                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsyvlania
 
<120>  COMPOSITIONS USEFUL FOR TREATING FRIEDRICH'S ATAXIA

<130>  UPN-21-9628.PCT

<150>  US 63/136,059
<151>  2021-01-11

<150>  US 63/232,927
<151>  2021-08-13

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  630
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(630)

<400>  1
atg tgg act ctc ggg cgc cgc gca gta gcc ggc ctc ctg gcg tca ccc         48
Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro           
1               5                   10                  15                

agc cca gcc cag gcc cag acc ctc acc cgg gtc ccg cgg ccg gca gag         96
Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu           
            20                  25                  30                    

ttg gcc cca ctc tgc ggc cgc cgt ggc ctg cgc acc gac atc gat gcg        144
Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala           
        35                  40                  45                        

acc tgc acg ccc cgc cgc gca agt tcg aac caa cgt ggc ctc aac cag        192
Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln           
    50                  55                  60                            

att tgg aat gtc aaa aag cag agt gtc tat ttg atg aat ttg agg aaa        240
Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys           
65                  70                  75                  80            

tct gga act ttg ggc cac cca ggc tct cta gat gag acc acc tat gaa        288
Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu           
                85                  90                  95                

aga cta gca gag gaa acg ctg gac tct tta gca gag ttt ttt gaa gac        336
Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp           
            100                 105                 110                   

ctt gca gac aag cca tac acg ttt gag gac tat gat gtc tcc ttt ggg        384
Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly           
        115                 120                 125                       

agt ggt gtc tta act gtc aaa ctg ggt gga gat cta gga acc tat gtg        432
Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val           
    130                 135                 140                           

atc aac aag cag acg cca aac aag caa atc tgg cta tct tct cca tcc        480
Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser           
145                 150                 155                 160           

agt gga cct aag cgt tat gac tgg act ggg aaa aac tgg gtg tac tcc        528
Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser           
                165                 170                 175               

cac gac ggc gtg tcc ctc cat gag ctg ctg gcc gca gag ctc act aaa        576
His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys           
            180                 185                 190                   

gcc tta aaa acc aaa ctg gac ttg tct tcc ttg gcc tat tcc gga aaa        624
Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys           
        195                 200                 205                       

gat gct                                                                630
Asp Ala                                                                   
    210                                                                   


<210>  2
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  3
<211>  630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered hFXN coding sequence

<400>  3
atgtggacac ttggccgcag agctgttgct ggcctgcttg cttctccatc tcccgctcaa       60

gcccagacac tgaccagagt gcctagacct gctgaactgg cccctctgtg tggcagaaga      120

ggcctgagaa ccgacatcga cgccacatgc acacctagaa gggccagcag caatcagcgg      180

ggcctgaatc agatctggaa cgtgaagaaa cagagcgtgt acctgatgaa cctgagaaag      240

agcggcaccc tgggacaccc tggaagcctg gacgagacaa cctacgagag actggccgag      300

gaaaccctgg attccctggc cgagttcttc gaggacctgg ccgataagcc ctacaccttc      360

gaggattacg acgtgtcctt tggcagcggc gtgctgacag tgaaactcgg cggagatctg      420

ggcacctacg tgatcaacaa gcagacccct aacaaacaga tctggctgag cagccctagc      480

agcggcccca agagatacga ttggaccggc aagaactggg tgtacagcca cgacggcgtg      540

tccctgcacg aactgctggc tgccgaactg acaaaggccc tgaaaacaaa gctggacctg      600

tccagcctgg cctactctgg caaggatgcc                                       630


<210>  4
<211>  2211
<212>  DNA
<213>  adeno-associated virus 68


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  4
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc agt         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gaa ggc att cgc gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro           
            20                  25                  30                    

aag gca aat caa caa cat caa gac aac gct cgg ggt ctt gtg ctt ccg        144
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggt tac aaa tac ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg        192
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gaa gca gac gcg gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aag gcc gga gac aac ccg tac ctc aag tac aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttc cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro           
        115                 120                 125                       

ctt ggt ctg gtt gag gaa gcg gct aag acg gct cct gga aag aag agg        432
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

cct gta gag cag tct cct cag gaa ccg gac tcc tcc gtg ggt att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly           
145                 150                 155                 160           

aaa tcg ggt gca cag ccc gct aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac aca gag tca gtc ccc gac cct caa cca atc gga gaa cct ccc        576
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro           
            180                 185                 190                   

gca gcc ccc tca ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc        624
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca gtg gca gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc        672
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser           
    210                 215                 220                           

tcg gga aat tgg cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aat cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc aac agc aca tct gga gga tct tca aat gac aac        816
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn           
            260                 265                 270                   

gcc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac aga        864
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg           
        275                 280                 285                       

ttc cac tgc cac ttc tca cca cgt gac tgg caa aga ctc atc aac aac        912
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn           
    290                 295                 300                           

aac tgg gga ttc cgg cct aag cga ctc aac ttc aag ctc ttc aac att        960
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile           
305                 310                 315                 320           

cag gtc aaa gag gtt acg gac aac aat gga gtc aag acc atc gct aat       1008
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn           
                325                 330                 335               

aac ctt acc agc acg gtc cag gtc ttc acg gac tca gac tat cag ctc       1056
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu           
            340                 345                 350                   

ccg tac gtg ctc ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca       1104
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro           
        355                 360                 365                       

gcg gac gtt ttc atg att cct cag tac ggg tat cta acg ctt aat gat       1152
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp           
    370                 375                 380                           

gga agc caa gcc gtg ggt cgt tcg tcc ttt tac tgc ctg gaa tat ttc       1200
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe           
385                 390                 395                 400           

ccg tcg caa atg cta aga acg ggt aac aac ttc cag ttc agc tac gag       1248
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu           
                405                 410                 415               

ttt gag aac gta cct ttc cat agc agc tat gct cac agc caa agc ctg       1296
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu           
            420                 425                 430                   

gac cga ctc atg aat cca ctc atc gac caa tac ttg tac tat ctc tca       1344
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser           
        435                 440                 445                       

aag act att aac ggt tct gga cag aat caa caa acg cta aaa ttc agt       1392
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser           
    450                 455                 460                           

gtg gcc gga ccc agc aac atg gct gtc cag gga aga aac tac ata cct       1440
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro           
465                 470                 475                 480           

gga ccc agc tac cga caa caa cgt gtc tca acc act gtg act caa aac       1488
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn           
                485                 490                 495               

aac aac agc gaa ttt gct tgg cct gga gct tct tct tgg gct ctc aat       1536
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn           
            500                 505                 510                   

gga cgt aat agc ttg atg aat cct gga cct gct atg gcc agc cac aaa       1584
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys           
        515                 520                 525                       

gaa gga gag gac cgt ttc ttt cct ttg tct gga tct tta att ttt ggc       1632
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly           
    530                 535                 540                           

aaa caa gga act gga aga gac aac gtg gat gcg gac aaa gtc atg ata       1680
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile           
545                 550                 555                 560           

acc aac gaa gaa gaa att aaa act acc aac cca gta gca acg gag tcc       1728
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser           
                565                 570                 575               

tat gga caa gtg gcc aca aac cac cag agt gcc caa gca cag gcg cag       1776
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln           
            580                 585                 590                   

