                         SEQUENCE LISTING

<110>  CATALYST BIOSCIENCES, INC.
 
<120>  FACTOR B PROTEASES

<130>  CTBI-004/02WO 338308-2122

<140>  PCT/US2022/011873
<141>  2022-01-10

<150>  US 63/221,108
<151>  2021-07-13

<150>  US 63/135,496
<151>  2021-01-08

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  2

Lys Val Ser Glu Ala Asp 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  3

Gly Lys Lys Glu Ala Gly 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  4

Ile Arg Pro Ser Lys Gly 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  5

Gly Gly Glu Lys Arg Asp 
1               5       


<210>  6
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Ile Gly Gly Thr Glu Cys Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Glu Ile Val Thr Ser Asn Gly Pro Ser Lys Phe Cys Gly Gly 
            20                  25                  30          


Phe Leu Ile Arg Arg Asn Phe Val Leu Thr Ala Ala His Cys Ala Gly 
        35                  40                  45              


Arg Ser Ile Thr Val Thr Leu Gly Ala His Asn Ile Thr Glu Glu Glu 
    50                  55                  60                  


Asp Thr Trp Gln Lys Leu Glu Val Ile Lys Gln Phe Arg His Pro Lys 
65                  70                  75                  80  


Tyr Asn Thr Ser Thr Leu His His Asp Ile Met Leu Leu Lys Leu Lys 
                85                  90                  95      


Glu Lys Ala Ser Leu Thr Leu Ala Val Gly Thr Leu Pro Phe Pro Ser 
            100                 105                 110         


Gln Phe Asn Phe Val Pro Pro Gly Arg Met Cys Arg Val Ala Gly Trp 
        115                 120                 125             


Gly Arg Thr Gly Val Leu Lys Pro Gly Ser Asp Thr Leu Gln Glu Val 
    130                 135                 140                 


Lys Leu Arg Leu Met Asp Pro Gln Ala Cys Ser His Phe Arg Asp Phe 
145                 150                 155                 160 


Asp His Asn Leu Gln Leu Cys Val Gly Asn Pro Arg Lys Thr Lys Ser 
                165                 170                 175     


Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Ala Gly Val Ala 
            180                 185                 190         


Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp Ala Lys Pro Pro Ala Val 
        195                 200                 205             


Phe Thr Arg Ile Ser His Tyr Arg Pro Trp Ile Asn Gln Ile Leu Gln 
    210                 215                 220                 


Ala Asn 
225     


<210>  7
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Val Gly Gly Thr Asp Ala Asp Glu Gly Glu Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu His Ala Leu Gly Gln Gly His Ile Cys Gly Ala Ser Leu Ile 
            20                  25                  30          


Ser Pro Asn Trp Leu Val Ser Ala Ala His Cys Tyr Ile Asp Asp Arg 
        35                  40                  45              


Gly Phe Arg Tyr Ser Asp Pro Thr Gln Trp Thr Ala Phe Leu Gly Leu 
    50                  55                  60                  


His Asp Gln Ser Gln Arg Ser Ala Pro Gly Val Gln Glu Arg Arg Leu 
65                  70                  75                  80  


Lys Arg Ile Ile Ser His Pro Phe Phe Asn Asp Phe Thr Phe Asp Tyr 
                85                  90                  95      


Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro Ala Glu Tyr Ser Ser Met 
            100                 105                 110         


Val Arg Pro Ile Cys Leu Pro Asp Ala Ser His Val Phe Pro Ala Gly 
        115                 120                 125             


Lys Ala Ile Trp Val Thr Gly Trp Gly His Thr Gln Tyr Gly Gly Thr 
    130                 135                 140                 


Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile Arg Val Ile Asn Gln Thr 
145                 150                 155                 160 


Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile Thr Pro Arg Met Met Cys 
                165                 170                 175     


