                         SEQUENCE LISTING

<110>  Transgene
 
<120>  Vectorization of MUC1 T cell engager

<130>  AE3564 PCT S3

<140>
<141>  2022-01-04

<150>  EP 21 305 010.7
<151>  2021-01-05

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Short peptide linker L3

<400>  1

Gly Gly Gly Gly Ser 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Example of short peptide linker

<400>  2

Gly Ser Gly Ser Gly 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Example 3 of a suitable short peptide linker

<400>  3

Ser Gly Ser Gly Ser 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Example 4 of a suitable short peptide linker

<400>  4

Gly Ser Thr Ser Gly 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Example 5 of a suitable short peptide linker

<400>  5

Ser Gly Thr Gly Ser 
1               5   


<210>  6
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Example of a suitable long peptide linker (illustrated as L1)

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Example 2 of a suitable long peptide liker (illustrated as L2)

<400>  7

Gly Gly Ser Gly Thr Ser Gly Thr Ser Gly Thr Ser Gly Gly Ser 
1               5                   10                  15  


<210>  8
<211>  58
<212>  PRT
<213>  artificial sequence

<220>
<223>  hinge sequence of an immunoglobulin IgD

<400>  8

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  9
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  dimerization domain of a CH3 part of an IgG1 immunoglobulin

<400>  9

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  10
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  10

Met Gly Leu Gly Leu Gln Trp Val Phe Phe Val Ala Leu Leu Lys Gly 
1               5                   10                  15      


Val His Cys 
            


<210>  11
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  example 1 of a suitable tag

<400>  11

His His His His His His Asp Tyr Lys Asp Asp Asp Asp Lys Leu Val 
1               5                   10                  15      


Pro Arg Gly Ser 
            20  


<210>  12
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Example 2 of a suitable tag

<400>  12

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  13
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Example 3 of a suitable tag

<400>  13

Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
1               5                   10                  15      


<210>  14
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain CDR1 of OKT3 antibody

<400>  14

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  15
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain CDR2 of OKT3 antibody

<400>  15

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  16
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain CDR3 of OKT3 antibody

<400>  16

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain CDR1 of OKT3 antibody

<400>  17

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  18
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain CDR2 of OKT3 antibody

<400>  18

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  19
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain CDR3 of OKT3 antibody

<400>  19

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  20
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain variable region VH of OKT3 antibody

<400>  20

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  21
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain variable region VL of OKT3 antibody

<400>  21

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            100                 105     


<210>  22
<211>  240
<212>  PRT
<213>  artificial sequence

<220>
<223>  OKT3 antibody (scFv)

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
225                 230                 235                 240 


<210>  23
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain CDR1 a MUC1 antibody

<400>  23

Gly Phe Thr Phe Ser Asn Tyr Trp 
1               5               


<210>  24
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain CDR2 of aMUC1 antibody

<400>  24

Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  25
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain CDR3 of aMUC1 antibody SM3

<400>  25

Thr Gly Val Gly Gln Phe Ala Tyr 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain CDR3 of aMUC1 antibody HMFG2

<400>  26

Thr Phe Gly Asn Ser Phe Ala Tyr 
1               5               


<210>  27
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain CDR1 of a MUC1 antibody

<400>  27

Thr Gly Ala Val Thr Thr Ser Asn Tyr 
1               5                   


<210>  28
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain CDR2 of aMUC1 antibody


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Gly Thr Asn Xaa 
1               


<210>  29
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain CDR3 of aMUC1 antibody

<400>  29

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  30
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain variable region VH of the aMUC1 SM3 antibody

<400>  30

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Val Gly Gln Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  31
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain variable region VH of aMUC1 HMFG2 antibody

<400>  31

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  32
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain variable region (VL) of aMUC1 antibody (SM3 or HMFG2)

<400>  32

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  33
<211>  241
<212>  PRT
<213>  artificial sequence

<220>
<223>  aMUC1 antibody (scFv of HMFG2 antibody)

<400>  33

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr 
    130                 135                 140                 


Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 
145                 150                 155                 160 


Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His 
                165                 170                 175     


Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu 
    210                 215                 220                 


Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
225                 230                 235                 240 


Leu 
    


<210>  34
<211>  496
<212>  PRT
<213>  artificial sequence

<220>
<223>  Amino acid sequence of the HMFG2-OKT3 tandem scFV expresssed by 
       pTG19274

<400>  34

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr 
    130                 135                 140                 


Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 
145                 150                 155                 160 


Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His 
                165                 170                 175     


Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu 
    210                 215                 220                 


Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
225                 230                 235                 240 


Leu Gly Gly Ser Gly Thr Ser Gly Thr Ser Gly Thr Ser Gly Gly Ser 
                245                 250                 255     


Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
        275                 280                 285             


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
305                 310                 315                 320 


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
                325                 330                 335     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
385                 390                 395                 400 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
                405                 410                 415     


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
            420                 425                 430         


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
        435                 440                 445             


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    450                 455                 460                 


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
465                 470                 475                 480 


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
                485                 490                 495     


<210>  35
<211>  515
<212>  PRT
<213>  artificial sequence

<220>
<223>  HMFG2-OKT3 scFV with signal peptide expressed from pTG19274

<400>  35

Met Gly Leu Gly Leu Gln Trp Val Phe Phe Val Ala Leu Leu Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala 
145                 150                 155                 160 


Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser 
                165                 170                 175     


Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys 
            180                 185                 190         


Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala 
        195                 200                 205             


Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala 
    210                 215                 220                 


Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe 
225                 230                 235                 240 


Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Thr Val Leu Gly Gly Ser Gly Thr Ser Gly Thr Ser Gly Thr Ser 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
            340                 345                 350         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser 
                405                 410                 415     


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
            420                 425                 430         


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
        435                 440                 445             


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
    450                 455                 460                 


Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
465                 470                 475                 480 


Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
                485                 490                 495     


Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
            500                 505                 510         


Glu Ile Asn 
        515 


<210>  36
<211>  531
<212>  PRT
<213>  artificial sequence

<220>
<223>  HMFG2-OKT3 tandem scFV with peptide signal (SP) and tags 
       expressed from pTG19274

<400>  36

Met Gly Leu Gly Leu Gln Trp Val Phe Phe Val Ala Leu Leu Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala 
145                 150                 155                 160 


Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser 
                165                 170                 175     


Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys 
            180                 185                 190         


Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala 
        195                 200                 205             


Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala 
    210                 215                 220                 


Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe 
225                 230                 235                 240 


Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Thr Val Leu Gly Gly Ser Gly Thr Ser Gly Thr Ser Gly Thr Ser 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
        275                 280                 285             


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    290                 295                 300                 


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
305                 310                 315                 320 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                325                 330                 335     


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
            340                 345                 350         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
        355                 360                 365             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser 
                405                 410                 415     


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
            420                 425                 430         


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
        435                 440                 445             


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
    450                 455                 460                 


Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
465                 470                 475                 480 


Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
                485                 490                 495     


Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
            500                 505                 510         


Glu Ile Asn Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys His His His 
        515                 520                 525             


His His His 
    530     


<210>  37
<211>  651
<212>  PRT
<213>  artificial sequence

<220>
<223>  HMFG2-OKT3 dimeric tandem scFV expressed from pTG19280

<400>  37

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr 
    130                 135                 140                 


Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 
145                 150                 155                 160 


Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His 
                165                 170                 175     


Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu 
    210                 215                 220                 


Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
225                 230                 235                 240 


Leu Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro 
                245                 250                 255     


Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr 
            260                 265                 270         


Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys 
        275                 280                 285             


Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
                405                 410                 415     


Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser 
            420                 425                 430         


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val 
        435                 440                 445             


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro 
    450                 455                 460                 


Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr 
465                 470                 475                 480 


Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
                485                 490                 495     


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp 
            500                 505                 510         


Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
        515                 520                 525             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
545                 550                 555                 560 


Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
                565                 570                 575     


Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile 
            580                 585                 590         


Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly 
        595                 600                 605             


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala 
    610                 615                 620                 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe 
625                 630                 635                 640 


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
                645                 650     


