
                                SEQUENCE LISTING

<110> Janssen Pharmaceuticals, Inc.

<120> USE OF OLIGONUCLEOTIDES FOR INDIVIDUALS WITH HEPATIC IMPAIRMENT

<130> 16500-20012.40

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> US 63/194,148
<151> 2021-05-27

<150> US 63/138,322
<151> 2021-01-15

<160> 334

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent antisense strand modified sequence

<400> 1
agaaaauuga gagaagucca c                                           21

<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent antisense strand modified sequence

<400> 2
agaaaauuga gagaagucca c                                           21

<210> 3
<211> 23
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent antisense strand modified sequence

<400> 3
agaaaauuga gagaagucca cuu                                         23

<210> 4
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent antisense strand modified sequence

<400> 4
agaaaauuga gagaagucca cc                                          22

<210> 5
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent antisense strand unmodified sequence

<400> 5
agaaaauuga gagaagucca c                                           21

<210> 6
<211> 23
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent antisense strand unmodified sequence

<400> 6
agaaaauuga gagaagucca cuu                                         23

<210> 7
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent antisense strand unmodified sequence

<400> 7
agaaaauuga gagaagucca cc                                          22

<210> 8
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent antisense strand modified sequence

<400> 8
uaccaauuua ugccuacagc g                                           21

<210> 9
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent antisense strand unmodified sequence

<400> 9
uaccaauuua ugccuacagc g                                           21

<210> 10
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand modified sequence

<400> 10
guggacuucu cucaauuuuc u                                           21

<210> 11
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand modified sequence

<400> 11
guggacuucu cucaauuuuc u                                           21

<210> 12
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand modified sequence

<400> 12
gguggacuuc ucucaauuuu cu                                          22

<210> 13
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand modified sequence

<400> 13
guggacuucu cucaauuuuc u                                           21

<210> 14
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand unmodified sequence

<400> 14
guggacuucu cucaauuuuc u                                           21

<210> 15
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand unmodified sequence

<400> 15
gguggacuuc ucucaauuuu cu                                          22

<210> 16
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand modified sequence

<400> 16
cgcuguaggc auaaauuggu a                                           21

<210> 17
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand modified sequence

<400> 17
cgcuguaggc auaaauuggu a                                           21

<210> 18
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand modified sequence

<400> 18
cgcuguaggc auaaauuggu a                                           21

<210> 19
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> HBV RNAi Agent sense strand unmodified sequence

<400> 19
cgcuguaggc auaaauuggu a                                           21

<210> 20
<400> 20
000

<210> 21
<400> 21
000

<210> 22
<400> 22
000

<210> 23
<400> 23
000

<210> 24
<400> 24
000

<210> 25
<400> 25
000

<210> 26
<400> 26
000

<210> 27
<400> 27
000

<210> 28
<400> 28
000

<210> 29
<400> 29
000

<210> 30
<400> 30
000

<210> 31
<400> 31
000

<210> 32
<400> 32
000

<210> 33
<400> 33
000

<210> 34
<400> 34
000

<210> 35
<400> 35
000

<210> 36
<400> 36
000

<210> 37
<400> 37
000

<210> 38
<400> 38
000

<210> 39
<400> 39
000

<210> 40
<400> 40
000

<210> 41
<400> 41
000

<210> 42
<400> 42
000

<210> 43
<400> 43
000

<210> 44
<400> 44
000

<210> 45
<400> 45
000

<210> 46
<400> 46
000

<210> 47
<400> 47
000

<210> 48
<400> 48
000

<210> 49
<400> 49
000

<210> 50
<400> 50
000

<210> 51
<400> 51
000

<210> 52
<400> 52
000

<210> 53
<400> 53
000

<210> 54
<400> 54
000

<210> 55
<400> 55
000

<210> 56
<400> 56
000

<210> 57
<400> 57
000

<210> 58
<400> 58
000

<210> 59
<400> 59
000

<210> 60
<400> 60
000

<210>  61
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  61
uaccaauuua ugccuacagg ccuuau                                        26


<210>  62
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  62
uaccaauuua ugccuacagg ccu                                           23