acc ggc tgg gtt caa aac caa gga ata ctt ccg ggt atg gtt tgg cag       1824
Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gat gtg tac ctg caa gga ccc att tgg gcc aaa att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gac ggc aac ttt cac cct tct ccg ctg atg gga ggg ttt gga atg       1920
Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac aca cct gta cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

gat cct cca acg gct ttc aac aag gac aag ctg aac tct ttc atc acc       2016
Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr           
            660                 665                 670                   

cag tat tct act ggc caa gtc agc gtg gag att gag tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aag gaa aac agc aag cgc tgg aac ccg gag atc cag tac act tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat tac aag tct aat aat gtt gaa ttt gct gtt aat act gaa ggt gtt       2160
Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val           
705                 710                 715                 720           

tat tct gaa ccc cgc ccc att ggc acc aga tac ctg act cgt aat ctg       2208
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu           
                725                 730                 735               

taa                                                                   2211


<210>  5
<211>  736
<212>  PRT
<213>  adeno-associated virus 68

<400>  5

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  6
<211>  2208
<212>  DNA
<213>  adeno-associated virus 9


<220>
<221>  CDS
<222>  (1)..(2208)
<223>  AAV9 VP1 Capsid

<400>  6
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctt agt         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gaa gga att cgc gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro           
            20                  25                  30                    

aag gca aat caa caa cat caa gac aac gct cga ggt ctt gtg ctt ccg        144
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggt tac aaa tac ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg        192
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gca gca gac gcg gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aag gcc gga gac aac ccg tac ctc aag tac aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttc cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro           
        115                 120                 125                       

ctt ggt ctg gtt gag gaa gcg gct aag acg gct cct gga aag aag agg        432
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

cct gta gag cag tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly           
145                 150                 155                 160           

aaa tcg ggt gca cag ccc gct aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac aca gag tca gtc cca gac cct caa cca atc gga gaa cct ccc        576
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro           
            180                 185                 190                   

gca gcc ccc tca ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc        624
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca gtg gca gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc        672
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser           
    210                 215                 220                           

tcg gga aat tgg cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aat cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc aac agc aca tct gga gga tct tca aat gac aac        816
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn           
            260                 265                 270                   

gcc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac aga        864
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg           
        275                 280                 285                       

ttc cac tgc cac ttc tca cca cgt gac tgg cag cga ctc atc aac aac        912
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn           
    290                 295                 300                           

aac tgg gga ttc cgg cct aag cga ctc aac ttc aag ctc ttc aac att        960
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile           
305                 310                 315                 320           

cag gtc aaa gag gtt acg gac aac aat gga gtc aag acc atc gcc aat       1008
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn           
                325                 330                 335               

aac ctt acc agc acg gtc cag gtc ttc acg gac tca gac tat cag ctc       1056
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu           
            340                 345                 350                   

ccg tac gtg ctc ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca       1104
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro           
        355                 360                 365                       

gcg gac gtt ttc atg att cct cag tac ggg tat ctg acg ctt aat gat       1152
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp           
    370                 375                 380                           

gga agc cag gcc gtg ggt cgt tcg tcc ttt tac tgc ctg gaa tat ttc       1200
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe           
385                 390                 395                 400           

ccg tcg caa atg cta aga acg ggt aac aac ttc cag ttc agc tac gag       1248
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu           
                405                 410                 415               

ttt gag aac gta cct ttc cat agc agc tac gct cac agc caa agc ctg       1296
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu           
            420                 425                 430                   

gac cga cta atg aat cca ctc atc gac caa tac ttg tac tat ctc tca       1344
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser           
        435                 440                 445                       

aag act att aac ggt tct gga cag aat caa caa acg cta aaa ttc agt       1392
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser           
    450                 455                 460                           

gtg gcc gga ccc agc aac atg gct gtc cag gga aga aac tac ata cct       1440
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro           
465                 470                 475                 480           

gga ccc agc tac cga caa caa cgt gtc tca acc act gtg act caa aac       1488
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn           
                485                 490                 495               

aac aac agc gaa ttt gct tgg cct gga gct tct tct tgg gct ctc aat       1536
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn           
            500                 505                 510                   

gga cgt aat agc ttg atg aat cct gga cct gct atg gcc agc cac aaa       1584
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys           
        515                 520                 525                       

gaa gga gag gac cgt ttc ttt cct ttg tct gga tct tta att ttt ggc       1632
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly           
    530                 535                 540                           

aaa caa gga act gga aga gac aac gtg gat gcg gac aaa gtc atg ata       1680
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile           
545                 550                 555                 560           

acc aac gaa gaa gaa att aaa act act aac ccg gta gca acg gag tcc       1728
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser           
                565                 570                 575               

tat gga caa gtg gcc aca aac cac cag agt gcc caa gca cag gcg cag       1776
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln           
            580                 585                 590                   

acc ggc tgg gtt caa aac caa gga ata ctt ccg ggt atg gtt tgg cag       1824
Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gat gtg tac ctg caa gga ccc att tgg gcc aaa att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gac ggc aac ttt cac cct tct ccg ctg atg gga ggg ttt gga atg       1920
Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac aca cct gta cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

gat cct cca acg gcc ttc aac aag gac aag ctg aac tct ttc atc acc       2016
Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr           
            660                 665                 670                   

cag tat tct act ggc caa gtc agc gtg gag atc gag tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aag gaa aac agc aag cgc tgg aac ccg gag atc cag tac act tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat tac aag tct aat aat gtt gaa ttt gct gtt aat act gaa ggt gta       2160
Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val           
705                 710                 715                 720           

tat agt gaa ccc cgc ccc att ggc acc aga tac ctg act cgt aat ctg       2208
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu           
                725                 730                 735               


<210>  7
<211>  736
<212>  PRT
<213>  adeno-associated virus 9

<400>  7

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  8
<211>  2955
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB7.CI.hFXNco


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  promoter
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  TATA_signal
<222>  (836)..(838)

<220>
<221>  Intron
<222>  (958)..(1930)

<220>
<221>  misc_feature
<222>  (1942)..(2572)
<223>  human FXN

<220>
<221>  polyA_signal
<222>  (2611)..(2737)
<223>  Rabbit globin polyA

<220>
<221>  repeat_unit
<222>  (2826)..(2955)
<223>  3' ITR

<400>  8
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattcgccac catgtggaca cttggccgca gagctgttgc tggcctgctt     1980

