                         SEQUENCE LISTING

<110>  SYNGENTA BIOTECHNOLOGY CHINA CO, LTD
       SYNGENTA CROP PROTECTION AG
 
<120>  CONTROL OF NOCTUID, CRAMBID, AND PYRALID PESTS

<130>  82216-WO-REG-ORG-P--1

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A BT-0001 protein

<400>  1

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Ser Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Met Ala Gln Arg Ile Glu 
        275                 280                 285             


Gln Asn Ile Arg Gln Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Val His Arg Gly Phe Asn Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Thr Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Ala Phe Pro 
                325                 330                 335     


Leu Phe Gly Asn Ala Gly Asn Ala Ala Pro Pro Val Leu Val Ser Leu 
            340                 345                 350         


Thr Gly Leu Gly Ile Phe Arg Thr Leu Ser Ser Pro Leu Tyr Arg Arg 
        355                 360                 365             


Ile Ile Leu Gly Ser Gly Pro Asn Asn Gln Glu Leu Phe Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ser Phe Ala Ser Leu Thr Thr Asn Leu Pro Ser Thr 
385                 390                 395                 400 


Ile Tyr Arg Gln Arg Gly Thr Val Asp Ser Leu Asp Val Ile Pro Pro 
                405                 410                 415     


Gln Asp Asn Ser Val Pro Pro Arg Ala Gly Phe Ser His Arg Leu Ser 
            420                 425                 430         


His Val Thr Met Leu Ser Gln Ala Ala Gly Ala Val Tyr Thr Leu Arg 
        435                 440                 445             


Ala Pro Thr Phe Ser Trp Gln His Arg Ser Ala Glu Phe Asn Asn Ile 
    450                 455                 460                 


Ile Ala Ser Asp Ser Ile Thr Gln Ile Pro Ala Val Lys Gly Asn Phe 
465                 470                 475                 480 


Leu Phe Asn Gly Ser Val Ile Ser Gly Pro Gly Phe Thr Gly Gly Asp 
                485                 490                 495     


Leu Val Arg Leu Asn Ser Ser Gly Asn Asn Ile Gln Asn Arg Gly Tyr 
            500                 505                 510         


Ile Glu Val Pro Ile His Phe Pro Ser Thr Ser Thr Arg Tyr Arg Val 
        515                 520                 525             


Arg Val Arg Tyr Ala Ser Val Thr Pro Ile His Leu Asn Val Asn Trp 
    530                 535                 540                 


Gly Asn Ser Ser Ile Phe Ser Asn Thr Val Pro Ala Thr Ala Thr Ser 
545                 550                 555                 560 


Leu Asp Asn Leu Gln Ser Ser Asp Phe Gly Tyr Phe Glu Ser Ala Asn 
                565                 570                 575     


Ala Phe Thr Ser Ser Leu Gly Asn Ile Val Gly Val Arg Asn Phe Ser 
            580                 585                 590         


Gly Thr Ala Gly Val Ile Ile Asp Arg Phe Glu Phe Ile Pro Val Thr 
        595                 600                 605             


Ala Thr Leu Glu Ala Glu Tyr Asn Leu Glu Arg Ala Gln Lys Ala Val 
    610                 615                 620                 


Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn Val 
625                 630                 635                 640 


Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Thr Cys Leu Ser 
                645                 650                 655     


Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val Lys 
            660                 665                 670         


His Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser Asn 
        675                 680                 685             


Phe Lys Asp Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser Thr 
    690                 695                 700                 


Gly Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val 
705                 710                 715                 720 


Thr Leu Ser Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln 
                725                 730                 735     


Lys Ile Asp Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu Arg 
            740                 745                 750         


Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr Leu Ile Arg Tyr 
        755                 760                 765             


Asn Ala Lys His Glu Thr Leu Asn Val Pro Gly Thr Gly Ser Leu Trp 
    770                 775                 780                 


Pro Leu Ala Val Lys Ser Pro Ile Gly Arg Cys Gly Glu Pro Asn Arg 
785                 790                 795                 800 


Cys Ala Pro Arg Ile Glu Trp Lys Pro Asp Val Asp Cys Ser Cys Arg 
                805                 810                 815     


Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp Ile 
            820                 825                 830         


Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile 
        835                 840                 845             


Phe Lys Ile Lys Thr Gln Asp Gly His Ala Lys Ile Gly Asn Leu Glu 
    850                 855                 860                 


