                         SEQUENCE LISTING

<110>  Davoodi, Jamshid
       Davoodi, Mohammed M
 
<120>  COMPOSITIONS AND METHODS FOR PEPTIDE PRODUCTION

<130>  670011.32249

<160>  202   

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  Any one or all of the amino acids 1-2 may may be absent or 
       present

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Arg or Lys

<400>  1

Xaa Xaa Xaa Xaa 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  Any one or all of amino acids 1-2 may be absent or present

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<400>  2

Xaa Xaa Xaa Arg 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  Any or all of amino acids 1-2 may be absent or present

<400>  3

Xaa Xaa Arg Arg 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  Any of all of amino acids 1-2 may be absent or present

<400>  4

Xaa Xaa Lys Arg 
1               


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Gly, Ser, or Ala

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Arg or Lys

<400>  5

Xaa Xaa Xaa Xaa 
1               


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly, Ser, or Ala

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Gly, Ser, or Ala

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Arg or Lys

<400>  6

Xaa Xaa Xaa Xaa 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Gly or Ser

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Arg or Lys

<400>  7

Xaa Xaa Xaa Xaa 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly or Ser

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Gly or Ser

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Arg or Lys

<400>  8

Xaa Xaa Xaa Xaa 
1               


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be either present or absent

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Gly, Ser, or Ala

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<400>  9

Xaa Xaa Xaa Arg 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly, Ser, or Ala

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Gly, Ser, or Ala

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<400>  10

Xaa Xaa Xaa Arg 
1               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 is either present or absent

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Gly or Ser

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<400>  11

Xaa Xaa Xaa Arg 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly or Ser

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Gly or Ser

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<400>  12

Xaa Xaa Xaa Arg 
1               


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Arg or Lys

<400>  13

Arg Xaa Xaa Xaa 
1               


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<400>  14

Arg Xaa Xaa Arg 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Arg Xaa Arg Arg 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Arg Xaa Lys Arg 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<400>  17

Xaa Xaa Xaa Arg 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Arg or Lys

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<400>  18

Arg Xaa Xaa Arg 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  19

Arg Arg Arg Arg 
1               


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  20

Arg Lys Arg Arg 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  21

Arg Arg Lys Arg 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  22

Arg Lys Lys Arg 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  23

Lys Arg Arg Arg 
1               


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  24

Lys Lys Arg Arg 
1               


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  25

Lys Arg Lys Arg 
1               


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  26

Lys Lys Lys Arg 
1               


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg or Lys

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Arg or Lys

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg or Lys

<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is Arg or Lys

<400>  28

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg or Lys

<220>
<221>  misc_feature
<222>  (2)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Arg or Lys

<400>  29

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Tyr, Phe, Trp, Asp, Ile, Leu, Thr, or Val

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Glu, Asp, or Val

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Asp, Arg, or Lys

<400>  30

Xaa Xaa Xaa Xaa 
1               


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  31

Asp Asp Asp Asp Lys 
1               5   


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Tyr, Phe, Trp, Asp, Ile, Leu, Thr, or Val

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Glu or Val

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Xaa Xaa Xaa Asp 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Asp Glu Xaa Asp 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  34

Asp Glu Val Asp 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Tyr, Phe, or Trp

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Xaa Val Xaa Asp 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Tyr Val Xaa Asp 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Phe Val Xaa Asp 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

Trp Val Xaa Asp 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Ile, Leu, Thr, or Val

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  39

Xaa Glu Xaa Asp 
1               


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  40

Ile Glu Xaa Asp 
1               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Leu Glu Xaa Asp 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Thr or Val

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Xaa Glu Xaa Asp 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Glu or Asp

<400>  43

Ile Xaa Gly Arg 
1               


<210>  44
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  44

Ile Glu Gly Arg 
1               


<210>  45
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site

<400>  45

Ile Asp Gly Arg 
1               


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NTCB cleavage sequence


<220>
<221>  VARIANT
<222>  (2)..(4)
<223>  Any of amino acids 2-4 may be absent or present

<400>  46

Cys Xaa Xaa Xaa 
1               


<210>  47
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NTCB cleavage sequence


<220>
<221>  VARIANT
<222>  (3)..(4)
<223>  Any of amino acids 3-4 may be present or absent

<400>  47

Cys Gly Xaa Xaa 
1               


<210>  48
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NTCB cleavage sequence

<400>  48

Cys Gly Asp Glu 
1               


<210>  49
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pd2+ cleavage sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Pro or Gly

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is His or Met

<220>
<221>  VARIANT
<222>  (3)..(4)
<223>  Any of amino acids 3-4 may be absent or present

<400>  49

Xaa Xaa Xaa Xaa 
1               


<210>  50
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pd2+ cleavage sequence


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is His or Met

<220>
<221>  VARIANT
<222>  (3)..(4)
<223>  Any of amino acids 3-4 may be absent or present

<400>  50

Pro Xaa Xaa Xaa 
1               


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pd2+ cleavage sequence


<220>
<221>  VARIANT
<222>  (3)..(4)
<223>  Any of amino acids 3-4 may be absent or present

<400>  51

Pro His Xaa Xaa 
1               


<210>  52
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pd2+ cleavage sequence


<220>
<221>  VARIANT
<222>  (3)..(4)
<223>  Any of amino acids 3-4 may be absent or present

<400>  52

Pro Met Xaa Xaa 
1               


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ni2+ cleavage sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Ser or Thr

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Xaa Xaa His Xaa 
1               


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ni2+ cleavage sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  54

Ser Xaa His Xaa 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ni2+ cleavage sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Ser of Thr

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Arg, Trp, Phe, Ile, Leu, Met, or Val

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Arg, Trp, Phe, Ile, Leu, Met, or Val

<400>  55

Xaa Xaa His Xaa 
1               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ni2+ cleavage sequence

