                         SEQUENCE LISTING

<110>  SYNGENTA BIOTECHNOLOGY CHINA CO, LTD
       SYNGENTA CROP PROTECTION AG
 
<120>  CONTROL OF NOCTUID, CRAMBID, AND PYRALID PESTS

<130>  82218-WO-REG-ORG-P-1

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A BT29 protein

<400>  1

Met Glu Ile Asn Asn Gln Asn Gln Cys Val Pro Tyr Asn Cys Leu Asn 
1               5                   10                  15      


Asn Pro Glu Ser Glu Ile Leu Asn Val Ala Ile Phe Ser Ser Glu Gln 
            20                  25                  30          


Val Ala Glu Ile His Leu Lys Ile Thr Arg Leu Ile Leu Glu Asn Phe 
        35                  40                  45              


Leu Pro Gly Gly Ser Phe Ala Phe Gly Leu Phe Asp Leu Ile Trp Gly 
    50                  55                  60                  


Ile Phe Asn Glu Asp Gln Trp Ser Ala Phe Leu Arg Gln Val Glu Glu 
65                  70                  75                  80  


Leu Ile Asn Gln Arg Ile Thr Glu Phe Ala Arg Gly Gln Ala Ile Gln 
                85                  90                  95      


Arg Leu Val Gly Phe Gly Arg Ser Tyr Asp Glu Tyr Ile Leu Ala Leu 
            100                 105                 110         


Lys Glu Trp Glu Asn Asp Pro Asp Asn Pro Ala Ser Lys Glu Arg Val 
        115                 120                 125             


Arg Thr Arg Phe Arg Thr Thr Asp Asp Ala Leu Leu Thr Gly Val Pro 
    130                 135                 140                 


Leu Met Ala Ile Pro Gly Phe Glu Leu Ala Thr Leu Ser Val Tyr Ala 
145                 150                 155                 160 


Gln Ser Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ala Val Phe Phe 
                165                 170                 175     


Gly Glu Arg Trp Gly Leu Thr Gln Thr Asn Ile Asn Asp Leu Tyr Ser 
            180                 185                 190         


Arg Leu Lys Asn Ser Ile Arg Asp Tyr Thr Asn His Cys Val Arg Phe 
        195                 200                 205             


Tyr Asn Ile Gly Leu Gly Asn Leu Asn Val Ile Arg Pro Glu Tyr Tyr 
    210                 215                 220                 


Arg Phe Gln Arg Glu Leu Thr Ile Ser Val Leu Asp Leu Val Ala Leu 
225                 230                 235                 240 


Phe Pro Asn Tyr Asp Ile Arg Thr Tyr Pro Ile Pro Thr Lys Ser Gln 
                245                 250                 255     


Leu Thr Arg Glu Ile Tyr Thr Asp Pro Ile Ile Ser Pro Gly Ala Gln 
            260                 265                 270         


Ala Gly Tyr Thr Leu Gln Asp Val Leu Arg Glu Pro His Leu Met Asp 
        275                 280                 285             


Phe Leu Asn Arg Leu Ile Ile Tyr Thr Gly Glu Tyr Arg Gly Ile Arg 
    290                 295                 300                 


His Trp Ala Gly His Glu Val Glu Ser Ser Arg Thr Gly Met Met Thr 
305                 310                 315                 320 


Asn Ile Arg Phe Pro Leu Tyr Gly Thr Ala Ala Thr Ala Glu Pro Thr 
                325                 330                 335     


Arg Phe Ile Thr Pro Ser Thr Phe Pro Gly Leu Asn Leu Phe Tyr Arg 
            340                 345                 350         


Thr Leu Ser Ala Pro Ile Phe Arg Asp Glu Pro Gly Ala Asn Ile Ile 
        355                 360                 365             


Ile Arg Tyr Arg Thr Ser Leu Val Glu Gly Val Gly Phe Ile Gln Pro 
    370                 375                 380                 