Phe Leu Glu Glu Lys Leu Leu Leu Gly Glu Ala Leu Ala Arg Val Lys 
865                 870                 875                 880 


Lys Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu 
                885                 890                 895     


Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe 
            900                 905                 910         


Val Asp Ser Gln Tyr Asn Arg Leu Gln Thr Asp Thr Asn Ile Ala Met 
        915                 920                 925             


Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg Glu Ala Tyr Leu 
    930                 935                 940                 


Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu 
945                 950                 955                 960 


Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg Asn 
                965                 970                 975     


Val Ile Lys Asn Gly Asp Phe Asn Tyr Gly Leu Ser Cys Trp Asn Val 
            980                 985                 990         


Lys Gly His Val Asp Val Glu Glu  Gln Asn Asn His Arg  Ser Val Leu 
        995                 1000                 1005             


Val Ile  Pro Glu Trp Glu Ala  Glu Val Ser Gln Glu  Val Arg Val 
    1010                 1015                 1020             


Cys Pro  Gly Arg Gly Tyr Ile  Leu Arg Val Thr Ala  Tyr Lys Glu 
    1025                 1030                 1035             


Gly Tyr  Gly Glu Gly Cys Val  Thr Ile His Glu Ile  Glu Asp Asn 
    1040                 1045                 1050             


Thr Asp  Glu Leu Lys Phe Ser  Asn Cys Val Glu Glu  Glu Val Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Thr Val Thr Cys  Asn Asp Tyr Thr Ala  Thr Gln Glu 
    1070                 1075                 1080             


Glu Tyr  Glu Gly Thr Tyr Thr  Ser Arg Asn Arg Gly  Tyr Asp Gly 
    1085                 1090                 1095             


Ala Tyr  Glu Ser Asn Ser Ser  Val Pro Ala Asp Tyr  Ala Ser Ala 
    1100                 1105                 1110             


Tyr Glu  Glu Lys Ala Tyr Thr  Asp Gly Arg Arg Asp  Asn Pro Cys 
    1115                 1120                 1125             


Glu Ser  Asn Arg Gly Tyr Arg  Asp Tyr Thr Pro Leu  Pro Ala Gly 
    1130                 1135                 1140             


Tyr Val  Thr Lys Glu Leu Glu  Tyr Phe Pro Glu Thr  Asp Lys Val 
    1145                 1150                 1155             


Trp Ile  Glu Ile Gly Glu Thr  Glu Gly Thr Phe Ile  Val Asp Ser 
    1160                 1165                 1170             


Val Glu  Leu Leu Leu Met Glu  Glu 
    1175                 1180     


<210>  2
<211>  1181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A BT-0001 mutant sequence

<400>  2

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Ser Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Met Ala Gln Arg Ile Glu 
        275                 280                 285             


Gln Asn Ile Arg Gln Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Val His Arg Gly Phe Asn Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Thr Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Ala Phe Pro 
                325                 330                 335     


Leu Phe Gly Asn Ala Gly Asn Ala Ala Pro Pro Val Leu Val Ser Leu 
            340                 345                 350         


Thr Gly Leu Gly Ile Phe Arg Thr Leu Ser Ser Pro Leu Tyr Arg Arg 
        355                 360                 365             


Ile Ile Leu Gly Ser Gly Pro Asn Asn Gln Glu Leu Phe Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ser Phe Ala Ser Leu Thr Thr Asn Leu Pro Ser Thr 
385                 390                 395                 400 


Ile Tyr Arg Gln Arg Gly Thr Val Asp Ser Leu Asp Val Ile Pro Pro 
                405                 410                 415     


Gln Asp Asn Ser Val Pro Pro Arg Ala Gly Phe Ser His Arg Leu Ser 
            420                 425                 430         


His Val Thr Met Leu Ser Gln Ala Ala Gly Ala Val Tyr Thr Leu Arg 
        435                 440                 445             


Ala Pro Thr Phe Ser Trp Gln His Arg Ser Ala Glu Phe Asn Asn Ile 
    450                 455                 460                 


Ile Ala Ser Asp Ser Ile Thr Gln Ile Pro Ala Val Lys Gly Asn Phe 
465                 470                 475                 480 


Leu Phe Asn Gly Ser Val Ile Ser Gly Pro Gly Phe Thr Gly Gly Asp 
                485                 490                 495     


