   б

<110>  Ǽݣ޹˾Ϻ޹˾

<120>  ɫ-صĿԭϵ׼Ӧ

<130>  0193-PA-007

<160>  70

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 CDR3

<400>  1

Ala Gly Glu Asn Met Arg Leu Val Thr 
1               5                   


<210>  2
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 CDR2

<400>  2

Asn Ile Pro Gly Asp Asp 
1               5       


<210>  3
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 CDR1

<400>  3

Gly Phe Thr Phe Ser Arg His 
1               5           


<210>  4
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 FR1

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  5
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 FR2

<400>  5

Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Asp Tyr Val 
1               5                   10                  15      


Gly Glu Ile 
            


<210>  6
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 FR3

<400>  6

Val Asp Tyr Asp Ile Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Thr Val Tyr Leu His Met Thr Asn Leu Lys Val Glu 
            20                  25                  30          


Asp Thr Ala Thr Tyr Trp Cys Ala Gln 
        35                  40      


<210>  7
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 FR4

<400>  7

Arg Arg Gln Gly Thr Gln Val Thr Val Ser Thr 
1               5                   10      


<210>  8
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huA3 FR1 huG1 FR1

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  9
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huA3 FR2

<400>  9

Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
1               5                   10                  15      


Gly Glu Ile 
            


<210>  10
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huA3 FR3

<400>  10

Val Asp Tyr Asp Ile Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  11
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huA3 FR4

<400>  11

Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  12
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Asp Tyr Val 
        35                  40                  45              


Gly Glu Ile Asn Ile Pro Gly Asp Asp Val Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Thr Asn Leu Lys Val Glu Asp Thr Ala Thr Tyr Trp Cys 
                85                  90                  95      


Ala Gln Ala Gly Glu Asn Met Arg Leu Val Thr Arg Arg Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Thr 
        115             


<210>  13
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huA3

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Gly Glu Ile Asn Ile Pro Gly Asp Asp Val Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Glu Asn Met Arg Leu Val Thr Arg Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  14
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 CDR3

<400>  14

Gln Gly Ala Asn Leu Arg Gln Gly Val 
1               5                   


<210>  15
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 CDR2

<400>  15

Asn Ile Pro Gly Thr Asp 
1               5       


<210>  16
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 CDR1

<400>  16

Gly Phe Thr Ile Ser Ser Thr 
1               5           


<210>  17
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 FR1

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ala Cys Glu Ala Ser 
            20                  25  


<210>  18
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 FR2

<400>  18

Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Asp Trp Val 
1               5                   10                  15      


Gly Asp Ile 
            


<210>  19
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 FR3

<400>  19

Thr Asp Tyr Asp Ile Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp 
1               5                   10                  15      


His Ala Lys Asn Thr Val Tyr Leu Gln Met Thr Ser Leu Arg Pro Glu 
            20                  25                  30          


Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
        35                  40      


<210>  20
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 FR4

<400>  20

Gln Ser Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huG1 FR2

<400>  21

Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Gly Asp Ile 
            


<210>  22
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huG1 FR3

<400>  22

Thr Asp Tyr Asp Ile Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp 
1               5                   10                  15      


His Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
        35                  40      


<210>  23
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huG1 FR4

<400>  23

Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  24
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1

<400>  24

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ala Cys Glu Ala Ser Gly Phe Thr Ile Ser Ser Thr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Asp Trp Val 
        35                  40                  45              


Gly Asp Ile Asn Ile Pro Gly Thr Asp Thr Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp His Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Gly Ala Asn Leu Arg Gln Gly Val Gln Ser Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  25
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huG1

<400>  25

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Thr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Asn Ile Pro Gly Thr Asp Thr Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp His Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Gly Ala Asn Leu Arg Gln Gly Val Gln Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  26
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 CDR3

<400>  26

Tyr Arg Asn Phe Gly Asn Phe Cys Val Met Gly Arg Tyr Glu Tyr Asp 
1               5                   10                  15      


Glu 
    


<210>  27
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 CDR2

<400>  27

Ser Arg Ser Gly Ala Ser 
1               5       


<210>  28
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 CDR1

<400>  28

Gly Ser Thr Leu Asp Ser Tyr 
1               5           


<210>  29
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 FR1

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser 
            20                  25  


<210>  30
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 FR2

<400>  30

Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
1               5                   10                  15      


Ser Cys Ala 
            


<210>  31
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 FR3

<400>  31

Thr Asn Tyr Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
            20                  25                  30          


Asp Thr Gly Val Tyr Tyr Cys Ala Ala 
        35                  40      


<210>  32
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 FR4

<400>  32

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  33
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huF6 FR1

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  34
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huF6 FR2

<400>  34

Thr Val Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ser Cys Ala 
            


<210>  35
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huF6 FR3

<400>  35

Thr Asn Tyr Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
        35                  40      


<210>  36
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huF6 FR4

<400>  36

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  37
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6

<400>  37

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Ser Thr Leu Asp Ser Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ala Ser Arg Ser Gly Ala Ser Thr Asn Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Arg Asn Phe Gly Asn Phe Cys Val Met Gly Arg Tyr Glu 
            100                 105                 110         