<210>  63
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  63
uaccaauuua ugccuacagg ccu                                           23

<210>  64
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  64
uaccaauuua ugccuacagg c                                             21

<210>  65
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  65
ugugaagcga agugcacacu u                                             21


<210>  66
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  66
uaccaauuua ugccuacagc cuccgc                                        26

<210>  67
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  67
uaccaauuua ugccuacagc cuccgc                                        26

<210>  68
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  68
uaccaauuua ugccuacagu u                                             21

<210>  69
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  69
uaccaauuua ugccuacagg c                                             21

<210>  70
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  70
uaccaauuua ugccuacagg c                                             21

<210>  71
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  71
uaccaauuua ugccuacagu u                                             21

<210>  72
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  72
auugagagaa guccaccacg a                                             21

<210>  73
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  73
auugagagaa guccaccacg a                                             21

<210>  74
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  74
auugagagaa guccaccacu u                                             21

<210>  75
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  75
uuugagagaa guccaccacg a                                             21

<210>  76
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  76
aauugagaga aguccaccac g                                             21


<210>  77
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  77
aauugagaga aguccaccac g                                             21


<210>  78
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  78
aauugagaga aguccaccau u                                             21


<210>  79
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  79
uauugagaga aguccaccac g                                             21 

<210>  80
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  80
uaccaauuua ugccuacagg u                                             21 

<210>  81
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  81
uaccaauuua ugccuacagu u                                             21 

<210>  82
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  82
uaccaauuua ugccuacagc c                                             21 

<210>  83
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  83
uaccaauuua ugccuacagc cuu                                           23 


<210>  84
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  84
uaccaauuua ugccuacagc cuc                                           23 

<210>  85
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  85
uaccaauuua ugccuacagc c                                             21 

<210>  86
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  86
uaccaauuua ugccuacagc cuu                                           23 

<210>  87
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  87
uaccaauuua ugccuacagc cuc                                           23

<210>  88
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  88
auugagagaa guccaccacu u                                             21 

<210>  89
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  89
uuugagagaa guccaccacu u                                             21 

<210>  90
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  90
auugagagaa guccaccacg guu                                           23

<210>  91
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  91
auugagagaa guccaccacg guu                                           23

<210>  92
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  92
auugagagaa guccaccacg agu                                           23

<210>  93
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  93
uauugagaga aguccaccac g                                             21


<210>  94
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223> HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  94
uauugagaga aguccaccac g                                             21

<210>  95
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  95
uauugagaga aguccaccac guu                                           23

<210>  96
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  96
uauugagaga aguccaccac gag                                           23

<210>  97
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  97
uauugagaga aguccaccac gag                                           23

<210>  98
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  98
uauugagaga aguccaccac ga                                            22

<210>  99
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  99
uauugagaga aguccaccac ga                                            22


<210>  100
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  100
agaaaauuga gagaagucca c                                             21

<210>  101
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  101
uaccaauuua ugccuacagu u                                             21


<210>  102
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  102
uaccaauuua ugccuacagc c                                             21


<210>  103
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  103
uaccaauuua ugccuacagc uu                                            22


<210>  104
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  104
uaccaauuua ugccuacagc cu                                            22

<210>  105
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  105
uaccaauuua ugccuacagc cuu                                           23


<210>  106
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  106
uaccaauuua ugccuacagc cuc                                           23

<210>  107
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  107
uaccaauuua ugccuacagu u                                             21


<210>  108
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  108
uauugagaga aguccaccac g                                             21

<210>  109
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  109
uauugagaga aguccaccau u                                             21

<210>  110
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  110
uauugagaga aguccaccac g                                             21

<210>  111
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  111
uauugagaga aguccaccac uu                                            22

<210>  112
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  112
uauugagaga aguccaccac ga                                            22

<210>  113
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  113
uauugagaga aguccaccac g                                             21

<210>  114
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  114
uuugagagaa guccaccacu u                                             21

<210>  115
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  115
uuugagagaa guccaccacg a                                             21

<210>  116
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  116
uuugagagaa guccaccacg uu                                            22

<210>  117
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  117
uuugagagaa guccaccacg ag                                            22


