б

<110>  ݶڰе＼޹˾
 
<120>  ҩƷ;

<130>  0027-PA-039

<160>   64

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2VH

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Val Leu Ile Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Leu Leu Thr Val Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2HCDR1

<400>  2

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  3
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2HCDR2

<400>  3

Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  


<210>  4
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2HCDR3

<400>  4

Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val 
1               5                   10  


<210>  5
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2HFR1

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  6
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2HFR2VHV2еH-FR2VHV3еH-FR2

<400>  6

Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Val Leu Ile 
1               5                   10                  15      


<210>  7
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2HFR3

<400>  7

Leu Leu Thr Val Ser Lys Asp Thr Ser Asn Asn Gln Val Phe Leu Lys 
1               5                   10                  15      


Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  8
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2HFR4VHV3еH-FR4

<400>  8

Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  9
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2VL

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  10
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2LCDR1

<400>  10

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  11
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2LCDR2

<400>  11

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2LCDR3

<400>  12

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  13
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2LFR1

<400>  13

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  14
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2LFR2VLV3еL-FR2VLV4еL-FR2

<400>  14

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  15
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2LFR3

<400>  15

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  16
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2LFR4VLV3еL-FR4VLV4еL-FR4

<400>  16

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  17
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHV1

<400>  17

Gln Val Thr Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Val Leu Ile Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Leu Leu Thr Val Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Ile Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHV2

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Val Leu Ile Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Leu Leu Thr Val Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Ile Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHV3

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Val Leu Ile Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Leu Leu Thr Val Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Ile Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLV2

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLV3

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  22
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLV4

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHͨʽ3E2VHVHV1~VHV3)


<220>
<221>  X
<222>  (3)..(3)
<223>  XΪTQ

<220>
<221>  X
<222>  (10)..(10)
<223>  XΪGT

<220>
<221>  X
<222>  (11)..(11)
<223>  XΪIL

<220>
<221>  X
<222>  (12)..(12)
<223>  XΪLV

<220>
<221>  X
<222>  (13)..(13)
<223>  XΪQK

<220>
<221>  X
<222>  (15)..(15)
<223>  XΪST

<220>
<221>  X
<222>  (19)..(19)
<223>  XΪST

<220>
<221>  X
<222>  (23)..(23)
<223>  XΪST

<220>
<221>  X
<222>  (43)..(43)
<223>  XΪPS

<220>
<221>  X
<222>  (72)..(72)
<223>  XΪST

<220>
<221>  X
<222>  (77)..(77)
<223>  XΪNK

<220>
<221>  X
<222>  (81)..(81)
<223>  XΪFV

<220>
<221>  X
<222>  (83)..(83)
<223>  XΪKT

<220>
<221>  X
<222>  (85)..(85)
<223>  XΪAT

<220>
<221>  X
<222>  (86)..(86)
<223>  XΪSN

<220>
<221>  X
<222>  (87)..(87)
<223>  XΪVM

<220>
<221>  X
<222>  (89)..(89)
<223>  XΪTP

<220>
<221>  X
<222>  (90)..(90)
<223>  XΪAV

<220>
<221>  X
<222>  (112)..(112)
<223>  XQT

<220>
<221>  X
<222>  (115)..(115)
<223>  XMT

<400>  23

Gln Val Xaa Leu Gln Glu Ser Gly Pro Xaa Xaa Xaa Xaa Pro Xaa Gln 
1               5                   10                  15      


Thr Leu Xaa Leu Thr Cys Xaa Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Xaa Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Val Leu Ile Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Leu Leu Thr Val Xaa Lys Asp Thr Ser Xaa Asn Gln Val 
65                  70                  75                  80  


Xaa Leu Xaa Ile Xaa Xaa Xaa Asp Xaa Xaa Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val Trp Gly Xaa 
            100                 105                 110         


Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLͨʽ3E2VLVLV2~VLV4)


<220>
<221>  X
<222>  (14)..(14)
<223>  XST

<220>
<221>  X
<222>  (17)..(17)
<223>  XQD

<220>
<221>  X
<222>  (18)..(18)
<223>  XPQ

<220>
<221>  X
<222>  (44)..(44)
<223>  XRK

<220>
<221>  X
<222>  (88)..(88)
<223>  XΪLV

<220>
<221>  X
<222>  (109)..(109)
<223>  XVL

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Xaa Leu Gly 
1               5                   10                  15      


Xaa Xaa Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Xaa Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Xaa Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
            100                 105                 110         


<210>  25
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHV1еH-FR1

<400>  25

Gln Val Thr Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  26
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHV1еH-FR2

<400>  26

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Val Leu Ile 
1               5                   10                  15      


<210>  27
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHV1еH-FR3VHV2еH-FR3VHV3еH-FR3

<400>  27

Leu Leu Thr Val Thr Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr 
1               5                   10                  15      


Ile Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  28
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHV1еH-FR4VHV2еH-FR4

<400>  28

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  29
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHV2еH-FR1VHV3еH-FR1

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  30
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLV2еL-FR1VLV3еL-FR1

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  31
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLV2еL-FR2

