagtcg cagtcctcgg cgccgctggc ggtgtcggcc aggcgcttgc actactgtta       60

aaaacccaac tgccttcagg ttcagaactc tctctgtatg gcatcgctcc agtgactccc      120

ggtgtggctg tcgatctgag ccatatccct actgctgtga aaatcaaagg tttttctggt      180

gaagatgcga ctccggcgct ggaaggcgca gatgtcgttc ttatctctgc aggcgtagcg      240

gctaaaccgg gccagtctcg ttccgacctg tttaacgtta acgccggcat cgtgaaaaac      300

ctggtacagc aagttgcgaa aacctgcccg aaagcgtgca ttggtattat cactaacccg      360

gttaacacca cagttgcaat tgctgctgaa gtgctgaaaa aagccggtgt ttatgacaaa      420

aacaaactgt tcggcgttac cacgctggat atcattcgtt ccaacacctt tgttgcggaa      480

ctgaaaggca aacagccagg cgaagttgaa gtgccggtta ttggcggcca ctctgatgtt      540

accattctgc cgctgctgtc acaggttcct ggcgttagtt ttaccgagca ggaagtggct      600

gatctgacca aacgcatcca gaacgcgggt actgaagtgg ttgaagcgaa ggccggtggc      660

gggtctgcaa ccctgtctat gggccaggca gctgcacgtt ttggtctgtc tctggttcgt      720

gcactgcagg gcgaacaagg cgttgtcgaa tgtgcctacg ttgaaggcga cggtcagtac      780

gcccgtttct tctctcaacc gctgctgctg ggtaaaaacg gcgtggaaga gcgtaaatct      840

atcggtaccc tgagcgcatt tgaacagaac gcgctggaag gtatgctgga tacgctgaag      900

aaagatatcg ccctgggcga agagttcgtt aataagtaa                             939


<210>  173
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Ec.Mdh mit den Mutationen I12V R81A M85Q D86S G179D 
       D34G

<400>  173

Met Lys Val Ala Val Leu Gly Ala Ala Gly Gly Val Gly Gln Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Lys Thr Gln Leu Pro Ser Gly Ser Glu Leu Ser Leu 
            20                  25                  30          


Tyr Gly Ile Ala Pro Val Thr Pro Gly Val Ala Val Asp Leu Ser His 
        35                  40                  45              


Ile Pro Thr Ala Val Lys Ile Lys Gly Phe Ser Gly Glu Asp Ala Thr 
    50                  55                  60                  


Pro Ala Leu Glu Gly Ala Asp Val Val Leu Ile Ser Ala Gly Val Ala 
65                  70                  75                  80  


Ala Lys Pro Gly Gln Ser Arg Ser Asp Leu Phe Asn Val Asn Ala Gly 
                85                  90                  95      


Ile Val Lys Asn Leu Val Gln Gln Val Ala Lys Thr Cys Pro Lys Ala 
            100                 105                 110         


Cys Ile Gly Ile Ile Thr Asn Pro Val Asn Thr Thr Val Ala Ile Ala 
        115                 120                 125             


Ala Glu Val Leu Lys Lys Ala Gly Val Tyr Asp Lys Asn Lys Leu Phe 
    130                 135                 140                 


Gly Val Thr Thr Leu Asp Ile Ile Arg Ser Asn Thr Phe Val Ala Glu 
145                 150                 155                 160 


Leu Lys Gly Lys Gln Pro Gly Glu Val Glu Val Pro Val Ile Gly Gly 
                165                 170                 175     


His Ser Asp Val Thr Ile Leu Pro Leu Leu Ser Gln Val Pro Gly Val 
            180                 185                 190         


Ser Phe Thr Glu Gln Glu Val Ala Asp Leu Thr Lys Arg Ile Gln Asn 
        195                 200                 205             


Ala Gly Thr Glu Val Val Glu Ala Lys Ala Gly Gly Gly Ser Ala Thr 
    210                 215                 220                 


Leu Ser Met Gly Gln Ala Ala Ala Arg Phe Gly Leu Ser Leu Val Arg 
225                 230                 235                 240 


Ala Leu Gln Gly Glu Gln Gly Val Val Glu Cys Ala Tyr Val Glu Gly 
                245                 250                 255     


Asp Gly Gln Tyr Ala Arg Phe Phe Ser Gln Pro Leu Leu Leu Gly Lys 
            260                 265                 270         


Asn Gly Val Glu Glu Arg Lys Ser Ile Gly Thr Leu Ser Ala Phe Glu 
        275                 280                 285             


Gln Asn Ala Leu Glu Gly Met Leu Asp Thr Leu Lys Lys Asp Ile Ala 
    290                 295                 300                 


