                      б

<110>  ϺҽҩƼ޹˾ż޹˾

<120>  GARP׿弰Ӧ

<130>  0134-PA-024

<160>  54

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 VH;1907hz0 VH

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Ala Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Val Thr Val Asp Lys Ser Ser Arg Ile Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 HCDR1;1907hz0 HCDR1;JYB1907hz18 HCDR1

<400>  2

Gly Tyr Thr Leu Ser Asn Tyr 
1               5           


<210>  3
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 HCDR2;JYB1907hz0 HCDR2;JYB1907hz18 HCDR2

<400>  3

Ala Pro Ser Asp Ser Glu 
1               5       


<210>  4
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 HCDR3;JYB1907hz0 HCDR3;JYB1907hz18 HCDR3

<400>  4

Gly Gly Phe Gly Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  5
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 H-FR1;1907hz0 H-FR1

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  6
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 H-FR2;1907hz0 H-FR2

<400>  6

Trp Met Tyr Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Ser Ile 
            


<210>  7
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 H-FR3;1907hz0 H-FR3

<400>  7

Thr His Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Val Thr Val Asp 
1               5                   10                  15      


Lys Ser Ser Arg Ile Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            20                  25                  30          


Asp Ser Ala Val Tyr Phe Cys Ala Arg 
        35                  40      


<210>  8
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 H-FR4;1907hz0 H-FR4

<400>  8

Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  9
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 VL;1907hz0 VL

<400>  9

Asp Ile Gln Met Thr Gln Ser Ser Ala Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Lys Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Gly Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 LCDR1;1907Hz0 LCDR1

<400>  10

Lys Ala Ser Asp His Ile Asn Lys Trp Leu Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 LCDR2;1907Hz0 LCDR2

<400>  11

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 LCDR3;1907Hz0 VL LCDR3;JYB1907hz18 LCDR3

<400>  12

Gln Gln Tyr Trp Thr Thr Pro Tyr Thr 
1               5                   


<210>  13
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 L-FR1;1907hz0 L-FR1

<400>  13

Asp Ile Gln Met Thr Gln Ser Ser Ala Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys 
            20              


<210>  14
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 L-FR2;1907hz0 L-FR2;1907hz18 L-FR2

<400>  14

Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile Ser 
1               5                   10                  15  


<210>  15
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 L-FR3; 1907Hz0 L-FR3

<400>  15

Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr 
1               5                   10                  15      


Leu Ser Ile Thr Gly Leu Gln Thr Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  16
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 L-FR4;1907Hz0 L-FR4

<400>  16

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  17
<211>  327
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  18
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  18

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  19
<211>  450
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1907hz0

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Ala Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Val Thr Val Asp Lys Ser Ser Arg Ile Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  20
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1907Hz0

<400>  20

Asp Ile Gln Met Thr Gln Ser Ser Ala Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Lys Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Gly Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  21
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1907hz18 VH

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Ala Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Thr Val Asp Lys Ser Thr Arg Ile Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  22
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1907Hz18 H-FR1

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  23
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1907Hz18 H-FR2

<400>  23

Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Ser Ile 
            


<210>  24
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1907Hz18 H-FR3

<400>  24

Thr His Tyr Asn Gln Lys Phe Gln Gly Arg Val Thr Val Thr Val Asp 
1               5                   10                  15      


Lys Ser Thr Arg Ile Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Phe Cys Ala Arg 
        35                  40      


<210>  25
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1907Hz18 H-FR4

<400>  25

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  26
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1907hz18 VL

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Asp His Ile Asn Lys Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1907hz18 LCDR1

<400>  27

Arg Ala Ser Asp His Ile Asn Lys Trp Leu Ala 
1               5                   10      


<210>  28
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1907hz18 LCDR2

<400>  28

Gly Ala Thr Ser Leu Glu Ser 
1               5           


<210>  29
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1907Hz18 L-FR1

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  30
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1907Hz18 L-FR3

<400>  30

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  31
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1907Hz18 L-FR4

<400>  31

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  32
<211>  450
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> JYB1907hz18

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Ala Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Thr Val Asp Lys Ser Thr Arg Ile Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  33
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> JYB1907hz18

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Asp His Ile Asn Lys Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  34
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 VH

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  35
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 HCDR1

<400>  35

Gly Phe Thr Phe Ser Asp Ser Trp Ile His 
1               5                   10  


<210>  36
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 HCDR2

<400>  36

Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  37
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 HCDR3

