                         SEQUENCE LISTING

<110>  Shenzhen FrontierGate Biotechnology Co., LTD
       Guangdong SanSci Biotechnology Co.LTD
 
<120>  DENDRITIC CELL ACTIVATING CHIMERIC ANTIGEN RECEPTORS AND USES 
       THEREOF

<130>  082971-8001WO01

<150>  202110022268.5
<151>  2021-01-08

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Arg Trp Pro Pro Ser Ala Ala Cys Ser Gly Lys Glu Ser Val Val Ala 
1               5                   10                  15      


Ile Arg Thr Asn Ser Gln Ser Asp Phe His Leu Gln Thr Tyr Gly Asp 
            20                  25                  30          


Glu Asp Leu Asn Glu Leu Asp Pro His Tyr Glu Met 
        35                  40                  


<210>  2
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys 
1               5                   10                  15      


Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr 
            20                  25                  30          


Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40          


<210>  3
<211>  86
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Arg Trp Pro Pro Ser Ala Ala Cys Ser Gly Lys Glu Ser Val Val Ala 
1               5                   10                  15      


Ile Arg Thr Asn Ser Gln Ser Asp Phe His Leu Gln Thr Tyr Gly Asp 
            20                  25                  30          


Glu Asp Leu Asn Glu Leu Asp Pro His Tyr Glu Met Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  4
<211>  258
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  4
cgctggcctc cttctgcagc ttgttcggga aaagagtcag ttgttgctat aaggaccaat       60

agccaatctg acttccactt acaaacttat ggagatgaag atttgaatga attagatcct      120

cattatgaaa tgcgactgaa gatccaagtg cgaaaggcag ctataaccag ctatgagaaa      180

tcagatggtg tttacacggg cctgagcacc aggaaccagg agacttacga gactctgaag      240

catgagaaac caccacag                                                    258


<210>  5
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  6
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  7
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  8
<211>  383
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Met His Val Ala Gln Pro 
            20                  25                  30          


Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu 
        35                  40                  45              


Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg 
    50                  55                  60                  


Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met 
65                  70                  75                  80  


Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser 
                85                  90                  95      


Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp 
            100                 105                 110         


Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr 
        115                 120                 125             


Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu 
    130                 135                 140                 


Pro Cys Pro Asp Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His 
145                 150                 155                 160 


Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
                165                 170                 175     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            180                 185                 190         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        195                 200                 205             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    210                 215                 220                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
225                 230                 235                 240 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                245                 250                 255     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            260                 265                 270         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        275                 280                 285             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    290                 295                 300                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
305                 310                 315                 320 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                325                 330                 335     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            340                 345                 350         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        355                 360                 365             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380             


<210>  9
<211>  290
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  10
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser 
1               5                   10  


<210>  11
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Thr Ile Ser Ser Arg Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Glu Ala Ile Phe Thr His 
1               5       


<210>  13
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Lys Ala Ser Gln Asp Ile Asn Asn Tyr His Ser 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Leu Lys Tyr Asn Val Phe Pro Tyr Thr 
1               5                   


<210>  16
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Ser Ser Arg Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Phe Thr His Trp Gly Arg Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  17
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


His Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Lys Tyr Asn Val Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  18
<211>  237
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Ser Ser Arg Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Ile Phe Thr His Trp Gly Arg Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn 
145                 150                 155                 160 


Asn Tyr His Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
                165                 170                 175     


Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Asp Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile 
        195                 200                 205             


Glu Ser Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Lys Tyr Asn Val Phe 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235         


<210>  19
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  19
cagagcctcg cctttgccga tc                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  20
catccatggt gagctggcgg cg                                                22


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  21
ggggcaagat ggtaatgaag                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  22
ccaggatact gagggcatgt                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  23
gcacttcctc cagaggtttg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  24
tcaccaggat gctcacattt                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  25
gctgcacttt ggagtgatcg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  26
tcactcgggg ttcgagaaga                                                   20


<210>  27
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  27
cccagcatct gcaaagctc                                                    19


<210>  28
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  28
gtcaatgtac agctgccgca                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  29
ggcttttcag ctctgcatcg                                                   20


<210>  30
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  30
cgctacatct gaatgacctg c                                                 21


<210>  31
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  31
tctgagcaga ccctggtaca                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  32
gcaaggtaat gggggtcaca                                                   20


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  33
ccaaccacag cttcatgtgt c                                                 21


<210>  34
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  34
aaagcagtag gtcaggcagc                                                   20


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  35
acgacgtttc catcagcttg t                                                 21


<210>  36
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  36
tccaaggaat gtggtctggg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  37
tacccaccgc catactacct                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  38
ctcagggtct tcgtggctca                                                   20


<210>  39
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  39
ccattccgct aggaaagaca a                                                 21


<210>  40
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  40
cctgtgttct ctgtggacta tg                                                22


<210>  41
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  41
ctctagcaga cagtgggatc ta                                                22


<210>  42
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  42
gaccttggct ggtttgatga                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  43
tgacgaattg tggatcggct                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  44
ctggaccttg gcttcgtgat                                                   20


<210>  45
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  45
gtagtctgct caagatacac aga                                               23


<210>  46
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  46
acaatctccc atgtgctgct                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  47
tgccgttcac aagctcaagt                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  48
actccaggtg tcagggtact                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  49
ttgctccagc tcctctatct                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  50
gcctttggct ttcacctttg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  51
gtggtgccga ctacaagcga                                                   20


<210>  52
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  52
tttggaggat gtgccagagg t                                                 21


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  53
actcacctct tcagaacgaa ttg                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  54
ccatctttgg aaggttcagg ttg                                               23


<210>  55
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  55
ccaactgctt ccccctctg                                                    19


<210>  56
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  56
tctgttacgg tcaactcggt g                                                 21


<210>  57
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  57

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  58
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  58

Tyr Gly Asp Glu Asp Leu 
1               5       


<210>  59
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  59

Tyr Thr Gly Leu 
1               


<210>  60
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  60

Tyr Glu Thr Leu 
1               