Val Gly Phe Leu Ser Gly Gly Val Asp Ser Cys Gln Gly Asp Ser Gly 
            180                 185                 190         


Gly Pro Leu Ser Ser Val Glu Ala Asp Gly Arg Ile Phe Gln Ala Gly 
        195                 200                 205             


Val Val Ser Trp Gly Asp Gly Cys Ala Gln Arg Asn Lys Pro Gly Val 
    210                 215                 220                 


Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp Ile Lys Glu Asn Thr Gly 
225                 230                 235                 240 


Val 
    


<210>  8
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp Cys Leu Asn Gly 
1               5                   10                  15      


Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile His Trp Cys Asn 
            20                  25                  30          


Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile Asp Lys Ser Lys 
        35                  40                  45              


Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly Lys Ala Ser Thr 
    50                  55                  60                  


Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser Ala Thr Val Leu 
65                  70                  75                  80  


Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu Gln Leu Gly Leu 
                85                  90                  95      


Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg Arg Arg Pro Trp 
            100                 105                 110         


Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln Glu Cys Met Val 
        115                 120                 125             


His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro Pro Glu Glu Leu 
    130                 135                 140                 


Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile Ile 
145                 150                 155                 160 


Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala Ile 
                165                 170                 175     


Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly Ser 
            180                 185                 190         


Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile Asp 
        195                 200                 205             


Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg Leu 
    210                 215                 220                 


Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu Ile 
225                 230                 235                 240 


Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp Ile 
                245                 250                 255     


Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro Ser 
            260                 265                 270         


Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro Gln 
        275                 280                 285             


Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser Thr 
    290                 295                 300                 


Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu Ile 
305                 310                 315                 320 


Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val Thr 
                325                 330                 335     


Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser Cys 
            340                 345                 350         


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg Met 
        355                 360                 365             


Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys Asp 
    370                 375                 380                 


Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile Arg 
385                 390                 395                 400 


Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
                405                 410     


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  9

Gln Gln Lys Arg Lys Ile Val 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  10

Trp Glu His Arg Lys Gly Thr 
1               5           


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  11

Lys Asn Gln Lys Arg Gln Lys Gln 
1               5               


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  12

Asp Val Phe Tyr Gln Met Ile 
1               5           


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  13

Glu Gly Val Asp Ala Glu 
1               5       


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  14

Asp His Lys Leu Lys Ser Gly 
1               5           


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  15

Thr Pro Trp Ser Leu Ala 
1               5       


<210>  16

<400>  16
000

<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to CPQ2 quencher

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Conjugated to 5FAM fluorescent reagent

<220>
<221>  SITE
<222>  (8)..(9)
<223>  linked by PEG8 polymer of ethylene glycol

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  amidated

<400>  17

Ile Thr Leu Leu Ser Ala Lys Lys Lys 
1               5                   


<210>  18
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu Lys Val Asn Gly Leu 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Val Lys Lys Val Glu 
        35                  40                  45              


Lys His Gly Pro Gly Arg Trp Val Val Leu Ala Ala Val Leu Ile Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu Val Trp His Leu Gln 
65                  70                  75                  80  


Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu 
                165                 170                 175     


Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val 
            180                 185                 190         


Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys Thr Val Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu His Ala Arg Gly Val Glu 
    210                 215                 220                 


Leu Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly 
            260                 265                 270         


Ser Asp Leu Val Thr Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Leu Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe His Ser Ser Gln Asn Val Leu Leu Ile Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Glu Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg 
                325                 330                 335     


Met Ser Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp 
        355                 360                 365             


Asn Ile Glu Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe 
    370                 375                 380                 


Phe Tyr Leu Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Thr Ser Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp 
            420                 425                 430         


Gln Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Ser Asp Pro Cys Pro Gly Gln Phe Thr Cys Arg Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp Cys Thr Asp His 
465                 470                 475                 480 