<400>  37

Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   


<210>  38
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 VL

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  39
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 LCDR1

<400>  39

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  40
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> PD-L1 LCDR2

<400>  40

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  41
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 LCDR3

<400>  41

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  42
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  43
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  44
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 LCDR1; 1907Hz0 VL LCDR1; JYB1907hz18 LCDR1ͨʽ

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = LysArg

<400>  44

Xaa Ala Ser Asp His Ile Asn Lys Trp Leu Ala 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 LCDR2; 1907Hz0 VL LCDR2; JYB1907hz18 LCDR2ͨʽ

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = SerThr

<400>  45

Gly Ala Thr Ser Leu Glu Xaa 
1               5           


<210>  46
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 H-FR1; 1907Hz0 H-FR1; 1907Hz18 H-FR1ͨʽ

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = LysVal

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = LeuVal

<400>  46

Gln Val Gln Leu Xaa Gln Ser Gly Ala Glu Xaa Xaa Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Ser 
            20                  25  


<210>  47
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 H-FR2; 1907Hz0 H-FR2; 1907Hz18 H-FR2ͨʽ

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = AlaArg

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = GlyIle

<400>  47

Trp Met Tyr Trp Val Xaa Gln Xaa Pro Xaa Gln Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Ser Ile 
            


<210>  48
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 H-FR3; 1907Hz0 H-FR3; 1907Hz18 H-FR3ͨʽ

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = SerThr

<400>  48

Thr His Tyr Asn Gln Lys Phe Xaa Xaa Arg Xaa Thr Val Thr Val Asp 
1               5                   10                  15      


Lys Ser Xaa Arg Ile Val Tyr Met Xaa Leu Ser Ser Leu Xaa Ser Glu 
            20                  25                  30          


Asp Xaa Ala Val Tyr Phe Cys Ala Arg 
        35                  40      


<210>  49
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 H-FR4; 1907Hz0 H-FR4; 1907Hz18 H-FR4ͨʽ

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = GlnThr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = MetThr

<400>  49

Trp Gly Xaa Gly Thr Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  50
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 VH; 1907Hz0 VH; JYB1907hz18 VHͨʽ

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = LysVal

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = AlaArg

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = GlyIle

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  Xaa = GlnThr

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa = MetThr

<400>  50

Gln Val Gln Leu Xaa Gln Ser Gly Ala Glu Xaa Xaa Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Xaa Gln Xaa Pro Xaa Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Ala Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Xaa Xaa Arg Xaa Thr Val Thr Val Asp Lys Ser Xaa Arg Ile Val Tyr 
65                  70                  75                  80  


Met Xaa Leu Ser Ser Leu Xaa Ser Glu Asp Xaa Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Xaa Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120             


<210>  51
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 VL; 1907Hz0 VL; JYB1907hz18 VLͨʽ

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = ThrTyr

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = GlySer

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = ProThr

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = PheVal

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = GlyGln

<400>  51

Asp Ile Gln Met Thr Gln Ser Xaa Xaa Xaa Leu Ser Xaa Ser Xaa Gly 
1               5                   10                  15      


Xaa Arg Val Thr Ile Thr Cys Xaa Ala Ser Asp His Ile Asn Lys Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Xaa Gly Xaa Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Xaa Ile Xaa Xaa Leu Gln Xaa 
65                  70                  75                  80  


Xaa Asp Xaa Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  52
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 L-FR1; 1907Hz0 L-FR1; 1907Hz18 L-FR1ͨʽ

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = ThrTyr

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AspGly

<400>  52

Asp Ile Gln Met Thr Gln Ser Xaa Xaa Xaa Leu Ser Xaa Ser Xaa Gly 
1               5                   10                  15      


Xaa Arg Val Thr Ile Thr Cys 
            20              


<210>  53
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 L-FR3; 1907Hz0 L-FR3; 1907Hz18 L-FR3ͨʽ

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = GlySer

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = ProThr

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = PheVal

<400>  53

Gly Xaa Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr 
1               5                   10                  15      


Leu Xaa Ile Xaa Xaa Leu Gln Xaa Xaa Asp Xaa Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  54
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  8H2D7B3 L-FR4; 1907Hz0 L-FR4; 1907Hz18 L-FR4ͨʽ

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = GlyGln

<400>  54

Phe Gly Xaa Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  