Leu Gly Glu Glu Phe Val Asn Lys 
305                 310         


<210>  174
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Ec.Mdh

<400>  174
atgaaagtcg cagtcctcgg cgctgctggc ggtgtcggcc aggcgcttgc actactgtta       60

aaaacccaac tgccttcagg ttcagaactc tctctgtatg attctgctcc agtgactccc      120

ggtgtggctg tcgatctgag ccatatccct actgctgtga aaatcaaagg tttttctggt      180

gaagatgcga ctccggcgct ggaaggcgca gatgtcgttc ttatctctgc aggcgtagcg      240

gctaaaccgg gtcagtctcg ttccgacctg tttaacgtta acgccggcat cgtgaaaaac      300

ctggtacagc aagttgcgaa aacctgcccg aaagcgtgca ttggtattat cactaacccg      360

gttaacacca cagttgcaat tgctgctgaa gtgctgaaaa aagccggtgt ttatgacaaa      420

aacaaactgt tcggcgttac cacgctggat atcattcgtt ccaacacctt tgttgcggaa      480

ctgaaaggca aacagccagg cgaagttgaa gtgccggtta ttggcggtca ctctgatgtt      540

accattctgc cgctgctgtc acaggttcct ggcgttagtt ttaccgagca ggaagtggct      600

gatctgacca aacgcatcca gaacgcgggt actgaagtgg ttgaagcgaa ggccggtggc      660

gggtctgcaa ccctgtctat gggccaggca gctgcacgtt ttggtctgtc tctggttcgt      720

gcactgcagg gcgaacaagg cgttgtcgaa tgtgcctacg ttgaaggcga cggtcagtac      780

gcccgtttct tctctcaacc gctgctgctg ggtaaaaacg gcgtggaaga gcgtaaatct      840

atcggtaccc tgagcgcatt tgaacagaac gcgctggaag gtatgctgga tacgctgaag      900

aaagatatcg ccctgggcga agagttcgtt aataagtaa                             939


<210>  175
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Ec.Mdh mit den Mutationen I12V R81A M85Q D86S G179D 
       I35S

<400>  175

Met Lys Val Ala Val Leu Gly Ala Ala Gly Gly Val Gly Gln Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Lys Thr Gln Leu Pro Ser Gly Ser Glu Leu Ser Leu 
            20                  25                  30          


Tyr Asp Ser Ala Pro Val Thr Pro Gly Val Ala Val Asp Leu Ser His 
        35                  40                  45              


Ile Pro Thr Ala Val Lys Ile Lys Gly Phe Ser Gly Glu Asp Ala Thr 
    50                  55                  60                  


Pro Ala Leu Glu Gly Ala Asp Val Val Leu Ile Ser Ala Gly Val Ala 
65                  70                  75                  80  


Ala Lys Pro Gly Gln Ser Arg Ser Asp Leu Phe Asn Val Asn Ala Gly 
                85                  90                  95      


Ile Val Lys Asn Leu Val Gln Gln Val Ala Lys Thr Cys Pro Lys Ala 
            100                 105                 110         


Cys Ile Gly Ile Ile Thr Asn Pro Val Asn Thr Thr Val Ala Ile Ala 
        115                 120                 125             


Ala Glu Val Leu Lys Lys Ala Gly Val Tyr Asp Lys Asn Lys Leu Phe 
    130                 135                 140                 


Gly Val Thr Thr Leu Asp Ile Ile Arg Ser Asn Thr Phe Val Ala Glu 
145                 150                 155                 160 


Leu Lys Gly Lys Gln Pro Gly Glu Val Glu Val Pro Val Ile Gly Gly 
                165                 170                 175     


His Ser Asp Val Thr Ile Leu Pro Leu Leu Ser Gln Val Pro Gly Val 
            180                 185                 190         


Ser Phe Thr Glu Gln Glu Val Ala Asp Leu Thr Lys Arg Ile Gln Asn 
        195                 200                 205             


Ala Gly Thr Glu Val Val Glu Ala Lys Ala Gly Gly Gly Ser Ala Thr 
    210                 215                 220                 


Leu Ser Met Gly Gln Ala Ala Ala Arg Phe Gly Leu Ser Leu Val Arg 
225                 230                 235                 240 


Ala Leu Gln Gly Glu Gln Gly Val Val Glu Cys Ala Tyr Val Glu Gly 
                245                 250                 255     


Asp Gly Gln Tyr Ala Arg Phe Phe Ser Gln Pro Leu Leu Leu Gly Lys 
            260                 265                 270         


Asn Gly Val Glu Glu Arg Lys Ser Ile Gly Thr Leu Ser Ala Phe Glu 
        275                 280                 285             


Gln Asn Ala Leu Glu Gly Met Leu Asp Thr Leu Lys Lys Asp Ile Ala 
    290                 295                 300                 


Leu Gly Glu Glu Phe Val Asn Lys 
305                 310         


<210>  176
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Ec.Mdh

<400>  176
atgaaagtcg cagtcctcgg cgccgctggc ggtgtcggcc aggcgcttgc actactgtta       60

aaaacccaac tgccttcagg ttcagaactc tctctgtatg gcaaagctcc agtgactccc      120

ggtgtggctg tcgatctgag ccatatccct actgctgtga aaatcaaagg tttttctggt      180

gaagatgcga ctccggcgct ggaaggcgca gatgtcgttc ttatctctgc aggcgtagcg      240

gctaaaccgg gccagtctcg ttccgacctg tttaacgtta acgccggcat cgtgaaaaac      300

ctggtacagc aagttgcgaa aacctgcccg aaagcgtgca ttggtattat cactaacccg      360

gttaacacca cagttgcaat tgctgctgaa gtgctgaaaa aagccggtgt ttatgacaaa      420

aacaaactgt tcggcgttac cacgctggat atcattcgtt ccaacacctt tgttgcggaa      480

ctgaaaggca aacagccagg cgaagttgaa gtgccggtta ttggcggcca ctctgatgtt      540

accattctgc cgctgctgtc acaggttcct ggcgttagtt ttaccgagca ggaagtggct      600

gatctgacca aacgcatcca gaacgcgggt actgaagtgg ttgaagcgaa ggccggtggc      660

gggtctgcaa ccctgtctat gggccaggca gctgcacgtt ttggtctgtc tctggttcgt      720

gcactgcagg gcgaacaagg cgttgtcgaa tgtgcctacg ttgaaggcga cggtcagtac      780

gcccgtttct tctctcaacc gctgctgctg ggtaaaaacg gcgtggaaga gcgtaaatct      840

atcggtaccc tgagcgcatt tgaacagaac gcgctggaag gtatgctgga tacgctgaag      900

aaagatatcg ccctgggcga agagttcgtt aataagtaa                             939


<210>  177
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Ec.Mdh mit den Mutationen I12V R81A M85Q D86S G179D 
       D34G I35K