gcttctccat ctcccgctca agcccagaca ctgaccagag tgcctagacc tgctgaactg     2040

gcccctctgt gtggcagaag aggcctgaga accgacatcg acgccacatg cacacctaga     2100

agggccagca gcaatcagcg gggcctgaat cagatctgga acgtgaagaa acagagcgtg     2160

tacctgatga acctgagaaa gagcggcacc ctgggacacc ctggaagcct ggacgagaca     2220

acctacgaga gactggccga ggaaaccctg gattccctgg ccgagttctt cgaggacctg     2280

gccgataagc cctacacctt cgaggattac gacgtgtcct ttggcagcgg cgtgctgaca     2340

gtgaaactcg gcggagatct gggcacctac gtgatcaaca agcagacccc taacaaacag     2400

atctggctga gcagccctag cagcggcccc aagagatacg attggaccgg caagaactgg     2460

gtgtacagcc acgacggcgt gtccctgcac gaactgctgg ctgccgaact gacaaaggcc     2520

ctgaaaacaa agctggacct gtccagcctg gcctactctg gcaaggatgc ctgatgactc     2580

gaggacgggg tgaactacgc ctgaggatcc gatctttttc cctctgccaa aaattatggg     2640

gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt tattttcatt     2700

gcaatagtgt gttggaattt tttgtgtctc tcactcggaa gcaattcgtt gatctgaatt     2760

tcgaccaccc ataataccca ttaccctggt agataagtag catggcgggt taatcattaa     2820

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     2880

tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag     2940

cgagcgagcg cgcag                                                      2955


<210>  9
<211>  2211
<212>  DNA
<213>  adeno-associated virus rh.91


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  9
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gcg ctg aaa cct gga gcc ccg aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ttt ggt ctg gtt gag gaa gca gct aag acg gct cct gga aag aaa cgt        432
Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cag tcg ccc caa gaa cca gac tcc tcc tcg ggc att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly           
145                 150                 155                 160           

aaa tca ggc cag cag ccc gcc aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac tca gag tca gtc ccc gac cct caa cct ctc gga gaa cct cca        576
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro           
            180                 185                 190                   

gaa acc ccc gct gct gtg gga cct act aca atg gct tca ggc ggt ggc        624
Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc        672
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala           
    210                 215                 220                           

tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctt cct acc tac aac aac cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc agc gct tca acg ggg gcc agt aac gac aac cac        816
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tat ttt gat ttc aac aga ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tca cca cgt gac tgg cag cga ctc att aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg gga ttc cgg ccc aag aga ctc aac ttc aag ctc ttc aac atc cag        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gag gtc acg acg aat gat ggc gtc aca acc atc gct aat aac       1008
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt caa gtg ttc tcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tac gtc ctc ggt tct gcg cac cag ggc tgc ctc cct ccg ttc ccg gcg       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gta ttc atg att cct cag tac ggc tac cta acg ctc aac aat ggc       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agc cag gcc gta gga cgt tca tcc ttt tat tgc ctg gaa tat ttc cca       1200
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tct caa atg ctg aga acg ggc aac aac ttt acc ttc agc tac acc ttt       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gaa gat gtg cct ttc cac agc agt tac gcg cac agc cag agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

agg cta atg aat cct cta atc gac cag tac ctg tat tac cta aac aga       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg           
        435                 440                 445                       

act cag aat caa tcc gga agt gca caa aac aag gac ttg ctg ttt agc       1392
Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser           
    450                 455                 460                           

cgg ggg tct cca gct ggc atg tct gtt cag ccc aaa aac tgg cta ccc       1440
Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro           
465                 470                 475                 480           

ggg ccc tgt tac cga cag cag cgt gtt tct aaa aca aaa aca gac aac       1488
Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn           
                485                 490                 495               

aac aac agc aac ttt acc tgg act ggt gcc tcc aaa tac aat ctg aac       1536
Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn           
            500                 505                 510                   

gga cgt gaa tcc atc att aac cct ggc acc gct atg gca tcc cac aag       1584
Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys           
        515                 520                 525                       

gac gac gaa gac aaa ttt ttt ccc atg agc ggt gtt atg att ttt ggc       1632
Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly           
    530                 535                 540                           

aaa gaa aat gca gga gca tca aac act gca tta gac aat gtt atg att       1680
Lys Glu Asn Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile           
545                 550                 555                 560           

aca gat gaa gag gaa att aaa gct acc aac ccc gtg gcc acc gag aga       1728
Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg           
                565                 570                 575               

ttt gga act gtg gca gtc aat ctc caa agc agc aat aca gac cct gca       1776
Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Asn Thr Asp Pro Ala           
            580                 585                 590                   

aca gga gac gtg cat gtc atg ggg gct tta cct ggc atg gtg tgg caa       1824
Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gac gtg tac ctg cag ggt ccc att tgg gcc aag att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gat gga cac ttt cac ccg tct cct ctt atg ggc ggc ttt gga ctt       1920
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac acg cct gtt cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

aat cct ccg gca gag ttt tcg gct aca aag ttt gct tca ttc atc acc       2016
Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr           
            660                 665                 670                   

cag tac tcc aca gga caa gtg agc gtg gaa att gaa tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aaa gaa aac agt aag cgc tgg aat cct gaa gtg cag tac acc tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tac gcg aaa tct gcc aac gtt gat ttc act gtg gac aac aat gga ctt       2160
Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu           
705                 710                 715                 720           

tat act gag cct cgc ccc att ggc acc cgt tac ctt acc cgt ccc ctt       2208
Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu           
                725                 730                 735               

taa                                                                   2211


<210>  10
<211>  736
<212>  PRT
<213>  adeno-associated virus rh.91

<400>  10

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Asn Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Asn Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  11
<211>  2211
<212>  DNA
<213>  adeno-associated virus rh.91


<220>
<221>  misc_feature
<222>  (1)..(2211)
<223>  AAVrh.91

<400>  11
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagcccct aaacccaaag cgaaccaaca aaagcaggac      120

gacggccggg gtcttgtgct tccgggttac aaatacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacgc ggcggacgcg gcagccctcg aacacgacaa agcttacgac      240

cagcagctca aggccggtga caacccgtac ctccggtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga gggttcttga gccttttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcatcatc tggtattggc      480

aaatcgggcc agcagcctgc caaaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtccccg accctcaacc tctcggagaa cctccagaaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggcccttcct acctacaaca accacctcta caagcaaatc      780

tccagcgctt caacgggggc cagtaacgac aaccactact ttggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttctcac cacgtgactg gcagcgactc      900

attaacaaca actggggatt ccggcccaag agactcaact tcaagctctt caacatccag      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtgt tctcggactc ggagtaccag ctgccgtacg tcctcggttc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgta ttcatgattc ctcagtatgg atacctcacc     1140

ctgaacaacg gaagtcaagc ggtgggacgc tcatcctttt actgcctgga gtacttccct     1200

tcgcagatgc taaggactgg aaataacttc accttcagct ataccttcga ggatgtacct     1260

tttcacagca gctacgctca cagccagagt ttggatcgct tgatgaatcc tcttattgat     1320

cagtatctgt actacctgaa cagaacgcaa aatcaatctg gaagtgcaca aaacaaggac     1380

ctgcttttta gccgggggtc tcctgctggc atgtctgttc agcccaaaaa ttggctacct     1440

gggccctgct accggcaaca gagagtttca aagactaaaa cagacaacaa caacagtaac     1500

tttacctgga caggtgccag caaatataat ctcaatggcc gcgaatcgat cattaatcca     1560

ggaaccgcta tggccagtca caaggacgat gaagacaaat ttttccctat gagcggcgtt     1620

atgatatttg gcaaagaaaa tgcaggagca agtaacactg cattagataa tgtaatgatt     1680

acggatgaag aagagattaa agctaccaat cctgtggcaa cagagagatt tggaactgtg     1740

gcagtcaact tgcagagctc aaatacagac cccgcaactg gagacgtcca tgtcatgggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat cctcatcaaa aatactccgg taccggcaaa tcctccggca     1980

gagttcagcg ctacaaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agaggtgcag     2100

tacacttcca actacgcgaa gtctgccaat gtggacttta ctgtagacaa caatggtctt     2160

tatactgaac ctcgccctat tggaacccgg tatctcacac gacccttgta a              2211


<210>  12
<211>  2954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vecotr genome AAV.CB7.CI.hFXNco.RBG


