                         SEQUENCE LISTING

<110>  Lantern Pharma Inc.
 
<120>  TREATMENT OF BRAIN METASTASES AND CNS METASTASES USING ILLUDINS 
       OR HYDROXYLUREAMETHYL ACYLFULVENE

<130>  197585-010181

<140>  PCT/US22/70126
<141>  2022-01-10

<150>  63/135,370
<151>  2021-01-08

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys Val Val Glu Ser Lys Asn Val Ala Leu Pro 
65                  70                  75                  80  


Lys Gly Thr Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile 
                85                  90                  95      


Ser Asp Gly Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr 
            100                 105                 110         


Ile Pro Leu Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr 
        115                 120                 125             


Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val Lys Gly Gly Glu Thr 
    130                 135                 140                 


Val Met Val Asn Ala Ala Ala Gly Ala Val Gly Ser Val Val Gly Gln 
145                 150                 155                 160 


Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly Ala Val Gly Ser Asp 
                165                 170                 175     


Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe Asp Val Val Phe Asn 
            180                 185                 190         


Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu Lys Lys Ala Ser Pro 
        195                 200                 205             


Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly Gly Glu Phe Ser Asn 
    210                 215                 220                 


Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg Ile Ala Ile Cys Gly 
225                 230                 235                 240 


Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu Pro Pro Gly Pro Pro 
                245                 250                 255     


Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met Glu Ala Phe Val Val 
            260                 265                 270         


Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala Leu Lys Asp Leu Leu 
        275                 280                 285             


Lys Trp Val Leu Glu Gly Lys Ile Gln Tyr Lys Glu Tyr Ile Ile Glu 
    290                 295                 300                 


Gly Phe Glu Asn Met Pro Ala Ala Phe Met Gly Met Leu Lys Gly Asp 
305                 310                 315                 320 


Asn Leu Gly Lys Thr Ile Val Lys Ala 
                325                 


<210>  2
<211>  2499
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Compliemental DNA sequence to mRNA

<400>  2
gcagtcccag ccgccttccc caggcagtgg aaccttcggg ctcctgagct tcaggatggt       60

