                         SEQUENCE LISTING

<110>  Board of Regents, The University of Texas System
 
<120>  CROSS-REACTIVE ANTIBODIES RECOGNIZING THE CORONAVIRUS SPIKE S2 
       DOMAIN

<130>  UTFB.P1269WO

<140>  not yet known
<141>  2022-01-11

<150>  US 63/234,776
<151>  2021-08-19

<150>  US 63/135,913
<151>  2021-01-11

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  1

Gly Phe Asn Ile Lys Asp Thr Tyr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  2

Ile Gly Pro Ala Ile Gly Asn Thr 
1               5               


<210>  3
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  3

Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  4
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  4

Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  5
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  5

Arg Met Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  6

Met Gln Tyr Leu Glu Tyr Pro Leu Thr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  7

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  8

Ile Ser Ser Gly Gly Ser Tyr Thr 
1               5               


<210>  9
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  9

Ala Arg Asp Gly Tyr Gly Asn Tyr Val Gly Met Asp Tyr 
1               5                   10              


<210>  10
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  10

Ser Ser Val Ser Tyr 
1               5   


<210>  11
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  11

Ser Thr Ser 
1           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  12

Gln Gln Trp Ser Ser Asn Ser Tyr Thr 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  13

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  14

Ile Asp Pro Ser Asn Ser Glu Thr 
1               5               


<210>  15
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  15

Ala Arg Leu Gly Arg Tyr 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  16

Gln Asn Val Gly Ala Asn 
1               5       


<210>  17
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  17

Ser Ala Ser 
1           


<210>  18
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  18

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Ser Gly Gly Gly 
1               5                   10              


<210>  19
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  19

Phe Asn Ile Lys Asp Thr Tyr Ile His 
1               5                   


<210>  20
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  20

Trp Ile Gly Arg Ile Gly Pro Ala Ile Gly Asn Thr Ile Tyr Ala 
1               5                   10                  15  


<210>  21
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  21

Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  22

Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10              


<210>  23
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  23

Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser 
1               5                   10      


<210>  24
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  24

Met Gln Tyr Leu Glu Tyr Pro Leu 
1               5               


<210>  25
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  25

Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   


<210>  26
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  26

Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr 
1               5                   10                  


<210>  27
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  27

Arg Asp Gly Tyr Gly Asn Tyr Val Gly Met Asp Tyr 
1               5                   10          


<210>  28
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  28

Ser Ser Val Ser Tyr Met His 
1               5           


<210>  29
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  29

Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
1               5                   10      


<210>  30
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  30

Gln Gln Trp Ser Ser Asn Ser Tyr 
1               5               


<210>  31
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  31

Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   


<210>  32
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  32

Trp Val Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Arg Leu 
1               5                   10                  


<210>  33
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  33

Arg Leu Gly Arg Tyr 
1               5   


<210>  34
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  34

Gln Asn Val Gly Ala Asn Val Ala 
1               5               


<210>  35
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  35

Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
1               5                   10      


<210>  36
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  36

Gln Gln Tyr Asn Ser Tyr Pro Tyr 
1               5               


<210>  37
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  37

Gly Phe Asn Ile Lys Asp Thr 
1               5           


<210>  38
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  38

Gly Pro Ala Ile Gly Asn 
1               5       


<210>  39
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  39

Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  40
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  40

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  41
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  41

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  42

Met Gln Tyr Leu Glu Tyr Pro Leu Thr 
1               5                   


<210>  43
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  43

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  44
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  44

Ser Ser Gly Gly Ser Tyr 
1               5       


<210>  45
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  45

Asp Gly Tyr Gly Asn Tyr Val Gly Met Asp Tyr 
1               5                   10      


<210>  46
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  46

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  47
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  47

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  48

Gln Gln Trp Ser Ser Asn Ser Tyr Thr 
1               5                   


<210>  49
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  49

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  50
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  50

Asp Pro Ser Asn Ser Glu 
1               5       


<210>  51
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  51

Leu Gly Arg Tyr 
1               


<210>  52
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  52

Lys Ala Ser Gln Asn Val Gly Ala Asn Val Ala Trp Tyr 
1               5                   10              