Leu Val Arg Leu Asn Ser Ser Gly Asn Asn Ile Gln Asn Arg Gly Tyr 
            500                 505                 510         


Ile Glu Val Pro Ile His Phe Pro Ser Thr Ser Thr Arg Tyr Arg Val 
        515                 520                 525             


Arg Val Arg Tyr Ala Ser Val Thr Pro Ile His Leu Asn Val Asn Trp 
    530                 535                 540                 


Gly Asn Ser Ser Ile Phe Ser Asn Thr Val Pro Ala Thr Ala Thr Ser 
545                 550                 555                 560 


Leu Asp Asn Leu Gln Ser Ser Asp Phe Gly Tyr Phe Glu Ser Ala Asn 
                565                 570                 575     


Ala Phe Thr Ser Ser Leu Gly Asn Ile Val Gly Val Arg Asn Phe Ser 
            580                 585                 590         


Gly Thr Ala Gly Val Ile Ile Asp Arg Phe Glu Phe Ile Pro Val Thr 
        595                 600                 605             


Ala Thr Leu Glu Ala Glu Tyr Asn Leu Glu Arg Ala Gln Lys Ala Val 
    610                 615                 620                 


Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn Val 
625                 630                 635                 640 


Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Thr Cys Leu Ser 
                645                 650                 655     


Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val Lys 
            660                 665                 670         


His Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser Asn 
        675                 680                 685             


Phe Lys Asp Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser Thr 
    690                 695                 700                 


Gly Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val 
705                 710                 715                 720 


Thr Leu Ser Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln 
                725                 730                 735     


Lys Ile Asp Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu Arg 
            740                 745                 750         


Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr Leu Ile Arg Tyr 
        755                 760                 765             


Asn Ala Lys His Glu Thr Leu Asn Val Pro Gly Thr Gly Ser Leu Trp 
    770                 775                 780                 


Pro Leu Ala Val Lys Ser Pro Ile Gly Arg Cys Gly Glu Pro Asn Arg 
785                 790                 795                 800 


Cys Ala Pro Arg Ile Glu Trp Lys Pro Asp Val Asp Cys Ser Cys Arg 
                805                 810                 815     


Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp Ile 
            820                 825                 830         


Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile 
        835                 840                 845             


Phe Lys Ile Lys Thr Gln Asp Gly His Ala Lys Ile Gly Asn Leu Glu 
    850                 855                 860                 


Phe Leu Glu Glu Lys Leu Leu Leu Gly Glu Ala Leu Ala Arg Val Lys 
865                 870                 875                 880 


Lys Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu 
                885                 890                 895     


Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe 
            900                 905                 910         


Val Asp Ser Gln Tyr Asn Arg Leu Gln Thr Asp Thr Asn Ile Ala Met 
        915                 920                 925             


Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg Glu Ala Tyr Leu 
    930                 935                 940                 


Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu 
945                 950                 955                 960 


Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg Asn 
                965                 970                 975     


Val Ile Lys Asn Gly Asp Phe Asn Tyr Gly Leu Ser Cys Trp Asn Val 
            980                 985                 990         


Lys Gly His Val Asp Val Glu Glu  Gln Asn Asn His Arg  Ser Val Leu 
        995                 1000                 1005             


Val Ile  Pro Glu Trp Glu Ala  Glu Val Ser Gln Glu  Val Arg Val 
    1010                 1015                 1020             


Cys Pro  Gly Arg Gly Tyr Ile  Leu Arg Val Thr Ala  Tyr Lys Glu 
    1025                 1030                 1035             


Gly Tyr  Gly Glu Gly Cys Val  Thr Ile His Glu Ile  Glu Asp Asn 
    1040                 1045                 1050             


Thr Asp  Glu Leu Lys Phe Ser  Asn Cys Val Glu Glu  Glu Val Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Thr Val Thr Cys  Asn Asp Tyr Thr Ala  Thr Gln Glu 
    1070                 1075                 1080             


Glu Tyr  Glu Gly Thr Tyr Thr  Ser Arg Asn Arg Gly  Tyr Asp Gly 
    1085                 1090                 1095             


Ala Tyr  Glu Ser Asn Ser Ser  Val Pro Ala Asp Tyr  Ala Ser Ala 
    1100                 1105                 1110             


