﻿                         序列表

<110>  北京助天科技集团有限公司

<120>  一种嵌合抗原受体改造的NK细胞及其制备方法与应用

<130>  2022

<150>  2021100906020
<151>  2021-01-22

<160>  80

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  117
<212>  PRT
<213>  Artifical

<400>  1
Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn 
1               5                   10                  15      
Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
            20                  25                  30          
Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
        35                  40                  45              
Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
    50                  55                  60                  
Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
65                  70                  75                  80  
Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
                85                  90                  95      
Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110         
Glu Arg Arg Ala Glu 
        115         

<210>  2
<211>  351
<212>  DNA
<213>  Artifical

<400>  2
ccccccacct tctccccagc cctgctcgtg gtgaccgaag gggacaacgc caccttcacc        60
tgcagcttct ccaacacatc ggagagcttc gtgctaaact ggtaccgcat gagccccagc       120
aaccagacgg acaagctggc cgccttcccc gaggaccgca gccagcccgg ccaggactgc       180
cgcttccgtg tcacacaact gcccaacggg cgtgacttcc acatgagcgt ggtcagggcc       240
cggcgcaatg acagcggcac ctacctctgt ggggccatct ccctggcccc caaggcgcag       300
atcaaagaga gcctgcgggc agagctcagg gtgacagaga gaagggcaga a                351

<210>  3
<211>  110
<212>  PRT
<213>  Artifical

<400>  3
Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      
Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          
Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              
Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  
Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  
Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      
Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110 

<210>  4
<211>  330
<212>  DNA
<213>  Artifical

<400>  4
cccaccttct ccccagccct gctcgtggtg accgaagggg acaacgccac cttcacctgc        60
agcttctcca acacatcgga gagcttcgtg ctaaactggt accgcatgag ccccagcaac       120
cagacggaca agctggccgc cttccccgag gaccgcagcc agcccggcca ggactgccgc       180
ttccgtgtca cacaactgcc caacgggcgt gacttccaca tgagcgtggt cagggcccgg       240
cgcaatgaca gcggcaccta cctctgtggg gccatctccc tggcccccaa ggcgcagatc       300
aaagagagcc tgcgggcaga gctcagggtg                                        330

<210>  5
<211>  121
<212>  PRT
<213>  Artifical

<400>  5
Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      
Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          
Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              
Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  
Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  
Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      
Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         
Glu Ser Leu Arg Ala Glu Leu Arg Val 
        115                 120     

<210>  6
<211>  363
<212>  DNA
<213>  Artifical

<400>  6
ttcttagact ccccagacag gccctggaac ccccccacct tctccccagc cctgctcgtg        60
gtgaccgaag gggacaacgc caccttcacc tgcagcttct ccaacacatc ggagagcttc       120
gtgctaaact ggtaccgcat gagccccagc aaccagacgg acaagctggc cgccttcccc       180
gaggaccgca gccagcccgg ccaggactgc cgcttccgtg tcacacaact gcccaacggg       240
cgtgacttcc acatgagcgt ggtcagggcc cggcgcaatg acagcggcac ctacctctgt       300
ggggccatct ccctggcccc caaggcgcag atcaaagaga gcctgcgggc agagctcagg       360
gtg                                                                     363

<210>  7
<211>  251
<212>  PRT
<213>  Artifical

<400>  7
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Thr 
            20                  25                  30          
Lys Ala Ala Trp Tyr Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              
Trp Leu Gly Arg Thr Tyr Phe Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Ser Arg Leu Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  
Gln Phe Ser Leu Gln Leu Lys Ser Val Ser Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Arg Gly Gln Tyr Thr Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         
Gly Thr Met Val Thr Val Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 
Ile Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 
Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asp Leu Val Ser 
                165                 170                 175     
Trp Tyr Gln Gln Tyr Pro Gly Gln Ala Pro Arg Leu Ile Ile Tyr Glu 
            180                 185                 190         
Val Ile Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             
Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 
Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Arg Arg Leu His Gly 
225                 230                 235                 240 
Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
                245                 250     

<210>  8
<211>  753
<212>  DNA
<213>  Artifical

<400>  8
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc        60
acctgtgcca tctccgggga cagtgtctct agcaccaagg ctgcttggta ctggatcagg       120
cagtcccctt cgagaggcct tgagtggctg ggaaggacat acttccggtc caagtggtat       180
aatgactatg ccgactctgt gaaaagtcga ttaaccatca acccagacac atccaagaac       240
cagttctccc tgcaacttaa gtctgtgagt cccgaggaca cggctgtgta ttactgtgca       300
agagggcaat acactgcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca       360
ggaattctag gatccggtgg cggtggcagc ggcggtggtg gttccggagg cggcggttct       420
cagtctgctc tgattcagcc tgcctccgtg tctgggtccc ctggacagtc gatcactatc       480
tcctgtactg gcaccagtag tgatgttgga ggttatgacc ttgtctcctg gtaccaacag       540
tacccgggcc aagcccccag actcatcatt tatgaggtca ttaagcggcc ctcagggatt       600
tctgatcgct tctctggttc caagtctggc aacacggcct ccctgacaat ctctgggctc       660
caggctgagg acgaggctga ttattattgc tgctcatatg caggtagacg tcttcatggt       720
gtgttcggag gaggcaccca gctgaccgtc ctc                                    753