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  repeat_region
<222>  (198)..(579)
<223>  CMV IE enhancer

<220>
<221>  promoter
<222>  (585)..(862)
<223>  Chicken beta-actin promoter

<220>
<221>  TATA_signal
<222>  (836)..(862)
<223>  TATA

<220>
<221>  Intron
<222>  (957)..(1929)
<223>  chicken beta-actin intron

<220>
<221>  Intron
<222>  (957)..(1929)
<223>  chimeric intron

<220>
<221>  misc_feature
<222>  (1941)..(2570)
<223>  hFXNco

<220>
<221>  polyA_signal
<222>  (2610)..(2736)
<223>  Rabbit globin poly A

<220>
<221>  repeat_region
<222>  (2825)..(2954)
<223>  3'ITR

<400>  12
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgcgctg ccttcgcccc gtgccccgct      900

ccgccgccgc ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga      960

gcgggcggga cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg     1020

tttcttttct gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg     1080

ggagcggctc ggggggtgcg tgcgtgtgtg tgtgcgtggg gagcgccgcg tgcggctccg     1140

cgctgcccgg cggctgtgag cgctgcgggc gcggcgcggg gctttgtgcg ctccgcagtg     1200

tgcgcgaggg gagcgcggcc gggggcggtg ccccgcggtg cggggggggc tgcgagggga     1260

acaaaggctg cgtgcggggt gtgtgcgtgg gggggtgagc agggggtgtg ggcgcgtcgg     1320

tcgggctgca accccccctg cacccccctc cccgagttgc tgagcacggc ccggcttcgg     1380

gtgcggggct ccgtacgggg cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc     1440

aggtgggggt gccgggcggg gcggggccgc ctcgggccgg ggagggctcg ggggaggggc     1500

gcggcggccc ccggagcgcc ggcggctgtc gaggcgcggc gagccgcagc cattgccttt     1560

tatggtaatc gtgcgagagg gcgcagggac ttcctttgtc ccaaatctgt gcggagccga     1620

aatctgggag gcgccgccgc accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg     1680

gcaggaagga aatgggcggg gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc     1740

ctctccagcc tcggggctgt ccgcgggggg acggctgcct tcggggggga cggggcaggg     1800

cggggttcgg cttctggcgt gtgaccggcg gctctagagc ctctgctaac catgttcatg     1860

ccttcttctt tttcctacag ctcctgggca acgtgctggt tattgtgctg tctcatcatt     1920

ttggcaaaga attcgccacc atgtggacac ttggccgcag agctgttgct ggcctgcttg     1980

cttctccatc tcccgctcaa gcccagacac tgaccagagt gcctagacct gctgaactgg     2040

cccctctgtg tggcagaaga ggcctgagaa ccgacatcga cgccacatgc acacctagaa     2100

gggccagcag caatcagcgg ggcctgaatc agatctggaa cgtgaagaaa cagagcgtgt     2160

acctgatgaa cctgagaaag agcggcaccc tgggacaccc tggaagcctg gacgagacaa     2220

cctacgagag actggccgag gaaaccctgg attccctggc cgagttcttc gaggacctgg     2280

ccgataagcc ctacaccttc gaggattacg acgtgtcctt tggcagcggc gtgctgacag     2340

tgaaactcgg cggagatctg ggcacctacg tgatcaacaa gcagacccct aacaaacaga     2400

tctggctgag cagccctagc agcggcccca agagatacga ttggaccggc aagaactggg     2460

tgtacagcca cgacggcgtg tccctgcacg aactgctggc tgccgaactg acaaaggccc     2520

tgaaaacaaa gctggacctg tccagcctgg cctactctgg caaggatgcc tgatgactcg     2580

aggacggggt gaactacgcc tgaggatccg atctttttcc ctctgccaaa aattatgggg     2640

acatcatgaa gccccttgag catctgactt ctggctaata aaggaaattt attttcattg     2700

caatagtgtg ttggaatttt ttgtgtctct cactcggaag caattcgttg atctgaattt     2760

cgaccaccca taatacccat taccctggta gataagtagc atggcgggtt aatcattaac     2820

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     2880

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     2940

gagcgagcgc gcag                                                       2954


<210>  13
<211>  2540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette (1) CB7.CI.hFXNco.RBG


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE enhancer

<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (385)..(666)
<223>  CB promoter

<220>
<221>  Intron
<222>  (761)..(1733)
<223>  chimeric intron

<220>
<221>  misc_feature
<222>  (1745)..(2374)
<223>  hFXN coding sequence

<220>
<221>  polyA_signal
<222>  (2414)..(2540)
<223>  rabbit beta globin polyA

<400>  13
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg actatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcggggag tcgctgcgac gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg      720

ccgcccgccc cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc      780

ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct      840

gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg      900

tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg      960

tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc     1020

ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg     1080

gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc     1140

cctgcacccc cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac     1200

ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg     1260

cggggcgggg ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag     1320

cgccggcggc tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga     1380

gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg     1440

ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg     1500

cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg     1560

ctgtccgcgg ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg     1620

gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct     1680

acagctcctg ggcaacgtgc tggttattgt gctgtctcat cattttggca aagaattcgc     1740

caccatgtgg acacttggcc gcagagctgt tgctggcctg cttgcttctc catctcccgc     1800

tcaagcccag acactgacca gagtgcctag acctgctgaa ctggcccctc tgtgtggcag     1860

aagaggcctg agaaccgaca tcgacgccac atgcacacct agaagggcca gcagcaatca     1920

gcggggcctg aatcagatct ggaacgtgaa gaaacagagc gtgtacctga tgaacctgag     1980

aaagagcggc accctgggac accctggaag cctggacgag acaacctacg agagactggc     2040

cgaggaaacc ctggattccc tggccgagtt cttcgaggac ctggccgata agccctacac     2100

cttcgaggat tacgacgtgt cctttggcag cggcgtgctg acagtgaaac tcggcggaga     2160

tctgggcacc tacgtgatca acaagcagac ccctaacaaa cagatctggc tgagcagccc     2220

tagcagcggc cccaagagat acgattggac cggcaagaac tgggtgtaca gccacgacgg     2280

cgtgtccctg cacgaactgc tggctgccga actgacaaag gccctgaaaa caaagctgga     2340

cctgtccagc ctggcctact ctggcaagga tgcctgatga ctcgaggacg gggtgaacta     2400

cgcctgagga tccgatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct     2460

tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     2520

ttttttgtgt ctctcactcg                                                 2540


<210>  14
<211>  2539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression cassette (2) CB7.CI.hFXNco.RBG


