                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> COMPOSITIONS AND METHODS FOR NEUROPROTECTION AND/OR 
      NEUROREGENERATION

<130> 167705-025001/PCT

<140> PCT/US2022/012311
<141> 2022-01-13

<150> 63/138,091
<151> 2021-01-15

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 5814
<212> DNA
<213> Homo sapiens

<400> 1
agtgacgggc gcagcctcgg cagcggcggc ggcggagccc tgaggcgaca gcagctgcgg       60

gaggcgacgg gctgcggcct gcggaacctg aggcagctgg ggagggccgg gcgcgccggc      120

cggatagcga gccgcgctgg cggcggcggt ggccgcgatg atggagatcc agatggacga      180

gggcggcggc gtggtggtgt accaggacga ctactgctcc ggctcggtga tgtcggagcg      240

ggtgtcgggc ctggcgggct ccatctaccg cgagttcgag cgcctcatcc actgctacga      300

cgaggaggtg gtcaaggagc tcatgccgct ggtggtgaac gtgctggaga acctagactc      360

ggtgctcagc gagaaccagg agcacgaggt ggagctggag ctgctgcgcg aggacaacga      420

gcagctgctc acccagtacg agcgtgagaa ggcgctgcgc aggcaggcgg aggagaaatt      480

cattgagttt gaagatgctc tggaacaaga gaagaaagag ctgcaaatcc aggtggagca      540

ctacgagttc cagacgcgcc agctggagct gaaggccaag aactatgccg atcagatttc      600

ccggttggag gagcgggagt cggagatgaa gaaggagtac aatgccctgc accagcggca      660

cacagagatg atacagacct acgtggagca cattgagagg tccaagatgc agcaggtcgg      720

aggaaacagc cagaccgaga gcagcctgcc ggggcggagc aggaaggagc gccccacctc      780

cctgaacgtg ttccccctgg ctgacggcac ggtacgtgca cagatcgggg gcaagctcgt      840

gcctgcgggg gaccactggc acctgagtga cctcggccag ctgcagtcca gctccagcta      900

ccagtgtcca caggatgaaa tgtccgagtc aggccagtcc tcggcggccg ccacacccag      960

caccacaggc accaagtcca acacgcccac atcctccgtg ccctcggccg ccgtcacacc     1020

cctcaacgag agcctgcagc ccctggggga ctatggcgtg ggctccaaga acagcaagcg     1080

tgcccgggag aagcgcgaca gccgcaacat ggaagtacag gtcacccagg agatgcgcaa     1140

cgtcagtata ggcatgggca gcagtgacga gtggtctgat gttcaagaca ttattgactc     1200

cacgccagag ctggacatgt gtccagagac ccgcctggac cgcacaggaa gcagcccaac     1260

ccagggcatc gtgaacaaag ctttcggcat caacaccgac tccctgtacc atgagctgtc     1320

gacggcaggg tctgaggtca tcggggatgt ggacgaaggg gccgacctcc taggggagtt     1380

ctcagtgcgc gatgatttct ttggaatggg caaagaagtg gggaatctgc tactggaaaa     1440

ctcacagctt ctggaaacca aaaacgcctt gaatgtggtg aagaatgacc tgattgccaa     1500

ggtcgaccag ctgtccgggg agcaggaggt gctgaggggc gagttggagg ctgctaagca     1560

ggccaaagtc aagctggaaa accgtatcaa ggagctggaa gaggaactga aaagagtgaa     1620

gtccgaggcc atcatcgccc gccgtgaacc caaagaagag gcggaggatg taagcagcta     1680

tctctgtaca gaatcggaca aaatccccat ggcccagcgc cgccgcttca cgcgggtgga     1740

gatggcccgt gtgctcatgg agcggaacca gtacaaggag cggctgatgg agctgcagga     1800

ggctgtgcgg tggactgaga tgatcagagc gtcccgagag cacccatccg tccaggagaa     1860

gaagaagtcg accatctggc agttcttcag ccgcctcttc agctcttcct ccagcccccc     1920

tccggccaag cgcccctatc cctcggtgaa catccactac aagtcaccca ccactgccgg     1980

cttcagccag cgccgcaacc atgccatgtg cccgatctcg gcaggcagcc ggcccctgga     2040

attcttccct gacgacgact gcacgtcctc cgcccgtcga gagcagaagc gcgagcagta     2100

ccgccaggtg cgtgagcacg tgcgtaacga cgacggccgt ctgcaggcct gcggctggag     2160

cctgcccgcc aagtacaagc agctgagtcc caacgggggc caggaggaca cgcggatgaa     2220

gaacgtgccg gtgccggtgt actgccgccc tctggtggag aaggacccca ccatgaagct     2280

gtggtgtgcc gcgggcgtca acctgagcgg gtggaggccc aatgaggacg acgctgggaa     2340

tggagtcaag ccagcgccag gccgcgatcc cctgacctgc gaccgcgaag gagacggcga     2400

gcccaagagc gcccacacgt ctcccgagaa gaagaaggcc aaggagctcc ctgaaatgga     2460

cgccacctcc agccgggtgt ggatcctgac cagcaccctg accaccagca aggtggtgat     2520

catcgacgcc aaccagccgg gcacggtggt ggaccagttc accgtctgca acgcgcacgt     2580

gctgtgcatc tccagcatcc ccgcggccag cgacagcgac taccctcccg gggagatgtt     2640

cctggacagc gacgtgaacc cagaggaccc gggcgcagat ggcgtgctgg ccggtatcac     2700

cctggtgggc tgtgccaccc gctgcaacgt gccgcggagc aactgctcct cccgagggga     2760

caccccagtg ctagacaagg ggcaggggga ggtggccacc atcgccaacg ggaaggtcaa     2820

cccgtcccag tccacagagg aggccacaga ggccacggag gtgccagacc ctgggcccag     2880

cgagccagag acagccacat tgcggcccgg gcctctcaca gagcacgtct tcactgaccc     2940

agccccgacc ccgtcctctg gcccccagcc tggcagcgag aacgggccag agcctgacag     3000

cagcagcaca cggccagagc cagagcccag cggggacccc acgggagcag gcagcagtgc     3060

tgcacccacc atgtggctgg gagcccagaa cggctggctc tatgtgcact cggctgtggc     3120

caactggaag aagtgcctgc actccatcaa gctgaaggat tctgtgctga gcctggtgca     3180

tgtcaaaggc cgtgtgctgg tggctctggc ggacgggacc ctggccatct tccaccgtgg     3240

tgaagatggc cagtgggatc tgagcaacta tcacctaatg gacctgggcc acccgcacca     3300

ctccatccgc tgcatggctg ttgtgtacga ccgcgtgtgg tgtggctaca agaacaaggt     3360

gcacgtcatc cagcccaaga ccatgcagat agagaagtca tttgacgccc acccgcggcg     3420

ggagagccag gtgcggcagc tggcgtggat cggcgatggc gtatgggtgt ccatccgcct     3480

ggactccacc ctgaggctct accatgcaca cacgcaccag catctacagg acgtggacat     3540

tgagccctac gtcagcaaga tgctaggcac tggcaagctg ggtttctcct tcgtacgcat     3600

cacggccctg cttgtcgcgg gcagccggct ctgggtgggc accggcaacg gagtggtcat     3660

ctccatcccc ctgacagaga gtgagtggcc tgcacacctg caggggcagt ggtgctgcca     3720

gaggtgtacg tgggttcacg gggtggctct gcagggccac cttggagggt gccttgctgc     3780

ccctacgctg accgctctcc tcttctccca tgctcctccc atgtccccag ctgtggtcct     3840

gcaccgaggc cagctcctgg ggctccgagc caataagaca tcccccacct ctggggaggg     3900

cgcccgtccc gggggcatca tccacgtgta tggcgatgac agcagtgaca gggcggccag     3960

cagcttcatc ccctactgct ccatggccca ggcccagcta tgcttccatg ggcaccgcga     4020

tgccgtgaag ttctttgtct cggtgccagg gaacgtgctg gccaccctga atgggagtgt     4080

gctggacagc ccagccgagg gccctgggcc agctgcccct gcctcggagg tcgagggcca     4140

gaagctgcgg aacgtgctgg tgctgagcgg cggggagggc tacatcgact tccgcattgg     4200

agacggagag gacgacgaga cggaggaggg cgcaggggac atgagccagg tgaagcccgt     4260

gctgtccaag gcagagcgca gtcacatcat cgtgtggcag gtgtcctaca cccccgagtg     4320

aagctgctgc cctgcctggc ccgacctgta cataggaccc ccgaccacct gacccccgcc     4380