Ser Asp Glu Leu Asn Cys Ser Cys Asp Ala Gly His Gln Phe Thr Cys 
                485                 490                 495     


Lys Asn Lys Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn 
            500                 505                 510         


Asp Cys Gly Asp Asn Ser Asp Glu Gln Gly Cys Ser Cys Pro Ala Gln 
        515                 520                 525             


Thr Phe Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys Ser Gln Gln Cys 
    530                 535                 540                 


Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Pro 
545                 550                 555                 560 


Lys Val Asn Val Val Thr Cys Thr Lys His Thr Tyr Arg Cys Leu Asn 
                565                 570                 575     


Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Glu Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asp Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Arg Gln Ala Arg Val Val Gly Gly Thr Asp Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Ile 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Tyr Ile Asp Asp Arg Gly Phe Arg Tyr Ser Asp Pro Thr Gln Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu His Asp Gln Ser Gln Arg Ser Ala Pro Gly 
        675                 680                 685             


Val Gln Glu Arg Arg Leu Lys Arg Ile Ile Ser His Pro Phe Phe Asn 
    690                 695                 700                 


Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro 
705                 710                 715                 720 


Ala Glu Tyr Ser Ser Met Val Arg Pro Ile Cys Leu Pro Asp Ala Ser 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Gln Tyr Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Ala Asp Gly 
                805                 810                 815     


Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu Asn Thr Gly Val 
    850                 855 


<210>  19
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Cys Gly Val Pro Ala Ile His Pro Val Leu Ser Gly Leu Ser 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asp Ala Val Pro Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Glu Asp Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr 
65                  70                  75                  80  


Ser Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu 
                85                  90                  95      


Asn Ile Gln Val Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe 
            100                 105                 110         


Ser Ile Leu Thr Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr 
        115                 120                 125             


Pro Ala Arg Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala 
    130                 135                 140                 


Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly 
145                 150                 155                 160 


Lys Thr Lys Tyr Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala 
                165                 170                 175     


Ala Leu Pro Leu Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg 
            180                 185                 190         


Arg Ile Thr Asp Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser 
        195                 200                 205             


Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Ala 
    210                 215                 220                 


Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Asp Thr Cys Ser Thr 
225                 230                 235                 240 


Ser Ser Pro Gly Val Tyr Ala Arg Val Thr Lys Leu Ile Pro Trp Val 
                245                 250                 255     


Gln Lys Ile Leu Ala Ala Asn 
            260             


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  20

Lys Val Ser Glu Ala Asp 
1               5       


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  21

Asp His Lys Leu Lys Ser Gly 
1               5           


<210>  22
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala 
1               5                   10                  15      


Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly 
            20                  25                  30          


Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe 
        35                  40                  45              


Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser 
    50                  55                  60                  


Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn 
65                  70                  75                  80  


Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn 
                85                  90                  95      


Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln 
            100                 105                 110         


Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp 
        115                 120                 125             


Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn 
    130                 135                 140                 


Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys 
145                 150                 155                 160 


Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu 
                165                 170                 175     


Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp 
            180                 185                 190         


Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly 
        195                 200                 205             


Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu 
    210                 215                 220                 


Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp 
225                 230                 235                 240 


Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala 
                245                 250         


<210>  23
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  23

Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp Gln Ala 
1               5                   10                  15      


Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val Leu Val 
            20                  25                  30          


His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys Val Phe 
        35                  40                  45              


Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu Ser Gly 
    50                  55                  60                  


Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly Tyr Ser 
65                  70                  75                  80  


His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn Arg Arg 
                85                  90                  95      


Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys 
            100                 105                 110         


Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr Thr Lys 
        115                 120                 125             


Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Ser 
    130                 135                 140                 


Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln Ile Asp 
145                 150                 155                 160 


Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser Cys Gln 
                165                 170                 175     


Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln Gly Leu 
            180                 185                 190         


Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro Gly Val 
        195                 200                 205             


Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr Ile Gln 
    210                 215                 220                 