<210>  38
<211>  670
<212>  PRT
<213>  artificial sequence

<220>
<223>  HMFG2-OKT3 dimeric tandem scFV with signal peptide expressed from
       pTG19280

<400>  38

Met Gly Leu Gly Leu Gln Trp Val Phe Phe Val Ala Leu Leu Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala 
145                 150                 155                 160 


Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser 
                165                 170                 175     


Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys 
            180                 185                 190         


Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala 
        195                 200                 205             


Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala 
    210                 215                 220                 


Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe 
225                 230                 235                 240 


Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Thr Val Leu Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr 
            260                 265                 270         


Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro 
        275                 280                 285             


Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu 
    290                 295                 300                 


Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gln Val 
            420                 425                 430         


Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val 
        435                 440                 445             


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met 
    450                 455                 460                 


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
465                 470                 475                 480 


Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
                485                 490                 495     


Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
            500                 505                 510         


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
        515                 520                 525             


Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
    530                 535                 540                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser 
                565                 570                 575     


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
            580                 585                 590         


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys 
        595                 600                 605             


Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His 
    610                 615                 620                 


Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
                645                 650                 655     


Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            660                 665                 670 


<210>  39
<211>  686
<212>  PRT
<213>  artificial sequence

<220>
<223>  HMFG2-OKT3 dimeric tandem scFV with signal peptide (SP) and tags 
       expressed from pTG19280

<400>  39

Met Gly Leu Gly Leu Gln Trp Val Phe Phe Val Ala Leu Leu Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala 
145                 150                 155                 160 


Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser 
                165                 170                 175     


Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys 
            180                 185                 190         


Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala 
        195                 200                 205             


Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala 
    210                 215                 220                 


Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe 
225                 230                 235                 240 


Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Thr Val Leu Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr 
            260                 265                 270         


Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro 
        275                 280                 285             


Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu 
    290                 295                 300                 


Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gln Val 
            420                 425                 430         


Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val 
        435                 440                 445             


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met 
    450                 455                 460                 


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
465                 470                 475                 480 


Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
                485                 490                 495     


Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
            500                 505                 510         


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
        515                 520                 525             


Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
    530                 535                 540                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser 
                565                 570                 575     


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
            580                 585                 590         


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys 
        595                 600                 605             


Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His 
    610                 615                 620                 


Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
                645                 650                 655     


Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Ser 
            660                 665                 670         


Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
        675                 680                 685     


<210>  40
<211>  476
<212>  PRT
<213>  artificial sequence

<220>
<223>  hscDb3-MUC1 diabody expressed from pTG19277

<400>  40

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln 
        115                 120                 125             


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
    130                 135                 140                 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
145                 150                 155                 160 


Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
                165                 170                 175     


Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr 
            180                 185                 190         


Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
        195                 200                 205             


Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys 
    210                 215                 220                 


Leu Glu Ile Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
                245                 250                 255     


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            260                 265                 270         


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
        275                 280                 285             


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
    290                 295                 300                 


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
305                 310                 315                 320 


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
                325                 330                 335     


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
            340                 345                 350         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gln 
        355                 360                 365             


Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr 
    370                 375                 380                 


Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn 
385                 390                 395                 400 


Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu 
                405                 410                 415     


Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe Ser 
            420                 425                 430         


Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln 
        435                 440                 445             


Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His 
    450                 455                 460                 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
465                 470                 475     


<210>  41
<211>  495
<212>  PRT
<213>  artificial sequence

<220>
<223>  hscDb3-MUC1 diabody with signal peptide (SP) expressed from 
       pTG19277

<400>  41

Met Gly Leu Gly Leu Gln Trp Val Phe Phe Val Ala Leu Leu Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            260                 265                 270         


Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        275                 280                 285             


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly 
    290                 295                 300                 


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
305                 310                 315                 320 


Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys 
                325                 330                 335     


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            340                 345                 350         


Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu 
        355                 360                 365             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro 
385                 390                 395                 400 


Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr 
                405                 410                 415     


Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe 
            420                 425                 430         


Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala 
        435                 440                 445             


Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr 
    450                 455                 460                 


Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr 
465                 470                 475                 480 


Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                485                 490                 495 