cggcccgcgg ggtagccagc caggcgccgc cgcccctctt ctaacctctc aacctgcagc     4440

tttcacctga gtctggcccc tccagcgggc agggagtgcg gggatgcgga tcagctggga     4500

ggaggagggg aggggaactt ccacccgagg ggaagatgct ctcgggacag tttcccgggc     4560

agctcctggc cagcttccag cccagagtcc tcaagtccag ggcaccttgg gcccagcgca     4620

ggcagaatcc gaggtggtcc tggctctacc ctgggcctcc tactccccag cacccctgga     4680

ggaggcaggg gctccccgcc gccgaggctg cctgccctgg gcccacctct gcatgctgct     4740

catggggcca ccctgcctcc tgggccctca ctctgcctag gggagctggg ccaggcacta     4800

gcctttgccc agggaggtgg gcctcaggct gcccaggtgc ctgcacccca gccggccttc     4860

tctggggcct ccccgtcgtc aagcctctat cctgtctgtc cccaccccag ctgtcccctg     4920

cccagggagc tggcataaaa gcacgaggcc cggctccctg gggcagctgc ttgagaacag     4980

agactgctac cccatcctgc ccatgcaggc aggctcttgc cagccccgtt ctgacccgtg     5040

tccccccagg ctctgcctgg gcagaagact caccttggag gagtgggccc tggagtcctg     5100

tccctcccag aagcccccag ggtgggattt ctcaggctgc cagggcaggc ccaggcctca     5160

ggaagaaggg gaggcccctg gcctctccgg gatcagtcct aggacacagg ctcagcctca     5220

ggttgatggg ggatgatgtg ctcccggggc ctgcctcctg cacggggctc cacggagccc     5280

agctcccaga cacgctacta agtgcctagg gttgcccgct gtggcctgct tccagggagc     5340

aacagagagg ccaccaagca gaggcccgtg gggctgagga tggagccgcc cccagccgac     5400

tccaagcccg cagagggcag acgccaccct ggactgctct ccctgcccag ctgggcctct     5460

ctggcctatt cctaccttcc aggcccactg cactcctgtc tgggaggccc ttatgagggc     5520

agcccagccc ccgcacccac ccccaaccag agaagcacag atcttgggga gctgccccac     5580

aagccccgct ggccaccgag ggctgcagcc gctgcgctgc cggcttctcc ccaccaccct     5640

gccacctcca ctgtgatgta tgtccgctcc ctcgtctgtt cccccaggat ctcgaagtga     5700

ctccgggctg agcagtgggg cggctggggg aggggtgacg attctcctca ggctttggcc     5760

ctgcaagcaa acccacatat ctgctctgta tgtaataaat gtcttaacgt cgta           5814


<210> 2
<211> 1336
<212> PRT
<213> Homo sapiens

<400> 2
Met Met Glu Ile Gln Met Asp Glu Gly Gly Gly Val Val Val Tyr Gln 
1               5                   10                  15      


Asp Asp Tyr Cys Ser Gly Ser Val Met Ser Glu Arg Val Ser Gly Leu 
            20                  25                  30          


Ala Gly Ser Ile Tyr Arg Glu Phe Glu Arg Leu Ile His Cys Tyr Asp 
        35                  40                  45              


Glu Glu Val Val Lys Glu Leu Met Pro Leu Val Val Asn Val Leu Glu 
    50                  55                  60                  


Asn Leu Asp Ser Val Leu Ser Glu Asn Gln Glu His Glu Val Glu Leu 
65                  70                  75                  80  


Glu Leu Leu Arg Glu Asp Asn Glu Gln Leu Leu Thr Gln Tyr Glu Arg 
                85                  90                  95      


Glu Lys Ala Leu Arg Arg Gln Ala Glu Glu Lys Phe Ile Glu Phe Glu 
            100                 105                 110         


Asp Ala Leu Glu Gln Glu Lys Lys Glu Leu Gln Ile Gln Val Glu His 
        115                 120                 125             


Tyr Glu Phe Gln Thr Arg Gln Leu Glu Leu Lys Ala Lys Asn Tyr Ala 
    130                 135                 140                 


Asp Gln Ile Ser Arg Leu Glu Glu Arg Glu Ser Glu Met Lys Lys Glu 
145                 150                 155                 160 


Tyr Asn Ala Leu His Gln Arg His Thr Glu Met Ile Gln Thr Tyr Val 
                165                 170                 175     


Glu His Ile Glu Arg Ser Lys Met Gln Gln Val Gly Gly Asn Ser Gln 
            180                 185                 190         


Thr Glu Ser Ser Leu Pro Gly Arg Arg Lys Glu Arg Pro Thr Ser Leu 
        195                 200                 205             


Asn Val Phe Pro Leu Ala Asp Gly Thr Val Arg Ala Gln Ile Gly Gly 
    210                 215                 220                 


Lys Leu Val Pro Ala Gly Asp His Trp His Leu Ser Asp Leu Gly Gln 
225                 230                 235                 240 


Leu Gln Ser Ser Ser Ser Tyr Gln Cys Pro Gln Asp Glu Met Ser Glu 
                245                 250                 255     


Ser Gly Gln Ser Ser Ala Ala Ala Thr Pro Ser Thr Thr Gly Thr Lys 
            260                 265                 270         


Ser Asn Thr Pro Thr Ser Ser Val Pro Ser Ala Ala Val Thr Pro Leu 
        275                 280                 285             


Asn Glu Ser Leu Gln Pro Leu Gly Asp Tyr Gly Val Gly Ser Lys Asn 
    290                 295                 300                 


Ser Lys Arg Ala Arg Glu Lys Arg Asp Ser Arg Asn Met Glu Val Gln 
305                 310                 315                 320 


Val Thr Gln Glu Met Arg Asn Val Ser Ile Gly Met Gly Ser Ser Asp 
                325                 330                 335     


Glu Trp Ser Asp Val Gln Asp Ile Ile Asp Ser Thr Pro Glu Leu Asp 
            340                 345                 350         


Met Cys Pro Glu Thr Arg Leu Asp Arg Thr Gly Ser Ser Pro Thr Gln 
        355                 360                 365             


Gly Ile Val Asn Lys Ala Phe Gly Ile Asn Thr Asp Ser Leu Tyr His 
    370                 375                 380                 


Glu Leu Ser Thr Ala Gly Ser Glu Val Ile Gly Asp Val Asp Glu Gly 
385                 390                 395                 400 


Ala Asp Leu Leu Gly Glu Phe Ser Val Arg Asp Asp Phe Phe Gly Met 
                405                 410                 415     


Gly Lys Glu Val Gly Asn Leu Leu Leu Glu Asn Ser Gln Leu Leu Glu 
            420                 425                 430         


Thr Lys Asn Ala Leu Asn Val Val Lys Asn Asp Leu Ile Ala Lys Val 
        435                 440                 445             


Asp Gln Leu Ser Gly Glu Gln Glu Val Leu Arg Gly Glu Leu Glu Ala 
    450                 455                 460                 


Ala Lys Gln Ala Lys Val Lys Leu Glu Asn Arg Ile Lys Glu Leu Glu 
465                 470                 475                 480 