Asn Asn Gly Glu Gln Leu Tyr Arg Val Arg Gly Thr Leu Asp Ser Leu 
385                 390                 395                 400 


Asp Gln Leu Pro Leu Glu Gly Glu Ser Ser Leu Thr Glu Tyr Ser His 
                405                 410                 415     


Arg Leu Cys His Val Arg Phe Ala Gln Ser Leu Arg Asn Ala Glu Pro 
            420                 425                 430         


Leu Asp Tyr Ala Arg Val Pro Met Phe Ser Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Pro Thr Asn Thr Ile Asp Pro Asp Val Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala Phe Asn Leu His Ser Gly Ala Thr Ile Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Asn Val Gly Ser Phe 
                485                 490                 495     


Gly Asp Met Arg Val Asn Ile Thr Ala Pro Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Val Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Gln Phe Tyr Thr Asn 
        515                 520                 525             


Ile Asn Gly Thr Thr Ile Asn Ile Gly Asn Phe Ser Ser Thr Met Asp 
    530                 535                 540                 


Ser Gly Asp Asp Leu Gln Tyr Gly Arg Phe Arg Val Ala Gly Phe Thr 
545                 550                 555                 560 


Thr Pro Phe Thr Phe Ser Asp Ala Met Ser Thr Phe Thr Ile Gly Ala 
                565                 570                 575     


Phe Ser Phe Ser Ser Asn Asn Glu Val Tyr Ile Asp Arg Ile Glu Phe 
            580                 585                 590         


Val Pro Ala Glu Val Thr Phe Glu Ala Glu Tyr Asp Leu Glu Lys Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Ser Asn Gln Ile Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr His Ile Asp Lys Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Cys Asp Glu Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Arg Gly Ile Asn Arg Gln Pro Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Ala Thr His Leu Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys 
865                 870                 875                 880 


Leu Glu Leu Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Lys Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Ala Ile Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr Ala Tyr Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Val Glu Glu Gln Asn Asn His 
            980                 985                 990         


Arg Ser Val Leu Val Val Pro Glu  Trp Glu Ala Glu Val  Ser Gln Glu 
        995                 1000                 1005             


Val Arg  Val Cys Pro Gly Arg  Gly Tyr Ile Leu Arg  Val Thr Ala 
    1010                 1015                 1020             


Tyr Lys  Glu Gly Tyr Gly Glu  Gly Cys Val Thr Ile  His Glu Ile 
    1025                 1030                 1035             


Glu Asp  Asn Thr Asp Glu Leu  Lys Phe Ser Asn Cys  Val Glu Glu 
    1040                 1045                 1050             


Glu Ile  Tyr Pro Asn Asn Thr  Val Thr Cys Asn Asp  Tyr Thr Ala 
    1055                 1060                 1065             


Thr Gln  Glu Glu Tyr Glu Gly  Thr Tyr Thr Ser Arg  Asn Arg Gly 
    1070                 1075                 1080             


Tyr Asp  Gly Ala Tyr Glu Ser  Asn Ser Ser Val Pro  Ala Asp Tyr 
    1085                 1090                 1095             


Ala Ser  Ala Tyr Glu Glu Lys  Ala Tyr Thr Asp Gly  Arg Arg Asp 
    1100                 1105                 1110             


Asn Thr  Cys Glu Ser Asn Arg  Gly Tyr Gly Asp Tyr  Thr Pro Leu 
    1115                 1120                 1125             


Pro Ala  Gly Tyr Val Thr Lys  Glu Leu Glu Tyr Phe  Pro Glu Thr 
    1130                 1135                 1140             


Asp Lys  Val Trp Ile Glu Ile  Gly Glu Thr Glu Gly  Thr Phe Ile 
    1145                 1150                 1155             


Val Asp  Ser Val Glu Leu Leu  Leu Met Glu Glu 
    1160                 1165                 


<210>  2
<211>  1169
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A BT29-BT22 chimeric protein

