                         SEQUENCE LISTING

<110>  Seattle Children's Research Institute
 
<120>  HYBRID AND TRUNCATED IMMUNE CELL PROTEINS

<130>  S281-0024PCT / SCRI.353WO

<150>  US63/138,234
<151>  2021-01-15

<160>  217   

<170>  PatentIn version 3.5

<210>  1
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  2
<211>  309
<212>  PRT
<213>  Mus musculus

<400>  2

Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210>  3
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  4
<211>  594
<212>  DNA
<213>  Mus musculus

<400>  4
atggagggtg aaggagtgca gcctctcgac gagaacctcg aaaatggcag taggccccgg       60

ttcaaatgga agaagacact gcggctggta gtgtctggaa taaaaggtgc aggtatgttg      120

ctgtgcttca tctatgtttg ccttcaattg agctctagcc ctgctaaaga cccacctatc      180

cagcggctca ggggagcagt aacacgctgt gaagacggtc agttgtttat tagttcttac      240

aagaacgagt accagacaat ggaagttcaa aataattctg tcgtcatcaa atgtgacggg      300

ttgtatataa tatatctgaa aggcagtttt tttcaagagg taaagatcga cctgcacttt      360

cgagaggatc ataatccaat ttctatacct atgctcaatg atgggaggcg catcgtcttc      420

accgtagtgg ccagcctcgc ttttaaggac aaagtttatc tcactgttaa tgcacccgat      480

acactgtgcg agcacctgca aattaacgat ggagagctta tagttgtgca acttactcct      540

ggatattgcg ctcccgaagg gtcttatcat agtactgtaa accaagtacc cctt            594


<210>  5
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  6
<211>  780
<212>  DNA
<213>  Mus musculus

<400>  6
atgatagaga cttattccca gcccagccct agaagtgttg caaccgggct cccagcctct       60

atgaagattt tcatgtatct gctgaccgtc tttctcatca ctcagatgat tgggagtgtc      120

ctgttcgcgg tctatctgca taggcgcctg gacaaggtcg aagaggaggt caacctgcac      180

gaggactttg tctttatcaa gaagttgaag cggtgcaaca agggcgaagg atctctgagc      240

ctcctgaact gtgaagaaat gcgccgacag tttgaggatc tggtaaaaga cataacgctt      300

aacaaggaag aaaagaagga gaattctttc gagatgcaac gcggcgatga ggatccacag      360

atcgccgcgc acgtcgtctc agaggccaat tcaaacgcag cctcagtact tcaatgggcg      420

aaaaaggggt attacaccat gaagtctaat cttgttatgc tagagaatgg gaagcagctg      480

acagtgaagc gcgaggggct gtactatgta tatacacaag ttaccttctg cagcaatagg      540

gagccaagta gccagcgccc ctttatcgtg gggctgtggc tcaaacccag cagcggctcc      600

gaacgtattc tgcttaaggc tgccaacact cacagttcaa gccagctgtg cgagcagcag      660

tccgtacatc ttggcggagt ctttgagctc caggctggcg cctcagtgtt cgtgaacgtt      720

accgaagctt ctcaggttat tcaccgggtg ggcttttctt cctttggact gctgaaactc      780


<210>  7
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  8
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  9
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  10
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  11
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  12
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210>  13
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  14
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Arg Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  15
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr Ser Thr Leu Gly Ser Cys Pro Glu Arg Cys Ala 
            180                 185                 190         


Ala Val Cys Gly Trp Arg Gln Met Phe Trp Val Gln Val Leu Leu Ala 
        195                 200                 205             


Gly Leu Val Val Pro Leu Leu Leu Gly Ala Thr Leu Thr Tyr Thr Tyr 
    210                 215                 220                 


Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala Gly 
225                 230                 235                 240 


Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp 
                245                 250                 255     


Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys 
            260                 265                 270         


Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr 
        275                 280                 285             


Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro 
    290                 295                 300                 


Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser 
305                 310                 315                 320 


Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr 
                325                 330                 335     


Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg 
            340                 345                 350         


Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile 
        355                 360                 365             


Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln 
    370                 375                 380                 


Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met 
385                 390                 395                 400 


Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly 
                405                 410                 415     


Pro 
    


<210>  16
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  17
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  18
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  19
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  20
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  21
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  22
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln 
        35                  40                  45              


Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His 
    50                  55                  60                  


Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln 
65                  70                  75                  80  


Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met 
                85                  90                  95      


Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile 
            100                 105                 110         


Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn 
        115                 120                 125             


Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly 
    130                 135                 140                 


Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly 
145                 150                 155                 160 


Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro 
                165                 170                 175     


Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu 
            180                 185                 190         


Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu 
        195                 200                 205             


Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu 
    210                 215                 220                 


His Pro Gly Gln Glu 
225                 


<210>  23
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asp Pro Lys Gly Leu Leu Ser Leu Thr Phe Val Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Gly Ala Ser Tyr Gly Thr Gly Gly Arg Met Met Asn Cys 
            20                  25                  30          


Pro Lys Ile Leu Arg Gln Leu Gly Ser Lys Val Leu Leu Pro Leu Thr 
        35                  40                  45              


Tyr Glu Arg Ile Asn Lys Ser Met Asn Lys Ser Ile His Ile Val Val 
    50                  55                  60                  


Thr Met Ala Lys Ser Leu Glu Asn Ser Val Glu Asn Lys Ile Val Ser 
65                  70                  75                  80  


Leu Asp Pro Ser Glu Ala Gly Pro Pro Arg Tyr Leu Gly Asp Arg Tyr 
                85                  90                  95      


Lys Phe Tyr Leu Glu Asn Leu Thr Leu Gly Ile Arg Glu Ser Arg Lys 
            100                 105                 110         


Glu Asp Glu Gly Trp Tyr Leu Met Thr Leu Glu Lys Asn Val Ser Val 
        115                 120                 125             


Gln Arg Phe Cys Leu Gln Leu Arg Leu Tyr Glu Gln Val Ser Thr Pro 
    130                 135                 140                 


Glu Ile Lys Val Leu Asn Lys Thr Gln Glu Asn Gly Thr Cys Thr Leu 
145                 150                 155                 160 


Ile Leu Gly Cys Thr Val Glu Lys Gly Asp His Val Ala Tyr Ser Trp 
                165                 170                 175     


Ser Glu Lys Ala Gly Thr His Pro Leu Asn Pro Ala Asn Ser Ser His 
            180                 185                 190         


Leu Leu Ser Leu Thr Leu Gly Pro Gln His Ala Asp Asn Ile Tyr Ile 
        195                 200                 205             


Cys Thr Val Ser Asn Pro Ile Ser Asn Asn Ser Gln Thr Phe Ser Pro 
    210                 215                 220                 


Trp Pro Gly Cys Arg Thr Asp Pro Ser Glu Thr Lys Pro Trp Ala Val 
225                 230                 235                 240 


Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile Met Val Val 
                245                 250                 255     


Ile Leu Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr 
            260                 265                 270         


Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly 
        275                 280                 285             


Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr 
    290                 295                 300                 


Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu 
305                 310                 315                 320 


Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 
                325                 330                 335 


<210>  24
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  25
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  26
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90              


<210>  27
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  28
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  29
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210>  30
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210>  31
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Pro Gly Gly Gly Pro Glu Met Asp Asp Tyr Met Glu Thr Leu Lys 
1               5                   10                  15      


Asp Glu Glu Asp Ala Leu Trp Glu Asn Val Glu Cys Asn Arg His Met 
            20                  25                  30          


Leu Ser Arg Tyr Ile Asn Pro Ala Lys Leu Thr Pro Tyr Leu Arg Gln 
        35                  40                  45              


Cys Lys Val Ile Asp Glu Gln Asp Glu Asp Glu Val Leu Asn Ala Pro 
    50                  55                  60                  


Met Leu Pro Ser Lys Ile Asn Arg Ala Gly Arg Leu Leu Asp Ile Leu 
65                  70                  75                  80  


His Thr Lys Gly Gln Arg Gly Tyr Val Val Phe Leu Glu Ser Leu Glu 
                85                  90                  95      


Phe Tyr Tyr Pro Glu Leu Tyr Lys Leu Val Thr Gly Lys Glu Pro Thr 
            100                 105                 110         


Arg Arg Phe Ser Thr Ile Val Val Glu Glu Gly His Glu Gly Leu Thr 
        115                 120                 125             


His Phe Leu Met Asn Glu Val Ile Lys Leu Gln Gln Gln Met Lys Ala 
    130                 135                 140                 


Lys Asp Leu Gln Arg Cys Glu Leu Leu Ala Arg Leu Arg Gln Leu Glu 
145                 150                 155                 160 


Asp Glu Lys Lys Gln Met Thr Leu Thr Arg Val Glu Leu Leu Thr Phe 
                165                 170                 175     


Gln Glu Arg Tyr Tyr Lys Met Lys Glu Glu Arg Asp Ser Tyr Asn Asp 
            180                 185                 190         


Glu Leu Val Lys Val Lys Asp Asp Asn Tyr Asn Leu Ala Met Arg Tyr 
        195                 200                 205             


Ala Gln Leu Ser Glu Glu Lys Asn Met Ala Val Met Arg Ser Arg Asp 
    210                 215                 220                 


Leu Gln Leu Glu Ile Asp Gln Leu Lys His Arg Leu Asn Lys Met Glu 
225                 230                 235                 240 


Glu Glu Cys Lys Leu Glu Arg Asn Gln Ser Leu Lys Leu Lys Asn Asp 
                245                 250                 255     


Ile Glu Asn Arg Pro Lys Lys Glu Gln Val Leu Glu Leu Glu Arg Glu 
            260                 265                 270         


Asn Glu Met Leu Lys Thr Lys Asn Gln Glu Leu Gln Ser Ile Ile Gln 
        275                 280                 285             


Ala Gly Lys Arg Ser Leu Pro Asp Ser Asp Lys Ala Ile Leu Asp Ile 
    290                 295                 300                 


Leu Glu His Asp Arg Lys Glu Ala Leu Glu Asp Arg Gln Glu Leu Val 
305                 310                 315                 320 


Asn Arg Ile Tyr Asn Leu Gln Glu Glu Ala Arg Gln Ala Glu Glu Leu 
                325                 330                 335     


Arg Asp Lys Tyr Leu Glu Glu Lys Glu Asp Leu Glu Leu Lys Cys Ser 
            340                 345                 350         


Thr Leu Gly Lys Asp Cys Glu Met Tyr Lys His Arg Met Asn Thr Val 
        355                 360                 365             


Met Leu Gln Leu Glu Glu Val Glu Arg Glu Arg Asp Gln Ala Phe His 
    370                 375                 380                 


Ser Arg Asp Glu Ala Gln Thr Gln Tyr Ser Gln Cys Leu Ile Glu Lys 
385                 390                 395                 400 


Asp Lys Tyr Arg Lys Gln Ile Arg Glu Leu Glu Glu Lys Asn Asp Glu 
                405                 410                 415     


Met Arg Ile Glu Met Val Arg Arg Glu Ala Cys Ile Val Asn Leu Glu 
            420                 425                 430         


Ser Lys Leu Arg Arg Leu Ser Lys Asp Ser Asn Asn Leu Asp Gln Ser 
        435                 440                 445             


Leu Pro Arg Asn Leu Pro Val Thr Ile Ile Ser Gln Asp Phe Gly Asp 
    450                 455                 460                 


Ala Ser Pro Arg Thr Asn Gly Gln Glu Ala Asp Asp Ser Ser Thr Ser 
465                 470                 475                 480 


Glu Glu Ser Pro Glu Asp Ser Lys Tyr Phe Leu Pro Tyr His Pro Pro 
                485                 490                 495     


Gln Arg Arg Met Asn Leu Lys Gly Ile Gln Leu Gln Arg Ala Lys Ser 
            500                 505                 510         


Pro Ile Ser Leu Lys Arg Thr Ser Asp Phe Gln Ala Lys Gly His Glu 
        515                 520                 525             


Glu Glu Gly Thr Asp Ala Ser Pro Ser Ser Cys Gly Ser Leu Pro Ile 
    530                 535                 540                 


Thr Asn Ser Phe Thr Lys Met Gln Pro Pro Arg Ser Arg Ser Ser Ile 
545                 550                 555                 560 


Met Ser Ile Thr Ala Glu Pro Pro Gly Asn Asp Ser Ile Val Arg Arg 
                565                 570                 575     


Tyr Lys Glu Asp Ala Pro His Arg Ser Thr Val Glu Glu Asp Asn Asp 
            580                 585                 590         


Ser Gly Gly Phe Asp Ala Leu Asp Leu Asp Asp Asp Ser His Glu Arg 
        595                 600                 605             


Tyr Ser Phe Gly Pro Ser Ser Ile His Ser Ser Ser Ser Ser His Gln 
    610                 615                 620                 


Ser Glu Gly Leu Asp Ala Tyr Asp Leu Glu Gln Val Asn Leu Met Phe 
625                 630                 635                 640 


Arg Lys Phe Ser Leu Glu Arg Pro Phe Arg Pro Ser Val Thr Ser Val 
                645                 650                 655     


Gly His Val Arg Gly Pro Gly Pro Ser Val Gln His Thr Thr Leu Asn 
            660                 665                 670         


Gly Asp Ser Leu Thr Ser Gln Leu Thr Leu Leu Gly Gly Asn Ala Arg 
        675                 680                 685             


Gly Ser Phe Val His Ser Val Lys Pro Gly Ser Leu Ala Glu Lys Ala 
    690                 695                 700                 


Gly Leu Arg Glu Gly His Gln Leu Leu Leu Leu Glu Gly Cys Ile Arg 
705                 710                 715                 720 


Gly Glu Arg Gln Ser Val Pro Leu Asp Thr Cys Thr Lys Glu Glu Ala 
                725                 730                 735     


His Trp Thr Ile Gln Arg Cys Ser Gly Pro Val Thr Leu His Tyr Lys 
            740                 745                 750         


Val Asn His Glu Gly Tyr Arg Lys Leu Val Lys Asp Met Glu Asp Gly 
        755                 760                 765             


Leu Ile Thr Ser Gly Asp Ser Phe Tyr Ile Arg Leu Asn Leu Asn Ile 
    770                 775                 780                 


Ser Ser Gln Leu Asp Ala Cys Thr Met Ser Leu Lys Cys Asp Asp Val 
785                 790                 795                 800 


Val His Val Arg Asp Thr Met Tyr Gln Asp Arg His Glu Trp Leu Cys 
                805                 810                 815     


Ala Arg Val Asp Pro Phe Thr Asp His Asp Leu Asp Met Gly Thr Ile 
            820                 825                 830         


Pro Ser Tyr Ser Arg Ala Gln Gln Leu Leu Leu Val Lys Leu Gln Arg 
        835                 840                 845             


Leu Met His Arg Gly Ser Arg Glu Glu Val Asp Gly Thr His His Thr 
    850                 855                 860                 


Leu Arg Ala Leu Arg Asn Thr Leu Gln Pro Glu Glu Ala Leu Ser Thr 
865                 870                 875                 880 


Ser Asp Pro Arg Val Ser Pro Arg Leu Ser Arg Ala Ser Phe Leu Phe 
                885                 890                 895     


Gly Gln Leu Leu Gln Phe Val Ser Arg Ser Glu Asn Lys Tyr Lys Arg 
            900                 905                 910         


Met Asn Ser Asn Glu Arg Val Arg Ile Ile Ser Gly Ser Pro Leu Gly 
        915                 920                 925             


Ser Leu Ala Arg Ser Ser Leu Asp Ala Thr Lys Leu Leu Thr Glu Lys 
    930                 935                 940                 


Gln Glu Glu Leu Asp Pro Glu Ser Glu Leu Gly Lys Asn Leu Ser Leu 
945                 950                 955                 960 


Ile Pro Tyr Ser Leu Val Arg Ala Phe Tyr Cys Glu Arg Arg Arg Pro 
                965                 970                 975     


Val Leu Phe Thr Pro Thr Val Leu Ala Lys Thr Leu Val Gln Arg Leu 
            980                 985                 990         


Leu Asn Ser Gly Gly Ala Met Glu  Phe Thr Ile Cys Lys  Ser Asp Ile 
        995                 1000                 1005             


Val Thr  Arg Asp Glu Phe Leu  Arg Arg Gln Lys Thr  Glu Thr Ile 
    1010                 1015                 1020             


Ile Tyr  Ser Arg Glu Lys Asn  Pro Asn Ala Phe Glu  Cys Ile Ala 
    1025                 1030                 1035             


Pro Ala  Asn Ile Glu Ala Val  Ala Ala Lys Asn Lys  His Cys Leu 
    1040                 1045                 1050             


Leu Glu  Ala Gly Ile Gly Cys  Thr Arg Asp Leu Ile  Lys Ser Asn 
    1055                 1060                 1065             


Ile Tyr  Pro Ile Val Leu Phe  Ile Arg Val Cys Glu  Lys Asn Ile 
    1070                 1075                 1080             


Lys Arg  Phe Arg Lys Leu Leu  Pro Arg Pro Glu Thr  Glu Glu Glu 
    1085                 1090                 1095             


Phe Leu  Arg Val Cys Arg Leu  Lys Glu Lys Glu Leu  Glu Ala Leu 
    1100                 1105                 1110             


Pro Cys  Leu Tyr Ala Thr Val  Glu Pro Asp Met Trp  Gly Ser Val 
    1115                 1120                 1125             


Glu Glu  Leu Leu Arg Val Val  Lys Asp Lys Ile Gly  Glu Glu Gln 
    1130                 1135                 1140             


Arg Lys  Thr Ile Trp Val Asp  Glu Asp Gln Leu 
    1145                 1150                 


<210>  32
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210>  33
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210>  34
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  35
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210>  36
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  37
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp 
        115                 120                 125             


Gly Pro Ser Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro 
    130                 135                 140                 


Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly 
145                 150                 155                 160 


Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala 
                165                 170                 175     


Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe 
            180                 185                 190         


Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu 
        195                 200                 205             


Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser 
    210                 215                 220                 


Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser 
225                 230                 235                 240 


Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu 
                245                 250                 255     


Asn Leu Gln Glu Leu Asn 
            260         


<210>  38
<211>  893
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Thr Glu Glu Phe Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile 
1               5                   10                  15      


His Val Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro 
            20                  25                  30          


Lys Thr Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Met 
        35                  40                  45              


Arg Met Val Thr Val Pro Pro Arg His Tyr Cys Thr Val Ala Asn Pro 
    50                  55                  60                  


Val Ser Arg Asp Ala Gln Gly Leu Val Leu Phe Asp Val Thr Gly Gln 
65                  70                  75                  80  


Val Arg Leu Arg His Ala Asp Leu Glu Ile Arg Leu Ala Gln Asp Pro 
                85                  90                  95      


Phe Pro Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu 
            100                 105                 110         


Gln Val Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp 
        115                 120                 125             


Phe Glu Asp Lys Asp Gly Asp Lys Val Val Ala Gly Asp Glu Trp Leu 
    130                 135                 140                 


Phe Glu Gly Pro Gly Thr Tyr Ile Pro Arg Lys Glu Val Glu Val Val 
145                 150                 155                 160 


Glu Ile Ile Gln Ala Thr Ile Ile Arg Gln Asn Gln Ala Leu Arg Leu 
                165                 170                 175     


Arg Ala Arg Lys Glu Cys Trp Asp Arg Asp Gly Lys Glu Arg Val Thr 
            180                 185                 190         


Gly Glu Glu Trp Leu Val Thr Thr Val Gly Ala Tyr Leu Pro Ala Val 
        195                 200                 205             


Phe Glu Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys 
    210                 215                 220                 


Thr Ala Leu His Leu Arg Ala Arg Arg Asn Phe Arg Asp Phe Arg Gly 
225                 230                 235                 240 


Val Ser Arg Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr 
                245                 250                 255     


Glu Ala His Val Pro Asp Val His Glu Glu Val Leu Gly Val Val Pro 
            260                 265                 270         