Glu Glu Leu Lys Arg Val Lys Ser Glu Ala Ile Ile Ala Arg Arg Glu 
                485                 490                 495     


Pro Lys Glu Glu Ala Glu Asp Val Ser Ser Tyr Leu Cys Thr Glu Ser 
            500                 505                 510         


Asp Lys Ile Pro Met Ala Gln Arg Arg Arg Phe Thr Arg Val Glu Met 
        515                 520                 525             


Ala Arg Val Leu Met Glu Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu 
    530                 535                 540                 


Leu Gln Glu Ala Val Arg Trp Thr Glu Met Ile Arg Ala Ser Arg Glu 
545                 550                 555                 560 


His Pro Ser Val Gln Glu Lys Lys Lys Ser Thr Ile Trp Gln Phe Phe 
                565                 570                 575     


Ser Arg Leu Phe Ser Ser Ser Ser Ser Pro Pro Pro Ala Lys Arg Pro 
            580                 585                 590         


Tyr Pro Ser Val Asn Ile His Tyr Lys Ser Pro Thr Thr Ala Gly Phe 
        595                 600                 605             


Ser Gln Arg Arg Asn His Ala Met Cys Pro Ile Ser Ala Gly Ser Arg 
    610                 615                 620                 


Pro Leu Glu Phe Phe Pro Asp Asp Asp Cys Thr Ser Ser Ala Arg Arg 
625                 630                 635                 640 


Glu Gln Lys Arg Glu Gln Tyr Arg Gln Val Arg Glu His Val Arg Asn 
                645                 650                 655     


Asp Asp Gly Arg Leu Gln Ala Cys Gly Trp Ser Leu Pro Ala Lys Tyr 
            660                 665                 670         


Lys Gln Leu Ser Pro Asn Gly Gly Gln Glu Asp Thr Arg Met Lys Asn 
        675                 680                 685             


Val Pro Val Pro Val Tyr Cys Arg Pro Leu Val Glu Lys Asp Pro Thr 
    690                 695                 700                 


Met Lys Leu Trp Cys Ala Ala Gly Val Asn Leu Ser Gly Trp Arg Pro 
705                 710                 715                 720 


Asn Glu Asp Asp Ala Gly Asn Gly Val Lys Pro Ala Pro Gly Arg Asp 
                725                 730                 735     


Pro Leu Thr Cys Asp Arg Glu Gly Asp Gly Glu Pro Lys Ser Ala His 
            740                 745                 750         


Thr Ser Pro Glu Lys Lys Lys Ala Lys Glu Leu Pro Glu Met Asp Ala 
        755                 760                 765             


Thr Ser Ser Arg Val Trp Ile Leu Thr Ser Thr Leu Thr Thr Ser Lys 
    770                 775                 780                 


Val Val Ile Ile Asp Ala Asn Gln Pro Gly Thr Val Val Asp Gln Phe 
785                 790                 795                 800 


Thr Val Cys Asn Ala His Val Leu Cys Ile Ser Ser Ile Pro Ala Ala 
                805                 810                 815     


Ser Asp Ser Asp Tyr Pro Pro Gly Glu Met Phe Leu Asp Ser Asp Val 
            820                 825                 830         


Asn Pro Glu Asp Pro Gly Ala Asp Gly Val Leu Ala Gly Ile Thr Leu 
        835                 840                 845             


Val Gly Cys Ala Thr Arg Cys Asn Val Pro Arg Ser Asn Cys Ser Ser 
    850                 855                 860                 


Arg Gly Asp Thr Pro Val Leu Asp Lys Gly Gln Gly Glu Val Ala Thr 
865                 870                 875                 880 


Ile Ala Asn Gly Lys Val Asn Pro Ser Gln Ser Thr Glu Glu Ala Thr 
                885                 890                 895     


Glu Ala Thr Glu Val Pro Asp Pro Gly Pro Ser Glu Pro Glu Thr Ala 
            900                 905                 910         


Thr Leu Arg Pro Gly Pro Leu Thr Glu His Val Phe Thr Asp Pro Ala 
        915                 920                 925             


Pro Thr Pro Ser Ser Gly Pro Gln Pro Gly Ser Glu Asn Gly Pro Glu 
    930                 935                 940                 


Pro Asp Ser Ser Ser Thr Arg Pro Glu Pro Glu Pro Ser Gly Asp Pro 
945                 950                 955                 960 


Thr Gly Ala Gly Ser Ser Ala Ala Pro Thr Met Trp Leu Gly Ala Gln 
                965                 970                 975     


Asn Gly Trp Leu Tyr Val His Ser Ala Val Ala Asn Trp Lys Lys Cys 
            980                 985                 990         


Leu His Ser Ile Lys Leu Lys Asp  Ser Val Leu Ser Leu  Val His Val 
        995                 1000                 1005             


Lys Gly  Arg Val Leu Val Ala  Leu Ala Asp Gly Thr  Leu Ala Ile 
    1010                 1015                 1020             


Phe His  Arg Gly Glu Asp Gly  Gln Trp Asp Leu Ser  Asn Tyr His 
    1025                 1030                 1035             


Leu Met  Asp Leu Gly His Pro  His His Ser Ile Arg  Cys Met Ala 
    1040                 1045                 1050             


Val Val  Tyr Asp Arg Val Trp  Cys Gly Tyr Lys Asn  Lys Val His 
    1055                 1060                 1065             


Val Ile  Gln Pro Lys Thr Met  Gln Ile Glu Lys Ser  Phe Asp Ala 
    1070                 1075                 1080             


His Pro  Arg Arg Glu Ser Gln  Val Arg Gln Leu Ala  Trp Ile Gly 
    1085                 1090                 1095             


Asp Gly  Val Trp Val Ser Ile  Arg Leu Asp Ser Thr  Leu Arg Leu 
    1100                 1105                 1110             


Tyr His  Ala His Thr His Gln  His Leu Gln Asp Val  Asp Ile Glu 
    1115                 1120                 1125             


Pro Tyr  Val Ser Lys Met Leu  Gly Thr Gly Lys Leu  Gly Phe Ser 
    1130                 1135                 1140             


Phe Val  Arg Ile Thr Ala Leu  Leu Val Ala Gly Ser  Arg Leu Trp 
    1145                 1150                 1155             


Val Gly  Thr Gly Asn Gly Val  Val Ile Ser Ile Pro  Leu Thr Glu 
    1160                 1165                 1170             


Thr Val  Val Leu His Arg Gly  Gln Leu Leu Gly Leu  Arg Ala Asn 
    1175                 1180                 1185             


Lys Thr  Ser Pro Thr Ser Gly  Glu Gly Ala Arg Pro  Gly Gly Ile 
    1190                 1195                 1200             


Ile His  Val Tyr Gly Asp Asp  Ser Ser Asp Arg Ala  Ala Ser Ser 
    1205                 1210                 1215             


Phe Ile  Pro Tyr Cys Ser Met  Ala Gln Ala Gln Leu  Cys Phe His 
    1220                 1225                 1230             


Gly His  Arg Asp Ala Val Lys  Phe Phe Val Ser Val  Pro Gly Asn 
    1235                 1240                 1245             


Val Leu  Ala Thr Leu Asn Gly  Ser Val Leu Asp Ser  Pro Ala Glu 
    1250                 1255                 1260             


Gly Pro  Gly Pro Ala Ala Pro  Ala Ser Glu Val Glu  Gly Gln Lys 
    1265                 1270                 1275             


Leu Arg  Asn Val Leu Val Leu  Ser Gly Gly Glu Gly  Tyr Ile Asp 
    1280                 1285                 1290             


Phe Arg  Ile Gly Asp Gly Glu  Asp Asp Glu Thr Glu  Glu Gly Ala 
    1295                 1300                 1305             


Gly Asp  Met Ser Gln Val Lys  Pro Val Leu Ser Lys  Ala Glu Arg 
    1310                 1315                 1320             