<400>  2

Met Glu Ile Asn Asn Gln Asn Gln Cys Val Pro Tyr Asn Cys Leu Asn 
1               5                   10                  15      


Asn Pro Glu Ser Glu Ile Leu Asn Val Ala Ile Phe Ser Ser Glu Gln 
            20                  25                  30          


Val Ala Glu Ile His Leu Lys Ile Thr Arg Leu Ile Leu Glu Asn Phe 
        35                  40                  45              


Leu Pro Gly Gly Ser Phe Ala Phe Gly Leu Phe Asp Leu Ile Trp Gly 
    50                  55                  60                  


Ile Phe Asn Glu Asp Gln Trp Ser Ala Phe Leu Arg Gln Val Glu Glu 
65                  70                  75                  80  


Leu Ile Asn Gln Arg Ile Thr Glu Phe Ala Arg Gly Gln Ala Ile Gln 
                85                  90                  95      


Arg Leu Val Gly Phe Gly Arg Ser Tyr Asp Glu Tyr Ile Leu Ala Leu 
            100                 105                 110         


Lys Glu Trp Glu Asn Asp Pro Asp Asn Pro Ala Ser Lys Glu Arg Val 
        115                 120                 125             


Arg Thr Arg Phe Arg Thr Thr Asp Asp Ala Leu Leu Thr Gly Val Pro 
    130                 135                 140                 


Leu Met Ala Ile Pro Gly Phe Glu Leu Ala Thr Leu Ser Val Tyr Ala 
145                 150                 155                 160 


Gln Ser Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ala Val Phe Phe 
                165                 170                 175     


Gly Glu Arg Trp Gly Leu Thr Gln Thr Asn Ile Asn Asp Leu Tyr Ser 
            180                 185                 190         


Arg Leu Lys Asn Ser Ile Arg Asp Tyr Thr Asn His Cys Val Arg Phe 
        195                 200                 205             


Tyr Asn Ile Gly Leu Gly Asn Leu Asn Val Ile Arg Pro Glu Tyr Tyr 
    210                 215                 220                 


Arg Phe Gln Arg Glu Leu Thr Ile Ser Val Leu Asp Leu Val Ala Leu 
225                 230                 235                 240 


Phe Pro Asn Tyr Asp Ile Arg Thr Tyr Pro Ile Pro Thr Lys Ser Gln 
                245                 250                 255     


Leu Thr Arg Glu Ile Tyr Thr Asp Pro Ile Ile Ser Pro Gly Ala Gln 
            260                 265                 270         


Ala Gly Tyr Thr Leu Gln Asp Val Leu Arg Glu Pro His Leu Met Asp 
        275                 280                 285             


Phe Leu Asn Arg Leu Ile Ile Tyr Thr Gly Glu Tyr Arg Gly Ile Arg 
    290                 295                 300                 


His Trp Ala Gly His Glu Val Glu Ser Ser Arg Thr Gly Met Met Thr 
305                 310                 315                 320 


Asn Ile Arg Phe Pro Leu Tyr Gly Thr Ala Ala Thr Ala Glu Pro Thr 
                325                 330                 335     


Arg Phe Ile Thr Pro Ser Thr Phe Pro Gly Leu Asn Leu Phe Tyr Arg 
            340                 345                 350         


Thr Leu Ser Ala Pro Ile Phe Arg Asp Glu Pro Gly Ala Asn Ile Ile 
        355                 360                 365             


Ile Arg Tyr Arg Thr Ser Leu Val Glu Gly Val Gly Phe Ile Gln Pro 
    370                 375                 380                 


Asn Asn Gly Glu Gln Leu Tyr Arg Val Arg Gly Thr Leu Asp Ser Leu 
385                 390                 395                 400 


Asp Gln Leu Pro Leu Glu Gly Glu Ser Ser Leu Thr Glu Tyr Ser His 
                405                 410                 415     


