                         SEQUENCE LISTING

<110>  Arbor Biotechnologies
 
<120>  COMPOSITIONS COMPRISING A VARIANT POLYPEPTIDE AND USES THEREOF

<130>  381834-7003WO1(00012)

<150>  63/135,090
<151>  2021-01-08

<150>  63/135,108
<151>  2021-01-08

<150>  63/135,124
<151>  2021-01-08

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  2319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  parent nuclease nt sequence

<400>  1
atgtctgaga tcacagacct gctgaaggcc aatttcaagg ggaaaacttt taaaagtgcc       60

gatatgagaa tggctggcag gatcctgaag aaatcagggg cacaggccgt cattaagtac      120

ctgagcgaca aaggagccgt tgacccccct gatttcagac caccggcaaa gtgcaacatc      180

attgcccaga gtaggccttt tgatgagtgg ccaatctgta aggcttcaat ggcaatccag      240

cagcatatct acggactgac caaaaatgaa ttcgacgaga gctccccagg caccagcagc      300

gccagccacg agcagtggtt tgccaagact ggagtcgata cccacggctt cacccatgtt      360

cagggcctga acctgatctt tcagcatgcc aagaaacgct acgaaggagt cattaagaaa      420

gttgagaact acaacgaaaa ggagcggaag aaatttgaag gaatcaatga gcggagaagc      480

aaagagggta tgccactgct ggagcctcgg ctgcgtactg ccttcggcga cgatgggaag      540

tttgctgaga aaccaggcgt gaacccgagc atctacctgt atcagcagac atccccacgg      600

ccgtacgaca agactaaaca cccctatgtg catgcccctt tcgaactgaa ggagatcacc      660

acaattccca cccaggacga tagactgaag atcccctttg gagcccctgg tcacgtgcca      720

gagaaacata ggtcacagct gagcatggct aagcacaaaa ggcgccgagc ctggtacgct      780

ctgagccaga acaagccacg tccacctaag gacggttcaa aaggccggcg gagcgtgcgg      840

gacctggcag acctgaaagc agcttctctg gctgatgcaa tccctctggt gagccgggtg      900

ggattcgact gggtggtcat tgatggacgc ggtctgctcc gaaacctgag atggaggaag      960

ctcgcccatg aaggcatgac cgtggaggaa atgctgggct tcttttctgg ggaccccgtg     1020

atcgatccca gaaggaatgt ggccaccttc atctacaagg cagagcacgc cacagtgaag     1080

agccgtaaac caatcggtgg tgctaagcgt gcacgagagg aactgctgaa ggccacagct     1140

tcaagcgacg gagtgatccg ccaggtcggt ctgattagcg tggacctggg ccagactaac     1200

cctgtcgcct atgaaatctc ccggatgcat caggctaatg gcgagctggt cgcagaacac     1260

ctggagtacg ggctgctgaa cgacgagcaa gtgaatagca ttcagcggta ccgggcagcc     1320

tgggatagca tgaatgaatc cttccgccag aaggccatcg agtctctgag tatggaagct     1380

caggacgaga ttatgcaggc atccacaggc gctgcaaaaa gaactaggga agctgtgctg     1440

accatgttcg gtccaaacgc caccctgcca tggtcccgta tgtcctctaa tactacctgc     1500

atctctgacg ccctgattga ggttggaaag gaggaagaga ctaactttgt gacctccaat     1560

ggccctcgca aacgaactga tgctcagtgg gccgcttacc tgcgtcctcg ggtgaaccca     1620

gagacccggg ccctgctgaa ccaggccgtc tgggacctga tgaagaggag tgatgaatat     1680

gagcggctgt caaagagaaa actggagatg gcccgccagt gcgtgaactt cgttgtggca     1740

cgggccgaaa agctgacaca gtgtaacaat atcggcattg tgctggagaa cctggtggtg     1800

cggaattttc acggctccgg gcgccgagaa tctggatggg agggcttctt cgaaccaaag     1860

cgtgagaatc ggtggttcat gcaggtgctg cacaaagctt tttctgacct ggcacagcat     1920

aggggcgtga tggtcttcga ggtccacccc gcatacagtt cacagacctg ccctgcctgt     1980

agatatgtgg acccaaagaa caggagctcc gaagatagag agaggttcaa gtgcctgaaa     2040

tgtgggcgca gctttaacgc cgaccgagaa gttgctactt tcaatatcag ggagattgca     2100

cgcaccggag tcggtctgcc caagcctgat tgtgagcgca gccgaggcgt gcagacaact     2160

gggaccgctc gaaaccctgg acggtccctg aagtctaaca aaaatccatc cgaaccgaag     2220

cacgtgctga gatctaaaac aaggagtaac atcaccagta cactgtcaca gaatgagcca     2280

ctcgccacag atcagaagac tgctccgaaa accgggccc                            2319


<210>  2
<211>  2319
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  parent nuclease nt sequence

<400>  2
atgagcgaaa tcaccgacct gttgaaggcg aacttcaagg gtaaaacctt taaaagcgcg       60