<220>
<221>  enhancer
<222>  (1)..(382)
<223>  CMV IE enhancer

<220>
<221>  misc_feature
<222>  (1)..(665)
<223>  CB7 hybrid promoter

<220>
<221>  promoter
<222>  (388)..(665)
<223>  chicken beta actin promoter

<220>
<221>  Intron
<222>  (760)..(1732)
<223>  chimeric intron

<220>
<221>  misc_feature
<222>  (1744)..(2373)
<223>  hFXN coding sequence

<220>
<221>  polyA_signal
<222>  (2413)..(2539)
<223>  rabbit beta globin polyA

<400>  14
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcggggag tcgctgcgcg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc      720

cgcccgcccc ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct      780

tctcctccgg gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg      840

cgtgaaagcc ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt      900

gcgtgcgtgt gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt      960

gagcgctgcg ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg     1020

gccgggggcg gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg     1080

ggtgtgtgcg tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc     1140

ctgcaccccc ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg     1200

gggcgtggcg cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc     1260

ggggcggggc cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc     1320

gccggcggct gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag     1380

agggcgcagg gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc     1440

cgcaccccct ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc     1500

ggggagggcc ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc     1560

tgtccgcggg gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg     1620

cgtgtgaccg gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta     1680

cagctcctgg gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattcgcc     1740

accatgtgga cacttggccg cagagctgtt gctggcctgc ttgcttctcc atctcccgct     1800

caagcccaga cactgaccag agtgcctaga cctgctgaac tggcccctct gtgtggcaga     1860

agaggcctga gaaccgacat cgacgccaca tgcacaccta gaagggccag cagcaatcag     1920

cggggcctga atcagatctg gaacgtgaag aaacagagcg tgtacctgat gaacctgaga     1980

aagagcggca ccctgggaca ccctggaagc ctggacgaga caacctacga gagactggcc     2040

gaggaaaccc tggattccct ggccgagttc ttcgaggacc tggccgataa gccctacacc     2100

ttcgaggatt acgacgtgtc ctttggcagc ggcgtgctga cagtgaaact cggcggagat     2160

ctgggcacct acgtgatcaa caagcagacc cctaacaaac agatctggct gagcagccct     2220

agcagcggcc ccaagagata cgattggacc ggcaagaact gggtgtacag ccacgacggc     2280

gtgtccctgc acgaactgct ggctgccgaa ctgacaaagg ccctgaaaac aaagctggac     2340

ctgtccagcc tggcctactc tggcaaggat gcctgatgac tcgaggacgg ggtgaactac     2400

gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt     2460

gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat     2520

tttttgtgtc tctcactcg                                                  2539


<210>  15
<211>  599
<212>  PRT
<213>  adeno-associated virus hu68 VP2

<400>  15

Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln Ser Pro Gln Glu Pro 
1               5                   10                  15      


Asp Ser Ser Val Gly Ile Gly Lys Ser Gly Ala Gln Pro Ala Lys Lys 
            20                  25                  30          


Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu Ser Val Pro Asp Pro 
        35                  40                  45              


Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser Gly Val Gly Ser Leu 
    50                  55                  60                  


Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala Asp Asn Asn Glu Gly 
65                  70                  75                  80  


Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln 
                85                  90                  95      


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
            100                 105                 110         


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
        115                 120                 125             


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
    130                 135                 140                 


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
145                 150                 155                 160 


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
                165                 170                 175     


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
            180                 185                 190         


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
        195                 200                 205             


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
    210                 215                 220                 


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
225                 230                 235                 240 


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
                245                 250                 255     


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
            260                 265                 270         


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
        275                 280                 285             


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
    290                 295                 300                 


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn 
305                 310                 315                 320 


Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
                325                 330                 335     


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
            340                 345                 350         


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
        355                 360                 365             


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
    370                 375                 380                 


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
385                 390                 395                 400 


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
                405                 410                 415     


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
            420                 425                 430         


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
        435                 440                 445             


Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
    450                 455                 460                 


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
465                 470                 475                 480 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
                485                 490                 495     


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
            500                 505                 510         


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
        515                 520                 525             


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
    530                 535                 540                 


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
545                 550                 555                 560 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
                565                 570                 575     


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
            580                 585                 590         


Arg Tyr Leu Thr Arg Asn Leu 
        595                 


<210>  16
<211>  1800
<212>  DNA
<213>  adeno-associated virus hu68 VP2

<400>  16
acggctcctg gaaagaagag gcctgtagag cagtctcctc aggaaccgga ctcctccgtg       60

ggtattggca aatcgggtgc acagcccgct aaaaagagac tcaatttcgg tcagactggc      120

gacacagagt cagtccccga ccctcaacca atcggagaac ctcccgcagc cccctcaggt      180

gtgggatctc ttacaatggc ttcaggtggt ggcgcaccag tggcagacaa taacgaaggt      240

gccgatggag tgggtagttc ctcgggaaat tggcattgcg attcccaatg gctgggggac      300

agagtcatca ccaccagcac ccgaacctgg gccctgccca cctacaacaa tcacctctac      360

aagcaaatct ccaacagcac atctggagga tcttcaaatg acaacgccta cttcggctac      420

agcaccccct gggggtattt tgacttcaac agattccact gccacttctc accacgtgac      480

tggcaaagac tcatcaacaa caactgggga ttccggccta agcgactcaa cttcaagctc      540

ttcaacattc aggtcaaaga ggttacggac aacaatggag tcaagaccat cgctaataac      600

cttaccagca cggtccaggt cttcacggac tcagactatc agctcccgta cgtgctcggg      660

tcggctcacg agggctgcct cccgccgttc ccagcggacg ttttcatgat tcctcagtac      720

gggtatctaa cgcttaatga tggaagccaa gccgtgggtc gttcgtcctt ttactgcctg      780

gaatatttcc cgtcgcaaat gctaagaacg ggtaacaact tccagttcag ctacgagttt      840

gagaacgtac ctttccatag cagctatgct cacagccaaa gcctggaccg actcatgaat      900

ccactcatcg accaatactt gtactatctc tcaaagacta ttaacggttc tggacagaat      960

caacaaacgc taaaattcag tgtggccgga cccagcaaca tggctgtcca gggaagaaac     1020

tacatacctg gacccagcta ccgacaacaa cgtgtctcaa ccactgtgac tcaaaacaac     1080

aacagcgaat ttgcttggcc tggagcttct tcttgggctc tcaatggacg taatagcttg     1140

atgaatcctg gacctgctat ggccagccac aaagaaggag aggaccgttt ctttcctttg     1200

tctggatctt taatttttgg caaacaagga actggaagag acaacgtgga tgcggacaaa     1260

gtcatgataa ccaacgaaga agaaattaaa actaccaacc cagtagcaac ggagtcctat     1320

ggacaagtgg ccacaaacca ccagagtgcc caagcacagg cgcagaccgg ctgggttcaa     1380

aaccaaggaa tacttccggg tatggtttgg caggacagag atgtgtacct gcaaggaccc     1440

atttgggcca aaattcctca cacggacggc aactttcacc cttctccgct gatgggaggg     1500

tttggaatga agcacccgcc tcctcagatc ctcatcaaaa acacacctgt acctgcggat     1560

cctccaacgg ctttcaacaa ggacaagctg aactctttca tcacccagta ttctactggc     1620

caagtcagcg tggagattga gtgggagctg cagaaggaaa acagcaagcg ctggaacccg     1680

gagatccagt acacttccaa ctattacaag tctaataatg ttgaatttgc tgttaatact     1740

gaaggtgttt attctgaacc ccgccccatt ggcaccagat acctgactcg taatctgtaa     1800


<210>  17
<211>  534
<212>  PRT
<213>  adeno-associated virus hu68 VP3

<400>  17

Met Ala Ser Gly Gly Gly Ala Pro Val Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
            20                  25                  30          