Ile Thr Thr Leu Gly Pro His Asn Tyr Cys Val Ile Leu Asp Pro Val 
        275                 280                 285             


Gly Pro Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly 
    290                 295                 300                 


Glu Lys Ser Phe Phe Leu Gln Pro Gly Glu Gln Leu Glu Gln Gly Ile 
305                 310                 315                 320 


Gln Asp Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Arg Ala 
                325                 330                 335     


Leu Gln Pro Leu Glu Glu Gly Glu Asp Glu Glu Lys Val Ser His Gln 
            340                 345                 350         


Ala Gly Asp His Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser 
        355                 360                 365             


Ala Lys Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Glu 
    370                 375                 380                 


Asn Glu Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala 
385                 390                 395                 400 


Val Ile Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu 
                405                 410                 415     


Lys Glu Leu Pro Pro Gly Val Glu Glu Leu Leu Asn Lys Gly Gln Asp 
            420                 425                 430         


Pro Leu Ala Asp Arg Gly Glu Lys Asp Thr Ala Lys Ser Leu Gln Pro 
        435                 440                 445             


Leu Ala Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His 
    450                 455                 460                 


Asn Ala Ala Val Gln Val Tyr Asp Tyr Arg Glu Lys Arg Ala Arg Val 
465                 470                 475                 480 


Val Phe Gly Pro Glu Leu Val Ser Leu Gly Pro Glu Glu Gln Phe Thr 
                485                 490                 495     


Val Leu Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg 
            500                 505                 510         


Ala Leu Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr 
        515                 520                 525             


Ile Glu Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn 
    530                 535                 540                 


Trp His Phe Glu Val Asn Asp Arg Lys Asp Pro Gln Glu Thr Ala Lys 
545                 550                 555                 560 


Leu Phe Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala 
                565                 570                 575     


Ser Arg Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His 
            580                 585                 590         


Lys Asn Ser Ala Arg Ile Ile Arg Thr Ala Val Phe Gly Phe Glu Thr 
        595                 600                 605             


Ser Glu Ala Lys Gly Pro Asp Gly Met Ala Leu Pro Arg Pro Arg Asp 
    610                 615                 620                 


Gln Ala Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val 
625                 630                 635                 640 


Gln Ser Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg 
                645                 650                 655     


Ser Val Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala 
            660                 665                 670         


Ala Lys His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu 
        675                 680                 685             


Glu Arg Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys 
    690                 695                 700                 


Glu Leu Leu Glu Leu Glu Ala Leu Ser Met Ala Val Glu Ser Thr Gly 
705                 710                 715                 720 


Thr Ala Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu 
                725                 730                 735     


Gly Glu Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala 
            740                 745                 750         


Ile Glu Thr Glu Ala Glu Leu Gln Arg Val Gln Lys Val Arg Glu Leu 
        755                 760                 765             


Glu Leu Val Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala 
    770                 775                 780                 


Gln Gln Leu Ala Glu Val Glu Val Lys Lys Phe Lys Gln Met Thr Glu 
785                 790                 795                 800 


Ala Ile Gly Pro Ser Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu 
                805                 810                 815     


Met Gln Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile 
            820                 825                 830         


Thr Asp Gly Ser Thr Pro Ile Asn Leu Phe Asn Thr Ala Phe Gly Leu 
        835                 840                 845             


Leu Gly Met Gly Pro Glu Gly Gln Pro Leu Gly Arg Arg Val Ala Ser 
    850                 855                 860                 


Gly Pro Ser Pro Gly Glu Gly Ile Ser Pro Gln Ser Ala Gln Ala Pro 
865                 870                 875                 880 


Gln Ala Pro Gly Asp Asn His Val Val Pro Val Leu Arg 
                885                 890             


<210>  39
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  40
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Asn Met Arg Cys Val Asp Cys Gly Thr Cys Leu Gly His Thr 
1               5                   10                  15      


Arg Arg His Pro Thr Leu Phe Trp Gly Lys Thr Leu Pro Gly Leu Thr 
            20                  25                  30          


Pro Val Ala Ala Pro Ala Pro Gln Pro Ala Gln Cys Pro Pro Gly Ser 
        35                  40                  45              


Glu Glu Asp Ala Pro Ala Thr Gln Pro Gly Pro Gln Leu Ala Gly Pro 
    50                  55                  60                  


Asp Pro Pro Trp Ala Pro Val Phe Cys Arg Arg Leu Ala Arg Ala Gly 
65                  70                  75                  80  


His Ile Glu Leu Cys Asn Ala Val Gly Cys Val Leu Trp Ser Cys Pro 
                85                  90                  95      


Arg Ser Pro Gly Arg Gly His Ala Val Gly Gln Gly Leu Glu Gly Gly 
            100                 105                 110         


Gly Gly Cys Pro Trp Ala Thr Pro Pro Ser Leu Gly Gly Ala Asp Phe 
        115                 120                 125             


Cys Asn Thr Lys Tyr Ser Leu Trp Gln Lys Lys Cys Leu 
    130                 135                 140     


<210>  41
<211>  2471
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Thr Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Leu Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp His Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  42
<211>  2321
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Val 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


<210>  43
<211>  1999
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Cys 
1               5                   10                  15      


Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro Glu 
            20                  25                  30          


Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln Gly 
        35                  40                  45              


Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe Pro 
    50                  55                  60                  


Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys Gln 
65                  70                  75                  80  


Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro Leu 
                85                  90                  95      


Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu Arg 
            100                 105                 110         


Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser Lys 
        115                 120                 125             


Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser Cys 
    130                 135                 140                 


Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys Ser 
145                 150                 155                 160 


Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro Gln 
                165                 170                 175     


Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu Arg 
            180                 185                 190         


Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly Thr 
        195                 200                 205             


Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val Gly 
    210                 215                 220                 


Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro Arg 
225                 230                 235                 240 


Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp Ser 
                245                 250                 255     


Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Gly Cys 
            260                 265                 270         


Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly Gly 
        275                 280                 285             


Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu Thr 
    290                 295                 300                 


Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Ala Gln 
305                 310                 315                 320 


Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala Gly 
                325                 330                 335     


Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys Glu 
            340                 345                 350         


Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser Thr 
        355                 360                 365             


Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly Arg 
    370                 375                 380                 


Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro Cys 
385                 390                 395                 400 


His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr Leu 
                405                 410                 415     


Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp Leu 
            420                 425                 430         


Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His Gly 
        435                 440                 445             


Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro Pro 
    450                 455                 460                 


Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu Ser 
465                 470                 475                 480 


Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr Phe 
                485                 490                 495     


His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val Glu 
            500                 505                 510         


Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys His 
        515                 520                 525             


Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser Gly 
    530                 535                 540                 


Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys Ala 
545                 550                 555                 560 


Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys Cys 
                565                 570                 575     


Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu Cys 
            580                 585                 590         


Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro Gly 
        595                 600                 605             


Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys Glu 
    610                 615                 620                 


Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys Lys 
625                 630                 635                 640 


Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro Gly 
                645                 650                 655     


Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys Gln 
            660                 665                 670         


Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys Glu 
        675                 680                 685             


Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly Thr 
    690                 695                 700                 


Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly Tyr 
705                 710                 715                 720 


Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly Pro 
                725                 730                 735     


Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr Cys 
            740                 745                 750         


Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr Asp 
        755                 760                 765             


Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn Arg 
    770                 775                 780                 


Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro Arg 
785                 790                 795                 800 


Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg Asn 
                805                 810                 815     


Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys Pro 
            820                 825                 830         


Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys Ala 
        835                 840                 845             


Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro Ser 
    850                 855                 860                 


Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn Leu 
865                 870                 875                 880 


Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp Val 
                885                 890                 895     


Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro Ser 
            900                 905                 910         


Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln Asp 
        915                 920                 925             


His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr Cys 
    930                 935                 940                 


Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr Asp 
945                 950                 955                 960 


Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro Cys 
                965                 970                 975     


His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys Ala 
            980                 985                 990         


Cys Pro Pro Gly Phe Val Gly Leu  Arg Cys Glu Gly Asp  Val Asp Glu 
        995                 1000                 1005             


Cys Leu  Asp Gln Pro Cys His  Pro Thr Gly Thr Ala  Ala Cys His 
    1010                 1015                 1020             


Ser Leu  Ala Asn Ala Phe Tyr  Cys Gln Cys Leu Pro  Gly His Thr 
    1025                 1030                 1035             


Gly Gln  Trp Cys Glu Val Glu  Ile Asp Pro Cys His  Ser Gln Pro 
    1040                 1045                 1050             


Cys Phe  His Gly Gly Thr Cys  Glu Ala Thr Ala Gly  Ser Pro Leu 
    1055                 1060                 1065             


Gly Phe  Ile Cys His Cys Pro  Lys Gly Phe Glu Gly  Pro Thr Cys 
    1070                 1075                 1080             


Ser His  Arg Ala Pro Ser Cys  Gly Phe His His Cys  His His Gly 
    1085                 1090                 1095             


Gly Leu  Cys Leu Pro Ser Pro  Lys Pro Gly Phe Pro  Pro Arg Cys 
    1100                 1105                 1110             


Ala Cys  Leu Ser Gly Tyr Gly  Gly Pro Asp Cys Leu  Thr Pro Pro 
    1115                 1120                 1125             


Ala Pro  Lys Gly Cys Gly Pro  Pro Ser Pro Cys Leu  Tyr Asn Gly 
    1130                 1135                 1140             


Ser Cys  Ser Glu Thr Thr Gly  Leu Gly Gly Pro Gly  Phe Arg Cys 
    1145                 1150                 1155             


Ser Cys  Pro His Ser Ser Pro  Gly Pro Arg Cys Gln  Lys Pro Gly 
    1160                 1165                 1170             


Ala Lys  Gly Cys Glu Gly Arg  Ser Gly Asp Gly Ala  Cys Asp Ala 
    1175                 1180                 1185             


Gly Cys  Ser Gly Pro Gly Gly  Asn Trp Asp Gly Gly  Asp Cys Ser 
    1190                 1195                 1200             


Leu Gly  Val Pro Asp Pro Trp  Lys Gly Cys Pro Ser  His Ser Arg 
    1205                 1210                 1215             


Cys Trp  Leu Leu Phe Arg Asp  Gly Gln Cys His Pro  Gln Cys Asp 
    1220                 1225                 1230             


Ser Glu  Glu Cys Leu Phe Asp  Gly Tyr Asp Cys Glu  Thr Pro Pro 
    1235                 1240                 1245             


Ala Cys  Thr Pro Ala Tyr Asp  Gln Tyr Cys His Asp  His Phe His 
    1250                 1255                 1260             


Asn Gly  His Cys Glu Lys Gly  Cys Asn Thr Ala Glu  Cys Gly Trp 
    1265                 1270                 1275             


Asp Gly  Gly Asp Cys Arg Pro  Glu Asp Gly Asp Pro  Glu Trp Gly 
    1280                 1285                 1290             


Pro Ser  Leu Ala Leu Leu Val  Val Leu Ser Pro Pro  Ala Leu Asp 
    1295                 1300                 1305             


Gln Gln  Leu Phe Ala Leu Ala  Arg Val Leu Ser Leu  Thr Leu Arg 
    1310                 1315                 1320             


Val Gly  Leu Trp Val Arg Lys  Asp Arg Asp Gly Arg  Asp Met Val 
    1325                 1330                 1335             


Tyr Pro  Tyr Pro Gly Ala Arg  Ala Glu Glu Lys Leu  Gly Gly Thr 
    1340                 1345                 1350             


Arg Asp  Pro Thr Tyr Gln Glu  Arg Ala Ala Pro Gln  Thr Gln Pro 
    1355                 1360                 1365             


Leu Gly  Lys Glu Thr Asp Ser  Leu Ser Ala Gly Phe  Val Val Val 
    1370                 1375                 1380             


Met Gly  Val Asp Leu Ser Arg  Cys Gly Pro Asp His  Pro Ala Ser 
    1385                 1390                 1395             


Arg Cys  Pro Trp Asp Pro Gly  Leu Leu Leu Arg Phe  Leu Ala Ala 
    1400                 1405                 1410             


Met Ala  Ala Val Gly Ala Leu  Glu Pro Leu Leu Pro  Gly Pro Leu 
    1415                 1420                 1425             


Leu Ala  Val His Pro His Ala  Gly Thr Ala Pro Pro  Ala Asn Gln 
    1430                 1435                 1440             


Leu Pro  Trp Pro Val Leu Cys  Ser Pro Val Ala Gly  Val Ile Leu 
    1445                 1450                 1455             


Leu Ala  Leu Gly Ala Leu Leu  Val Leu Gln Leu Ile  Arg Arg Arg 
    1460                 1465                 1470             


Arg Arg  Glu His Gly Ala Leu  Trp Leu Pro Pro Gly  Phe Thr Arg 
    1475                 1480                 1485             


Arg Pro  Arg Thr Gln Ser Ala  Pro His Arg Arg Arg  Pro Pro Leu 
    1490                 1495                 1500             


Gly Glu  Asp Ser Ile Gly Leu  Lys Ala Leu Lys Pro  Lys Ala Glu 
    1505                 1510                 1515             


Val Asp  Glu Asp Gly Val Val  Met Cys Ser Gly Pro  Glu Glu Gly 
    1520                 1525                 1530             


Glu Glu  Ala Glu Glu Thr Gly  Pro Pro Ser Thr Cys  Gln Leu Trp 
    1535                 1540                 1545             


Ser Leu  Ser Gly Gly Cys Gly  Ala Leu Pro Gln Ala  Ala Met Leu 
    1550                 1555                 1560             


Thr Pro  Pro Gln Glu Ser Glu  Met Glu Ala Pro Asp  Leu Asp Thr 
    1565                 1570                 1575             


Arg Gly  Pro Asp Gly Val Thr  Pro Leu Met Ser Ala  Val Cys Cys 
    1580                 1585                 1590             


Gly Glu  Val Gln Ser Gly Thr  Phe Gln Gly Ala Trp  Leu Gly Cys 
    1595                 1600                 1605             


Pro Glu  Pro Trp Glu Pro Leu  Leu Asp Gly Gly Ala  Cys Pro Gln 
    1610                 1615                 1620             


Ala His  Thr Val Gly Thr Gly  Glu Thr Pro Leu His  Leu Ala Ala 
    1625                 1630                 1635             


Arg Phe  Ser Arg Pro Thr Ala  Ala Arg Arg Leu Leu  Glu Ala Gly 
    1640                 1645                 1650             


Ala Asn  Pro Asn Gln Pro Asp  Arg Ala Gly Arg Thr  Pro Leu His 
    1655                 1660                 1665             


Ala Ala  Val Ala Ala Asp Ala  Arg Glu Val Cys Gln  Leu Leu Leu 
    1670                 1675                 1680             


Arg Ser  Arg Gln Thr Ala Val  Asp Ala Arg Thr Glu  Asp Gly Thr 
    1685                 1690                 1695             


Thr Pro  Leu Met Leu Ala Ala  Arg Leu Ala Val Glu  Asp Leu Val 
    1700                 1705                 1710             


Glu Glu  Leu Ile Ala Ala Gln  Ala Asp Val Gly Ala  Arg Asp Lys 
    1715                 1720                 1725             


Trp Gly  Lys Thr Ala Leu His  Trp Ala Ala Ala Val  Asn Asn Ala 
    1730                 1735                 1740             


Arg Ala  Ala Arg Ser Leu Leu  Gln Ala Gly Ala Asp  Lys Asp Ala 
    1745                 1750                 1755             


Gln Asp  Asn Arg Glu Gln Thr  Pro Leu Phe Leu Ala  Ala Arg Glu 
    1760                 1765                 1770             


Gly Ala  Val Glu Val Ala Gln  Leu Leu Leu Gly Leu  Gly Ala Ala 
    1775                 1780                 1785             


Arg Glu  Leu Arg Asp Gln Ala  Gly Leu Ala Pro Ala  Asp Val Ala 
    1790                 1795                 1800             


His Gln  Arg Asn His Trp Asp  Leu Leu Thr Leu Leu  Glu Gly Ala 
    1805                 1810                 1815             


Gly Pro  Pro Glu Ala Arg His  Lys Ala Thr Pro Gly  Arg Glu Ala 
    1820                 1825                 1830             


Gly Pro  Phe Pro Arg Ala Arg  Thr Val Ser Val Ser  Val Pro Pro 
    1835                 1840                 1845             


His Gly  Gly Gly Ala Leu Pro  Arg Cys Arg Thr Leu  Ser Ala Gly 
    1850                 1855                 1860             


Ala Gly  Pro Arg Gly Gly Gly  Ala Cys Leu Gln Ala  Arg Thr Trp 
    1865                 1870                 1875             


Ser Val  Asp Leu Ala Ala Arg  Gly Gly Gly Ala Tyr  Ser His Cys 
    1880                 1885                 1890             


Arg Ser  Leu Ser Gly Val Gly  Ala Gly Gly Gly Pro  Thr Pro Arg 
    1895                 1900                 1905             


Gly Arg  Arg Phe Ser Ala Gly  Met Arg Gly Pro Arg  Pro Asn Pro 
    1910                 1915                 1920             


Ala Ile  Met Arg Gly Arg Tyr  Gly Val Ala Ala Gly  Arg Gly Gly 
    1925                 1930                 1935             


Arg Val  Ser Thr Asp Asp Trp  Pro Cys Asp Trp Val  Ala Leu Gly 
    1940                 1945                 1950             


Ala Cys  Gly Ser Ala Ser Asn  Ile Pro Ile Pro Pro  Pro Cys Leu 
    1955                 1960                 1965             


Thr Pro  Ser Pro Glu Arg Gly  Ser Pro Gln Leu Asp  Cys Gly Pro 
    1970                 1975                 1980             


Pro Ala  Leu Gln Glu Met Pro  Ile Asn Gln Gly Gly  Glu Gly Lys 
    1985                 1990                 1995             


Lys 
    


<210>  44
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Val Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp 
                885                 890                 895     


Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940             


<210>  45
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Leu Arg Ala Pro Pro Pro Pro Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Leu Leu Pro Leu Leu Pro Ala Pro Gly Ala Ala Ala Ala Pro 
        35                  40                  45              


Ala Pro Arg Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val 
    50                  55                  60                  


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp 
65                  70                  75                  80  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
                85                  90                  95      


Ser Phe Ser Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
            100                 105                 110         


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
        115                 120                 125             


Asn Val Leu Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly 
    130                 135                 140                 


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
145                 150                 155                 160 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
                165                 170                 175     


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
            180                 185                 190         


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
        195                 200                 205             


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
    210                 215                 220                 


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
225                 230                 235                 240 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
                245                 250                 255     


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
            260                 265                 270         


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
        275                 280                 285             


Pro Asn Asn Ala Thr Pro Ile Thr Ser Tyr Pro Thr Leu Arg Ile Glu 
    290                 295                 300                 


Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys Gly Lys Val 
305                 310                 315                 320 


Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys Asp Val Leu 
                325                 330                 335     


Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu Ile Asp Glu 
            340                 345                 350         


Lys Asp Pro Asn Lys Glu Lys Gln Ala Phe Val Lys Thr Val Lys Asp 
        355                 360                 365             


Gln Ala Ser Glu Ile Gln Val Thr Met Met Leu Thr Glu Ser Cys Lys 
    370                 375                 380                 


Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr His Val Cys 
385                 390                 395                 400 


Ile Glu Glu Gly Glu Lys Pro Met Val Ile Leu Pro Tyr Met Asn Trp 
                405                 410                 415     


Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val Glu Ala Asn 
            420                 425                 430         


Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met Ala Ile Gln 
        435                 440                 445             


Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val Ile His Lys 
    450                 455                 460                 


Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu Gln Val Lys 
465                 470                 475                 480 


Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met Asp Tyr His 
                485                 490                 495     


Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met Ala Leu Glu 
            500                 505                 510         


Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val Trp Ala Phe 
        515                 520                 525             


Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr Pro Tyr Val 
    530                 535                 540                 


Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp Gly Tyr Arg 
545                 550                 555                 560 


Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala Val Met Ala 
                565                 570                 575     


Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe Gln Gln Leu 
            580                 585                 590         


Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala Tyr Val 
        595                 600                 605         


<210>  46
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Leu Arg Asn Val Pro Phe Arg Ser Glu Val Leu Gly Trp Asp 
1               5                   10                  15      


Pro Asp Ser Leu Ala Asp Tyr Phe Lys Lys Leu Asn Tyr Lys Asp Cys 
            20                  25                  30          


Glu Lys Ala Val Lys Lys Tyr His Ile Asp Gly Ala Arg Phe Leu Asn 
        35                  40                  45              


Leu Thr Glu Asn Asp Ile Gln Lys Phe Pro Lys Leu Arg Val Pro Ile 
    50                  55                  60                  


Leu Ser Lys Leu Ser Gln Glu Ile Asn Lys Asn Glu Glu Arg Arg Ser 
65                  70                  75                  80  


Ile Phe Thr Arg Lys Pro Gln Val Pro Arg Phe Pro Glu Glu Thr Glu 
                85                  90                  95      


Ser His Glu Glu Asp Asn Gly Gly Trp Ser Ser Phe Glu Glu Asp Asp 
            100                 105                 110         


Tyr Glu Ser Pro Asn Asp Asp Gln Asp Gly Glu Asp Asp Gly Asp Tyr 
        115                 120                 125             


Glu Ser Pro Asn Glu Glu Glu Glu Ala Pro Val Glu Asp Asp Ala Asp 
    130                 135                 140                 


Tyr Glu Pro Pro Pro Ser Asn Asp Glu Glu Ala Leu Gln Asn Ser Ile 
145                 150                 155                 160 


Leu Pro Ala Lys Pro Phe Pro Asn Ser Asn Ser Met Tyr Ile Asp Arg 
                165                 170                 175     


Pro Pro Ser Gly Lys Thr Pro Gln Gln Pro Pro Val Pro Pro Gln Arg 
            180                 185                 190         


Pro Met Ala Ala Leu Pro Pro Pro Pro Ala Gly Arg Asn His Ser Pro 
        195                 200                 205             


Leu Pro Pro Pro Gln Thr Asn His Glu Glu Pro Ser Arg Ser Arg Asn 
    210                 215                 220                 


His Lys Thr Ala Lys Leu Pro Ala Pro Ser Ile Asp Arg Ser Thr Lys 
225                 230                 235                 240 


Pro Pro Leu Asp Arg Ser Leu Ala Pro Phe Asp Arg Glu Pro Phe Thr 
                245                 250                 255     


Leu Gly Lys Lys Pro Pro Phe Ser Asp Lys Pro Ser Ile Pro Ala Gly 
            260                 265                 270         


Arg Ser Leu Gly Glu His Leu Pro Lys Ile Gln Lys Pro Pro Leu Pro 
        275                 280                 285             


Pro Thr Thr Glu Arg His Glu Arg Ser Ser Pro Leu Pro Gly Lys Lys 
    290                 295                 300                 


Pro Pro Val Pro Lys His Gly Trp Gly Pro Asp Arg Arg Glu Asn Asp 
305                 310                 315                 320 


Glu Asp Asp Val His Gln Arg Pro Leu Pro Gln Pro Ala Leu Leu Pro 
                325                 330                 335     


Met Ser Ser Asn Thr Phe Pro Ser Arg Ser Thr Lys Pro Ser Pro Met 
            340                 345                 350         


Asn Pro Leu Pro Ser Ser His Met Pro Gly Ala Phe Ser Glu Ser Asn 
        355                 360                 365             


Ser Ser Phe Pro Gln Ser Ala Ser Leu Pro Pro Tyr Phe Ser Gln Gly 
    370                 375                 380                 


Pro Ser Asn Arg Pro Pro Ile Arg Ala Glu Gly Arg Asn Phe Pro Leu 
385                 390                 395                 400 


Pro Leu Pro Asn Lys Pro Arg Pro Pro Ser Pro Ala Glu Glu Glu Asn 
                405                 410                 415     


Ser Leu Asn Glu Glu Trp Tyr Val Ser Tyr Ile Thr Arg Pro Glu Ala 
            420                 425                 430         


Glu Ala Ala Leu Arg Lys Ile Asn Gln Asp Gly Thr Phe Leu Val Arg 
        435                 440                 445             


Asp Ser Ser Lys Lys Thr Thr Thr Asn Pro Tyr Val Leu Met Val Leu 
    450                 455                 460                 


Tyr Lys Asp Lys Val Tyr Asn Ile Gln Ile Arg Tyr Gln Lys Glu Ser 
465                 470                 475                 480 


Gln Val Tyr Leu Leu Gly Thr Gly Leu Arg Gly Lys Glu Asp Phe Leu 
                485                 490                 495     


Ser Val Ser Asp Ile Ile Asp Tyr Phe Arg Lys Met Pro Leu Leu Leu 
            500                 505                 510         


Ile Asp Gly Lys Asn Arg Gly Ser Arg Tyr Gln Cys Thr Leu Thr His 
        515                 520                 525             


Ala Ala Gly Tyr Pro 
    530             


<210>  47
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 
1               5                   10                  15      


Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 
            20                  25                  30          


Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 
        35                  40                  45              


Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 
    50                  55                  60                  


Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser Pro 
65                  70                  75                  80  


Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser Leu Pro Ser 
                85                  90                  95      


Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys His Thr Gly Pro Gly 
            100                 105                 110         


Ala Glu Gly His Ser Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu 
        115                 120                 125             


Ala Ser Thr Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 
    130                 135                 140                 


Gly Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 
145                 150                 155                 160 


Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 
                165                 170                 175     


Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu Gly 
            180                 185                 190         


Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg Glu Ala Thr 
        195                 200                 205             


Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg Trp Gly Asp Thr Pro 
    210                 215                 220                 


Pro Gly Arg Lys Pro Gly Ser Pro Val Trp Gly Glu Gly Ser Tyr Leu 
225                 230                 235                 240 


Ser Ser Tyr Pro Thr Cys Pro Ala Gln Ala Trp Cys Ser Arg Ser Arg 
                245                 250                 255     


Leu Arg Ala Pro Ser Ser Ser Leu Gly Ala Phe Phe Arg Gly Asp Leu 
            260                 265                 270         


Pro Pro Pro Leu Gln Ala Gly Ala Ala 
        275                 280     


<210>  48
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Leu Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro 
1               5                   10                  15      


Gln Asn Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser 
            20                  25                  30          


Tyr Ser Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly 
        35                  40                  45              


Gly Gly Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His 
    50                  55                  60                  


Gly Arg Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu 
65                  70                  75                  80  


His Ile Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala 
                85                  90                  95      


Val Glu Asp Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly 
            100                 105                 110         


Thr Lys Leu Ser Val Lys Pro Asn Ile 
        115                 120     


<210>  49
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  49

Pro Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Arg Val 
1               5                   10                  15      


Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp 
            20                  25                  30          


Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Lys Ser 
        35                  40                  45              


Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu 
    50                  55                  60                  


Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr 
65                  70                  75                  80  


Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe 
                85                  90                  95      


Tyr Ile Cys Ser Ala Ser Met Gln Ala Asn Thr Gly Glu Leu Phe Phe 
            100                 105                 110         


Gly Glu Gly Ser Arg Leu Thr Val Leu Glu Asp Leu 
        115                 120                 


<210>  50
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Gly Ile Ser Gly Cys Pro Phe Phe Leu Trp Gly Leu Leu Ala 
1               5                   10                  15      


Leu Leu Gly Leu Ala Leu Val Ile Ser Leu Ile Phe Asn Ile Ser His 
            20                  25                  30          


Tyr Val Glu Lys Gln Arg Gln Asp Lys Met Tyr Ser Tyr Ser Ser Asp 
        35                  40                  45              


His Thr Arg Val Asp Glu Tyr Tyr Ile Glu Asp Thr Pro Ile Tyr Gly 
    50                  55                  60                  


Asn Leu Asp Asp Met Ile Ser Glu Pro Met Asp Glu Asn Cys Tyr Glu 
65                  70                  75                  80  


Gln Met Lys Ala Arg Pro Glu Lys Ser Val Asn Lys Met Gln Glu Ala 
                85                  90                  95      


Thr Pro Ser Ala Gln Ala Thr Asn Glu Thr Gln Met Cys Tyr Ala Ser 
            100                 105                 110         


Leu Asp His Ser Val Lys Gly Lys Arg Arg Lys Pro Arg Lys Gln Asn 
        115                 120                 125             


Thr His Phe Ser Asp Lys Asp Gly Asp Glu Gln Leu His Ala Ile Asp 
    130                 135                 140                 


Ala Ser Val Ser Lys Thr Thr Leu Val Asp Ser Phe Ser Pro Glu Ser 
145                 150                 155                 160 


Gln Ala Val Glu Glu Asn Ile His Asp Asp Pro Ile Arg Leu Phe Gly 
                165                 170                 175     


Leu Ile Arg Ala Lys Arg Glu Pro Ile Asn 
            180                 185     


<210>  51
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Arg Leu Gly Pro Arg Trp Lys Gly Glu Ala Leu Glu Gln Ala Ile 
1               5                   10                  15      


Ile Ser Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His 
            20                  25                  30          


Glu Arg Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu 
        35                  40                  45              


Arg Lys Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg 
    50                  55                  60                  


Pro Arg Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys 
65                  70                  75                  80  


Thr Val Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys 
                85                  90                  95      


Ile Pro Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr 
            100                 105                 110         


Leu Lys Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys 
        115                 120                 125             


Pro Asn Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu 
    130                 135                 140                 


Pro Ala His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr 
145                 150                 155                 160 


Leu Asn Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro 
                165                 170                 175     


Asp Lys Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro 
            180                 185                 190         


Tyr Ser Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg 
        195                 200                 205             


Asp Asn Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly 
    210                 215                 220                 


Ser Val Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val 
225                 230                 235                 240 


Ala Ile Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu 
                245                 250                 255     


Met Met Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile 
            260                 265                 270         


Val Arg Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met 
        275                 280                 285             


Glu Met Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg 
    290                 295                 300                 


Glu Glu Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser 
305                 310                 315                 320 


Met Gly Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu 
                325                 330                 335     


Ala Ala Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser 
            340                 345                 350         


Asp Phe Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr 
        355                 360                 365             


Ala Arg Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys 
    370                 375                 380                 


Ile Asn Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly 
385                 390                 395                 400 


Val Thr Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys 
                405                 410                 415     


Met Lys Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met 
            420                 425                 430         


Glu Cys Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp 
        435                 440                 445             


Cys Trp Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu 
    450                 455                 460                 


Gln Arg Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly 
465                 470                 475                 480 


Pro Pro Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
                485                 490             


<210>  52
<211>  1203
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Asn Arg Ser Pro Pro Leu Arg Glu Leu Pro Pro Ser Tyr Thr Pro 
1               5                   10                  15      


Pro Ala Arg Thr Ala Ala Pro Gln Ile Leu Ala Gly Ser Leu Lys Ala 
            20                  25                  30          


Pro Leu Trp Leu Arg Ala Tyr Phe Gln Gly Leu Leu Phe Ser Leu Gly 
        35                  40                  45              


Cys Gly Ile Gln Arg His Cys Gly Lys Val Leu Phe Leu Gly Leu Leu 
    50                  55                  60                  


Ala Phe Gly Ala Leu Ala Leu Gly Leu Arg Met Ala Ile Ile Glu Thr 
65                  70                  75                  80  


Asn Leu Glu Gln Leu Trp Val Glu Val Gly Ser Arg Val Ser Gln Glu 
                85                  90                  95      


Leu His Tyr Thr Lys Glu Lys Leu Gly Glu Glu Ala Ala Tyr Thr Ser 
            100                 105                 110         


Gln Met Leu Ile Gln Thr Ala Leu Gln Glu Gly Glu Asn Ile Leu Thr 
        115                 120                 125             


Pro Glu Ala Leu Gly Leu His Leu Gln Ala Ala Leu Thr Ala Ser Lys 
    130                 135                 140                 


Val Gln Val Ser Leu Tyr Gly Lys Ser Trp Asp Leu Asn Lys Ile Cys 
145                 150                 155                 160 


Tyr Lys Ser Gly Val Pro Leu Ile Glu Asn Gly Met Ile Glu Arg Met 
                165                 170                 175     


Ile Glu Lys Leu Phe Pro Cys Val Ile Leu Thr Pro Leu Asp Cys Phe 
            180                 185                 190         


Trp Glu Gly Ala Lys Leu Gln Gly Gly Ser Ala Tyr Leu Pro Gly Arg 
        195                 200                 205             


Pro Asp Ile Gln Trp Thr Asn Leu Asp Pro Glu Gln Leu Leu Glu Glu 
    210                 215                 220                 


Leu Gly Pro Phe Ala Ser Leu Glu Gly Phe Arg Glu Leu Leu Asp Lys 
225                 230                 235                 240 


Ala Gln Val Gly Gln Ala Tyr Val Gly Arg Pro Cys Leu His Pro Asp 
                245                 250                 255     


Asp Leu His Cys Pro Pro Ser Ala Pro Asn His His Ser Arg Gln Ala 
            260                 265                 270         


Pro Asn Val Ala His Glu Leu Ser Gly Gly Cys His Gly Phe Ser His 
        275                 280                 285             


Lys Phe Met His Trp Gln Glu Glu Leu Leu Leu Gly Gly Met Ala Arg 
    290                 295                 300                 


Asp Pro Gln Gly Glu Leu Leu Arg Ala Glu Ala Leu Gln Ser Thr Phe 
305                 310                 315                 320 


Leu Leu Met Ser Pro Arg Gln Leu Tyr Glu His Phe Arg Gly Asp Tyr 
                325                 330                 335     


Gln Thr His Asp Ile Gly Trp Ser Glu Glu Gln Ala Ser Thr Val Leu 
            340                 345                 350         


Gln Ala Trp Gln Arg Arg Phe Val Gln Leu Ala Gln Glu Ala Leu Pro 
        355                 360                 365             


Glu Asn Ala Ser Gln Gln Ile His Ala Phe Ser Ser Thr Thr Leu Asp 
    370                 375                 380                 


Asp Ile Leu His Ala Phe Ser Glu Val Ser Ala Ala Arg Val Val Gly 
385                 390                 395                 400 


Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Val Thr Met Leu Arg Trp 
                405                 410                 415     


Asp Cys Ala Gln Ser Gln Gly Ser Val Gly Leu Ala Gly Val Leu Leu 
            420                 425                 430         


Val Ala Leu Ala Val Ala Ser Gly Leu Gly Leu Cys Ala Leu Leu Gly 
        435                 440                 445             


Ile Thr Phe Asn Ala Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu 
    450                 455                 460                 


Gly Ile Gly Val Asp Asp Val Phe Leu Leu Ala His Ala Phe Thr Glu 
465                 470                 475                 480 


Ala Leu Pro Gly Thr Pro Leu Gln Glu Arg Met Gly Glu Cys Leu Gln 
                485                 490                 495     


Arg Thr Gly Thr Ser Val Val Leu Thr Ser Ile Asn Asn Met Ala Ala 
            500                 505                 510         


Phe Leu Met Ala Ala Leu Val Pro Ile Pro Ala Leu Arg Ala Phe Ser 
        515                 520                 525             


Leu Gln Ala Ala Ile Val Val Gly Cys Thr Phe Val Ala Val Met Leu 
    530                 535                 540                 


Val Phe Pro Ala Ile Leu Ser Leu Asp Leu Arg Arg Arg His Cys Gln 
545                 550                 555                 560 


Arg Leu Asp Val Leu Cys Cys Phe Ser Ser Pro Cys Ser Ala Gln Val 
                565                 570                 575     


Ile Gln Ile Leu Pro Gln Glu Leu Gly Asp Gly Thr Val Pro Val Gly 
            580                 585                 590         


Ile Ala His Leu Thr Ala Thr Val Gln Ala Phe Thr His Cys Glu Ala 
        595                 600                 605             


Ser Ser Gln His Val Val Thr Ile Leu Pro Pro Gln Ala His Leu Val 
    610                 615                 620                 


Pro Pro Pro Ser Asp Pro Leu Gly Ser Glu Leu Phe Ser Pro Gly Gly 
625                 630                 635                 640 


Ser Thr Arg Asp Leu Leu Gly Gln Glu Glu Glu Thr Arg Gln Lys Ala 
                645                 650                 655     


Ala Cys Lys Ser Leu Pro Cys Ala Arg Trp Asn Leu Ala His Phe Ala 
            660                 665                 670         


Arg Tyr Gln Phe Ala Pro Leu Leu Leu Gln Ser His Ala Lys Ala Ile 
        675                 680                 685             


Val Leu Val Leu Phe Gly Ala Leu Leu Gly Leu Ser Leu Tyr Gly Ala 
    690                 695                 700                 


Thr Leu Val Gln Asp Gly Leu Ala Leu Thr Asp Val Val Pro Arg Gly 
705                 710                 715                 720 


Thr Lys Glu His Ala Phe Leu Ser Ala Gln Leu Arg Tyr Phe Ser Leu 
                725                 730                 735     


Tyr Glu Val Ala Leu Val Thr Gln Gly Gly Phe Asp Tyr Ala His Ser 
            740                 745                 750         


Arg Arg Ala Leu Phe Asp Leu His Gln Arg Phe Ser Ser Leu Lys Ala 
        755                 760                 765             


Val Leu Pro Pro Pro Ala Thr Gln Ala Pro Arg Thr Trp Leu His Tyr 
    770                 775                 780                 


Tyr Arg Ser Trp Leu Gln Gly Ile Gln Ala Ala Phe Asp Gln Asp Trp 
785                 790                 795                 800 


Ala Ser Gly Arg Ile Thr Arg His Ser Tyr Arg Asn Gly Ser Glu Asp 
                805                 810                 815     


Gly Ala Leu Ala Tyr Lys Leu Leu Ile Gln Thr Gly Asp Ala Gln Glu 
            820                 825                 830         


Pro Leu Asp Phe Gly Gln Leu Thr Thr Arg Lys Leu Val Glu Arg Glu 
        835                 840                 845             


Gly Leu Ile Pro Pro Glu Leu Phe Tyr Met Gly Leu Thr Val Trp Val 
    850                 855                 860                 


Ser Ser Asp Pro Leu Gly Leu Ala Ala Ser Gln Ala Asn Phe Tyr Pro 
865                 870                 875                 880 


Pro Pro Pro Glu Trp Leu His Asp Lys Tyr Asp Thr Thr Gly Glu Asn 
                885                 890                 895     


Leu Arg Ile Pro Pro Ala Gln Pro Leu Glu Phe Ala Gln Phe Pro Phe 
            900                 905                 910         


Leu Leu Arg Gly Leu Gln Lys Thr Ala Asp Phe Val Glu Ala Ile Glu 
        915                 920                 925             


Gly Ala Arg Ala Ala Cys Ala Glu Ala Gly Gln Ala Gly Val His Ala 
    930                 935                 940                 


Tyr Pro Ser Gly Ser Pro Phe Leu Phe Trp Glu Gln Tyr Leu Gly Leu 
945                 950                 955                 960 


Arg Arg Cys Phe Leu Leu Ala Val Cys Ile Leu Leu Val Cys Thr Phe 
                965                 970                 975     


Leu Val Cys Ala Leu Leu Leu Leu Asn Pro Trp Thr Ala Gly Leu Ile 
            980                 985                 990         


Val Leu Val Leu Ala Met Met Thr  Val Glu Leu Phe Gly  Ile Met Gly 
        995                 1000                 1005             


Phe Leu  Gly Ile Lys Leu Ser  Ala Ile Pro Val Val  Ile Leu Val 
    1010                 1015                 1020             


Ala Ser  Val Gly Ile Gly Val  Glu Phe Thr Val His  Val Ala Leu 
    1025                 1030                 1035             


Gly Phe  Leu Thr Thr Gln Gly  Ser Arg Asn Leu Arg  Ala Ala His 
    1040                 1045                 1050             