<400>  177

Met Lys Val Ala Val Leu Gly Ala Ala Gly Gly Val Gly Gln Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Lys Thr Gln Leu Pro Ser Gly Ser Glu Leu Ser Leu 
            20                  25                  30          


Tyr Gly Lys Ala Pro Val Thr Pro Gly Val Ala Val Asp Leu Ser His 
        35                  40                  45              


Ile Pro Thr Ala Val Lys Ile Lys Gly Phe Ser Gly Glu Asp Ala Thr 
    50                  55                  60                  


Pro Ala Leu Glu Gly Ala Asp Val Val Leu Ile Ser Ala Gly Val Ala 
65                  70                  75                  80  


Ala Lys Pro Gly Gln Ser Arg Ser Asp Leu Phe Asn Val Asn Ala Gly 
                85                  90                  95      


Ile Val Lys Asn Leu Val Gln Gln Val Ala Lys Thr Cys Pro Lys Ala 
            100                 105                 110         


Cys Ile Gly Ile Ile Thr Asn Pro Val Asn Thr Thr Val Ala Ile Ala 
        115                 120                 125             


Ala Glu Val Leu Lys Lys Ala Gly Val Tyr Asp Lys Asn Lys Leu Phe 
    130                 135                 140                 


Gly Val Thr Thr Leu Asp Ile Ile Arg Ser Asn Thr Phe Val Ala Glu 
145                 150                 155                 160 


Leu Lys Gly Lys Gln Pro Gly Glu Val Glu Val Pro Val Ile Gly Gly 
                165                 170                 175     


His Ser Asp Val Thr Ile Leu Pro Leu Leu Ser Gln Val Pro Gly Val 
            180                 185                 190         


Ser Phe Thr Glu Gln Glu Val Ala Asp Leu Thr Lys Arg Ile Gln Asn 
        195                 200                 205             


Ala Gly Thr Glu Val Val Glu Ala Lys Ala Gly Gly Gly Ser Ala Thr 
    210                 215                 220                 


Leu Ser Met Gly Gln Ala Ala Ala Arg Phe Gly Leu Ser Leu Val Arg 
225                 230                 235                 240 


Ala Leu Gln Gly Glu Gln Gly Val Val Glu Cys Ala Tyr Val Glu Gly 
                245                 250                 255     


Asp Gly Gln Tyr Ala Arg Phe Phe Ser Gln Pro Leu Leu Leu Gly Lys 
            260                 265                 270         


Asn Gly Val Glu Glu Arg Lys Ser Ile Gly Thr Leu Ser Ala Phe Glu 
        275                 280                 285             


Gln Asn Ala Leu Glu Gly Met Leu Asp Thr Leu Lys Lys Asp Ile Ala 
    290                 295                 300                 


Leu Gly Glu Glu Phe Val Asn Lys 
305                 310         


<210>  178
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Ec.Mdh

<400>  178
atgaaagtcg cagtcctcgg cgccgctggc ggtgtcggcc aggcgcttgc actactgtta       60

aaaacccaac tgccttcagg ttcagaactc tctctgtatg gccgtgctcc agtgactccc      120

ggtgtggctg tcgatctgag ccatatccct actgctgtga aaatcaaagg tttttctggt      180

gaagatgcga ctccggcgct ggaaggcgca gatgtcgttc ttatctctgc aggcgtagcg      240

gctaaaccgg gccagtctcg ttccgacctg tttaacgtta acgccggcat cgtgaaaaac      300

ctggtacagc aagttgcgaa aacctgcccg aaagcgtgca ttggtattat cactaacccg      360

gttaacacca cagttgcaat tgctgctgaa gtgctgaaaa aagccggtgt ttatgacaaa      420

aacaaactgt tcggcgttac cacgctggat atcattcgtt ccaacacctt tgttgcggaa      480

ctgaaaggca aacagccagg cgaagttgaa gtgccggtta ttggcggcca ctctgatgtt      540

accattctgc cgctgctgtc acaggttcct ggcgttagtt ttaccgagca ggaagtggct      600

gatctgacca aacgcatcca gaacgcgggt actgaagtgg ttgaagcgaa ggccggtggc      660

gggtctgcaa ccctgtctat gggccaggca gctgcacgtt ttggtctgtc tctggttcgt      720

gcactgcagg gcgaacaagg cgttgtcgaa tgtgcctacg ttgaaggcga cggtcagtac      780

gcccgtttct tctctcaacc gctgctgctg ggtaaaaacg gcgtggaaga gcgtaaatct      840

atcggtaccc tgagcgcatt tgaacagaac gcgctggaag gtatgctgga tacgctgaag      900

aaagatatcg ccctgggcga agagttcgtt aataagtaa                             939


<210>  179
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Ec.Mdh mit den Mutationen I12V R81A M85Q D86S G179D 
       D34G I35R