<400>  56

Ser Arg His Trp 
1               


<210>  57
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  57

Xaa Pro Ser Xaa 
1               


<210>  58
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  58

Xaa Pro Gly Xaa 
1               


<210>  59
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  59

Xaa Ala Ser Xaa 
1               


<210>  60
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  60

Xaa Ala Gly Xaa 
1               


<210>  61
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  61

Xaa Gly Gly Xaa 
1               


<210>  62
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  62

Xaa Gly Ser Xaa 
1               


<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  63

Xaa Lys Ser Xaa 
1               


<210>  64
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  64

Xaa Lys Gly Xaa 
1               


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 is absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 is absent or present

<400>  65

Xaa Glu Ser Xaa 
1               


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 is absent or present

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 is absent or present

<400>  66

Xaa Glu Gly Xaa 
1               


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  67

Gly Gly Gly Gly Ser 
1               5   


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Ser or Gly

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  68

Xaa Pro Xaa Xaa 
1               


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Ser or Gly

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  69

Pro Pro Xaa Xaa 
1               


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Ser or Gly

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  70

Pro Xaa Xaa Xaa 
1               


<210>  71
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  Any of amino acids 1-2 may be absent or present

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Ser or Gly

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  71

Xaa Xaa Xaa Xaa 
1               


<210>  72
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Ser or Gly

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 is absent or present

<400>  72

Pro Pro Xaa Xaa 
1               


<210>  73
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may be absent or present

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Ala, Lys, or Glu

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Ser or Gly

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may be absent or present

<400>  73

Xaa Xaa Xaa Xaa 
1               


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  74

Gly His His His His His His 
1               5           


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  75

Glu Ala Ala Ala Lys Ala 
1               5       


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  76

Ala Glu Ala Ala Ala Lys 
1               5       


<210>  77
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  77

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  78
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  78

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Phe or Gly

<400>  79

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Xaa 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  80

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  81

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Gly 
1               5                   10          


<210>  82
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  82

Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
1               5                   10                  15      


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln 
            20                  25                  30      


<210>  83
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  83

Gly Ala Gly Ala Gly Ala Met Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp 
            20                  25      


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon peptide

<400>  84

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  85
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exenatide peptide

<400>  85

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  86
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sermorelin peptide

<400>  86

Tyr Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln 
            20                  25                  30  


<210>  87
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nesiritide peptide

<400>  87

Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp 
1               5                   10                  15      


Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            20                  25                  30          


<210>  88
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Teduglutide peptide

<400>  88

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  89
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [Cys(Acm)20,31] Epidermal Growth Factor peptide

<400>  89

Cys Met His Ile Glu Ser Leu Asp Ser Tyr Thr Cys 
1               5                   10          


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T1 peptide

<400>  90

Met Ser Arg Pro Ala Cys Pro Asn Arg Lys Tyr Gly 
1               5                   10          


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTP-binding Protein Fragment, Galpha

<400>  91

Cys Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Lys 
1               5                   10                  15      


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-selectin peptide

<400>  92

Cys Gln Lys Leu Asp Lys Ser Phe Ser Met Ile Lys 
1               5                   10          


<210>  93
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Standard 1

<400>  93

Cys Pro Asp Phe Gly His Ile Ala Met Glu Leu Ser Val Arg Thr Trp 
1               5                   10                  15      


Lys Tyr 
        


<210>  94
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTH (1-39) (Acthar)

<400>  94

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Asp Gly Ala Glu Asp Gln Leu Ala 
            20                  25                  30          


Glu Ala Phe Pro Leu Glu Phe 
        35                  


<210>  95
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTH (1-24)

<400>  95

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro 
            20                  


<210>  96
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lepirudin

<400>  96

Leu Val Tyr Thr Asp Cys Thr Glu Ser Gly Gln Asn Leu Cys Leu Cys 
1               5                   10                  15      


Glu Gly Ser Asn Val Cys Gly Gln Gly Asn Lys Cys Ile Leu Gly Ser 
            20                  25                  30          


Asp Gly Glu Lys Asn Gln Cys Val Thr Gly Glu Gly Thr Pro Lys Pro 
        35                  40                  45              


Gln Ser His Asn Asp Gly Asp Phe Glu Glu Ile Pro Glu Glu Tyr Leu 
    50                  55                  60                  


Gln 
65  


<210>  97
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Calcitonin

<400>  97

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Gly Thr Pro 
            20                  25                  30          


<210>  98
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Somatostatin

<400>  98

Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
1               5                   10                  


<210>  99
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Megainin 1

<400>  99

Gly Ile Gly Lys Phe Leu His Ser Ala Gly Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Lys Ser 
            20              


<210>  100
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Megainin 2

<400>  100

Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser 
            20              


<210>  101
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Corticotropin

<400>  101

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro Asp Gly Ala Glu Asp Gln Leu Ala 
            20                  25                  30          


Glu Ala Phe Pro Leu Glu Phe 
        35                  


<210>  102
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Teriparatide

<400>  102

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  103
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tesamorelin

<400>  103

Tyr Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly 
            20                  25                  30          


Glu Ser Asn Gln Glu Arg Gly Ala Arg Ala Arg Leu 
        35                  40                  


<210>  104
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aprotinin

<400>  104

Arg Pro Asp Phe Cys Leu Glu Pro Pro Tyr Thr Gly Pro Cys Lys Ala 
1               5                   10                  15      


Arg Ile Ile Arg Tyr Phe Tyr Asn Ala Lys Ala Gly Leu Cys Gln Thr 
            20                  25                  30          


Phe Val Tyr Gly Gly Cys Arg Ala Lys Arg Asn Asn Phe Lys Ser Ala 
        35                  40                  45              


Glu Asp Cys Met Arg Thr Cys Gly Gly Ala 
    50                  55              


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vasopressin

<400>  105

Cys Tyr Phe Gln Asn Cys Pro Arg Gly 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oxytocin

<400>  106

Cys Tyr Ile Gln Asn Cys Pro Leu Gly 
1               5                   


<210>  107
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin Chain A

<400>  107

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  108
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin Chain B

<400>  108

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  109
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pramlinitide

<400>  109

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  110
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Liraglutide