<210>  9
<211>  245
<212>  PRT
<213>  Artifical

<400>  9
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      
Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ile Met Met 
145                 150                 155                 160 
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                165                 170                 175     
Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val Lys Gly Arg 
            180                 185                 190         
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ile 
    210                 215                 220                 
Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 
Val Thr Val Ser Ser 
                245 

<210>  10
<211>  735
<212>  DNA
<213>  Artifical

<400>  10
cagtccgccc tgacccagcc tgcctccgtg tctggctccc ctggccagtc catcaccatc        60
agctgcaccg gcacctccag cgacgtgggc ggctacaact acgtgtcctg gtatcagcag       120
caccccggca aggcccccaa gctgatgatc tacgacgtgt ccaaccggcc ctccggcgtg       180
tccaacagat tctccggctc caagtccggc aacaccgcct ccctgaccat cagcggactg       240
caggcagagg acgaggccga ctactactgc tcctcctaca cctcctccag caccagagtg       300
ttcggcaccg gcacaaaagt gaccgtgctg ggagggggcg gttccggagg aggcggcagc       360
gggggaggag gtagcgaggt gcagctgctg gaatccggcg gaggactggt gcagcctggc       420
ggctccctga gactgtcttg cgccgcctcc ggcttcacct tctccagcta catcatgatg       480
tgggtgcgac aggcccctgg caagggcctg gaatgggtgt cctccatcta cccctccggc       540
ggcatcacct tctacgccga caccgtgaag ggccggttca ccatctcccg ggacaactcc       600
aagaacaccc tgtacctgca gatgaactcc ctgcgggccg aggacaccgc cgtgtactac       660
tgcgcccgga tcaagctggg caccgtgacc accgtggact actggggcca gggcaccctg       720
gtgacagtgt cctcc                                                        735

<210>  11
<211>  254
<212>  PRT
<213>  Artifical

<400>  11
Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Ser Leu 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Asn Tyr Gly Ser Ser Ser 
                85                  90                  95      
Ser Ser Ser Tyr Gly Ala Val Phe Gly Gln Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly 
145                 150                 155                 160 
Ile Asp Leu Ser Ser Tyr Thr Met Gly Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     
Lys Gly Leu Glu Trp Val Gly Ile Ile Ser Ser Gly Gly Arg Thr Tyr 
            180                 185                 190         
Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
        195                 200                 205             
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 
Ala Val Tyr Tyr Cys Ala Arg Gly Arg Tyr Thr Gly Tyr Pro Tyr Tyr 
225                 230                 235                 240 
Phe Ala Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 

<210>  12
<211>  21
<212>  PRT
<213>  Artifical

<400>  12
Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp 
1               5                   10                  15      
Val Leu Ala Val Ile 
            20      

<210>  13
<211>  63
<212>  DNA
<213>  Artifical

<400>  13
gttggtgtcg tgggcggcct gctgggcagc ctggtgctgc tagtctgggt cctggccgtc        60
atc                                                                      63

<210>  14
<211>  24
<212>  PRT
<213>  Artifical

<400>  14
Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu 
1               5                   10                  15      
Leu Val Trp Val Leu Ala Val Ile 
            20                  

<210>  15
<211>  72
<212>  DNA
<213>  Artifical

<400>  15
accctggtgg ttggtgtcgt gggcggcctg ctgggcagcc tggtgctgct agtctgggtc        60
ctggccgtca tc                                                            72

<210>  16
<211>  20
<212>  PRT
<213>  Artifical

<400>  16
Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe 
1               5                   10                  15      
Gln Thr Leu Val 
            20  

<210>  17
<211>  60
<212>  DNA
<213>  Artifical

<400>  17
gtgcccacag cccaccccag cccctcaccc aggccagccg gccagttcca aaccctggtg        60

<210>  18
<211>  23
<212>  PRT
<213>  Artifical

<400>  18
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
1               5                   10                  15      
Arg Pro Ala Gly Gln Phe Gln 
            20              

<210>  19
<211>  69
<212>  DNA
<213>  Artifical

<400>  19
acagagagaa gggcagaagt gcccacagcc caccccagcc cctcacccag gccagccggc        60
cagttccaa                                                                69

<210>  20
<211>  20
<212>  PRT
<213>  Artifical

<400>  20
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      
Val Leu Asp Lys 
            20  

<210>  21
<211>  60
<212>  DNA
<213>  Artifical

<400>  21
aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag        60

<210>  22
<211>  20
<212>  PRT
<213>  Artifical

<400>  22
Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe Asp 
1               5                   10                  15      
Val Leu Asp Lys 
            20  

<210>  23
<211>  60
<212>  DNA
<213>  Artifical

<400>  23
aaccagctct ttaacgagct caatctagga cgaagagagg agttcgatgt tttggacaag        60

<210>  24
<211>  21
<212>  PRT
<213>  Artifical

<400>  24
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
1               5                   10                  15      
Ser Glu Ile Gly Met 
            20      

<210>  25
<211>  63
<212>  DNA
<213>  Artifical

<400>  25
gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg        60
atg                                                                      63

<210>  26
<211>  21
<212>  PRT
<213>  Artifical

<400>  26
Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe 
1               5                   10                  15      
Ser Glu Ile Gly Met 
            20      