Ala Leu  Glu His Thr Phe Ala  Pro Val Thr Asp Gly  Ala Ile Ser 
    1055                 1060                 1065             


Thr Leu  Leu Gly Leu Leu Met  Leu Ala Gly Ser His  Phe Asp Phe 
    1070                 1075                 1080             


Ile Val  Arg Tyr Phe Phe Ala  Ala Leu Thr Val Leu  Thr Leu Leu 
    1085                 1090                 1095             


Gly Leu  Leu His Gly Leu Val  Leu Leu Pro Val Leu  Leu Ser Ile 
    1100                 1105                 1110             


Leu Gly  Pro Pro Pro Glu Val  Ile Gln Met Tyr Lys  Glu Ser Pro 
    1115                 1120                 1125             


Glu Ile  Leu Ser Pro Pro Ala  Pro Gln Gly Gly Gly  Leu Arg Trp 
    1130                 1135                 1140             


Gly Ala  Ser Ser Ser Leu Pro  Gln Ser Phe Ala Arg  Val Thr Thr 
    1145                 1150                 1155             


Ser Met  Thr Val Ala Ile His  Pro Pro Pro Leu Pro  Gly Ala Tyr 
    1160                 1165                 1170             


Ile His  Pro Ala Pro Asp Glu  Pro Pro Trp Ser Pro  Ala Ala Thr 
    1175                 1180                 1185             


Ser Ser  Gly Asn Leu Ser Ser  Arg Gly Pro Gly Pro  Ala Thr Gly 
    1190                 1195                 1200             


<210>  53
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro Gln Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  54
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Gly Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  55
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Trp Trp Arg Val Leu Ser Leu Leu Ala Trp Phe Pro Leu Gln Glu 
1               5                   10                  15      


Ala Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu Gly Gln 
            20                  25                  30          


Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Asn Ser Ser Leu 
        35                  40                  45              


Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu Tyr Pro 
    50                  55                  60                  


Val Leu Lys Asn Ser Lys Tyr Gln Leu Leu His His Ser Ala Asn Gln 
65                  70                  75                  80  


Leu Ser Ile Thr Val Pro Asn Val Thr Leu Gln Asp Glu Gly Val Tyr 
                85                  90                  95      


Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val Lys Val 
            100                 105                 110         


Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser Val Ile 
        115                 120                 125             


Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser Thr Met 
    130                 135                 140                 


Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn Ser Met 
145                 150                 155                 160 


Glu Val Ser Gly Gly Thr Leu His Glu Phe Glu Thr Asp Gly Lys Lys 
                165                 170                 175     


Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys Asn Ser 
            180                 185                 190         


Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg Lys Leu 
        195                 200                 205             


Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu Thr Ala 
    210                 215                 220                 


Ser Asp Ala Leu Glu Arg Asn Ser Leu Ser Ser Gln Asp Pro Gln Gln 
225                 230                 235                 240 


Pro Thr Ser Thr Val Ser Val Thr Glu Asp Ser Ser Thr Ser Glu Ile 
                245                 250                 255     


Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu Thr Thr 
            260                 265                 270         


Glu Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser Gly Ile 
        275                 280                 285             


Leu Leu Leu Thr Leu Val Ser Phe Leu Ile Phe Ile Leu Phe Ile Ile 
    290                 295                 300                 


Val Gln Leu Phe Ile Met Lys Leu Arg Lys Thr His Val Ile Trp Lys 
305                 310                 315                 320 


Lys Glu Asn Glu Val Ser Glu His Thr Leu Glu Ser Tyr Arg Ser Arg 
                325                 330                 335     


Ser Asn Asn Glu Glu Thr Ser Ser Glu Glu Lys Asn Gly Gln Ser Ser 
            340                 345                 350         


His Pro Met Arg Cys Met Asn Tyr Ile Thr Lys Leu Tyr Ser Glu Gly 
        355                 360                 365             


Lys Thr Lys Arg Lys Glu Asn Val Gln His Ser Lys Leu Glu Glu Lys 
    370                 375                 380                 


His Ile Gln Val Pro Glu Ser Ile Val 
385                 390             


<210>  56
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  56

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210>  57
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Lys Ser Val Lys Val Ser Glu Asn Phe Ser Cys Asn Ile Thr Leu 
1               5                   10                  15      


Met Cys Ser Val Lys Gly Ala Glu Lys Ser Val Leu Tyr Ser Trp Thr 
            20                  25                  30          


Pro Arg Glu Pro His Ala Ser Glu Ser Asn Gly Gly Ser Ile Leu Thr 
        35                  40                  45              


Val Ser Arg Thr Pro Cys Asp Pro Asp Leu Pro Tyr Ile Cys Thr Ala 
    50                  55                  60                  


Gln Asn Pro Val Ser Gln Arg Ser Ser Leu Pro Val His Val Gly Gln 
65                  70                  75                  80  


Phe Cys Thr Asp Pro Gly Ala Ser Arg Gly Gly Thr Thr Gly Glu Thr 
                85                  90                  95      


Val Val Gly Val Leu Gly Glu Pro Val Thr Leu Pro Leu Ala Leu Pro 
            100                 105                 110         


Ala Cys Arg Asp Thr Glu Lys Val Val Trp Leu Phe Asn Thr Ser Ile 
        115                 120                 125             


Ile Ser Lys Glu Arg Glu Glu Ala Ala Thr Ala Asp Pro Leu Ile Lys 
    130                 135                 140                 


Ser Arg Asp Pro Tyr Lys Asn Arg Val Trp Val Ser Ser Gln Asp Cys 
145                 150                 155                 160 


Ser Leu Lys Ile Ser Gln Leu Lys Ile Glu Asp Ala Gly Pro Tyr His 
                165                 170                 175     


Ala Tyr Val Cys Ser Glu Ala Ser Ser Val Thr Ser Met Thr His Val 
            180                 185                 190         


Thr Leu Leu Ile Tyr Arg Pro Glu Arg Asn Thr Lys Leu Trp Ile Gly 
        195                 200                 205             


Leu Phe Leu Met Val Cys Leu Leu Cys Val Gly Ile Phe Ser Trp Cys 
    210                 215                 220                 


Ile Trp Lys Arg Lys Gly Arg Cys Ser Val Pro Ala Phe Cys Ser Ser 
225                 230                 235                 240 


Gln Ala Glu Ala Pro Ala Asp Thr Pro Glu Pro Thr Ala Gly His Thr 
                245                 250                 255     


Leu Tyr Ser Val Leu Ser Gln Gly Tyr Glu Lys Leu Asp Thr Pro Leu 
            260                 265                 270         


Arg Pro Ala Arg Gln Gln Pro Thr Pro Thr Ser Asp Ser Ser Ser Asp 
        275                 280                 285             


Ser Asn Leu Thr Thr Glu Glu Asp Glu Asp Arg Pro Glu Val His Lys 
    290                 295                 300                 


Pro Ile Ser Gly Arg Tyr Glu Val Phe Asp Gln Val Thr Gln Glu Gly 
305                 310                 315                 320 


Ala Gly His Asp Pro Ala Pro Glu Gly Gln Ala Asp Tyr Asp Pro Val 
                325                 330                 335     


Thr Pro Tyr Val Thr Glu Val Glu Ser Val Val Gly Glu Asn Thr Val 
            340                 345                 350         


Tyr Ala Gln Val Phe Asn Leu Gln Gly Lys Thr Pro Val Ser Gln Lys 
        355                 360                 365             


Glu Glu Ser Ser Ala Thr Ile Tyr Cys Ser Ile Arg Lys Pro Gln Val 
    370                 375                 380                 


Val Pro Pro Pro Gln Gln Asn Asp Leu Glu Ile Pro Glu Ser Pro Thr 
385                 390                 395                 400 


Tyr Glu Asn Phe Thr 
                405 


<210>  58
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Arg Ile 
                245                 250                 255     


Phe Pro Glu Gly Lys Met Trp Lys Leu Thr Phe Ser Pro Pro Gly Thr 
            260                 265                 270         


Glu Ala Ile Tyr Pro Arg Phe Ser 
        275                 280 


<210>  59
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu 
        115                 120                 125             


Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr 
    130                 135                 140                 


Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val 
145                 150                 155                 160 


Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn 
                165                 170                 175     


Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr 
            180                 185                 190         


Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro 
        195                 200                 205             


Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser 
    210                 215                 220                 


Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu 
                245                 250                 255     


Glu Asn Asn Pro Lys Gly Arg Ser Ser Lys Tyr Gly Leu Leu His Cys 
            260                 265                 270         


Gly Asn Thr Glu Lys Asp Gly Lys Ser Pro Leu Thr Ala His Asp Ala 
        275                 280                 285             


Arg His Thr Lys Ala Ile Cys Leu 
    290                 295     


<210>  60
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Val Met Arg Pro Leu Trp Ser Leu Leu Leu Trp Glu Ala Leu Leu 
1               5                   10                  15      


Pro Ile Thr Val Thr Gly Ala Gln Val Leu Ser Lys Val Gly Gly Ser 
            20                  25                  30          


Val Leu Leu Val Ala Ala Arg Pro Pro Gly Phe Gln Val Arg Glu Ala 
        35                  40                  45              


Ile Trp Arg Ser Leu Trp Pro Ser Glu Glu Leu Leu Ala Thr Phe Phe 
    50                  55                  60                  


Arg Gly Ser Leu Glu Thr Leu Tyr His Ser Arg Phe Leu Gly Arg Ala 
65                  70                  75                  80  


Gln Leu His Ser Asn Leu Ser Leu Glu Leu Gly Pro Leu Glu Ser Gly 
                85                  90                  95      


Asp Ser Gly Asn Phe Ser Val Leu Met Val Asp Thr Arg Gly Gln Pro 
            100                 105                 110         


Trp Thr Gln Thr Leu Gln Leu Lys Val Tyr Asp Ala Val Pro Arg Pro 
        115                 120                 125             


Val Val Gln Val Phe Ile Ala Val Glu Arg Asp Ala Gln Pro Ser Lys 
    130                 135                 140                 


Thr Cys Gln Val Phe Leu Ser Cys Trp Ala Pro Asn Ile Ser Glu Ile 
145                 150                 155                 160 


Thr Tyr Ser Trp Arg Arg Glu Thr Thr Met Asp Phe Gly Met Glu Pro 
                165                 170                 175     


His Ser Leu Phe Thr Asp Gly Gln Val Leu Ser Ile Ser Leu Gly Pro 
            180                 185                 190         


Gly Asp Arg Asp Val Ala Tyr Ser Cys Ile Val Ser Asn Pro Val Ser 
        195                 200                 205             


Trp Asp Leu Ala Thr Val Thr Pro Trp Asp Ser Cys His His Glu Ala 
    210                 215                 220                 


Ala Pro Gly Lys Ala Ser Tyr Lys Asp Val Leu Leu Val Val Val Pro 
225                 230                 235                 240 


Val Ser Leu Leu Leu Met Leu Val Thr Leu Phe Ser Ala Trp His Trp 
                245                 250                 255     


Cys Pro Cys Ser Gly Lys Lys Lys Lys Asp Val His Ala Asp Arg Val 
            260                 265                 270         


Gly Pro Glu Thr Glu Asn Pro Leu Val Gln Asp Leu Pro 
        275                 280                 285 


<210>  61
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  61

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210>  62
<211>  206
<212>  PRT
<213>  Mus musculus

<400>  62

Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu 
1               5                   10                  15      


Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile 
            20                  25                  30          


Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu 
        35                  40                  45              


Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His 
    50                  55                  60                  


Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr 
65                  70                  75                  80  


Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr 
                85                  90                  95      


Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His 
            100                 105                 110         


Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val 
        115                 120                 125             


Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser 
    130                 135                 140                 


Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu 
145                 150                 155                 160 


Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly 
                165                 170                 175     


Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr 
            180                 185                 190         


Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu 
        195                 200                 205     


<210>  63
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  63

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  64
<211>  444
<212>  DNA
<213>  Mus musculus

<400>  64
agctctagcc ctgctaaaga cccacctatc cagcggctca ggggagcagt aacacgctgt       60

gaagacggtc agttgtttat tagttcttac aagaacgagt accagacaat ggaagttcaa      120

aataattctg tcgtcatcaa atgtgacggg ttgtatataa tatatctgaa aggcagtttt      180

tttcaagagg taaagatcga cctgcacttt cgagaggatc ataatccaat ttctatacct      240

atgctcaatg atgggaggcg catcgtcttc accgtagtgg ccagcctcgc ttttaaggac      300

aaagtttatc tcactgttaa tgcacccgat acactgtgcg agcacctgca aattaacgat      360

ggagagctta tagttgtgca acttactcct ggatattgcg ctcccgaagg gtcttatcat      420

agtactgtaa accaagtacc cctt                                             444


<210>  65
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  65

His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp 
1               5                   10                  15      


Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser 
            20                  25                  30          


Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe 
        35                  40                  45              


Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser 
    50                  55                  60                  


Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
65                  70                  75                  80  


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
                85                  90                  95      


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
            100                 105                 110         


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
        115                 120                 125             


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
    130                 135                 140                 


Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
145                 150                 155                 160 


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
                165                 170                 175     


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
            180                 185                 190         


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
        195                 200                 205             


Ser Phe Gly Leu Leu Lys Leu 
    210                 215 


<210>  66
<211>  642
<212>  DNA
<213>  Mus musculus

<400>  66
cataggcgcc tggacaaggt cgaagaggag gtcaacctgc acgaggactt tgtctttatc       60

aagaagttga agcggtgcaa caagggcgaa ggatctctga gcctcctgaa ctgtgaagaa      120

atgcgccgac agtttgagga tctggtaaaa gacataacgc ttaacaagga agaaaagaag      180

gagaattctt tcgagatgca acgcggcgat gaggatccac agatcgccgc gcacgtcgtc      240

tcagaggcca attcaaacgc agcctcagta cttcaatggg cgaaaaaggg gtattacacc      300

atgaagtcta atcttgttat gctagagaat gggaagcagc tgacagtgaa gcgcgagggg      360

ctgtactatg tatatacaca agttaccttc tgcagcaata gggagccaag tagccagcgc      420

ccctttatcg tggggctgtg gctcaaaccc agcagcggct ccgaacgtat tctgcttaag      480

gctgccaaca ctcacagttc aagccagctg tgcgagcagc agtccgtaca tcttggcgga      540

gtctttgagc tccaggctgg cgcctcagtg ttcgtgaacg ttaccgaagc ttctcaggtt      600

attcaccggg tgggcttttc ttcctttgga ctgctgaaac tc                         642


<210>  67
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  67

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Ile 
                


<210>  68
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  68

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala 
            180                 185     


<210>  69
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  69

Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr Trp Ala Gln 
1               5                   10                  15      


Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe Leu Val Lys 
            20                  25                  30          


Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro Cys Ile Pro 
        35                  40                  45              


Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His Cys Glu Ser 
    50                  55                  60                  


Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys Thr Ile Thr 
65                  70                  75                  80  


Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys Arg Asp Lys 
                85                  90                  95      


Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu Thr Ala Arg 
            100                 105                 110         


Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His Leu Pro Tyr 
        115                 120                 125             


Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met Gln Thr Leu 
    130                 135                 140                 


Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr His Trp Pro 
145                 150                 155                 160 


Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg 
                165                 170         


<210>  70
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  70

Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn Pro Ser 
1               5                   10                  15      


His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys Pro Met 
            20                  25                  30          


Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp Cys Arg 
        35                  40                  45              


Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg Cys Thr 
    50                  55                  60                  


Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro Cys 
65                  70                  75                  80  


Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met Phe Cys 
                85                  90                  95      


Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His Ser Val 
            100                 105                 110         


Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln Lys Asn 
        115                 120                 125             


Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys Ala Ser 
    130                 135                 140                 


Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln Ala Lys 
145                 150                 155                 160 


Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met Pro Val 
                165                 170                 175     


Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu Thr Arg 
            180                 185                 190         


Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp Pro Gly 
        195                 200                 205             


Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys Arg Lys 
    210                 215                 220                 


Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys Thr Ala 
225                 230                 235                 240 


Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro Cys Ala 
                245                 250                 255     


Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile Cys Ala 
            260                 265                 270         


Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro Ile Cys 
        275                 280                 285             


Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys Asp Thr 
    290                 295                 300                 


Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr 
305                 310                 315                 320 


Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu 
                325                 330                 335     


Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala 
            340                 345                 350         


Pro Val Ala Leu Ser Ser Thr Gly Lys 
        355                 360     


<210>  71
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  71

Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu Ile Asn Ser Gln 
1               5                   10                  15      


Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val Ser Asp Cys Thr 
            20                  25                  30          


Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu Ser Glu Phe Leu 
        35                  40                  45              


Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His Lys Tyr Cys Asp 
    50                  55                  60                  


Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr Ser Glu Thr Asp 
65                  70                  75                  80  


Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr Ser Glu Ala Cys 
                85                  90                  95      


Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly Phe Gly Val Lys 
            100                 105                 110         


Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu Pro Cys Pro Val 
        115                 120                 125             


Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys Cys His Pro Trp 
    130                 135                 140                 


Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln Ala Gly Thr Asn 
145                 150                 155                 160 


Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu Arg 
                165                 170             


<210>  72
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  72

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro 
145                 150                 155             


<210>  73
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  73

Leu Gln Leu His Trp Arg Leu Gly Glu Met Val Thr Arg Leu Pro Asp 
1               5                   10                  15      


Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His 
            20                  25                  30          


Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
        35                  40                  45              


Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
    50                  55                  60                  


Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
65                  70                  75                  80  


Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
                85                  90                  95      


Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
            100                 105                 110         


Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
        115                 120                 125             


Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
    130                 135                 140                 


Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val Val Val Arg 
145                 150                 155                 160 


Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
                165                 170                 175     


Phe Gly Ala Phe Met Val 
            180         


<210>  74
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  74

Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro Val Gly Ser Glu Cys Cys 
1               5                   10                  15      


Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys Glu Ala Cys Gly Glu Leu 
            20                  25                  30          


Thr Gly Thr Val Cys Glu Pro Cys Pro Pro Gly Thr Tyr Ile Ala His 
        35                  40                  45              


Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys Gln Met Cys Asp Pro Ala 
    50                  55                  60                  


Met Gly Leu Arg Ala Ser Arg Asn Cys Ser Arg Thr Glu Asn Ala Val 
65                  70                  75                  80  


Cys Gly Cys Ser Pro Gly His Phe Cys Ile Val Gln Asp Gly Asp His 
                85                  90                  95      


Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser Ser Pro Gly Gln Arg Val 
            100                 105                 110         


Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr Leu Cys Gln Asn Cys Pro 
        115                 120                 125             


Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu Glu Glu Cys Gln His Gln 
    130                 135                 140                 


Thr Lys Cys Ser Trp Leu Val Thr Lys Ala Gly Ala Gly Thr Ser Ser 
145                 150                 155                 160 


Ser His Trp Val 
                


<210>  75
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  75

Gln Gly Gly Thr Arg Ser Pro Arg Cys Asp Cys Ala Gly Asp Phe His 
1               5                   10                  15      


Lys Lys Ile Gly Leu Phe Cys Cys Arg Gly Cys Pro Ala Gly His Tyr 
            20                  25                  30          


Leu Lys Ala Pro Cys Thr Glu Pro Cys Gly Asn Ser Thr Cys Leu Val 
        35                  40                  45              


Cys Pro Gln Asp Thr Phe Leu Ala Trp Glu Asn His His Asn Ser Glu 
    50                  55                  60                  


Cys Ala Arg Cys Gln Ala Cys Asp Glu Gln Ala Ser Gln Val Ala Leu 
65                  70                  75                  80  


Glu Asn Cys Ser Ala Val Ala Asp Thr Arg Cys Gly Cys Lys Pro Gly 
                85                  90                  95      


Trp Phe Val Glu Cys Gln Val Ser Gln Cys Val Ser Ser Ser Pro Phe 
            100                 105                 110         


Tyr Cys Gln Pro Cys Leu Asp Cys Gly Ala Leu His Arg His Thr Arg 
        115                 120                 125             