Arg Leu Cys His Val Arg Phe Ala Gln Ser Leu Arg Asn Ala Glu Pro 
            420                 425                 430         


Leu Asp Tyr Ala Arg Val Pro Met Phe Ser Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Pro Thr Asn Thr Ile Asp Pro Asp Val Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Lys Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Phe Ser Asn Val Asn Leu Asp Trp Asn Leu Ser Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Met Tyr Val Thr 
        515                 520                 525             


Ile Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asn 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asp 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Thr Lys Ala Ser Ser Leu Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Val Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Lys Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Ser Asn Gln Ile Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr His Ile Asp Lys Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Cys Asp Glu Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Arg Gly Ile Asn Arg Gln Pro Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Ala Thr His Leu Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys 
865                 870                 875                 880 


Leu Glu Leu Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Lys Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Ala Ile Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr Ala Tyr Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Val Glu Glu Gln Asn Asn His 
            980                 985                 990         


Arg Ser Val Leu Val Val Pro Glu  Trp Glu Ala Glu Val  Ser Gln Glu 
        995                 1000                 1005             


Val Arg  Val Cys Pro Gly Arg  Gly Tyr Ile Leu Arg  Val Thr Ala 
    1010                 1015                 1020             


Tyr Lys  Glu Gly Tyr Gly Glu  Gly Cys Val Thr Ile  His Glu Ile 
    1025                 1030                 1035             


Glu Asp  Asn Thr Asp Glu Leu  Lys Phe Ser Asn Cys  Val Glu Glu 
    1040                 1045                 1050             


Glu Ile  Tyr Pro Asn Asn Thr  Val Thr Cys Asn Asp  Tyr Thr Ala 
    1055                 1060                 1065             


Thr Gln  Glu Glu Tyr Glu Gly  Thr Tyr Thr Ser Arg  Asn Arg Gly 
    1070                 1075                 1080             


Tyr Asp  Gly Ala Tyr Glu Ser  Asn Ser Ser Val Pro  Ala Asp Tyr 
    1085                 1090                 1095             


Ala Ser  Ala Tyr Glu Glu Lys  Ala Tyr Thr Asp Gly  Arg Arg Asp 
    1100                 1105                 1110             


Asn Thr  Cys Glu Ser Asn Arg  Gly Tyr Gly Asp Tyr  Thr Pro Leu 
    1115                 1120                 1125             


Pro Ala  Gly Tyr Val Thr Lys  Glu Leu Glu Tyr Phe  Pro Glu Thr 
    1130                 1135                 1140             


Asp Lys  Val Trp Ile Glu Ile  Gly Glu Thr Glu Gly  Thr Phe Ile 
    1145                 1150                 1155             


Val Asp  Ser Val Glu Leu Leu  Leu Met Glu Glu 
    1160                 1165                 


<210>  3
<211>  1169
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A BT29-Cry1FA chimeric protein

<400>  3

Met Glu Ile Asn Asn Gln Asn Gln Cys Val Pro Tyr Asn Cys Leu Asn 
1               5                   10                  15      


Asn Pro Glu Ser Glu Ile Leu Asn Val Ala Ile Phe Ser Ser Glu Gln 
            20                  25                  30          


Val Ala Glu Ile His Leu Lys Ile Thr Arg Leu Ile Leu Glu Asn Phe 
        35                  40                  45              


Leu Pro Gly Gly Ser Phe Ala Phe Gly Leu Phe Asp Leu Ile Trp Gly 
    50                  55                  60                  


Ile Phe Asn Glu Asp Gln Trp Ser Ala Phe Leu Arg Gln Val Glu Glu 
65                  70                  75                  80  


Leu Ile Asn Gln Arg Ile Thr Glu Phe Ala Arg Gly Gln Ala Ile Gln 
                85                  90                  95      


Arg Leu Val Gly Phe Gly Arg Ser Tyr Asp Glu Tyr Ile Leu Ala Leu 
            100                 105                 110         