<210>  27
<211>  63
<212>  DNA
<213>  Artifical

<400>  27
gaaggcctgt tcaatgaact gcagaaagat aagatggcgg aggccttcag tgagattggg        60
atg                                                                      63

<210>  28
<211>  20
<212>  PRT
<213>  Artifical

<400>  28
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      
Ala Leu His Met 
            20  

<210>  29
<211>  60
<212>  DNA
<213>  Artifical

<400>  29
gatggccttt accagggact cagtacagcc accaaggaca cctacgacgc ccttcacatg        60

<210>  30
<211>  20
<212>  PRT
<213>  Artifical

<400>  30
Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp 
1               5                   10                  15      
Ala Leu His Met 
            20  

<210>  31
<211>  60
<212>  DNA
<213>  Artifical

<400>  31
gatggccttt tccagggact cagtacagcc accaaggaca ccttcgacgc ccttcacatg        60

<210>  32
<211>  20
<212>  PRT
<213>  Artifical

<400>  32
Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly 
1               5                   10                  15      
Leu Asn Gln Arg 
            20  

<210>  33
<211>  60
<212>  DNA
<213>  Artifical

<400>  33
ccagactatg agcccatccg gaaaggccag cgggacctgt attctggcct gaatcagaga        60

<210>  34
<211>  20
<212>  PRT
<213>  Artifical

<400>  34
Pro Asp Phe Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Phe Ser Gly 
1               5                   10                  15      
Leu Asn Gln Arg 
            20  

<210>  35
<211>  60
<212>  DNA
<213>  Artifical

<400>  35
ccagactttg agcccatccg gaaaggccag cgggacctgt tttctggcct gaatcagaga        60

<210>  36
<211>  27
<212>  PRT
<213>  Artifical

<400>  36
Gly Gly Tyr Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys 
1               5                   10                  15      
Asn Ile Tyr Leu Thr Leu Pro Pro Asn Gly Thr 
            20                  25          

<210>  37
<211>  81
<212>  DNA
<213>  Artifical

<400>  37
ggcggctaca tgactctgaa ccccagggca cctactgacg atgataaaaa catctacctg        60
actcttcctc ccaacggtac c                                                  81

<210>  38
<211>  20
<212>  PRT
<213>  Artifical

<400>  38
Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr 
1               5                   10                  15      
Leu Lys His Glu 
            20  

<210>  39
<211>  60
<212>  DNA
<213>  Artifical

<400>  39
ggtgtttaca cgggcctgag caccaggaac caggagactt acgagactct gaagcatgag        60

<210>  40
<211>  22
<212>  PRT
<213>  Artifical

<400>  40
Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
1               5                   10                  15      
Leu Asn Thr Gln Gly Thr 
            20          

<210>  41
<211>  66
<212>  DNA
<213>  Artifical

<400>  41
tcgccttatc aggaactcca gggtcagagg tcggatgtct acagcgacct caacacacag        60
ggtacc                                                                   66

<210>  42
<211>  618
<212>  PRT
<213>  Artifical

<400>  42
Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser Arg 
1               5                   10                  15      
Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly Leu 
            20                  25                  30          
Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu Ser 
        35                  40                  45              
Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln Leu 
    50                  55                  60                  
Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro Ala 
65                  70                  75                  80  
Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys Asn 
                85                  90                  95      
Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro Gly 
            100                 105                 110         
Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg Gln 
        115                 120                 125             
Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser Gln 
    130                 135                 140                 
Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg Met 
145                 150                 155                 160 
Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys Leu 
                165                 170                 175     
Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg Lys 
            180                 185                 190         
Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val Tyr 
        195                 200                 205             
His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro Glu 
    210                 215                 220                 
Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys Leu 
225                 230                 235                 240 
Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn Ser 
                245                 250                 255     
Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala His 
            260                 265                 270         
Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn Ser 
        275                 280                 285             
Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys Pro 
    290                 295                 300                 
Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp 
305                 310                 315                 320 
Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu 
                325                 330                 335     
Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg 
            340                 345                 350         
Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys 
        355                 360                 365             
Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg 
    370                 375                 380                 
Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu 
385                 390                 395                 400 
Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala 
                405                 410                 415     
Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile 
            420                 425                 430         
Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met 
        435                 440                 445             
Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg 
    450                 455                 460                 
Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly 
465                 470                 475                 480 
Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser 
                485                 490                 495     
Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe 
            500                 505                 510         
Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met 
        515                 520                 525             
Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly 
    530                 535                 540                 
Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro 
545                 550                 555                 560 
Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile 
                565                 570                 575     
Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met 
            580                 585                 590         
Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro Gly 
        595                 600                 605             
Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615             