<400>  110

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


<210>  111
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2 alpha1 Helix peptide

<400>  111

Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      


Glu Asp Leu Phe Tyr Gln Ser 
            20              


<210>  112
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sinapultide

<400>  112

Lys Leu Leu Leu Leu Lys Leu Leu Leu Leu Lys Leu Leu Leu Leu Lys 
1               5                   10                  15      


Leu Leu Leu Leu 
            20  


<210>  113
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thymalfasin

<400>  113

Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr Lys Asp Leu 
1               5                   10                  15      


Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn 
            20                  25              


<210>  114
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Apolipoprotein B synthetic peptide

<400>  114

Lys Tyr Tyr Glu Leu Glu Glu Lys Ile Val Ser Leu Ile Lys Asn Leu 
1               5                   10                  15      


Leu Val Ala Leu Lys 
            20      


<210>  115
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Galanin

<400>  115

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val 
1               5                   10                  15      


Gly Asn His Arg Ser Phe Ser Asp Lys Asn Gly Leu Thr Ser 
            20                  25                  30  


<210>  116
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tau Peptide (45-73) (Exon 2/Insert 1 domain)

<400>  116

Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly 
1               5                   10                  15      


Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu 
            20                  25                  


<210>  117
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bivalirudin

<400>  117

Phe Pro Arg Pro Gly Gly Gly Gly Asn Gly Asp Phe Glu Glu Ile Pro 
1               5                   10                  15      


Glu Glu Tyr Leu 
            20  


<210>  118
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enfuviritide

<400>  118

Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 
1               5                   10                  15      


Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 
            20                  25                  30          


Trp Asn Trp Phe 
        35      


<210>  119
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretin

<400>  119

His Ser Asp Gly Thr Phe Thr Ser Glu Leu Ser Arg Leu Arg Asp Ser 
1               5                   10                  15      


Ala Arg Leu Gln Arg Leu Leu Gln Gly Leu Val 
            20                  25          


<210>  120
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gramicidin D


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  120

Val Gly Ala Leu Ala Val Val Val Trp Leu Trp Leu Trp Leu Trp Xaa 
1               5                   10                  15      


<210>  121
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glatiramer

<400>  121

Glu Ala Tyr Lys Ala Ala Glu Lys Ala Tyr Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Lys Ala Lys Ala Glu Lys Lys Ala Ala Tyr Ala Lys 
            20                  25                  30          


Ala Lys Ala Ala Lys Tyr Glu Lys Lys Ala Lys Lys Ala Ala Ala Glu 
        35                  40                  45              


Tyr Lys Lys Lys 
    50          


<210>  122
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thioredoxin tag

<400>  122

Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys 
1               5                   10                  15      


Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro 
            20                  25                  30          


Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly 
        35                  40                  45              


Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys 
    50                  55                  60                  


Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly Ser Gly His Met His 
65                  70                  75                  80  


His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser Gly Met Lys 
                85                  90                  95      


Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Pro Asp 
            100                 105                 110         


Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Asp Ile Gly Ser 
        115                 120                 125         


<210>  123
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His6 tag

<400>  123

His His His His His His 
1               5       


<210>  124
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  124

Met His His His His His His Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp 
            20                  25      


<210>  125
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  125

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Cys Gly Asp 
            20                  25                  30          


Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr 
        35                  40                  45              


Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
    50                  55                  60                  


Cys Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr 
65                  70                  75                  80  


Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu 
                85                  90                  95      


Met Asn Thr Cys Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr 
            100                 105                 110         


Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val 
        115                 120                 125             


Gln Trp Leu Met Asn Thr 
    130                 


<210>  126
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  126

Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys 
1               5                   10                  15      


Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro 
            20                  25                  30          


Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly 
        35                  40                  45              


Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys 
    50                  55                  60                  


Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly Ser Gly His Met His 
65                  70                  75                  80  


His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser Gly Met Lys 
                85                  90                  95      


Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Pro Asp 
            100                 105                 110         


Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Asp Ile Gly Ser Gly 
        115                 120                 125             


Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    130                 135                 140                 


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
145                 150                 155                 160 


Thr Cys Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp 
                165                 170                 175     


Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp 
            180                 185                 190         


Leu Met Asn Thr Cys Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe 
        195                 200                 205             


Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe 
    210                 215                 220                 


Val Gln Trp Leu Met Asn Thr Cys Gly Asp Glu Val Asp His Ser Gln 
225                 230                 235                 240 


Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala 
                245                 250                 255     


Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            260                 265     


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and protease recognition site

<400>  127

Gly Asp Glu Val Asp 
1               5   


<210>  128
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and protease recognition site

<400>  128

Cys Gly Asp Glu Val Asp 
1               5       


<210>  129
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  129

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Pro His Gly 
            20                  25                  30          


Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser 
        35                  40                  45              


Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met 
    50                  55                  60                  


Asn Thr Pro His Gly Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe 
65                  70                  75                  80  


Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe 
                85                  90                  95      


Val Gln Trp Leu Met Asn Thr Pro His Gly Gly Asp Glu Val Asp His 
            100                 105                 110         


Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg 
        115                 120                 125             


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
    130                 135                 140 


<210>  130
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  130

Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys 
1               5                   10                  15      


Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro 
            20                  25                  30          


Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly 
        35                  40                  45              


Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys 
    50                  55                  60                  


Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly Ser Gly His Met His 
65                  70                  75                  80  


His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser Gly Met Lys 
                85                  90                  95      


Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Pro Asp 
            100                 105                 110         


Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Asp Ile Gly Ser Gly 
        115                 120                 125             


Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    130                 135                 140                 


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
145                 150                 155                 160 


Thr Pro His Gly Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr 
                165                 170                 175     


Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val 
            180                 185                 190         


Gln Trp Leu Met Asn Thr Pro His Gly Gly Asp Glu Val Asp His Ser 
        195                 200                 205             


Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg 
    210                 215                 220                 


Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Pro His Gly Gly Asp 
225                 230                 235                 240 


Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr 
                245                 250                 255     


Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            260                 265                 270         