<400>  31

Trp Tyr Leu Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  32
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLV2еL-FR3VLV3еL-FR3VLV4еL-FR3

<400>  32

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  33
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLV2еL-FR4

<400>  33

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  34
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLV4еL-FR1

<400>  34

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  35
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽ3E2H-FR1VHV1~VHV3еH-FR1)


<220>
<221>  X
<222>  (3)..(3)
<223>  XΪTQ

<220>
<221>  X
<222>  (10)..(10)
<223>  XΪGT

<220>
<221>  X
<222>  (11)..(11)
<223>  XΪIL

<220>
<221>  X
<222>  (12)..(12)
<223>  XΪLV

<220>
<221>  X
<222>  (13)..(13)
<223>  XΪQK

<220>
<221>  X
<222>  (15)..(15)
<223>  XΪST

<220>
<221>  X
<222>  (19)..(19)
<223>  XΪST

<220>
<221>  X
<222>  (23)..(23)
<223>  XΪST

<400>  35

Gln Val Xaa Leu Gln Glu Ser Gly Pro Xaa Xaa Xaa Xaa Pro Xaa Gln 
1               5                   10                  15      


Thr Leu Xaa Leu Thr Cys Xaa Phe Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  36
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2ͨʽ3E2H-FR2VHV1~VHV3еH-FR2)


<220>
<221>  X
<222>  (6)..(6)
<223>  XΪPS

<400>  36

Trp Ile Arg Gln Pro Xaa Gly Lys Gly Leu Glu Trp Leu Val Leu Ile 
1               5                   10                  15      


<210>  37
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3ͨʽ3E2H-FR3VHV1~VHV3еH-FR3)


<220>
<221>  X
<222>  (5)..(5)
<223>  XΪST

<220>
<221>  X
<222>  (10)..(10)
<223>  XΪNK

<220>
<221>  X
<222>  (14)..(14)
<223>  XΪFV

<220>
<221>  X
<222>  (16)..(16)
<223>  XΪKT

<220>
<221>  X
<222>  (18)..(18)
<223>  XΪAT

<220>
<221>  X
<222>  (19)..(19)
<223>  XΪSN

<220>
<221>  X
<222>  (20)..(20)
<223>  XΪVM

<220>
<221>  X
<222>  (22)..(22)
<223>  XΪTP

<220>
<221>  X
<222>  (23)..(23)
<223>  XΪAV

<400>  37

Leu Leu Thr Val Xaa Lys Asp Thr Ser Xaa Asn Gln Val Xaa Leu Xaa 
1               5                   10                  15      


Ile Xaa Xaa Xaa Asp Xaa Xaa Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  38
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4ͨʽ3E2H-FR4VHV1~VHV3еH-FR4)


<220>
<221>  X
<222>  (3)..(3)
<223>  XQT

<220>
<221>  X
<222>  (6)..(6)
<223>  XMT

<400>  38

Trp Gly Xaa Gly Thr Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  39
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR1ͨʽ3E2L-FR1VLV2~VLV4еL-FR1)


<220>
<221>  X
<222>  (14)..(14)
<223>  XST

<220>
<221>  X
<222>  (17)..(17)
<223>  XQD

<220>
<221>  X
<222>  (18)..(18)
<223>  XPQ

<400>  39

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Xaa Leu Gly 
1               5                   10                  15      


Xaa Xaa Ala Ser Ile Ser Cys 
            20              


<210>  40
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR2ͨʽ3E2L-FR2VLV2~VLV4еL-FR2)


<220>
<221>  X
<222>  (5)..(5)
<223>  XRK

<400>  40

Trp Tyr Leu Gln Xaa Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  41
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR3ͨʽ3E2L-FR3VLV2~VLV4еL-FR3)


<220>
<221>  X
<222>  (27)..(27)
<223>  XΪLV

<400>  41

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Xaa Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  42
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR4ͨʽ3E2L-FR4VLV2~VLV4еL-FR4)


<220>
<221>  X
<222>  (7)..(7)
<223>  XVL

<400>  42

Phe Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
1               5                   10  


<210>  43
<211>  450
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2 1-2/1-3/1-4 HC

<400>  43

Gln Val Thr Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Val Leu Ile Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Leu Leu Thr Val Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Ile Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  44
<211>  450
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2 2-2/2-3/2-4 HC

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Val Leu Ile Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Leu Leu Thr Val Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Ile Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  45
<211>  450
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2 3-2/3-3/3-4 HC

<400>  45

Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Val Leu Ile Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Leu Leu Thr Val Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Ile Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  46
<211>  219
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2 1-2/2-2/3-2 LC

<400>  46

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  47
<211>  219
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2 1-3/2-3/3-3 LC

<400>  47

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  48
<211>  219
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3E2 1-4/2-4/3-4 LC

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  49
<211>  450
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C3E2

<400>  49

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Val Leu Ile Leu Trp Asn Asp Ile Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Leu Leu Thr Val Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Asp Gly Tyr Tyr Gly Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  50
<211>  219
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  C3E2

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  51
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  52
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  53
<211>  360
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  3E2VHĺ