<400>  179

Met Lys Val Ala Val Leu Gly Ala Ala Gly Gly Val Gly Gln Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Lys Thr Gln Leu Pro Ser Gly Ser Glu Leu Ser Leu 
            20                  25                  30          


Tyr Gly Arg Ala Pro Val Thr Pro Gly Val Ala Val Asp Leu Ser His 
        35                  40                  45              


Ile Pro Thr Ala Val Lys Ile Lys Gly Phe Ser Gly Glu Asp Ala Thr 
    50                  55                  60                  


Pro Ala Leu Glu Gly Ala Asp Val Val Leu Ile Ser Ala Gly Val Ala 
65                  70                  75                  80  


Ala Lys Pro Gly Gln Ser Arg Ser Asp Leu Phe Asn Val Asn Ala Gly 
                85                  90                  95      


Ile Val Lys Asn Leu Val Gln Gln Val Ala Lys Thr Cys Pro Lys Ala 
            100                 105                 110         


Cys Ile Gly Ile Ile Thr Asn Pro Val Asn Thr Thr Val Ala Ile Ala 
        115                 120                 125             


Ala Glu Val Leu Lys Lys Ala Gly Val Tyr Asp Lys Asn Lys Leu Phe 
    130                 135                 140                 


Gly Val Thr Thr Leu Asp Ile Ile Arg Ser Asn Thr Phe Val Ala Glu 
145                 150                 155                 160 


Leu Lys Gly Lys Gln Pro Gly Glu Val Glu Val Pro Val Ile Gly Gly 
                165                 170                 175     


His Ser Asp Val Thr Ile Leu Pro Leu Leu Ser Gln Val Pro Gly Val 
            180                 185                 190         


Ser Phe Thr Glu Gln Glu Val Ala Asp Leu Thr Lys Arg Ile Gln Asn 
        195                 200                 205             


Ala Gly Thr Glu Val Val Glu Ala Lys Ala Gly Gly Gly Ser Ala Thr 
    210                 215                 220                 


Leu Ser Met Gly Gln Ala Ala Ala Arg Phe Gly Leu Ser Leu Val Arg 
225                 230                 235                 240 


Ala Leu Gln Gly Glu Gln Gly Val Val Glu Cys Ala Tyr Val Glu Gly 
                245                 250                 255     


Asp Gly Gln Tyr Ala Arg Phe Phe Ser Gln Pro Leu Leu Leu Gly Lys 
            260                 265                 270         


Asn Gly Val Glu Glu Arg Lys Ser Ile Gly Thr Leu Ser Ala Phe Glu 
        275                 280                 285             


Gln Asn Ala Leu Glu Gly Met Leu Asp Thr Leu Lys Lys Asp Ile Ala 
    290                 295                 300                 


Leu Gly Glu Glu Phe Val Asn Lys 
305                 310         


<210>  180
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Ec.Mdh

<400>  180
atgaaagtcg cagtcctcgg cgccgctggc ggtgtcggcc aggcgcttgc actactgtta       60

aaaacccaac tgccttcagg ttcagaactc tctctgtatg gctctgctcc agtgactccc      120

ggtgtggctg tcgatctgag ccatatccct actgctgtga aaatcaaagg tttttctggt      180

gaagatgcga ctccggcgct ggaaggcgca gatgtcgttc ttatctctgc aggcgtagcg      240

gctaaaccgg gccagtctcg ttccgacctg tttaacgtta acgccggcat cgtgaaaaac      300

ctggtacagc aagttgcgaa aacctgcccg aaagcgtgca ttggtattat cactaacccg      360

gttaacacca cagttgcaat tgctgctgaa gtgctgaaaa aagccggtgt ttatgacaaa      420

aacaaactgt tcggcgttac cacgctggat atcattcgtt ccaacacctt tgttgcggaa      480

ctgaaaggca aacagccagg cgaagttgaa gtgccggtta ttggcggcca ctctgatgtt      540

accattctgc cgctgctgtc acaggttcct ggcgttagtt ttaccgagca ggaagtggct      600

gatctgacca aacgcatcca gaacgcgggt actgaagtgg ttgaagcgaa ggccggtggc      660

gggtctgcaa ccctgtctat gggccaggca gctgcacgtt ttggtctgtc tctggttcgt      720

gcactgcagg gcgaacaagg cgttgtcgaa tgtgcctacg ttgaaggcga cggtcagtac      780

gcccgtttct tctctcaacc gctgctgctg ggtaaaaacg gcgtggaaga gcgtaaatct      840

atcggtaccc tgagcgcatt tgaacagaac gcgctggaag gtatgctgga tacgctgaag      900

aaagatatcg ccctgggcga agagttcgtt aataagtaa                             939


<210>  181
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Ec.Mdh mit den Mutationen I12V R81A M85Q D86S G179D 
       D34G I35S

<400>  181

Met Lys Val Ala Val Leu Gly Ala Ala Gly Gly Val Gly Gln Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Lys Thr Gln Leu Pro Ser Gly Ser Glu Leu Ser Leu 
            20                  25                  30          


Tyr Gly Ser Ala Pro Val Thr Pro Gly Val Ala Val Asp Leu Ser His 
        35                  40                  45              


Ile Pro Thr Ala Val Lys Ile Lys Gly Phe Ser Gly Glu Asp Ala Thr 
    50                  55                  60                  