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and chemical cleavage site

<400>  131

Pro His Gly Gly Asp Glu Val Asp 
1               5               


<210>  132
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  132

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Ser Arg His 
            20                  25                  30          


Trp Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr 
        35                  40                  45              


Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu 
    50                  55                  60                  


Met Asn Thr Ser Arg His Trp Gly Asp Glu Val Asp His Ser Gln Gly 
65                  70                  75                  80  


Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln 
                85                  90                  95      


Asp Phe Val Gln Trp Leu Met Asn Thr Ser Arg His Trp Gly Asp Glu 
            100                 105                 110         


Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
        115                 120                 125             


Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
    130                 135                 140             


<210>  133
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  133

Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys 
1               5                   10                  15      


Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro 
            20                  25                  30          


Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly 
        35                  40                  45              


Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys 
    50                  55                  60                  


Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly Ser Gly His Met His 
65                  70                  75                  80  


His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser Gly Met Lys 
                85                  90                  95      


Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Pro Asp 
            100                 105                 110         


Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Asp Ile Gly Ser Gly 
        115                 120                 125             


Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    130                 135                 140                 


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
145                 150                 155                 160 


Thr Ser Arg His Trp Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe 
                165                 170                 175     


Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe 
            180                 185                 190         


Val Gln Trp Leu Met Asn Thr Ser Arg His Trp Gly Asp Glu Val Asp 
        195                 200                 205             


His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
    210                 215                 220                 


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Ser Arg His 
225                 230                 235                 240 


Trp Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr 
                245                 250                 255     


Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu 
            260                 265                 270         


Met Asn Thr 
        275 


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and chemical cleavage site

<400>  134

Ser Arg His Trp Gly Asp Glu Val Asp 
1               5                   


<210>  135
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  135

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Arg Arg Gly Ser Lys Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
        35                  40                  45              


Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp 
    50                  55                  60                  


Leu Val Arg Gly Arg Gly Arg Arg Gly Ser Arg Arg His Ala Glu Gly 
65                  70                  75                  80  


Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys 
                85                  90                  95      


Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg Arg Gly Ser 
            100                 105                 110         


Lys Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 
        115                 120                 125             


Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly 
    130                 135                 140                 


Arg Gly 
145     


<210>  136
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  136

Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys 
1               5                   10                  15      


Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro 
            20                  25                  30          


Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly 
        35                  40                  45              


Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys 
    50                  55                  60                  


Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly Ser Gly His Met His 
65                  70                  75                  80  


His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser Gly Met Lys 
                85                  90                  95      


Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Pro Asp 
            100                 105                 110         


Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Asp Ile Gly Ser Gly 
        115                 120                 125             


Arg Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 
    130                 135                 140                 


Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly 
145                 150                 155                 160 


Arg Gly Arg Arg Gly Ser Lys Arg His Ala Glu Gly Thr Phe Thr Ser 
                165                 170                 175     


Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile 
            180                 185                 190         


Ala Trp Leu Val Arg Gly Arg Gly Arg Arg Gly Ser Arg Arg His Ala 
        195                 200                 205             


Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala 
    210                 215                 220                 


Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg Arg 
225                 230                 235                 240 


Gly Ser Lys Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 
                245                 250                 255     


Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val 
            260                 265                 270         


Arg Gly Arg Gly 
        275     


<210>  137
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and protease recognition site

<400>  137

Arg Arg Gly Ser Lys Arg 
1               5       


<210>  138
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  138

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Pro His Gly Gly Asp Glu Val Asp His Ala Glu Gly Thr Phe Thr Ser 
        35                  40                  45              


Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile 
    50                  55                  60                  


Ala Trp Leu Val Arg Gly Arg Gly Pro His Gly Gly Asp Glu Val Asp 
65                  70                  75                  80  


His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
                85                  90                  95      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            100                 105                 110         


Pro His Gly Gly Asp Glu Val Asp His Ala Glu Gly Thr Phe Thr Ser 
        115                 120                 125             


Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile 
    130                 135                 140                 


Ala Trp Leu Val Arg Gly Arg Gly 
145                 150         


<210>  139
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  139

Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys 
1               5                   10                  15      


Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro 
            20                  25                  30          


Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly 
        35                  40                  45              


Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys 
    50                  55                  60                  


Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly Ser Gly His Met His 
65                  70                  75                  80  


His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser Gly Met Lys 
                85                  90                  95      


Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Pro Asp 
            100                 105                 110         


Leu Gly Thr Asp Asp Asp Asp Lys Ala Met Ala Asp Ile Gly Ser Gly 
        115                 120                 125             


Asp Glu Val Asp His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 
    130                 135                 140                 


Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val 
145                 150                 155                 160 


Arg Gly Arg Gly Pro His Gly Gly Asp Glu Val Asp His Ala Glu Gly 
                165                 170                 175     


Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys 
            180                 185                 190         


Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Pro His Gly Gly 
        195                 200                 205             


Asp Glu Val Asp His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 
    210                 215                 220                 


Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val 
225                 230                 235                 240 


Arg Gly Arg Gly Pro His Gly Gly Asp Glu Val Asp His Ala Glu Gly 
                245                 250                 255     


Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys 
            260                 265                 270         


Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
        275                 280                 


<210>  140
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  140

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Pro His Gly Gly Asp Glu Val Asp 
        35                  40  


<210>  141
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  141

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Ser Arg 
            20                  25                  30          


His Trp Gly Asp Glu Val Asp Phe Val Asn Gln His Leu Cys Gly Ser 
        35                  40                  45              


His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe 
    50                  55                  60                  


Tyr Thr Pro Lys Thr Ser Arg His Trp Gly Asp Glu Val Asp Gly Ile 
65                  70                  75                  80  


Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn 
                85                  90                  95      


Tyr Cys Asn Ser Arg His Trp Gly Asp Glu Val Asp Gly Ile Val Glu 
            100                 105                 110         


Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
        115                 120                 125             


Asn 
    


<210>  142
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  142

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Gly Ser Lys Arg Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val 
        35                  40                  45              


Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro 
    50                  55                  60                  


Lys Thr Arg Arg Gly Ser Arg Arg Gly Ile Val Glu Gln Cys Cys Thr 
65                  70                  75                  80  


Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg Arg Gly 
                85                  90                  95      


Ser Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu 
            100                 105                 110         


Tyr Gln Leu Glu Asn Tyr Cys Asn 
        115                 120 


<210>  143
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  143

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


<210>  144
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  144

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn Arg Arg 
            20              


<210>  145
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  145

Gly Asp Glu Val Asp His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 
1               5                   10                  15      


Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Arg Gly Arg Gly Pro Gly Gly Asp Glu Val Asp His Ala Glu Gly 
        35                  40                  45              


Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys 
    50                  55                  60                  


Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Pro Gly Gly Asp 
65                  70                  75                  80  


Glu Val Asp His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 
                85                  90                  95      


Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg 
            100                 105                 110         


Gly Arg Gly Pro Gly Gly Asp Glu Val Asp His Ala Glu Gly Thr Phe 
        115                 120                 125             


Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu 
    130                 135                 140                 


Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
145                 150                 


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and protease recognition site

<400>  146

Pro Gly Gly Asp Glu Val Asp 
1               5           


<210>  147
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  147

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Pro Gly Gly Asp Glu Val Asp 
        35                  


<210>  148
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  148

Arg Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 
1               5                   10                  15      


Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly 
            20                  25                  30          


Arg Gly Pro Gly Gly Arg Arg His Ala Glu Gly Thr Phe Thr Ser Asp 
        35                  40                  45              


Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala 
    50                  55                  60                  


Trp Leu Val Arg Gly Arg Gly Pro Gly Gly Lys Arg His Ala Glu Gly 
65                  70                  75                  80  


Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys 
                85                  90                  95      


Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Pro Gly Gly Arg 
            100                 105                 110         


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
        115                 120                 125             


Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 
    130                 135                 140                 


Gly 
145 


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and protease recognition site

<400>  149

Pro Gly Gly Arg Arg 
1               5   


<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and protease recognition site

<400>  150

Pro Gly Gly Lys Arg 
1               5   


<210>  151
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  151

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Pro Gly Gly Lys Arg 
        35          


<210>  152
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  152

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Pro Gly Gly Arg Arg 
        35          


<210>  153
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  153

Asp Asp Asp Asp Lys His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 
1               5                   10                  15      


Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Arg Gly Arg Gly Pro Gly Gly Asp Asp Asp Asp Lys His Ala Glu 
        35                  40                  45              


Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala 
    50                  55                  60                  


Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Pro Gly Gly 
65                  70                  75                  80  


Asp Asp Asp Asp Lys His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 
                85                  90                  95      


Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu 
            100                 105                 110         


Val Arg Gly Arg Gly Pro Gly Gly Asp Asp Asp Asp Lys His Ala Glu 
        115                 120                 125             


Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala 
    130                 135                 140                 


Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
145                 150                 155         


<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and protease recognition site

<400>  154

Pro Gly Gly Asp Asp Asp Asp Lys 
1               5               


<210>  155
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  155

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Pro Gly Gly Asp Asp Asp Asp Lys 
        35                  40  


<210>  156
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  156

Met His His His His His His Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val 
            20                  25                  30          


Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala 
    50                  55                  60                  


Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala 
65                  70                  75                  80  


Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly 
                85                  90                  95      


Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
            100                 105                 110         


Asn Tyr Cys Asn Arg Arg Gly Ala Gly Ala Gly Ala Met Ala Leu Trp 
        115                 120                 125             


Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp 
    130                 135                 140                 


Asp Glu Val Asp Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val 
145                 150                 155                 160 


Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro 
                165                 170                 175     


Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu 
            180                 185                 190         


Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly 
        195                 200                 205             


Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
    210                 215                 220                 


Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
225                 230                 


<210>  157
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  157

Met His His His His His His Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val 
            20                  25                  30          


Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala 
    50                  55                  60                  


Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala 
65                  70                  75                  80  


Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly 
                85                  90                  95      


Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
            100                 105                 110         


Asn Tyr Cys Asn Arg Arg Gly Ala Gly Ala Gly Ala Met Ala Leu Trp 
        115                 120                 125             


Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp 
    130                 135                 140                 


Asp Glu Val Asp Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val 
145                 150                 155                 160 


Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro 
                165                 170                 175     


Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu 
            180                 185                 190         


Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly 
        195                 200                 205             


Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
    210                 215                 220                 


Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg Arg Gly Ala Gly Ala 
225                 230                 235                 240 


Gly Ala Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu 
                245                 250                 255     


Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val Asn Gln His Leu 
            260                 265                 270         


Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg 
        275                 280                 285             


Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln 
    290                 295                 300                 


Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln 
305                 310                 315                 320 


Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln 
                325                 330                 335     


Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            340                 345                 350         


<210>  158
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  158

Met His His His His His His Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val 
            20                  25                  30          


Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala 
    50                  55                  60                  


Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala 
65                  70                  75                  80  


Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly 
                85                  90                  95      


Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
            100                 105                 110         


Asn Tyr Cys Asn Arg Arg Gly Ala Gly Ala Gly Ala Met Ala Leu Trp 
        115                 120                 125             


Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp 
    130                 135                 140                 


Asp Glu Val Asp Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val 
145                 150                 155                 160 


Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro 
                165                 170                 175     


Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu 
            180                 185                 190         


Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly 
        195                 200                 205             


Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
    210                 215                 220                 


Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg Arg Gly Ala Gly Ala 
225                 230                 235                 240 


Gly Ala Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu 
                245                 250                 255     


Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val Asn Gln His Leu 
            260                 265                 270         


Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg 
        275                 280                 285             


Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln 
    290                 295                 300                 


Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln 
305                 310                 315                 320 


Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln 
                325                 330                 335     


Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            340                 345                 350         


Arg Arg Gly Ala Gly Ala Gly Ala Met Ala Leu Trp Met Arg Leu Leu 
        355                 360                 365             


Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp 
    370                 375                 380                 