Tyr Glu  Glu Lys Ala Tyr Thr  Asp Gly Arg Arg Asp  Asn Pro Cys 
    1115                 1120                 1125             


Glu Ser  Asn Arg Gly Tyr Arg  Asp Tyr Thr Pro Leu  Pro Ala Gly 
    1130                 1135                 1140             


Tyr Val  Thr Lys Glu Leu Glu  Tyr Phe Pro Glu Thr  Asp Lys Val 
    1145                 1150                 1155             


Trp Ile  Glu Leu Gly Glu Thr  Glu Gly Thr Phe Leu  Val Asp Ser 
    1160                 1165                 1170             


Val Glu  Leu Leu Leu Met Glu  Glu 
    1175                 1180     


<210>  3
<211>  1176
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A BT0003 protein

<400>  3

Met Glu Ile Val Asn Asn Gln Asn Gln Cys Val Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Asn Asn Pro Glu Ile Glu Ile Leu Glu Gly Gly Arg Ile Ser Val Gly 
            20                  25                  30          


Asn Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Ile Asp Leu Ile 
    50                  55                  60                  


Trp Gly Phe Val Gly Pro Ser Gln Trp Asp Ala Phe Leu Ala Gln Val 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Ala Glu Ala Val Arg Asn Thr Ala 
                85                  90                  95      


Ile Gln Glu Leu Glu Gly Met Ala Arg Val Tyr Arg Thr Tyr Ala Thr 
            100                 105                 110         


Ala Phe Ala Glu Trp Glu Lys Ala Pro Asp Asp Pro Glu Leu Arg Glu 
        115                 120                 125             


Ala Leu Arg Thr Gln Phe Thr Ala Thr Glu Thr Tyr Ile Ser Gly Arg 
    130                 135                 140                 


Ile Ser Val Leu Lys Ile Gln Thr Phe Glu Val Gln Leu Leu Ser Val 
145                 150                 155                 160 


Phe Ala Gln Ala Ala Asn Leu His Leu Ser Leu Leu Arg Asp Val Val 
                165                 170                 175     


Phe Phe Gly Gln Arg Trp Gly Phe Ser Thr Thr Thr Val Asn Asn Tyr 
            180                 185                 190         


Tyr Asn Asp Leu Thr Glu Gly Ile Ser Thr Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Ser Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Met Ala Gln Arg Ile Glu 
        275                 280                 285             


Gln Asn Ile Arg Gln Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Val His Arg Gly Phe Asn Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Thr Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Ala Phe Pro 
                325                 330                 335     


Leu Phe Gly Asn Ala Gly Asn Ala Ala Pro Pro Val Leu Val Ser Leu 
            340                 345                 350         


Thr Gly Leu Gly Ile Phe Arg Thr Leu Ser Ser Pro Leu Tyr Arg Arg 
        355                 360                 365             


Ile Ile Leu Gly Ser Gly Pro Asn Asn Gln Glu Leu Phe Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ser Phe Ala Ser Leu Thr Thr Asn Leu Pro Ser Thr 
385                 390                 395                 400 


Ile Tyr Arg Gln Arg Gly Thr Val Asp Ser Leu Asp Val Ile Pro Pro 
                405                 410                 415     


Gln Asp Asn Ser Val Pro Pro Arg Ala Gly Phe Ser His Arg Leu Ser 
            420                 425                 430         


His Val Thr Met Leu Ser Gln Ala Ala Gly Ala Val Tyr Thr Leu Arg 
        435                 440                 445             


Ala Pro Thr Phe Ser Trp Gln His Arg Ser Ala Glu Phe Asn Asn Ile 
    450                 455                 460                 


Ile Pro Ser Ser Gln Ile Thr Gln Ile Pro Leu Thr Lys Ser Thr Asn 
465                 470                 475                 480 


Leu Gly Ser Gly Thr Ser Val Val Lys Gly Pro Gly Phe Thr Gly Gly 
                485                 490                 495     


Asp Ile Leu Arg Arg Thr Ser Pro Gly Gln Ile Ser Thr Leu Arg Val 
            500                 505                 510         


Asn Ile Thr Ala Pro Leu Ser Gln Arg Tyr Arg Val Arg Ile Arg Tyr 
        515                 520                 525             


Ala Ser Thr Thr Asn Leu Gln Phe His Thr Ser Ile Asp Gly Arg Pro 
    530                 535                 540                 