Pro Ala Leu Glu Gly Ala Asp Val Val Leu Ile Ser Ala Gly Val Ala 
65                  70                  75                  80  


Ala Lys Pro Gly Gln Ser Arg Ser Asp Leu Phe Asn Val Asn Ala Gly 
                85                  90                  95      


Ile Val Lys Asn Leu Val Gln Gln Val Ala Lys Thr Cys Pro Lys Ala 
            100                 105                 110         


Cys Ile Gly Ile Ile Thr Asn Pro Val Asn Thr Thr Val Ala Ile Ala 
        115                 120                 125             


Ala Glu Val Leu Lys Lys Ala Gly Val Tyr Asp Lys Asn Lys Leu Phe 
    130                 135                 140                 


Gly Val Thr Thr Leu Asp Ile Ile Arg Ser Asn Thr Phe Val Ala Glu 
145                 150                 155                 160 


Leu Lys Gly Lys Gln Pro Gly Glu Val Glu Val Pro Val Ile Gly Gly 
                165                 170                 175     


His Ser Asp Val Thr Ile Leu Pro Leu Leu Ser Gln Val Pro Gly Val 
            180                 185                 190         


Ser Phe Thr Glu Gln Glu Val Ala Asp Leu Thr Lys Arg Ile Gln Asn 
        195                 200                 205             


Ala Gly Thr Glu Val Val Glu Ala Lys Ala Gly Gly Gly Ser Ala Thr 
    210                 215                 220                 


Leu Ser Met Gly Gln Ala Ala Ala Arg Phe Gly Leu Ser Leu Val Arg 
225                 230                 235                 240 


Ala Leu Gln Gly Glu Gln Gly Val Val Glu Cys Ala Tyr Val Glu Gly 
                245                 250                 255     


Asp Gly Gln Tyr Ala Arg Phe Phe Ser Gln Pro Leu Leu Leu Gly Lys 
            260                 265                 270         


Asn Gly Val Glu Glu Arg Lys Ser Ile Gly Thr Leu Ser Ala Phe Glu 
        275                 280                 285             


Gln Asn Ala Leu Glu Gly Met Leu Asp Thr Leu Lys Lys Asp Ile Ala 
    290                 295                 300                 


Leu Gly Glu Glu Phe Val Asn Lys 
305                 310         


<210>  182
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Mutante der Ec.Mdh

<400>  182
atgaaagtcg cagtcctcgg cgccgctggc ggtgtcggcc aggcgcttgc actactgtta       60

aaaacccaac tgccttcagg ttcagaactc tctctgtatg gcaccgctcc agtgactccc      120

ggtgtggctg tcgatctgag ccatatccct actgctgtga aaatcaaagg tttttctggt      180

gaagatgcga ctccggcgct ggaaggcgca gatgtcgttc ttatctctgc aggcgtagcg      240

gctaaaccgg gccagtctcg ttccgacctg tttaacgtta acgccggcat cgtgaaaaac      300

ctggtacagc aagttgcgaa aacctgcccg aaagcgtgca ttggtattat cactaacccg      360

gttaacacca cagttgcaat tgctgctgaa gtgctgaaaa aagccggtgt ttatgacaaa      420

aacaaactgt tcggcgttac cacgctggat atcattcgtt ccaacacctt tgttgcggaa      480

ctgaaaggca aacagccagg cgaagttgaa gtgccggtta ttggcggcca ctctgatgtt      540

accattctgc cgctgctgtc acaggttcct ggcgttagtt ttaccgagca ggaagtggct      600

gatctgacca aacgcatcca gaacgcgggt actgaagtgg ttgaagcgaa ggccggtggc      660

gggtctgcaa ccctgtctat gggccaggca gctgcacgtt ttggtctgtc tctggttcgt      720

gcactgcagg gcgaacaagg cgttgtcgaa tgtgcctacg ttgaaggcga cggtcagtac      780

gcccgtttct tctctcaacc gctgctgctg ggtaaaaacg gcgtggaaga gcgtaaatct      840

atcggtaccc tgagcgcatt tgaacagaac gcgctggaag gtatgctgga tacgctgaag      900

aaagatatcg ccctgggcga agagttcgtt aataagtaa                             939


<210>  183
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutante der Ec.Mdh mit den Mutationen I12V R81A M85Q D86S G179D 
       D34G I35T

<400>  183

Met Lys Val Ala Val Leu Gly Ala Ala Gly Gly Val Gly Gln Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Lys Thr Gln Leu Pro Ser Gly Ser Glu Leu Ser Leu 
            20                  25                  30          


Tyr Gly Thr Ala Pro Val Thr Pro Gly Val Ala Val Asp Leu Ser His 
        35                  40                  45              


Ile Pro Thr Ala Val Lys Ile Lys Gly Phe Ser Gly Glu Asp Ala Thr 
    50                  55                  60                  


Pro Ala Leu Glu Gly Ala Asp Val Val Leu Ile Ser Ala Gly Val Ala 
65                  70                  75                  80  


Ala Lys Pro Gly Gln Ser Arg Ser Asp Leu Phe Asn Val Asn Ala Gly 
                85                  90                  95      


Ile Val Lys Asn Leu Val Gln Gln Val Ala Lys Thr Cys Pro Lys Ala 
            100                 105                 110         


Cys Ile Gly Ile Ile Thr Asn Pro Val Asn Thr Thr Val Ala Ile Ala 
        115                 120                 125             