<210>  43
<211>  1854
<212>  DNA
<213>  Artifical

<400>  43
ccagaccccg cggcgcacct gcccttcttc tacggcagca tctcgcgtgc cgaggccgag        60
gagcacctga agctggcggg catggcggac gggctcttcc tgctgcgcca gtgcctgcgc       120
tcgctgggcg gctatgtgct gtcgctcgtg cacgatgtgc gcttccacca ctttcccatc       180
gagcgccagc tcaacggcac ctacgccatt gccggcggca aagcgcactg tggaccggca       240
gagctctgcg agttctactc gcgcgacccc gacgggctgc cctgcaacct gcgcaagccg       300
tgcaaccggc cgtcgggcct cgagccgcag ccgggggtct tcgactgcct gcgagacgcc       360
atggtgcgtg actacgtgcg ccagacgtgg aagctggagg gcgaggccct ggagcaggcc       420
atcatcagcc aggccccgca ggtggagaag ctcattgcta cgacggccca cgagcggatg       480
ccctggtacc acagcagcct gacgcgtgag gaggccgagc gcaaacttta ctctggggcg       540
cagaccgacg gcaagttcct gctgaggccg cggaaggagc agggcacata cgccctgtcc       600
ctcatctatg ggaagacggt gtaccactac ctcatcagcc aagacaaggc gggcaagtac       660
tgcattcccg agggcaccaa gtttgacacg ctctggcagc tggtggagta tctgaagctg       720
aaggcggacg ggctcatcta ctgcctgaag gaggcctgcc ccaacagcag tgccagcaac       780
gcctcagggg ctgctgctcc cacactccca gcccacccat ccacgttgac tcatcctcag       840
agacgaatcg acaccctcaa ctcagatgga tacacccctg agccagcacg cataacgtcc       900
ccagacaaac cgcggccgat gcccatggac acgagcgtgt atgagagccc ctacagcgac       960
ccagaggagc tcaaggacaa gaagctcttc ctgaagcgcg ataacctcct catagctgac      1020
attgaacttg gctgcggcaa ctttggctca gtgcgccagg gcgtgtaccg catgcgcaag      1080
aagcagatcg acgtggccat caaggtgctg aagcagggca cggagaaggc agacacggaa      1140
gagatgatgc gcgaggcgca gatcatgcac cagctggaca acccctacat cgtgcggctc      1200
attggcgtct gccaggccga ggccctcatg ctggtcatgg agatggctgg gggcgggccg      1260
ctgcacaagt tcctggtcgg caagagggag gagatccctg tgagcaatgt ggccgagctg      1320
ctgcaccagg tgtccatggg gatgaagtac ctggaggaga agaactttgt gcaccgtgac      1380
ctggcggccc gcaacgtcct gctggttaac cggcactacg ccaagatcag cgactttggc      1440
ctctccaaag cactgggtgc cgacgacagc tactacactg cccgctcagc agggaagtgg      1500
ccgctcaagt ggtacgcacc cgaatgcatc aacttccgca agttctccag ccgcagcgat      1560
gtctggagct atggggtcac catgtgggag gccttgtcct acggccagaa gccctacaag      1620
aagatgaaag ggccggaggt catggccttc atcgagcagg gcaagcggat ggagtgccca      1680
ccagagtgtc cacccgaact gtacgcactc atgagtgact gctggatcta caagtgggag      1740
gatcgccccg acttcctgac cgtggagcag cgcatgcgag cctgttacta cagcctggcc      1800
agcaaggtgg aagggccccc aggcagcaca cagaaggctg aggctgcctg tgcc            1854

<210>  44
<211>  634
<212>  PRT
<213>  Artifical

<400>  44
Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe Phe 
1               5                   10                  15      
Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly Gly 
            20                  25                  30          
Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu Gly 
        35                  40                  45              
Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr Thr 
    50                  55                  60                  
Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg Thr 
65                  70                  75                  80  
His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser Asp 
                85                  90                  95      
Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly Val 
            100                 105                 110         
Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile Arg 
        115                 120                 125             
Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu Gln 
    130                 135                 140                 
Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr Thr 
145                 150                 155                 160 
Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu Glu 
                165                 170                 175     
Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe Leu 
            180                 185                 190         
Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu His 
        195                 200                 205             
Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly Lys 
    210                 215                 220                 
Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu Val 
225                 230                 235                 240 
Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr Val 
                245                 250                 255     
Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly Arg 
            260                 265                 270         
Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly Ile 
        275                 280                 285             
Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys Pro Gly His Arg Lys 
    290                 295                 300                 
Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser Thr Val Ser Phe Asn 
305                 310                 315                 320 
Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro Gln 
                325                 330                 335     
Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr Ala 
            340                 345                 350         
Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys Leu 
        355                 360                 365             
Leu Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr Val 
    370                 375                 380                 
Lys Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala Val 
385                 390                 395                 400 
Lys Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu Leu 
                405                 410                 415     
Leu Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile Val 
            420                 425                 430         
Arg Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met Glu 
        435                 440                 445             
Met Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg His 
    450                 455                 460                 
Val Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met Gly 
465                 470                 475                 480 
Met Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala Ala 
                485                 490                 495     
Arg Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp Phe 
            500                 505                 510         
Gly Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala Gln 
        515                 520                 525             
Thr His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
    530                 535                 540                 
Tyr Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu 
545                 550                 555                 560 
Met Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met Lys 
                565                 570                 575     
Gly Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly Cys 
            580                 585                 590         
Pro Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys Trp 
        595                 600                 605             
Thr Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu Arg 
    610                 615                 620                 
Leu Arg Asn Tyr Tyr Tyr Asp Val Val Asn 
625                 630                 