Leu Leu Cys Ser Arg Arg Asp Thr Asp Cys Gly Thr Cys Leu Pro Gly 
    130                 135                 140                 


Phe Tyr Glu His Gly Asp Gly Cys Val Ser Cys Pro Thr Ser Thr Leu 
145                 150                 155                 160 


Gly Ser Cys Pro Glu Arg Cys Ala Ala Val Cys Gly Trp Arg Gln 
                165                 170                 175 


<210>  76
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  76

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp 
            100                 


<210>  77
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  77

Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys 
1               5                   10                  15      


Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser 
            20                  25                  30          


Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly 
        35                  40                  45              


Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr 
    50                  55                  60                  


Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro 
65                  70                  75                  80  


Ala Thr Val Ala 
                


<210>  78
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Ser Phe Gly Leu Leu Asp Pro Lys 
1               5                   


<210>  79
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  79

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  80
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  80

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro 
    130                 


<210>  81
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  81

Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
1               5                   10                  15      


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
            20                  25                  30          


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
        35                  40                  45              


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
    50                  55                  60                  


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
65                  70                  75                  80  


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
                85                  90                  95      


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg 
            100                 105                 110     


<210>  82
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  82

Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser 
1               5                   10                  15      


Arg Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr 
            20                  25                  30          


Val Lys Met His Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp 
        35                  40                  45              


Leu Trp Lys Gln Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu 
    50                  55                  60                  


Lys Gly Arg Met Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Ile Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln 
                85                  90                  95      


Lys Cys Asn Asn Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu 
            100                 105                 110         


Arg Val Met Gly Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr 
        115                 120                 125             


Leu Lys Asp 
    130     


<210>  83
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  83

Ala Ser Tyr Gly Thr Gly Gly Arg Met Met Asn Cys Pro Lys Ile Leu 
1               5                   10                  15      


Arg Gln Leu Gly Ser Lys Val Leu Leu Pro Leu Thr Tyr Glu Arg Ile 
            20                  25                  30          


Asn Lys Ser Met Asn Lys Ser Ile His Ile Val Val Thr Met Ala Lys 
        35                  40                  45              


Ser Leu Glu Asn Ser Val Glu Asn Lys Ile Val Ser Leu Asp Pro Ser 
    50                  55                  60                  


Glu Ala Gly Pro Pro Arg Tyr Leu Gly Asp Arg Tyr Lys Phe Tyr Leu 
65                  70                  75                  80  


Glu Asn Leu Thr Leu Gly Ile Arg Glu Ser Arg Lys Glu Asp Glu Gly 
                85                  90                  95      


Trp Tyr Leu Met Thr Leu Glu Lys Asn Val Ser Val Gln Arg Phe Cys 
            100                 105                 110         


Leu Gln Leu Arg Leu Tyr Glu Gln Val Ser Thr Pro Glu Ile Lys Val 
        115                 120                 125             


Leu Asn Lys Thr Gln Glu Asn Gly Thr Cys Thr Leu Ile Leu Gly Cys 
    130                 135                 140                 


Thr Val Glu Lys Gly Asp His Val Ala Tyr Ser Trp Ser Glu Lys Ala 
145                 150                 155                 160 


Gly Thr His Pro Leu Asn Pro Ala Asn Ser Ser His Leu Leu Ser Leu 
                165                 170                 175     


Thr Leu Gly Pro Gln His Ala Asp Asn Ile Tyr Ile Cys Thr Val Ser 
            180                 185                 190         


Asn Pro Ile Ser Asn Asn Ser Gln Thr Phe Ser Pro Trp Pro Gly Cys 
        195                 200                 205             


Arg Thr Asp Pro Ser Glu Thr Lys Pro 
    210                 215         


<210>  84
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  84

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu Cys Cys Gln Leu Lys 
        115                 120 


<210>  85
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  85

Gln Arg Pro Thr Gly Gly Pro Gly Cys Gly Pro Gly Arg Leu Leu Leu 
1               5                   10                  15      


Gly Thr Gly Thr Asp Ala Arg Cys Cys Arg Val His Thr Thr Arg Cys 
            20                  25                  30          


Cys Arg Asp Tyr Pro Gly Glu Glu Cys Cys Ser Glu Trp Asp Cys Met 
        35                  40                  45              


Cys Val Gln Pro Glu Phe His Cys Gly Asp Pro Cys Cys Thr Thr Cys 
    50                  55                  60                  


Arg His His Pro Cys Pro Pro Gly Gln Gly Val Gln Ser Gln Gly Lys 
65                  70                  75                  80  


Phe Ser Phe Gly Phe Gln Cys Ile Asp Cys Ala Ser Gly Thr Phe Ser 
                85                  90                  95      


Gly Gly His Glu Gly His Cys Lys Pro Trp Thr Asp Cys Thr Gln Phe 
            100                 105                 110         


Gly Phe Leu Thr Val Phe Pro Gly Asn Lys Thr His Asn Ala Val Cys 
        115                 120                 125             


Val Pro Gly Ser Pro Pro Ala Glu Pro 
    130                 135         


<210>  86
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  86

Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr 
1               5                   10                  15      


Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
            20                  25                  


<210>  87
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Ala Gln Ala Gln Ser Asp Cys Ser Cys Ser Thr Val Ser Pro 
1               5                   10                  15  


<210>  88
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro 
            20                  25              


<210>  89
<211>  81
<212>  PRT
<213>  Mus musculus

<400>  89

Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His Pro 
1               5                   10                  15      


Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr Gly 
            20                  25                  30          


Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr Asn 
        35                  40                  45              


Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg Asp 
    50                  55                  60                  


Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His Pro 
65                  70                  75                  80  


Lys 
    


<210>  90
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys 
            20              


<210>  91
<211>  81
<212>  DNA
<213>  Mus musculus

<400>  91
gagggtgaag gagtgcagcc tctcgacgag aacctcgaaa atggcagtag gccccggttc       60

aaatggaaga agacactgcg g                                                 81


<210>  92
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys 
            20          


<210>  93
<211>  63
<212>  DNA
<213>  Mus musculus

<400>  93
atagagactt attcccagcc cagccctaga agtgttgcaa ccgggctccc agcctctatg       60

aag                                                                     63


<210>  94
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  94

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  95
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  95

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  96
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  96

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  97
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  97

Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu 
1               5                   10                  15      


Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser 
            20                  25                  30          


Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr 
        35                  40                  45              


Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu 
    50                  55                  60                  


Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln 
65                  70                  75                  80  


Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu 
                85                  90                  95      


Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr 
            100                 105                 110         


Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu 
        115                 120                 125             


Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu 
    130                 135                 140                 


Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu 
145                 150                 155                 160 


Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu 
                165                 170                 175     


Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185                 


<210>  98
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  98

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  99
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  99

His Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val 
1               5                   10                  15      


Pro Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
            20                  25                  30  


<210>  100
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg 
        35          


<210>  101
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  101

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  102
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  102

Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala 
1               5                   10                  15      


Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu 
            20                  25                  30          


Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser 
        35                  40                  45              


Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly 
    50                  55                  60                  


Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp 
65                  70                  75                  80  


Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu 
                85                  90                  95      


Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly 
            100                 105                 110         


Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys 
        115                 120                 125             


Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val 
    130                 135                 140                 


Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys 
145                 150                 155                 160 


Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala 
                165                 170                 175     


Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg 
            180                 185                 190         


Leu Gln Arg Gly Pro 
        195         


<210>  103
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  103

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile 
    50                  55  


<210>  104
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  104

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        35                  40                  45  


<210>  105
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  105

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  106
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  106

Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
1               5                   10              


<210>  107
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  107

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  108
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  108

Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu 
1               5                   10                  15      


Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser 
            20                  25                  30          


Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val 
        35                  40                  45              


Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
    50                  55                  60      


<210>  109
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  109

Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr 
1               5                   10                  15      


Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr 
            20                  25                  30          


Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln 
        35                  40                  45              


Glu 
    


<210>  110
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  110

Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr Val Glu 
1               5                   10                  15      


Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly Pro Leu 
            20                  25                  30          


Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr Thr Ile 
        35                  40                  45              


Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu Thr Asn 
    50                  55                  60                  


Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 
65                  70                  75          


<210>  111
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  111

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  112
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  112

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  113
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  113

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  114
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  114

Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210>  115
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  115

Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Cys Ala Val Phe Leu 
            20      


<210>  116
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  116

Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala Ala Cys 
1               5                   10                  15      


Val Pro Ile Phe Thr 
            20      


<210>  117
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  117

Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys 
1               5                   10                  15      


Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu 
            20                  25          


<210>  118
<211>  66
<212>  DNA
<213>  Mus musculus

<400>  118
ctggtagtgt ctggaataaa aggtgcaggt atgttgctgt gcttcatcta tgtttgcctt       60

caattg                                                                  66


<210>  119
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  119

Ile Phe Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly 
1               5                   10                  15      


Ser Ala Leu Phe Ala Val Tyr Leu 
            20                  


<210>  120
<211>  72
<212>  DNA
<213>  Mus musculus

<400>  120
attttcatgt atctgctgac cgtctttctc atcactcaga tgattgggag tgtcctgttc       60

gcggtctatc tg                                                           72


<210>  121
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  121

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  122
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  122

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210>  123
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  123

Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210>  124
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  124

Pro Val Leu Asp Ala Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu 
1               5                   10                  15      


Val Val Val Val Gly Ser Ser Ala Phe Leu Leu 
            20                  25          


<210>  125
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  125

Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile Leu 
1               5                   10                  15      


Leu Val Leu Val Phe Ile 
            20          


<210>  126
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  126

Pro Leu Leu Leu Leu Leu Leu Leu Pro Val Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Trp Cys Leu 
            20      


<210>  127
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  127

Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly Ala Gly Leu Ala Val 
1               5                   10                  15      


Gln Gly Trp Phe Leu 
            20      


<210>  128
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  128

Trp Trp Phe Leu Ser Gly Ser Leu Val Ile Val Ile Val Cys Ser Thr 
1               5                   10                  15      


Val Gly Leu Ile Ile 
            20      


<210>  129
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Phe Trp Val Gln Val Leu Leu Ala Gly Leu Val Val Pro Leu Leu 
1               5                   10                  15      


Leu Gly Ala Thr Leu 
            20      


<210>  130
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  130

Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  131
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  131

Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Val Phe Cys Phe Ala 
            20      


<210>  132
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  132

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  133
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  133

Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
1               5                   10                  15      


Ser Gly Leu 
            


<210>  134
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  134

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  135
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  135

Ile Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro 
1               5                   10                  15      


Gly Thr Leu Leu Leu Phe 
            20          


<210>  136
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  136

Gly Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val 
1               5                   10                  15      


Pro Ile Phe Leu Leu 
            20      


<210>  137
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  137

Trp Ala Val Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile 
1               5                   10                  15      


Met Val Val Ile Leu 
            20      


<210>  138
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  138

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  139
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  139

Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys Val Leu 
1               5                   10                  15      


Leu Leu Thr Ser Ala 
            20      


<210>  140
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  140

Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
1               5                   10                  15      


Val Gly Ala Val Phe 
            20      


<210>  141
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  141

Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val 
            20      


<210>  142
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  142

Asn Ile Leu Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp 
1               5                   10                  15      


Gly Gln Phe Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp 
            20                  25                  30          


Glu Lys Thr Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile 
        35                  40                  45              


Val Ile Val Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys 
    50                  55                  60                  


Asn Ala Thr Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile 
65                  70                  75                  80  


Leu Leu His Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe 
                85                  90                  95      


Val Ile Ala Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val 
            100                 105                 110         


Val Gly Leu Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro 
        115                 120                 125             


Leu Leu Ile Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly 
    130                 135                 140                 


Leu Val Tyr Met 
145             


<210>  143
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated 41BBL

<400>  143

Met Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg 
            20                  25                  30          


Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
        35                  40                  45              


Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
    50                  55                  60                  


Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu 
65                  70                  75                  80  


Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 
                85                  90                  95      


Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
            100                 105                 110         


Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
        115                 120                 125             


Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 
    130                 135                 140                 


Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro 
145                 150                 155                 160 


Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 
                165                 170                 175     


Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu 
            180                 185                 190         


Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu 
        195                 200                 205             


Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
    210                 215                 220                 


Arg Ser Glu 
225         


<210>  144
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated murine 41BBL

<400>  144

Met Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala Ala 
1               5                   10                  15      


Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile 
            20                  25                  30          


Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val 
        35                  40                  45              


Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser 
    50                  55                  60                  


Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn 
65                  70                  75                  80  


Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu 
                85                  90                  95      


Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp 
            100                 105                 110         


Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr 
        115                 120                 125             


Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu 
    130                 135                 140                 


Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val 
145                 150                 155                 160 


Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp 
                165                 170                 175     


Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu 
            180                 185                 190         


Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu 
        195                 200                 205             


Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp 
    210                 215                 220                 


Asn Pro Trp Glu 
225             


<210>  145
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated OX40L

<400>  145

Met Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu 
1               5                   10                  15      


Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His 
            20                  25                  30          


Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys 
        35                  40                  45              


Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met 
    50                  55                  60                  


Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu 
65                  70                  75                  80  


Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His 
                85                  90                  95      


Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser 
            100                 105                 110         


Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr 
        115                 120                 125             


Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn 
    130                 135                 140                 


Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val 
145                 150                 155                 160 


Leu 
    


<210>  146
<211>  513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated murine  OX40L

<400>  146
atgctggtag tgtctggaat aaaaggtgca ggtatgttgc tgtgcttcat ctatgtttgc       60

cttcaattga gctctagccc tgctaaagac ccacctatcc agcggctcag gggagcagta      120

acacgctgtg aagacggtca gttgtttatt agttcttaca agaacgagta ccagacaatg      180

gaagttcaaa ataattctgt cgtcatcaaa tgtgacgggt tgtatataat atatctgaaa      240

ggcagttttt ttcaagaggt aaagatcgac ctgcactttc gagaggatca taatccaatt      300

tctataccta tgctcaatga tgggaggcgc atcgtcttca ccgtagtggc cagcctcgct      360

tttaaggaca aagtttatct cactgttaat gcacccgata cactgtgcga gcacctgcaa      420

attaacgatg gagagcttat agttgtgcaa cttactcctg gatattgcgc tcccgaaggg      480

tcttatcata gtactgtaaa ccaagtaccc ctt                                   513


<210>  147
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated CD40L

<400>  147

Met Ile Phe Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile 
1               5                   10                  15      


Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg Arg Leu Asp Lys Ile 
            20                  25                  30          


Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile 
        35                  40                  45              


Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu 
    50                  55                  60                  


Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn 
65                  70                  75                  80  


Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp 
                85                  90                  95      


Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys 
            100                 105                 110         


Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser 
        115                 120                 125             


Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg 
    130                 135                 140                 


Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg 
145                 150                 155                 160 


Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser 
                165                 170                 175     


Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser 
            180                 185                 190         


Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe 
        195                 200                 205             


Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser 
    210                 215                 220                 


Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
225                 230                 235                 240 


<210>  148
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated murine CD40L

<400>  148
atgattttca tgtatctgct gaccgtcttt ctcatcactc agatgattgg gagtgtcctg       60

ttcgcggtct atctgcatag gcgcctggac aaggtcgaag aggaggtcaa cctgcacgag      120

gactttgtct ttatcaagaa gttgaagcgg tgcaacaagg gcgaaggatc tctgagcctc      180

ctgaactgtg aagaaatgcg ccgacagttt gaggatctgg taaaagacat aacgcttaac      240

aaggaagaaa agaaggagaa ttctttcgag atgcaacgcg gcgatgagga tccacagatc      300

gccgcgcacg tcgtctcaga ggccaattca aacgcagcct cagtacttca atgggcgaaa      360

aaggggtatt acaccatgaa gtctaatctt gttatgctag agaatgggaa gcagctgaca      420

gtgaagcgcg aggggctgta ctatgtatat acacaagtta ccttctgcag caatagggag      480

ccaagtagcc agcgcccctt tatcgtgggg ctgtggctca aacccagcag cggctccgaa      540

cgtattctgc ttaaggctgc caacactcac agttcaagcc agctgtgcga gcagcagtcc      600

gtacatcttg gcggagtctt tgagctccag gctggcgcct cagtgttcgt gaacgttacc      660

gaagcttctc aggttattca ccgggtgggc ttttcttcct ttggactgct gaaactc         717


<210>  149
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated human FLT3L

<400>  149

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu 
        195                 200                 205 


<210>  150
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated human LIGHT

<400>  150

Met Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly Ala Gly Leu Ala 
1               5                   10                  15      


Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg Leu Gly Glu Met 
            20                  25                  30          


Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile 
        35                  40                  45              


Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly 
    50                  55                  60                  


Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
65                  70                  75                  80  


Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
                85                  90                  95      


Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
            100                 105                 110         


Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
        115                 120                 125             


Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
    130                 135                 140                 


Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
145                 150                 155                 160 


Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
                165                 170                 175     


Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
            180                 185                 190         


Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
        195                 200                 


<210>  151
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BBL-OX40 DCR

<400>  151

Met Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
1               5                   10                  15      


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
            20                  25                  30          


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Trp Ala Leu Val Ala 
        35                  40                  45              


Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
    50                  55                  60                  


Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
65                  70                  75                  80  


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
                85                  90                  95      


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
            100                 105                 110         


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
        115                 120                 125             


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
    130                 135                 140                 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
145                 150                 155                 160 


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                165                 170                 175     


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
            180                 185                 190         


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
        195                 200                 205             


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
    210                 215                 220                 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
225                 230                 235                 240 


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                245                 250                 255     


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            260                 265                 


<210>  152
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu41BBL-OX40 DCR

<400>  152

Met Arg Lys Ala Trp Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly 
1               5                   10                  15      


Asn Ser Phe Arg Thr Pro Ile Gln Glu Glu His Thr Asp Ala His Phe 
            20                  25                  30          


Thr Leu Ala Lys Ile Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu 
        35                  40                  45              


Leu Ile Ala Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro 
    50                  55                  60                  


Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn 
65                  70                  75                  80  


Ala Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr 
                85                  90                  95      


Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala 
            100                 105                 110         


Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly 
        115                 120                 125             


Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu 
    130                 135                 140                 


Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys 
145                 150                 155                 160 


Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val 
                165                 170                 175     


Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu 
            180                 185                 190         


Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val 
        195                 200                 205             


Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu 
    210                 215                 220                 


Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg 
225                 230                 235                 240 


Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu 
                245                 250                 255     


Val Lys Pro Asp Asn Pro Trp Glu 
            260                 


<210>  153
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BBL-CD27 DCR

<400>  153

Met Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
    50                  55                  60                  


Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg 
65                  70                  75                  80  


Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
                85                  90                  95      


Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
            100                 105                 110         


Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu 
        115                 120                 125             


Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 
    130                 135                 140                 


Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
145                 150                 155                 160 


Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                165                 170                 175     


Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 
            180                 185                 190         


Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro 
        195                 200                 205             


Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 
    210                 215                 220                 


Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu 
225                 230                 235                 240 


Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu 
                245                 250                 255     


Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
            260                 265                 270         


Arg Ser Glu 
        275 


<210>  154
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu41BBL-CD27 DCR

<400>  154

Met Gln Arg Arg Asn His Gly Pro Asn Glu Asp Arg Gln Ala Val Pro 
1               5                   10                  15      


Glu Glu Pro Cys Pro Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Ala 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Phe Tyr Pro 
        35                  40                  45              


Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala Ala Cys 
    50                  55                  60                  


Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr 
65                  70                  75                  80  


Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr 
                85                  90                  95      


Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro 
            100                 105                 110         


Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr 
        115                 120                 125             


Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser 
    130                 135                 140                 


Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser 
145                 150                 155                 160 


Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe 
                165                 170                 175     


Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln 
            180                 185                 190         


Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu 
        195                 200                 205             


Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser 
    210                 215                 220                 


Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg 
225                 230                 235                 240 


Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser 
                245                 250                 255     


Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn 
            260                 265                 270         


Pro Trp Glu 
        275 


<210>  155
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BBL-CD30 DCR

<400>  155

Met Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His 
1               5                   10                  15      


Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp 
            20                  25                  30          


Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val 
        35                  40                  45              


Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met 
    50                  55                  60                  


Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu 
65                  70                  75                  80  


Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro 
                85                  90                  95      


Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile 
            100                 105                 110         


Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu 
        115                 120                 125             


Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu 
    130                 135                 140                 


Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr 
145                 150                 155                 160 


Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu 
                165                 170                 175     


Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys Trp Ala 
            180                 185                 190         


Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala 
        195                 200                 205             


Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro 
    210                 215                 220                 


Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
225                 230                 235                 240 


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                245                 250                 255     


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
            260                 265                 270         


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
        275                 280                 285             


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
    290                 295                 300                 


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
305                 310                 315                 320 


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
                325                 330                 335     


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
            340                 345                 350         


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
        355                 360                 365             


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
    370                 375                 380                 


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
385                 390                 395                 400 


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                405                 410                 415     


<210>  156
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu41BBL-CD30 DCR

<400>  156

Met Tyr Trp Lys Ala Cys Arg Arg Arg Phe Gln Gln Lys Phe His Leu 
1               5                   10                  15      


Asp Tyr Leu Val Gln Thr Phe Gln Pro Lys Met Glu Gln Thr Asp Ser 
            20                  25                  30          


Cys Pro Thr Glu Lys Leu Thr Gln Pro Gln Arg Ser Gly Ser Val Thr 
        35                  40                  45              


Asp Pro Ser Thr Gly His Lys Leu Ser Pro Val Ser Pro Pro Pro Ala 
    50                  55                  60                  


Val Glu Thr Cys Ala Ser Val Gly Ala Thr Tyr Leu Glu Asn Leu Pro 
65                  70                  75                  80  


Leu Leu Asp Asp Ser Pro Ala Gly Asn Pro Phe Ser Pro Arg Glu Pro 
                85                  90                  95      


Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Arg Ile Glu Lys 
            100                 105                 110         


Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Ser Val Lys Thr 
        115                 120                 125             


Glu Val Pro Glu Gly Arg Ala Pro Ala Gly Ser Thr Glu Ser Glu Leu 
    130                 135                 140                 


Glu Ala Glu Leu Glu Val Asp His Ala Pro His Tyr Pro Glu Gln Glu 
145                 150                 155                 160 


Thr Glu Pro Pro Leu Gly Ser Cys Thr Glu Val Met Phe Ser Val Glu 
                165                 170                 175     


Glu Gly Gly Lys Glu Asp His Gly Pro Thr Thr Val Ser Glu Lys Leu 
            180                 185                 190         


Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala Ala Cys Val 
        195                 200                 205             


Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr 
    210                 215                 220                 


Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro 
225                 230                 235                 240 


Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val 
                245                 250                 255     


Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr 
            260                 265                 270         


Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln 
        275                 280                 285             


Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro 
    290                 295                 300                 


Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr 
305                 310                 315                 320 


Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala 
                325                 330                 335     


Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu 
            340                 345                 350         


Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln 
        355                 360                 365             


Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala 
    370                 375                 380                 


Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr 
385                 390                 395                 400 


Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro 
                405                 410                 415     


Trp Glu 
        


<210>  157
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BBL-CD40 DCR

<400>  157

Met Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
1               5                   10                  15      


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            20                  25                  30          


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        35                  40                  45              


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Trp 
    50                  55                  60                  


Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys 
65                  70                  75                  80  


Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser 
                85                  90                  95      


Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser 
            100                 105                 110         


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
        115                 120                 125             


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
    130                 135                 140                 


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
145                 150                 155                 160 


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
                165                 170                 175     


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
            180                 185                 190         


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
        195                 200                 205             


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
    210                 215                 220                 


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
225                 230                 235                 240 


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
                245                 250                 255     


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
            260                 265                 270         


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
        275                 280                 285             


Glu 
    


<210>  158
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu41BBL-CD40 DCR

<400>  158

Met Lys Lys Val Val Lys Lys Pro Lys Asp Asn Glu Ile Leu Pro Pro 
1               5                   10                  15      


Ala Ala Arg Arg Gln Asp Pro Gln Glu Met Glu Asp Tyr Pro Gly His 
            20                  25                  30          


Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val 
        35                  40                  45              


Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60                  


Val Thr Asp Ser Ile Ala Leu Arg Pro Leu Val Leu Tyr Gly Leu Val 
65                  70                  75                  80  


Ala Leu Val Leu Leu Leu Leu Ile Ala Ala Cys Val Pro Ile Phe Thr 
                85                  90                  95      


Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu 
            100                 105                 110         


Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile 
        115                 120                 125             


Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu 
    130                 135                 140                 


Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His 
145                 150                 155                 160 


Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr 
                165                 170                 175     


Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr 
            180                 185                 190         


Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His 
        195                 200                 205             


Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val 
    210                 215                 220                 


Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser 
225                 230                 235                 240 


Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu 
                245                 250                 255     


Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly 
            260                 265                 270         


Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr 
        275                 280                 285             


Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu 
    290                 295                 300         


<210>  159
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BBL-HVEM DCR

<400>  159

Met Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile 
1               5                   10                  15      


Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val 
            20                  25                  30          


Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu 
        35                  40                  45              


Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Trp Ala Leu 
    50                  55                  60                  


Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val 
65                  70                  75                  80  


Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly 
                85                  90                  95      


Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
            100                 105                 110         


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
        115                 120                 125             


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
    130                 135                 140                 


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
145                 150                 155                 160 


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
                165                 170                 175     


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
            180                 185                 190         


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
        195                 200                 205             


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
    210                 215                 220                 


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
225                 230                 235                 240 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                245                 250                 255     


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
            260                 265                 270         


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        275                 280                 285         


<210>  160
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu41BBL-HVEM DCR

<400>  160

Met Thr Arg Arg His Leu His Thr Ser Ser Val Ala Lys Glu Leu Glu 
1               5                   10                  15      


Pro Phe Gln Glu Gln Gln Glu Asn Thr Ile Arg Phe Pro Val Thr Glu 
            20                  25                  30          


Val Gly Phe Ala Glu Thr Glu Glu Glu Thr Ala Ser Asn Leu Tyr Gly 
        35                  40                  45              


Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala Ala Cys Val Pro Ile 
    50                  55                  60                  


Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro 
65                  70                  75                  80  


Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser 
                85                  90                  95      


His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala 
            100                 105                 110         


Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn 
        115                 120                 125             


Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu 
    130                 135                 140                 


Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu 
145                 150                 155                 160 


Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr 
                165                 170                 175     


Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro 
            180                 185                 190         


Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro 
        195                 200                 205             


Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu 
    210                 215                 220                 


Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu 
225                 230                 235                 240 


His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn 
                245                 250                 255     


Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu 
            260                 265                 270         


<210>  161
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BBL-DR3 DCR

<400>  161

Met Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr 
1               5                   10                  15      


Ala Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His 
            20                  25                  30          


Leu Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser 
        35                  40                  45              


Ser Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro 
    50                  55                  60                  


Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser 
65                  70                  75                  80  


Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr 
                85                  90                  95      


Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro 
            100                 105                 110         


Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp 
        115                 120                 125             


Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala 
    130                 135                 140                 


Val Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu 
145                 150                 155                 160 


Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala 
                165                 170                 175     


Ala Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser 
            180                 185                 190         


Arg Leu Gln Arg Gly Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu 
        195                 200                 205             


Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala 
    210                 215                 220                 


Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu 
225                 230                 235                 240 


Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
                245                 250                 255     


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            260                 265                 270         


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        275                 280                 285             


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    290                 295                 300                 


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
305                 310                 315                 320 


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                325                 330                 335     


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            340                 345                 350         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        355                 360                 365             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    370                 375                 380                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
385                 390                 395                 400 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                405                 410                 415     


Gly Leu Pro Ser Pro Arg Ser Glu 
            420                 


<210>  162
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu41BBL-DR3 DCR

<400>  162

Met Ile Cys Ala Tyr Cys Arg Trp Gln Pro Cys Lys Ala Val Val Thr 
1               5                   10                  15      


Ala Asp Thr Ala Gly Thr Glu Thr Leu Ala Ser Pro Gln Thr Ala His 
            20                  25                  30          


Leu Ser Ala Ser Asp Ser Ala His Thr Leu Leu Ala Pro Pro Ser Ser 
        35                  40                  45              


Thr Gly Lys Ile Cys Thr Thr Val Gln Leu Val Gly Asn Asn Trp Thr 
    50                  55                  60                  


Pro Gly Leu Ser Gln Thr Gln Glu Val Val Cys Gly Gln Ala Ser Gln 
65                  70                  75                  80  


Pro Trp Asp Gln Leu Pro Asn Arg Thr Leu Gly Thr Pro Leu Ala Ser 
                85                  90                  95      


Pro Leu Ser Pro Ala Pro Pro Ala Gly Ser Pro Ala Ala Val Leu Gln 
            100                 105                 110         


Pro Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg 
        115                 120                 125             


Trp Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu 
    130                 135                 140                 


Ala Val Glu Val Glu Ile Cys Arg Phe Arg Asp Gln Gln Tyr Glu Met 
145                 150                 155                 160 


Leu Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Ile Tyr 
                165                 170                 175     


Ala Ala Leu Glu Arg Met Gly Leu Glu Gly Cys Ala Glu Asp Leu Arg 
            180                 185                 190         


Ser Arg Leu Gln Arg Gly Pro Leu Tyr Gly Leu Val Ala Leu Val Leu 
        195                 200                 205             


Leu Leu Leu Ile Ala Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro 
    210                 215                 220                 


Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu 
225                 230                 235                 240 


Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro Asn 
                245                 250                 255     


Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn 
            260                 265                 270         


Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly 
        275                 280                 285             


Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys 
    290                 295                 300                 


Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu 
305                 310                 315                 320 


Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly 
                325                 330                 335     


Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp 
            340                 345                 350         


Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys 
        355                 360                 365             


Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His 
    370                 375                 380                 


Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala 
385                 390                 395                 400 


Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu 
                405                 410                 415     


Phe Leu Val Lys Pro Asp Asn Pro Trp Glu 
            420                 425     


<210>  163
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BBL-41BB DCR

<400>  163

Met Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Trp Ala Leu Val Ala 
        35                  40                  45              


Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
    50                  55                  60                  


Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
65                  70                  75                  80  


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
                85                  90                  95      


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
            100                 105                 110         


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
        115                 120                 125             


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
    130                 135                 140                 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
145                 150                 155                 160 


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                165                 170                 175     


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
            180                 185                 190         


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
        195                 200                 205             


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
    210                 215                 220                 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
225                 230                 235                 240 


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                245                 250                 255     


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            260                 265                 


<210>  164
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu41BBL-41BB DCR

<400>  164

Met Ser Val Leu Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys 
1               5                   10                  15      


Gln Pro Phe Lys Lys Thr Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg 
            20                  25                  30          


Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu Leu Tyr 
        35                  40                  45              


Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala Ala Cys Val Pro 
    50                  55                  60                  


Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser 
65                  70                  75                  80  


Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val 
                85                  90                  95      


Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe 
            100                 105                 110         


Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu 
        115                 120                 125             


Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly 
    130                 135                 140                 


Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly 
145                 150                 155                 160 


Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn 
                165                 170                 175     


Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys 
            180                 185                 190         


Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe 
        195                 200                 205             


Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu 
    210                 215                 220                 


Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr 
225                 230                 235                 240 


Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro 
                245                 250                 255     


Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp 
            260                 265                 270         


Glu 
    


<210>  165
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40L-OX40 DCR

<400>  165

Met Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
1               5                   10                  15      


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
            20                  25                  30          


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Leu Leu Leu Val Ala 
        35                  40                  45              


Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys 
    50                  55                  60                  


Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln 
65                  70                  75                  80  


Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile 
                85                  90                  95      


Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser 
            100                 105                 110         


Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr 
        115                 120                 125             


Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu 
    130                 135                 140                 


Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val 
145                 150                 155                 160 


Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp 
                165                 170                 175     


Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu 
            180                 185                 190         


Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
        195                 200             


<210>  166
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muOX40L-OX40 DCR

<400>  166
atgaggaagg catggcggct tcctaataca cccaagcctt gctggggtaa ttccttcagg       60

actcccatac aggaggaaca tacagacgcc catttcacat tggcaaagat actggtagtg      120

tctggaataa aaggtgcagg tatgttgctg tgcttcatct atgtttgcct tcaattgagc      180

tctagccctg ctaaagaccc acctatccag cggctcaggg gagcagtaac acgctgtgaa      240

gacggtcagt tgtttattag ttcttacaag aacgagtacc agacaatgga agttcaaaat      300

aattctgtcg tcatcaaatg tgacgggttg tatataatat atctgaaagg cagttttttt      360

caagaggtaa agatcgacct gcactttcga gaggatcata atccaatttc tatacctatg      420

ctcaatgatg ggaggcgcat cgtcttcacc gtagtggcca gcctcgcttt taaggacaaa      480

gtttatctca ctgttaatgc acccgataca ctgtgcgagc acctgcaaat taacgatgga      540

gagcttatag ttgtgcaact tactcctgga tattgcgctc ccgaagggtc ttatcatagt      600

actgtaaacc aagtacccct t                                                621


<210>  167
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40L-CD27 DCR

<400>  167

Met Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu 
    50                  55                  60                  


Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His 
65                  70                  75                  80  


Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys 
                85                  90                  95      


Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met 
            100                 105                 110         


Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu 
        115                 120                 125             


Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His 
    130                 135                 140                 


Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser 
145                 150                 155                 160 


Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr 
                165                 170                 175     


Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn 
            180                 185                 190         


Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val 
        195                 200                 205             


Leu 
    


<210>  168
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muOX40L-CD27 DCR

<400>  168
atgcagcgcc gaaatcacgg acctaacgaa gacagacagg cagtaccaga ggagccttgc       60

ccatatagtt gtccaagaga ggaggaaggt tccgctattc ccatccagga ggattatcgc      120

aagcctgagc ctgcattcta cccactggta gtgtctggaa taaaaggtgc aggtatgttg      180

ctgtgcttca tctatgtttg ccttcaattg agctctagcc ctgctaaaga cccacctatc      240

cagcggctca ggggagcagt aacacgctgt gaagacggtc agttgtttat tagttcttac      300

aagaacgagt accagacaat ggaagttcaa aataattctg tcgtcatcaa atgtgacggg      360

ttgtatataa tatatctgaa aggcagtttt tttcaagagg taaagatcga cctgcacttt      420

cgagaggatc ataatccaat ttctatacct atgctcaatg atgggaggcg catcgtcttc      480

accgtagtgg ccagcctcgc ttttaaggac aaagtttatc tcactgttaa tgcacccgat      540

acactgtgcg agcacctgca aattaacgat ggagagctta tagttgtgca acttactcct      600

ggatattgcg ctcccgaagg gtcttatcat agtactgtaa accaagtacc cctt            654


<210>  169
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40L-CD30 DCR

<400>  169

Met Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His 
1               5                   10                  15      


Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp 
            20                  25                  30          


Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val 
        35                  40                  45              


Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met 
    50                  55                  60                  


Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu 
65                  70                  75                  80  


Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro 
                85                  90                  95      


Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile 
            100                 105                 110         


Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu 
        115                 120                 125             


Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu 
    130                 135                 140                 


Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr 
145                 150                 155                 160 


Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu 
                165                 170                 175     


Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys Leu Leu 
            180                 185                 190         


Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr 
        195                 200                 205             


Tyr Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro 
    210                 215                 220                 


Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys 
225                 230                 235                 240 


Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln 
                245                 250                 255     


Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu 
            260                 265                 270         


Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys 
        275                 280                 285             


Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser 
    290                 295                 300                 


Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val 
305                 310                 315                 320 


Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu 
                325                 330                 335     


Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
            340                 345                 350 


<210>  170
<211>  1083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muOX40L-CD30 DCR

<400>  170
atgtactgga aagcatgccg aagaaggttc cagcaaaagt ttcatcttga ctaccttgta       60

caaacctttc agccaaagat ggagcaaact gattcatgtc caaccgagaa attgacacaa      120

cctcagcgca gtgggtccgt aactgaccct agcacagggc acaagctctc tcctgtgtct      180

ccaccacccg ccgttgaaac ttgtgcatct gtcggagcta cctatttgga aaacctccct      240

ctgctcgatg actcacctgc tggtaatcca ttttctccca gagagccccc cgagcctaga      300

gtttccaccg aacatactaa taaccggatt gaaaaaatat atattatgaa agccgacacc      360

gtgatagtag gtagtgtaaa aacagaggtc cctgagggta gagctccagc cggctcaacc      420

gagtcagagc tggaggctga attggaagta gatcacgcac cacattatcc cgagcaggaa      480

actgagcctc ctctcggatc ttgtaccgaa gtgatgttct ccgtagagga aggtgggaag      540

gaggaccacg gaccaacaac agtgtccgag aagctggtag tgtctggaat aaaaggtgca      600

ggtatgttgc tgtgcttcat ctatgtttgc cttcaattga gctctagccc tgctaaagac      660

ccacctatcc agcggctcag gggagcagta acacgctgtg aagacggtca gttgtttatt      720

agttcttaca agaacgagta ccagacaatg gaagttcaaa ataattctgt cgtcatcaaa      780

tgtgacgggt tgtatataat atatctgaaa ggcagttttt ttcaagaggt aaagatcgac      840

ctgcactttc gagaggatca taatccaatt tctataccta tgctcaatga tgggaggcgc      900

atcgtcttca ccgtagtggc cagcctcgct tttaaggaca aagtttatct cactgttaat      960

gcacccgata cactgtgcga gcacctgcaa attaacgatg gagagcttat agttgtgcaa     1020

cttactcctg gatattgcgc tcccgaaggg tcttatcata gtactgtaaa ccaagtaccc     1080

ctt                                                                   1083


<210>  171
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40L-CD40 DCR

<400>  171

Met Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
1               5                   10                  15      


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            20                  25                  30          


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        35                  40                  45              


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Leu 
    50                  55                  60                  


Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe 
65                  70                  75                  80  


Thr Tyr Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr 
                85                  90                  95      


Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu 
            100                 105                 110         


Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val 
        115                 120                 125             


Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser 
    130                 135                 140                 


Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln 
145                 150                 155                 160 


Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn 
                165                 170                 175     


Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn 
            180                 185                 190         


Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly 
        195                 200                 205             


Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
    210                 215                 220             


<210>  172
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muOX40L-CD40 DCR

<400>  172
atgaaaaaag tggttaagaa accaaaggac aacgaaatcc ttcctcccgc agcacgacga       60

caagaccctc aagagatgga agactatccc ggccacaaca ccgcagctcc agtccaagaa      120

acccttcatg ggtgtcaacc tgtaacacag gaagacggga aagagtcaag gatttcagtg      180

caagagcgac aagtgactga cagcatcgct ttgaggccac tggttctggt agtgtctgga      240

ataaaaggtg caggtatgtt gctgtgcttc atctatgttt gccttcaatt gagctctagc      300

cctgctaaag acccacctat ccagcggctc aggggagcag taacacgctg tgaagacggt      360

cagttgttta ttagttctta caagaacgag taccagacaa tggaagttca aaataattct      420

gtcgtcatca aatgtgacgg gttgtatata atatatctga aaggcagttt ttttcaagag      480

gtaaagatcg acctgcactt tcgagaggat cataatccaa tttctatacc tatgctcaat      540

gatgggaggc gcatcgtctt caccgtagtg gccagcctcg cttttaagga caaagtttat      600

ctcactgtta atgcacccga tacactgtgc gagcacctgc aaattaacga tggagagctt      660

atagttgtgc aacttactcc tggatattgc gctcccgaag ggtcttatca tagtactgta      720

aaccaagtac ccctt                                                       735


<210>  173
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40L-HVEM DCR

<400>  173

Met Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile 
1               5                   10                  15      


Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val 
            20                  25                  30          


Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu 
        35                  40                  45              


Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Leu Leu Leu 
    50                  55                  60                  


Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr 
65                  70                  75                  80  


Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro Arg 
                85                  90                  95      


Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly 
            100                 105                 110         


Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn 
        115                 120                 125             


Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys 
    130                 135                 140                 


Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp 
145                 150                 155                 160 


Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu 
                165                 170                 175     


Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr 
            180                 185                 190         


Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu 
        195                 200                 205             


Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
    210                 215                 220     