Ala Glu Val Leu Lys Lys Ala Gly Val Tyr Asp Lys Asn Lys Leu Phe 
    130                 135                 140                 


Gly Val Thr Thr Leu Asp Ile Ile Arg Ser Asn Thr Phe Val Ala Glu 
145                 150                 155                 160 


Leu Lys Gly Lys Gln Pro Gly Glu Val Glu Val Pro Val Ile Gly Gly 
                165                 170                 175     


His Ser Asp Val Thr Ile Leu Pro Leu Leu Ser Gln Val Pro Gly Val 
            180                 185                 190         


Ser Phe Thr Glu Gln Glu Val Ala Asp Leu Thr Lys Arg Ile Gln Asn 
        195                 200                 205             


Ala Gly Thr Glu Val Val Glu Ala Lys Ala Gly Gly Gly Ser Ala Thr 
    210                 215                 220                 


Leu Ser Met Gly Gln Ala Ala Ala Arg Phe Gly Leu Ser Leu Val Arg 
225                 230                 235                 240 


Ala Leu Gln Gly Glu Gln Gly Val Val Glu Cys Ala Tyr Val Glu Gly 
                245                 250                 255     


Asp Gly Gln Tyr Ala Arg Phe Phe Ser Gln Pro Leu Leu Leu Gly Lys 
            260                 265                 270         


Asn Gly Val Glu Glu Arg Lys Ser Ile Gly Thr Leu Ser Ala Phe Glu 
        275                 280                 285             


Gln Asn Ala Leu Glu Gly Met Leu Asp Thr Leu Lys Lys Asp Ile Ala 
    290                 295                 300                 


Leu Gly Glu Glu Phe Val Asn Lys 
305                 310         


<210>  184
<211>  8592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenz fr Plasmid

<400>  184
gagctcgttt aactttaaga aggagatata ccatgaaagt cgcagtcctc ggcgccgctg       60