<210>  45
<211>  1902
<212>  DNA
<213>  Artifical

<400>  45
gccagcagcg gcatggctga cagcgccaac cacctgccct tctttttcgg caacatcacc        60
cgggaggagg cagaagatta cctggtccag gggggcatga gtgatgggct ttatttgctg       120
cgccagagcc gcaactacct gggtggcttc gccctgtccg tggcccacgg gaggaaggca       180
caccactaca ccatcgagcg ggagctgaat ggcacctacg ccatcgccgg tggcaggacc       240
catgccagcc ccgccgacct ctgccactac cactcccagg agtctgatgg cctggtctgc       300
ctcctcaaga agcccttcaa ccggccccaa ggggtgcagc ccaagactgg gccctttgag       360
gatttgaagg aaaacctcat cagggaatat gtgaagcaga catggaacct gcagggtcag       420
gctctggagc aggccatcat cagtcagaag cctcagctgg agaagctgat cgctaccaca       480
gcccatgaaa aaatgccttg gttccatgga aaaatctctc gggaagaatc tgagcaaatt       540
gtcctgatag gatcaaagac aaatggaaag ttcctgatcc gagccagaga caacaacggc       600
tcctacgccc tgtgcctgct gcacgaaggg aaggtgctgc actatcgcat cgacaaagac       660
aagacaggga agctctccat ccccgaggga aagaagttcg acacgctctg gcagctagtc       720
gagcattatt cttataaagc agatggtttg ttaagagttc ttactgtccc atgtcaaaaa       780
atcggcacac agggaaatgt taattttgga ggccgtccac aacttccagg ttcccatcct       840
gcgacttggt cagcgggtgg aataatctca agaatcaaat catactcctt cccaaagcct       900
ggccacagaa agtcctcccc tgcccaaggg aaccggcaag agagtactgt gtcattcaat       960
ccgtatgagc cagaacttgc accctgggct gcagacaaag gcccccagag agaagcccta      1020
cccatggaca cagaggtgta cgagagcccc tacgcggacc ccgaggagat caggcccaag      1080
gaggtttacc tggaccgaaa gctgctgacg ctggaagaca aagaactggg ctctggtaat      1140
tttggaactg tgaaaaaggg ctactaccaa atgaaaaaag ttgtgaaaac cgtggctgtg      1200
aaaatactga aaaacgaggc caatgacccc gctcttaaag atgagttatt agcagaagca      1260
aatgtcatgc agcagctgga caacccgtac atcgtgcgga tgatcgggat atgcgaggcc      1320
gagtcctgga tgctggttat ggagatggca gaacttggtc ccctcaataa gtatttgcag      1380
cagaacagac atgtcaagga taagaacatc atagaactgg ttcatcaggt ttccatgggc      1440
atgaagtact tggaggagag caattttgtg cacagagatc tggctgcaag aaatgtgttg      1500
ctagttaccc aacattacgc caagatcagt gatttcggac tttccaaagc actgcgtgct      1560
gatgaaaact actacaaggc ccagacccat ggaaagtggc ctgtcaagtg gtacgctccg      1620
gaatgcatca actactacaa gttctccagc aaaagcgatg tctggagctt tggagtgttg      1680
atgtgggaag cattctccta tgggcagaag ccatatcgag ggatgaaagg aagtgaagtc      1740
accgctatgt tagagaaagg agagcggatg gggtgccctg cagggtgtcc aagagagatg      1800
tacgatctca tgaatctgtg ctggacatac gatgtggaaa acaggcccgg attcgcagca      1860
gtggaactgc ggctgcgcaa ttactactat gacgtggtga ac                         1902

<210>  46
<211>  336
<212>  PRT
<213>  Artifical

<400>  46
Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser Arg 
1               5                   10                  15      
Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly Leu 
            20                  25                  30          
Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu Ser 
        35                  40                  45              
Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln Leu 
    50                  55                  60                  
Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro Ala 
65                  70                  75                  80  
Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys Asn 
                85                  90                  95      
Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro Gly 
            100                 105                 110         
Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg Gln 
        115                 120                 125             
Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser Gln 
    130                 135                 140                 
Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg Met 
145                 150                 155                 160 
Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys Leu 
                165                 170                 175     
Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg Lys 
            180                 185                 190         
Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val Tyr 
        195                 200                 205             
His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro Glu 
    210                 215                 220                 
Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys Leu 
225                 230                 235                 240 
Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn Ser 
                245                 250                 255     
Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala His 
            260                 265                 270         
Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn Ser 
        275                 280                 285             
Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys Pro 
    290                 295                 300                 
Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp 
305                 310                 315                 320 
Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu 
                325                 330                 335     