<210>  118
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  118
uuugagagaa guccaccacu u                                             21

<210>  119
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  119
uauugagaga aguccaccac uu                                            22

<210>  120
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  120
uauugagaga aguccaccac uu                                            22

<210>  121
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  121
uauugagaga aguccaccac guu                                           23

<210>  122
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  122
uauugagaga aguccaccac uu                                            22

<210>  123
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  123
uauugagaga aguccaccac gag                                           23

<210>  124
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  124
uauugagaga aguccaccac uu                                            22

<210>  125
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  125
agaaaauuga gagaaguccu u                                             21

<210>  126
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  126
agaaaauuga gagaagucca c                                             21

<210>  127
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  127
agaaaauuga gagaagucca cuu                                           23

<210>  128
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  128
agaaaauuga gagaagucca cc                                            22

<210>  129
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  129
ugaaaauuga gagaaguccu u                                             21

<210>  130
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  130
ugaaaauuga gagaagucca c                                             21

<210>  131
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  131
accaauuuau gccuacagcu u                                             21

<210>  132
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  132
accaauuuau gccuacagcc uu                                            22

<210>  133
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  133
accaauuuau gccuacagcc uc                                            22

<210>  134
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  134
uccaauuuau gccuacagcu u                                             21

<210>  135
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  135
uccaauuuau gccuacagcc uu                                            22

<210>  136
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  136
uaccaauuua ugccuacagc c                                             21

<210>  137
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  137
uaccaauuua ugccuacagc c                                             21

<210>  138
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  138
uaccaauuua ugccuacagc c                                             21

<210>  139
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  139
uaccaauuua ugccuacagc u                                             21

<210>  140
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  140
uaccaauuua ugccuacagc g                                             21

<210>  141
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  141
aaccaauuua ugccuacagc c                                             21

<210>  142
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  142
uaccaauuua ugccuacagu u                                             21

<210>  143
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  143
uaccaauuua ugccuacagc c                                             21

<210>  144
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  144
accaauuuau gccuacagcc u                                             21

<210>  145
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  145
uccaauuuau gccuacagcc u                                             21

<210>  146
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  146
accaauuuau gccuacagcc g                                             21

<210>  147
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  147
uccaauuuau gccuacagcc g                                             21

<210>  148
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 3

<400>  148
uaccaauuua ugccuacagg g                                             21


<210>  149
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  149
uaccaauuua ugccuacagg ccuuau                                        26

<210>  150
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  150
uaccaauuua ugccuacagg ccu                                           23

<210>  151
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223> HBV RNAi Agent antisense strand unmodified sequence

<400>  151
uaccaauuua ugccuacagg c                                             21

<210>  152
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  152
ugugaagcga agugcacacu u                                             21

<210>  153
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  153
uaccaauuua ugccuacagc cuccgc                                        26

<210>  154
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  154
uaccaauuua ugccuacagu u                                             21

<210>  155
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  155
auugagagaa guccaccacg a                                             21

<210>  156
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  156
auugagagaa guccaccacu u                                             21

<210>  157
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  157
uuugagagaa guccaccacg a                                             21

<210>  158
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  158
aauugagaga aguccaccac g                                             21

<210>  159
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  159
aauugagaga aguccaccau u                                             21


<210>  160
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  160
uauugagaga aguccaccac g                                             21

<210>  161
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  161
uaccaauuua ugccuacagg u                                             21

<210>  162
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  162
uaccaauuua ugccuacagc c                                             21

<210>  163
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  163
uaccaauuua ugccuacagc cuu                                           23

<210>  164
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  164
uaccaauuua ugccuacagc cuc                                           23

<210>  165
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  165
uuugagagaa guccaccacu u                                             21

<210>  166
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  166
auugagagaa guccaccacg guu                                           23

<210>  167
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  167
auugagagaa guccaccacg agu                                           23

<210>  168
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  168
uauugagaga aguccaccac guu                                           23

<210>  169
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  169
uauugagaga aguccaccac gag                                           23

<210>  170
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  170
uauugagaga aguccaccac ga                                            22

<210>  171
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  171
agaaaauuga gagaagucca c                                             21