<210>  42
<211>  511
<212>  PRT
<213>  artificial sequence

<220>
<223>  hscDb3-MUC1 diabody with SP and tags expressed from pTG19277

<400>  42

Met Gly Leu Gly Leu Gln Trp Val Phe Phe Val Ala Leu Leu Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val 
145                 150                 155                 160 


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            260                 265                 270         


Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        275                 280                 285             


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly 
    290                 295                 300                 


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
305                 310                 315                 320 


Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys 
                325                 330                 335     


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            340                 345                 350         


Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu 
        355                 360                 365             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro 
385                 390                 395                 400 


Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr 
                405                 410                 415     


Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe 
            420                 425                 430         


Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala 
        435                 440                 445             


Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr 
    450                 455                 460                 


Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr 
465                 470                 475                 480 


Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                485                 490                 495     


Ser Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
            500                 505                 510     


<210>  43
<211>  1596
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nucleotide sequence encoding the HMFG2-OKT3 tandem scFv wit 
       signal peptide and tags expressed from pTG19274

<400>  43
atgggactgg gactgcaatg ggtgttcttc gtggccctgc tgaaaggcgt gcactgcgaa       60

gtgaagctgg aagagtctgg cggaggactg gttcagcctg gcggatctat gaagctgagc      120

tgtgtggcca gcggcttcac cttcagcaac tactggatga actgggtccg acagagcccc      180

gagaaaggcc tggaatgggt tgccgagatc cggctgaagt ccaacaacta cgccacacac      240

tacgccgaga gcgtgaaggg cagattcacc atcagccggg acgacagcaa gagcagcgtg      300

tacctccaga tgaacaacct gagagccgag gacaccggca tctactactg caccttcggc      360

aacagcttcg cctattgggg ccagggcaca accgtgacag tttctagcgg aggcggtgga      420

tccggcggcg ggggatctgg tggcggaggt tctcaagctg tggtcacaca agagagcgcc      480

ctgacaacaa gccctggcga gacagtgacc ctgacctgta gatcttctac aggcgccgtg      540

accaccagca attacgccaa ctgggtgcaa gagaagcccg accacctgtt cacaggactg      600

atcggcggca ccaacaatag agcacctggc gtgccagcca gattcagcgg ctctctgatc      660

ggagataagg ccgcactgac aatcacaggc gcccagacag aggacgaggc catctatttc      720

tgcgccctgt ggtacagcaa ccactgggtt ttcggcggag gcaccaagct gacagtgctc      780

ggaggatctg gcaccagcgg cacatctggt acatcaggcg gatctcaggt gcagctccag      840

cagtctggtg ccgaacttgc tagacctggc gcctccgtga agatgagctg caaggcctct      900

ggctacacct tcaccagata caccatgcac tgggtcaagc agaggcctgg acagggactc      960

gagtggatcg gctacatcaa ccccagcaga ggctacacca actacaacca gaagttcaag     1020

gacaaggcca ctctgaccac cgacaagtct agcagcaccg cctacatgca gctgagcagc     1080

ctgacaagcg aggacagcgc cgtgtactac tgtgcccggt actacgacga ccactactgc     1140

ctggattact ggggacaggg aaccacactg accgtgtcat ctggcggtgg gggaagcggt     1200

ggaggcggaa gcgggggtgg tggatctcaa attgtgctga cacagagccc tgccatcatg     1260

agcgctagcc caggcgaaaa agtgacaatg acctgctccg ccagcagctc cgtgtcctac     1320

atgaactggt atcagcagaa gtccggcaca agccccaaga gatggatcta cgacaccagc     1380

aaactggcct caggcgtgcc cgctcacttt agaggttctg gctctggcac ctcctacagc     1440

ctgaccatct ctggcatgga agccgaagat gccgccacct actactgtca gcagtggtcc     1500

agcaatccct tcacctttgg cagcgggacc aagctggaaa tcaacggcag cgactacaag     1560

gacgacgacg acaagcacca ccaccatcac cactga                               1596


<210>  44
<211>  1536
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nucleotide sequence encoding the hscDb3-MUC1 diabody with SP and 
       tags carried by pTG19277