Ser His  Ile Ile Val Trp Gln  Val Ser Tyr Thr Pro  Glu 
    1325                 1330                 1335     


<210> 3
<211> 1313
<212> DNA
<213> Homo sapiens

<400> 3
gagcttgctg cattgcagcc gccgcggcgc cgctcggctc ttcactccca acaatggcgg       60

ctccgagccc gagcggcggc ggcggctccg ggggcggcag cggcagcggc acccccggcc      120

ccgtagggtc cccggcgcca ggccacccgg ccgtcagcag catgcagggc tttcagataa      180

acttctgtga aaaggcacaa agtaaacgca aagcactgaa gttgaatttt gcaaatccac      240

ctttcaaatc tacagcaagg tttactctga atcccaatcc tacaggagtt caaaacccac      300

acatagagag actgagaaca cacagcattg agtcatcagg aaaactgaag atctcccctg      360

aacaacactg ggatttcact gcagaggact tgaaagacct tggagaaatt ggacgaggag      420

cttatggttc tgtcaacaaa atggtccaca aaccaagtgg gcaaataatg gcagttaaaa      480

gaattcggtc aacagtggat gaaaaagaac aaaaacaact tcttatggat ttggatgtag      540

taatgcggag tagtgattgc ccatacattg ttcagtttta tggtgcactc ttcagagagg      600

gtgactgttg gatctgtatg gaactcatgt ctacctcgtt tgataagttt tacaaatatg      660

tatatagtgt attagatgat gttattccag aagaaatttt aggcaaaatc actttagcaa      720

ctgtgaaagc actaaaccac ttaaaagaaa acttgaaaat tattcacaga gatatcaaac      780

cttccaatat tcttctggac agaagtggaa atattaagct ctgtgacttc ggcatcagtg      840

gacagcttgt ggactctatt gccaagacaa gagatgctgg ctgtaggcca tacatggcac      900

ctgaaagaat agacccaagc gcatcacgac aaggatatga tgtccgctct gatgtctgga      960

gtttggggat cacattgata ataggagtca actattatct gcaactgcac taagaatggg     1020

aacaggacaa gccagcttac ctgcagtcaa ttcattgatg aaggcacata ggcttctccc     1080

atctcaggca aggtgtagta tgtccagtaa tactgtatat agtgtgtata ttaagtatac     1140

gtatttttat atgtggaaaa tagtttctac ttgcaatatt ctattcactg aatagtaaaa     1200

tcacaagtga atgagctgaa agtaattcag tttttgaggg acaatatatt agtccattct     1260

cacactactg taaagaacta catgagactg ggtaatttat gaagagaggt tta            1313


<210> 4
<211> 399
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Ala Pro Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ser Gly Thr Pro Gly Pro Val Gly Ser Pro Ala Pro Gly His Pro 
            20                  25                  30          


Ala Val Ser Ser Met Gln Gly Lys Arg Lys Ala Leu Lys Leu Asn Phe 
        35                  40                  45              


Ala Asn Pro Pro Phe Lys Ser Thr Ala Arg Phe Thr Leu Asn Pro Asn 
    50                  55                  60                  


Pro Thr Gly Val Gln Asn Pro His Ile Glu Arg Leu Arg Thr His Ser 
65                  70                  75                  80  


Ile Glu Ser Ser Gly Lys Leu Lys Ile Ser Pro Glu Gln His Trp Asp 
                85                  90                  95      


Phe Thr Ala Glu Asp Leu Lys Asp Leu Gly Glu Ile Gly Arg Gly Ala 
            100                 105                 110         


Tyr Gly Ser Val Asn Lys Met Val His Lys Pro Ser Gly Gln Ile Met 
        115                 120                 125             


Ala Val Lys Arg Ile Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln 
    130                 135                 140                 


Leu Leu Met Asp Leu Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr 
145                 150                 155                 160 


Ile Val Gln Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile 
                165                 170                 175     


Cys Met Glu Leu Met Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val 
            180                 185                 190         


Tyr Ser Val Leu Asp Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile 
        195                 200                 205             


Thr Leu Ala Thr Val Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys 
    210                 215                 220                 


Ile Ile His Arg Asp Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser 
225                 230                 235                 240 


Gly Asn Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp 
                245                 250                 255     


Ser Ile Ala Lys Thr Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro 
            260                 265                 270         


Glu Arg Ile Asp Pro Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser 
        275                 280                 285             


Asp Val Trp Ser Leu Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg 
    290                 295                 300                 


Phe Pro Tyr Pro Lys Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val 
305                 310                 315                 320 


Val Lys Gly Asp Pro Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe 
                325                 330                 335     


Ser Pro Ser Phe Ile Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu 
            340                 345                 350         


Ser Lys Arg Pro Lys Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu 
        355                 360                 365             


Met Tyr Glu Glu Arg Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile 
    370                 375                 380                 


Leu Asp Gln Met Pro Ala Thr Pro Ser Ser Pro Met Tyr Val Asp 
385                 390                 395                 


<210> 5
<211> 3375
<212> DNA
<213> Homo sapiens

<400> 5
agtgcggtgt ttgtctgccg gactgacggg cggccgggcg gtgcgcggcg gcggtggcgg       60