<210>  172
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  172
uaccaauuua ugccuacagc uu                                            22

<210>  173
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  173
uaccaauuua ugccuacagc cu                                            22

<210>  174
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  174
uauugagaga aguccaccau u                                             21

<210>  175
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  175
uauugagaga aguccaccac uu                                            22

<210>  176
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  176
uuugagagaa guccaccacg uu                                            22

<210>  177
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  177
uuugagagaa guccaccacg ag                                            22

<210>  178
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  178
agaaaauuga gagaaguccu u                                             21

<210>  179
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  179
agaaaauuga gagaagucca cuu                                           23

<210>  180
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  180
agaaaauuga gagaagucca cc                                            22

<210>  181
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  181
ugaaaauuga gagaagucca c                                             21

<210>  182
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  182
accaauuuau gccuacagcu u                                             21

<210>  183
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  183
accaauuuau gccuacagcc uu                                            22

<210>  184
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  184
accaauuuau gccuacagcc uc                                            22

<210>  185
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  185
uccaauuuau gccuacagcu u                                             21

<210>  186
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  186
uccaauuuau gccuacagcc uu                                            22

<210>  187
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  187
uaccaauuua ugccuacagc u                                             21

<210>  188
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  188
uaccaauuua ugccuacagc g                                             21

<210>  189
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  189
aaccaauuua ugccuacagc c                                             21


<210>  190
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  190
accaauuuau gccuacagcc u                                             21

<210>  191
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  191
uccaauuuau gccuacagcc u                                             21

<210>  192
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  192
accaauuuau gccuacagcc g                                             21

<210>  193
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  193
uccaauuuau gccuacagcc g                                             21
 
<210>  194
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand unmodified sequence

<400>  194
uaccaauuua ugccuacagg g                                             21

<210>  195
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  195
uugccuguag gcauaaauug guaut                                         25

<210>  196
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  196
uauaugccug uaggcauaaa uuggua                                        26

<210>  197
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  197
gcggaggcug uaggcauaaa uuggta                                        26

<210>  198
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  198
cuguaggcau aaauugguau u                                             21

<210>  199
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  199
gccuguaggc auaaauuggu a                                             21

<210>  200
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  200
gccuguaggc auaaauuggu a                                             21

<210>  201
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  201
gccuguaggc auaaauuggu a                                             21

<210>  202
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  202
gccuguaggc auaaauuggt a                                             21

<210>  203
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  203
aacuguaggc auaaauuggu a                                             21

<210>  204
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  204
ucguggugga cuucucucaa u                                             21

<210>  205
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  205
aaguggugga cuucucucaa u                                             21
 
<210>  206
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  206
ucguggugga cuucucucaa t                                             21

<210>  207
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  207
cgugguggac uucucucaau u                                             21

<210>  208
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  208
aaugguggac uucucucaau u                                             21

<210>  209
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  209
cgugguggac uucucucaat t                                             21

<210>  210
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  210
ggacuucucu caauuuucua a                                             21

<210>  211
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  211
cgugguggac uucucucaau a                                             21

<210>  212
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  212
ucguggugga cuucucucaa a                                             21

<210>  213
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  213
accuguaggc auaaauuggu a                                             21

<210>  214
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  214
cuguaggcau aaauuggua                                                19

<210>  215
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  215
cuguaggcau aaauuggua                                                19

<210>  216
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  216
cuguaggcau aaauuggua                                                19

<210>  217
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  217
acuguaggca uaaauuggua                                               20

<210>  218
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  218
ggcuguaggc auaaauuggu a                                             21

<210>  219
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  219
aaguggugga cuucucucaa u                                             21

<210>  220
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  220
aaguggugga cuucucucaa a                                             21

<210>  221
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  221
ccguggugga cuucucucaa u                                             21

<210>  222
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  222
ccguggugga cuucucucaa u                                             21

<210>  223
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  223
cucguggugg acuucucuca au                                            22

<210>  224
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  224
gugguggacu ucucucaau                                                19

<210>  225
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  225
gugguggacu ucucucaauu u                                             21

<210>  226
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  226
ucguggugga cuucucucaa uu                                            22