<210>  174
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muOX40L-HVEM DCR

<400>  174
atgactagac gccacctcca caccagctca gtagcaaagg agctggaacc atttcaagag       60

cagcaggaaa atacaattcg gtttcctgta accgaggttg gctttgctga gactgaggaa      120

gaaactgcta gtaatctggt agtgtctgga ataaaaggtg caggtatgtt gctgtgcttc      180

atctatgttt gccttcaatt gagctctagc cctgctaaag acccacctat ccagcggctc      240

aggggagcag taacacgctg tgaagacggt cagttgttta ttagttctta caagaacgag      300

taccagacaa tggaagttca aaataattct gtcgtcatca aatgtgacgg gttgtatata      360

atatatctga aaggcagttt ttttcaagag gtaaagatcg acctgcactt tcgagaggat      420

cataatccaa tttctatacc tatgctcaat gatgggaggc gcatcgtctt caccgtagtg      480

gccagcctcg cttttaagga caaagtttat ctcactgtta atgcacccga tacactgtgc      540

gagcacctgc aaattaacga tggagagctt atagttgtgc aacttactcc tggatattgc      600

gctcccgaag ggtcttatca tagtactgta aaccaagtac ccctt                      645


<210>  175
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40L-DR3 DCR

<400>  175

Met Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr 
1               5                   10                  15      


Ala Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His 
            20                  25                  30          


Leu Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser 
        35                  40                  45              


Ser Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro 
    50                  55                  60                  


Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser 
65                  70                  75                  80  


Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr 
                85                  90                  95      


Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro 
            100                 105                 110         


Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp 
        115                 120                 125             


Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala 
    130                 135                 140                 


Val Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu 
145                 150                 155                 160 


Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala 
                165                 170                 175     


Ala Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser 
            180                 185                 190         


Arg Leu Gln Arg Gly Pro Leu Leu Leu Val Ala Ser Val Ile Gln Gly 
        195                 200                 205             


Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala 
    210                 215                 220                 


Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln 
225                 230                 235                 240 


Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys 
                245                 250                 255     


Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys 
            260                 265                 270         


Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val 
        275                 280                 285             


Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu 
    290                 295                 300                 


Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr 
305                 310                 315                 320 


Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp 
                325                 330                 335     


Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro 
            340                 345                 350         


Gly Glu Phe Cys Val Leu 
        355             


<210>  176
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muOX40L-DR3 DCR

<400>  176
atgatttgcg cctactgcag atggcagcct tgcaaggcag tagttactgc tgataccgct       60

ggcacagaaa ctttggcatc cccacagact gctcatctgt ccgcatctga ttccgctcat      120

actctcctcg cccctcctag cagtacagga aaaatatgta ctaccgtgca actcgtcgga      180

aacaactgga cccccgggct ttctcaaact caagaggtcg tatgtgggca ggcttcacaa      240

ccatgggatc aactgccaaa taggaccctt ggtacaccac tggcttcacc tctgtctccc      300

gcccccccag ctggatctcc tgccgccgtc cttcagcccg gtccccagct ctacgacgta      360

atggatgctg tacctgctag gagatggaaa gagttcgtga ggaccctcgg tctgagggaa      420

gctgagatcg aagccgtaga agtggaaatc tgccgattcc gggatcaaca gtatgagatg      480

ctcaagcgat ggaggcaaca acagcccgcc gggctgggcg ctatttacgc tgctcttgag      540

cgcatgggac tggagggatg cgctgaagat ctgagatcaa ggctccagcg ggggcccctg      600

gtagtgtctg gaataaaagg tgcaggtatg ttgctgtgct tcatctatgt ttgccttcaa      660

ttgagctcta gccctgctaa agacccacct atccagcggc tcaggggagc agtaacacgc      720

tgtgaagacg gtcagttgtt tattagttct tacaagaacg agtaccagac aatggaagtt      780

caaaataatt ctgtcgtcat caaatgtgac gggttgtata taatatatct gaaaggcagt      840

ttttttcaag aggtaaagat cgacctgcac tttcgagagg atcataatcc aatttctata      900

cctatgctca atgatgggag gcgcatcgtc ttcaccgtag tggccagcct cgcttttaag      960

gacaaagttt atctcactgt taatgcaccc gatacactgt gcgagcacct gcaaattaac     1020

gatggagagc ttatagttgt gcaacttact cctggatatt gcgctcccga agggtcttat     1080

catagtactg taaaccaagt acccctt                                         1107


<210>  177
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40L-41BB DCR

<400>  177

Met Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Leu Leu Leu Val Ala 
        35                  40                  45              


Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys 
    50                  55                  60                  


Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln 
65                  70                  75                  80  


Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile 
                85                  90                  95      


Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser 
            100                 105                 110         


Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr 
        115                 120                 125             


Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu 
    130                 135                 140                 


Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val 
145                 150                 155                 160 


Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp 
                165                 170                 175     


Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu 
            180                 185                 190         


Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
        195                 200             


<210>  178
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muOX40L-41BB DCR

<400>  178
atgtccgttc tcaaatggat cagaaaaaag ttcccccaca tctttaaaca accattcaag       60

aaaaccactg gggcagctca agaggaggac gcttgctctt gtcggtgtcc acaggaagag      120

gaaggtggtg gcggtggtta cgagttgctg gtagtgtctg gaataaaagg tgcaggtatg      180

ttgctgtgct tcatctatgt ttgccttcaa ttgagctcta gccctgctaa agacccacct      240

atccagcggc tcaggggagc agtaacacgc tgtgaagacg gtcagttgtt tattagttct      300

tacaagaacg agtaccagac aatggaagtt caaaataatt ctgtcgtcat caaatgtgac      360

gggttgtata taatatatct gaaaggcagt ttttttcaag aggtaaagat cgacctgcac      420

tttcgagagg atcataatcc aatttctata cctatgctca atgatgggag gcgcatcgtc      480

ttcaccgtag tggccagcct cgcttttaag gacaaagttt atctcactgt taatgcaccc      540

gatacactgt gcgagcacct gcaaattaac gatggagagc ttatagttgt gcaacttact      600

cctggatatt gcgctcccga agggtcttat catagtactg taaaccaagt acccctt         657


<210>  179
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40L-OX40 DCR

<400>  179

Met Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
1               5                   10                  15      


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
            20                  25                  30          


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Ile Phe Met Tyr Leu 
        35                  40                  45              


Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala 
    50                  55                  60                  


Val Tyr Leu His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu 
65                  70                  75                  80  


His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly 
                85                  90                  95      


Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe 
            100                 105                 110         


Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys 
        115                 120                 125             


Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala 
    130                 135                 140                 


Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln 
145                 150                 155                 160 


Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
                165                 170                 175     


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile 
            180                 185                 190         


Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala 
        195                 200                 205             


Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg 
    210                 215                 220                 


Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly 
225                 230                 235                 240 


Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala 
                245                 250                 255     


Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr 
            260                 265                 270         


Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
        275                 280         


<210>  180
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muCD40L-OX40 DCR

<400>  180
atgaggaagg catggcggct tcctaataca cccaagcctt gctggggtaa ttccttcagg       60

actcccatac aggaggaaca tacagacgcc catttcacat tggcaaagat aattttcatg      120

tatctgctga ccgtctttct catcactcag atgattggga gtgtcctgtt cgcggtctat      180

ctgcataggc gcctggacaa ggtcgaagag gaggtcaacc tgcacgagga ctttgtcttt      240

atcaagaagt tgaagcggtg caacaagggc gaaggatctc tgagcctcct gaactgtgaa      300

gaaatgcgcc gacagtttga ggatctggta aaagacataa cgcttaacaa ggaagaaaag      360

aaggagaatt ctttcgagat gcaacgcggc gatgaggatc cacagatcgc cgcgcacgtc      420

gtctcagagg ccaattcaaa cgcagcctca gtacttcaat gggcgaaaaa ggggtattac      480

accatgaagt ctaatcttgt tatgctagag aatgggaagc agctgacagt gaagcgcgag      540

gggctgtact atgtatatac acaagttacc ttctgcagca atagggagcc aagtagccag      600

cgccccttta tcgtggggct gtggctcaaa cccagcagcg gctccgaacg tattctgctt      660

aaggctgcca acactcacag ttcaagccag ctgtgcgagc agcagtccgt acatcttggc      720

ggagtctttg agctccaggc tggcgcctca gtgttcgtga acgttaccga agcttctcag      780

gttattcacc gggtgggctt ttcttccttt ggactgctga aactc                      825


<210>  181
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40L-CD27 DCR

<400>  181

Met Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro Ile Phe Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile 
    50                  55                  60                  


Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg Arg Leu Asp Lys Ile 
65                  70                  75                  80  


Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile 
                85                  90                  95      


Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu 
            100                 105                 110         


Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn 
        115                 120                 125             


Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp 
    130                 135                 140                 


Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys 
145                 150                 155                 160 


Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser 
                165                 170                 175     


Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg 
            180                 185                 190         


Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg 
        195                 200                 205             


Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser 
    210                 215                 220                 


Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser 
225                 230                 235                 240 


Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe 
                245                 250                 255     


Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser 
            260                 265                 270         


Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
        275                 280                 285             


<210>  182
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muCD40L-CD27 DCR

<400>  182
atgcagcgcc gaaatcacgg acctaacgaa gacagacagg cagtaccaga ggagccttgc       60

ccatatagtt gtccaagaga ggaggaaggt tccgctattc ccatccagga ggattatcgc      120

aagcctgagc ctgcattcta cccaattttc atgtatctgc tgaccgtctt tctcatcact      180

cagatgattg ggagtgtcct gttcgcggtc tatctgcata ggcgcctgga caaggtcgaa      240

gaggaggtca acctgcacga ggactttgtc tttatcaaga agttgaagcg gtgcaacaag      300

ggcgaaggat ctctgagcct cctgaactgt gaagaaatgc gccgacagtt tgaggatctg      360

gtaaaagaca taacgcttaa caaggaagaa aagaaggaga attctttcga gatgcaacgc      420

ggcgatgagg atccacagat cgccgcgcac gtcgtctcag aggccaattc aaacgcagcc      480

tcagtacttc aatgggcgaa aaaggggtat tacaccatga agtctaatct tgttatgcta      540

gagaatggga agcagctgac agtgaagcgc gaggggctgt actatgtata tacacaagtt      600

accttctgca gcaataggga gccaagtagc cagcgcccct ttatcgtggg gctgtggctc      660

aaacccagca gcggctccga acgtattctg cttaaggctg ccaacactca cagttcaagc      720

cagctgtgcg agcagcagtc cgtacatctt ggcggagtct ttgagctcca ggctggcgcc      780

tcagtgttcg tgaacgttac cgaagcttct caggttattc accgggtggg cttttcttcc      840

tttggactgc tgaaactc                                                    858


<210>  183
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40L-CD30 DCR

<400>  183

Met Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His 
1               5                   10                  15      


Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp 
            20                  25                  30          


Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val 
        35                  40                  45              


Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met 
    50                  55                  60                  


Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu 
65                  70                  75                  80  


Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro 
                85                  90                  95      


Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile 
            100                 105                 110         


Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu 
        115                 120                 125             


Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu 
    130                 135                 140                 


Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr 
145                 150                 155                 160 


Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu 
                165                 170                 175     


Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys Ile Phe 
            180                 185                 190         


Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly Ser Ala 
        195                 200                 205             


Leu Phe Ala Val Tyr Leu His Arg Arg Leu Asp Lys Ile Glu Asp Glu 
    210                 215                 220                 


Arg Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys 
225                 230                 235                 240 


Asn Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys 
                245                 250                 255     


Ser Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu 
            260                 265                 270         


Thr Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro 
        275                 280                 285             


Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser 
    290                 295                 300                 


Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu 
305                 310                 315                 320 


Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu 
                325                 330                 335     


Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser 
            340                 345                 350         


Ser Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg 
        355                 360                 365             


Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys 
    370                 375                 380                 


Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln 
385                 390                 395                 400 


Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser 
                405                 410                 415     


His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
            420                 425                 


<210>  184
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muCD40L-CD30 DCR

<400>  184
atgtactgga aagcatgccg aagaaggttc cagcaaaagt ttcatcttga ctaccttgta       60

caaacctttc agccaaagat ggagcaaact gattcatgtc caaccgagaa attgacacaa      120

cctcagcgca gtgggtccgt aactgaccct agcacagggc acaagctctc tcctgtgtct      180

ccaccacccg ccgttgaaac ttgtgcatct gtcggagcta cctatttgga aaacctccct      240

ctgctcgatg actcacctgc tggtaatcca ttttctccca gagagccccc cgagcctaga      300

gtttccaccg aacatactaa taaccggatt gaaaaaatat atattatgaa agccgacacc      360

gtgatagtag gtagtgtaaa aacagaggtc cctgagggta gagctccagc cggctcaacc      420

gagtcagagc tggaggctga attggaagta gatcacgcac cacattatcc cgagcaggaa      480

actgagcctc ctctcggatc ttgtaccgaa gtgatgttct ccgtagagga aggtgggaag      540

gaggaccacg gaccaacaac agtgtccgag aagattttca tgtatctgct gaccgtcttt      600

ctcatcactc agatgattgg gagtgtcctg ttcgcggtct atctgcatag gcgcctggac      660

aaggtcgaag aggaggtcaa cctgcacgag gactttgtct ttatcaagaa gttgaagcgg      720

tgcaacaagg gcgaaggatc tctgagcctc ctgaactgtg aagaaatgcg ccgacagttt      780

gaggatctgg taaaagacat aacgcttaac aaggaagaaa agaaggagaa ttctttcgag      840

atgcaacgcg gcgatgagga tccacagatc gccgcgcacg tcgtctcaga ggccaattca      900

aacgcagcct cagtacttca atgggcgaaa aaggggtatt acaccatgaa gtctaatctt      960

gttatgctag agaatgggaa gcagctgaca gtgaagcgcg aggggctgta ctatgtatat     1020

acacaagtta ccttctgcag caatagggag ccaagtagcc agcgcccctt tatcgtgggg     1080

ctgtggctca aacccagcag cggctccgaa cgtattctgc ttaaggctgc caacactcac     1140

agttcaagcc agctgtgcga gcagcagtcc gtacatcttg gcggagtctt tgagctccag     1200

gctggcgcct cagtgttcgt gaacgttacc gaagcttctc aggttattca ccgggtgggc     1260

ttttcttcct ttggactgct gaaactc                                         1287


<210>  185
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40L-CD40 DCR

<400>  185

Met Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
1               5                   10                  15      


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            20                  25                  30          


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        35                  40                  45              


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Ile 
    50                  55                  60                  


Phe Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly Ser 
65                  70                  75                  80  


Ala Leu Phe Ala Val Tyr Leu His Arg Arg Leu Asp Lys Ile Glu Asp 
                85                  90                  95      


Glu Arg Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg 
            100                 105                 110         


Cys Asn Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile 
        115                 120                 125             


Lys Ser Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu 
    130                 135                 140                 


Glu Thr Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn 
145                 150                 155                 160 


Pro Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr 
                165                 170                 175     


Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn 
            180                 185                 190         


Leu Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly 
        195                 200                 205             


Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala 
    210                 215                 220                 


Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly 
225                 230                 235                 240 


Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala 
                245                 250                 255     


Lys Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu 
            260                 265                 270         


Gln Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val 
        275                 280                 285             


Ser His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
    290                 295                 300         


<210>  186
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muCD40L-CD40 DCR

<400>  186
atgaaaaaag tggttaagaa accaaaggac aacgaaatcc ttcctcccgc agcacgacga       60

caagaccctc aagagatgga agactatccc ggccacaaca ccgcagctcc agtccaagaa      120

acccttcatg ggtgtcaacc tgtaacacag gaagacggga aagagtcaag gatttcagtg      180

caagagcgac aagtgactga cagcatcgct ttgaggccac tggttatttt catgtatctg      240

ctgaccgtct ttctcatcac tcagatgatt gggagtgtcc tgttcgcggt ctatctgcat      300

aggcgcctgg acaaggtcga agaggaggtc aacctgcacg aggactttgt ctttatcaag      360

aagttgaagc ggtgcaacaa gggcgaagga tctctgagcc tcctgaactg tgaagaaatg      420

cgccgacagt ttgaggatct ggtaaaagac ataacgctta acaaggaaga aaagaaggag      480

aattctttcg agatgcaacg cggcgatgag gatccacaga tcgccgcgca cgtcgtctca      540

gaggccaatt caaacgcagc ctcagtactt caatgggcga aaaaggggta ttacaccatg      600

aagtctaatc ttgttatgct agagaatggg aagcagctga cagtgaagcg cgaggggctg      660

tactatgtat atacacaagt taccttctgc agcaataggg agccaagtag ccagcgcccc      720

tttatcgtgg ggctgtggct caaacccagc agcggctccg aacgtattct gcttaaggct      780

gccaacactc acagttcaag ccagctgtgc gagcagcagt ccgtacatct tggcggagtc      840

tttgagctcc aggctggcgc ctcagtgttc gtgaacgtta ccgaagcttc tcaggttatt      900

caccgggtgg gcttttcttc ctttggactg ctgaaactc                             939


<210>  187
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40L-HVEM DCR

<400>  187

Met Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile 
1               5                   10                  15      


Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val 
            20                  25                  30          


Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu 
        35                  40                  45              


Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Ile Phe Met 
    50                  55                  60                  


Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly Ser Ala Leu 
65                  70                  75                  80  


Phe Ala Val Tyr Leu His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg 
                85                  90                  95      


Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn 
            100                 105                 110         


Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser 
        115                 120                 125             


Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr 
    130                 135                 140                 


Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln 
145                 150                 155                 160 


Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val 
                165                 170                 175     


Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val 
            180                 185                 190         


Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr 
        195                 200                 205             


Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser 
    210                 215                 220                 


Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe 
225                 230                 235                 240 


Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro 
                245                 250                 255     


Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro 
            260                 265                 270         


Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His 
        275                 280                 285             


Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
    290                 295                 300 


<210>  188
<211>  849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muCD40L-HVEM DCR

<400>  188
atgactagac gccacctcca caccagctca gtagcaaagg agctggaacc atttcaagag       60

cagcaggaaa atacaattcg gtttcctgta accgaggttg gctttgctga gactgaggaa      120

gaaactgcta gtaatatttt catgtatctg ctgaccgtct ttctcatcac tcagatgatt      180

gggagtgtcc tgttcgcggt ctatctgcat aggcgcctgg acaaggtcga agaggaggtc      240

aacctgcacg aggactttgt ctttatcaag aagttgaagc ggtgcaacaa gggcgaagga      300

tctctgagcc tcctgaactg tgaagaaatg cgccgacagt ttgaggatct ggtaaaagac      360

ataacgctta acaaggaaga aaagaaggag aattctttcg agatgcaacg cggcgatgag      420

gatccacaga tcgccgcgca cgtcgtctca gaggccaatt caaacgcagc ctcagtactt      480

caatgggcga aaaaggggta ttacaccatg aagtctaatc ttgttatgct agagaatggg      540

aagcagctga cagtgaagcg cgaggggctg tactatgtat atacacaagt taccttctgc      600

agcaataggg agccaagtag ccagcgcccc tttatcgtgg ggctgtggct caaacccagc      660

agcggctccg aacgtattct gcttaaggct gccaacactc acagttcaag ccagctgtgc      720

gagcagcagt ccgtacatct tggcggagtc tttgagctcc aggctggcgc ctcagtgttc      780

gtgaacgtta ccgaagcttc tcaggttatt caccgggtgg gcttttcttc ctttggactg      840

ctgaaactc                                                              849


<210>  189
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40L-DR3 DCR

<400>  189

Met Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr 
1               5                   10                  15      


Ala Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His 
            20                  25                  30          


Leu Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser 
        35                  40                  45              


Ser Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro 
    50                  55                  60                  


Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser 
65                  70                  75                  80  


Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr 
                85                  90                  95      


Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro 
            100                 105                 110         


Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp 
        115                 120                 125             


Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala 
    130                 135                 140                 


Val Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu 
145                 150                 155                 160 


Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala 
                165                 170                 175     