tcgtactaag acatggaccc tgaagaagca ctttgttggc tatcctacta atagtgactt      120

tgagttgaag acagctgagc tcccaccctt aaaaaatgga gaggtcctgc ttgaagcttt      180

gttcctcacc gtggatccct acatgagagt ggcagccaaa agattgaagg aaggtgatac      240

aatgatgggg cagcaagtgg ccaaagttgt ggaaagtaaa aatgtagccc taccaaaagg      300

aactattgta ctggcttctc caggctggac aacgcactcc atttctgatg ggaaagatct      360

ggaaaagctg ctgacagagt ggccagacac aataccactg tctttggctc tggggacagt      420

tggcatgcca ggcctgactg cctactttgg cctacttgaa atctgtggtg tgaagggtgg      480

agaaacagtg atggttaatg cagcagctgg agctgtgggc tcagtcgtgg ggcagattgc      540

aaagctcaag ggctgcaaag ttgttggagc agtagggtct gatgaaaagg ttgcctacct      600

tcaaaagctt ggatttgatg tcgtctttaa ctacaagacg gtagagtctt tggaagaaac      660

cttgaagaaa gcgtctcctg atggttatga ttgttatttt gataatgtag gtggagagtt      720

ttcaaacact gttatcggcc agatgaagaa atttggaagg attgccatat gtggagccat      780

ctctacatat aacagaaccg gcccacttcc cccaggccca cccccagaga ttgttatcta      840

tcaggagctt cgcatggaag cttttgtcgt ctaccgctgg caaggagatg cccgccaaaa      900

gcagtcccag ccgccttccc caggcagtgg aaccttcggg ctcctgagct tcaggatggt      960

tcgtactaag acatggaccc tgaagaagca ctttgttggc tatcctacta atagtgactt     1020

tgagttgaag acagctgagc tcccaccctt aaaaaatgga gaggtcctgc ttgaagcttt     1080

gttcctcacc gtggatccct acatgagagt ggcagccaaa agattgaagg aaggtgatac     1140

aatgatgggg cagcaagtgg ccaaagttgt ggaaagtaaa aatgtagccc taccaaaagg     1200

aactattgta ctggcttctc caggctggac aacgcactcc atttctgatg ggaaagatct     1260

ggaaaagctg ctgacagagt ggccagacac aataccactg tctttggctc tggggacagt     1320

tggcatgcca ggcctgactg cctactttgg cctacttgaa atctgtggtg tgaagggtgg     1380

agaaacagtg atggttaatg cagcagctgg agctgtgggc tcagtcgtgg ggcagattgc     1440

aaagctcaag ggctgcaaag ttgttggagc agtagggtct gatgaaaagg ttgcctacct     1500

tcaaaagctt ggatttgatg tcgtctttaa ctacaagacg gtagagtctt tggaagaaac     1560

cttgaagaaa gcgtctcctg atggttatga ttgttatttt gataatgtag gtggagagtt     1620

ttcaaacact gttatcggcc agatgaagaa atttggaagg attgccatat gtggagccat     1680

ctctacatat aacagaaccg gcccacttcc cccaggccca cccccagaga ttgttatcta     1740

tcaggagctt cgcatggaag cttttgtcgt ctaccgctgg caaggagatg cccgccaaaa     1800

agctctgaag gacttgctga aatgggtctt agagggtaaa atccagtaca aggaatatat     1860

cattgaagga tttgaaaaca tgccagctgc atttatggga atgctgaaag gagataattt     1920

ggggaagaca atagtgaaag catgaaaaag aggacacatg gaatctggag gccatttaga     1980

tgattagtta atttgttttt caccatttag caaaaatgta tactacctta aatgtcttaa     2040

gaaatagtac tcataatgag tttgagctac ttaataaaat acatttaagt ggtatgtaat     2100

tagtgatgga ggatggaagt ttcaaagtca acaacaacca gtcacctcac tgttcactac     2160

agcttcttct gagttgtggt agaaaataat ggctttgaag tgtgaaaatt ttccaaacac     2220

tgtatgtttt cattcataag tgggagctga acaatgagaa cacatggaca tagggagggg     2280

aacaacacac gctggggcct gtggaagccg gggtgaggga gggagagcat caggataaat     2340

agctaatgcc ttcgggggct aatacctagg tgatgggttg acaggtgaag caaaccatca     2400

tggcacacgt ttacctatgt aacaaacctg cacattccac acaattatcc cggaactgaa     2460

aataaaataa aattaaatta aaaaaaaaag ttagccggg                            2499


<210>  3
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ala Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys Val Val Glu Ser Lys Asn Val Ala Leu Pro 
65                  70                  75                  80  


Lys Gly Thr Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile 
                85                  90                  95      


Ser Asp Gly Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr 
            100                 105                 110         


Ile Pro Leu Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr 
        115                 120                 125             


Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val Lys Gly Gly Glu Thr 
    130                 135                 140                 


Val Met Val Asn Ala Ala Ala Gly Ala Val Gly Ser Val Val Gly Gln 
145                 150                 155                 160 


Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly Ala Val Gly Ser Asp 
                165                 170                 175     


Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe Asp Val Val Phe Asn 
            180                 185                 190         


Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu Lys Lys Ala Ser Pro 
        195                 200                 205             


Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly Gly Glu Phe Ser Asn 
    210                 215                 220                 


Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg Ile Ala Ile Cys Gly 
225                 230                 235                 240 


Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu Pro Pro Gly Pro Pro 
                245                 250                 255     


Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met Glu Ala Phe Val Val 
            260                 265                 270         


Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala Leu Lys Asp Leu Leu 
        275                 280                 285             


Lys Trp Val Leu Glu Ile Lys Arg Glu Asn Glu Glu Asp 
    290                 295                 300     


<210>  4
<211>  1012
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding sequence

<400>  4
gcagtcccag ccgccttccc caggcagtgg aaccttcggg ctcctgagct tcaggatggt       60

tcgtactaag acatggaccc tgaagaagca ctttgttggc tatcctacta atagtgactt      120

tgagttgaag acagctgagc tcccaccctt aaaaaatgga gaggtcctgc ttgaagcttt      180

gttcctcacc gtggatccct acatgagagt ggcagccaaa agattgaagg aaggtgatac      240

aatgatgggg cagcaagtgg ccaaagttgt ggaaagtaaa aatgtagccc taccaaaagg      300

aactattgta ctggcttctc caggctggac aacgcactcc atttctgatg ggaaagatct      360

ggaaaagctg ctgacagagt ggccagacac aataccactg tctttggctc tggggacagt      420

tggcatgcca ggcctgactg cctactttgg cctacttgaa atctgtggtg tgaagggtgg      480

agaaacagtg atggttaatg cagcagctgg agctgtgggc tcagtcgtgg ggcagattgc      540

aaagctcaag ggctgcaaag ttgttggagc agtagggtct gatgaaaagg ttgcctacct      600

tcaaaagctt ggatttgatg tcgtctttaa ctacaagacg gtagagtctt tggaagaaac      660

cttgaagaaa gcgtctcctg atggttatga ttgttatttt gataatgtag gtggagagtt      720

ttcaaacact gttatcggcc agatgaagaa atttggaagg attgccatat gtggagccat      780

ctctacatat aacagaaccg gcccacttcc cccaggccca cccccagaga ttgttatcta      840

tcaggagctt cgcatggaag cttttgtcgt ctaccgctgg caaggagatg cccgccaaaa      900

agctctgaag gacttgctga aatgggtctt agagatcaaa agagaaaatg aagaagattg      960

aagcttcaaa gcagaaaaat gaagggaata tgtatcattc accattacct ta             1012