Tyr Asp Glu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  38
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huF6

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Asp Ser Tyr 
            20                  25                  30          


Thr Val Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Cys Ala Ser Arg Ser Gly Ala Ser Thr Asn Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Arg Asn Phe Gly Asn Phe Cys Val Met Gly Arg Tyr Glu 
            100                 105                 110         


Tyr Asp Glu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  39
<211>  232
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IgG1 Fc

<400>  39

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  40
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 CDR2 AbM

<400>  40

Glu Ile Asn Ile Pro Gly Asp Asp Val Asp 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 CDR1 AbM 

<400>  41

Gly Phe Thr Phe Ser Arg His Gly Met Thr 
1               5                   10  


<210>  42
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 CDR2 Kabat 

<400>  42

Glu Ile Asn Ile Pro Gly Asp Asp Val Asp Tyr Asp Ile Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 CDR1 Kabat

<400>  43

Arg His Gly Met Thr 
1               5   


<210>  44
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 CDR2 AbM

<400>  44

Asp Ile Asn Ile Pro Gly Thr Asp Thr Asp 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 CDR1 AbM 

<400>  45

Gly Phe Thr Ile Ser Ser Thr Gly Met Thr 
1               5                   10  


<210>  46
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 CDR2 Kabat 

<400>  46

Asp Ile Asn Ile Pro Gly Thr Asp Thr Asp Tyr Asp Ile Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1 CDR1 Kabat

<400>  47

Ser Thr Gly Met Thr 
1               5   


<210>  48
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 CDR2 AbM

<400>  48

Cys Ala Ser Arg Ser Gly Ala Ser Thr Asn 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 CDR1 AbM 

<400>  49

Gly Ser Thr Leu Asp Ser Tyr Thr Val Ala 
1               5                   10  


<210>  50
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 CDR2 Kabat 

<400>  50

Cys Ala Ser Arg Ser Gly Ala Ser Thr Asn Tyr Ala Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 CDR1 Kabat

<400>  51

Ser Tyr Thr Val Ala 
1               5   


<210>  52
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 CDR2; G1 CDR2

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AspThr

<400>  52

Asn Ile Pro Gly Xaa Asp 
1               5       


<210>  53
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 CDR1; G1 CDR1

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = PheIle

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = HisThr

<400>  53

Gly Phe Thr Xaa Ser Xaa Xaa 
1               5           


<210>  54
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 FR1; huA3 FR1; huG1 FR1; G1 FR1; F6 FR1; huF6 FR1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaGluVal

<400>  54

Xaa Val Gln Leu Val Glu Ser Gly Gly Xaa Leu Xaa Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Xaa Cys Xaa Ala Ser 
            20                  25  


<210>  55
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 FR2; huA3 FR2; G1 FR2; huG1 FR2

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = TrpTyr

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = AspGlu

<400>  55

Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Xaa Leu Xaa Xaa Val 
1               5                   10                  15      


Gly Xaa Ile 
            


<210>  56
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6 FR2; huF6 FR2

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = PheVal

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = GlyTrp

<400>  56

Thr Val Ala Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val 
1               5                   10                  15      


Ser Cys Ala 
            


<210>  57
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 FR3; huA3 FR3; G1 FR3; huG1 FR3

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = HisAsn

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = HisGln

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = AsnThr

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AlaProVal

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa = IleThrVal

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa = TrpTyr

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa = LysGlnArg

<400>  57

Xaa Asp Tyr Asp Ile Ser Val Lys Gly Arg Phe Thr Ile Ser Xaa Asp 
1               5                   10                  15      


Xaa Ala Lys Asn Thr Xaa Tyr Leu Xaa Met Xaa Xaa Leu Xaa Xaa Glu 
            20                  25                  30          


Asp Thr Ala Xaa Tyr Xaa Cys Ala Xaa 
        35                  40      


<210>  58
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huF6 FR3; F6 FR3

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = AlaGly

<400>  58

Thr Asn Tyr Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Xaa Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Xaa Xaa Glu 
            20                  25                  30          


Asp Thr Xaa Val Tyr Tyr Cys Ala Ala 
        35                  40      


<210>  59
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3 FR4; huA3 FR4; G1 FR4; huG1 FR4; F6 FR4; huF6 FR4

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GlnArgTrp

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = GlyArgSer

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = ProGln

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuGln

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = SerThr

<400>  59

Xaa Xaa Xaa Gly Thr Xaa Val Thr Val Ser Xaa 
1               5                   10      


<210>  60
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3; huA3; G1; huG1

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaGluVal

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = PheIle

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = HisThr

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa = TrpTyr

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = AspThr

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = HisAsn

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = HisGln

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = AsnThr

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaProVal

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = IleThrVal

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa = TrpTyr

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa = LysGlnArg

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa = AlaGln

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa = AlaGlu

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa = LeuGln

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa = GlyVal

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa = GlnArg

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa = GlyArgSer

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa = ProGln

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa = LeuGln

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa = SerThr

<400>  60

Gln Val Gln Leu Val Glu Ser Gly Gly Xaa Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Xaa Cys Xaa Ala Ser Gly Phe Thr Xaa Ser Xaa Xaa 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Xaa Leu Xaa Xaa Val 
        35                  40                  45              