gatatgcgca tggctggtcg tatcctgaag aaaagcggcg cgcaggcggt tatcaagtat      120

ctgtccgaca aaggtgcagt tgacccgccg gatttccgtc cgccggcaaa gtgcaacatc      180

attgctcaaa gccgtccgtt tgatgaatgg ccgatttgta aggcgagcat ggctatccag      240

caacatattt atggtctgac caaaaatgag ttcgatgaga gcagcccggg caccagcagc      300

gcaagccacg agcagtggtt tgccaaaacc ggtgttgata cgcacggctt cacccatgtc      360

cagggtctga acttgatctt tcaacatgcg aagaaacgtt acgaaggtgt gatcaagaag      420

gtggagaact acaacgaaaa ggagcgtaag aaattcgaag gtatcaacga gcgtcgcagc      480

aaagaaggca tgccgctgct ggagccgcgt ctgcgtaccg cgttcggtga cgatggcaag      540

tttgctgaaa aaccgggtgt taacccgagc atttacctgt atcagcaaac gagcccgcgt      600

ccgtacgaca agaccaaaca cccgtatgtg catgcgccgt tcgaactgaa ggagatcacc      660

acgattccga cccaggacga tcgtctgaag attccgtttg gtgcgccggg tcatgttccg      720

gagaaacatc gtagccagct gagcatggcg aagcacaaac gtcgccgtgc atggtacgcc      780

ctgagccaaa acaagccgcg tccgccgaag gacggtagca agggtcgccg tagcgtgcgt      840

gacctggcag atttgaaagc agcgagcctg gcagatgcaa tcccgctggt gagccgtgtg      900

ggtttcgact gggtggttat tgatggtcgc ggcctgttgc gtaacctgcg ctggcgtaag      960

ctggcgcatg aaggcatgac cgttgaggaa atgctgggtt tctttagcgg tgacccggtt     1020

atcgatccgc gccgtaatgt ggcgaccttt atttacaaag cggagcacgc taccgtgaag     1080

agccgtaaac cgatcggtgg tgcgaagcgt gcgcgtgagg aactgttgaa agcgaccgcg     1140

agcagcgacg gtgtgatccg tcaggttggc ctgattagcg tggatttggg tcaaaccaac     1200

ccggttgcgt atgaaatcag ccgtatgcat caggcaaatg gcgagctggt tgccgaacac     1260

ctggagtacg gcctgttgaa cgacgagcaa gtgaatagca ttcaacgcta tcgtgcagcc     1320

tgggattcta tgaacgagag cttccgtcaa aaggcgatcg agagcctgtc catggaagct     1380

caggacgaga ttatgcaggc gagcaccggt gcagctaaac gtacccgtga ggcagttctg     1440

accatgtttg gtccgaacgc aaccctgccg tggagccgta tgagcagcaa taccacgtgc     1500

atcagcgacg cgctgattga ggtcggtaaa gaggaagaaa ccaactttgt taccagcaat     1560

ggcccgcgca aacgtaccga tgcacagtgg gcagcatatc tgcgcccgcg tgtgaacccg     1620

gaaacccgtg cgctgttgaa tcaagccgtt tgggacctga tgaagcgttc cgatgaatat     1680

gagcgcctgt ctaagcgtaa gctggagatg gcgcgccagt gcgttaactt cgtcgtggcg     1740

cgtgcggaaa aactgaccca atgtaacaat atcggtattg tgctggagaa cttggtggtg     1800

cgtaattttc acggtagcgg tcgccgtgaa agcggttggg agggcttctt tgaaccgaag     1860

cgcgagaacc gttggttcat gcaggttctg cacaaagcgt ttagcgacct ggctcaacat     1920

cgtggtgtga tggttttcga agttcatccg gcatacagca gccagacctg cccggcttgt     1980

cgctatgtgg acccgaagaa ccgtagcagc gaagatcgcg agcgtttcaa gtgcctgaaa     2040

tgtggccgca gctttaacgc agaccgtgaa gtggccacct tcaatatccg cgagattgcg     2100

cgtaccggtg ttggcctgcc gaagccggat tgcgagcgca gccgtggtgt gcaaaccacc     2160

ggcaccgcac gtaacccggg tcgtagcctg aagtctaaca aaaatccgag cgaaccgaag     2220

cacgtgctgc gctccaaaac ccgttctaac atcaccagca cgctgtccca gaatgagccg     2280

ttggcgacgg atcaaaagac cgctccgaaa acgggcccg                            2319


<210>  3
<211>  773
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  parent nuclease aa sequence

<400>  3

Met Ser Glu Ile Thr Asp Leu Leu Lys Ala Asn Phe Lys Gly Lys Thr 
1               5                   10                  15      


Phe Lys Ser Ala Asp Met Arg Met Ala Gly Arg Ile Leu Lys Lys Ser 
            20                  25                  30          


Gly Ala Gln Ala Val Ile Lys Tyr Leu Ser Asp Lys Gly Ala Val Asp 
        35                  40                  45              


Pro Pro Asp Phe Arg Pro Pro Ala Lys Cys Asn Ile Ile Ala Gln Ser 
    50                  55                  60                  


Arg Pro Phe Asp Glu Trp Pro Ile Cys Lys Ala Ser Met Ala Ile Gln 
65                  70                  75                  80  


Gln His Ile Tyr Gly Leu Thr Lys Asn Glu Phe Asp Glu Ser Ser Pro 
                85                  90                  95      


Gly Thr Ser Ser Ala Ser His Glu Gln Trp Phe Ala Lys Thr Gly Val 
            100                 105                 110         


Asp Thr His Gly Phe Thr His Val Gln Gly Leu Asn Leu Ile Phe Gln 
        115                 120                 125             


His Ala Lys Lys Arg Tyr Glu Gly Val Ile Lys Lys Val Glu Asn Tyr 
    130                 135                 140                 


Asn Glu Lys Glu Arg Lys Lys Phe Glu Gly Ile Asn Glu Arg Arg Ser 
145                 150                 155                 160 


Lys Glu Gly Met Pro Leu Leu Glu Pro Arg Leu Arg Thr Ala Phe Gly 
                165                 170                 175     


Asp Asp Gly Lys Phe Ala Glu Lys Pro Gly Val Asn Pro Ser Ile Tyr 
            180                 185                 190         


Leu Tyr Gln Gln Thr Ser Pro Arg Pro Tyr Asp Lys Thr Lys His Pro 
        195                 200                 205             


Tyr Val His Ala Pro Phe Glu Leu Lys Glu Ile Thr Thr Ile Pro Thr 
    210                 215                 220                 


Gln Asp Asp Arg Leu Lys Ile Pro Phe Gly Ala Pro Gly His Val Pro 
225                 230                 235                 240 


Glu Lys His Arg Ser Gln Leu Ser Met Ala Lys His Lys Arg Arg Arg 
                245                 250                 255     


Ala Trp Tyr Ala Leu Ser Gln Asn Lys Pro Arg Pro Pro Lys Asp Gly 
            260                 265                 270         


Ser Lys Gly Arg Arg Ser Val Arg Asp Leu Ala Asp Leu Lys Ala Ala 
        275                 280                 285             


Ser Leu Ala Asp Ala Ile Pro Leu Val Ser Arg Val Gly Phe Asp Trp 
    290                 295                 300                 


Val Val Ile Asp Gly Arg Gly Leu Leu Arg Asn Leu Arg Trp Arg Lys 
305                 310                 315                 320 