gcggtgtcgg ccaggcgctt gcactactgt taaaaaccca actgccttca ggttcagaac      120

tctctctgta tggccgtgct ccagtgactc ccggtgtggc tgtcgatctg agccatatcc      180

ctactgctgt gaaaatcaaa ggtttttctg gtgaagatgc gactccggcg ctggaaggcg      240

cagatgtcgt tcttatctct gcaggcgtag cggctaaacc gggccagtct cgttccgacc      300

tgtttaacgt taacgccggc atcgtgaaaa acctggtaca gcaagttgcg aaaacctgcc      360

cgaaagcgtg cattggtatt atcactaacc cggttaacac cacagttgca attgctgctg      420

aagtgctgaa aaaagccggt gtttatgaca aaaacaaact gttcggcgtt accacgctgg      480

atatcattcg ttccaacacc tttgttgcgg aactgaaagg caaacagcca ggcgaagttg      540

aagtgccggt tattggcggc cactctgatg ttaccattct gccgctgctg tcacaggttc      600

ctggcgttag ttttaccgag caggaagtgg ctgatctgac caaacgcatc cagaacgcgg      660

gtactgaagt ggttgaagcg aaggccggtg gcgggtctgc aaccctgtct atgggccagg      720

cagctgcacg ttttggtctg tctctggttc gtgcactgca gggcgaacaa ggcgttgtcg      780

aatgtgccta cgttgaaggc gacggtcagt acgcccgttt cttctctcaa ccgctgctgc      840

tgggtaaaaa cggcgtggaa gagcgtaaat ctatcggtac cctgagcgca tttgaacaga      900

acgcgctgga aggtatgctg gatacgctga agaaagatat cgccctgggc gaagagttcg      960

ttaataagta aggatccgtt taactttaag aaggagatat accatgaaag ccaactctcc     1020

cgtcatccgc ctgaacccgg tcgatgatgt cgtcatcgcc cgccagcagc tcatctccgg     1080

caccgtgctg caggacgaag gcggcctcaa agtccagggc ctcattcccg ccggccacaa     1140

gatggcgacc cgcgccatct ctgcgggcga gccggtcaag cgctatggcc agatcatcgg     1200

cacggccagc caggacatcg cgcccggaca gcacgtgcac acgcacaacc tggccatggc     1260

cgagttctcg cgtgaacacc atttcggcgc tgacgtgaag ccggtcgatt tcgtcgccga     1320

gcccgcaacc ttcatgggca tcgtgcgtcc cgatggccgc gtggccacgc gcaactacat     1380

cggcgtactg acctcggtga actgctcggc caccgcggca cgcgccatcg ccgattactt     1440

ccgccgcgac atccatcccg aagtgctggc cgactatccc aacatcgatg gcgtggtggc     1500

cctgacccat ggccagggtt gcgccacgga ttcgcagggc gagccgctgc agatcctgcg     1560

ccgcacgctg gcgggttacg ccacgcatcc caacttcgct gcggtgctgg tggtgggcct     1620

gggctgcgag accaaccaga tctcgggcct gatggaaagc cacaacctga aggaaggcga     1680

atacttccac accttcacca tccagggcac cggcggcacc gccaagaccg tggcgctggg     1740

gatcgagaag atcaagaaga tgctgcccaa ggccaatgac atcaagcgcg agccggtgtc     1800

ggccaagcat ctgacgctgg gcctgcagtg cggtggttcg gatggctatt cgggcatcac     1860

ggccaatccg gcgctgggtg cggcagtgga cttgctggtg cggcatggcg gcacggccat     1920

cctttccgaa acgccggaaa tctatggggc cgaacacctg ctcacccgcc gcgcggtctc     1980

gccggaagtc ggtgagaagc tgctggcccg catcgcctgg tgggaggagt attgcgccaa     2040

gaacgatgcc gagatgaaca acaatccctc agcgggcaac aaggccggtg gcttgaccac     2100

catcctcgag aagtcgctgg gcgcggttgc caagggtggc actaccaatc tggtggatgt     2160

ctacaagtat gcggagacgg tcaccgcacg cggcttcgtc ttcatggata cgccgggcta     2220

cgacccgatc tccgccaccg gccaggtcgc cggaggggcc aacatgatct gcttcaccac     2280

gggccggggt tctgcctatg gctgcgcacc ggcaccgtcg ctcaagctgg ccaccaatac     2340

tgcgctgtgg caacgtcagg aagaagacat ggatatcaac tgcggcgaga ttgccgacag     2400

caatgtcacc ccgcaggagg tcggcgaacg cttcttccag atgatcctcg atacggcatc     2460

gggcaagaag accaagagcg agctgcatgg ctacgggcaa gacgaattcg tgccctggca     2520

catcggcgtc tacacctgat ctagagtcga cctgcaggca tgcaagcttc tgttttggcg     2580

gatgagagaa gaaattcgtc gcccgccata aactgccagg catcaaatta agcagaaggc     2640

catcctgacg gatggccttt ttgcgtttct acaaactctt cctgtctagc aggtggcact     2700

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     2760

tatccgctca tgagcttcac gctgccgcaa gcactcaggg cgcaagggct gctaaaggaa     2820

gcggaacacg tagaaagcca gtccgcagaa acggtgctga ccccggatga atgtcagcta     2880

ctgggctatc tggacaaggg aaaacgcaag cgcaaagaga aagcaggtag cttgcagtgg     2940

gcttacatgg cgatagctag actgggcggt tttatggaca gcaagcgaac cggaattgcc     3000

agctggggcg ccctctggta aggttgggaa gccctgcaaa gtaaactgga tggctttctt     3060

gccgccaagg atctgatggc gcaggggatc aagatctgat caagagacag gatgaggatc     3120

gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag     3180

gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg     3240

gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa     3300

tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc     3360

agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc     3420

ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga     3480

tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa     3540

acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct     3600

ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgcgcat     3660

gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt     3720

ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta     3780

tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga     3840

ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg     3900

ccttcttgac gagttcttct gagcgggact ctggggttcg aaatgaccga ccaagcgacg     3960

cccaacctgc catcacgaga tttcgattcc accgccgcct tctatgaaag gttgggcttc     4020

ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct catgctggag     4080

ttcttcgccc accccgatat tgattacgtg tttgaatcat tgcatcgcct gtaaattttt     4140

aacttgtcct atttttgtca ttaccacgta tatacacatg tataacaatt cagatatcgt     4200

taccaggata tgccgcatca gcggcatgga aggcggcact ctgttgtttc atatgataca     4260

ggagtaaaac cgccgaagcc cggcgtaagc cggtactgat tgatagattt caccttaccc     4320

atccccagcc ctgccagacc atacccgctt tcagccatga gagagcttct gtgcgcggtc     4380