cggggaagat ggcggcgtcc tccctggaac agaagctgtc ccgcctggaa gcaaagctga      120

agcaggagaa ccgggaggcc cggcggagga tcgacctcaa cctggatatc agcccccagc      180

ggcccaggcc caccctgcag ctcccgctgg ccaacgatgg gggcagccgc tcgccatcct      240

cagagagctc cccgcagcac cccacgcccc ccgcccggcc ccgccacatg ctggggctcc      300

cgtcaaccct gttcacaccc cgcagcatgg agagcattga gattgaccag aagctgcagg      360

agatcatgaa gcagacgggc tacctgacca tcgggggcca gcgctaccag gcagaaatca      420

acgacctgga gaacttgggc gagatgggca gcggcacctg cggccaggtg tggaagatgc      480

gcttccggaa gaccggccac gtcattgccg ttaagcaaat gcggcgctcc gggaacaagg      540

aggagaacaa gcgcatcctc atggacctgg atgtggtgct gaagagccac gactgcccct      600

acatcgtgca gtgctttggg acgttcatca ccaacacgga cgtcttcatc gccatggagc      660

tcatgggcac ctgcgctgag aagctcaaga agcggatgca gggccccatc cccgagcgca      720

ttctgggcaa gatgacagtg gcgattgtga aggcgctgta ctacctgaag gagaagcacg      780

gtgtcatcca ccgcgacgtc aagccctcca acatcctgct ggacgagcgg ggccagatca      840

agctctgcga cttcggcatc agcggccgcc tggtggactc caaagccaag acgcggagcg      900

ccggctgtgc cgcctacatg gcacccgagc gcattgaccc cccagacccc accaagccgg      960

actatgacat ccgggccgac gtatggagcc tgggcatctc gttggtggag ctggcaacag     1020

gacagtttcc ctacaagaac tgcaagacgg actttgaggt cctcaccaaa gtcctacagg     1080

aagagccccc gcttctgccc ggacacatgg gcttctcggg ggacttccag tccttcgtca     1140

aagactgcct tactaaagat cacaggaaga gaccaaagta taataagcta cttgaacaca     1200

gcttcatcaa gcgctacgag acgctggagg tggacgtggc gtcctggttc aaggatgtca     1260

tggcgaagac tgagtcaccg cggactagcg gcgtcctgag ccagccccac ctgcccttct     1320

tcaggtagct gcttggcggc ggccagcccc acagggggcc aggggcatgg ccacaggccc     1380

ccctccccac ttggccaccc agctgcctgc caggggagac ctgggacctg gacggccacc     1440

taggactgag gacagagagt ggggggtgcc cacccacccc ccccgccccg ggcctaccaa     1500

gcccccgccc ttcccacccc ggggtcagcc ggccgtgtgc gtcccccgac agacactgtg     1560

aacggaagac agcaggccgc gatcagagtc gctgttcatt cagccgcagc ctctgggccg     1620

gggcggcccc caggggccag gagagagccc tggagtcccg cagccaccat gcacgctccc     1680

agcgtgctgt gtccttcgcc actcccacgc gcccgttcct cttccgtcgc cctctgtccc     1740

ctgctctacc tctctgtcct tgtctggctc tcccgtcacc ctccctgcct ctgtctctct     1800

tctggcctga gcctgggccc agccacctcc tgacgggtcc cctgggtctg cataggtctc     1860

ccatggcgca atgagtcagt ggcccccagc caggcagtgt gggcattgcc actgcggctg     1920

gacggggctg cgcgctcgcg ctctctctct ctctctctct ctctctttga tctcaggggg     1980

tcctttttgg agtttattgt attttattgt acttggtggg gtgtttgggg tgggggcgga     2040

ggagagcttg ttctcgtggg gttgtcggta ccttcagaaa cttttaccaa agtcacgatt     2100

agctgcttgt ggtggggccc caaccgccct cgggcactgg ggagctgggc tggggctgct     2160

gctctggggt ctccgggggc cacagcttgg ggtgagttga agacctcagg ggatgtggag     2220

gggtctgcgg ggccctggcc gcacaggatg gccttcaggg aaggtggtct tggggcatgg     2280

tgcagagcag gtgaccggag ggaatcggtg acggagcggg gccaagggag gggtccggag     2340

ggagtcaggg atggagggca gagggagtgg atgtgggggt ttgaggacgt gtgacaagct     2400

ccagcagggg tgggggccgg gctgagggtg ggggtgcgag gtggtcactc ccatcgtgcc     2460

cctggccgtc cctccactca cccacacctg gcccagtcca cgttgaggtc caggactggg     2520

aaggaccggg tgagtgcacc ggggacccag gccaggtgcc ccccggagcc tgctggggtg     2580

gccagagcag gagggggtgt gtttcctttt tgtgggtgtt gcatgcaaat caagtggaca     2640

agaaaaaata acaaaacaaa aaacaagaaa aaaaaaacac aaaaccccgt aaaatcacaa     2700

agaaaatcca acaccaaagg cgcagaagcc ggctggccgt ggtgggggca gcgtaggcgt     2760

agcatccctc tcctctcact tagcctgttg actcttgtta ttatcatgat attcacaaaa     2820

cgccgcatgt ttaaaaagtc atagatgtca tcttctctct gcccccaggg aggaaagcca     2880

ccttctcttg ccccttggcc cctttgtcag gggccagggg tctgccgggt gggggtgcca     2940

acaggcctgg ccctttcctc ccctgcatcc agccatgggg gcctctgcga ttgccggaag     3000

gttgcatggc tggtcccagg gccagcacag gcccgaggcc gggctgcctg gttttatttt     3060

tatttaactt tattttctgt tttatgagtg tgtgtccgcc cacccccacc cccttcagtg     3120

ttaagtgggg agccctgggg gagtctctcc tgcctcccag cctctcccaa gacctccccc     3180

ctcgtcacca gccatccctc tggaccaggc agagggcgga ccgggtgggc aggggcctga     3240

gggtggctcg ggccagccca ccagccaatg gacccctcct caggccgcca gtgtcgccct     3300

gccccttttt aaaacaaaat gccctcgttt gtaaaccctt agacgcttga gaataaaccc     3360

cttccttttc ttcca                                                      3375


<210> 6
<211> 419
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys 
1               5                   10                  15      


Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu 
            20                  25                  30          


Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala 
        35                  40                  45              


Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His 
    50                  55                  60                  


Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr 
65                  70                  75                  80  


Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu 
                85                  90                  95      


Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg 
            100                 105                 110         


Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser 
        115                 120                 125             


Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His 
    130                 135                 140                 


Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn 
145                 150                 155                 160 


Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys 
                165                 170                 175     


Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val 
            180                 185                 190         


Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys 
        195                 200                 205             


Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val 
    210                 215                 220                 


Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile 
225                 230                 235                 240 


His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln 
                245                 250                 255     


Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys 
            260                 265                 270         


Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg 
        275                 280                 285             


Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp 
    290                 295                 300                 


Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe 
305                 310                 315                 320 


Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu 
                325                 330                 335     


Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp 
            340                 345                 350         


Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg 
        355                 360                 365             


Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu 
    370                 375                 380                 


Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys 
385                 390                 395                 400 


Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro 
                405                 410                 415     


Phe Phe Arg 
            


<210> 7
<211> 3293
<212> DNA
<213> Homo sapiens

<400> 7
gaggtaaaca agatggcggc ggcgtgtcgg gcgcggaagg gggaggcggc ccggggcgcc       60