Leu Ala His Glu Gly Met Thr Val Glu Glu Met Leu Gly Phe Phe Ser 
                325                 330                 335     


Gly Asp Pro Val Ile Asp Pro Arg Arg Asn Val Ala Thr Phe Ile Tyr 
            340                 345                 350         


Lys Ala Glu His Ala Thr Val Lys Ser Arg Lys Pro Ile Gly Gly Ala 
        355                 360                 365             


Lys Arg Ala Arg Glu Glu Leu Leu Lys Ala Thr Ala Ser Ser Asp Gly 
    370                 375                 380                 


Val Ile Arg Gln Val Gly Leu Ile Ser Val Asp Leu Gly Gln Thr Asn 
385                 390                 395                 400 


Pro Val Ala Tyr Glu Ile Ser Arg Met His Gln Ala Asn Gly Glu Leu 
                405                 410                 415     


Val Ala Glu His Leu Glu Tyr Gly Leu Leu Asn Asp Glu Gln Val Asn 
            420                 425                 430         


Ser Ile Gln Arg Tyr Arg Ala Ala Trp Asp Ser Met Asn Glu Ser Phe 
        435                 440                 445             


Arg Gln Lys Ala Ile Glu Ser Leu Ser Met Glu Ala Gln Asp Glu Ile 
    450                 455                 460                 


Met Gln Ala Ser Thr Gly Ala Ala Lys Arg Thr Arg Glu Ala Val Leu 
465                 470                 475                 480 


Thr Met Phe Gly Pro Asn Ala Thr Leu Pro Trp Ser Arg Met Ser Ser 
                485                 490                 495     


Asn Thr Thr Cys Ile Ser Asp Ala Leu Ile Glu Val Gly Lys Glu Glu 
            500                 505                 510         


Glu Thr Asn Phe Val Thr Ser Asn Gly Pro Arg Lys Arg Thr Asp Ala 
        515                 520                 525             


Gln Trp Ala Ala Tyr Leu Arg Pro Arg Val Asn Pro Glu Thr Arg Ala 
    530                 535                 540                 


Leu Leu Asn Gln Ala Val Trp Asp Leu Met Lys Arg Ser Asp Glu Tyr 
545                 550                 555                 560 


Glu Arg Leu Ser Lys Arg Lys Leu Glu Met Ala Arg Gln Cys Val Asn 
                565                 570                 575     


Phe Val Val Ala Arg Ala Glu Lys Leu Thr Gln Cys Asn Asn Ile Gly 
            580                 585                 590         


Ile Val Leu Glu Asn Leu Val Val Arg Asn Phe His Gly Ser Gly Arg 
        595                 600                 605             


Arg Glu Ser Gly Trp Glu Gly Phe Phe Glu Pro Lys Arg Glu Asn Arg 
    610                 615                 620                 


Trp Phe Met Gln Val Leu His Lys Ala Phe Ser Asp Leu Ala Gln His 
625                 630                 635                 640 


Arg Gly Val Met Val Phe Glu Val His Pro Ala Tyr Ser Ser Gln Thr 
                645                 650                 655     


Cys Pro Ala Cys Arg Tyr Val Asp Pro Lys Asn Arg Ser Ser Glu Asp 
            660                 665                 670         


Arg Glu Arg Phe Lys Cys Leu Lys Cys Gly Arg Ser Phe Asn Ala Asp 
        675                 680                 685             


Arg Glu Val Ala Thr Phe Asn Ile Arg Glu Ile Ala Arg Thr Gly Val 
    690                 695                 700                 


Gly Leu Pro Lys Pro Asp Cys Glu Arg Ser Arg Gly Val Gln Thr Thr 
705                 710                 715                 720 


Gly Thr Ala Arg Asn Pro Gly Arg Ser Leu Lys Ser Asn Lys Asn Pro 
                725                 730                 735     


Ser Glu Pro Lys His Val Leu Arg Ser Lys Thr Arg Ser Asn Ile Thr 
            740                 745                 750         


Ser Thr Leu Ser Gln Asn Glu Pro Leu Ala Thr Asp Gln Lys Thr Ala 
        755                 760                 765             


Pro Lys Thr Gly Pro 
    770             


<210>  4
<211>  36
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  direct repeat

<400>  4
ccugcaaggg auccaaauug cucuguucgc agagac                                 36


<210>  5
<211>  26
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  direct repeat

<400>  5
auccaaauug cucuguucgc agagac                                            26


<210>  6
<211>  2301
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  parent nuclease nt sequence

<400>  6
atgtctgaga tcacagacct gctgaaggcc aatttcaagg ggaaaacttt taaaagtgcc       60