<210>  47
<211>  1008
<212>  DNA
<213>  Artifical

<400>  47
ccagaccccg cggcgcacct gcccttcttc tacggcagca tctcgcgtgc cgaggccgag        60
gagcacctga agctggcggg catggcggac gggctcttcc tgctgcgcca gtgcctgcgc       120
tcgctgggcg gctatgtgct gtcgctcgtg cacgatgtgc gcttccacca ctttcccatc       180
gagcgccagc tcaacggcac ctacgccatt gccggcggca aagcgcactg tggaccggca       240
gagctctgcg agttctactc gcgcgacccc gacgggctgc cctgcaacct gcgcaagccg       300
tgcaaccggc cgtcgggcct cgagccgcag ccgggggtct tcgactgcct gcgagacgcc       360
atggtgcgtg actacgtgcg ccagacgtgg aagctggagg gcgaggccct ggagcaggcc       420
atcatcagcc aggccccgca ggtggagaag ctcattgcta cgacggccca cgagcggatg       480
ccctggtacc acagcagcct gacgcgtgag gaggccgagc gcaaacttta ctctggggcg       540
cagaccgacg gcaagttcct gctgaggccg cggaaggagc agggcacata cgccctgtcc       600
ctcatctatg ggaagacggt gtaccactac ctcatcagcc aagacaaggc gggcaagtac       660
tgcattcccg agggcaccaa gtttgacacg ctctggcagc tggtggagta tctgaagctg       720
aaggcggacg ggctcatcta ctgcctgaag gaggcctgcc ccaacagcag tgccagcaac       780
gcctcagggg ctgctgctcc cacactccca gcccacccat ccacgttgac tcatcctcag       840
agacgaatcg acaccctcaa ctcagatgga tacacccctg agccagcacg cataacgtcc       900
ccagacaaac cgcggccgat gcccatggac acgagcgtgt atgagagccc ctacagcgac       960
ccagaggagc tcaaggacaa gaagctcttc ctgaagcgcg ataacctc                   1008

<210>  48
<211>  369
<212>  PRT
<213>  Artifical

<400>  48
Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe Phe 
1               5                   10                  15      
Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly Gly 
            20                  25                  30          
Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu Gly 
        35                  40                  45              
Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr Thr 
    50                  55                  60                  
Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg Thr 
65                  70                  75                  80  
His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser Asp 
                85                  90                  95      
Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly Val 
            100                 105                 110         
Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile Arg 
        115                 120                 125             
Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu Gln 
    130                 135                 140                 
Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr Thr 
145                 150                 155                 160 
Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu Glu 
                165                 170                 175     
Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe Leu 
            180                 185                 190         
Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu His 
        195                 200                 205             
Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly Lys 
    210                 215                 220                 
Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu Val 
225                 230                 235                 240 
Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr Val 
                245                 250                 255     
Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly Arg 
            260                 265                 270         
Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly Ile 
        275                 280                 285             
Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys Pro Gly His Arg Lys 
    290                 295                 300                 
Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser Thr Val Ser Phe Asn 
305                 310                 315                 320 
Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro Gln 
                325                 330                 335     
Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr Ala 
            340                 345                 350         
Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys Leu 
        355                 360                 365             
Leu 
    

<210>  49
<211>  1107
<212>  DNA
<213>  Artifical

<400>  49
gccagcagcg gcatggctga cagcgccaac cacctgccct tctttttcgg caacatcacc        60
cgggaggagg cagaagatta cctggtccag gggggcatga gtgatgggct ttatttgctg       120
cgccagagcc gcaactacct gggtggcttc gccctgtccg tggcccacgg gaggaaggca       180
caccactaca ccatcgagcg ggagctgaat ggcacctacg ccatcgccgg tggcaggacc       240
catgccagcc ccgccgacct ctgccactac cactcccagg agtctgatgg cctggtctgc       300
ctcctcaaga agcccttcaa ccggccccaa ggggtgcagc ccaagactgg gccctttgag       360
gatttgaagg aaaacctcat cagggaatat gtgaagcaga catggaacct gcagggtcag       420
gctctggagc aggccatcat cagtcagaag cctcagctgg agaagctgat cgctaccaca       480
gcccatgaaa aaatgccttg gttccatgga aaaatctctc gggaagaatc tgagcaaatt       540
gtcctgatag gatcaaagac aaatggaaag ttcctgatcc gagccagaga caacaacggc       600
tcctacgccc tgtgcctgct gcacgaaggg aaggtgctgc actatcgcat cgacaaagac       660
aagacaggga agctctccat ccccgaggga aagaagttcg acacgctctg gcagctagtc       720
gagcattatt cttataaagc agatggtttg ttaagagttc ttactgtccc atgtcaaaaa       780
atcggcacac agggaaatgt taattttgga ggccgtccac aacttccagg ttcccatcct       840
gcgacttggt cagcgggtgg aataatctca agaatcaaat catactcctt cccaaagcct       900
ggccacagaa agtcctcccc tgcccaaggg aaccggcaag agagtactgt gtcattcaat       960
ccgtatgagc cagaacttgc accctgggct gcagacaaag gcccccagag agaagcccta      1020
cccatggaca cagaggtgta cgagagcccc tacgcggacc ccgaggagat caggcccaag      1080
gaggtttacc tggaccgaaa gctgctg                                          1107

<210>  50
<211>  263
<212>  PRT
<213>  Artifical

<400>  50
Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg 
1               5                   10                  15      
Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys 
            20                  25                  30          
Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg 
        35                  40                  45              
Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu 
    50                  55                  60                  
Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala 
65                  70                  75                  80  
Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile 
                85                  90                  95      
Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met 
            100                 105                 110         
Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg 
        115                 120                 125             
Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly 
    130                 135                 140                 
Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser 
145                 150                 155                 160 
Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe 
                165                 170                 175     
Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met 
            180                 185                 190         
Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly 
        195                 200                 205             
Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro 
    210                 215                 220                 
Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile 
225                 230                 235                 240 
Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met 
                245                 250                 255     
Arg Ala Cys Tyr Tyr Ser Leu 
            260             