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
385                 390                 395                 400 


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
                405                 410                 415     


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
            420                 425                 430         


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
        435                 440                 445             


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
    450                 455                 460                 


Leu Glu Asn Tyr Cys Asn 
465                 470 


<210>  159
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  159

Met His His His His His His Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val 
            20                  25                  30          


Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala 
    50                  55                  60                  


Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala 
65                  70                  75                  80  


Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly 
                85                  90                  95      


Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
            100                 105                 110         


Asn Tyr Cys Asn Arg Arg Gly Ala Gly Ala Gly Ala Met Ala Leu Trp 
        115                 120                 125             


Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp 
    130                 135                 140                 


Asp Glu Val Asp Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val 
145                 150                 155                 160 


Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro 
                165                 170                 175     


Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu 
            180                 185                 190         


Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly 
        195                 200                 205             


Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
    210                 215                 220                 


Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg Arg Gly Ala Gly Ala 
225                 230                 235                 240 


Gly Ala Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu 
                245                 250                 255     


Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val Asn Gln His Leu 
            260                 265                 270         


Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg 
        275                 280                 285             


Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln 
    290                 295                 300                 


Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln 
305                 310                 315                 320 


Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln 
                325                 330                 335     


Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            340                 345                 350         


Arg Arg Gly Ala Gly Ala Gly Ala Met Ala Leu Trp Met Arg Leu Leu 
        355                 360                 365             


Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp 
    370                 375                 380                 


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
385                 390                 395                 400 


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
                405                 410                 415     


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
            420                 425                 430         


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
        435                 440                 445             


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
    450                 455                 460                 


Leu Glu Asn Tyr Cys Asn Arg Arg Gly Ala Gly Ala Gly Ala Met Ala 
465                 470                 475                 480 


Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly 
                485                 490                 495     


Pro Asp Asp Glu Val Asp Phe Val Asn Gln His Leu Cys Gly Ser His 
            500                 505                 510         


Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr 
        515                 520                 525             


Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val 
    530                 535                 540                 


Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu 
545                 550                 555                 560 


Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser 
                565                 570                 575     


Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg Arg Gly Ala 
            580                 585                 590         


Gly Ala Gly Ala Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala 
        595                 600                 605             


Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val Asn Gln 
    610                 615                 620                 


His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
625                 630                 635                 640 


Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp 
                645                 650                 655     


Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser 
            660                 665                 670         


Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val 
        675                 680                 685             


Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr 
    690                 695                 700                 


Cys Asn Arg Arg Gly Ala Gly Ala Gly Ala Met Ala Leu Trp Met Arg 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu 
                725                 730                 735     


Val Asp Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala 
            740                 745                 750         


Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
        755                 760                 765             


Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly 
    770                 775                 780                 


Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu 
785                 790                 795                 800 


Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu 
                805                 810                 815     


Tyr Gln Leu Glu Asn Tyr Cys Asn 
            820                 


<210>  160
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  160

Met His His His His His His Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val 
            20                  25                  30          


Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
    50                  55                  60          


<210>  161
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  161

Gly Ala Gly Ala Gly Ala Met Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val 
            20                  25                  30          


Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
    50                  55                  60          


<210>  162
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  162

Met His His His His His His Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val 
            20                  25                  30          


Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
    50                  55                  60  


<210>  163
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  163

Gly Ala Gly Ala Gly Ala Met Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Asp Glu Val Asp Phe Val 
            20                  25                  30          


Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
    50                  55                  60  


<210>  164
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  164

Gly Arg Arg His His His His His His Asp Glu Val Asp Phe Val Asn 
1               5                   10                  15      


Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys 
            20                  25                  30          


Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Gly His His 
        35                  40                  45              


His His His His Asp Glu Val Asp Phe Val Asn Gln His Leu Cys Gly 
    50                  55                  60                  


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Phe Tyr Thr Pro Lys Thr Arg Arg His His His His His His Asp Glu 
                85                  90                  95      


Val Asp Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr 
            100                 105                 110         


Gln Leu Glu Asn Tyr Cys Asn Arg Arg Gly His His His His His His 
        115                 120                 125             


Asp Glu Val Asp Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser 
    130                 135                 140                 


Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
145                 150             


<210>  165
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  165

Gly Arg Arg His His His His His His Asp Glu Val Asp Gly Ile Val 
1               5                   10                  15      


Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr 
            20                  25                  30          


Cys Asn Arg Arg Gly His His His His His His Asp Glu Val Asp Gly 
        35                  40                  45              


Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
    50                  55                  60                  


Asn Tyr Cys Asn Arg Arg His His His His His His Asp Glu Val Asp 
65                  70                  75                  80  


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
                85                  90                  95      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            100                 105                 110         


Gly His His His His His His Asp Glu Val Asp Phe Val Asn Gln His 
        115                 120                 125             


Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu 
    130                 135                 140                 


Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
145                 150             


<210>  166
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  166

Gly His His His His His His Asp Glu Val Asp Phe Val Asn Gln His 
1               5                   10                  15      


Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu 
            20                  25                  30          


Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
        35                  40              


<210>  167
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  167

His His His His His His Asp Glu Val Asp Gly Ile Val Glu Gln Cys 
1               5                   10                  15      


Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn Arg 
            20                  25                  30          


Arg 
    


<210>  168
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  168

Gly His His His His His His Asp Glu Val Asp Gly Ile Val Glu Gln 
1               5                   10                  15      


Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            20                  25                  30          


Arg Arg 
        


<210>  169
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  169

His His His His His His Asp Glu Val Asp Phe Val Asn Gln His Leu 
1               5                   10                  15      


Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg 
            20                  25                  30          


Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
        35                  40          


<210>  170
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  170

Gly His His His His His His Asp Glu Val Asp Phe Val Asn Gln His 
1               5                   10                  15      


Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu 
            20                  25                  30          


Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
        35                  40      


<210>  171
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  171

His His His His His His Asp Glu Val Asp Gly Ile Val Glu Gln Cys 
1               5                   10                  15      


Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            20                  25                  30      


<210>  172
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  172

Gly His His His His His His Asp Glu Val Asp Gly Ile Val Glu Gln 
1               5                   10                  15      


Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            20                  25                  30          


<210>  173
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  173

His His His His His His Asp Glu Val Asp Phe Val Asn Gln His Leu 
1               5                   10                  15      


Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg 
            20                  25                  30          


Gly Phe Phe Tyr Thr Pro Lys Thr 
        35                  40  


<210>  174
<211>  6286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  174
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat      600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg      720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg      960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg     3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc     3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg     3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca     3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag     3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt     3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc     3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc     3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct     3900

tcggtatcgt cgtatcccac taccgagatg tccgcaccaa cgcgcagccc ggactcggta     3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg     4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct     4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga     4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc     4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg     4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct     4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt     4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc     4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc     4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc     4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact     4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga     4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc     4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg     4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag     4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat     5100

cgatctcgat cccgcgaaat taatacgact cactataggg gaattgtgag cggataacaa     5160

ttcccctcta gaaataattt tgtttaactt taagaaggag atatacatat gagcgataaa     5220

attattcacc tgactgacga cagttttgac acggatgtac tcaaagcgga cggggcgatc     5280

ctcgtcgatt tctgggcaga gtggtgcggt ccgtgcaaaa tgatcgcccc gattctggat     5340

gaaatcgctg acgaatatca gggcaaactg accgttgcaa aactgaacat cgatcaaaac     5400

cctggcactg cgccgaaata tggcatccgt ggtatcccga ctctgctgct gttcaaaaac     5460

ggtgaagtgg cggcaaccaa agtgggtgca ctgtctaaag gtcagttgaa agagttcctc     5520

gacgctaacc tggccggttc tggttctggc catatgcacc atcatcatca tcattcttct     5580

ggtctggtgc cacgcggttc tggtatgaaa gaaaccgctg ctgctaaatt cgaacgccag     5640

cacatggaca gcccagatct gggtaccgac gacgacgaca aggccatggc tgatatcgga     5700

tccggtgacg aagtggacca tagccaaggc acctttacca gcgactatag caagtacctg     5760

gatagccgcc gtgcgcaaga ttttgttcaa tggctgatga acacctgcgg tgacgaggtg     5820

gatcacagcc agggcacctt caccagcgac tacagcaagt atttagatag ccgtcgtgct     5880

caggactttg tgcaatggtt aatgaatacc tgcggtgacg aagttgatca cagccaaggc     5940

accttcacca gcgattacag caaatatctg gacagccgtc gtgcgcagga ttttgtgcaa     6000

tggcttatga atacctgcgg cgatgaggtt gaccatagcc agggtacctt taccagcgac     6060

tacagcaaat acctggatag ccgtcgtgcg caagacttcg ttcaatggct gatgaatacc     6120

taactcgagc accaccacca ccaccactga gatccggctg ctaacaaagc ccgaaaggaa     6180

gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa     6240

cgggtcttga ggggtttttt gctgaaagga ggaactatat ccggat                    6286


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(5)
<223>  Amino acids 1-5 may be absent or present

<220>
<221>  VARIANT
<222>  (7)..(9)
<223>  Any of all of amino acids 7-8 may be absent or present

<400>  175

Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa 
1               5                   


<210>  176
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  176

Pro Ile Val Xaa 
1               


<210>  177
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  177

Leu Gln Ser Xaa 
1               


<210>  178
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  178

Pro Gln Ile Xaa 
1               


<210>  179
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  179

Pro Ile Ser Xaa 
1               


<210>  180
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  180

Pro Val Gln Xaa 
1               


<210>  181
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  181

Pro Val Ala Xaa 
1               


<210>  182
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  182

Pro Ile Met Xaa 
1               


<210>  183
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  183

Pro Ile Gln Xaa 
1               


<210>  184
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  184

Pro Val Val Xaa 
1               


<210>  185
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  185

Pro Leu Arg Xaa 
1               


<210>  186
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acids 4 may may be absent or present

<400>  186

Pro Val Thr Xaa 
1               


<210>  187
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  187

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Asp Ile Gly Gly Ser Asp Glu Val Asp Ser Val Ser Glu Ile Gln 
                165                 170                 175     


Leu Met His Asn Leu Gly Lys His Leu Asn Ser Met Glu Arg Val Glu 
            180                 185                 190         


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe Ser Arg His Trp 
        195                 200                 205             


Ser Asp Glu Val Asp Ser Val Ser Glu Ile Gln Leu Met His Asn Leu 
    210                 215                 220                 


Gly Lys His Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys 
225                 230                 235                 240 


Leu Gln Asp Val His Asn Phe Ser Arg His Trp Ser Asp Glu Val Asp 
                245                 250                 255     


Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
            260                 265                 270         


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
        275                 280                 285             


Asn Phe Ser Arg His Trp Ser Asp Glu Val Asp Ser Val Ser Glu Ile 
    290                 295                 300                 


Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser Met Glu Arg Val 
305                 310                 315                 320 


Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe 
                325                 330             


<210>  188
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  188

Ser Asp Glu Val Asp Ser Val Ser Glu Ile Gln Leu Met His Asn Leu 
1               5                   10                  15      


Gly Lys His Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys 
            20                  25                  30          


Leu Gln Asp Val His Asn Phe Pro Ile Ser Asp Glu Val Asp Ser Val 
        35                  40                  45              


Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser Met 
    50                  55                  60                  


Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe 
65                  70                  75                  80  


Pro Ile Ser Asp Glu Val Asp Ser Val Ser Glu Ile Gln Leu Met His 
                85                  90                  95      


Asn Leu Gly Lys His Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg 
            100                 105                 110         


Lys Lys Leu Gln Asp Val His Asn Phe Pro Ile Ser Asp Glu Val Asp 
        115                 120                 125             


Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
    130                 135                 140                 


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
145                 150                 155                 160 


Asn Phe 
        


<210>  189
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  189

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Asp Ile Gly Ser Gly Asp Glu Val Asp Ser Val Ser Glu Ile Gln 
                165                 170                 175     