<210>  53
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  53

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  54

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  55
<211>  469
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  55

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Leu Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Leu Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Gly Pro Ala Ile Gly Asn Thr Ile Tyr Ala 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  56
<211>  238
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  56

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Ala Pro Ser Val Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
        35                  40                  45              


Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr 
                85                  90                  95      


Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Met Gln Tyr Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  57
<211>  469
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  57

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Asn Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Gly Tyr Gly Asn Tyr Val Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  58
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  58

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              


Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu 
    50                  55                  60                  


Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
                85                  90                  95      


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
            100                 105                 110         


Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  59
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  59

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Arg Leu Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Arg Tyr Trp Gly Gln Gly Thr Thr Leu 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  60
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  60

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
            20                  25                  30          


Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val 
        35                  40                  45              


Gly Ala Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg 
65                  70                  75                  80  


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn 
                85                  90                  95      


Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  61
<211>  254
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  61

Met Arg Pro Thr Trp Ala Trp Trp Leu Phe Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Leu Trp Ala Pro Ala Arg Gly Gln Val Gln Leu Gln Gln Ser Gly Ala 
            20                  25                  30          


Glu Leu Leu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser 
        35                  40                  45              


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Leu Lys Gln Arg Pro 
    50                  55                  60                  


Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Gly Pro Ala Ile Gly Asn 
65                  70                  75                  80  


Thr Ile Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Thr Asp 
                85                  90                  95      


Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr 
        115                 120                 125             


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala 
145                 150                 155                 160 


Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
        195                 200                 205             


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr 
    210                 215                 220                 


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
225                 230                 235                 240 


Val Pro Arg Asp Cys Gly Lys Gly Leu Glu Val Leu Phe Gln 
                245                 250                 


<210>  62
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  62

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Ala Pro Ser Val Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
        35                  40                  45              


Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr 
                85                  90                  95      


Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Met Gln Tyr Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys Arg Thr Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  63
<211>  254
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  63

Met Arg Pro Thr Trp Ala Trp Trp Leu Phe Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Leu Trp Ala Pro Ala Arg Gly Glu Val Gln Val Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro 
    50                  55                  60                  


Asp Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr 
65                  70                  75                  80  


Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu 
            100                 105                 110         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Gly Tyr Gly Asn Tyr Val 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala 
145                 150                 155                 160 


Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
        195                 200                 205             


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr 
    210                 215                 220                 


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
225                 230                 235                 240 


Val Pro Arg Asp Cys Gly Lys Gly Leu Glu Val Leu Phe Gln 
                245                 250                 


<210>  64
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  64

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              


Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu 
    50                  55                  60                  


Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
                85                  90                  95      


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
            100                 105                 110         


Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  65
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  65

Met Arg Pro Thr Trp Ala Trp Trp Leu Phe Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Leu Trp Ala Pro Ala Arg Gly Gln Val Gln Leu Gln Gln Ser Gly Ala 
            20                  25                  30          


Glu Leu Ala Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Val Gly Met Ile Asp Pro Ser Asn Ser Glu 
65                  70                  75                  80  


Thr Arg Leu Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Asn Val Asp 
                85                  90                  95      


Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Leu Gly Arg Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Lys 
225                 230                 235                 240 


Gly Leu Glu Val Leu Phe Gln 
                245         


<210>  66
<211>  234
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  66

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
            20                  25                  30          


Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val 
        35                  40                  45              


Gly Ala Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg 
65                  70                  75                  80  


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn 
                85                  90                  95      


Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  67
<211>  1288
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  67

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1205                 1210                 1215             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1220                 1225                 1230             


Ser Thr  Phe Leu Gly Arg Ser  Leu Glu Val Leu Phe  Gln Gly Pro 
    1235                 1240                 1245             


Gly His  His His His His His  His His Ser Ala Trp  Ser His Pro 
    1250                 1255                 1260             


Gln Phe  Glu Lys Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1265                 1270                 1275             


Ser Ala  Trp Ser His Pro Gln  Phe Glu Lys 
    1280                 1285             


<210>  68
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Leu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Leu Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Gly Pro Ala Ile Gly Asn Thr Ile Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  69
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  69