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
    50                  55                  60                  


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
65                  70                  75                  80  


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
                85                  90                  95      


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
            100                 105                 110         


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
        115                 120                 125             


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
    130                 135                 140                 


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
145                 150                 155                 160 


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
                165                 170                 175     


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
            180                 185                 190         


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
        195                 200                 205             


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
    210                 215                 220                 


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
225                 230                 235                 240 


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
                245                 250                 255     


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
            260                 265                 270         


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
        275                 280                 285             


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
    290                 295                 300                 


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
305                 310                 315                 320 


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
                325                 330                 335     


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
            340                 345                 350         


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
        355                 360                 365             


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
    370                 375                 380                 


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
385                 390                 395                 400 


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
                405                 410                 415     


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
            420                 425                 430         


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
        435                 440                 445             


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
    450                 455                 460                 


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
465                 470                 475                 480 


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
                485                 490                 495     


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
            500                 505                 510         


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
        515                 520                 525             


Tyr Leu Thr Arg Asn Leu 
    530                 


<210>  18
<211>  1605
<212>  DNA
<213>  adeno-associated virus hu68 VP3

<400>  18
atggcttcag gtggtggcgc accagtggca gacaataacg aaggtgccga tggagtgggt       60

agttcctcgg gaaattggca ttgcgattcc caatggctgg gggacagagt catcaccacc      120

agcacccgaa cctgggccct gcccacctac aacaatcacc tctacaagca aatctccaac      180

agcacatctg gaggatcttc aaatgacaac gcctacttcg gctacagcac cccctggggg      240

tattttgact tcaacagatt ccactgccac ttctcaccac gtgactggca aagactcatc      300

aacaacaact ggggattccg gcctaagcga ctcaacttca agctcttcaa cattcaggtc      360

aaagaggtta cggacaacaa tggagtcaag accatcgcta ataaccttac cagcacggtc      420

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc      480

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctaacgctt      540

aatgatggaa gccaagccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg      600

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc      660

catagcagct atgctcacag ccaaagcctg gaccgactca tgaatccact catcgaccaa      720

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa      780

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc      840

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct      900

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct      960

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1020

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1080

gaagaagaaa ttaaaactac caacccagta gcaacggagt cctatggaca agtggccaca     1140

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1200

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatttg ggccaaaatt     1260

cctcacacgg acggcaactt tcacccttct ccgctgatgg gagggtttgg aatgaagcac     1320

ccgcctcctc agatcctcat caaaaacaca cctgtacctg cggatcctcc aacggctttc     1380

aacaaggaca agctgaactc tttcatcacc cagtattcta ctggccaagt cagcgtggag     1440

attgagtggg agctgcagaa ggaaaacagc aagcgctgga acccggagat ccagtacact     1500

tccaactatt acaagtctaa taatgttgaa tttgctgtta atactgaagg tgtttattct     1560

gaaccccgcc ccattggcac cagatacctg actcgtaatc tgtaa                     1605


<210>  19
<211>  599
<212>  PRT
<213>  adeno-associated virus rh91 VP2

<400>  19

Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln Ser Pro Gln Glu Pro 
1               5                   10                  15      


Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Gln Gln Pro Ala Lys Lys 
            20                  25                  30          


Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser Val Pro Asp Pro 
        35                  40                  45              


Gln Pro Leu Gly Glu Pro Pro Glu Thr Pro Ala Ala Val Gly Pro Thr 
    50                  55                  60                  


Thr Met Ala Ser Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly 
65                  70                  75                  80  


Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr 
                85                  90                  95      


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
            100                 105                 110         


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr 
        115                 120                 125             


Gly Ala Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
    130                 135                 140                 


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
145                 150                 155                 160 


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
                165                 170                 175     


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Thr Asn Asp Gly 
            180                 185                 190         


Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ser 
        195                 200                 205             


Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly 
    210                 215                 220                 


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
225                 230                 235                 240 


Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
                245                 250                 255     


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
            260                 265                 270         


Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr 
        275                 280                 285             


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
    290                 295                 300                 


Tyr Leu Tyr Tyr Leu Asn Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln 
305                 310                 315                 320 


Asn Lys Asp Leu Leu Phe Ser Arg Gly Ser Pro Ala Gly Met Ser Val 
                325                 330                 335     


Gln Pro Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val 
            340                 345                 350         


Ser Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly 
        355                 360                 365             


Ala Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly 
    370                 375                 380                 


Thr Ala Met Ala Ser His Lys Asp Asp Glu Asp Lys Phe Phe Pro Met 
385                 390                 395                 400 


Ser Gly Val Met Ile Phe Gly Lys Glu Asn Ala Gly Ala Ser Asn Thr 
                405                 410                 415     


Ala Leu Asp Asn Val Met Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr 
            420                 425                 430         


Asn Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Leu Gln 
        435                 440                 445             


Ser Ser Asn Thr Asp Pro Ala Thr Gly Asp Val His Val Met Gly Ala 
    450                 455                 460                 


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
465                 470                 475                 480 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro 
                485                 490                 495     


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
            500                 505                 510         


Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr 
        515                 520                 525             


Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
    530                 535                 540                 


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
545                 550                 555                 560 


Glu Val Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe 
                565                 570                 575     


Thr Val Asp Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr 
            580                 585                 590         


Arg Tyr Leu Thr Arg Pro Leu 
        595                 


<210>  20
<211>  1800
<212>  DNA
<213>  adeno-associated virus rh91 VP2

<400>  20
acggctcctg gaaagaaacg tccggtagag cagtcgcccc aagaaccaga ctcctcctcg       60