Gly Xaa Ile Asn Ile Pro Gly Xaa Asp Xaa Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Xaa Asp Xaa Ala Lys Asn Thr Xaa Tyr 
65                  70                  75                  80  


Leu Xaa Met Xaa Xaa Leu Xaa Xaa Glu Asp Thr Ala Xaa Tyr Xaa Cys 
                85                  90                  95      


Ala Xaa Xaa Gly Xaa Asn Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Gly Thr 
            100                 105                 110         


Xaa Val Thr Val Ser Xaa 
        115             


<210>  61
<211>  126
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6; huF6

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaGlu

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa = PheVal

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa = GlyTrp

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa = LeuGln

<400>  61

Xaa Val Gln Leu Val Glu Ser Gly Gly Gly Leu Xaa Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Xaa Ala Ser Gly Ser Thr Leu Asp Ser Tyr 
            20                  25                  30          


Thr Val Ala Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val 
        35                  40                  45              


Ser Cys Ala Ser Arg Ser Gly Ala Ser Thr Asn Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr Xaa Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Arg Asn Phe Gly Asn Phe Cys Val Met Gly Arg Tyr Glu 
            100                 105                 110         


Tyr Asp Glu Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120                 125     


<210>  62
<211>  350
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  A3-Fc

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Asp Tyr Val 
        35                  40                  45              


Gly Glu Ile Asn Ile Pro Gly Asp Asp Val Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Thr Asn Leu Lys Val Glu Asp Thr Ala Thr Tyr Trp Cys 
                85                  90                  95      


Ala Gln Ala Gly Glu Asn Met Arg Leu Val Thr Arg Arg Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 


<210>  63
<211>  350
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G1-Fc

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ala Cys Glu Ala Ser Gly Phe Thr Ile Ser Ser Thr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Asp Trp Val 
        35                  40                  45              


Gly Asp Ile Asn Ile Pro Gly Thr Asp Thr Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp His Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Gly Ala Asn Leu Arg Gln Gly Val Gln Ser Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 


<210>  64
<211>  358
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  F6-Fc

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Ser Thr Leu Asp Ser Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ala Ser Arg Ser Gly Ala Ser Thr Asn Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Arg Asn Phe Gly Asn Phe Cys Val Met Gly Arg Tyr Glu 
            100                 105                 110         


Tyr Asp Glu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro 
        115                 120                 125             


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            260                 265                 270         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         


Ser Leu Ser Pro Gly Lys 
        355             


<210>  65
<211>  483
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huA3-huA3-Fc

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Gly Glu Ile Asn Ile Pro Gly Asp Asp Val Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Glu Asn Met Arg Leu Val Thr Arg Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Arg His Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Tyr Val Gly Glu Ile Asn Ile Pro Gly Asp Asp Val Asp 
            180                 185                 190         


Tyr Asp Ile Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Ala Gly Glu Asn Met Arg Leu Val Thr 
225                 230                 235                 240 


Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
        275                 280                 285             


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  66
<211>  483
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huG1-huG1-Fc

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Thr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Asn Ile Pro Gly Thr Asp Thr Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp His Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Gly Ala Asn Leu Arg Gln Gly Val Gln Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Ile Ser Ser Thr Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Gly Asp Ile Asn Ile Pro Gly Thr Asp Thr Asp 
            180                 185                 190         


Tyr Asp Ile Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp His Ala 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Lys Gln Gly Ala Asn Leu Arg Gln Gly Val 
225                 230                 235                 240 


Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
        275                 280                 285             


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  67
<211>  483
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huA3-huG1-Fc

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Gly Glu Ile Asn Ile Pro Gly Asp Asp Val Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Glu Asn Met Arg Leu Val Thr Arg Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Ile Ser Ser Thr Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Gly Asp Ile Asn Ile Pro Gly Thr Asp Thr Asp 
            180                 185                 190         


Tyr Asp Ile Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp His Ala 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Lys Gln Gly Ala Asn Leu Arg Gln Gly Val 
225                 230                 235                 240 


Gln Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
        275                 280                 285             


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys 
            

<210>  68
<211>  350
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HuA3-Fc

<400>  68

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Gly Glu Ile Asn Ile Pro Gly Asp Asp Val Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Glu Asn Met Arg Leu Val Thr Arg Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 


<210>  69
<211>  350
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HuG1-Fc

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Thr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Asn Ile Pro Gly Thr Asp Thr Asp Tyr Asp Ile Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp His Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Gly Ala Asn Leu Arg Gln Gly Val Gln Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 


<210>  70
<211>  358
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HuF6-Fc

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Asp Ser Tyr 
            20                  25                  30          


Thr Val Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Cys Ala Ser Arg Ser Gly Ala Ser Thr Asn Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Arg Asn Phe Gly Asn Phe Cys Val Met Gly Arg Tyr Glu 
            100                 105                 110         


Tyr Asp Glu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
        115                 120                 125             


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            260                 265                 270         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         


Ser Leu Ser Pro Gly Lys 
        355             