gatatgagga tggctggccg catcctgaag aaatcagggg cacaggccgt cattaagtac      120

ctgagcgaca aaggagccgt tgacccccct gatttcaggc caccggcaaa gtgcaacatc      180

attgcccaga gtcgcccatt tgatgagtgg cccatctgta aggcttcaat ggcaatccag      240

cagcatatct acggactgac caaaaatgaa ttcgacgaga gctcccctgg caccagcagc      300

gccagccacg agcagtggtt tgctaagacc ggagtcgata cacacggctt cacccatgtt      360

cagggcctga acctgatctt tcagcatgcc aagaaacggt acgagggagt cattaagaaa      420

gttgagaact acaacgaaaa ggagagaaag aaattcgaag gaatcaatga gcggagaagc      480

aaagagggta tgccactgct ggagcctcgg ctgcgtacag ctttcggcga cgatgggaag      540

tttgcagaga aaccaggcgt gaacccgtct atctacctgt atcagcagac aagtccaagg      600

ccgtacgaca agactaaaca cccttatgtg catgccccat tcgaactgaa ggagatcacc      660

acaattccca cccaggacga taggctgaag atcccctttg gagctcctgg tcacgtgcca      720

gagaaacatc gctcacagct gagcatggca aagcacaaaa ggcgccgagc ctggtacgct      780

ctgagccaga acaagcctcg tccacctaag gacggttcca aaggccggcg gagcgtgcgg      840

gacctggcag acctgaaagc agcttctctg gctgatgcaa tcccactggt gagccgggtg      900

ggattcgact gggtggtcat tgatggacga ggtctgctcc gtaacctgag atggaggaag      960

ctcgcccatg aaggcatgac cgtggaggaa atgctgggct tctttagcgg ggaccccgtg     1020

atcgatccaa gaaggaatgt ggccaccttc atctacaagg cagagcacgc cacagtgaag     1080

tcccggaaac caatcggcgg ggctaagcgc gcacgagagg aactgctgaa ggccacagct     1140

tcaagcgacg gcgtgatccg tcaggtcggt ctgattagcg tggacctggg ccagactaac     1200

cccgtcgcct atgaaatctc cagaatgcat caggctaatg gcgagctggt cgcagaacac     1260

ctggagtacg ggctgctgaa cgacgagcaa gtgaatagca ttcagcggta ccgggcagcc     1320

tgggattcaa tgaatgaaag cttccggcag aaggccatcg agtctctgag tatggaagca     1380

caggacgaga ttatgcaggc ctccacaggc gctgcaaaaa gaactaggga agcagtgctg     1440

accatgttcg gtccaaacgc caccctgcct tggtccagaa tgtcctctaa tactacctgc     1500

atctctgacg ccctgattga ggttggaaag gaggaagaga ccaactttgt gacatccaat     1560

ggcccccgca aacgaactga tgctcagtgg gcagcttacc tgcgtccccg ggtgaaccct     1620

gagacccggg ccctgctgaa ccaggccgtc tgggacctga tgaagcgcag cgatgaatat     1680

gagagactgt ccaagaggaa actggagatg gcccggcagt gcgtgaactt cgttgtggca     1740

agagccgaaa aactgacaca gtgtaacaat atcggcattg tgctggagaa cctggtggtg     1800

cggaattttc acggcagtgg gcgccgagaa tcaggatggg agggcttctt cgaacccaag     1860

cgggagaata gatggttcat gcaggtgctg cacaaagctt ttagcgacct ggcacagcat     1920

cgcggcgtga tggtcttcga ggtccaccct gcctacagtt cacagacctg cccagcttgt     1980

cgatatgtgg accccaagaa cagaagctcc gaagatagag agaggttcaa gtgcctgaaa     2040

tgtgggaggt cttttaacgc cgatcgcgaa gttgctactt tcaatatccg cgagattgcc     2100

cgaaccggag tcggtctgcc aaagcctgac cgtgagcgga gccgggacgt gcagacacct     2160

ggaactgctc ggaagtccgg ccggagcctg aagagtcagg acaacccatc agagccgaag     2220

agggtgctgc agagcaaaac ccgcaagaaa atcacatcca ctgaaaccca gaatgagcca     2280

ctggccactg acctgaagac c                                               2301


<210>  7
<211>  2301
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  parent nuclease nt sequence

<400>  7
atgagcgaga tcaccgacct gttgaaggcg aacttcaagg gtaaaacctt taaaagcgcg       60