Ala Asn Ser 
225         


<210>  24
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Gly Ser His His His His His His Gly Ser Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Ile Ile Gly Gly Thr Glu Cys Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Glu Ile Val Thr Ser Asn Gly Pro Ser Lys 
        35                  40                  45              


Phe Cys Gly Gly Phe Leu Ile Arg Arg Asn Phe Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ala Gly Arg Ser Ile Thr Val Thr Leu Gly Ala His Asn Ile 
65                  70                  75                  80  


Thr Glu Glu Glu Asp Thr Trp Gln Lys Leu Glu Val Ile Lys Gln Phe 
                85                  90                  95      


Arg His Pro Lys Tyr Asn Thr Ser Thr Leu His His Asp Ile Met Leu 
            100                 105                 110         


Leu Lys Leu Lys Glu Lys Ala Ser Leu Thr Leu Ala Val Gly Thr Leu 
        115                 120                 125             


Pro Phe Pro Ser Gln Phe Asn Phe Val Pro Pro Gly Arg Met Cys Arg 
    130                 135                 140                 


Val Ala Gly Trp Gly Arg Thr Gly Val Leu Lys Pro Gly Ser Asp Thr 
145                 150                 155                 160 


Leu Gln Glu Val Lys Leu Arg Leu Met Asp Pro Gln Ala Cys Ser His 
                165                 170                 175     


Phe Arg Asp Phe Asp His Asn Leu Gln Leu Cys Val Gly Asn Pro Arg 
            180                 185                 190         


Lys Thr Lys Ser Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys 
        195                 200                 205             


Ala Gly Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp Ala Lys 
    210                 215                 220                 


Pro Pro Ala Val Phe Thr Arg Ile Ser His Tyr Arg Pro Trp Ile Asn 
225                 230                 235                 240 


Gln Ile Leu Gln Ala Asn 
                245     


<210>  25
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Arg Gly Ser His His His His His His Gly Ser Asp Glu Lys Asp 
1               5                   10                  15      


Ser Asp Ser Gly Leu Arg Ser Phe Thr Arg Gln Ala Arg Val Val Gly 
            20                  25                  30          


Gly Thr Asp Ala Asp Glu Gly Glu Trp Pro Trp Gln Val Ser Leu His 
        35                  40                  45              


Ala Leu Gly Gln Gly His Ile Cys Gly Ala Ser Leu Ile Ser Pro Asn 
    50                  55                  60                  


Trp Leu Val Ser Ala Ala His Cys Tyr Ile Asp Asp Arg Gly Phe Arg 
65                  70                  75                  80  


Tyr Ser Asp Pro Thr Gln Trp Thr Ala Phe Leu Gly Leu His Asp Gln 
                85                  90                  95      


Ser Gln Arg Ser Ala Pro Gly Val Gln Glu Arg Arg Leu Lys Arg Ile 
            100                 105                 110         


Ile Ser His Pro Phe Phe Asn Asp Phe Thr Phe Asp Tyr Asp Ile Ala 
        115                 120                 125             


Leu Leu Glu Leu Glu Lys Pro Ala Glu Tyr Ser Ser Met Val Arg Pro 
    130                 135                 140                 


Ile Cys Leu Pro Asp Ala Ser His Val Phe Pro Ala Gly Lys Ala Ile 
145                 150                 155                 160 


Trp Val Thr Gly Trp Gly His Thr Gln Tyr Gly Gly Thr Gly Ala Leu 
                165                 170                 175     


Ile Leu Gln Lys Gly Glu Ile Arg Val Ile Asn Gln Thr Thr Cys Glu 
            180                 185                 190         


Asn Leu Leu Pro Gln Gln Ile Thr Pro Arg Met Met Cys Val Gly Phe 
        195                 200                 205             


Leu Ser Gly Gly Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu 
    210                 215                 220                 