Ala Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser 
            180                 185                 190         


Arg Leu Gln Arg Gly Pro Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
        195                 200                 205             


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
    210                 215                 220                 


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
225                 230                 235                 240 


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
                245                 250                 255     


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
            260                 265                 270         


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
        275                 280                 285             


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
    290                 295                 300                 


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
305                 310                 315                 320 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
                325                 330                 335     


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
            340                 345                 350         


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
        355                 360                 365             


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
    370                 375                 380                 


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
385                 390                 395                 400 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
                405                 410                 415     


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
            420                 425                 430         


Gly Leu Leu Lys Leu 
        435         


<210>  190
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muCD40L-DR3 DCR

<400>  190
atgatttgcg cctactgcag atggcagcct tgcaaggcag tagttactgc tgataccgct       60

ggcacagaaa ctttggcatc cccacagact gctcatctgt ccgcatctga ttccgctcat      120

actctcctcg cccctcctag cagtacagga aaaatatgta ctaccgtgca actcgtcgga      180

aacaactgga cccccgggct ttctcaaact caagaggtcg tatgtgggca ggcttcacaa      240

ccatgggatc aactgccaaa taggaccctt ggtacaccac tggcttcacc tctgtctccc      300

gcccccccag ctggatctcc tgccgccgtc cttcagcccg gtccccagct ctacgacgta      360

atggatgctg tacctgctag gagatggaaa gagttcgtga ggaccctcgg tctgagggaa      420

gctgagatcg aagccgtaga agtggaaatc tgccgattcc gggatcaaca gtatgagatg      480

ctcaagcgat ggaggcaaca acagcccgcc gggctgggcg ctatttacgc tgctcttgag      540

cgcatgggac tggagggatg cgctgaagat ctgagatcaa ggctccagcg ggggcccatt      600

ttcatgtatc tgctgaccgt ctttctcatc actcagatga ttgggagtgt cctgttcgcg      660

gtctatctgc ataggcgcct ggacaaggtc gaagaggagg tcaacctgca cgaggacttt      720

gtctttatca agaagttgaa gcggtgcaac aagggcgaag gatctctgag cctcctgaac      780

tgtgaagaaa tgcgccgaca gtttgaggat ctggtaaaag acataacgct taacaaggaa      840

gaaaagaagg agaattcttt cgagatgcaa cgcggcgatg aggatccaca gatcgccgcg      900

cacgtcgtct cagaggccaa ttcaaacgca gcctcagtac ttcaatgggc gaaaaagggg      960

tattacacca tgaagtctaa tcttgttatg ctagagaatg ggaagcagct gacagtgaag     1020

cgcgaggggc tgtactatgt atatacacaa gttaccttct gcagcaatag ggagccaagt     1080

agccagcgcc cctttatcgt ggggctgtgg ctcaaaccca gcagcggctc cgaacgtatt     1140

ctgcttaagg ctgccaacac tcacagttca agccagctgt gcgagcagca gtccgtacat     1200

cttggcggag tctttgagct ccaggctggc gcctcagtgt tcgtgaacgt taccgaagct     1260

tctcaggtta ttcaccgggt gggcttttct tcctttggac tgctgaaact c              1311


<210>  191
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40L-41BB DCR

<400>  191

Met Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ile Phe Met Tyr Leu 
        35                  40                  45              


Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala 
    50                  55                  60                  


Val Tyr Leu His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu 
65                  70                  75                  80  


His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly 
                85                  90                  95      


Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe 
            100                 105                 110         


Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys 
        115                 120                 125             


Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala 
    130                 135                 140                 


Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln 
145                 150                 155                 160 


Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
                165                 170                 175     


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile 
            180                 185                 190         


Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala 
        195                 200                 205             


Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg 
    210                 215                 220                 


Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly 
225                 230                 235                 240 


Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala 
                245                 250                 255     


Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr 
            260                 265                 270         


Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
        275                 280         


<210>  192
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muCD40L-41BB DCR

<400>  192
atgtccgttc tcaaatggat cagaaaaaag ttcccccaca tctttaaaca accattcaag       60

aaaaccactg gggcagctca agaggaggac gcttgctctt gtcggtgtcc acaggaagag      120

gaaggtggtg gcggtggtta cgagttgatt ttcatgtatc tgctgaccgt ctttctcatc      180

actcagatga ttgggagtgt cctgttcgcg gtctatctgc ataggcgcct ggacaaggtc      240

gaagaggagg tcaacctgca cgaggacttt gtctttatca agaagttgaa gcggtgcaac      300

aagggcgaag gatctctgag cctcctgaac tgtgaagaaa tgcgccgaca gtttgaggat      360

ctggtaaaag acataacgct taacaaggaa gaaaagaagg agaattcttt cgagatgcaa      420

cgcggcgatg aggatccaca gatcgccgcg cacgtcgtct cagaggccaa ttcaaacgca      480

gcctcagtac ttcaatgggc gaaaaagggg tattacacca tgaagtctaa tcttgttatg      540

ctagagaatg ggaagcagct gacagtgaag cgcgaggggc tgtactatgt atatacacaa      600

gttaccttct gcagcaatag ggagccaagt agccagcgcc cctttatcgt ggggctgtgg      660

ctcaaaccca gcagcggctc cgaacgtatt ctgcttaagg ctgccaacac tcacagttca      720

agccagctgt gcgagcagca gtccgtacat cttggcggag tctttgagct ccaggctggc      780

gcctcagtgt tcgtgaacgt taccgaagct tctcaggtta ttcaccgggt gggcttttct      840

tcctttggac tgctgaaact c                                                861


<210>  193
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFLT3L-OX40 DCR

<400>  193

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu Ala Leu Tyr 
        195                 200                 205             


Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro 
    210                 215                 220                 


Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala 
225                 230                 235                 240 


His Ser Thr Leu Ala Lys Ile 
                245         


<210>  194
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFLT3L-CD27 DCR

<400>  194

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu Gln Arg Arg 
        195                 200                 205             


Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro 
    210                 215                 220                 


Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile 
225                 230                 235                 240 


Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
                245                 250             


<210>  195
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFLT3L-CD30 DCR

<400>  195

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu Cys His Arg 
        195                 200                 205             


Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr Pro 
    210                 215                 220                 


Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro Arg 
225                 230                 235                 240 


Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro Val 
                245                 250                 255     


Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys His 
            260                 265                 270         


Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala Ser 
        275                 280                 285             


Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg Val 
    290                 295                 300                 


Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met Lys 
305                 310                 315                 320 


Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu Gly 
                325                 330                 335     


Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu Glu 
            340                 345                 350         


Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro Leu 
        355                 360                 365             


Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys Glu 
    370                 375                 380                 


Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
385                 390                 


<210>  196
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFLT3L-CD40 DCR

<400>  196

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu Lys Lys Val 
        195                 200                 205             


Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln 
    210                 215                 220                 


Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro 
225                 230                 235                 240 


Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly 
                245                 250                 255     


Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            260                 265         


<210>  197
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFLT3L-HVEM DCR

<400>  197

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu Cys Val Lys 
        195                 200                 205             


Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser Val Gln 
    210                 215                 220                 


Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu Ala Leu 
225                 230                 235                 240 


Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr Ile Pro 
                245                 250                 255     


Ser Phe Thr Gly Arg Ser Pro Asn His 
            260                 265 


<210>  198
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFLT3L-DR3 DCR

<400>  198

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu Thr Tyr Thr 
        195                 200                 205             


Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala 
    210                 215                 220                 


Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu 
225                 230                 235                 240 


Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile 
                245                 250                 255     


Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu 
            260                 265                 270         


Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu 
        275                 280                 285             


Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu 
    290                 295                 300                 


Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu 
305                 310                 315                 320 


Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val 
                325                 330                 335     


Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu 
            340                 345                 350         


Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg 
        355                 360                 365             


Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg 
    370                 375                 380                 


Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg 
385                 390                 395                 400 


Gly Pro 
        


<210>  199
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huFLT3tm-41BB DCR

<400>  199

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu Lys Arg Gly 
        195                 200                 205             


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
    210                 215                 220                 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
225                 230                 235                 240 


Glu Glu Gly Gly Cys Glu Leu 
                245         


<210>  200
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huLIGHT-OX40 DCR

<400>  200

Met Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
1               5                   10                  15      


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
            20                  25                  30          


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Val Gly Leu Gly Leu 
        35                  40                  45              


Leu Leu Leu Leu Met Gly Ala Gly Leu Ala Val Gln Gly Trp Phe Leu 
    50                  55                  60                  


Leu Gln Leu His Trp Arg Leu Gly Glu Met Val Thr Arg Leu Pro Asp 
65                  70                  75                  80  


Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His 
                85                  90                  95      


Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
            100                 105                 110         


Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
        115                 120                 125             


Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
    130                 135                 140                 


Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
145                 150                 155                 160 


Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
                165                 170                 175     


Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
            180                 185                 190         


Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
        195                 200                 205             


Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val Val Val Arg 
    210                 215                 220                 


Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
225                 230                 235                 240 


Phe Gly Ala Phe Met Val 
                245     


<210>  201
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huLIGHT-CD27 DCR

<400>  201

Met Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly Ala Gly Leu Ala 
    50                  55                  60                  


Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg Leu Gly Glu Met 
65                  70                  75                  80  


Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile 
                85                  90                  95      


Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly 
            100                 105                 110         


Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
        115                 120                 125             


Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
    130                 135                 140                 


Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
145                 150                 155                 160 


Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
                165                 170                 175     


Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
            180                 185                 190         


Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
        195                 200                 205             


Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
    210                 215                 220                 


Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
225                 230                 235                 240 


Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
                245                 250         


<210>  202
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huLIGHT-CD30 DCR

<400>  202

Met Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His 
1               5                   10                  15      


Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp 
            20                  25                  30          


Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val 
        35                  40                  45              


Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met 
    50                  55                  60                  


Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu 
65                  70                  75                  80  


Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro 
                85                  90                  95      


Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile 
            100                 105                 110         


Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu 
        115                 120                 125             


Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu 
    130                 135                 140                 


Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr 
145                 150                 155                 160 


Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu 
                165                 170                 175     


Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys Val Gly 
            180                 185                 190         


Leu Gly Leu Leu Leu Leu Leu Met Gly Ala Gly Leu Ala Val Gln Gly 
        195                 200                 205             


Trp Phe Leu Leu Gln Leu His Trp Arg Leu Gly Glu Met Val Thr Arg 
    210                 215                 220                 


Leu Pro Asp Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg 
225                 230                 235                 240 


Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser 
                245                 250                 255     


Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly 
            260                 265                 270         


Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val 
        275                 280                 285             


Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly 
    290                 295                 300                 


Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr 
305                 310                 315                 320 


Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln 
                325                 330                 335     


Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp 
            340                 345                 350         


Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val 
        355                 360                 365             


Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr 
    370                 375                 380                 


Arg Ser Tyr Phe Gly Ala Phe Met Val 
385                 390             


<210>  203
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huLIGHT-CD40 DCR

<400>  203

Met Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
1               5                   10                  15      


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
            20                  25                  30          


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
        35                  40                  45              


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Val 
    50                  55                  60                  


Gly Leu Gly Leu Leu Leu Leu Leu Met Gly Ala Gly Leu Ala Val Gln 
65                  70                  75                  80  


Gly Trp Phe Leu Leu Gln Leu His Trp Arg Leu Gly Glu Met Val Thr 
                85                  90                  95      


Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu 
            100                 105                 110         


Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn 
        115                 120                 125             


Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu 
    130                 135                 140                 


Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val 
145                 150                 155                 160 


Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly 
                165                 170                 175     


Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu 
            180                 185                 190         


Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser 
        195                 200                 205             


Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp 
    210                 215                 220                 


Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys 
225                 230                 235                 240 


Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly 
                245                 250                 255     


Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
            260                 265     


<210>  204
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huLIGHT-HVEM DCR

<400>  204

Met Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile 
1               5                   10                  15      


Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val 
            20                  25                  30          


Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu 
        35                  40                  45              


Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His Val Gly Leu 
    50                  55                  60                  


Gly Leu Leu Leu Leu Leu Met Gly Ala Gly Leu Ala Val Gln Gly Trp 
65                  70                  75                  80  


Phe Leu Leu Gln Leu His Trp Arg Leu Gly Glu Met Val Thr Arg Leu 
                85                  90                  95      


Pro Asp Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg 
            100                 105                 110         


Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
        115                 120                 125             


Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
    130                 135                 140                 


Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
                165                 170                 175     


Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
            180                 185                 190         


Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
        195                 200                 205             


Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
    210                 215                 220                 


Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val Val 
225                 230                 235                 240 


Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
                245                 250                 255     


Ser Tyr Phe Gly Ala Phe Met Val 
            260                 


<210>  205
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huLIGHT-DR3 DCR

<400>  205

Met Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr 
1               5                   10                  15      


Ala Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His 
            20                  25                  30          


Leu Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser 
        35                  40                  45              


Ser Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro 
    50                  55                  60                  


Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser 
65                  70                  75                  80  


Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr 
                85                  90                  95      


Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro 
            100                 105                 110         


Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp 
        115                 120                 125             


Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala 
    130                 135                 140                 


Val Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu 
145                 150                 155                 160 


Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala 
                165                 170                 175     


Ala Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser 
            180                 185                 190         


Arg Leu Gln Arg Gly Pro Val Gly Leu Gly Leu Leu Leu Leu Leu Met 
        195                 200                 205             


Gly Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp 
    210                 215                 220                 


Arg Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser 
225                 230                 235                 240 


Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala 
                245                 250                 255     


Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro 
            260                 265                 270         


Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser 
        275                 280                 285             


Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile 
    290                 295                 300                 


Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala 
305                 310                 315                 320 


Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu 
                325                 330                 335     


Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr 
            340                 345                 350         


Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val 
        355                 360                 365             


His Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg 
    370                 375                 380                 


Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met 
385                 390                 395                 400 


Val 
    


<210>  206
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huLIGHT-41BB DCR

<400>  206

Met Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Gly Leu Gly Leu 
        35                  40                  45              


Leu Leu Leu Leu Met Gly Ala Gly Leu Ala Val Gln Gly Trp Phe Leu 
    50                  55                  60                  


Leu Gln Leu His Trp Arg Leu Gly Glu Met Val Thr Arg Leu Pro Asp 
65                  70                  75                  80  


Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His 
                85                  90                  95      


Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
            100                 105                 110         


Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
        115                 120                 125             


Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
    130                 135                 140                 


Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
145                 150                 155                 160 


Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
                165                 170                 175     


Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
            180                 185                 190         


Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
        195                 200                 205             


Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val Val Val Arg 
    210                 215                 220                 


Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
225                 230                 235                 240 


Phe Gly Ala Phe Met Val 
                245     


<210>  207
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Furin cleavage + SGS linker for the 3 end of the human 
       costimulatory constructs

<400>  207
cgtgcaaaac gttcaggctc aggt                                              24


<210>  208
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12 domain

<400>  208

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Trp His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  209
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild-type FRB segment of mTOR

<400>  209

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  210
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB (with T to L substitution at 2098 which allows binding to 
       AP21967)

<400>  210

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  211
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB segment of mTOR with substitutions

<400>  211

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu His Gln Ala Phe Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  212
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRB segment of mTOR with substitutions

<400>  212

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Pro Asp 
65                  70                  75                  80  


Leu Thr Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Ser 
            100 


<210>  213
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EcR

<400>  213

Met Pro Val Asp Arg Ile Leu Glu Ala Glu Leu Ala Val Glu Gln Lys 
1               5                   10                  15      


Ser Asp Gln Gly Val Glu Gly Pro Gly Gly Thr Gly Gly Ser Gly Ser 
            20                  25                  30          


Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala Asp Lys Gln 
        35                  40                  45              


Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His Phe Ser Ser 
    50                  55                  60                  


Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly Trp Asn Glu 
65                  70                  75                  80  


Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Asp Val Arg Asp Gly 
                85                  90                  95      


Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser Ala His Ser 
            100                 105                 110         


Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu Leu Val Ser 
        115                 120                 125             


Lys Met Arg Asp Met Arg Met Asp Lys Thr Glu Leu Gly Cys Leu Arg 
    130                 135                 140                 


Ala Ile Ile Leu Phe Asn Pro Glu Val Arg Gly Leu Lys Ser Ala Gln 
145                 150                 155                 160 


Glu Val Glu Leu Leu Arg Glu Lys Val Tyr Ala Ala Leu Glu Glu Tyr 
                165                 170                 175     


Thr Arg Thr Thr His Pro Asp Glu Pro Gly Arg Phe Ala Lys Leu Leu 
            180                 185                 190         


Leu Arg Leu Pro Ser Leu Arg Ser Ile Gly Leu Lys Cys Leu Glu His 
        195                 200                 205             


Leu Phe Phe Phe Arg Leu Ile Gly Asp Val Pro Ile Asp Thr Phe Leu 
    210                 215                 220                 


Met Glu Met Leu Glu Ser Pro Ser Asp Ser 
225                 230                 


<210>  214
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RXR

<400>  214

Arg Pro Glu Cys Val Val Pro Glu Thr Gln Cys Ala Met Lys Arg Lys 
1               5                   10                  15      


Glu Lys Lys Ala Gln Lys Glu Lys Asp Lys Leu Pro Val Ser Ile Thr 
            20                  25                  30          


Thr Val Asp Asp His Met Pro Pro Ile Met Gln Cys Glu Pro Pro Pro 
        35                  40                  45              


Pro Glu Ala Ala Arg Ile His Glu Val Val Pro Arg Phe Leu Ser Asp 
    50                  55                  60                  


Lys Leu Leu Glu Thr Asn Arg Gln Lys Asn Ile Pro Gln Leu Thr Ala 
65                  70                  75                  80  


Asn Gln Gln Phe Leu Ile Ala Arg Leu Ile Trp Tyr Gln Asp Gly Tyr 
                85                  90                  95      


Glu Gln Pro Ser Asp Glu Asp Leu Lys Arg Ile Thr Gln Thr Val Val 
            100                 105                 110         


Gln Gln Ala Asp Asp Glu Asn Glu Glu Ser Asp Thr Pro Phe Arg Gln 
        115                 120                 125             


Ile Thr Glu Met Thr Ile Leu Thr Val Gln Leu Ile Val Glu Phe Ala 
    130                 135                 140                 


Lys Gly Leu Pro Gly Phe Ala Lys Ile Ser Gln Pro Asp Gln Ile Thr 
145                 150                 155                 160 


Leu Leu Lys Ala Cys Ser Ser Glu Val Met Met Leu Arg Val Ala Arg 
                165                 170                 175     


Arg Tyr Asp Ala Ala Ser Asp Ser Ile Leu Phe Ala Asn Asn Gln Ala 
            180                 185                 190         


Tyr Thr Arg Asp Asn Tyr Arg Lys Ala Gly Met Ala Glu Val Ile Glu 
        195                 200                 205             


Asp Leu Leu His Phe Cys Arg Cys Met Tyr Ser Met Ala Leu Asp Asn 
    210                 215                 220                 


Ile His Tyr Ala Leu Leu Thr Ala Val Val Ile Phe Ser Asp Arg Pro 
225                 230                 235                 240 


Gly Leu Glu Gln Pro Gln Leu Val Glu Glu Ile Gln Arg Tyr Tyr Leu 
                245                 250                 255     


Asn Thr Leu Arg Ile Tyr Ile Leu Asn Gln Leu Ser Gly Ser Ala Arg 
            260                 265                 270         


Ser Ser Val Ile Tyr Gly Lys Ile Leu Ser Ile Leu Ser Glu Leu Arg 
        275                 280                 285             


Thr Leu Gly Met Gln Asn Ser Asn Met Cys Ile Ser Leu Lys Leu Lys 
    290                 295                 300                 


Asn Arg Lys Leu Pro Pro Phe Leu Glu Glu Ile Trp Asp Val Ala Asp 
305                 310                 315                 320 


Met Ser His Thr Gln Pro Pro Pro Ile Leu Glu Ser Pro Thr Asn Leu 
                325                 330                 335     


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer junction amino acids

<400>  215

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer junction amino acids

<400>  216

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  217
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer junction amino acids

<400>  217

Gly Gly Gly Gly Ser 
1               5   