Ile Asn Gln Gly Asn Phe Ser Ala Thr Met Ser Ser Gly Ser Asn Leu 
545                 550                 555                 560 


Gln Ser Gly Ser Phe Arg Thr Val Gly Phe Thr Thr Pro Phe Asn Phe 
                565                 570                 575     


Ser Asn Gly Ser Ser Val Phe Thr Leu Ser Ala His Val Phe Asn Ser 
            580                 585                 590         


Gly Asn Glu Val Tyr Ile Asp Arg Ile Glu Phe Val Pro Ala Glu Val 
        595                 600                 605             


Thr Phe Glu Ala Glu Tyr Asp Leu Glu Arg Ala Gln Lys Ala Val Asn 
    610                 615                 620                 


Glu Leu Phe Thr Ser Ser Asn Gln Ile Gly Leu Lys Thr Asp Val Thr 
625                 630                 635                 640 


Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Glu Cys Leu Ser Asp 
                645                 650                 655     


Glu Phe Cys Leu Asp Glu Lys Gln Glu Leu Ser Glu Lys Val Lys His 
            660                 665                 670         


Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Pro Asn Phe 
        675                 680                 685             


Arg Gly Ile Asn Arg Gln Leu Asp Arg Gly Trp Arg Gly Ser Thr Asp 
    690                 695                 700                 


Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val Thr 
705                 710                 715                 720 


Leu Leu Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys 
                725                 730                 735     


Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg Tyr Gln Leu Arg Gly 
            740                 745                 750         


Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg Tyr Asn 
        755                 760                 765             


Ala Lys His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu Trp Pro 
    770                 775                 780                 


Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn Arg Cys 
785                 790                 795                 800 


Ala Pro His Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys Arg Asp 
                805                 810                 815     


Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp Ile Asp 
            820                 825                 830         


Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile Phe 
        835                 840                 845             


Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu Glu Phe 
    850                 855                 860                 


Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val Lys Ile 
865                 870                 875                 880 


Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu Thr 
                885                 890                 895     


Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe Val 
            900                 905                 910         


Asn Ser Gln Tyr Asp Gln Leu Gln Ala Asp Thr Asn Ile Ala Met Ile 
        915                 920                 925             


His Ala Ala Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr Leu Pro 
    930                 935                 940                 


Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu Leu 
945                 950                 955                 960 


Glu Gly Arg Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg Asn Val 
                965                 970                 975     


Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser Cys Trp Asn Val Lys 
            980                 985                 990         


Gly His Val Asp Val Glu Glu Gln  Asn Asn Gln Arg Ser  Val Leu Val 
        995                 1000                 1005             


Val Pro  Glu Trp Glu Ala Glu  Val Ser Gln Glu Val  Arg Val Cys 
    1010                 1015                 1020             


Pro Gly  Arg Gly Tyr Ile Leu  Arg Val Thr Ala Tyr  Lys Glu Gly 
    1025                 1030                 1035             


Tyr Gly  Glu Gly Cys Val Thr  Ile His Glu Ile Glu  Asn Asn Thr 
    1040                 1045                 1050             


Asp Glu  Leu Lys Phe Ser Asn  Cys Val Glu Glu Glu  Ile Tyr Ser 
    1055                 1060                 1065             


Asn Asn  Thr Val Thr Cys Asn  Asp Tyr Thr Val Asn  Gln Glu Glu 
    1070                 1075                 1080             


Tyr Gly  Gly Ala Tyr Thr Ser  Arg Asn Arg Gly Tyr  Asn Glu Ala 
    1085                 1090                 1095             


Pro Ser  Val Pro Ala Asp Tyr  Ala Ser Val Tyr Glu  Glu Lys Ser 
    1100                 1105                 1110             


Tyr Thr  Asp Gly Arg Arg Glu  Asn Pro Cys Glu Phe  Asn Arg Gly 
    1115                 1120                 1125             


Tyr Arg  Asp Tyr Thr Pro Leu  Pro Val Gly Tyr Val  Thr Lys Glu 
    1130                 1135                 1140             


Leu Glu  Tyr Phe Pro Glu Thr  Asp Lys Val Trp Ile  Glu Ile Gly 
    1145                 1150                 1155             


Glu Thr  Glu Gly Thr Phe Ile  Val Asp Ser Val Glu  Leu Leu Leu 
    1160                 1165                 1170             


Met Glu  Glu 
    1175     