<210>  51
<211>  789
<212>  DNA
<213>  Artifical

<400>  51
ctcatagctg acattgaact tggctgcggc aactttggct cagtgcgcca gggcgtgtac        60
cgcatgcgca agaagcagat cgacgtggcc atcaaggtgc tgaagcaggg cacggagaag       120
gcagacacgg aagagatgat gcgcgaggcg cagatcatgc accagctgga caacccctac       180
atcgtgcggc tcattggcgt ctgccaggcc gaggccctca tgctggtcat ggagatggct       240
gggggcgggc cgctgcacaa gttcctggtc ggcaagaggg aggagatccc tgtgagcaat       300
gtggccgagc tgctgcacca ggtgtccatg gggatgaagt acctggagga gaagaacttt       360
gtgcaccgtg acctggcggc ccgcaacgtc ctgctggtta accggcacta cgccaagatc       420
agcgactttg gcctctccaa agcactgggt gccgacgaca gctactacac tgcccgctca       480
gcagggaagt ggccgctcaa gtggtacgca cccgaatgca tcaacttccg caagttctcc       540
agccgcagcg atgtctggag ctatggggtc accatgtggg aggccttgtc ctacggccag       600
aagccctaca agaagatgaa agggccggag gtcatggcct tcatcgagca gggcaagcgg       660
atggagtgcc caccagagtg tccacccgaa ctgtacgcac tcatgagtga ctgctggatc       720
tacaagtggg aggatcgccc cgacttcctg accgtggagc agcgcatgcg agcctgttac       780
tacagcctg                                                               789

<210>  52
<211>  261
<212>  PRT
<213>  Artifical

<400>  52
Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr Val Lys 
1               5                   10                  15      
Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala Val Lys 
            20                  25                  30          
Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu Leu Leu 
        35                  40                  45              
Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile Val Arg 
    50                  55                  60                  
Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met Glu Met 
65                  70                  75                  80  
Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg His Val 
                85                  90                  95      
Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met Gly Met 
            100                 105                 110         
Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala Ala Arg 
        115                 120                 125             
Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp Phe Gly 
    130                 135                 140                 
Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala Gln Thr 
145                 150                 155                 160 
His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile Asn Tyr 
                165                 170                 175     
Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu Met 
            180                 185                 190         
Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met Lys Gly 
        195                 200                 205             
Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly Cys Pro 
    210                 215                 220                 
Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys Trp Thr 
225                 230                 235                 240 
Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu Arg Leu 
                245                 250                 255     
Arg Asn Tyr Tyr Tyr 
            260     

<210>  53
<211>  783
<212>  DNA
<213>  Artifical

<400>  53
acgctggaag acaaagaact gggctctggt aattttggaa ctgtgaaaaa gggctactac        60
caaatgaaaa aagttgtgaa aaccgtggct gtgaaaatac tgaaaaacga ggccaatgac       120
cccgctctta aagatgagtt attagcagaa gcaaatgtca tgcagcagct ggacaacccg       180
tacatcgtgc ggatgatcgg gatatgcgag gccgagtcct ggatgctggt tatggagatg       240
gcagaacttg gtcccctcaa taagtatttg cagcagaaca gacatgtcaa ggataagaac       300
atcatagaac tggttcatca ggtttccatg ggcatgaagt acttggagga gagcaatttt       360
gtgcacagag atctggctgc aagaaatgtg ttgctagtta cccaacatta cgccaagatc       420
agtgatttcg gactttccaa agcactgcgt gctgatgaaa actactacaa ggcccagacc       480
catggaaagt ggcctgtcaa gtggtacgct ccggaatgca tcaactacta caagttctcc       540
agcaaaagcg atgtctggag ctttggagtg ttgatgtggg aagcattctc ctatgggcag       600
aagccatatc gagggatgaa aggaagtgaa gtcaccgcta tgttagagaa aggagagcgg       660
atggggtgcc ctgcagggtg tccaagagag atgtacgatc tcatgaatct gtgctggaca       720
tacgatgtgg aaaacaggcc cggattcgca gcagtggaac tgcggctgcg caattactac       780
tat                                                                     783

<210>  54
<211>  29
<212>  PRT
<213>  Artifical

<400>  54
Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
1               5                   10                  15      
Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser 
            20                  25                  

<210>  55
<211>  87
<212>  DNA
<213>  Artifical

<400>  55
tgctcccggg ccgcacgagg gacaatagga gccaggcgca ccggccagcc cctgaaggag        60
gacccctcag ccgtgcctgt gttctct                                            87

<210>  56
<211>  97
<212>  PRT
<213>  Artifical

<400>  56
Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
1               5                   10                  15      
Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr 
            20                  25                  30          
Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val 
        35                  40                  45              
Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser 
    50                  55                  60                  
Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro 
65                  70                  75                  80  
Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro 
                85                  90                  95      
Leu 
    

<210>  57
<211>  291
<212>  DNA
<213>  Artifical

<400>  57
tgctcccggg ccgcacgagg gacaatagga gccaggcgca ccggccagcc cctgaaggag        60
gacccctcag ccgtgcctgt gttctctgtg gactatgggg agctggattt ccagtggcga       120
gagaagaccc cggagccccc cgtgccctgt gtccctgagc agacggagta tgccaccatt       180
gtctttccta gcggaatggg cacctcatcc cccgcccgca ggggctcagc tgacggccct       240
cggagtgccc agccactgag gcctgaggat ggacactgct cttggcccct c                291