cgcgagtgag gcgcggggcg gcgaagggag cgcgggtggc ggcacttgct gccgcggcct      120

tggatgggct gggcccccct cgccgctccg cctcctccac acgcgcggcg gccgcggcga      180

gggggacgcg ccgcccgggg cccggcacct tcgggaaccc cccggcccgg agcctgcggc      240

ctgcgccgcc tcggccgccg ggagccccgt ggagcccccg ccgccgcgcc gccccgcgga      300

ccggacgctg agggcactcg gggcggggcg cgcgctcggg cagacgtttg cggggagggg      360

ggcgcctgcc gggccccggc gaccaccttg ggggtcgcgg gccggctcgg ggggcgccca      420

gtgcgggccc tcgcgggcgc cgggcagcga ccagccctga gcggagctgt tggccgcggc      480

gggaggcctc ccggacgccc ccagcccccc gaacgctcgc ccgggccggc gggagtcggc      540

gccccccggg aggtccgctc ggtcgtccgc ggcggagcgt ttgctcctgg gacaggcggt      600

gggaccgggg cgtcgccgga gacgccccca gcgaagttgg gctctccagg tgtgggggtc      660

ccggggggta gcgacgtcgc ggacccggcc tgtgggatgg gcggcccgga gaagactgcg      720

ctcggccgtg ttcatacttg tccgtgggcc tgaggtcccc ggaggatgac ctagcactga      780

aaagccccgg ccggcctccc cagggtcccc gaggacgaag ttgaccctga ccgggccgtc      840

tcccagttct gaggcccggg tcccactgga actcgcgtct gagccgccgt cccggacccc      900

cggtgcccgc cggtccgcag accctgcacc gggcttggac tcgcagccgg gactgacgtg      960

tagaacaatc gtttctgttg gaagaagggt ttttcccttc cttttggggt ttttgttgcc     1020

tttttttttt cttttttctt tgtaaaattt tggagaaggg aagtcggaac acaaggaagg     1080

accgctcacc cgcggactca gggctggcgg cgggactcca ggaccctggg tccagcatgg     1140

aggtggtgga cccgcagcag ctgggcatgt tcacggaggg cgagctgatg tcggtgggta     1200

tggacacgtt catccaccgc atcgactcca ccgaggtcat ctaccagccg cgccgcaagc     1260

gggccaagct catcggcaag tacctgatgg gggacctgct gggggaaggc tcttacggca     1320

aggtgaagga ggtgctggac tcggagacgc tgtgcaggag ggccgtcaag atcctcaaga     1380

agaagaagtt gcgaaggatc cccaacgggg aggccaacgt gaagaaggaa attcaactac     1440

tgaggaggtt acggcacaaa aatgtcatcc agctggtgga tgtgttatac aacgaagaga     1500

agcagaaaat gtatatggtg atggagtact gcgtgtgtgg catgcaggaa atgctggaca     1560

gcgtgccgga gaagcgtttc ccagtgtgcc aggcccacgg gtacttctgt cagctgattg     1620

acggcctgga gtacctgcat agccagggca ttgtgcacaa ggacatcaag ccggggaacc     1680

tgctgctcac caccggtggc accctcaaaa tctccgacct gggcgtggcc gaggcactgc     1740

acccgttcgc ggcggacgac acctgccgga ccagccaggg ctccccggct ttccagccgc     1800

ccgagattgc caacggcctg gacaccttct ccggcttcaa ggtggacatc tggtcggctg     1860

gggtcaccct ctacaacatc accacgggtc tgtacccctt cgaaggggac aacatctaca     1920

agttgtttga gaacatcggg aaggggagct acgccatccc gggcgactgt ggccccccgc     1980

tctctgacct gctgaaaggg atgcttgagt acgaaccggc caagaggttc tccatccggc     2040

agatccggca gcacagctgg ttccggaaga aacatcctcc ggctgaagca ccagtgccca     2100

tcccaccgag cccagacacc aaggaccggt ggcgcagcat gactgtggtg ccgtacttgg     2160

aggacctgca cggcgcggac gaggacgagg acctcttcga catcgaggat gacatcatct     2220

acactcagga cttcacggtg cccggacagg tcccagaaga ggaggccagt cacaatggac     2280

agcgccgggg cctccccaag gccgtgtgta tgaacggcac agaggcggcg cagctgagca     2340

ccaaatccag ggcggagggc cgggccccca accctgcccg caaggcctgc tccgccagca     2400

gcaagatccg ccggctgtcg gcctgcaagc agcagtgagg ctggccgcct gcagcccgtg     2460

tccaggagcc ccgccaggtg cccgcgccag gccctcagtc ttcctgccgg ttccgcccgc     2520

cctcccggag aggtggccgc catgcttctg tgccgaccac gccccaggac ctccggagcg     2580

ccctgcaggg ccgggcaggg ggacagcagg gaccgggcgc agccctcccc cctcggccgc     2640

ccggcagtgc acgcggcttg ttgacttcgc agccccgggc ggagccttcc cgggcgggcg     2700

tgggaggagg gaggcggcct ccatgcactt tatgtggaga ctactggccc cgcccgtggc     2760

ctcgtgctcc gcagggcgcc cagcgccgtc cggcggcccc gccgcagacc agctggcggg     2820

tgtggagacc aggctcctga ccccgccatg catgcagcgc cacctggaag ccgcgcggcc     2880

gctttggttt tttgtttggt tggttccatt ttcttttttt cttttttttt ttaagaaaaa     2940

ataaaaggtg gatttgagct gtggctgtga ggggtgtttg ggagctgctg ggtggcaggg     3000

gggctgtggg gtcgggctca cgtcgcggcc gcctttgcgc tctcgggtca ccctgctttg     3060

gcggcccggc cggagggcag gaccctcacc tctcccccaa ggccactgcg ctcttgggac     3120

cccagagaaa acccggagca agcaggagtg tgcggtcaat atttatatca tccagaaaag     3180

aaaaacacga gaaacgccat cgcgggatgg tgcagacgcg gcggggactc ggagggtgcc     3240

gtgcgggcga ggccgcccaa atttggcaat aaataaagct tgggaagctt gga            3293


<210> 8
<211> 433
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Val Val Asp Pro Gln Gln Leu Gly Met Phe Thr Glu Gly Glu 
1               5                   10                  15      


Leu Met Ser Val Gly Met Asp Thr Phe Ile His Arg Ile Asp Ser Thr 
            20                  25                  30          


Glu Val Ile Tyr Gln Pro Arg Arg Lys Arg Ala Lys Leu Ile Gly Lys 
        35                  40                  45              


Tyr Leu Met Gly Asp Leu Leu Gly Glu Gly Ser Tyr Gly Lys Val Lys 
    50                  55                  60                  


Glu Val Leu Asp Ser Glu Thr Leu Cys Arg Arg Ala Val Lys Ile Leu 
65                  70                  75                  80  


Lys Lys Lys Lys Leu Arg Arg Ile Pro Asn Gly Glu Ala Asn Val Lys 
                85                  90                  95      


Lys Glu Ile Gln Leu Leu Arg Arg Leu Arg His Lys Asn Val Ile Gln 
            100                 105                 110         


Leu Val Asp Val Leu Tyr Asn Glu Glu Lys Gln Lys Met Tyr Met Val 
        115                 120                 125             


Met Glu Tyr Cys Val Cys Gly Met Gln Glu Met Leu Asp Ser Val Pro 
    130                 135                 140                 


Glu Lys Arg Phe Pro Val Cys Gln Ala His Gly Tyr Phe Cys Gln Leu 
145                 150                 155                 160 


Ile Asp Gly Leu Glu Tyr Leu His Ser Gln Gly Ile Val His Lys Asp 
                165                 170                 175     


Ile Lys Pro Gly Asn Leu Leu Leu Thr Thr Gly Gly Thr Leu Lys Ile 
            180                 185                 190         


Ser Asp Leu Gly Val Ala Glu Ala Leu His Pro Phe Ala Ala Asp Asp 
        195                 200                 205             


Thr Cys Arg Thr Ser Gln Gly Ser Pro Ala Phe Gln Pro Pro Glu Ile 
    210                 215                 220                 


Ala Asn Gly Leu Asp Thr Phe Ser Gly Phe Lys Val Asp Ile Trp Ser 
225                 230                 235                 240 


Ala Gly Val Thr Leu Tyr Asn Ile Thr Thr Gly Leu Tyr Pro Phe Glu 
                245                 250                 255     


Gly Asp Asn Ile Tyr Lys Leu Phe Glu Asn Ile Gly Lys Gly Ser Tyr 
            260                 265                 270         


Ala Ile Pro Gly Asp Cys Gly Pro Pro Leu Ser Asp Leu Leu Lys Gly 
        275                 280                 285             


Met Leu Glu Tyr Glu Pro Ala Lys Arg Phe Ser Ile Arg Gln Ile Arg 
    290                 295                 300                 


Gln His Ser Trp Phe Arg Lys Lys His Pro Pro Ala Glu Ala Pro Val 
305                 310                 315                 320 


Pro Ile Pro Pro Ser Pro Asp Thr Lys Asp Arg Trp Arg Ser Met Thr 
                325                 330                 335     


Val Val Pro Tyr Leu Glu Asp Leu His Gly Ala Asp Glu Asp Glu Asp 
            340                 345                 350         


Leu Phe Asp Ile Glu Asp Asp Ile Ile Tyr Thr Gln Asp Phe Thr Val 
        355                 360                 365             


Pro Gly Gln Val Pro Glu Glu Glu Ala Ser His Asn Gly Gln Arg Arg 
    370                 375                 380                 


Gly Leu Pro Lys Ala Val Cys Met Asn Gly Thr Glu Ala Ala Gln Leu 
385                 390                 395                 400 


Ser Thr Lys Ser Arg Ala Glu Gly Arg Ala Pro Asn Pro Ala Arg Lys 
                405                 410                 415     


Ala Cys Ser Ala Ser Ser Lys Ile Arg Arg Leu Ser Ala Cys Lys Gln 
            420                 425                 430         