<210>  227
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  227
ugguggacuu cucucaauu                                                19

<210>  228
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  228
ugguggacuu cucucaauu                                                19

<210>  229
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  229
guggacuucu cucaauuuuc u                                             21

<210>  230
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  230
cuguaggcau aaauugguau u                                             21

<210>  231
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  231
gcuguaggca uaaauuggua uu                                            22

<210>  232
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  232
ggcuguaggc auaaauuggu auu                                           23

<210>  233
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  233
aacuguaggc auaaauuggu auu                                           23

<210>  234
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  234
ugguggacuu cucucaauau u                                             21

<210>  235
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  235
gugguggacu ucucucaaua uu                                            22

<210>  236
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  236
aaugguggac uucucucaau auu                                           23

<210>  237
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  237
cgugguggac uucucucaau auu                                           23

<210>  238
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  238
cgugguggac uucucucaau a                                             21

<210>  239
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  239
aaguggugga cuucucucaa u                                             21

<210>  240
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  240
gugguggacu ucucucaaau u                                             21

<210>  241
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  241
cgugguggac uucucucaaa uu                                            22

<210>  242
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  242
aaguggugga cuucucucaa auu                                           23

<210>  243
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  243
ucguggugga cuucucucaa auu                                           23

<210>  244
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  244
gugguggacu ucucucaaua uu                                            22

<210>  245
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  245
cgugguggac uucucucaau auu                                           23

<210>  246
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  246
cucguggugg acuucucuca aua                                           23

<210>  247
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  247
cucguggugg acuucucuca auauu                                         25

<210>  248
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  248
ggcuguaggc auaaauuggu a                                             21

<210>  249
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  249
gaggcuguag gcauaaauug gua                                           23

<210>  250
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  250
gaggcuguag gcauaaauug guauu                                         25

<210>  251
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  251
ggacuucucu caauuuucu                                                19

<210>  252
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  252
guggacuucu cucaauuuuc u                                             21

<210>  253
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  253
gguggacuuc ucucaauuuu cu                                            22

<210>  254
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  254
ggacuucucu caauuuuca                                                19

<210>  255
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  255
ggacuucucu caauuuuca                                                19

<210>  256
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  256
gcuguaggca uaaauuggu                                                19

<210>  257
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  257
ggcuguaggc auaaauuggu                                               20

<210>  258
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  258
gaggcuguag gcauaaauug gu                                            22

<210>  259
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  259
gcuguaggca uaaauugga                                                19

<210>  260
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  260
ggcuguaggc auaaauugga                                               20

<210>  261
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  261
agcuguaggc auaaauuggu a                                             21

<210>  262
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  262
cgcuguaggc auaaauuggu a                                             21

<210>  263
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  263
ggcuguaggc auaaauuggu u                                             21

<210>  264
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  264
cuguaggcau aaauugguau u                                             21
 
<210>  265
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  265
cuguaggcau aaauugguau u                                             21

<210>  266
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  266
aggcuguagg cauaaauugg u                                             21

<210>  267
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  267
aggcuguagg cauaaauugg a                                             21

<210>  268
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  268
cggcuguagg cauaaauugg u                                             21

<210>  269
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  269
cggcuguagg cauaaauugg a                                             21

<210>  270
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  270
cccuguaggc auaaauuggu a                                             21

<210>  271
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  271
cgcuguaggc auaaauuggu a                                             21

<210>  272
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  272
cccuguaggc auaaauuggu a                                             21

<210>  273
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  273
guggacuucu cucaauuuuc u                                             21

<210>  274
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent antisense strand modified sequence as indicated in
       Table 4

<400>  274
cgcuguaggc auaaauuggu a                                             21

<210>  275
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  275
uugccuguag gcauaaauug guaut                                         25

<210>  276
<211>  26
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  276
uauaugccug uaggcauaaa uuggua                                        26

<210>  277
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  277
gcggaggcug uaggcauaaa uuggta                                        26

<210>  278
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  278
cuguaggcau aaauugguau u                                             21

<210>  279
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  279
gccuguaggc auaaauuggu a                                             21