gatatgcgta tggctggtcg catcctgaag aaaagcggcg cgcaggcggt tatcaagtac      120

ctgtccgaca aaggtgcagt tgacccgccg gatttccgtc cgccggcaaa gtgcaacatc      180

attgctcaga gccgtccgtt tgatgaatgg ccgatttgca aggcgagcat ggctatccag      240

caacatattt atggtctgac caaaaatgag ttcgacgaga gcagcccggg caccagcagc      300

gcaagccacg agcagtggtt tgctaaaacg ggtgttgata cccacggctt cacgcatgtc      360

cagggtctga acttgatctt tcaacatgcg aagaaacgtt acgaaggtgt gatcaagaag      420

gtggagaact acaacgaaaa ggagcgtaag aaattcgaag gtatcaacga gcgtcgcagc      480

aaagaaggca tgccgctgct ggagccgcgt ctgcgtaccg ctttcggtga cgatggcaag      540

tttgcagaaa aaccgggtgt taacccgagc atttacctgt atcagcaaac gagcccgcgt      600

ccgtacgaca agaccaaaca cccgtatgtg catgcgccgt tcgaactgaa ggagatcacc      660

acgattccga cccaggacga tcgtctgaag attccgtttg gtgcgccggg tcatgttccg      720

gagaaacatc gtagccagct gagcatggcg aagcacaaac gtcgccgtgc atggtacgcc      780

ctgagccaaa acaagccgcg tccgccgaag gacggtagca agggtcgccg tagcgtgcgt      840

gacctggcag atttgaaagc agcgagcctg gcagatgcaa tcccgctggt gagccgtgtg      900

ggtttcgact gggtggttat tgatggtcgt ggcctgttgc gcaacctgcg ctggcgtaag      960

ctggcgcatg aaggcatgac cgttgaggaa atgctgggtt tctttagcgg tgacccggtt     1020

atcgatccgc gccgtaatgt ggcgaccttt atttacaaag cggagcacgc taccgtgaag     1080

agccgtaaac cgatcggtgg tgcgaagcgt gcgcgtgagg aactgttgaa agcgaccgcg     1140

agcagcgacg gtgtgatccg tcaggttggc ctgattagcg tggatttggg tcaaaccaac     1200

ccggttgcgt atgaaatcag ccgtatgcat caggcaaatg gcgagctggt tgccgaacac     1260

ctggagtacg gcctgttgaa cgacgaacaa gtgaatagca ttcaacgcta tcgtgcagcc     1320

tgggattcca tgaacgagag cttccgtcaa aaggcgatcg agagcctgag catggaagca     1380

caggacgaga ttatgcaggc gagcaccggt gcagctaaac gtacccgtga ggcagttctg     1440

accatgtttg gtccgaacgc aaccctgccg tggagccgta tgagcagcaa taccacgtgc     1500

atcagcgacg cgctgattga ggtcggtaaa gaggaagaaa ccaactttgt tacgagcaat     1560

ggcccgcgca aacgtaccga tgcacagtgg gcagcatatc tgcgcccgcg tgtgaacccg     1620

gaaacccgtg cgctgttgaa tcaagccgtt tgggacctga tgaagcgttc cgatgaatat     1680

gagcgtctgt ctaagcgcaa gctggagatg gcgcgtcagt gcgttaactt cgtcgtggcg     1740

cgtgcggaaa aactgaccca atgtaacaat atcggtattg tgctggagaa cttggtggtg     1800

cgtaattttc acggtagcgg tcgccgtgaa agcggttggg agggcttctt tgaaccgaag     1860

cgtgagaacc gctggttcat gcaggttctg cacaaagcgt ttagcgacct ggctcaacat     1920

cgtggtgtga tggttttcga ggttcatccg gcatacagca gccagacctg cccggcttgt     1980

cgttatgtgg acccgaagaa ccgtagcagc gaagatcgcg agcgtttcaa gtgcctgaaa     2040

tgtggccgta gctttaacgc agatcgcgaa gtggccacct tcaatatccg tgagattgca     2100

cgtaccggtg ttggcctgcc gaaaccggac cgtgaacgta gccgcgatgt gcaaaccccg     2160

ggcaccgcgc gtaagtccgg tcgtagcctg aaaagccagg acaacccgtc tgagccgaag     2220

cgtgtgctgc aaagcaaaac ccgcaagaaa atcacctcca cggaaaccca aaatgagccg     2280

ctggcgaccg atttgaaaac g                                               2301


<210>  8
<211>  767
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  parent nuclease aa sequence

<400>  8

Met Ser Glu Ile Thr Asp Leu Leu Lys Ala Asn Phe Lys Gly Lys Thr 
1               5                   10                  15      


Phe Lys Ser Ala Asp Met Arg Met Ala Gly Arg Ile Leu Lys Lys Ser 
            20                  25                  30          


Gly Ala Gln Ala Val Ile Lys Tyr Leu Ser Asp Lys Gly Ala Val Asp 
        35                  40                  45              


Pro Pro Asp Phe Arg Pro Pro Ala Lys Cys Asn Ile Ile Ala Gln Ser 
    50                  55                  60                  


Arg Pro Phe Asp Glu Trp Pro Ile Cys Lys Ala Ser Met Ala Ile Gln 
65                  70                  75                  80  


Gln His Ile Tyr Gly Leu Thr Lys Asn Glu Phe Asp Glu Ser Ser Pro 
                85                  90                  95      


Gly Thr Ser Ser Ala Ser His Glu Gln Trp Phe Ala Lys Thr Gly Val 
            100                 105                 110         


Asp Thr His Gly Phe Thr His Val Gln Gly Leu Asn Leu Ile Phe Gln 
        115                 120                 125             


His Ala Lys Lys Arg Tyr Glu Gly Val Ile Lys Lys Val Glu Asn Tyr 
    130                 135                 140                 


Asn Glu Lys Glu Arg Lys Lys Phe Glu Gly Ile Asn Glu Arg Arg Ser 
145                 150                 155                 160 


Lys Glu Gly Met Pro Leu Leu Glu Pro Arg Leu Arg Thr Ala Phe Gly 
                165                 170                 175     


Asp Asp Gly Lys Phe Ala Glu Lys Pro Gly Val Asn Pro Ser Ile Tyr 
            180                 185                 190         


Leu Tyr Gln Gln Thr Ser Pro Arg Pro Tyr Asp Lys Thr Lys His Pro 
        195                 200                 205             


Tyr Val His Ala Pro Phe Glu Leu Lys Glu Ile Thr Thr Ile Pro Thr 
    210                 215                 220                 


Gln Asp Asp Arg Leu Lys Ile Pro Phe Gly Ala Pro Gly His Val Pro 
225                 230                 235                 240 


Glu Lys His Arg Ser Gln Leu Ser Met Ala Lys His Lys Arg Arg Arg 
                245                 250                 255     


Ala Trp Tyr Ala Leu Ser Gln Asn Lys Pro Arg Pro Pro Lys Asp Gly 
            260                 265                 270         


Ser Lys Gly Arg Arg Ser Val Arg Asp Leu Ala Asp Leu Lys Ala Ala 
        275                 280                 285             


Ser Leu Ala Asp Ala Ile Pro Leu Val Ser Arg Val Gly Phe Asp Trp 
    290                 295                 300                 


Val Val Ile Asp Gly Arg Gly Leu Leu Arg Asn Leu Arg Trp Arg Lys 
305                 310                 315                 320 


Leu Ala His Glu Gly Met Thr Val Glu Glu Met Leu Gly Phe Phe Ser 
                325                 330                 335     


Gly Asp Pro Val Ile Asp Pro Arg Arg Asn Val Ala Thr Phe Ile Tyr 
            340                 345                 350         


Lys Ala Glu His Ala Thr Val Lys Ser Arg Lys Pro Ile Gly Gly Ala 
        355                 360                 365             


Lys Arg Ala Arg Glu Glu Leu Leu Lys Ala Thr Ala Ser Ser Asp Gly 
    370                 375                 380                 


Val Ile Arg Gln Val Gly Leu Ile Ser Val Asp Leu Gly Gln Thr Asn 
385                 390                 395                 400 


Pro Val Ala Tyr Glu Ile Ser Arg Met His Gln Ala Asn Gly Glu Leu 
                405                 410                 415     


Val Ala Glu His Leu Glu Tyr Gly Leu Leu Asn Asp Glu Gln Val Asn 
            420                 425                 430         


Ser Ile Gln Arg Tyr Arg Ala Ala Trp Asp Ser Met Asn Glu Ser Phe 
        435                 440                 445             


Arg Gln Lys Ala Ile Glu Ser Leu Ser Met Glu Ala Gln Asp Glu Ile 
    450                 455                 460                 


Met Gln Ala Ser Thr Gly Ala Ala Lys Arg Thr Arg Glu Ala Val Leu 
465                 470                 475                 480 


Thr Met Phe Gly Pro Asn Ala Thr Leu Pro Trp Ser Arg Met Ser Ser 
                485                 490                 495     


Asn Thr Thr Cys Ile Ser Asp Ala Leu Ile Glu Val Gly Lys Glu Glu 
            500                 505                 510         


Glu Thr Asn Phe Val Thr Ser Asn Gly Pro Arg Lys Arg Thr Asp Ala 
        515                 520                 525             


Gln Trp Ala Ala Tyr Leu Arg Pro Arg Val Asn Pro Glu Thr Arg Ala 
    530                 535                 540                 


Leu Leu Asn Gln Ala Val Trp Asp Leu Met Lys Arg Ser Asp Glu Tyr 
545                 550                 555                 560 