Gln 
    


<210> 9
<211> 5126
<212> DNA
<213> Homo sapiens

<400> 9
agctacccgg caccccctcc ccgcggccgg cagcccgctc ggtattatga ttagcgctgg       60

gtgcggggtt tcggcggccg ggagggagtt gtcggcgccg cggccgctgc ggacggacgc      120

tcgcctgccg gctgagatat ccatgacgac attgaaaatg aattttttgt attcaccaga      180

tattcttata tgagaagatc tattttaaac agtctaaata ttttttcttc tgttggacca      240

gcatggcagg atttaagcga gggtatgatg gaaagattgc tggattatat gatctggata      300

aaaccttggg tcgaggccat tttgccgtgg ttaaacttgc caggcatgtc tttacgggtg      360

aaaaggtggc agtaaaagtt attgacaaga caaaactgga cactctagct actggtcatc      420

ttttccagga agtgagatgc atgaaactag tgcagcatcc taacatcgtc cgcctttatg      480

aagttattga cacccagacc aaactatatc ttattctaga acttggggat ggaggagata      540

tgtttgatta tataatgaaa catgaggagg gtcttaatga agacttggcc aagaagtatt      600

ttgctcagat agttcatgct atatcttatt gccataaact ccatgtggtt cacagagact      660

taaaaccaga gaatgtagtc ttctttgaaa aacaaggtct tgtaaagttg acagactttg      720

ggttcagcaa caaatttcaa ccagggaaga agctcactac aagctgtgga tctcttgcat      780

attccgctcc agaaattctg cttggtgatg agtatgatgc acctgcagta gatatttgga      840

gtctgggagt gatccttttc atgttggtgt gtgggcagcc gccctttcaa gaagccaatg      900

acagtgaaac actgacaatg atcatggatt gcaaatatac agtaccatcc catgtgtcta      960

aagagtgtaa agacctaatc acacggatgc tacagagaga tcccaagaga agggcttctt     1020

tagaagagat tgaaaatcat ccttggcttc agggagtgga cccttcacca gctacaaagt     1080

ataacattcc ccttgtgtca tacaaaaatc tctcggaaga ggagcacaac agcatcattc     1140

agcgcatggt gcttggggac atagcggatc gagacgccat tgtagaagcc ctggaaacca     1200

acaggtataa ccatatcaca gccacatact tcctgctggc tgaaaggatc ctgagagaaa     1260

agcaagagaa agaaatacag accagatctg caagcccgag caatatcaag gcccagttta     1320

ggcagtcatg gccaaccaaa attgatgtac cccaggacct tgaggatgac ctcacggcca     1380

ctcctttgtc ccacgcgact gtccctcagt ctcctgctcg ggctgctgac agtgtcctca     1440

atggccacag gagcaaaggc ctgtgtgact cagctaagaa agatgacctc cctgagttgg     1500

ctggaccagc actctctacg gtgccacccg caagcttaaa acccacagcc agtgggcgga     1560

agtgtctgtt cagggtggaa gaagatgaag aggaagatga ggaggacaag aaacccatgt     1620

ccctctcaac acaagtggtt ttgcgccgga agccatctgt aaccaaccgc ctgacatcca     1680

ggaagagtgc gcccgtcctc aaccagatct ttgaggaagg ggaatctgac gatgagtttg     1740

acatggatga gaatctgcct cccaagttga gcaggttaaa gatgaatata gcttctccag     1800

gtacagttca caaacgctac caccggagga aaagtcaggg ccggggctcc agctgcagta     1860

gttcggagac cagtgatgat gattctgaaa gccggcggcg gctcgataaa gatagcgggt     1920

tcacctactc ctggcaccga cgggatagca gcgaggggcc ccctggcagt gagggggatg     1980

gcgggggcca gagcaagcca agcaatgcca gtggaggggt ggacaaggcc agccccagtg     2040

agaacaatgc tggtgggggc agtccctcca gcggctcggg tggcaacccc accaatacat     2100

cgggtaccac acgccgctgt gccggcccca gcaactccat gcagctggcc tctcgcagtg     2160

ctggggagct cgttgagagc ctcaaactca tgagcctctg cctcggctcc cagcttcatg     2220

ggagcaccaa gtacattatt gatccacaga atggcttgtc attttccagt gtgaaagtcc     2280

aagagaaatc tacgtggaaa atgtgcatta gctccacagg gaatgcaggg caggtccctg     2340

cagtgggcgg cataaagttt ttctctgacc acatggcaga taccaccact gaattggaac     2400

ggataaagag caagaacctg aaaaataacg tgctgcagct acctctgtgc gaaaagacca     2460

tctctgtgaa catccagcgg aaccctaagg aggggctgct gtgcgcatcc agcccagcca     2520

gctgttgcca tgtcatctga ctgtggcccc atctggccgc tagcacgctt cctgctcaga     2580

gcagtgaaga ccggctcact tcactgttcc atttggtttt actattttaa agtgggcgtt     2640

aggagcaatt atttattacc tttccatttg ttcgcctgat gatgtgacaa tgcatggtct     2700

ttgtgcatgc tgctagacac ttttctttcc cagccgaaaa gcctattatg taatttttac     2760

attcataatt ttaatgtgga tgatcaggat taaatcaaga tatatatctg gaacctctta     2820

taaatggagc acttagaaat ttgttgttct gcacttaacc tagagagaga aaaaatgctt     2880

ttctttgtga aaaatctgaa ttcctgtcct gaccttctgt gatgtggaaa ccctaggctc     2940

tgagacacac tctctggtgt ctgagacaga accaaagcaa taacgttgtg atgcccacag     3000

gcctggagcc agctagcgac cttgtgccgc ccagctgtcc atggcccgtg cagagcagag     3060

gacagtgagt gtctgcactg agaaccttaa accacagttg aacataccca cacctgtttg     3120

tcttaagcta tagtgtaaaa acaaagtttg ggctctgaaa atttaactga aaaagatttc     3180

cttgtttttg taataggtga gataaagtac ttagatttat aaggcagctt cccctgtagt     3240

gataaattac aagcagacaa tcttattttg taatgtgatg aagtgatgat gtcttaactc     3300

tacttagaga gtgtatgtct gtctaacaga acaaaaagat gctctgtgta aattccttcc     3360

tgtagggcac actgcaggat ttccatgtag atagaagaac tatagggcct agtacagaag     3420

gtgcacacaa atgttggcaa agtcaaaacc ccatgaatta aaacctactg gaatttggtt     3480

tttaggagtt tggtaattag attatctctt ttgttatttt cattcagtta tatcctttgg     3540

ctcagctagc tttgaaattg gctgatgaaa aaatatacat aaaagggtaa aattcacaca     3600

tacagcaaac aaaaatgcac aaagcctgct tcgtaacttt tttttctgga attgtttttc     3660

actttgcctt tttctgccaa aacaataatc aaagaactct tgctttaacc tattcctgta     3720

caaagactgt ttttgaccag ataatcatct gttgtggcat tctatcttgt aggacactgt     3780

atattgcaaa ttgctgatta tggaaggggc cagttgctgt tttttcatgc agtgccctgg     3840

gagtcttaaa agcagtgctt agcaacattg gtgatagcat gtggctggga cccagggccc     3900

ttccccactc ttcagccccg agtcatgtgt ctgaggtgac ggactgagac gcatctggtc     3960

ctgtaattca gagagtgggc acatcaccaa agaactgcat tgctgtggtc actgtttctt     4020

caagtacaca ctgactctgc tactttagga taaatatatt ttactcagaa ctctgaattt     4080

cacagtatac ttactaaact aagtaaaaat gatacttaaa atacttattt tactttctag     4140

acctaggcta gatgttttaa gctacagctc tagttcattg tgatatttat aatttgaaag     4200

ctatgagaat agatgtgtgg gtgaagccat agaacatatt tgcttgaaat tcttgagcag     4260

ggatcttata aagggccaga aataagatgt gtggttcaca tagatagtga gcgtaacatc     4320

tgtattaaac ataggagaga agtttataaa gggcattggc aataaactct ttgttgcagc     4380

tgttttccaa gcagtgtaaa tactttttcc tgtgattatg tatagccttg gaatggcacc     4440

ttttaactaa cccatatgtg tttggtttca atggtttttt atattcagat gtatatatgg     4500

tgctcacttt aggatcagca gtgttgacca tttatgctgc atagctgtat tatagcctta     4560

ttagttgtgt ggttgaccct tggggtatac aaatgtcagt ctgagtggtg tcttactcct     4620

ttgtttataa gtgaatgatt gtgcatgttt tgtatgtcat agtatgtcgt cacataaaag     4680

ggagggagcg aaaaaccatt acattaagat aatattggac caaactactt acttgctcta     4740

aacagttact tgtacccctt aacctgtctt caaaagttgc atatagttac agtagtgtat     4800

aaattaaata ttgtggaaaa acagtcttgt atttttctgt atgtgtgtat atatatataa     4860

ttatgtactt ctggcaattc tatctgtatt taaagatgtg acaatcttga caccaatttt     4920

aagaatagct gtgagaccga attaaagata atccctacca agtgaaaatt gatgtgtgtt     4980

aagagggtac agaattatca actgatttgg tcagttgctt ccaatgctgg ttgatttccc     5040

tcattgtgta aacattgaca ggtatgtgac aaatgggaaa aaaaatccaa ataataaagt     5100

gacatattgg tgttcagcaa tataaa                                          5126


<210> 10
<211> 765
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Gly Phe Lys Arg Gly Tyr Asp Gly Lys Ile Ala Gly Leu Tyr 
1               5                   10                  15      