<210>  280
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  280
gccuguaggc auaaauuggt a                                             21

<210>  281
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  281
aacuguaggc auaaauuggu a                                             21

<210>  282
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  282 
ucguggugga cuucucucaa u                                             21

<210>  283
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  283
aaguggugga cuucucucaa u                                             21

<210>  284
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  284
ucguggugga cuucucucaa t                                             21

<210>  285
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  285
cgugguggac uucucucaau u                                             21

<210>  286
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  286
aaugguggac uucucucaau u                                             21

<210>  287
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  287
cgugguggac uucucucaat t                                             21

<210>  288
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  288
ggacuucucu caauuuucua a                                             21

<210>  289
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  289
cgugguggac uucucucaau a                                             21

<210>  290
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  290
ucguggugga cuucucucaa a                                             21

<210>  291
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  291
accuguaggc auaaauuggu a                                             21

<210>  292
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  292
cuguaggcau aaauuggua                                                19

<210>  293
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  293
acuguaggca uaaauuggua                                               20

<210>  294
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  294
ggcuguaggc auaaauuggu a                                             21

<210>  295
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  295
aaguggugga cuucucucaa a                                             21
 
<210>  296
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  296
ccguggugga cuucucucaa u                                             21

<210>  297
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  297
cucguggugg acuucucuca au                                            22

<210>  298
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  298
gugguggacu ucucucaau                                                19

<210>  299
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  299
gugguggacu ucucucaauu u                                             21

<210>  300
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  300
ucguggugga cuucucucaa uu                                            22

<210>  301
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  301
ugguggacuu cucucaauu                                                19

<210>  302
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  302
guggacuucu cucaauuuuc u                                             21

<210>  303
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  303
gcuguaggca uaaauuggua uu                                            22

<210>  304
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  304
ggcuguaggc auaaauuggu auu                                           23

<210>  305
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  305
aacuguaggc auaaauuggu auu                                           23

<210>  306
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  306
ugguggacuu cucucaauau u                                             21

<210>  307
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  307
gugguggacu ucucucaaua uu                                            22

<210>  308
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  308
aaugguggac uucucucaau auu                                           23

<210>  309
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  309
cgugguggac uucucucaau auu                                           23

<210>  310
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  310
gugguggacu ucucucaaau u                                             21

<210>  311
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  311
cgugguggac uucucucaaa uu                                            22

<210>  312
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  312
aaguggugga cuucucucaa auu                                           23

<210>  313
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  313
ucguggugga cuucucucaa auu                                           23

<210>  314
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  314
cucguggugg acuucucuca aua                                           23

<210>  315
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  315
cucguggugg acuucucuca auauu                                         25

<210>  316
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  316
gaggcuguag gcauaaauug gua                                           23

<210>  317
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  317
gaggcuguag gcauaaauug guauu                                         25

<210>  318
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  318
ggacuucucu caauuuucu                                                19

<210>  319
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  319
gguggacuuc ucucaauuuu cu                                            22

<210>  320
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  320
ggacuucucu caauuuuca                                                19

<210>  321
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  321
guggacuucu cucaauuuuc a                                             21

<210>  322
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  322
gcuguaggca uaaauuggu                                                19

<210>  323
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  323
ggcuguaggc auaaauuggu                                               20

<210>  324
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  324
gaggcuguag gcauaaauug gu                                            22

<210>  325
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  325
gcuguaggca uaaauugga                                                19

<210>  326
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  326
ggcuguaggc auaaauugga                                               20

<210>  327
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  327
agcuguaggc auaaauuggu a                                             21

<210>  328
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  328
cgcuguaggc auaaauuggu a                                             21

<210>  329
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  329
ggcuguaggc auaaauuggu u                                             21

<210>  330
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  330
aggcuguagg cauaaauugg u                                             21

<210>  331
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  331
aggcuguagg cauaaauugg a                                             21

<210>  332
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  332
cggcuguagg cauaaauugg u                                             21

<210>  333
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  333
cggcuguagg cauaaauugg a                                             21

<210>  334
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  HBV RNAi Agent sense strand unmodified sequence

<400>  334
cccuguaggc auaaauuggu a                                             21
 