Ser Ser Val Glu Ala Asp Gly Arg Ile Phe Gln Ala Gly Val Val Ser 
225                 230                 235                 240 


Trp Gly Asp Gly Cys Ala Gln Arg Asn Lys Pro Gly Val Tyr Thr Arg 
                245                 250                 255     


Leu Pro Leu Phe Arg Asp Trp Ile Lys Glu Asn Thr Gly Val 
            260                 265                 270 


<210>  26
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln 
            20                  25                  30          


Pro Trp Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr 
        35                  40                  45              


Tyr Val Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala 
    50                  55                  60                  


Thr His Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr 
65                  70                  75                  80  


Leu Gly Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe 
                85                  90                  95      


Glu Val Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu 
            100                 105                 110         


Ala His His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly 
        115                 120                 125             


Arg Cys Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser 
    130                 135                 140                 


Met Tyr Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe 
145                 150                 155                 160 


Gly Lys Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met 
                165                 170                 175     


Thr Val Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr 
            180                 185                 190         


Tyr Gly Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln 
        195                 200                 205             


Trp Lys Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
    210                 215                 220                 


Ser Leu Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg 
225                 230                 235                 240 


Gly Cys Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His 
                245                 250                 255     


Phe Leu Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala 
            260                 265                 270         


Leu 
    


<210>  27
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  28
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  28

Val Thr Glu His Val Leu Ala Asn Asn Asp Val Ser Cys Asp His Pro 
1               5                   10                  15      


Ser Asn Thr Val Pro Ser Gly Ser Asn Gln Asp Leu Gly Ala Gly Ala 
            20                  25                  30          


Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser Ser Arg Ile Ile Asn Gly 
        35                  40                  45              


Ser Asp Cys Asp Met His Thr Gln Pro Trp Gln Ala Ala Leu Leu Leu 
    50                  55                  60                  


Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val Leu Val His Pro Gln Trp 
65                  70                  75                  80  


Leu Leu Thr Ala Ala His Cys Arg Lys Lys Val Phe Arg Val Arg Leu 
                85                  90                  95      


Gly His Tyr Ser Leu Ser Pro Val Tyr Glu Ser Gly Gln Gln Met Phe 
            100                 105                 110         


Gln Gly Val Lys Ser Ile Pro His Pro Gly Tyr Ser His Pro Gly His 
        115                 120                 125             


Ser Asn Asp Leu Met Leu Ile Lys Leu Asn Arg Arg Ile Arg Pro Thr 
    130                 135                 140                 


Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys Pro Ser Ala Gly 
145                 150                 155                 160 


Thr Lys Cys Leu Val Ser Gly Trp Gly Thr Thr Lys Ser Pro Gln Val 
                165                 170                 175     


His Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Ser Val Leu Ser Gln 
            180                 185                 190         


Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln Ile Asp Asp Thr Met Phe 
        195                 200                 205             


Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly 
    210                 215                 220                 


Gly Pro Val Val Cys Asn Gly Ser Leu Gln Gly Leu Val Ser Trp Gly 
225                 230                 235                 240 


Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro Gly Val Tyr Thr Asn Leu 
                245                 250                 255     


Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr Ile Gln Ala Asn Ser 
            260                 265                 270     


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to TQ2 quencher

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Conjugated to 5FAM fluorescent reagent

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  amidated

<400>  29

Lys Asp Val Phe Tyr Gln Met Lys Lys Lys 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to TQ2 quencher

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Conjugated to 5FAM fluorescent reagent

<400>  30

Lys Asp Val Phe Tyr Gln Met Lys Lys Lys 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to 5FAM fluorescent reagent

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Conjugated to QXL520 quencher

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  amidated

<400>  31

Glu Gln Gln Lys Arg Lys Ile Val Leu Lys 
1               5                   10  


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to CPQ2 quencher

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Conjugated to 5FAM fluorescent reagent