Lys Glu Trp Glu Asn Asp Pro Asp Asn Pro Ala Ser Lys Glu Arg Val 
        115                 120                 125             


Arg Thr Arg Phe Arg Thr Thr Asp Asp Ala Leu Leu Thr Gly Val Pro 
    130                 135                 140                 


Leu Met Ala Ile Pro Gly Phe Glu Leu Ala Thr Leu Ser Val Tyr Ala 
145                 150                 155                 160 


Gln Ser Ala Asn Leu His Leu Ala Leu Leu Arg Asp Ala Val Phe Phe 
                165                 170                 175     


Gly Glu Arg Trp Gly Leu Thr Gln Thr Asn Ile Asn Asp Leu Tyr Ser 
            180                 185                 190         


Arg Leu Lys Asn Ser Ile Arg Asp Tyr Thr Asn His Cys Val Arg Phe 
        195                 200                 205             


Tyr Asn Ile Gly Leu Gly Asn Leu Asn Val Ile Arg Pro Glu Tyr Tyr 
    210                 215                 220                 


Arg Phe Gln Arg Glu Leu Thr Ile Ser Val Leu Asp Leu Val Ala Leu 
225                 230                 235                 240 


Phe Pro Asn Tyr Asp Ile Arg Thr Tyr Pro Ile Pro Thr Lys Ser Gln 
                245                 250                 255     


Leu Thr Arg Glu Ile Tyr Thr Asp Pro Ile Ile Ser Pro Gly Ala Gln 
            260                 265                 270         


Ala Gly Tyr Thr Leu Gln Asp Val Leu Arg Glu Pro His Leu Met Asp 
        275                 280                 285             


Phe Leu Asn Arg Leu Ile Ile Tyr Thr Gly Glu Tyr Arg Gly Ile Arg 
    290                 295                 300                 


His Trp Ala Gly His Glu Val Glu Ser Ser Arg Thr Gly Met Met Thr 
305                 310                 315                 320 


Asn Ile Arg Phe Pro Leu Tyr Gly Thr Ala Ala Thr Ala Glu Pro Thr 
                325                 330                 335     


Arg Phe Ile Thr Pro Ser Thr Phe Pro Gly Leu Asn Leu Phe Tyr Arg 
            340                 345                 350         


Thr Leu Ser Ala Pro Ile Phe Arg Asp Glu Pro Gly Ala Asn Ile Ile 
        355                 360                 365             


Ile Arg Tyr Arg Thr Ser Leu Val Glu Gly Val Gly Phe Ile Gln Pro 
    370                 375                 380                 


Asn Asn Gly Glu Gln Leu Tyr Arg Val Arg Gly Thr Leu Asp Ser Leu 
385                 390                 395                 400 


Asp Gln Leu Pro Leu Glu Gly Glu Ser Ser Leu Thr Glu Tyr Ser His 
                405                 410                 415     


Arg Leu Cys His Val Arg Phe Ala Gln Ser Leu Arg Asn Ala Glu Pro 
            420                 425                 430         


Leu Asp Tyr Ala Arg Val Pro Met Phe Ser Trp Thr His Arg Ser Ala 
        435                 440                 445             


Thr Pro Thr Asn Thr Ile Asp Pro Asp Val Ile Thr Gln Ile Pro Leu 
    450                 455                 460                 


Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val Val Arg Gly Pro 
465                 470                 475                 480 


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Gly Gly Pro Phe 
                485                 490                 495     


Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro Gln Arg Tyr Arg 
            500                 505                 510         


Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg Ile Tyr Val Thr 
        515                 520                 525             


Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn Lys Thr Met Asp 
    530                 535                 540                 


Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr Ala Thr Ile Asn 
545                 550                 555                 560 


Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe Thr Val Gly Ala 
                565                 570                 575     


Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Phe Glu Leu 
            580                 585                 590         