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Tyr 
                85                  90                  95      


Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  70
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Gly Pro Ala Ile Gly Asn Thr Ile Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  71
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  71

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Tyr 
                85                  90                  95      


Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  72
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Gly Pro Ala Ile Gly Asn Thr Ile Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  73
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  73

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Gly Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Tyr 
                85                  90                  95      


Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  74
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Gly Pro Ala Ile Gly Asn Thr Ile Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  75
<211>  1288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 ectodomain with trimerization domain and tags at the C-terminus


<220>
<221>  MISC_FEATURE
<222>  (14)..(1208)
<223>  SARS-CoV-2 Ectodomain

<220>
<221>  MISC_FEATURE
<222>  (1209)..(1288)
<223>  Trimerization domain and tags

<400>  75

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1205                 1210                 1215             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1220                 1225                 1230             


Ser Thr  Phe Leu Gly Arg Ser  Leu Glu Val Leu Phe  Gln Gly Pro 
    1235                 1240                 1245             


Gly His  His His His His His  His His Ser Ala Trp  Ser His Pro 
    1250                 1255                 1260             


Gln Phe  Glu Lys Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1265                 1270                 1275             


Ser Ala  Trp Ser His Pro Gln  Phe Glu Lys 
    1280                 1285             


<210>  76
<211>  1208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 ectodomain consensus sequence for wild-type and variants


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Leu or Phe

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Ser or Ile

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Leu or Phe

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Thr or Arg

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Thr or Asn

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa is Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is His or absent

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa is Val or absent

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa is Asp, Gly, or Ala

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is Thr or Ile

<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  Xaa is Asp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (142)..(142)
<223>  Xaa is Gly or Asp

<220>
<221>  MISC_FEATURE
<222>  (144)..(144)
<223>  Xaa is Tyr or absent

<220>
<221>  MISC_FEATURE
<222>  (152)..(152)
<223>  Xaa is Trp or Cys

<220>
<221>  MISC_FEATURE
<222>  (154)..(154)
<223>  Xaa is Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (156)..(156)
<223>  Xaa is Glu or absent

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  Xaa is Phe, Ser, or absent

<220>
<221>  MISC_FEATURE
<222>  (158)..(158)
<223>  Xaa is Arg or Gly

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  Xaa is Arg or Ser

<220>
<221>  MISC_FEATURE
<222>  (215)..(215)
<223>  Xaa is Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (241)..(241)
<223>  Xaa is Leu or absent

<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Xaa is Leu or absent

<220>
<221>  MISC_FEATURE
<222>  (243)..(243)
<223>  Xaa is Ala or absent

<220>
<221>  MISC_FEATURE
<222>  (253)..(253)
<223>  Xaa is Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (417)..(417)
<223>  Xaa is Lys, Asn, or Thr

<220>
<221>  MISC_FEATURE
<222>  (452)..(452)
<223>  Xaa is Leu or Arg

<220>
<221>  MISC_FEATURE
<222>  (477)..(477)
<223>  Xaa is Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (478)..(478)
<223>  Xaa is Thr or Lys

<220>
<221>  MISC_FEATURE
<222>  (484)..(484)
<223>  Xaa is Glu, Lys, or Gln

<220>
<221>  MISC_FEATURE
<222>  (494)..(494)
<223>  Xaa is Ser or Pro

<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Xaa is Asn or Tyr

<220>
<221>  MISC_FEATURE
<222>  (565)..(565)
<223>  Xaa is Phe or Leu

<220>
<221>  MISC_FEATURE
<222>  (570)..(570)
<223>  Xaa is Ala or Asp

<220>
<221>  MISC_FEATURE
<222>  (614)..(614)
<223>  Xaa is Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (655)..(655)
<223>  Xaa is His or Tyr

<220>
<221>  MISC_FEATURE
<222>  (677)..(677)
<223>  Xaa is Gln or His

<220>
<221>  MISC_FEATURE
<222>  (681)..(681)
<223>  Xaa is Pro, His, or Arg

<220>
<221>  MISC_FEATURE
<222>  (701)..(701)
<223>  Xaa is Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (716)..(716)
<223>  Xaa is Thr or Ile