ggcattggca aatcaggcca gcagcccgcc aaaaagagac tcaatttcgg tcagactggc      120

gactcagagt cagtccccga ccctcaacct ctcggagaac ctccagaaac ccccgctgct      180

gtgggaccta ctacaatggc ttcaggcggt ggcgcaccaa tggcagacaa taacgaaggc      240

gccgacggag tgggtaatgc ctcaggaaat tggcattgcg attccacatg gctgggcgac      300

agagtcatca ccaccagcac ccgaacctgg gcccttccta cctacaacaa ccacctctac      360

aagcaaatct ccagcgcttc aacgggggcc agtaacgaca accactactt tggctacagc      420

accccctggg ggtattttga tttcaacaga ttccactgcc acttctcacc acgtgactgg      480

cagcgactca ttaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc      540

aacatccagg tcaaggaggt cacgacgaat gatggcgtca caaccatcgc taataacctt      600

accagcacgg ttcaagtgtt ctcggactcg gagtaccagc tgccgtacgt cctcggttct      660

gcgcaccagg gctgcctccc tccgttcccg gcggacgtat tcatgattcc tcagtacggc      720

tacctaacgc tcaacaatgg cagccaggcc gtaggacgtt catcctttta ttgcctggaa      780

tatttcccat ctcaaatgct gagaacgggc aacaacttta ccttcagcta cacctttgaa      840

gatgtgcctt tccacagcag ttacgcgcac agccagagcc tggacaggct aatgaatcct      900

ctaatcgacc agtacctgta ttacctaaac agaactcaga atcaatccgg aagtgcacaa      960

aacaaggact tgctgtttag ccgggggtct ccagctggca tgtctgttca gcccaaaaac     1020

tggctacccg ggccctgtta ccgacagcag cgtgtttcta aaacaaaaac agacaacaac     1080

aacagcaact ttacctggac tggtgcctcc aaatacaatc tgaacggacg tgaatccatc     1140

attaaccctg gcaccgctat ggcatcccac aaggacgacg aagacaaatt ttttcccatg     1200

agcggtgtta tgatttttgg caaagaaaat gcaggagcat caaacactgc attagacaat     1260

gttatgatta cagatgaaga ggaaattaaa gctaccaacc ccgtggccac cgagagattt     1320

ggaactgtgg cagtcaatct ccaaagcagc aatacagacc ctgcaacagg agacgtgcat     1380

gtcatggggg ctttacctgg catggtgtgg caagacagag acgtgtacct gcagggtccc     1440

atttgggcca agattcctca cacggatgga cactttcacc cgtctcctct tatgggcggc     1500

tttggactta agcacccgcc tcctcagatc ctcatcaaaa acacgcctgt tcctgcgaat     1560

cctccggcag agttttcggc tacaaagttt gcttcattca tcacccagta ctccacagga     1620

caagtgagcg tggaaattga atgggagctg cagaaagaaa acagtaagcg ctggaatcct     1680

gaagtgcagt acacctccaa ctacgcgaaa tctgccaacg ttgatttcac tgtggacaac     1740

aatggacttt atactgagcc tcgccccatt ggcacccgtt accttacccg tcccctttaa     1800


<210>  21
<211>  534
<212>  PRT
<213>  adeno-associated virus rh91 VP3

<400>  21

Met Ala Ser Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly 
    50                  55                  60                  


Ala Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
65                  70                  75                  80  


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
                85                  90                  95      


Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe 
            100                 105                 110         


Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val 
        115                 120                 125             


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp 
    130                 135                 140                 


Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys 
145                 150                 155                 160 


Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr 
                165                 170                 175     


Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr 
            180                 185                 190         


Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe 
        195                 200                 205             


Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala 
    210                 215                 220                 


His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 
225                 230                 235                 240 


Leu Tyr Tyr Leu Asn Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn 
                245                 250                 255     


Lys Asp Leu Leu Phe Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln 
            260                 265                 270         


Pro Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser 
        275                 280                 285             


Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala 
    290                 295                 300                 


Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr 
305                 310                 315                 320 


Ala Met Ala Ser His Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser 
                325                 330                 335     


Gly Val Met Ile Phe Gly Lys Glu Asn Ala Gly Ala Ser Asn Thr Ala 
            340                 345                 350         


Leu Asp Asn Val Met Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn 
        355                 360                 365             


Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Leu Gln Ser 
    370                 375                 380                 


Ser Asn Thr Asp Pro Ala Thr Gly Asp Val His Val Met Gly Ala Leu 
385                 390                 395                 400 


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
                405                 410                 415     


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
            420                 425                 430         


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
        435                 440                 445             


Asn Thr Pro Val Pro Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys 
    450                 455                 460                 


Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
465                 470                 475                 480 


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
                485                 490                 495     


Val Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr 
            500                 505                 510         


Val Asp Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg 
        515                 520                 525             


Tyr Leu Thr Arg Pro Leu 
    530                 


<210>  22
<211>  1605
<212>  DNA
<213>  adeno-associated virus rh91 VP3

<400>  22
atggcttcag gcggtggcgc accaatggca gacaataacg aaggcgccga cggagtgggt       60

aatgcctcag gaaattggca ttgcgattcc acatggctgg gcgacagagt catcaccacc      120

agcacccgaa cctgggccct tcctacctac aacaaccacc tctacaagca aatctccagc      180

gcttcaacgg gggccagtaa cgacaaccac tactttggct acagcacccc ctgggggtat      240

tttgatttca acagattcca ctgccacttc tcaccacgtg actggcagcg actcattaac      300

aacaactggg gattccggcc caagagactc aacttcaagc tcttcaacat ccaggtcaag      360

gaggtcacga cgaatgatgg cgtcacaacc atcgctaata accttaccag cacggttcaa      420

gtgttctcgg actcggagta ccagctgccg tacgtcctcg gttctgcgca ccagggctgc      480

ctccctccgt tcccggcgga cgtattcatg attcctcagt acggctacct aacgctcaac      540

aatggcagcc aggccgtagg acgttcatcc ttttattgcc tggaatattt cccatctcaa      600

atgctgagaa cgggcaacaa ctttaccttc agctacacct ttgaagatgt gcctttccac      660

agcagttacg cgcacagcca gagcctggac aggctaatga atcctctaat cgaccagtac      720

ctgtattacc taaacagaac tcagaatcaa tccggaagtg cacaaaacaa ggacttgctg      780

tttagccggg ggtctccagc tggcatgtct gttcagccca aaaactggct acccgggccc      840

tgttaccgac agcagcgtgt ttctaaaaca aaaacagaca acaacaacag caactttacc      900

tggactggtg cctccaaata caatctgaac ggacgtgaat ccatcattaa ccctggcacc      960

gctatggcat cccacaagga cgacgaagac aaattttttc ccatgagcgg tgttatgatt     1020

tttggcaaag aaaatgcagg agcatcaaac actgcattag acaatgttat gattacagat     1080

gaagaggaaa ttaaagctac caaccccgtg gccaccgaga gatttggaac tgtggcagtc     1140

aatctccaaa gcagcaatac agaccctgca acaggagacg tgcatgtcat gggggcttta     1200

cctggcatgg tgtggcaaga cagagacgtg tacctgcagg gtcccatttg ggccaagatt     1260

cctcacacgg atggacactt tcacccgtct cctcttatgg gcggctttgg acttaagcac     1320

ccgcctcctc agatcctcat caaaaacacg cctgttcctg cgaatcctcc ggcagagttt     1380

tcggctacaa agtttgcttc attcatcacc cagtactcca caggacaagt gagcgtggaa     1440

attgaatggg agctgcagaa agaaaacagt aagcgctgga atcctgaagt gcagtacacc     1500

tccaactacg cgaaatctgc caacgttgat ttcactgtgg acaacaatgg actttatact     1560

gagcctcgcc ccattggcac ccgttacctt acccgtcccc tttaa                     1605


<210>  23
<211>  1800
<212>  DNA
<213>  adeno-associated virus rh91 VP2

<400>  23
acggctcctg gaaagaagag gcctgtagag cagtctcctc aggaaccgga ctcatcatct       60