Glu Arg Leu Ser Lys Arg Lys Leu Glu Met Ala Arg Gln Cys Val Asn 
                565                 570                 575     


Phe Val Val Ala Arg Ala Glu Lys Leu Thr Gln Cys Asn Asn Ile Gly 
            580                 585                 590         


Ile Val Leu Glu Asn Leu Val Val Arg Asn Phe His Gly Ser Gly Arg 
        595                 600                 605             


Arg Glu Ser Gly Trp Glu Gly Phe Phe Glu Pro Lys Arg Glu Asn Arg 
    610                 615                 620                 


Trp Phe Met Gln Val Leu His Lys Ala Phe Ser Asp Leu Ala Gln His 
625                 630                 635                 640 


Arg Gly Val Met Val Phe Glu Val His Pro Ala Tyr Ser Ser Gln Thr 
                645                 650                 655     


Cys Pro Ala Cys Arg Tyr Val Asp Pro Lys Asn Arg Ser Ser Glu Asp 
            660                 665                 670         


Arg Glu Arg Phe Lys Cys Leu Lys Cys Gly Arg Ser Phe Asn Ala Asp 
        675                 680                 685             


Arg Glu Val Ala Thr Phe Asn Ile Arg Glu Ile Ala Arg Thr Gly Val 
    690                 695                 700                 


Gly Leu Pro Lys Pro Asp Arg Glu Arg Ser Arg Asp Val Gln Thr Pro 
705                 710                 715                 720 


Gly Thr Ala Arg Lys Ser Gly Arg Ser Leu Lys Ser Gln Asp Asn Pro 
                725                 730                 735     


Ser Glu Pro Lys Arg Val Leu Gln Ser Lys Thr Arg Lys Lys Ile Thr 
            740                 745                 750         


Ser Thr Glu Thr Gln Asn Glu Pro Leu Ala Thr Asp Leu Lys Thr 
        755                 760                 765         


<210>  9
<211>  36
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  direct repeat

<400>  9
ccaucaaugg auccaaauug cucuguacgc agagac                                 36


<210>  10
<211>  26
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  direct repeat

<400>  10
auccaaauug cucuguacgc agagac                                            26


<210>  11
<211>  2256
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  parent nuclease nt sequence

<400>  11
atgcgcatgg ctggtcgtat cctgaagaag agcggcgcgc aggcggttat caagtacctg       60

agcgacaaag gtgcagttga cccgccggat ttccgtccgc cggcaaagtg caacatcatt      120

gctcaaagcc gtccgtttga tgaatggccg atttgtaagg cgagcatggc tatccagcaa      180

catatttatg gtctgaccaa aaatgagttc gatgagagca gcccgggcac cagcagcgca      240

agccacgagc agtggtttgc caaaaccggt gttgatacgc acggcttcac ccatgtccag      300

ggtctgaact tgatctttca acatgcgaag aaacgttacg aaggtgtgat caagaaggtg      360

gagaactaca acgaaaagga gcgtaagaaa ttcgaaggta tcaacgagcg tcgcagcaaa      420

gaaggcatgc cgctgctgga gccgcgtctg cgtaccgcgt tcggtgacga tggcaagttt      480

gctgaaaaac cgggtgttaa cccgtccatt tacctgtatc agcaaacgag cccgcgtccg      540

tacgacaaga ccaaacaccc gtatgtgcat gcgccgttcg aactgaagga gatcaccacg      600

attccgaccc aggacgatcg tctgaagatt ccgtttggtg cgccgggtca tgttccggag      660

aaacatcgta gccagctgag catggcgaag cacaaacgtc gccgtgcatg gtacgccctg      720

agccaaaaca agccgcgtcc gccgaaggac ggtagcaagg gtcgccgtag cgtgcgtgac      780

ctggcagatt tgaaagcagc gagcctggca gatgcaatcc cgctggtgag ccgtgtgggt      840

ttcgactggg tggttattga tggtcgcggc ctgttgcgta acctgcgctg gcgtaagctg      900

gcgcatgaag gcatgaccgt tgaggaaatg ctgggtttct ttagcggtga cccggttatc      960

gatccgcgcc gtaatgtggc gacctttatt tacaaagcgg agcacgctac cgtgaagagc     1020

cgtaaaccga tcggtggtgc gaagcgtgcg cgtgaggaac tgttgaaagc gaccgcgagc     1080

agcgacggtg tgatccgtca ggttggcctg attagcgtgg atttgggtca aaccaacccg     1140

gttgcgtatg aaatcagccg tatgcatcag gcaaatggcg agctggttgc cgaacacctg     1200

gagtacggcc tgttgaacga cgagcaagtg aatagcattc aacgctatcg tgcagcctgg     1260

gatagcatga acgagagctt ccgtcaaaag gcgatcgaga gcctgtccat ggaagctcag     1320

gatgagatta tgcaggcgag caccggtgca gctaaacgta cccgtgaggc agttctgacc     1380

atgtttggtc cgaacgcaac cctgccgtgg agccgtatga gcagcaatac cacgtgcatc     1440

agcgacgcgc tgattgaggt cggtaaagag gaagaaacca actttgttac cagcaatggc     1500

ccgcgcaaac gtaccgatgc acagtgggca gcatatctgc gcccgcgtgt gaacccggaa     1560

acccgtgcgc tgttgaatca agccgtttgg gacctgatga agcgttctga tgaatatgag     1620

cgcctgagca agcgtaagct ggagatggcg cgccagtgcg ttaacttcgt cgtggcgcgt     1680

gcggaaaaac tgacccaatg taacaatatc ggtattgtgc tggagaactt ggtggtgcgt     1740

aattttcacg gtagcggtcg ccgtgaatcc ggttgggagg gcttctttga accgaagcgc     1800

gagaaccgtt ggttcatgca ggttctgcac aaagcgttta gcgacctggc tcaacatcgt     1860

ggtgtgatgg ttttcgaagt tcatccggca tacagcagcc agacctgccc ggcttgtcgc     1920

tatgtggacc cgaaaaaccg tagcagcgaa gatcgcgagc gtttcaagtg cctgaaatgt     1980

ggccgcagct ttaacgcaga tcgtgaagtg gccaccttca atatccgcga gattgcacgt     2040

accggtgtgg gcctgccgaa gccggactgc gagcgcagcc gtgatgtgca aaccccgggc     2100

accgcacgta aatccggtcg tagcctgaag agcaacaaaa atccgagcga accgaagcac     2160

gtgctgcgct ctaaaacccg tagcaacatc acctccacgc tgtctcagaa tgagccgttg     2220

gcgacggacc aaaagaccgc tccgaaaacg ggtccg                               2256


<210>  12
<211>  2259
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  parent nuclease nt sequence