Ile Pro Val Thr Ala Thr Phe Glu Ala Glu Tyr Asp Leu Glu Lys Ala 
        595                 600                 605             


Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Ser Asn Gln Ile Gly Leu 
    610                 615                 620                 


Lys Thr Asp Val Thr Asp Tyr His Ile Asp Lys Val Ser Asn Leu Val 
625                 630                 635                 640 


Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser 
                645                 650                 655     


Glu Lys Val Lys His Ala Lys Arg Leu Cys Asp Glu Arg Asn Leu Leu 
            660                 665                 670         


Gln Asp Pro Asn Phe Arg Gly Ile Asn Arg Gln Pro Asp Arg Gly Trp 
        675                 680                 685             


Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys 
    690                 695                 700                 


Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp Glu Cys Tyr Pro Thr 
705                 710                 715                 720 


Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg 
                725                 730                 735     


Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr 
            740                 745                 750         


Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn Val Pro Gly Thr 
        755                 760                 765             


Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly 
    770                 775                 780                 


Glu Pro Asn Arg Cys Ala Thr His Leu Glu Trp Asn Pro Asp Leu Asp 
785                 790                 795                 800 


Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His Ser His His Phe 
                805                 810                 815     


Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly 
            820                 825                 830         


Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu 
        835                 840                 845             


Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu 
    850                 855                 860                 


Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys 
865                 870                 875                 880 


Leu Glu Leu Glu Thr Asn Ile Val Tyr Lys Glu Ala Lys Lys Ser Val 
                885                 890                 895     


Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Arg Leu Gln Ala Asp Thr 
            900                 905                 910         


Asn Ile Ala Ile Ile His Ala Ala Asp Lys Arg Val His Ser Ile Arg 
        915                 920                 925             


Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala 
    930                 935                 940                 


Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr Ala Tyr Ser Leu Tyr 
945                 950                 955                 960 


Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser 
                965                 970                 975     


Cys Trp Asn Val Lys Gly His Val Asp Val Glu Glu Gln Asn Asn His 
            980                 985                 990         


Arg Ser Val Leu Val Val Pro Glu  Trp Glu Ala Glu Val  Ser Gln Glu 
        995                 1000                 1005             


Val Arg  Val Cys Pro Gly Arg  Gly Tyr Ile Leu Arg  Val Thr Ala 
    1010                 1015                 1020             


Tyr Lys  Glu Gly Tyr Gly Glu  Gly Cys Val Thr Ile  His Glu Ile 
    1025                 1030                 1035             


Glu Asp  Asn Thr Asp Glu Leu  Lys Phe Ser Asn Cys  Val Glu Glu 
    1040                 1045                 1050             


Glu Ile  Tyr Pro Asn Asn Thr  Val Thr Cys Asn Asp  Tyr Thr Ala 
    1055                 1060                 1065             


Thr Gln  Glu Glu Tyr Glu Gly  Thr Tyr Thr Ser Arg  Asn Arg Gly 
    1070                 1075                 1080             


Tyr Asp  Gly Ala Tyr Glu Ser  Asn Ser Ser Val Pro  Ala Asp Tyr 
    1085                 1090                 1095             


Ala Ser  Ala Tyr Glu Glu Lys  Ala Tyr Thr Asp Gly  Arg Arg Asp 
    1100                 1105                 1110             


Asn Thr  Cys Glu Ser Asn Arg  Gly Tyr Gly Asp Tyr  Thr Pro Leu 
    1115                 1120                 1125             


Pro Ala  Gly Tyr Val Thr Lys  Glu Leu Glu Tyr Phe  Pro Glu Thr 
    1130                 1135                 1140             


Asp Lys  Val Trp Ile Glu Ile  Gly Glu Thr Glu Gly  Thr Phe Ile 
    1145                 1150                 1155             


Val Asp  Ser Val Glu Leu Leu  Leu Met Glu Glu 
    1160                 1165                 