<400>  53
caggtccaac tgcaggagtc aggccctggg atactgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttttggta tgggtgtagg ctggattcgt      120

cagccttcag ggaagggtct ggaatggctg gtactcattt tatggaatga tattaagtac      180

tataacccag ccctgaagag cctgctcaca gtctccaagg atacctccaa caaccaggtt      240

ttcctcaaga tcgccagtgt ggacaccgca gatactgcca catactactg tgctcgcgta      300

gatggttact acgggtactt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca      360


<210>  54
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  3E2VLĺ

<400>  54
gatatcgtga tgacccaatc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaccattgta catagtaatg gaaacaccta tttagaatgg      120

tatctgcaga aaccaggcca gtctccaaag ctcctaatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  55
<211>  360
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VHV1ĺ

<400>  55
caagttactt tacaagaaag cggccctact ttagtgaagc ccacccagac tttaacttta       60

acttgtacct tcagcggctt ctctttaagc accttcggca tgggcgtggg ctggatcaga      120

cagcctcccg gtaagggttt agagtggctg gtgctgattt tatggaacga catcaagtac      180

tacaaccccg ctttaaagtc tttactgacc gtgaccaagg acaccagcaa gaaccaagtt      240

gtgctgacca tcaccaacat ggaccccgtg gacaccgcca catactactg cgctcgtgtg      300

gacggctact acggctactt cgacgtgtgg ggccaaggca ctatggtgac agtgagcagc      360


<210>  56
<211>  360
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VHV2ĺ

<400>  56
caagttcagc tgcaagaaag cggccccaca ctggtgaagc ccacccagac tttaacttta       60

acttgtacct tcagcggctt ctctttaagc accttcggca tgggcgtggg ctggattcgt      120

cagcctagcg gcaagggttt agagtggctg gtgctgattt tatggaacga catcaagtac      180

tacaaccccg ctttaaagtc tttactgacc gtgaccaagg acaccagcaa gaaccaagtt      240

gtgctgacca tcaccaacat ggaccccgtg gacaccgcca cctactattg cgctcgtgtg      300

gacggctact acggctactt cgacgtgtgg ggccaaggta caatggtgac cgtgagcagc      360


<210>  57
<211>  360
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VHV3ĺ

<400>  57
caagttcagc tgcaagaaag cggccccaca ctggtgaagc ccacccagac tttaacttta       60

acttgtacct tcagcggctt ctctttaagc accttcggca tgggcgtggg ctggattcgt      120

cagcctagcg gcaagggttt agagtggctg gtgctgattt tatggaacga catcaagtac      180

tacaaccccg ctttaaagtc tttactgacc gtgaccaagg acaccagcaa gaaccaagtt      240

gtgctgacca tcaccaacat ggaccccgtg gacaccgcca cctactattg cgctcgtgtg      300

gacggctact acggctactt cgacgtgtgg ggcaccggta caaccgtgac cgtgagcagc      360


<210>  58
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VLV2ĺ

<400>  58
gacatcgtga tgacccagag ccctctgtct ttacccgtta ctttaggaca gcccgctagc       60

atcagctgtc gtagcagcca gaccatcgtg cacagcaacg gcaacaccta tttagagtgg      120

tacttacaga gacccggcca gagccccaag ctgctcatct acaaggtgag caatcgtttc      180

tccggcgtgc ccgatagatt tagcggcagc ggtagcggca ccgactttac tttaaagatc      240

agcagagtgg aggccgagga cgtgggcgtg tactactgct tccaaggtag ccatgtgcct      300

tggaccttcg gcggcggcac caaggtggag atcaag                                336


<210>  59
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VLV3ĺ

<400>  59
gacatcgtga tgacccagag ccctttatct ttacccgtta cactgggaca gcccgccagc       60

atcagctgtc gtagcagcca gaccatcgtg cacagcaacg gcaacaccta tttagagtgg      120

tatttacaga agcccggcca gagccccaag ctgctgatct acaaggtgag caatcgtttc      180

agcggcgtgc ccgacagatt cagcggaagc ggcagcggca ccgacttcac tttaaagatc      240

agcagagtgg aggccgagga cgtgggcgtg tactactgct tccaaggtag ccatgtgcct      300

tggaccttcg gaggcggcac caagctggag atcaag                                336


<210>  60
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VLV4ĺ

<400>  60
gacatcgtga tgacccagag ccctttatct ttacccgtta cactgggaga ccaggccagc       60

atcagctgtc gtagcagcca gaccatcgtg cacagcaacg gcaacaccta tttagagtgg      120

tatttacaga agcccggcca gagccccaag ctgctgatct acaaggtgag caatcgtttc      180

agcggcgtgc ccgacagatt cagcggaagc ggcagcggca ccgacttcac tttaaagatc      240

agcagagtgg aggccgagga cgtgggcgtg tactactgct tccaaggtag ccatgtgcct      300

tggaccttcg gaggcggcac caagctggag atcaag                                336


<210>  61
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1VL1

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  62
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1VL2

<400>  62

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  63
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1VH1

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  64
<211>  113
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1VH2

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser   