ggagtggtcc cgacgagggt ttacccgaag tcggggcgta tctccgcgtt agcgggccgt     4440

cagggccgct tacgagcgtg tactgagaac ttccagcgag aagactgaca gcgatgatga     4500

agtagttaca acattcataa ttaaaagcga ctctgttccg gcccttcggg ccggggcggg     4560

gccgcttttc agttatgagg gaggggcttt gtggtttcag ttctgcgctg gaccggggtt     4620

tttctggtgg ttgtgtctga gtgttgtaac taaagcggct ccggtagggg cccgccgctt     4680

gcggtgggag gtgcatatct gtctgtccac aggacaggca gtgaataggt tttcttttta     4740

aatgaatgta attaagtagt ttaaaggaga tataaacagg tgtttaaaag atacattgca     4800

ccctgtaacg ctggcggatg gcgctttatg acatgaacgg ttgtaacctt atggggaagt     4860

cccttgcagt ttaatgtgga taagcaaaat tccccgtctg tgaggcgtgt tttgtatcga     4920

aaacaggggg ggccggatgc accagaagct ggatgatgag gttgtttttt gtatgtggtg     4980

ctgatttttt gtgcgctgtc gggcttcaga cgtgcggaag cctccggcgc aggccggatt     5040

attcagagga ggtcactttc agggggaagc tgtggccagc cggctgtaat tacggttacg     5100

tgacagaatc atgcgctcct tcacacgacg ctcaacttcg cgttttaccg cctcacgatt     5160

ggcagtgaag cgcccttccg cgatttcgcg cgtcagctgc cgtttcacca gggtgacaat     5220

atcctgacgt tccctgtccg catcacgacg cgcacgggca cgctttattc cccgggactt     5280

aagctctgtc tgataactgc gaaaacgctc acgaacaaaa cgccaggctt tcgctatcag     5340

ttcatccatg cccagggtat ccagcccctg ctttttgcgt tgtttgtttt cccataccac     5400

acggctgcgg cgcgcggcgg ccactgcctc ctctgataca tcgagggcag caaacagtgc     5460

agatgtgaac gtgatatcgg tcggaatgta gcacccgata agcgggtcat attccgtctg     5520

gtaggtaatc agtcccagct ctgacaggaa cgtcagggcc cgggtggcac gggtgatgga     5580

gagttttccg gcagcagact ccgtcgccag tccgcactca atggccagcg tggtgatgga     5640

gcactggacg cggttggcca gcgggtcata gtggaaacac agcccctgca ggagcgcatc     5700

aatagcccgt cgacgcagca ctggtggcat gcgtcgacgc agaccacgcg aacgggcatg     5760

cgccacatga atggcgaaat caaaacggga agtgaagccc accgcctttt ccatcagttt     5820

ttcgcagaac ttcagcgttc ctgcaccttc acggggtgta aacaccggat tcgggttctt     5880

tacctggcgg taatacgttt ggtgaagatc agtcacacca tcctgcactt acaatgcgca     5940

gaaggagcga gcacagaaag aagtcttgaa cttttccggg catataacta tactccccgc     6000

atagctgaat tgttggctat acggtttaag tgggccccgg taatcttttc gtactcgcaa     6060

aagttgaaga agattatcgg ggtttttgct tttctggctc ctgtaaatcc acatcagaac     6120

cagttccttg ccaccttacg gcgtggccag ccacaaaatt ccttaaacga tcagtaatct     6180

agcactaatc ttctgaacac tcaagaatgt aagcccatca tcacatgcat cgttttgcgc     6240

ttcacttttt atcagtgcgg tcagaacttc agcctgagtc agaccatctt catgacacat     6300

ttgcatgagc atggccttat actttggttc aagaaatact tttacttcct tgaacgaagc     6360

tcttttacgg gccactgata atctttgttt ctctgcatca gaaagcggat tcccctttct     6420

gtatgctcgt tttgcgccag atgaggaagt cactgcattt tctgtctgcg acatctcgcc     6480

tcctcaatac tcaaacaggg atcgtttcgc agaggatact acagtttttt gaaatcagcg     6540

acttgagaat tgtgacgaag atctgtgttg gcgcacaaat caacggggat tactgtcgtt     6600

taatgtgatt taaactgtga aatagtatgg ttttcagtta ttgaaacgcc gggagcgggg     6660

aaaacttgct ttttcccgtt tccggggttg gacaactgag caacgcgaag gcgtcagcta     6720

cgatgttccg gggactgctg atcagcccct gttgtattca gccattctcc ggtcatccga     6780

acgccagcaa gacgtagccc agcgcgtcgg ccaattcgcg ctaacttaca ttaattgcgt     6840

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg     6900

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgcca gggtggtttt tcttttcacc     6960

agtgagacgg gcaacagctg attgcccttc accgcctggc cctgagagag ttgcagcaag     7020

cggtccacgc tggtttgccc cagcaggcga aaatcctgtt tgatggtggt tgacggcggg     7080

atataacatg agctgtcttc ggtatcgtcg tatcccacta ccgagatatc cgcaccaacg     7140

cgcagcccgg actcggtaat ggcgcgcatt gcgcccagcg ccatctgatc gttggcaacc     7200

agcatcgcag tgggaacgat gccctcattc agcatttgca tggtttgttg aaaaccggac     7260

atggcactcc agtcgccttc ccgttccgct atcggctgaa tttgattgcg agtgagatat     7320

ttatgccagc cagccagacg cagacgcgcc gagacagaac ttaatgggcc cgctaacagc     7380

gcgatttgct ggtgacccaa tgcgaccaga tgctccacgc ccagtcgcgt accgtcttca     7440

tgggagaaaa taatactgtt gatgggtgtc tggtcagaga catcaagaaa taacgccgga     7500

acattagtgc aggcagcttc cacagcaatg gcatcctggt catccagcgg atagttaatg     7560

atcagcccac tgacgcgttg cgcgagaaga ttgtgcaccg ccgctttaca ggcttcgacg     7620

ccgcttcgtt ctaccatcga caccaccacg ctggcaccca gttgatcggc gcgagattta     7680

atcgccgcga caatttgcga cggcgcgtgc agggccagac tggaggtggc aacgccaatc     7740

agcaacgact gtttgcccgc cagttgttgt gccacgcggt tgggaatgta attcagctcc     7800

gccatcgccg cttccacttt ttcccgcgtt ttcgcagaaa cgtggctggc ctggttcacc     7860

acgcgggaaa cggtctgata agagacaccg gcatactctg cgacatcgta taacgttact     7920

ggtttcacat tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga     7980

aaggttttgc accattcgat ggtgtcaacg taaatgcatg ccgcttcgcc ttcgcgcgcg     8040

aattggccgc catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac     8100

cagtgacgaa ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga     8160

tcatcgtcgc gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca     8220

cctgtcctac gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc     8280

cccgcgccca ccggaaggag ctgactgggt tgaaggctct caagggcatc ggcggagctt     8340

atcgactgca cggtgcacca atgcttctgg cgtcaggcag ccatcggaag ctgtggtatg     8400

gctgtgcagg tcgtaaatca ctgcataatt cgtgtcgctc aaggcgcact cccgttctgg     8460

ataatgtttt ttgcgccgac atcataacgg ttctggcaaa tattctgaaa tgagctgttg     8520

acaattaatc atcggctcgt ataatgtgtg gaattgtgag cggataacaa tttcacacag     8580

gaaacagaat tc                                                         8592