<400>  12
atatgagaat ggctggcagg atcctgaaga aaagcggggc acaggccgtc attaagtacc       60

tgtccgacaa aggagccgtt gacccccctg atttcagacc accggcaaag tgcaacatca      120

ttgcccagtc aaggcctttt gatgagtggc caatctgtaa ggctagcatg gcaatccagc      180

agcatatcta cggactgacc aaaaatgaat tcgacgagag ctccccaggc accagcagcg      240

ccagccacga gcagtggttt gccaagactg gagtcgatac ccacggcttc acccatgttc      300

agggcctgaa cctgatcttt cagcatgcca agaaacgcta cgaaggagtc attaagaaag      360

ttgagaacta caacgaaaag gagcggaaga aatttgaagg aatcaatgag cggagaagca      420

aagagggtat gccactgctg gagcctcggc tgcgtacagc cttcggcgac gatgggaagt      480

ttgctgagaa accaggcgtg aacccgtcca tctacctgta tcagcagaca tctccacggc      540

cgtacgacaa gactaaacac ccctatgtgc atgccccttt cgaactgaag gagatcacca      600

caattcccac ccaggacgat agactgaaga tcccctttgg agcccctggt cacgtgccag      660

agaaacatag gtcacagctg agcatggcta agcacaaaag gcgccgagcc tggtacgctc      720

tgtcccagaa caagccacgt ccacctaagg acggtagcaa aggccggcgg agcgtgcggg      780

acctggcaga cctgaaagca gctagtctgg ctgatgcaat ccctctggtg agccgggtgg      840

gattcgactg ggtggtcatt gatggacgcg gtctgctccg aaacctgaga tggaggaagc      900

tcgcccatga aggcatgacc gtggaggaaa tgctgggctt ctttagtggg gaccccgtga      960

tcgatcccag aaggaatgtg gccaccttca tctacaaggc agagcacgcc acagtgaaga     1020

gccggaaacc tatcggcggg gctaagcgcg cacgagagga actgctgaag gccacagctt     1080

caagcgacgg cgtgatccgt caggtcggtc tgatttccgt ggacctgggc cagactaacc     1140

cagtcgccta tgaaatctct cggatgcatc aggctaatgg cgagctggtc gcagaacacc     1200

tggagtacgg gctgctgaac gacgagcaag tgaattccat tcagcggtac cgggcagcct     1260

gggattccat gaatgaatct ttccgccaga aggccatcga gtctctgagt atggaagctc     1320

aggatgagat tatgcaggca tctacaggcg ctgcaaaaag aactagggaa gctgtgctga     1380

ccatgttcgg tccaaacgcc accctgccat ggtctcggat gtcctctaat actacctgca     1440

tcagtgacgc cctgattgag gttggaaagg aggaagagac taactttgtg accagcaatg     1500

gccctcgcaa acgaactgat gctcagtggg ccgcttacct gcgtcctcgg gtgaacccag     1560

agacccgggc cctgctgaac caggccgtct gggacctgat gaagaggtca gacgagtatg     1620

agcggctgag caagagaaaa ctggagatgg cccgccagtg cgtgaacttc gttgtggcac     1680

gggccgaaaa gctgacacag tgtaacaata tcggcattgt gctggagaac ctggtggtgc     1740

ggaattttca cggctctggg cgccgagaaa gtggatggga gggcttcttc gaaccaaagc     1800

gtgagaatcg gtggttcatg caggtgctgc acaaagcttt tagcgacctg gcacagcata     1860

ggggcgtgat ggtcttcgag gtccaccccg catacagttc acagacctgc cctgcctgta     1920

gatatgtgga cccaaagaac aggagctccg aagatagaga gaggttcaag tgcctgaaat     1980

gtgggcgctc ctttaacgcc gatcgagaag ttgctacttt caatatcagg gagattgcac     2040

gcaccggagt cggtctgccc aagcctgact gtgagcggag ccgggacgtg cagaccccag     2100

gaacagctcg aaaatccggc cggagcctga agagtaacaa aaatccatct gaaccgaagc     2160

acgtgctgag aagtaaaacc aggtcaaaca tcacatcaac tctgagccag aatgagcctc     2220

tcgccacaga ccagaagact gctccgaaaa ccggcccca                            2259


<210>  13
<211>  773
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  parent nuclease aa sequence

<400>  13

Met Ser Glu Ile Thr Asp Leu Leu Lys Ala Asn Phe Lys Gly Lys Thr 
1               5                   10                  15      


Phe Lys Ser Ala Asp Met Arg Met Ala Gly Arg Ile Leu Lys Lys Ser 
            20                  25                  30          


Gly Ala Gln Ala Val Ile Lys Tyr Leu Ser Asp Lys Gly Ala Val Asp 
        35                  40                  45              


Pro Pro Asp Phe Arg Pro Pro Ala Lys Cys Asn Ile Ile Ala Gln Ser 
    50                  55                  60                  


Arg Pro Phe Asp Glu Trp Pro Ile Cys Lys Ala Ser Met Ala Ile Gln 
65                  70                  75                  80  


Gln His Ile Tyr Gly Leu Thr Lys Asn Glu Phe Asp Glu Ser Ser Pro 
                85                  90                  95      


Gly Thr Ser Ser Ala Ser His Glu Gln Trp Phe Ala Lys Thr Gly Val 
            100                 105                 110         


Asp Thr His Gly Phe Thr His Val Gln Gly Leu Asn Leu Ile Phe Gln 
        115                 120                 125             


His Ala Lys Lys Arg Tyr Glu Gly Val Ile Lys Lys Val Glu Asn Tyr 
    130                 135                 140                 


Asn Glu Lys Glu Arg Lys Lys Phe Glu Gly Ile Asn Glu Arg Arg Ser 
145                 150                 155                 160 