<400>  44
atgggactgg gactgcaatg ggtgttcttc gtggccctgc tgaaaggcgt gcactgcgaa       60

gtgaagctgg aagagtctgg cggaggactg gttcagcctg gcggatctat gaagctgagc      120

tgtgtggcca gcggcttcac cttcagcaac tactggatga actgggtccg acagagcccc      180

gagaaaggcc tggaatgggt tgccgagatc cggctgaagt ccaacaacta cgccacacac      240

tacgccgaga gcgtgaaggg cagattcacc atcagccggg acgacagcaa gagcagcgtg      300

tacctccaga tgaacaacct gagagccgag gacaccggca tctactactg caccttcggc      360

aacagcttcg cctattgggg ccagggcaca accgtgacag tttctagtgg cggcggaggc      420

tctcagatcg tgctgacaca gagccctgcc atcatgtctg ctagccctgg cgagaaagtg      480

accatgacct gtagcgccag cagctccgtg tcctacatga actggtatca gcagaagtcc      540

ggcacaagcc ccaagcggtg gatctacgat acaagcaagc tggcctctgg cgtgcccgct      600

cactttagag gatctggcag cggcaccagc tacagcctga caatctctgg catggaagcc      660

gaggatgccg ccacctacta ttgccagcag tggtccagca atcccttcac atttggctcc      720

ggcaccaagc tggaaatcaa cggcggtggg ggaagcggtg gaggcggaag cgggggtggt      780

ggatctcaag ttcagctgca acagagcgga gccgagcttg ctagaccagg cgcctctgtg      840

aagatgagct gcaaggcctc cggctacaca ttcacccggt acaccatgca ctgggtcaag      900

cagaggcctg gacagggact cgagtggatc ggctacatca accccagcag aggctacacc      960

aactacaacc agaagttcaa ggacaaggcc acactgacca ccgacaagtc tagcagcacc     1020

gcctacatgc agctgagcag cctgacctct gaggacagcg ccgtgtacta ctgtgcccgg     1080

tactacgacg accactactg cctggattac tggggacagg gaaccactct gaccgtgtct     1140

agcggaggcg gaggatcaca ggccgtggtc acacaagaga gcgccctgac aacaagccca     1200

ggcgagactg tgacactgac atgcagatct agcacaggcg ccgtgaccac cagcaattac     1260

gccaactggg tgcaagagaa gcccgaccac ctgttcacag gactgatcgg cggcaccaac     1320

aatagagcac ctggggtgcc agccagattc agcggctctc tgatcggaga taaggccgct     1380

ctgacaatca ccggcgctca gacagaggac gaggccatct atttctgcgc cctgtggtac     1440

agcaaccact gggttttcgg aggcggcaca aagctgacag tgctgggcag cgactacaag     1500

gacgacgacg acaagcacca ccaccatcac cactga                               1536


<210>  45
<211>  2061
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nucleotide sequence encoding the HMFG2-OKT3 antibody with signal 
       peptide (SP) and tags carried by pTG19280

<400>  45
atgggactgg gactgcaatg ggtgttcttc gtggccctgc tgaaaggcgt gcactgcgaa       60