Asp Leu Asp Lys Thr Leu Gly Arg Gly His Phe Ala Val Val Lys Leu 
            20                  25                  30          


Ala Arg His Val Phe Thr Gly Glu Lys Val Ala Val Lys Val Ile Asp 
        35                  40                  45              


Lys Thr Lys Leu Asp Thr Leu Ala Thr Gly His Leu Phe Gln Glu Val 
    50                  55                  60                  


Arg Cys Met Lys Leu Val Gln His Pro Asn Ile Val Arg Leu Tyr Glu 
65                  70                  75                  80  


Val Ile Asp Thr Gln Thr Lys Leu Tyr Leu Ile Leu Glu Leu Gly Asp 
                85                  90                  95      


Gly Gly Asp Met Phe Asp Tyr Ile Met Lys His Glu Glu Gly Leu Asn 
            100                 105                 110         


Glu Asp Leu Ala Lys Lys Tyr Phe Ala Gln Ile Val His Ala Ile Ser 
        115                 120                 125             


Tyr Cys His Lys Leu His Val Val His Arg Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Val Val Phe Phe Glu Lys Gln Gly Leu Val Lys Leu Thr Asp Phe Gly 
145                 150                 155                 160 


Phe Ser Asn Lys Phe Gln Pro Gly Lys Lys Leu Thr Thr Ser Cys Gly 
                165                 170                 175     


Ser Leu Ala Tyr Ser Ala Pro Glu Ile Leu Leu Gly Asp Glu Tyr Asp 
            180                 185                 190         


Ala Pro Ala Val Asp Ile Trp Ser Leu Gly Val Ile Leu Phe Met Leu 
        195                 200                 205             


Val Cys Gly Gln Pro Pro Phe Gln Glu Ala Asn Asp Ser Glu Thr Leu 
    210                 215                 220                 


Thr Met Ile Met Asp Cys Lys Tyr Thr Val Pro Ser His Val Ser Lys 
225                 230                 235                 240 


Glu Cys Lys Asp Leu Ile Thr Arg Met Leu Gln Arg Asp Pro Lys Arg 
                245                 250                 255     


Arg Ala Ser Leu Glu Glu Ile Glu Asn His Pro Trp Leu Gln Gly Val 
            260                 265                 270         


Asp Pro Ser Pro Ala Thr Lys Tyr Asn Ile Pro Leu Val Ser Tyr Lys 
        275                 280                 285             


Asn Leu Ser Glu Glu Glu His Asn Ser Ile Ile Gln Arg Met Val Leu 
    290                 295                 300                 


Gly Asp Ile Ala Asp Arg Asp Ala Ile Val Glu Ala Leu Glu Thr Asn 
305                 310                 315                 320 


Arg Tyr Asn His Ile Thr Ala Thr Tyr Phe Leu Leu Ala Glu Arg Ile 
                325                 330                 335     


Leu Arg Glu Lys Gln Glu Lys Glu Ile Gln Thr Arg Ser Ala Ser Pro 
            340                 345                 350         


Ser Asn Ile Lys Ala Gln Phe Arg Gln Ser Trp Pro Thr Lys Ile Asp 
        355                 360                 365             


Val Pro Gln Asp Leu Glu Asp Asp Leu Thr Ala Thr Pro Leu Ser His 
    370                 375                 380                 


Ala Thr Val Pro Gln Ser Pro Ala Arg Ala Ala Asp Ser Val Leu Asn 
385                 390                 395                 400 


Gly His Arg Ser Lys Gly Leu Cys Asp Ser Ala Lys Lys Asp Asp Leu 
                405                 410                 415     


Pro Glu Leu Ala Gly Pro Ala Leu Ser Thr Val Pro Pro Ala Ser Leu 
            420                 425                 430         


Lys Pro Thr Ala Ser Gly Arg Lys Cys Leu Phe Arg Val Glu Glu Asp 
        435                 440                 445             


Glu Glu Glu Asp Glu Glu Asp Lys Lys Pro Met Ser Leu Ser Thr Gln 
    450                 455                 460                 


Val Val Leu Arg Arg Lys Pro Ser Val Thr Asn Arg Leu Thr Ser Arg 
465                 470                 475                 480 


Lys Ser Ala Pro Val Leu Asn Gln Ile Phe Glu Glu Gly Glu Ser Asp 
                485                 490                 495     


Asp Glu Phe Asp Met Asp Glu Asn Leu Pro Pro Lys Leu Ser Arg Leu 
            500                 505                 510         


Lys Met Asn Ile Ala Ser Pro Gly Thr Val His Lys Arg Tyr His Arg 
        515                 520                 525             


Arg Lys Ser Gln Gly Arg Gly Ser Ser Cys Ser Ser Ser Glu Thr Ser 
    530                 535                 540                 


Asp Asp Asp Ser Glu Ser Arg Arg Arg Leu Asp Lys Asp Ser Gly Phe 
545                 550                 555                 560 


Thr Tyr Ser Trp His Arg Arg Asp Ser Ser Glu Gly Pro Pro Gly Ser 
                565                 570                 575     


Glu Gly Asp Gly Gly Gly Gln Ser Lys Pro Ser Asn Ala Ser Gly Gly 
            580                 585                 590         


Val Asp Lys Ala Ser Pro Ser Glu Asn Asn Ala Gly Gly Gly Ser Pro 
        595                 600                 605             


Ser Ser Gly Ser Gly Gly Asn Pro Thr Asn Thr Ser Gly Thr Thr Arg 
    610                 615                 620                 


Arg Cys Ala Gly Pro Ser Asn Ser Met Gln Leu Ala Ser Arg Ser Ala 
625                 630                 635                 640 


Gly Glu Leu Val Glu Ser Leu Lys Leu Met Ser Leu Cys Leu Gly Ser 
                645                 650                 655     


Gln Leu His Gly Ser Thr Lys Tyr Ile Ile Asp Pro Gln Asn Gly Leu 
            660                 665                 670         


Ser Phe Ser Ser Val Lys Val Gln Glu Lys Ser Thr Trp Lys Met Cys 
        675                 680                 685             


Ile Ser Ser Thr Gly Asn Ala Gly Gln Val Pro Ala Val Gly Gly Ile 
    690                 695                 700                 


Lys Phe Phe Ser Asp His Met Ala Asp Thr Thr Thr Glu Leu Glu Arg 
705                 710                 715                 720 


Ile Lys Ser Lys Asn Leu Lys Asn Asn Val Leu Gln Leu Pro Leu Cys 
                725                 730                 735     


Glu Lys Thr Ile Ser Val Asn Ile Gln Arg Asn Pro Lys Glu Gly Leu 
            740                 745                 750         


Leu Cys Ala Ser Ser Pro Ala Ser Cys Cys His Val Ile 
        755                 760                 765 


<210> 11
<211> 10
<212> PRT
<213> Adeno-associated virus

<400> 11
Leu Ala Asp Gln Asp Tyr Thr Lys Thr Ala 
1               5                   10  