<220>
<221>  MISC_FEATURE
<222>  (791)..(791)
<223>  Xaa is Thr or Ile

<220>
<221>  MISC_FEATURE
<222>  (859)..(859)
<223>  Xaa is Thr or Asn

<220>
<221>  MISC_FEATURE
<222>  (888)..(888)
<223>  Xaa is Phe or Leu

<220>
<221>  MISC_FEATURE
<222>  (950)..(950)
<223>  Xaa is Asp, His, or Asn

<220>
<221>  MISC_FEATURE
<222>  (982)..(982)
<223>  Xaa is Ser or Ala

<220>
<221>  MISC_FEATURE
<222>  (1027)..(1027)
<223>  Xaa is Thr or Ile

<220>
<221>  MISC_FEATURE
<222>  (1071)..(1071)
<223>  Xaa is Gln or His

<220>
<221>  MISC_FEATURE
<222>  (1118)..(1118)
<223>  Xaa is Asp or His

<220>
<221>  MISC_FEATURE
<222>  (1176)..(1176)
<223>  Xaa is Val or Phe

<220>
<221>  MISC_FEATURE
<222>  (1191)..(1191)
<223>  Xaa is Lys or Asn

<400>  76

Met Phe Val Phe Xaa Val Leu Leu Pro Leu Val Ser Xaa Gln Cys Val 
1               5                   10                  15      


Asn Xaa Xaa Xaa Arg Thr Gln Leu Pro Xaa Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Xaa Ile Xaa Xaa Ser Gly Thr Asn Gly Thr Lys Arg Phe Xaa 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Xaa Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Xaa Pro Phe Leu Xaa Val Xaa 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Xaa Met Xaa Ser Xaa Xaa Xaa Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Xaa Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Xaa Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Xaa Xaa Xaa Leu His Arg Ser Tyr Leu Thr Pro Gly Xaa Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Xaa Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Xaa Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Xaa Xaa Pro Cys 
465                 470                 475                 480 


Asn Gly Val Xaa Gly Phe Asn Cys Tyr Phe Pro Leu Gln Xaa Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Xaa Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Xaa Gly Arg Asp Ile Xaa Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Xaa Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Xaa Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Xaa Thr Asn Ser Xaa Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Xaa Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Xaa Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Xaa Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Xaa Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Xaa Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Xaa Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Xaa Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Xaa Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Xaa Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Xaa Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Xaa Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Xaa Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln 
    1205             


<210>  77
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Ala Asp Val Leu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          


Tyr Ile His Trp Leu Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Gly Pro Ala Ile Gly Asn Thr Ile Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  78
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  78

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu His His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Asn Gly Thr Ala Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Tyr 
                85                  90                  95      


Leu Glu Tyr Pro Leu Thr Phe Asp Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  79
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  79

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Leu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Leu Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Gly Pro Ala Ile Gly Asn Thr Ile Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Tyr Ala Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  80
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  80

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Ala Arg Met Ser Thr Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Tyr 
                85                  90                  95      


Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  81

Gly Phe Asn Ile Lys Asn Thr Tyr 
1               5               


<210>  82
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  82

Ala Arg Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Leu Asp Tyr 
1               5                   10              


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  83

Lys Ser Leu His His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  84
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  84

Ala Arg Tyr Tyr Gly Tyr Ala Tyr Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  85

Phe Asn Ile Lys Asn Thr Tyr Ile His 
1               5                   


<210>  86
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  86

Lys Ser Leu His His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10              


<210>  87
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  87

Leu Leu Ile Ala Arg Met Ser Thr Leu Ala Ser 
1               5                   10      


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  88

Gly Phe Asn Ile Lys Asn Thr 
1               5           


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  89

Tyr Tyr Gly Ser Ser Tyr Tyr Tyr Leu Asp Tyr 
1               5                   10      


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  90

Arg Ser Ser Lys Ser Leu His His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  91

Tyr Tyr Gly Tyr Ala Tyr Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  92

Arg Met Ser Thr Leu Ala Ser 
1               5           