ggtattggca aatcgggcca gcagcctgcc aaaaaaagac taaatttcgg tcagactggc      120

gactcagagt cagtccccga ccctcaacct ctcggagaac ctccagaaac ccccgctgct      180

gtgggaccta ctacaatggc ttcaggcggt ggcgcaccaa tggcagacaa taacgaaggc      240

gccgacggag tgggtaatgc ctcaggaaat tggcattgcg attccacatg gctgggcgac      300

agagtcatca ccaccagcac ccgaacctgg gcccttccta cctacaacaa ccacctctac      360

aagcaaatct ccagcgcttc aacgggggcc agtaacgaca accactactt tggctacagc      420

accccctggg ggtattttga tttcaacaga ttccactgcc acttctcacc acgtgactgg      480

cagcgactca ttaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc      540

aacatccagg tcaaggaggt cacgacgaat gatggcgtca caaccatcgc taataacctt      600

accagcacgg ttcaagtgtt ctcggactcg gagtaccagc tgccgtacgt cctcggttct      660

gcgcaccagg gctgcctccc tccgttcccg gcggacgtat tcatgattcc tcagtatgga      720

tacctcaccc tgaacaacgg aagtcaagcg gtgggacgct catcctttta ctgcctggag      780

tacttccctt cgcagatgct aaggactgga aataacttca ccttcagcta taccttcgag      840

gatgtacctt ttcacagcag ctacgctcac agccagagtt tggatcgctt gatgaatcct      900

cttattgatc agtatctgta ctacctgaac agaacgcaaa atcaatctgg aagtgcacaa      960

aacaaggacc tgctttttag ccgggggtct cctgctggca tgtctgttca gcccaaaaat     1020

tggctacctg ggccctgcta ccggcaacag agagtttcaa agactaaaac agacaacaac     1080

aacagtaact ttacctggac aggtgccagc aaatataatc tcaatggccg cgaatcgatc     1140

attaatccag gaaccgctat ggccagtcac aaggacgatg aagacaaatt tttccctatg     1200

agcggcgtta tgatatttgg caaagaaaat gcaggagcaa gtaacactgc attagataat     1260

gtaatgatta cggatgaaga agagattaaa gctaccaatc ctgtggcaac agagagattt     1320

ggaactgtgg cagtcaactt gcagagctca aatacagacc ccgcaactgg agacgtccat     1380

gtcatggggg ccttacctgg catggtgtgg caagatcgtg acgtgtacct tcaaggacct     1440

atctgggcaa agattcctca cacggatgga cactttcatc cttctcctct gatgggaggc     1500

tttggactga aacatccgcc tcctcaaatc ctcatcaaaa atactccggt accggcaaat     1560

cctccggcag agttcagcgc tacaaagttt gcttcattta tcactcagta ctccactgga     1620

caggtcagcg tggaaattga gtgggagcta cagaaagaaa acagcaaacg ttggaatcca     1680

gaggtgcagt acacttccaa ctacgcgaag tctgccaatg tggactttac tgtagacaac     1740

aatggtcttt atactgaacc tcgccctatt ggaacccggt atctcacacg acccttgtaa     1800


<210>  24
<211>  1605
<212>  DNA
<213>  adeno-associated virus rh91 VP3

<400>  24
atggcttcag gcggtggcgc accaatggca gacaataacg aaggcgccga cggagtgggt       60

aatgcctcag gaaattggca ttgcgattcc acatggctgg gcgacagagt catcaccacc      120

agcacccgaa cctgggccct tcctacctac aacaaccacc tctacaagca aatctccagc      180

gcttcaacgg gggccagtaa cgacaaccac tactttggct acagcacccc ctgggggtat      240

tttgatttca acagattcca ctgccacttc tcaccacgtg actggcagcg actcattaac      300

aacaactggg gattccggcc caagagactc aacttcaagc tcttcaacat ccaggtcaag      360

gaggtcacga cgaatgatgg cgtcacaacc atcgctaata accttaccag cacggttcaa      420

gtgttctcgg actcggagta ccagctgccg tacgtcctcg gttctgcgca ccagggctgc      480

ctccctccgt tcccggcgga cgtattcatg attcctcagt atggatacct caccctgaac      540

aacggaagtc aagcggtggg acgctcatcc ttttactgcc tggagtactt cccttcgcag      600

atgctaagga ctggaaataa cttcaccttc agctatacct tcgaggatgt accttttcac      660

agcagctacg ctcacagcca gagtttggat cgcttgatga atcctcttat tgatcagtat      720

ctgtactacc tgaacagaac gcaaaatcaa tctggaagtg cacaaaacaa ggacctgctt      780

tttagccggg ggtctcctgc tggcatgtct gttcagccca aaaattggct acctgggccc      840

tgctaccggc aacagagagt ttcaaagact aaaacagaca acaacaacag taactttacc      900

tggacaggtg ccagcaaata taatctcaat ggccgcgaat cgatcattaa tccaggaacc      960

gctatggcca gtcacaagga cgatgaagac aaatttttcc ctatgagcgg cgttatgata     1020

tttggcaaag aaaatgcagg agcaagtaac actgcattag ataatgtaat gattacggat     1080

gaagaagaga ttaaagctac caatcctgtg gcaacagaga gatttggaac tgtggcagtc     1140

aacttgcaga gctcaaatac agaccccgca actggagacg tccatgtcat gggggcctta     1200

cctggcatgg tgtggcaaga tcgtgacgtg taccttcaag gacctatctg ggcaaagatt     1260

cctcacacgg atggacactt tcatccttct cctctgatgg gaggctttgg actgaaacat     1320

ccgcctcctc aaatcctcat caaaaatact ccggtaccgg caaatcctcc ggcagagttc     1380

agcgctacaa agtttgcttc atttatcact cagtactcca ctggacaggt cagcgtggaa     1440

attgagtggg agctacagaa agaaaacagc aaacgttgga atccagaggt gcagtacact     1500

tccaactacg cgaagtctgc caatgtggac tttactgtag acaacaatgg tctttatact     1560

gaacctcgcc ctattggaac ccggtatctc acacgaccct tgtaa                     1605


<210>  25
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid 56 to amino acid 210 of FXN

<400>  25

Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile Trp Asn Val Lys Lys Gln 
1               5                   10                  15      


Ser Val Tyr Leu Met Asn Leu Arg Lys Ser Gly Thr Leu Gly His Pro 
            20                  25                  30          


Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu 
        35                  40                  45              


Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr 
    50                  55                  60                  


Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly Val Leu Thr Val Lys 
65                  70                  75                  80  


Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn 
                85                  90                  95      


Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp 
            100                 105                 110         


Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp Gly Val Ser Leu His 
        115                 120                 125             


Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp 
    130                 135                 140                 


Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
145                 150                 155 


<210>  26
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid 78 to amino acid 210 of FXN

<400>  26

Leu Arg Lys Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr 
1               5                   10                  15      


Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe 
            20                  25                  30          


Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val 
        35                  40                  45              


Ser Phe Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly 
    50                  55                  60                  


Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser 
65                  70                  75                  80  


Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp 
                85                  90                  95      


Val Tyr Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu 
            100                 105                 110         


Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr 
        115                 120                 125             


Ser Gly Lys Asp Ala 
    130             


<210>  27
<211>  382
<212>  DNA
<213>  Human Cytomegalovirus Immediate-Early Enhancer (CMV IE)

<400>  27
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt ac                                               382


<210>  28
<211>  281
<212>  DNA
<213>  Chicken Beta-Actin Promoter

<400>  28
tggtcgaggt gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc       60

caattttgta tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg      120

gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg aggcggagag      180

gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc      240

ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc g                          281


<210>  29
<211>  973
<212>  DNA
<213>  Chimeric Intron

<400>  29
gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg       60

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc      120

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc      180

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc      240

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag      300

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg      360

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct      420

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg      480

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag      540

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc      600

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag      660

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc      720

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt      780

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc      840

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt      900

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat      960

cattttggca aag                                                         973


<210>  30
<211>  127
<212>  DNA
<213>  Rabbit Beta-Globin poly-Adenylation Signal

<400>  30
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