Lys Glu Gly Met Pro Leu Leu Glu Pro Arg Leu Arg Thr Ala Phe Gly 
                165                 170                 175     


Asp Asp Gly Lys Phe Ala Glu Lys Pro Gly Val Asn Pro Ser Ile Tyr 
            180                 185                 190         


Leu Tyr Gln Gln Thr Ser Pro Arg Pro Tyr Asp Lys Thr Lys His Pro 
        195                 200                 205             


Tyr Val His Ala Pro Phe Glu Leu Lys Glu Ile Thr Thr Ile Pro Thr 
    210                 215                 220                 


Gln Asp Asp Arg Leu Lys Ile Pro Phe Gly Ala Pro Gly His Val Pro 
225                 230                 235                 240 


Glu Lys His Arg Ser Gln Leu Ser Met Ala Lys His Lys Arg Arg Arg 
                245                 250                 255     


Ala Trp Tyr Ala Leu Ser Gln Asn Lys Pro Arg Pro Pro Lys Asp Gly 
            260                 265                 270         


Ser Lys Gly Arg Arg Ser Val Arg Asp Leu Ala Asp Leu Lys Ala Ala 
        275                 280                 285             


Ser Leu Ala Asp Ala Ile Pro Leu Val Ser Arg Val Gly Phe Asp Trp 
    290                 295                 300                 


Val Val Ile Asp Gly Arg Gly Leu Leu Arg Asn Leu Arg Trp Arg Lys 
305                 310                 315                 320 


Leu Ala His Glu Gly Met Thr Val Glu Glu Met Leu Gly Phe Phe Ser 
                325                 330                 335     


Gly Asp Pro Val Ile Asp Pro Arg Arg Asn Val Ala Thr Phe Ile Tyr 
            340                 345                 350         


Lys Ala Glu His Ala Thr Val Lys Ser Arg Lys Pro Ile Gly Gly Ala 
        355                 360                 365             


Lys Arg Ala Arg Glu Glu Leu Leu Lys Ala Thr Ala Ser Ser Asp Gly 
    370                 375                 380                 


Val Ile Arg Gln Val Gly Leu Ile Ser Val Asp Leu Gly Gln Thr Asn 
385                 390                 395                 400 


Pro Val Ala Tyr Glu Ile Ser Arg Met His Gln Ala Asn Gly Glu Leu 
                405                 410                 415     


Val Ala Glu His Leu Glu Tyr Gly Leu Leu Asn Asp Glu Gln Val Asn 
            420                 425                 430         


Ser Ile Gln Arg Tyr Arg Ala Ala Trp Asp Ser Met Asn Glu Ser Phe 
        435                 440                 445             


Arg Gln Lys Ala Ile Glu Ser Leu Ser Met Glu Ala Gln Asp Glu Ile 
    450                 455                 460                 


Met Gln Ala Ser Thr Gly Ala Ala Lys Arg Thr Arg Glu Ala Val Leu 
465                 470                 475                 480 


Thr Met Phe Gly Pro Asn Ala Thr Leu Pro Trp Ser Arg Met Ser Ser 
                485                 490                 495     


Asn Thr Thr Cys Ile Ser Asp Ala Leu Ile Glu Val Gly Lys Glu Glu 
            500                 505                 510         


Glu Thr Asn Phe Val Thr Ser Asn Gly Pro Arg Lys Arg Thr Asp Ala 
        515                 520                 525             


Gln Trp Ala Ala Tyr Leu Arg Pro Arg Val Asn Pro Glu Thr Arg Ala 
    530                 535                 540                 


Leu Leu Asn Gln Ala Val Trp Asp Leu Met Lys Arg Ser Asp Glu Tyr 
545                 550                 555                 560 


Glu Arg Leu Ser Lys Arg Lys Leu Glu Met Ala Arg Gln Cys Val Asn 
                565                 570                 575     


Phe Val Val Ala Arg Ala Glu Lys Leu Thr Gln Cys Asn Asn Ile Gly 
            580                 585                 590         


Ile Val Leu Glu Asn Leu Val Val Arg Asn Phe His Gly Ser Gly Arg 
        595                 600                 605             


Arg Glu Ser Gly Trp Glu Gly Phe Phe Glu Pro Lys Arg Glu Asn Arg 
    610                 615                 620                 


Trp Phe Met Gln Val Leu His Lys Ala Phe Ser Asp Leu Ala Gln His 
625                 630                 635                 640 


Arg Gly Val Met Val Phe Glu Val His Pro Ala Tyr Ser Ser Gln Thr 
                645                 650                 655     


Cys Pro Ala Cys Arg Tyr Val Asp Pro Lys Asn Arg Ser Ser Glu Asp 
            660                 665                 670         


Arg Glu Arg Phe Lys Cys Leu Lys Cys Gly Arg Ser Phe Asn Ala Asp 
        675                 680                 685             


Arg Glu Val Ala Thr Phe Asn Ile Arg Glu Ile Ala Arg Thr Gly Val 
    690                 695                 700                 


Gly Leu Pro Lys Pro Asp Cys Glu Arg Ser Arg Asp Val Gln Thr Pro 
705                 710                 715                 720 


Gly Thr Ala Arg Lys Ser Gly Arg Ser Leu Lys Ser Asn Lys Asn Pro 
                725                 730                 735     


Ser Glu Pro Lys His Val Leu Arg Ser Lys Thr Arg Ser Asn Ile Thr 
            740                 745                 750         


Ser Thr Leu Ser Gln Asn Glu Pro Leu Ala Thr Asp Gln Lys Thr Ala 
        755                 760                 765             


Pro Lys Thr Gly Pro 
    770             


<210>  14
<211>  25
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  direct repeat

<400>  14
uccaaauugc ucuguucgca gagac                                             25


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  15

Gly Gly Gly Gly Ser 
1               5   


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  16

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  18

Gly Ser Ser Gly 
1               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  19

Gly Ser Ser Gly Gly Ser Ser Gly 
1               5               


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  20

Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
1               5                   10          


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  21

Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
1               5                   10                  15      


<210>  22
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  22

Gly Ser Gly 
1           


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  23

Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10          


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  24

Gly Gly Gly Ser 
1               