<210>  58
<211>  12
<212>  PRT
<213>  Artifical

<400>  58
Gly Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Thr 
1               5                   10          

<210>  59
<211>  36
<212>  DNA
<213>  Artifical

<400>  59
ggcgggtctg gcgggacagg aggttcaggt ggcaca                                  36

<210>  60
<211>  34
<212>  PRT
<213>  Artifical

<400>  60
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
            20                  25                  30          
Thr Lys 
        

<210>  61
<211>  102
<212>  DNA
<213>  Artifical

<400>  61
ggttcaactt ctggctctgg gaaaccagga agcggcgaag ggtccaccaa gggaagcacc        60
agtggttcag gtaagcctgg ttctggtgaa ggtagcacta aa                          102

<210>  62
<211>  128
<212>  PRT
<213>  Artifical

<400>  62
Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
1               5                   10                  15      
Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
            20                  25                  30          
Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
        35                  40                  45              
Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
    50                  55                  60                  
Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
65                  70                  75                  80  
Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
                85                  90                  95      
Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
            100                 105                 110         
Ser Ala Gly Gly Gly Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Thr 
        115                 120                 125             

<210>  63
<211>  384
<212>  DNA
<213>  Artifical

<400>  63
agcgcaggcg gatcagctgg agggtctgca gggggtagtg caggtggctc agctggcggg        60
agcggctcag ctgggggatc tgctggtggc agtacctcag caggcggtag cgccggaggt       120
tctgctggtg gctccgcagg agggtctgca ggcggttccg ggagtgcagg tggatctgca       180
ggtgggtcaa caagtgctgg tggatccgca ggaggttcag caggcgggag tgctggaggc       240
tctgcaggcg gtagcgggag tgccggtggc agcgcagggg gaagcactag tgctggaggc       300
agtgcaggtg gcagcgcagg aggctctgcc gggggaagcg ccgggggcgg cgggtctggc       360
gggacaggag gttcaggtgg caca                                              384

<210>  64
<211>  116
<212>  PRT
<213>  Artifical

<400>  64
Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
1               5                   10                  15      
Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
            20                  25                  30          
Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
        35                  40                  45              
Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
    50                  55                  60                  
Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
65                  70                  75                  80  
Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
                85                  90                  95      
Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
            100                 105                 110         
Ser Ala Gly Gly 
        115     

<210>  65
<211>  348
<212>  DNA
<213>  Artifical

<400>  65
agcgcaggcg gatcagctgg agggtctgca gggggtagtg caggtggctc agctggcggg        60
agcggctcag ctgggggatc tgctggtggc agtacctcag caggcggtag cgccggaggt       120
tctgctggtg gctccgcagg agggtctgca ggcggttccg ggagtgcagg tggatctgca       180
ggtgggtcaa caagtgctgg tggatccgca ggaggttcag caggcgggag tgctggaggc       240
tctgcaggcg gtagcgggag tgccggtggc agcgcagggg gaagcactag tgctggaggc       300
agtgcaggtg gcagcgcagg aggctctgcc gggggaagcg ccgggggc                    348

<210>  66
<211>  6
<212>  PRT
<213>  Artifical

<400>  66
Gly Gly Ser Gly Gly Thr 
1               5       

<210>  67
<211>  23
<212>  DNA
<213>  artificial

<400>  67
cgacagtacc attgagttgt gcg                                                23

<210>  68
<211>  23
<212>  DNA
<213>  artificial

<400>  68
ttcgtccata ggagacaatg ccc                                                23

<210>  69
<211>  22
<212>  DNA
<213>  artificial

<400>  69
actcacaggc agccaacttt gc                                                 22

<210>  70
<211>  22
<212>  DNA
<213>  artificial

<400>  70
ctcttgaagt cagggtgcag cg                                                 22

<210>  71
<211>  22
<212>  DNA
<213>  artificial

<400>  71
ctcttctgcc tgctgcactt tg                                                 22

<210>  72
<211>  22
<212>  DNA
<213>  artificial

<400>  72
atgggctaca ggcttgtcac tc                                                 22

<210>  73
<211>  23
<212>  DNA
<213>  artificial

<400>  73
gagtgtggag accatcaagg aag                                                23

<210>  74
<211>  24
<212>  DNA
<213>  artificial

<400>  74
tgctttgcgt tggacattca agtc                                               24

<210>  75
<211>  22
<212>  DNA
<213>  artificial

<400>  75
catcacctgg aggacttcta cc                                                 22

<210>  76
<211>  23
<212>  DNA
<213>  artificial

<400>  76
cagtgtactg gatgctcttc agg                                                23

<210>  77
<211>  22
<212>  DNA
<213>  artificial

<400>  77
ggtatgagag ccaggcttct tg                                                 22

<210>  78
<211>  22
<212>  DNA
<213>  artificial

<400>  78
gaatggagcc atcttcccac tg                                                 22

<210>  79
<211>  22
<212>  DNA
<213>  artificial

<400>  79
cagcaacttg ctggatctgg tg                                                 22

<210>  80
<211>  22
<212>  DNA
<213>  artificial

<400>  80
agacggcagt agaaggtcac ct                                                 22