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  amidated

<400>  32

Pro Glu Gln Gln Lys Arg Lys 
1               5           


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to TQ2 quencher

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Conjugated to 5FAM fluorescent reagent

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  amidated

<400>  33

Gly Glu Gln Gln Lys Arg Lys Ile Val Leu Lys 
1               5                   10      


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  acetylated

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  conjugated to 7-amino-4-carbamoylmethylcoumarin

<400>  34

Gln Gln Lys Arg 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  35

Glu Gly Val Asp 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  36

Gln Gln Lys Arg 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  37

Asp Val Phe Tyr 
1               


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  38

Lys Asn Gln Lys Arg 
1               5   


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  acetylated

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  conjugated to 7-amino-4-carbamoylmethylcoumarin

<400>  39

Glu Gly Val Asp 
1               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to CPQ2 quencher

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Conjugated to 5FAM fluorescent reagent

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  amidated

<400>  40

Glu Gly Val Asp Ala Glu Lys Lys 
1               5               


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to biotin

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Conjugated to tetramethylrhodamine (TAMRA) azide

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  amidated

<400>  41

Gly Gly Gly Leu Ser Ser Leu Thr Glu Thr Ile Glu Gly Val Asp Ala 
1               5                   10                  15      


Glu Lys 
        


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to CPQ2 quencher

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Conjugated to 5FAM fluorescent reagent

<220>
<221>  SITE
<222>  (8)..(9)
<223>  linked by PEG8 polymer of ethylene glycol

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Conjugated to biotin

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  amidated

<400>  42

Glu Gly Val Asp Ala Glu Lys Lys Lys 
1               5                   


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  acetylated

<220>
<221>  SITE
<222>  (4)..(4)
<223>  conjugated to 7-amino-4-carbamoylmethylcoumarin

<400>  43

Trp Glu His Arg 
1               


<210>  44
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  acetylated

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  conjugated to 7-amino-4-carbamoylmethylcoumarin

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  conjugated to a trifluoroacetic acid salt

<400>  44

Lys Asn Gln Lys 
1               


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  conjugated to a TQ2 quencher

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  conjugated to a 5FAM fluorescent reagent

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  amidated

<400>  45

Lys Asn Gln Lys Arg Gln Lys Gln Lys 
1               5                   


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  acetylated

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  conjugated to 7-amino-4-carbamoylmethylcoumarin

<400>  46

Lys Asn Gln Lys 
1               


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  conjugated to a 5FAM fluorescent reagent

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  amidated

<400>  47

Trp Ser His Pro Gln Phe Glu Lys Lys Asn Gln Lys Arg Gln Lys Gln 
1               5                   10                  15      


Lys 
    


<210>  48
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  conjugated to 7-amino-4-carbamoylmethylcoumarin

<400>  48

Gln Gln Lys Arg 
1               


<210>  49
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  conjugated to 7-amino-4-carbamoylmethylcoumarin

<400>  49

Gly Leu Ala Arg 
1               


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  conjugated to 5-carboxy-fluorescein-L-Lysine

<400>  50

Gln Gln Lys Arg Lys Ile 
1               5       


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  conjugated to 7-amino-4-carbamoylmethylcoumarin

<400>  51

Gln His Arg Arg 
1               


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  conjugated to 5-carboxy-fluorescein-L-Lysine

<400>  52

Glu Gly Val Asp Ala Glu 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate

<400>  53

Glu Gly Val Asp Ala Glu 
1               5       


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  conjugated to 7-amino-4-carbamoylmethylcoumarin

<400>  54

Arg Gln Ala Arg 
1               


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  conjugated to 5-carboxy-fluorescein-L-Lysine

<400>  55

Asp Val Phe Tyr Gln Met 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide substrate


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  conjugated to 5-carboxy-fluorescein-L-Lysine

<400>  56

Asn Val Phe Tyr Gln Met 
1               5       