gtgaagctgg aagagtctgg cggaggactg gttcagcctg gcggatctat gaagctgagc      120

tgtgtggcca gcggcttcac cttcagcaac tactggatga actgggtccg acagagcccc      180

gagaaaggcc tggaatgggt tgccgagatc cggctgaagt ccaacaacta cgccacacac      240

tacgccgaga gcgtgaaggg cagattcacc atcagccggg acgacagcaa gagcagcgtg      300

tacctccaga tgaacaacct gagagccgag gacaccggca tctactactg caccttcggc      360

aacagcttcg cctattgggg ccagggcaca accgtgacag tttctagcgg aggcggtgga      420

tccggcggcg ggggatctgg tggcggaggt tctcaagctg tggtcacaca agagagcgcc      480

ctgacaacaa gccctggcga gacagtgacc ctgacctgta gatcttctac aggcgccgtg      540

accaccagca attacgccaa ctgggtgcaa gagaagcccg accacctgtt cacaggactg      600

atcggcggca ccaacaatag agcacctggc gtgccagcca gattcagcgg ctctctgatc      660

ggagataagg ccgcactgac aatcacaggc gcccagacag aggacgaggc catctatttc      720

tgcgccctgt ggtacagcaa ccactgggtt ttcggcggag gcaccaagct gacagtgctg      780

gaatctccta aggctcaggc cagcagcgtg ccaacagctc aacctcaggc tgaaggctct      840

ctggccaagg ctacaacagc ccctgccacc acaagaaaca caggcagagg cggcgaggaa      900

aagaagaaag agaaagagaa agaagaacaa gaggaacgcg agacaaagac ccctggccag      960

cctagagaac cccaggtgta cacactgcct ccaagcagag atgagctgac caagaaccag     1020

gtgtccctga catgcctggt caagggcttc tacccctccg atatcgccgt ggaatgggag     1080

agcaatggac agcccgagaa caactacaag accacacctc ctgtgctgga cagcgacggc     1140

tcattcttcc tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg     1200

ttcagctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgagc     1260

ctgtctcctg gaaaaggtgg cggcggatct caggtgcagc ttcagcaatc tggcgccgaa     1320

cttgctagac ctggcgcctc tgtgaagatg tcctgtaaag cctccggcta cacattcacc     1380

cggtacacca tgcactgggt caagcagagg cctggacagg gactcgagtg gatcggctac     1440

atcaacccca gcagaggcta caccaactac aatcagaagt tcaaggacaa ggccactctg     1500

accaccgaca agtctagcag caccgcctac atgcagctga gcagcctgac aagcgaggac     1560

agcgccgtgt actactgtgc ccggtactac gacgaccact actgcctgga ttactgggga     1620

cagggaacca cactgaccgt gtcatctggc ggtgggggaa gcggtggagg cggaagcggg     1680

ggtggtggat ctcaaattgt gctgacacag agccctgcca tcatgagcgc tagcccaggc     1740

gaaaaagtga caatgacctg ctccgccagc agctccgtgt cctacatgaa ctggtatcag     1800

cagaagtccg gcacaagccc caagagatgg atctacgaca cctccaagct ggcctctggg     1860

gtgcccgctc actttagagg atctggcagc ggcaccagct acagcctgac catctctgga     1920

atggaagccg aggatgccgc cacttactac tgccagcagt ggtccagcaa tcccttcaca     1980

tttggctccg ggaccaagct ggaaatcaac ggcagcgact acaaggacga cgacgacaag     2040

caccaccacc atcaccactg a                                               2061


<210>  46
<211>  114
<212>  DNA
<213>  Vaccinia virus

<400>  46
tttattctat acttaaaaaa tgaaaataaa tacaaaggtt cttgagggtt gtgttaaatt       60

gaaagcgaga aataatcata aattatttca ttatcgcgat atccgttaag tttg            114


<210>  47
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro 
            180                 


<210>  48
<211>  552
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nucleotide sequence encoding the human FLT3L gene

<400>  48
atgacagttc tggctccagc ttggtcccct acaacctacc tgctgctgct cctgctgctt       60

agctctggcc tgtctggcac acaggactgc agctttcagc acagccccat cagcagcgac      120

ttcgccgtga agatcagaga gctgagcgac tatctgctgc aggactaccc tgtgaccgtg      180

gccagcaatc tgcaggacga agaactgtgt ggtggcctgt ggcgactggt gctggctcag      240

agatggatgg aacggctgaa aacagtggcc ggcagcaaga tgcagggcct gctggaaaga      300

gtgaacaccg agatccactt cgtgaccaag tgcgccttcc agcctcctcc aagctgcctg      360

agattcgtgc agaccaacat cagcagactg ctgcaagaga caagcgagca gctggtggcc      420

ctgaagcctt ggatcaccag acagaacttc agccggtgcc tggaactgca gtgtcagccc      480

gatagcagca cactgcctcc accttggagc cccagacctc tggaagctac agctccaaca      540

gctccccagc ct                                                          552


<210>  49
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  MUC1 tandem repeat peptide

<400>  49

Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
1               5                   10                  15      


Ala Pro Gly Ser Thr Ala Pro Pro 
            20                  