Leu Met His Asn Leu Gly Lys His Leu Asn Ser Met Glu Arg Val Glu 
            180                 185                 190         


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe Pro Ile Ser Asp 
        195                 200                 205             


Glu Val Asp Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys 
    210                 215                 220                 


His Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln 
225                 230                 235                 240 


Asp Val His Asn Phe Pro Ile Ser Asp Glu Val Asp Ser Val Ser Glu 
                245                 250                 255     


Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser Met Glu Arg 
            260                 265                 270         


Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe Pro Ile 
        275                 280                 285             


Ser Asp Glu Val Asp Ser Val Ser Glu Ile Gln Leu Met His Asn Leu 
    290                 295                 300                 


Gly Lys His Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys 
305                 310                 315                 320 


Leu Gln Asp Val His Asn Phe 
                325         


<210>  190
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  190

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Pro Ile Ser Asp Glu Val Asp 
        35                  40      


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide comprising linker and protease recognition site

<400>  191

Pro Ile Ser Asp Glu Val Asp 
1               5           


<210>  192
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate peptide

<400>  192

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Arg Arg 
        


<210>  193
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thioredoxin tag

<400>  193

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Asp Ile Gly Ser Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe 
                165                 170                 175     


Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe 
            180                 185                 190         


Val Gln Trp Leu Met Asn Thr Cys Gly Asp Glu Val Asp His Ser Gln 
        195                 200                 205             


Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala 
    210                 215                 220                 


Gln Asp Phe Val Gln Trp Leu Met Asn Thr Cys Gly Asp Glu Val Asp 
225                 230                 235                 240 


His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
                245                 250                 255     


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Cys Gly Asp 
            260                 265                 270         


Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr 
        275                 280                 285             


Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
    290                 295                 300                 


<210>  194
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  194

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Asp Ile Gly Ser Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe 
                165                 170                 175     


Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe 
            180                 185                 190         


Val Gln Trp Leu Met Asn Thr Pro His Gly Gly Asp Glu Val Asp His 
        195                 200                 205             


Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg 
    210                 215                 220                 


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Pro His Gly Gly 
225                 230                 235                 240 


Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
                245                 250                 255     


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
            260                 265                 270         


Thr Pro His Gly Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr 
        275                 280                 285             


Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val 
    290                 295                 300                 


Gln Trp Leu Met Asn Thr 
305                 310 


<210>  195
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  195

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Asp Ile Gly Ser Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe 
                165                 170                 175     


Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe 
            180                 185                 190         


Val Gln Trp Leu Met Asn Thr Ser Arg His Trp Gly Asp Glu Val Asp 
        195                 200                 205             


His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
    210                 215                 220                 


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Ser Arg His 
225                 230                 235                 240 


Trp Gly Asp Glu Val Asp His Ser Gln Gly Thr Phe Thr Ser Asp Tyr 
                245                 250                 255     


Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu 
            260                 265                 270         


Met Asn Thr Ser Arg His Trp Gly Asp Glu Val Asp His Ser Gln Gly 
        275                 280                 285             


Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln 
    290                 295                 300                 


Asp Phe Val Gln Trp Leu Met Asn Thr 
305                 310             


<210>  196
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  196

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Asp Ile Gly Ser Gly Arg Arg His Ala Glu Gly Thr Phe Thr Ser 
                165                 170                 175     


Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile 
            180                 185                 190         


Ala Trp Leu Val Arg Gly Arg Gly Arg Arg Gly Ser Lys Arg His Ala 
        195                 200                 205             


Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala 
    210                 215                 220                 


Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg Arg 
225                 230                 235                 240 


Gly Ser Arg Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 
                245                 250                 255     


Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val 
            260                 265                 270         


Arg Gly Arg Gly Arg Arg Gly Ser Lys Arg His Ala Glu Gly Thr Phe 
        275                 280                 285             


Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu 
    290                 295                 300                 


Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
305                 310                 


<210>  197
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  197

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Asp Ile Gly Ser Gly Asp Glu Val Asp His Ala Glu Gly Thr Phe 
                165                 170                 175     


Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu 
            180                 185                 190         


Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Pro His Gly Gly Asp Glu 
        195                 200                 205             


Val Asp His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 
    210                 215                 220                 


Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly 
225                 230                 235                 240 


Arg Gly Pro His Gly Gly Asp Glu Val Asp His Ala Glu Gly Thr Phe 
                245                 250                 255     


Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Glu 
            260                 265                 270         


Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Pro His Gly Gly Asp Glu 
        275                 280                 285             


Val Asp His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 
    290                 295                 300                 


Glu Gly Gln Ala Ala Lys Glu Glu Phe Ile Ala Trp Leu Val Arg Gly 
305                 310                 315                 320 


Arg Gly 
        


<210>  198
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Amino acid 1 may may be absent or present

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa  is Gly, Ala, Val, Leu, Ile, Phe, Met, or Trp.

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa  is Gly, Ala, Val, Leu, Ile, Phe, Met, or Trp.

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Amino acid 4 may may be absent or present

<400>  198

Xaa Xaa Xaa Xaa 
1               


<210>  199
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  199

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Ser Arg His Trp Ser Asp Glu Val Asp 
        35                  40              


<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide

<400>  200

Ser Arg His Trp Ser Asp Glu Val Asp 
1               5                   


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant polypeptide


<220>
<221>  VARIANT
<222>  (1)..(5)
<223>  Any one or all of the amino acids 1-5 may be absent or present

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is Ile, Gln, Val, or Leu

<220>
<221>  VARIANT
<222>  (8)..(9)
<223>  Any one or all of the amino acids 8-9 may be absent or present

<400>  201

Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa 
1               5                   


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease recognition site


<220>
<221>  VARIANT
<222>  (1)..(5)
<223>  Any one all of the amino acids 1-5 may be abset or present

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Amino acid 7 may be abset or present

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Val, Ser, Ile, Gln, Ala, Arg, or Thr

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Amino acid 9 may be absent or present

<400>  202

Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa 
1               5                   


